Gene Symbol: SNX4
Description: sorting nexin 4
Alias: ATG24B, sorting nexin-4
Species: human
Products:     SNX4

Top Publications

  1. Haft C, de la Luz Sierra M, Barr V, Haft D, Taylor S. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol. 1998;18:7278-87 pubmed
    ..amino acid sequences of three novel homologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4). In addition, we identified a presumed splice variant isoform of SNX1 (SNX1A)...
  2. Skånland S, Walchli S, Utskarpen A, Wandinger Ness A, Sandvig K. Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. Traffic. 2007;8:297-309 pubmed
    ..Furthermore, we identify two effector proteins in the hVps34-dependent pathway, namely sorting nexin (SNX) 2 and SNX4. Knockdown of SNX2 or SNX4 inhibits ricin transport to the Golgi apparatus to the same extent as when hVps34 is ..
  3. Leprince C, Le Scolan E, Meunier B, Fraisier V, Brandon N, de Gunzburg J, et al. Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci. 2003;116:1937-48 pubmed
    ..One of the interacting clones corresponded to sorting nexin 4 (SNX4), a member of the SNX family of proteins which are suspected to regulate vesicular trafficking...
  4. Skånland S, Walchli S, Brech A, Sandvig K. SNX4 in complex with clathrin and dynein: implications for endosome movement. PLoS ONE. 2009;4:e5935 pubmed publisher
    ..Some members regulate intracellular trafficking. We have here investigated mechanisms underlying SNX4 mediated endosome to Golgi transport. We show that SNX4 forms complexes with clathrin and dynein...
  5. van Weering J, Verkade P, Cullen P. SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation. Traffic. 2012;13:94-107 pubmed publisher
    ..the localization of SNX1 [endosome-to-trans-Golgi network (TGN) transport as part of the SNX-BAR-retromer complex], SNX4 (cargo-recycling from endosomes to the plasma membrane) and SNX8 (endosomes-to-TGN trafficking in a retromer-..
  6. Traer C, Rutherford A, Palmer K, Wassmer T, Oakley J, Attar N, et al. SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. Nat Cell Biol. 2007;9:1370-80 pubmed
    ..Here, we establish that through its phox homology (PX) and Bin-Amphiphysin-Rvs (BAR) domains, sorting nexin-4 (SNX4) is associated with tubular and vesicular elements of a compartment that overlaps with peripheral early endosomes ..
  7. Ma M, Kumar S, Purushothaman L, Babst M, Ungermann C, Chi R, et al. Lipid trafficking by yeast Snx4 family SNX-BAR proteins promotes autophagy and vacuole membrane fusion. Mol Biol Cell. 2018;29:2190-2200 pubmed publisher
    ..In yeast ( Saccharomyces cerevisiae) cells, several selective autophagy pathways fail in cells lacking the dimeric Snx4/Atg24 and Atg20/Snx42 sorting nexins containing a BAR domain (SNX-BARs), which function as coat proteins of ..
  8. Brennand A, Rico E, Rigden D, Van Der Smissen P, Courtoy P, Michels P. ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei. PLoS ONE. 2015;10:e0130365 pubmed publisher
    ..We therefore characterized T. brucei ATG24, the T. brucei ortholog of yeast Atg24 and mammalian SNX4, and found it to have a regulatory role in autophagy and differentiation as well as endocytic trafficking...
  9. Bean B, Davey M, Conibear E. Cargo selectivity of yeast sorting nexins. Traffic. 2017;18:110-122 pubmed publisher
    ..Nine hits whose sorting was dependent on Snx4, the sorting nexin-containing retromer complex, or both retromer and Snx3, were examined in detail to search for ..

More Information


  1. Ma M, Burd C, Chi R. Distinct complexes of yeast Snx4 family SNX-BARs mediate retrograde trafficking of Snc1 and Atg27. Traffic. 2017;18:134-144 pubmed publisher
    The yeast SNX4 sub-family of sorting nexin containing a Bin-Amphiphysin-Rvs domain (SNX-BAR) proteins, Snx4/Atg24, Snx41 and Atg20/Snx42, are required for endocytic recycling and selective autophagy...
  2. Suzuki S, Emr S. Membrane protein recycling from the vacuole/lysosome membrane. J Cell Biol. 2018;217:1623-1632 pubmed publisher
    ..First, Atg27 is recycled from the vacuole to the endosome via the Snx4 complex and then from the endosome to the Golgi via the retromer complex...
  3. Zhao D, Liu X, Yu Z, Sun L, Xiong X, Dong M, et al. Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast. J Cell Sci. 2016;129:4289-4304 pubmed
    ..11 (named here as Atg24b)...
  4. Sander L, Frank S, Bolat S, Blank U, Galli T, Bigalke H, et al. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol. 2008;38:855-63 pubmed publisher
    ..In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation...
  5. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases. ..
  6. Kim N, Cho M, Won S, Kang H, Yoon S, Kim D. Sorting nexin-4 regulates ?-amyloid production by modulating ?-site-activating cleavage enzyme-1. Alzheimers Res Ther. 2017;9:4 pubmed publisher
    ..Although sorting nexin (SNX) family proteins regulate this trafficking, the relevance and role of sorting nexin-4 (SNX4) regarding AD has not been studied yet...
  7. Wurthner J, Frank D, Felici A, Green H, Cao Z, Schneider M, et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem. 2001;276:19495-502 pubmed
  8. van Weering J, Sessions R, Traer C, Kloer D, Bhatia V, Stamou D, et al. Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J. 2012;31:4466-80 pubmed publisher
    ..Our data provide insight into the molecular mechanism that generates and organizes the tubular endosomal network...
  9. Sakane H, Horii Y, Nogami S, Kawano Y, Kaneko Kawano T, Shirataki H. ?-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor. PLoS ONE. 2014;9:e93509 pubmed publisher
    ..Taxilin was immunoprecipitated with sorting nexin 4 (SNX4), which is involved in the recycling of TfnR...
  10. Nemec A, Howell L, Peterson A, Murray M, Tomko R. Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4. J Biol Chem. 2017;292:21466-21480 pubmed publisher
    ..A targeted screen of autophagy genes identified a requirement for the conserved sorting nexin Snx4 in the autophagic turnover of proteasomes and several other large multisubunit complexes...
  11. Toh W, Chia P, Hossain M, Gleeson P. GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production. Mol Biol Cell. 2018;29:191-208 pubmed publisher
    ..assessed the transport of BACE1 from early to recycling endosomes and have identified essential roles for the sorting nexin 4 (SNX4)-mediated, signal-independent pathway and for a novel signal-mediated pathway...
  12. Yang S, Rosenwald A. A High Copy Suppressor Screen for Autophagy Defects in Saccharomyces arl1Δ and ypt6Δ Strains. G3 (Bethesda). 2017;7:333-341 pubmed publisher
    ..From the screen results, we selected COG4, SNX4, TAX4, IVY1, PEP3, SLT2, and ATG5, either membrane traffic or autophagy ..
  13. Popelka H, Damasio A, Hinshaw J, Klionsky D, Ragusa M. Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction. Proc Natl Acad Sci U S A. 2017;114:E10112-E10121 pubmed publisher
    The Atg20 and Snx4/Atg24 proteins have been identified in a screen for mutants defective in a type of selective macroautophagy/autophagy...