Gene Symbol: SNX2
Description: sorting nexin 2
Alias: TRG-9, sorting nexin-2, CTB-36H16.2, transformation-related gene 9 protein
Species: human
Products:     SNX2

Top Publications

  1. Teasdale R, Loci D, Houghton F, Karlsson L, Gleeson P. A large family of endosome-localized proteins related to sorting nexin 1. Biochem J. 2001;358:7-16 pubmed
    ..Searches of human expressed sequence tag databases with SNX1 revealed eleven related human cDNA sequences, termed SNX2 to SNX12, eight of them novel...
  2. Rojas R, Kametaka S, Haft C, Bonifacino J. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol. 2007;27:1112-24 pubmed
    ..There is conflicting evidence, however, as to whether a homologous sorting nexin, SNX2, is truly a component of the retromer...
  3. Bonifacino J, Hurley J. Retromer. Curr Opin Cell Biol. 2008;20:427-36 pubmed publisher
    ..The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35...
  4. Gullapalli A, Garrett T, Paing M, Griffin C, Yang Y, Trejo J. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004;15:2143-55 pubmed
    Sorting nexin 1 (SNX1) and SNX2, homologues of the yeast vacuolar protein-sorting (Vps)5p, contain a phospholipid-binding motif termed the phox homology (PX) domain and a carboxyl terminal coiled-coil region...
  5. Carlton J, Bujny M, Peter B, Oorschot V, Rutherford A, Arkell R, et al. Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci. 2005;118:4527-39 pubmed
  6. Itai N, Shimazu T, Kimura T, Ibe I, Yamashita R, Kaburagi Y, et al. The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis. PLoS ONE. 2018;13:e0207205 pubmed publisher
    ..Since SNX5 forms heterodimers with SNX1 or SNX2, we examined the effect of phosphorylation at S226 on the heterodimer formations...
  7. Matczak P, Wojtulewski S. Performance of Møller-Plesset second-order perturbation theory and density functional theory in predicting the interaction between stannylenes and aromatic molecules. J Mol Model. 2015;21:41 pubmed publisher
    ..The complexes between SnX2 (where X = H, F, Cl, Br, and I) and benzene or pyridine are considered...
  8. Gullapalli A, Wolfe B, Griffin C, Magnuson T, Trejo J. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006;17:1228-38 pubmed
    Sorting nexin 1 (SNX1) and SNX2 are the mammalian homologues of the yeast Vps5p retromer component that functions in endosome-to-Golgi trafficking...
  9. Zhang A, He X, Zhang L, Yang L, Woodman P, Li W. Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into. J Biol Chem. 2014;289:29180-94 pubmed publisher
    ..BLOS1 interacted with SNX2 (a retromer subunit) and TSG101 (an endosomal sorting complex required for transport subunit-I) to mediate EGFR ..

More Information


  1. Li X, Zuo X, Jiang X, Li D, Cui B, Liu D. Enhanced photocatalysis for water splitting in layered tin chalcogenides with high carrier mobility. Phys Chem Chem Phys. 2019;: pubmed publisher
    ..40 eV and 2.34 eV), newly fabricated tin monochalcogenides (SnX, X = S, Se) and dichalcogenides SnX2, whose monolayer formation energies are much smaller than MoS2, are promising materials for harvesting visible ..
  2. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..that Wls recycling is mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6...
  3. Sun R, Liu Y, Lu M, Ding Q, Wang P, Zhang H, et al. ALIX increases protein content and protective function of iPSC-derived exosomes. J Mol Med (Berl). 2019;: pubmed publisher
    ..b>SNX2 was important for ALIX-mediated exosomal function...
  4. Sun B, Ma Z, He C, Wu K. Anisotropic thermoelectric properties of layered compounds in SnX2 (X = S, Se): a promising thermoelectric material. Phys Chem Chem Phys. 2015;17:29844-53 pubmed publisher
    ..94 × 10(19) (SnSe2) vs. 2.87 × 10(19) cm(-3) (SnS2). The best ZT values in SnX2 (X = S, Se) are comparable to that in Bi2Te3 (0.8), a typical thermoelectric material...
  5. Duclos C, Champagne A, Carrier J, Saucier C, Lavoie C, Denault J. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017;3:16100 pubmed publisher
    ..Here we show that in apoptosis, sorting nexin 1 and 2 (SNX1 and SNX2), two proteins involved in endosomal sorting, are cleaved by initiator caspases and also by executioner caspase-6 ..
  6. Matczak P. Theoretical insight into the interaction between SnX2 (X?=?H, F, Cl, Br, I) and benzene. J Mol Model. 2016;22:208 pubmed publisher
    For a series of five model complexes composed of a singlet SnX2 molecule (X?=?H, F, Cl, Br, I) and a benzene molecule, the first-principles calculations of their energetics and the analysis of their electron density topology have been ..
  7. Cui Y, Xie S, Luan J, Zhou X, Han J. Identification of the receptor tyrosine kinases (RTKs)-oriented functional targets of miR-206 by an antibody-based protein array. FEBS Lett. 2015;589:2131-5 pubmed publisher
    ..Within this network, we analyzed two validated targets, PAX3 and SNX2, and one candidate target, EIF4E, may account for the inhibitory effect of miR-206 on MET phosphorylation...
  8. Norris A, Tammineni P, Wang S, Gerdes J, Murr A, Kwan K, et al. SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Proc Natl Acad Sci U S A. 2017;114:E307-E316 pubmed publisher
    ..ESCRT-0 and SNX-1/RME-8 microdomains was also compromised in the absence of RME-8 and SNX-1, a phenomenon we observed to be conserved, as depletion of Snx1 and Snx2 in HeLa cells also led to greater overlap of Rme-8 and Hrs on endosomes.
  9. Dong R, Saheki Y, Swarup S, Lucast L, Harper J, De Camilli P. Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. Cell. 2016;166:408-423 pubmed publisher
    ..VAP is recruited to retromer budding sites on endosomes via an interaction with the retromer SNX2 subunit. Cells lacking VAP accumulate high levels of PI4P, actin comets, and trans-Golgi proteins on endosomes...
  10. Ghesquieres H, Slager S, Jardin F, Veron A, Asmann Y, Maurer M, et al. Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy. J Clin Oncol. 2015;33:3930-7 pubmed publisher
    ..In a meta-analysis of the four studies, the top loci for EFS were marked by rs7712513 at 5q23.2 (near SNX2 and SNCAIP; HR, 1.39; 95% CI, 1.23 to 1.57; P = 2...
  11. Hierro A, Rojas A, Rojas R, Murthy N, Effantin G, Kajava A, et al. Functional architecture of the retromer cargo-recognition complex. Nature. 2007;449:1063-7 pubmed
    ..cargo recognition VPS26-VPS29-VPS35 heterotrimer and a membrane-targeting heterodimer or homodimer of SNX1 and/or SNX2 (ref. 13)...
  12. Schaaf C, Benzing J, Schmitt T, Erz D, Tewes M, Bartram C, et al. Novel interaction partners of the TPR/MET tyrosine kinase. FASEB J. 2005;19:267-9 pubmed
    ..we were able to identify several novel, putative intracellular TPR/MET-substrates: SNAPIN, DCOHM, VAV-1, Sorting nexin 2, Death associated protein kinase 3, SMC-1, Centromeric protein C, and hTID-1...
  13. Skånland S, Walchli S, Utskarpen A, Wandinger Ness A, Sandvig K. Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. Traffic. 2007;8:297-309 pubmed
    ..Knockdown of SNX2 or SNX4 inhibits ricin transport to the Golgi apparatus to the same extent as when hVps34 is perturbed...
  14. Kvainickas A, Jimenez Orgaz A, Nägele H, Hu Z, Dengjel J, Steinberg F. Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. J Cell Biol. 2017;216:3677-3693 pubmed publisher
    ..In this study, we demonstrate that heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to ..
  15. Prosser D, Tran D, Schooley A, Wendland B, Ngsee J. A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Traffic. 2010;11:1347-62 pubmed publisher
    The sorting nexins SNX1 and SNX2 are members of the retromer complex involved in protein sorting within the endocytic pathway...
  16. Zhong Q, Watson M, Lazar C, Hounslow A, Waltho J, Gill G. Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell. 2005;16:2049-57 pubmed
    ..Thus, the obligate dimerization of SNX1 that is driven by the C-terminal domain creates a high-affinity PI binding species that properly targets the holo protein to endosomes. ..
  17. Ogi S, Fujita H, Kashihara M, Yamamoto C, Sonoda K, Okamoto I, et al. Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs. Cancer Sci. 2013;104:573-83 pubmed publisher
    ..SNX1 and SNX2 are components of the mammalian retromer complex and they also play critical roles in the membrane trafficking of ..
  18. Lieu Z, Gleeson P. Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin. Eur J Cell Biol. 2010;89:379-93 pubmed publisher
    ..retromer, however, whereas sorting nexin 1 (SNX1) is specifically required for transport of Shiga toxin, sorting nexin 2 (SNX2) is required for the transport of TGN38...
  19. Kanzawa M, Hara S, Semba S, Yokozaki H, Hirokawa M, Itoh T. Sorting Nexin 2 (SNX2): a potential marker of active thyrocytes in normal and hyperfunctioning thyroid disorders. Appl Immunohistochem Mol Morphol. 2014;22:302-7 pubmed publisher
    ..In this study, we demonstrated that SNX2 is expressed in columnar and active thyroid follicular cells but not in flattened inactive thyrocytes...
  20. Ernst T, Score J, Deininger M, Hidalgo Curtis C, Lackie P, Ershler W, et al. Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia. Br J Haematol. 2011;153:43-6 pubmed publisher
    ..Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9)...
  21. Fuchs U, Rehkamp G, Haas O, Slany R, Konig M, Bojesen S, et al. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc Natl Acad Sci U S A. 2001;98:8756-61 pubmed
    ..We screened a human kidney library and identified a sorting nexin, SNX2, as a protein interaction partner of FBP17...
  22. Simonetti B, Danson C, Heesom K, Cullen P. Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. J Cell Biol. 2017;216:3695-3712 pubmed publisher
    ..The retromer-linked SNX-BAR proteins comprise heterodimeric combinations of SNX1 or SNX2 with SNX5 or SNX6 and serve to regulate the biogenesis of tubular endosomal sorting profiles...
  23. Wurthner J, Frank D, Felici A, Green H, Cao Z, Schneider M, et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem. 2001;276:19495-502 pubmed
  24. Haft C, de la Luz Sierra M, Barr V, Haft D, Taylor S. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol. 1998;18:7278-87 pubmed
    ..and deduced the amino acid sequences of three novel homologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4). In addition, we identified a presumed splice variant isoform of SNX1 (SNX1A)...
  25. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
    ..retromers whose membrane-bound subcomplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6...
  26. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases. ..
  27. Haft C, de la Luz Sierra M, Bafford R, Lesniak M, Barr V, Taylor S. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell. 2000;11:4105-16 pubmed
    Sorting nexin (SNX) 1 and SNX2 are mammalian orthologs of Vps5p, a yeast protein that is a subunit of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi ..
  28. Hong Z, Yang Y, Zhang C, Niu Y, Li K, Zhao X, et al. The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Cell Res. 2009;19:1334-49 pubmed publisher
    ..These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates. ..
  29. Abdul Ghani M, Hartman K, Ngsee J. Abstrakt interacts with and regulates the expression of sorting nexin-2. J Cell Physiol. 2005;204:210-8 pubmed
    ..Sorting Nexin-2 (SNX2) is involved in protein sorting in the trans-Golgi network, endosome, and/or lysosome compartments, with loss of ..
  30. Trousdale C, Kim K. Retromer: Structure, function, and roles in mammalian disease. Eur J Cell Biol. 2015;94:513-21 pubmed publisher
    ..Despite the current understanding of the retromer complex, there are still many questions to be answered in regards to its overall role in cell homeostasis. ..
  31. Fuchs U, Rehkamp G, Slany R, Follo M, Borkhardt A. The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. FEBS Lett. 2003;554:10-6 pubmed
    ..We demonstrate that FBP17 binds via a special TNKS-binding motif to tankyrase. The physiological relevance is indicated by co-immunoprecipitation of endogenous proteins in 293T cells. ..