Gene Symbol: SNX6
Description: sorting nexin 6
Alias: MSTP010, TFAF2, sorting nexin-6, TRAF4-associated factor 2, tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
Species: human
Products:     SNX6

Top Publications

  1. Teasdale R, Loci D, Houghton F, Karlsson L, Gleeson P. A large family of endosome-localized proteins related to sorting nexin 1. Biochem J. 2001;358:7-16 pubmed
    ..The members of one subgroup, which includes human SNX1, SNX2, SNX4, SNX5 and SNX6 and the yeast Vps5p and YJL036W, all contain coiled-coil regions within their large C-terminal domains and are ..
  2. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..We now describe a novel member of this family, SNX6, which interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases...
  3. Wassmer T, Attar N, Bujny M, Oakley J, Traer C, Cullen P. A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J Cell Sci. 2007;120:45-54 pubmed
    ..Using this screen, we identified two proteins, SNX5 and SNX6, that, when suppressed, induced a phenotype similar to that observed upon suppression of known retromer components...
  4. Cavet M, Pang J, Yin G, Berk B. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J. 2008;22:3607-16 pubmed publisher
    ..We demonstrate that GIT1 interacts with sorting nexin 6 (SNX6), a member of the SNX family that increases EGFR trafficking between endosomes and lysosomes, thereby ..
  5. Niu Y, Zhang C, Sun Z, Hong Z, Li K, Sun D, et al. PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. Nat Cell Biol. 2013;15:417-29 pubmed publisher
    ..the protein-protein interaction between the p150(Glued) subunit of dynein-dynactin and the retromer component SNX6. We show that PtdIns(4)P specifically facilitates dissociation of retromer-mediated membranous cargoes from the ..
  6. Okada H, Zhang W, Peterhoff C, Hwang J, Nixon R, Ryu S, et al. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 2010;24:2783-94 pubmed publisher
    ..approach based on in-cell chemical cross-linking and tandem affinity purification (TAP), we herein identify sorting nexin 6 (SNX6) as a BACE1-associated protein...
  7. Itai N, Shimazu T, Kimura T, Ibe I, Yamashita R, Kaburagi Y, et al. The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis. PLoS ONE. 2018;13:e0207205 pubmed publisher
    ..SNX5 and SNX6 support each other's functions and are involved with CI-M6PR retrograde trafficking...
  8. Kim K, Kim M, Adamopoulos I, Tagkopoulos I. Compendium of synovial signatures identifies pathologic characteristics for predicting treatment response in rheumatoid arthritis patients. Clin Immunol. 2019;202:1-10 pubmed publisher
    ..Similarly, the expression of the HMMR, PRPF4B, EVI2A, RAB27A, MALT1, SNX6, and IFIH1 genes contributed in predicting the patient outcome...
  9. Pang S, Li Y, Chen W, Li Y, Yang M, Zhao L, et al. Pb exposure reduces the expression of SNX6 and Homer1 in offspring rats and PC12 cells. Toxicology. 2019;416:23-29 pubmed publisher
    ..Studies have shown that SNX6 and Homer1 can regulate the growth of dendritic spines...

More Information


  1. Hu P, Liang Y, Hu Q, Wang H, Cai Z, He J, et al. SNX6 predicts poor prognosis and contributes to the metastasis of pancreatic cancer cells via activating epithelial-mesenchymal transition. Acta Biochim Biophys Sin (Shanghai). 2018;50:1075-1084 pubmed publisher
    ..In the present study, by using the Cancer Genome Atlas (TCGA) dataset analysis, we demonstrated that sorting nexin 6 (SNX6) serves as a biomarker for predicting prognosis of pancreatic cancer...
  2. Yong X, Hu W, Zhou X, Wang J, Burstein E, Jia D. Expression and purification of the SNX1/SNX6 complex. Protein Expr Purif. 2018;151:93-98 pubmed publisher
    ..Here a detailed expression and purification protocol of the SNX1/SNX6 complex, from both worm and human, is described...
  3. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6. We have found that the unrelated sorting nexin, SNX3, has an evolutionarily conserved function in Wls recycling ..
  4. David D, Pagliuso A, Radoshevich L, Nahori M, Cossart P. Lmo1656 is a secreted virulence factor of Listeria monocytogenes that interacts with the sorting nexin 6-BAR complex. J Biol Chem. 2018;293:9265-9276 pubmed publisher
    ..We identified sorting nexin 6 (SNX6), an endosomal sorting component and BAR domain-containing protein, as a host cell interactor of ..
  5. Chang Y, Huang H, Yeh K, Chang J. Identification of novel mutations in endometrial cancer patients by whole-exome sequencing. Int J Oncol. 2017;50:1778-1784 pubmed publisher
  6. Lin T, Hsieh M, Lai C, Cheng J, Chau Y, Ruan T, et al. Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade. J Neurosci. 2015;35:16545-60 pubmed publisher
    ..a novel Fbxo3 inhibitor) prevented SNL-induced Fbxl2 ubiquitination and subsequent TFAF2 de-ubiquitination to ameliorate behavioral allodynia via antagonizing TRAF2/TNIK/GluR1 signaling...
  7. Li Q, Li X, Wang L, Zhang Y, Chen L. miR-98-5p Acts as a Target for Alzheimer's Disease by Regulating A? Production Through Modulating SNX6 Expression. J Mol Neurosci. 2016;60:413-420 pubmed
    ..In the present study, we confirmed that miR-98-5p negatively regulated sorting nexin 6 (SNX6) expression by targeting the 3'-UTR of SNX6 mRNA...
  8. Paul B, Kim H, Kerr M, Huston W, Teasdale R, Collins B. Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis. elife. 2017;6: pubmed publisher
    ..The binding site is unique to SNX5 and related family members SNX6 and SNX32...
  9. Bareja A, Hodgkinson C, Soderblom E, Waitt G, Dzau V. The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway. J Biol Chem. 2018;293:6449-6459 pubmed publisher
    ..One of the novel interactors was sorting nexin 6 (SNX6), a protein that forms part of the retromer complex, which is involved in intracellular protein sorting...
  10. Marquer C, Tian H, Yi J, Bastien J, Dall Armi C, Yang Klingler Y, et al. Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. Nat Commun. 2016;7:11919 pubmed publisher
    ..of retromer, which controls the retrograde transport of CI-M6PR via sorting nexins, including the PI4P effector SNX6. Finally, reducing PI4P levels in KO MEFs through independent mechanisms rescues aberrant retromer tubulation and ..
  11. Niu Y, Dai Z, Liu W, Zhang C, Yang Y, Guo Z, et al. Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. elife. 2017;6: pubmed publisher
    b>SNX6 is a ubiquitously expressed PX-BAR protein that plays important roles in retromer-mediated retrograde vesicular transport from endosomes...
  12. Wurthner J, Frank D, Felici A, Green H, Cao Z, Schneider M, et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem. 2001;276:19495-502 pubmed
  13. Sander L, Frank S, Bolat S, Blank U, Galli T, Bigalke H, et al. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol. 2008;38:855-63 pubmed publisher
    ..In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation...
  14. Kvainickas A, Jimenez Orgaz A, Nägele H, Hu Z, Dengjel J, Steinberg F. Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. J Cell Biol. 2017;216:3677-3693 pubmed publisher
    ..In this study, we demonstrate that heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the TGN ..
  15. Maruzs T, Lőrincz P, Szatmári Z, Széplaki S, Sándor Z, Lakatos Z, et al. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Traffic. 2015;16:1088-107 pubmed publisher
    ..Finally, we find that Snx3 and Snx6 are also required for proper autolysosomal degradation in Drosophila larval fat body cells.
  16. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
    ..whose membrane-bound subcomplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6. We establish that retromer requires a dynamic spatial organization of the endosomal network, which is regulated ..
  17. Saeed M. Novel linkage disequilibrium clustering algorithm identifies new lupus genes on meta-analysis of GWAS datasets. Immunogenetics. 2017;69:295-302 pubmed publisher
    ..New SLE genes that OASIS identified and were further verified include TNFAIP6, DNAJB3, TTF1, GRIN2B, MON2, LATS2, SNX6, RBFOX1, NCOA3, and CHAF1B...
  18. Trousdale C, Kim K. Retromer: Structure, function, and roles in mammalian disease. Eur J Cell Biol. 2015;94:513-21 pubmed publisher
    ..Despite the current understanding of the retromer complex, there are still many questions to be answered in regards to its overall role in cell homeostasis. ..
  19. Simonetti B, Danson C, Heesom K, Cullen P. Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. J Cell Biol. 2017;216:3695-3712 pubmed publisher
    ..The retromer-linked SNX-BAR proteins comprise heterodimeric combinations of SNX1 or SNX2 with SNX5 or SNX6 and serve to regulate the biogenesis of tubular endosomal sorting profiles...
  20. Yoon T, Kim M, Lee K. Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6. FEBS Lett. 2006;580:3558-64 pubmed
    ..Our studies led to the identification of sorting nexin 6 (SNX6) which binds with TCTP as a potential negative regulator of TCTP...
  21. Rivera J, Megias D, Bravo J. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. J Cell Biochem. 2010;111:1464-72 pubmed publisher
    b>Sorting nexin 6 (SNX6), a predominantly cytoplasmic protein involved in intracellular trafficking of membrane receptors, was identified as a TGF-? family interactor...
  22. Camargo L, Collura V, Rain J, Mizuguchi K, Hermjakob H, Kerrien S, et al. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry. 2007;12:74-86 pubmed
  23. Gonzalez Granado J, Navarro Puche A, Molina Sánchez P, Blanco Berrocal M, Viana R, Font de Mora J, et al. Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. PLoS ONE. 2014;9:e115571 pubmed publisher
    ..that trafficking of lamin A, but not lamin B1, and its assembly into the nuclear envelope are regulated by sorting nexin 6 (SNX6), a major component of the retromer that targets proteins and other molecules to specific subcellular ..
  24. Ishibashi Y, Maita H, Yano M, Koike N, Tamai K, Ariga H, et al. Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus. FEBS Lett. 2001;506:33-8 pubmed
    ..In this study, we identified tumor necrosis factor receptor-associated factor 4-associated factor 2/sorting nexin 6 (TFAF2/SNX6) as a Pim-1-binding protein, and we found that TFAF2/SNX6 was phosphorylated and translocated ..
  25. Hong Z, Yang Y, Zhang C, Niu Y, Li K, Zhao X, et al. The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Cell Res. 2009;19:1334-49 pubmed publisher
    ..In this study, we found that one of SNX1/2's dimerization partners, SNX6, interacts with the p150(Glued) subunit of the dynein/dynactin motor complex...