Gene Symbol: SNX3
Description: sorting nexin 3
Alias: Grd19, MCOPS8, SDP3, sorting nexin-3, sorting nexin 3A
Species: human
Products:     SNX3

Top Publications

  1. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..We have found that the unrelated sorting nexin, SNX3, has an evolutionarily conserved function in Wls recycling and Wnt secretion and show that SNX3 interacts directly ..
  2. Xu Y, Hortsman H, Seet L, Wong S, Hong W. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol. 2001;3:658-66 pubmed
    ..We show that SNX3 is associated with the early endosome through a novel motif (PX domain) capable of interaction with ..
  3. Vervoort V, Viljoen D, Smart R, Suthers G, DuPont B, Abbott A, et al. Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype. J Med Genet. 2002;39:893-9 pubmed
    ..Southern blot analysis allowed us to determine that the sorting nexin 3 gene (SNX3) was disrupted...
  4. Haft C, de la Luz Sierra M, Barr V, Haft D, Taylor S. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol. 1998;18:7278-87 pubmed
    ..deduced the amino acid sequences of three novel homologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4). In addition, we identified a presumed splice variant isoform of SNX1 (SNX1A)...
  5. Braun V, Wong A, Landekic M, Hong W, Grinstein S, Brumell J. Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole. Cell Microbiol. 2010;12:1352-67 pubmed publisher
    ..We therefore studied whether sorting nexins, particularly sorting nexin 3 (SNX3), play a role in Salmonella infection...
  6. Pons V, Luyet P, Morel E, Abrami L, van der Goot F, Parton R, et al. Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 2008;6:e214 pubmed publisher
    ..By contrast, we find that the PtdIns3P-binding protein SNX3 is required for multivesicular body formation, but not for EGF receptor degradation...
  7. Cui Y, Carosi J, Yang Z, Ariotti N, Kerr M, Parton R, et al. Retromer has a selective function in cargo sorting via endosome transport carriers. J Cell Biol. 2019;218:615-631 pubmed publisher
    ..Finally, we show that this retromer-dependent retrograde cargo trafficking pathway requires SNX3, but not other retromer-associated cargo binding proteins, such as SNX27 or SNX-BAR proteins...
  8. Kovtun O, Leneva N, Bykov Y, Ariotti N, Teasdale R, Schaffer M, et al. Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature. 2018;561:561-564 pubmed publisher
    ..Vps5 binds to Vps26 at a position analogous to the previously described cargo- and Snx3-binding site, which suggests the existence of distinct retromer-sorting nexin assemblies...
  9. Overduin M, Rajesh S, Gruenberg J, Lenoir M. Secondary structure and (1)H, (13)C, (15)N resonance assignments of the endosomal sorting protein sorting nexin 3. Biomol NMR Assign. 2015;9:355-8 pubmed publisher
    b>Sorting nexin 3 (SNX3) belongs to a sub-family of sorting nexins that primarily contain a single Phox homology domain capable of binding phosphoinositides and membranes...

More Information


  1. McGough I, de Groot R, Jellett A, Betist M, Varandas K, Danson C, et al. SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. Nat Commun. 2018;9:3737 pubmed publisher
    ..Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway...
  2. Seaman M, Mukadam A, Breusegem S. Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex. J Cell Sci. 2018;131: pubmed publisher
    ..a trimeric complex comprising VPS35, VPS29 and VPS26, which is recruited to endosomes by binding to Rab7a and Snx3. Retromer function is linked to two distinct neurodegenerative diseases, Parkinson's disease and Alzheimer's ..
  3. Strochlic T, Setty T, Sitaram A, Burd C. Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J Cell Biol. 2007;177:115-25 pubmed
    ..Fet3p-Ftr1p is maintained on the plasma membrane via an endocytic recycling pathway requiring the sorting nexin Grd19/Snx3p, the pentameric retromer complex, and the Ypt6p Golgi Rab GTPase module...
  4. Xu S, Nigam S, Brodin L. Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein. Neurodegener Dis. 2018;18:26-37 pubmed publisher
    ..Recently, single-nucleotide polymorphisms in SNX3 were found to be associated with Alzheimer disease...
  5. Lenoir M, Ustunel C, Rajesh S, Kaur J, Moreau D, Gruenberg J, et al. Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting. Nat Commun. 2018;9:993 pubmed publisher
    ..The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate ..
  6. Dehghan Nayeri N, Rezaei Tavirani M, Omrani M, Gharehbaghian A, Goudarzi Pour K, Eshghi P. Identification of potential predictive markers of dexamethasone resistance in childhood acute lymphoblastic leukemia. J Cell Commun Signal. 2017;11:137-145 pubmed publisher
    ..three differentially expressed proteins were detected, including voltage dependent anion channel 1 (VDAC1), sorting Nexin 3 (SNX3), and prefoldin subunit 6 (PFDN6)...
  7. Dalton L, Bean B, Davey M, Conibear E. Quantitative high-content imaging identifies novel regulators of Neo1 trafficking at endosomes. Mol Biol Cell. 2017;28:1539-1550 pubmed publisher
    ..We further showed that the cargo-selective sorting nexin Snx3 is required for Neo1 trafficking and identified an Snx3 sorting motif in the Neo1 N-terminus...
  8. Bean B, Davey M, Conibear E. Cargo selectivity of yeast sorting nexins. Traffic. 2017;18:110-122 pubmed publisher
    ..Nine hits whose sorting was dependent on Snx4, the sorting nexin-containing retromer complex, or both retromer and Snx3, were examined in detail to search for potential sorting motifs...
  9. Maruzs T, Lőrincz P, Szatmári Z, Széplaki S, Sándor Z, Lakatos Z, et al. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Traffic. 2015;16:1088-107 pubmed publisher
    ..Finally, we find that Snx3 and Snx6 are also required for proper autolysosomal degradation in Drosophila larval fat body cells.
  10. Lucas M, Gershlick D, Vidaurrazaga A, Rojas A, Bonifacino J, Hierro A. Structural Mechanism for Cargo Recognition by the Retromer Complex. Cell. 2016;167:1623-1635.e14 pubmed publisher
    ..analysis of a four-component complex comprising the VPS26 and VPS35 subunits of retromer, the sorting nexin SNX3, and a recycling signal from the divalent cation transporter DMT1-II...
  11. Harrison M, Hung C, Liu T, Christiano R, Walther T, Burd C. A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A. 2014;111:267-72 pubmed publisher
    ..We show that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, SNX3, and the RAB7A GTPase, by the VPS35 retromer subunit...
  12. Chua R, Wong S. SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells. Immunology. 2013;139:30-47 pubmed publisher
    ..We hypothesized that SNX3, a small sorting nexin that contains a single PI3P lipid-binding PX domain as its only protein domain, localizes to ..
  13. Kumar R, Everman D, Morgan C, Slavotinek A, Schwartz C, Simpson E. Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes. BMC Med Genet. 2007;8:48 pubmed
    A disruption of sorting nexin 3 (SNX3) on 6q21 was previously reported in a patient with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and t(6;13)(q21;q12) but no SNX3 mutations were identified in another sporadic ..
  14. Dong H, Yuan H, Jin W, Shen Y, Xu X, Wang H. Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2. Acta Biochim Biophys Sin (Shanghai). 2007;39:540-6 pubmed
    ..assay with the juxtamembrane and membrane-proximal catalytic domain of PCP-2 as "bait" Both AP-3 and SNX3 are molecules involved in intracellular trafficking of membrane receptors...
  15. Zhong Q, Watson M, Lazar C, Hounslow A, Waltho J, Gill G. Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell. 2005;16:2049-57 pubmed
    ..Thus, the obligate dimerization of SNX1 that is driven by the C-terminal domain creates a high-affinity PI binding species that properly targets the holo protein to endosomes. ..
  16. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases. ..
  17. Yang W, Pan B, Zhang T, Wang Z, Zhang L, Guo Y. [The morphological changes of SW620 cells induced by over-expression of human sorting nexin 3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:1057-61 pubmed
    To explore the effect of human sorting nexin 3 (hSNX3) on the morphology and migration of colorectal cancer cells through over-expression of hSNX3 in SW620 cells...
  18. Vardarajan B, Bruesegem S, Harbour M, Inzelberg R, FRIEDLAND R, St George Hyslop P, et al. Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging. 2012;33:2231.e15-2231.e30 pubmed publisher
    ..We obtained significant evidence of association with KIAA1033 (VEGAS p = 0.025), SNX1 (VEGAS p = 0.035), SNX3 (p = 0.0057), and RAB7A (VEGAS p = 0.018)...
  19. Nooh M, Bahouth S. Two barcodes encoded by the type-1 PDZ and by phospho-Ser312 regulate retromer/WASH-mediated sorting of the ß1-adrenergic receptor from endosomes to the plasma membrane. Cell Signal. 2017;29:192-208 pubmed publisher
    ..of WT ß1-AR or WT ß2-AR was dependent on targeting the retromer to endosomal membranes via SNX3 and rab7a, and on complexing the retromer to the WASH pentamer via the C-tail of FAM21 (FAM21C)...
  20. Pons V, Ustunel C, Rolland C, Torti E, Parton R, Gruenberg J. SNX12 role in endosome membrane transport. PLoS ONE. 2012;7:e38949 pubmed publisher
    ..SNX12 is a member of the PX domain-containing sorting nexin family and shares high homology with SNX3, which plays a central role in the formation of intralumenal vesicles within multivesicular endosomes...
  21. Feng S, Streets A, Nesin V, Tran U, Nie H, Onopiuk M, et al. The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex. J Am Soc Nephrol. 2017;28:2973-2984 pubmed publisher
    ..and cellular assays, we determined that PC2 binds two isoforms of the retromer-associated protein sorting nexin 3 (SNX3), including a novel isoform that binds PC2 in a direct manner...
  22. Boulkroun S, Ruffieux Daidié D, Vitagliano J, Poirot O, Charles R, Lagnaz D, et al. Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. Am J Physiol Renal Physiol. 2008;295:F889-900 pubmed publisher
    ..A two-hybrid screen identified sorting nexin 3 (SNX3) as a novel substrate of Usp10...
  23. Chiow K, Tan Y, Chua R, Huang D, Ng M, Torta F, et al. SNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells. Cell Mol Life Sci. 2012;69:1505-21 pubmed publisher
    ..Further elucidation of the mechanism suggests that aspirin enhances recruitment of SNX3 and SNX5 to membranes and consistently, both SNX3 and SNX5 play essential roles in the aspirin-mediated ..