Gene Symbol: SNX5
Description: sorting nexin 5
Alias: sorting nexin-5
Species: human
Products:     SNX5

Top Publications

  1. Otsuki T, Kajigaya S, Ozawa K, Liu J. SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. Biochem Biophys Res Commun. 1999;265:630-5 pubmed
    ..b>Sorting nexin 5 (SNX5), a new member of the human SNX family, was identified as a putative FANCA-binding protein...
  2. Teasdale R, Loci D, Houghton F, Karlsson L, Gleeson P. A large family of endosome-localized proteins related to sorting nexin 1. Biochem J. 2001;358:7-16 pubmed
    ..The members of one subgroup, which includes human SNX1, SNX2, SNX4, SNX5 and SNX6 and the yeast Vps5p and YJL036W, all contain coiled-coil regions within their large C-terminal domains and ..
  3. Merino Trigo A, Kerr M, Houghton F, Lindberg A, Mitchell C, Teasdale R, et al. Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. J Cell Sci. 2004;117:6413-24 pubmed
    ..We show here that sorting nexin 5 (SNX5) can be recruited to two distinct membrane compartments...
  4. Yoo K, Kim E, Jung S, Rhee M, Koo B, Yoon K, et al. Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. FEBS Lett. 2006;580:4409-16 pubmed
    ..In this search we identified Sorting nexin 5 (Snx5) as a novel interacting partner of Mind bomb...
  5. Wassmer T, Attar N, Bujny M, Oakley J, Traer C, Cullen P. A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J Cell Sci. 2007;120:45-54 pubmed
    ..Using this screen, we identified two proteins, SNX5 and SNX6, that, when suppressed, induced a phenotype similar to that observed upon suppression of known retromer ..
  6. Hara S, Kiyokawa E, Iemura S, Natsume T, Wassmer T, Cullen P, et al. The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol Biol Cell. 2008;19:3823-35 pubmed publisher
    ..Among these SNX proteins, SNX5 was coimmunoprecipitated with DOCK180 most efficiently...
  7. Itai N, Shimazu T, Kimura T, Ibe I, Yamashita R, Kaburagi Y, et al. The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis. PLoS ONE. 2018;13:e0207205 pubmed publisher
    b>Sorting nexin 5 (SNX5), a member of sorting nexin family, plays an important role in membrane trafficking, including the retrograde trafficking of the cation independent mannose 6-phosphate receptor (CI-M6PR) and macropinocytosis...
  8. Hu X, Fu S, Luo Q, He J, Qiu Y, Lai W, et al. Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury via the GDNF-mediated GDNF/GFRα1/RET signalling pathway. J Biosci. 2018;43:985-1000 pubmed
    ..Recently, microRNA-216a (miR-216a) has been reported to regulate snx5, a novel notch signalling pathway component during retinal development...
  9. Loos M, van der Sluis S, Bochdanovits Z, van Zutphen I, Pattij T, Stiedl O, et al. Activity and impulsive action are controlled by different genetic and environmental factors. Genes Brain Behav. 2009;8:817-28 pubmed publisher
    ..exploration tests; these behavioral measures correlated with the expression of different genes (respectively, Frzb, Snx5, BC056474 and the previously identified Glo1)...

More Information


  1. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..recycling is mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6...
  2. Schuchman R, Kilianski A, Piper A, Vancini R, Ribeiro J, Sprague T, et al. Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virion and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication. J Virol. 2018;92: pubmed publisher
    ..One host protein, sorting nexin 5 (SNX5), was shown to be critical for the replication of three different alphaviruses, Sindbis, Mayaro, and ..
  3. Fazil M, Ong S, Chalasani M, Low J, Kizhakeyil A, Mamidi A, et al. GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells. Sci Rep. 2016;6:37721 pubmed publisher
    ..Internalized GapmeR molecules can associate with SNX5-positive macropinosomes in T-cells, as detected by super-resolution microscopy...
  4. Yong X, Hu W, Zhou X, Wang J, Burstein E, Jia D. Expression and purification of the SNX1/SNX6 complex. Protein Expr Purif. 2018;151:93-98 pubmed publisher
    ..The SNX members SNX1/2 and SNX5/6 form dimers, and mediate endosome-to-trans Golgi network (TGN) transport through coordinating cargo selection and ..
  5. Olena A, Rao M, Thatcher E, Wu S, Patton J. miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development. Dev Biol. 2015;400:72-81 pubmed publisher
    ..Mind bomb (Mib) is a ubiquitin ligase that is required for activation of Notch by Notch׳s ligand, Delta. Sorting Nexin 5 (SNX5) co-localizes with Mib and Delta complexes and has been shown to directly bind to Mib...
  6. Maschkowitz G, Gärtner S, Hofmann Winkler H, Fickenscher H, Winkler M. Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization. J Virol. 2018;92: pubmed publisher
    ..Here we show that sorting nexin 5 (SNX5), a component of the retromer and part of the retrograde transport pathway, interacts with UL35 ..
  7. Elwell C, Czudnochowski N, Von Dollen J, Johnson J, Nakagawa R, Mirrashidi K, et al. Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. elife. 2017;6: pubmed publisher
    ..We previously reported that IncE binds specifically to the Sorting Nexin 5 Phox domain (SNX5-PX) and disrupts retromer trafficking...
  8. Aeberhard L, Banhart S, Fischer M, Jehmlich N, Rose L, Koch S, et al. The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components. PLoS Pathog. 2015;11:e1004883 pubmed publisher
    ..Functional studies showed that in particular, SNX5 controls the C. trachomatis infection and that retrograde trafficking is essential for infectious progeny formation...
  9. Lim J, Gosavi P, Mintern J, Ross E, Gleeson P. Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages. J Cell Sci. 2015;128:4407-19 pubmed publisher
    ..We previously identified sorting nexin 5 (SNX5) as a regulator of macropinocytosis in macrophages...
  10. Sun Y, Hedman A, Tan X, Schill N, Anderson R. Endosomal type I? PIP 5-kinase controls EGF receptor lysosomal sorting. Dev Cell. 2013;25:144-55 pubmed publisher
    ..In this pathway, PIPKI?i5 interacts with sorting nexin 5 (SNX5), a protein that binds PtdIns4,5P(2) and other phosphoinositides...
  11. Simonetti B, Danson C, Heesom K, Cullen P. Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. J Cell Biol. 2017;216:3695-3712 pubmed publisher
    ..The retromer-linked SNX-BAR proteins comprise heterodimeric combinations of SNX1 or SNX2 with SNX5 or SNX6 and serve to regulate the biogenesis of tubular endosomal sorting profiles...
  12. Kvainickas A, Jimenez Orgaz A, Nägele H, Hu Z, Dengjel J, Steinberg F. Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. J Cell Biol. 2017;216:3677-3693 pubmed publisher
    ..In this study, we demonstrate that heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the ..
  13. Mirrashidi K, Elwell C, Verschueren E, Johnson J, Frando A, Von Dollen J, et al. Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. Cell Host Microbe. 2015;18:109-21 pubmed publisher
    ..IncE binds to sorting nexins (SNXs) 5/6, components of the retromer, which relocalizes SNX5/6 to the inclusion membrane and augments inclusion membrane tubulation...
  14. Ara S, Kikuchi T, Matsumiya H, Kojima T, Kubo T, Ye R, et al. Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2. Cancer Sci. 2012;103:1356-62 pubmed publisher
    ..Expression profiles of SNX family members of PTC showed a significant quantity of transcripts of SNX5. Further immunohistochemical analysis with an SNX5-specific monoclonal antibody established in this study ..
  15. Villar V, Armando I, Sanada H, Frazer L, Russo C, Notario P, et al. Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension. FASEB J. 2013;27:1808-19 pubmed publisher
    ..We now report the discovery of a dynamic interaction between sorting nexin 5 (SNX5), a component of the mammalian retromer, and D1R in human renal epithelial cells...
  16. Wang J, Ci Y, Liu C, Sun H. Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells. Genet Mol Res. 2017;16: pubmed publisher
    ..However, western blotting revealed expression of T1?, Aqp5, and Snx5 {type I alveolar epithelial cell markers} in Mac-1-/- mice to be significantly decreased {P < 0.05}...
  17. Tan X, Sun Y, Thapa N, Liao Y, Hedman A, Anderson R. LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation. EMBO J. 2015;34:475-90 pubmed publisher
    ..and neutralizes the inhibitory function of LAPTM4B in EGFR sorting by generating PtdIns(4,5)P2 and recruiting SNX5. PtdIns(4,5)P2 and SNX5 function together to protect Hrs from ubiquitination, thereby promoting EGFR intraluminal ..
  18. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
    ..retromers whose membrane-bound subcomplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6...
  19. Maruzs T, Lőrincz P, Szatmári Z, Széplaki S, Sándor Z, Lakatos Z, et al. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Traffic. 2015;16:1088-107 pubmed publisher
    ..Finally, we find that Snx3 and Snx6 are also required for proper autolysosomal degradation in Drosophila larval fat body cells. ..
  20. Li F, Yang J, Jones J, Villar V, Yu P, Armando I, et al. Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology. 2015;156:2211-21 pubmed publisher
    b>Sorting nexin 5 (SNX5) belongs to the SNX family, which is composed of a diverse group of proteins that mediate trafficking of plasma membrane proteins, receptors, and transporters...
  21. So J, Kim J, Yoo K, Kim H, Jung S, Choi J, et al. FIH-1, a novel interactor of mindbomb, functions as an essential anti-angiogenic factor during zebrafish vascular development. PLoS ONE. 2014;9:e109517 pubmed publisher
    ..Taken together, our data suggest that FIH-1 interacts with Mib E3 Ubiquitin ligase and modulates vascular development by attenuating VEGF-A signaling activity. ..
  22. Paul B, Kim H, Kerr M, Huston W, Teasdale R, Collins B. Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis. elife. 2017;6: pubmed publisher
    ..Crystal structures of the SNX5 phox-homology (PX) domain in complex with IncE define the precise molecular basis for these interactions...
  23. Jitsukawa S, Kamekura R, Kawata K, Ito F, Sato A, Matsumiya H, et al. Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression. J Pathol. 2017;243:342-353 pubmed publisher
    ..We previously reported that the level of sorting nexin 5 (Snx5), an endosomal translocator, is preferentially decreased during the progression of well-differentiated ..
  24. Trousdale C, Kim K. Retromer: Structure, function, and roles in mammalian disease. Eur J Cell Biol. 2015;94:513-21 pubmed publisher
    ..These five proteins (Vps5, Vps17, Vps26, Vps29, and Vps35 in yeast and SNX1/2, SNX5/6, Vps26, Vps29, and Vps35 in mammalian cells) act as a coat for vesicles budding off of the endosome, as well as ..
  25. Li F, Yang J, Villar V, Asico L, Ma X, Armando I, et al. Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice. Diabetologia. 2018;61:727-737 pubmed publisher
    We hypothesised that renal sorting nexin 5 (SNX5) regulates the insulin-degrading enzyme (IDE) and, thus, circulating insulin levels...
  26. Lim J, Wang J, Kerr M, Teasdale R, Gleeson P. A role for SNX5 in the regulation of macropinocytosis. BMC Cell Biol. 2008;9:58 pubmed publisher
    ..Here we have investigated the role of sorting nexin 5 (SNX5) in the regulation of macropinocytic activity...
  27. Towler M, Gleeson P, Hoshino S, Rahkila P, Manalo V, Ohkoshi N, et al. Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Mol Biol Cell. 2004;15:3181-95 pubmed
    ..CHC22 binds to sorting nexin 5 through a coiled-coil domain present in both partners, which is absent in CHC17 and coincides with the region ..