SNX27

Summary

Gene Symbol: SNX27
Description: sorting nexin family member 27
Alias: MRT1, MY014, sorting nexin-27, methamphetamine-responsive transcript 1
Species: human
Products:     SNX27

Top Publications

  1. Cai L, Loo L, Atlashkin V, Hanson B, Hong W. Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C). Mol Cell Biol. 2011;31:1734-47 pubmed publisher
    ..b>Sorting nexin 27 (SNX27) is unique, as it contains a PDZ (Psd-95/Dlg/ZO1) domain...
  2. Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, et al. New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. J Cell Sci. 2004;117:5367-79 pubmed
    ..with both the constitutive and inducible (upon methamphetamine treatment) forms of the recently cloned sorting nexin 27 (SNX27a and b, respectively). We found that SNX27a redirected part of 5-HT4(a)R to early endosomes...
  3. Rincón E, Santos T, Avila Flores A, Albar J, Lalioti V, Lei C, et al. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. Mol Cell Proteomics. 2007;6:1073-87 pubmed
    ..used a proteomics approach to search for novel diacylglycerol kinase zeta-interacting proteins and identified sorting nexin 27 (SNX27), a recently described member of a protein family involved in intracellular trafficking, which has a ..
  4. Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan N, von Zastrow M. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol. 2011;13:715-21 pubmed publisher
    ..Furthermore, we show that sorting nexin 27 (SNX27) serves as an essential adaptor protein linking ?2ARs to the retromer tubule...
  5. Lunn M, Nassirpour R, Arrabit C, Tan J, McLeod I, Arias C, et al. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat Neurosci. 2007;10:1249-59 pubmed
    ..Using a proteomics approach, we have identified a unique rodent intracellular protein, sorting nexin 27 (SNX27), which regulates the trafficking of Kir3 channels...
  6. Hayashi H, Naoi S, Nakagawa T, Nishikawa T, Fukuda H, Imajoh Ohmi S, et al. Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4. J Biol Chem. 2012;287:15054-65 pubmed publisher
    ..This method identified sorting nexin 27 (SNX27) as the interacting PDZ adaptor protein with a PDZ-binding motif of MRP4...
  7. MacNeil A, Mansour M, Pohajdak B. Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. Biochem Biophys Res Commun. 2007;359:848-53 pubmed
    ..Using GST pulldowns and mass spectrometry we identified the novel interaction of CASP and sorting nexin 27 (SNX27). In lymphocytes, CASP's PDZ-binding motif interacts with the PDZ domain of SNX27...
  8. Steinberg F, Gallon M, Winfield M, Thomas E, Bell A, Heesom K, et al. A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nat Cell Biol. 2013;15:461-71 pubmed publisher
    The PDZ-domain-containing sorting nexin 27 (SNX27) promotes recycling of internalized transmembrane proteins from endosomes to the plasma membrane by linking PDZ-dependent cargo recognition to retromer-mediated transport...
  9. Nassirpour R, Slesinger P. Subunit-specific regulation of Kir3 channels by sorting nexin 27. Channels (Austin). 2007;1:331-3 pubmed
    ..Using a proteomics approach, we recently discovered that sorting nexin 27 (SNX27) associates with a subset of Kir3 channels...

More Information

Publications64

  1. Lauffer B, Melero C, Temkin P, Lei C, Hong W, Kortemme T, et al. SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J Cell Biol. 2010;190:565-74 pubmed publisher
    ..Here, we show that sorting nexin 27 (SNX27) is required for efficient PDZ-directed recycling of the beta(2)-adrenoreceptor (beta(2)AR) from early ..
  2. Merida I, Arranz Nicolás J, Rodríguez Rodríguez C, Avila Flores A. Diacylglycerol kinase control of protein kinase C. Biochem J. 2019;476:1205-1219 pubmed publisher
    ..In T lymphocytes, DGKζ interaction with Sorting Nexin 27 (SNX27) guarantees the basal control of PKCα activation...
  3. Dufreneix F, Faverdin P, Peyraud J. Influence of particle size and density on mean retention time in the rumen of dairy cows. J Dairy Sci. 2019;102:3010-3022 pubmed publisher
    ..fitted to a double exponential model to calculate total MRT in the digestive tract (TMRT), MRT in 2 compartments (MRT1 and MRT2), and retention time in the intestines' tubular section (TT)...
  4. Strutt H, Langton P, Pearson N, McMillan K, Strutt D, Cullen P. Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions. Curr Biol. 2019;29:484-491.e6 pubmed publisher
    ..Through generation of mutants, we verify that loss of the retromer-associated Snx27 cargo adaptor, but notably not components of the Wash complex, reduces junctional levels of the core proteins ..
  5. Binda C, Nakamura Y, Henley J, Wilkinson K. Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number. Biochem J. 2019;: pubmed publisher
    ..or through an adaptor protein, the most well-characterised of which is the PDZ domain-containing sorting nexin SNX27. Neuroligins (NLGs) are postsynaptic trans-synaptic scaffold proteins that function in the clustering of ..
  6. Cui Y, Carosi J, Yang Z, Ariotti N, Kerr M, Parton R, et al. Retromer has a selective function in cargo sorting via endosome transport carriers. J Cell Biol. 2019;218:615-631 pubmed publisher
    ..cargo trafficking pathway requires SNX3, but not other retromer-associated cargo binding proteins, such as SNX27 or SNX-BAR proteins...
  7. Singh V, Yang J, Cha B, Chen T, Sarker R, Yin J, et al. Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3. Mol Biol Cell. 2015;26:2030-43 pubmed publisher
    b>Sorting nexin 27 (SNX27) contains a PDZ domain that is phylogenetically related to the PDZ domains of the NHERF proteins...
  8. Rifkin R, Huyghe D, Li X, Parakala M, Aisenberg E, Moss S, et al. GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization. Proc Natl Acad Sci U S A. 2018;115:E9479-E9488 pubmed publisher
    ..We used sorting nexin 27 (SNX27), an endosomal adaptor protein that associates with GIRK2c and GIRK3 subunits, to probe the role of ..
  9. Gomez Iturriaga A, Casquero F, Pijoan J, Crook J, Urresola A, Ezquerro A, et al. Pretreatment Multiparametric Magnetic Resonance Imaging Findings Are More Accurate Independent Predictors of Outcome Than Clinical Variables in Localized Prostate Cancer. Int J Radiat Oncol Biol Phys. 2018;101:1172-1178 pubmed publisher
    ..The median age was 71 years (range 56-82). Of the patients, 20.5% had mpMRI-determined (mrT) stage mrT1-mrT2b, 37.3% had mrT2c, 31% had mrT3a, and 11.2% had mrT3b. The Gleason score was 6 in 22.2%, 7 in 49...
  10. Wermke M, Camgoz A, Paszkowski Rogacz M, Thieme S, von Bonin M, Dahl A, et al. RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug. Blood. 2015;125:3760-8 pubmed publisher
    ..Stringent validation identified 6 genes (BNIPL1, ROCK1, RPS13, STK3, SNX27, WDHD1) whose knockdown impaired growth and viability of the cells...
  11. Zimmerman S, Hueschen C, Malide D, Milgram S, Playford M. Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial tight junction. Biochem J. 2013;455:95-106 pubmed publisher
    ..b>SNX27 is the only sorting nexin that contains a PDZ domain...
  12. Singh V, Yang J, Yin J, Cole R, Tse M, Berman D, et al. Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane. J Cell Sci. 2018;131: pubmed publisher
    ..We now describe that CT phosphorylates an amino acid in the PDZ domain of SNX27, which inhibits SNX27-mediated trafficking of NHE3 from the early endosomes to the plasma membrane (PM), and ..
  13. Yang Z, Follett J, Kerr M, Clairfeuille T, Chandra M, Collins B, et al. Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2. J Biol Chem. 2018;293:6802-6811 pubmed publisher
    ..ASCT2 as a membrane-trafficked cargo molecule, sorted through a direct interaction with the PDZ domain of sorting nexin 27 (SNX27)...
  14. McMillan K, Gallon M, Jellett A, Clairfeuille T, Tilley F, McGough I, et al. Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. J Cell Biol. 2016;214:389-99 pubmed publisher
    ..In particular, we describe a selective defect in the association of VPS26A (p.K297X) with the SNX27 cargo adaptor...
  15. Merkulova M, Păunescu T, Azroyan A, Marshansky V, Breton S, Brown D. Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation. Sci Rep. 2015;5:14827 pubmed publisher
    ..ARHGEF7, DMXL1, EZR, NCOA7, OXR1, RPS6KA3, SNX27 and 9 subunits of the chaperonin containing TCP1 complex (CCT) were found to interact with V-ATPase for the first ..
  16. Chan A, Clairfeuille T, Landao Bassonga E, Kinna G, Ng P, Loo L, et al. Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth. Mol Biol Cell. 2016;27:1367-82 pubmed publisher
    ..Here we show that sorting nexin 27 (SNX27) functions as an adaptor that couples PTHR to the retromer trafficking complex...
  17. Lin T, Lai C, Hsieh M, Wang H, Cheng J, Chau Y, et al. VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn Neurons Mediates Neuropathic Pain in Rats. J Neurosci. 2015;35:14943-55 pubmed publisher
    ..We observed it accompanied by behavioral allodynia; neuropathic injury time-dependently enhanced VPS26A and SNX27 expression; VPS26A-SNX27 coprecipitation; and VPS26A-positive, SNX27-positive, and VPS26A-SNX27 double-labeled ..
  18. Tello Lafoz M, Ghai R, Collins B, Mérida I. A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse. Bioarchitecture. 2014;4:215-20 pubmed publisher
    b>SNX27 is a member of the sorting nexin family that plays an important role in the recycling of receptors from endosomes to the cell surface...
  19. Nooh M, Mancarella S, Bahouth S. Identification of novel transplantable GPCR recycling motif for drug discovery. Biochem Pharmacol. 2016;120:22-32 pubmed publisher
    ..This construct trafficked in a PDZ-SNX27/retromer-independent manner...
  20. Bahouth S, Nooh M. Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks. Cell Signal. 2017;36:42-55 pubmed publisher
    ..While endosomal SNX27, retromer/WASH complexes and actin were required for efficient sorting and budding of all these GPCR, additional ..
  21. Rasulov A, Mamedli Z, Gordeyev S, Kozlov N, Dzhumabaev H. Short-term outcomes after transanal and laparoscopic total mesorectal excision for rectal cancer. Tech Coloproctol. 2016;20:227-34 pubmed publisher
    ..From October 2013 to January 2015, consecutive patients undergoing transanal or laparoscopic TME for biopsy-proven mrT1-4aN0-2M0 rectal cancer were included in a prospective database...
  22. Buenaventura T, Kanda N, Douzenis P, Jones B, Bloom S, Chabosseau P, et al. A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells. Diabetes. 2018;67:385-399 pubmed publisher
    ..We identify five (clathrin, dynamin1, AP2, sorting nexins [SNX] SNX27, and SNX1) that increase and four (huntingtin-interacting protein 1 [HIP1], HIP14, GASP-1, and Nedd4) that ..
  23. Wang X, Zhou Y, Wang J, Tseng I, Huang T, Zhao Y, et al. SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. J Neurosci. 2016;36:12586-12597 pubmed
    ..b>SNX27 is a trafficking component required for normal brain function and was shown previously to suppress ?-secretase-..
  24. Schaletzki Y, Kromrey M, Bröderdorf S, Hammer E, Grube M, Hagen P, et al. Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells. Thromb Haemost. 2017;117:105-115 pubmed publisher
    ..scaffold proteins ezrin-binding protein 50 (EBP50/NHERF1), postsynaptic density protein 95 (PSD95), and sorting nexin 27 (SNX27), but also the adaptor protein complex 3 subunit β3A (AP3B1) and the heat shock protein HSP90 as ..
  25. Huang T, Zhao Y, Li X, Wang X, Tseng I, Thompson R, et al. SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. J Neurosci. 2016;36:7996-8011 pubmed publisher
    ..Here, we report that SNX27, an endosomal trafficking/recycling factor and a negative regulator of the ?-secretase complex, binds to the SORLA ..
  26. Pavlos N, Friedman P. GPCR Signaling and Trafficking: The Long and Short of It. Trends Endocrinol Metab. 2017;28:213-226 pubmed publisher
    ..and trafficking with a focus on the parathyroid hormone receptor (PTHR) as a prototype, and on the actin-sorting nexin 27 (SNX27)-retromer tubule (ASRT) complex, an endosomal sorting hub responsible for recycling and preservation ..
  27. Shinde S, Maddika S. PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly. Cell Rep. 2017;21:1655-1666 pubmed publisher
    ..PTEN physically interacts with SNX27, a component of the retromer complex that recycles transmembrane receptors such as GLUT1 from endosomes to the ..
  28. McGarvey J, Xiao K, Bowman S, Mamonova T, Zhang Q, Bisello A, et al. Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling. J Biol Chem. 2016;291:10986-1002 pubmed publisher
    ..Mass spectrometry identified sorting nexin 27 (SNX27) in isolated endosomes as a PTHR binding partner. PTH treatment enriched endosomal PTHR...
  29. Damseh N, Danson C, Al Ashhab M, Abu Libdeh B, Gallon M, Sharma K, et al. A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration. Neurogenetics. 2015;16:215-221 pubmed publisher
    ..Using exome analysis, we identified a homozygous deleterious mutation in SNX27, which encodes sorting nexin 27, a retromer cargo adaptor...
  30. Valdes J, Tang J, McDermott M, Kuo J, Zimmerman S, Wincovitch S, et al. Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (?-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction. J Biol Chem. 2011;286:39403-16 pubmed publisher
    b>Sorting nexin 27 (SNX27) is a 62-kDa protein localized to early endosomes and known to regulate the intracellular trafficking of ion channels and receptors...
  31. Follett J, Bugarcic A, Yang Z, Ariotti N, Norwood S, Collins B, et al. Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces ?-Synuclein Aggregation. J Biol Chem. 2016;291:18283-98 pubmed publisher
  32. Nooh M, Bahouth S. Two barcodes encoded by the type-1 PDZ and by phospho-Ser312 regulate retromer/WASH-mediated sorting of the ß1-adrenergic receptor from endosomes to the plasma membrane. Cell Signal. 2017;29:192-208 pubmed publisher
    ..Knockdown of the trans-acting PDZ protein sorting nexin27 (SNX27) inhibited the recycling of WT ß1-AR and WT ß2-AR, but had no effect on (S312D) ß1
  33. Lee S, Chang J, Blackstone C. FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus. Nat Commun. 2016;7:10939 pubmed publisher
    ..Retromer organizes the endosomal sorting pathway in conjunction with various sorting nexin (SNX) proteins. The SNX27-retromer complex has recently been identified as a major endosomal hub that regulates endosome-to-plasma membrane ..
  34. Ganti K, Massimi P, Manzo Merino J, Tomaic V, Pim D, Playford M, et al. Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways. PLoS Pathog. 2016;12:e1005854 pubmed publisher
    ..Here we show that this motif allows E6 interaction with Sorting Nexin 27 (SNX27), an essential component of endosomal recycling pathways...
  35. Worby C, Dixon J. Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol. 2002;3:919-31 pubmed
    ..It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking. ..
  36. Meraviglia V, Ulivi A, Boccazzi M, Valenza F, Fratangeli A, Passafaro M, et al. SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation. Glia. 2016;64:1437-60 pubmed publisher
    ..GPR17 is mediated by the interaction of a type I PDZ-binding motif located at the C-terminus of the receptor and SNX27, a recently identified protein of the endosome-associated retromer complex and whose functions in oligodendrocytes ..
  37. Pim D, Broniarczyk J, Bergant M, Playford M, Banks L. A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking. J Virol. 2015;89:10145-55 pubmed publisher
    ..Here we show an interaction between papillomavirus L2 proteins and the related PX-FERM family member sorting nexin 27 (SNX27), which is mediated in part by a novel interaction between the PDZ domain of SNX27 and sequences in a ..
  38. Teasdale R, Loci D, Houghton F, Karlsson L, Gleeson P. A large family of endosome-localized proteins related to sorting nexin 1. Biochem J. 2001;358:7-16 pubmed
    ..On the basis of these results, the functions of these SNX molecules are likely to be unique to endosomes, mediated in part by interactions with SNX-specific C-terminal sequences and membrane-associated determinants. ..
  39. Balana B, Bahima L, Bodhinathan K, Taura J, Taylor N, Nettleton M, et al. Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. PLoS ONE. 2013;8:e59800 pubmed publisher
    ..Thus, the presence of a functional RA domain and the interaction with Ras-like G proteins comprise a novel mechanism for modulating SNX27b control of GIRK channel surface expression and cellular excitability. ..
  40. Ghai R, Tello Lafoz M, Norwood S, Yang Z, Clairfeuille T, Teasdale R, et al. Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. J Cell Sci. 2015;128:553-65 pubmed
    b>Sorting nexin 27 (SNX27) controls the endosomal-to-cell-surface recycling of diverse transmembrane protein cargos...
  41. Rincón E, Sáez de Guinoa J, Gharbi S, Sorzano C, Carrasco Y, Merida I. Translocation dynamics of sorting nexin 27 in activated T cells. J Cell Sci. 2011;124:776-88 pubmed publisher
    b>Sorting nexin 27 (SNX27) belongs to the sorting nexin family of proteins, which participate in vesicular and protein trafficking...
  42. Arnaud C, Sebbagh M, Nola S, Audebert S, Bidaut G, Hermant A, et al. MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. FEBS Lett. 2009;583:2326-32 pubmed publisher
    ..Altogether, these results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2. ..
  43. Rabouille C. Retriever fetches integrins from endosomes. Nat Cell Biol. 2017;19:1144-1146 pubmed publisher
    Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for...
  44. Tello Lafoz M, Rodriguez Rodriguez C, Kinna G, Loo L, Hong W, Collins B, et al. SNX27 links DGK? to the control of transcriptional and metabolic programs in T lymphocytes. Sci Rep. 2017;7:16361 pubmed publisher
    b>Sorting nexin 27 (SNX27) recycles PSD-95, Dlg1, ZO-1 (PDZ) domain-interacting membrane proteins and is essential to sustain adequate brain functions...
  45. Clairfeuille T, Mas C, Chan A, Yang Z, Tello Lafoz M, Chandra M, et al. A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. Nat Struct Mol Biol. 2016;23:921-932 pubmed publisher
    ..b>Sorting nexin 27 (SNX27) cooperates with the retromer complex in the recycling of proteins containing type I PSD95-Dlg-ZO1 (..
  46. McGough I, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom K, et al. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. J Cell Sci. 2014;127:4940-53 pubmed publisher
    ..Overall, these data reveal hidden complexities in retromer-mediated sorting and open up new directions in our molecular understanding of this essential sorting complex. ..
  47. Gallon M, Clairfeuille T, Steinberg F, Mas C, Ghai R, Sessions R, et al. A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proc Natl Acad Sci U S A. 2014;111:E3604-13 pubmed publisher
    The sorting nexin 27 (SNX27)-retromer complex is a major regulator of endosome-to-plasma membrane recycling of transmembrane cargos that contain a PSD95, Dlg1, zo-1 (PDZ)-binding motif...
  48. Kvainickas A, Orgaz A, Nägele H, Diedrich B, Heesom K, Dengjel J, et al. Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50. J Cell Sci. 2017;130:382-395 pubmed publisher
    ..Here, we firmly establish ANKRD50 as a new and essential component of the SNX27-retromer-WASH super complex...
  49. Sun L, Hu X, Chen W, He W, Zhang Z, Wang T. Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling. Biosci Rep. 2016;36:e00296 pubmed publisher
    b>SNX27 is the only sorting nexin (SNX) that contains a PDZ domain, which interacts with PDZ-binding motif of target proteins to regulate the trafficking of these proteins...
  50. Williams R, Schlüter T, Roberts M, Knauth P, Bohnensack R, Cutler D. Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. Mol Biol Cell. 2004;15:3095-105 pubmed
    ..First, it promotes the endocytosis of P-selectin from the plasma membrane. Second, it inhibits the movement of P-selectin into lysosomes, thereby reducing its degradation. ..
  51. MacNeil A, Pohajdak B. Polarization of endosomal SNX27 in migrating and tumor-engaged natural killer cells. Biochem Biophys Res Commun. 2007;361:146-50 pubmed
    ..Using an in vitro conjugation approach, we show that in NK-92 cells, endosomal Sorting Nexin 27 (SNX27) polarizes to the IS during tumor cell engagement in a distinct compartment adjacent to the cytotoxic ..
  52. Sarker R, Cha B, Kovbasnjuk O, Cole R, Gabelli S, Tse C, et al. Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes. Mol Biol Cell. 2017;28:1754-1767 pubmed publisher
    ..bind throughout the NHE3 intracellular C-terminus, including calcineurin homologous protein, the NHERF family and SNX27 (related PDZ domains)...
  53. Tello Lafoz M, Martínez Martínez G, Rodríguez Rodríguez C, Albar J, Huse M, Gharbi S, et al. Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. Traffic. 2017;18:491-504 pubmed publisher
    ..b>Sorting nexin 27 (SNX27) controls the endosomal traffic of PSD95, Dlg1, ZO-1 (PDZ) domain-interacting proteins, and its ..
  54. Tian X, Irannejad R, Bowman S, Du Y, Puthenveedu M, von Zastrow M, et al. The ?-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ?2-Adrenergic Receptor. J Biol Chem. 2016;291:14510-25 pubmed publisher
    ..Although ARRDC3 has no effect on ?2AR endocytosis or degradation, it negatively regulates ?2AR entry into SNX27-occupied endosomal tubules...
  55. Wang X, Huang T, Zhao Y, Zheng Q, Thompson R, Bu G, et al. Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity. Cell Rep. 2014;9:1023-33 pubmed publisher
    ..of a chromosome 21-encoded microRNA-155 results in decreased levels of the membrane trafficking component, SNX27, diminishing glutamate receptor recycling and thereby impairing synaptic functions in DS...