SNX1

Summary

Gene Symbol: SNX1
Description: sorting nexin 1
Alias: HsT17379, VPS5, sorting nexin-1, sorting nexin 1A
Species: human
Products:     SNX1

Top Publications

  1. van Weering J, Verkade P, Cullen P. SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation. Traffic. 2012;13:94-107 pubmed publisher
    ..Here, using well-defined Rab GTPases as endosomal compartment markers, we have analyzed the localization of SNX1 [endosome-to-trans-Golgi network (TGN) transport as part of the SNX-BAR-retromer complex], SNX4 (cargo-recycling ..
  2. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
    ..mammalian retromers whose membrane-bound subcomplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6...
  3. Haft C, de la Luz Sierra M, Barr V, Haft D, Taylor S. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol. 1998;18:7278-87 pubmed
    b>Sorting nexin 1 (SNX1) is a protein that binds to the epidermal growth factor (EGF) receptor and is proposed to play a role in directing EGF receptors to lysosomes for degradation (R. C. Kurten, D. L. Cadena, and G. N...
  4. Mari M, Bujny M, Zeuschner D, Geerts W, Griffith J, Petersen C, et al. SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic. 2008;9:380-93 pubmed
    ..In endosomes, sortilin and MPRs concentrated in sorting nexin 1 (SNX1)-positive buds and vesicles...
  5. Liu H, Liu Z, Chen C, Magill S, Jiang Y, Liu Y. Inhibitory regulation of EGF receptor degradation by sorting nexin 5. Biochem Biophys Res Commun. 2006;342:537-46 pubmed
    ..Here, we report the identification of a novel interaction between two members of the family, SNX1 and SNX5, which is mediated by the newly defined BAR domain of both SNXs...
  6. Carlton J, Bujny M, Peter B, Oorschot V, Rutherford A, Mellor H, et al. Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol. 2004;14:1791-800 pubmed
    ..The prototypical SNX is sorting nexin-1 (SNX1), a protein that through its PX domain binds phosphatidylinositol 3-monophosphate [PtdIns(3)P] and ..
  7. Rojas R, Kametaka S, Haft C, Bonifacino J. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol. 2007;27:1112-24 pubmed
    ..showed that the mammalian retromer comprises three proteins, named Vps26, Vps29, and Vps35, plus the sorting nexin, SNX1. There is conflicting evidence, however, as to whether a homologous sorting nexin, SNX2, is truly a component of ..
  8. Cozier G, Carlton J, McGregor A, Gleeson P, Teasdale R, Mellor H, et al. The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J Biol Chem. 2002;277:48730-6 pubmed
    ..It has been reported that the PX domain of sorting nexin 1 (SNX1) specifically binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) (Zhong, Q., Lazar, C...
  9. Itai N, Shimazu T, Kimura T, Ibe I, Yamashita R, Kaburagi Y, et al. The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis. PLoS ONE. 2018;13:e0207205 pubmed publisher
    ..Since SNX5 forms heterodimers with SNX1 or SNX2, we examined the effect of phosphorylation at S226 on the heterodimer formations...

More Information

Publications73

  1. Day T, Kallakury B, Ross J, Voronel O, Vaidya S, Sheehan C, et al. Dual Targeting of EGFR and IGF1R in the TNFAIP8 Knockdown Non-small Cell Lung Cancer Cells. Mol Cancer Res. 2019;: pubmed publisher
    ..TNFAIP8 knockdown cells showed decreased level of EGFR and increased expression of sorting nexin 1 (SNX1), a key regulator of the EGFR trafficking through the endosomal compartments, and treatment with SNX1 ..
  2. Ribas L, Crespo B, Sánchez Baizán N, Xavier D, Kuhl H, Rodriguez J, et al. Characterization of the European Sea Bass (Dicentrarchus labrax) Gonadal Transcriptome During Sexual Development. Mar Biotechnol (NY). 2019;: pubmed publisher
    ..We found that hsd17β10 is a reliable marker of early ovarian differentiation. Further, three genes, pdgfb, snx1, and nfy, not previously related to fish sex differentiation, were tightly associated with testis development in ..
  3. McGovern S, Purfield D, Ring S, Carthy T, Graham D, Berry D. Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans. J Dairy Sci. 2019;102:4249-4263 pubmed publisher
    ..associations were with the 10 functional candidate genes KALRN, ZBTB20, LPP, SLA2, FI3A1, LRCH3, DNAJC6, ZDHHC14, SNX1, and HAS2...
  4. Kovtun O, Leneva N, Bykov Y, Ariotti N, Teasdale R, Schaffer M, et al. Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature. 2018;561:561-564 pubmed publisher
    ..assembled on membrane tubules with the bin/amphiphysin/rvs-domain-containing sorting nexin protein Vps5, using cryo-electron tomography and subtomogram averaging...
  5. Sharma R, Gulia R, Bhattacharyya S. A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors. J Neurosci. 2018;38:8605-8620 pubmed publisher
    ..b>Sorting nexin 1 (SNX1) has been shown to regulate the endosomal sorting of few cell surface receptors either to lysosomes ..
  6. Freeman C, Hesketh G, Seaman M. RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. J Cell Sci. 2014;127:2053-70 pubmed publisher
    ..Tubules are formed by a dimer of sorting nexins, a key component of which is SNX1. Cargo selection is mediated by the VPS35-VPS29-VPS26 trimer, which additionally recruits the WASH complex through ..
  7. Kedziora K, Jalink K. Fluorescence resonance energy transfer microscopy (FRET). Methods Mol Biol. 2015;1251:67-82 pubmed publisher
    ..We illustrate this approach with an example of studying the interaction of nexin (SNX1) proteins...
  8. Qin J, Teng J, Zhu Z, Chen J, Wu Y. Glargine Promotes Human Colorectal Cancer Cell Proliferation via Upregulation of miR-95. Horm Metab Res. 2015;47:861-5 pubmed publisher
    ..The expression of microRNA-95 (miR-95) and sorting nexin 1 (SNX1) protein was also determined by real-time PCR and Western blotting, respectively...
  9. Ruan Y, Wasteneys G. CLASP: a microtubule-based integrator of the hormone-mediated transitions from cell division to elongation. Curr Opin Plant Biol. 2014;22:149-158 pubmed publisher
    ..CLASP modulates levels of the auxin efflux carrier PIN2 by tethering SNX1 endosomes to cortical microtubules, which in turn fine tunes auxin maxima in the root apical meristem...
  10. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..report that Wls recycling is mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6...
  11. Koliwer J, Park M, Bauch C, von Zastrow M, Kreienkamp H. The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization. J Biol Chem. 2015;290:6120-9 pubmed publisher
    ..Here PIST colocalizes with SNX1 and the internalized β1AR and protects endocytosed receptors from lysosomal degradation...
  12. Yong X, Hu W, Zhou X, Wang J, Burstein E, Jia D. Expression and purification of the SNX1/SNX6 complex. Protein Expr Purif. 2018;151:93-98 pubmed publisher
    ..The SNX members SNX1/2 and SNX5/6 form dimers, and mediate endosome-to-trans Golgi network (TGN) transport through coordinating cargo ..
  13. Gaba R, Groth J, Parvinian A, Guzman G, Casadaban L. Gene expression in hepatocellular carcinoma: pilot study of potential transarterial chemoembolization response biomarkers. J Vasc Interv Radiol. 2015;26:723-32 pubmed publisher
    ..49-3.50 fold) pretreatment chemotherapy-sensitivity and mitosis (ATF4, BAX, CCNE1, KIF11, NFX1, PPP3CA, SNX1, TOP2A, and TOP2B) gene mRNA expression compared with tumors with PR, in addition to lower CXCL10 levels (0...
  14. Zhang J, Zhang C, Hu L, He Y, Shi Z, Tang S, et al. Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer. Cancer Invest. 2015;33:165-71 pubmed publisher
    ..The anti-miRNAs significantly reduced miR-21 and miR-95 levels, increased PTEN, SNX1, and SGPP1 protein expression, but reduced Akt Ser(473) and Thr(308) phosphorylation...
  15. Hirano T, Sato M. Overexpression of FAB1A-GFP recruits SNX2b on the endosome membrane in snx1-1 mutant in Arabidopsis. Plant Signal Behav. 2016;11:e1110663 pubmed publisher
    ..endosomes and a loss-of FAB1 function causes the release of late endosomal effector proteins, ARA7/RABF2b and SORTING NEXIN 1 from the endosome membrane, indicating that FAB1 or its product PtdIns(3,5)P2 mediates the maturation process ..
  16. Duclos C, Champagne A, Carrier J, Saucier C, Lavoie C, Denault J. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017;3:16100 pubmed publisher
    ..Here we show that in apoptosis, sorting nexin 1 and 2 (SNX1 and SNX2), two proteins involved in endosomal sorting, are cleaved by initiator caspases and also ..
  17. Welin A, Weber S, Hilbi H. Quantitative Imaging Flow Cytometry of Legionella-Infected Dictyostelium Amoebae Reveals the Impact of Retrograde Trafficking on Pathogen Vacuole Composition. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..markers, such as calnexin, the small GTPase Rab1 (but not Rab7 and Rab8), and retrograde trafficking components (Vps5, Vps26, Vps35)...
  18. Ma M, Burd C, Chi R. Distinct complexes of yeast Snx4 family SNX-BARs mediate retrograde trafficking of Snc1 and Atg27. Traffic. 2017;18:134-144 pubmed publisher
    ..Live cell imaging of individual endosomes shows that Snx4 and the Vps5-Vps17 retromer SNX-BAR heterodimer operate concurrently on a maturing endosome...
  19. Salanenka Y, Verstraeten I, Löfke C, Tabata K, Naramoto S, Glanc M, et al. Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane. Proc Natl Acad Sci U S A. 2018;115:3716-3721 pubmed publisher
    ..This GA effect requires components of the retromer complex, such as Sorting Nexin 1 (SNX1) and its interacting, microtubule (MT)-associated protein, the Cytoplasmic Linker-Associated Protein (..
  20. Hirano T, Munnik T, Sato M. Phosphatidylinositol 3-Phosphate 5-Kinase, FAB1/PIKfyve Kinase Mediates Endosome Maturation to Establish Endosome-Cortical Microtubule Interaction in Arabidopsis. Plant Physiol. 2015;169:1961-74 pubmed publisher
    ..We found that FAB1 predominantly localizes on the Sorting Nexin1 (SNX1)-residing late endosomes, and a loss of FAB1 function causes the release of late endosomal proteins, Ara7, and SNX1 ..
  21. Xhabija B, Vacratsis P. Receptor-mediated Endocytosis 8 Utilizes an N-terminal Phosphoinositide-binding Motif to Regulate Endosomal Clathrin Dynamics. J Biol Chem. 2015;290:21676-89 pubmed publisher
    ..Interestingly, RME-8 endosomal association is also regulated by the PI(3)P-binding protein SNX1, a member of the retromer complex...
  22. Song P, Trajkovic K, Tsunemi T, Krainc D. Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway. J Neurosci. 2016;36:2425-37 pubmed publisher
    ..led to decreased endosomal tubulation and membrane association of vesicle protein sorting 35 (VPS35) and sorting nexin 1 (SNX1), as well as decreased mannose 6 phosphate receptor (M6PR), suggesting the impairment of retromer ..
  23. Norris A, Tammineni P, Wang S, Gerdes J, Murr A, Kwan K, et al. SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Proc Natl Acad Sci U S A. 2017;114:E307-E316 pubmed publisher
    ..ESCRT-0 and SNX-1/RME-8 microdomains was also compromised in the absence of RME-8 and SNX-1, a phenomenon we observed to be conserved, as depletion of Snx1 and Snx2 in HeLa cells also led to greater overlap of Rme-8 and Hrs on endosomes.
  24. Buenaventura T, Kanda N, Douzenis P, Jones B, Bloom S, Chabosseau P, et al. A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells. Diabetes. 2018;67:385-399 pubmed publisher
    ..We identify five (clathrin, dynamin1, AP2, sorting nexins [SNX] SNX27, and SNX1) that increase and four (huntingtin-interacting protein 1 [HIP1], HIP14, GASP-1, and Nedd4) that decrease insulin ..
  25. Wang Y, Zhou Y, Szabo K, Haft C, Trejo J. Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. Mol Biol Cell. 2002;13:1965-76 pubmed
    ..PAR1 is internalized, sorted to lysosomes, and degraded, we investigated whether PAR1 interacted with sorting nexin 1 (SNX1)...
  26. Chen X, Chen S, Hang W, Huang H, Ma H. MiR-95 induces proliferation and chemo- or radioresistance through directly targeting sorting nexin1 (SNX1) in non-small cell lung cancer. Biomed Pharmacother. 2014;68:589-95 pubmed publisher
    ..with normal cells) and tumor tissues (compared with corresponding normal tissues), whereas the protein level of SNX1 was downregulated in NSCLC cell lines...
  27. Nishimura Y, Takiguchi S, Ito S, Itoh K. EGF‑stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib‑resistant human lung cancer cell line. Int J Oncol. 2015;46:1721-9 pubmed publisher
    ..endosomes to the late endosomes occurs in the gefitinib-resistant NSCLC cells, in which large amounts of sorting nexin 1 (SNX1) are colocalized with EGFR in the aggregated early endosomes where the internalized pEGFR is also ..
  28. Kurten R, Cadena D, Gill G. Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science. 1996;272:1008-10 pubmed
    ..A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) ..
  29. Zhong Q, Lazar C, Tronchère H, Sato T, Meerloo T, Yeo M, et al. Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A. 2002;99:6767-72 pubmed
    ..The first member of this family, SNX1, was identified via interaction with the epidermal growth factor receptor...
  30. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..Human SNX1, -2, and -4 have been proposed to play a role in receptor trafficking and have been shown to bind to several ..
  31. Trousdale C, Kim K. Retromer: Structure, function, and roles in mammalian disease. Eur J Cell Biol. 2015;94:513-21 pubmed publisher
    ..These five proteins (Vps5, Vps17, Vps26, Vps29, and Vps35 in yeast and SNX1/2, SNX5/6, Vps26, Vps29, and Vps35 in mammalian cells) act as a ..
  32. Haft C, de la Luz Sierra M, Bafford R, Lesniak M, Barr V, Taylor S. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell. 2000;11:4105-16 pubmed
    ..a model in which hVps35 serves as the core of a multimeric complex by binding directly to hVps26, hVps29, and SNX1. Deletional analyses of hVps35 demonstrate that amino acid residues 1-53 and 307-796 of hVps35 bind to the coiled ..
  33. Wurthner J, Frank D, Felici A, Green H, Cao Z, Schneider M, et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem. 2001;276:19495-502 pubmed
  34. Bujny M, Ewels P, Humphrey S, Attar N, Jepson M, Cullen P. Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection. J Cell Sci. 2008;121:2027-36 pubmed publisher
    ..Here, we establish that at early stages of Salmonella infection, sorting nexin-1 (SNX1) - a host phosphoinositide-binding protein that normally associates with early endosomes and regulates transport to ..
  35. Simonetti B, Danson C, Heesom K, Cullen P. Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. J Cell Biol. 2017;216:3695-3712 pubmed publisher
    ..The retromer-linked SNX-BAR proteins comprise heterodimeric combinations of SNX1 or SNX2 with SNX5 or SNX6 and serve to regulate the biogenesis of tubular endosomal sorting profiles...
  36. Bryant D, Kerr M, Hammond L, Joseph S, Mostov K, Teasdale R, et al. EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J Cell Sci. 2007;120:1818-28 pubmed
    ..of the E-cadherin-catenin complex into endosomal compartments that colocalized with EEA1 and the sorting nexin, SNX1. Depletion of cellular SNX1 levels by siRNA resulted in increased intracellular accumulation and turnover of E-..
  37. Harbour M, Breusegem S, Antrobus R, Freeman C, Reid E, Seaman M. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010;123:3703-17 pubmed publisher
  38. Pons V, Hullin Matsuda F, Nauze M, Barbaras R, Peres C, Collet X, et al. Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor. J Biol Chem. 2003;278:21155-61 pubmed
    ..We identified sorting nexin 1 (SNX1) as a novel partner of Ent-1 and confirmed the specificity of interaction by co-immunoprecipitation ..
  39. Zhong Q, Watson M, Lazar C, Hounslow A, Waltho J, Gill G. Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell. 2005;16:2049-57 pubmed
    ..b>SNX1 is located on endosomes, but its low affinity PX domain fails to localize in vivo...
  40. Niu Y, Zhang C, Sun Z, Hong Z, Li K, Sun D, et al. PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. Nat Cell Biol. 2013;15:417-29 pubmed publisher
    ..These results establish organelle-specific phosphoinositide regulation of motor-cargo interaction as a mechanism for cargo release by molecular motors at target membrane. ..
  41. Nishimura Y, Takiguchi S, Yoshioka K, Nakabeppu Y, Itoh K. Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines. Int J Oncol. 2012;41:1520-30 pubmed publisher
    ..and A549 showed internalized pEGFR accumulation in the aggregated early endosomes, and this was associated with SNX1, a protein that interacts with and enhances the degradation of EGFR upon EGF stimulation...
  42. Kurten R, Eddington A, Chowdhury P, Smith R, Davidson A, Shank B. Self-assembly and binding of a sorting nexin to sorting endosomes. J Cell Sci. 2001;114:1743-56 pubmed
    ..We report that a sorting nexin SNX1, a candidate endosomal retention protein, self-assembles in vitro and in vivo, and has this property in common with ..
  43. van Weering J, Sessions R, Traer C, Kloer D, Bhatia V, Stamou D, et al. Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J. 2012;31:4466-80 pubmed publisher
    ..8 Å structure of a SNX1-BAR domain homodimer, establish that dimerization is achieved in part through neutralization of charged residues in ..
  44. Nguyen L, Holdren M, Nguyen A, Furuya M, Bianchini M, Levy E, et al. Sorting nexin 1 down-regulation promotes colon tumorigenesis. Clin Cancer Res. 2006;12:6952-9 pubmed
    ..analyses were done on human colon cancer tissue specimens to determine the levels of one endocytic protein, sorting nexin 1 (SNX1)...
  45. Mamo A, Jules F, Dumaresq Doiron K, Costantino S, Lefrancois S. The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting. Mol Cell Biol. 2012;32:1855-66 pubmed publisher
    ..Taken together, our results support a role for CLN5 in controlling the itinerary of the lysosomal sorting receptors by regulating retromer recruitment at the endosome. ..
  46. Pons V, Ustunel C, Rolland C, Torti E, Parton R, Gruenberg J. SNX12 role in endosome membrane transport. PLoS ONE. 2012;7:e38949 pubmed publisher
    ..Altogether, our data show that despite lower expression level, SNX12 shares redundant functions with SNX3 in the biogenesis of multivesicular endosomes. ..
  47. Wisniewski B, Sharma J, Legan E, Paulson E, Merrill S, Manogaran A. Toxicity and infectivity: insights from de novo prion formation. Curr Genet. 2018;64:117-123 pubmed publisher
    ..work shows that toxicity is associated with prion formation and this toxicity is exacerbated by deletion of the VPS5 gene...
  48. Gullapalli A, Wolfe B, Griffin C, Magnuson T, Trejo J. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006;17:1228-38 pubmed
    b>Sorting nexin 1 (SNX1) and SNX2 are the mammalian homologues of the yeast Vps5p retromer component that functions in endosome-to-Golgi trafficking...
  49. Huang Z, Huang S, Wang Q, Liang L, Ni S, Wang L, et al. MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma. Cancer Res. 2011;71:2582-9 pubmed publisher
    ..revealed that miR-95 repressed the expression of reporter gene coupled to the 3'-untranslated region of sorting nexin 1 (SNX1), whereas miR-95 silencing up-regulated SNX1 expression...
  50. Popoff V, Mardones G, Bai S, Chambon V, Tenza D, Burgos P, et al. Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes. Traffic. 2009;10:1868-80 pubmed publisher
    ..Here, we show that the curvature recognition subunit component sorting nexin 1 (SNX1) of retromer interacts with receptor-mediated endocytosis-8 (RME-8) protein, and that RME-8 and SNX1 ..
  51. Hong Z, Yang Y, Zhang C, Niu Y, Li K, Zhao X, et al. The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Cell Res. 2009;19:1334-49 pubmed publisher
    ..Previous studies identified SNX1/2 as one of the components of the SNX subcomplex, and SNX5/6 as candidates for the second SNX...
  52. Villar V, Jones J, Armando I, Asico L, Escano C, Lee H, et al. Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem. 2013;288:152-63 pubmed publisher
    ..The dopamine D5 receptor (D(5)R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor retrieval from the trans-Golgi network...
  53. Abubakar Y, Zheng W, Olsson S, Zhou J. Updated Insight into the Physiological and Pathological Roles of the Retromer Complex. Int J Mol Sci. 2017;18: pubmed publisher
    ..of a conserved trimer of the cargo selective complex (CSC), Vps26-Vps35-Vps29 and a dimer of sorting nexins (SNXs), Vps5-Vps17...
  54. Bian Z, Feng Y, Xue Y, Hu Y, Wang Q, Zhou L, et al. Down-regulation of SNX1 predicts poor prognosis and contributes to drug resistance in colorectal cancer. Tumour Biol. 2016;37:6619-25 pubmed publisher
    As a potential tumor suppressor, the detailed clinical application value of sorting nexin 1 (SNX1) has not been elucidated in colorectal cancer (CRC)...
  55. Vardarajan B, Bruesegem S, Harbour M, Inzelberg R, FRIEDLAND R, St George Hyslop P, et al. Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging. 2012;33:2231.e15-2231.e30 pubmed publisher
    ..We obtained significant evidence of association with KIAA1033 (VEGAS p = 0.025), SNX1 (VEGAS p = 0.035), SNX3 (p = 0.0057), and RAB7A (VEGAS p = 0.018)...
  56. Simpson F, Martin S, Evans T, Kerr M, James D, Parton R, et al. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic. 2005;6:442-58 pubmed
    ..We propose that HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains. ..
  57. Leparc G, Mitra R. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. Nucleic Acids Res. 2007;35:3192-202 pubmed
    ..Overall, PASE was able to uncover 59 novel alternative cassette exons in C. elegans and humans through a genome-wide ab initio prediction method that enriches for exons involved in signaling. ..
  58. Shank B, Wiley H, Kurten R. Structural and functional characterization of the human gene for sorting nexin 1 (SNX1). DNA Cell Biol. 2001;20:287-96 pubmed
    The aim of the present study was to identify the gene for sorting nexin 1 (SNX1) to evaluate the potential for tissue-specific alternative splicing and to analyze the activity of the SNX1 promoter...
  59. Brumbarova T, Ivanov R. SNX1-mediated protein recycling: Piecing together the tissue-specific regulation of arabidopsis iron acquisition. Plant Signal Behav. 2018;13:e1411451 pubmed publisher
    ..The Arabidopsis SNX1 protein is involved in recycling the iron transporter IRT1, thus promoting its presence at the plasma membrane...
  60. Prosser D, Tran D, Schooley A, Wendland B, Ngsee J. A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Traffic. 2010;11:1347-62 pubmed publisher
    The sorting nexins SNX1 and SNX2 are members of the retromer complex involved in protein sorting within the endocytic pathway...
  61. Nisar S, Kelly E, Cullen P, Mundell S. Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent. Traffic. 2010;11:508-19 pubmed publisher
    ..However, little is known about the molecular mechanisms underlying P2Y receptor traffic. Sorting nexin 1 (SNX1) has been shown to regulate the endosomal sorting of cell surface receptors either to lysosomes where ..
  62. Wang J, Kerr M, Karunaratne S, Jeanes A, Yap A, Teasdale R. The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. PLoS ONE. 2010;5:e13763 pubmed publisher
    ..b>SNX1 (40.9+/-3.19 macropinosomes), SNX5 (36.99+/-4.48 macropinosomes), SNX9 (37.55+/-2.4 macropinosomes), SNX18 (88...
  63. Kvainickas A, Jimenez Orgaz A, Nägele H, Hu Z, Dengjel J, Steinberg F. Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. J Cell Biol. 2017;216:3677-3693 pubmed publisher
    ..In this study, we demonstrate that heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde transport of CI-MPR from ..
  64. Chin L, Raynor M, Wei X, Chen H, Li L. Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J Biol Chem. 2001;276:7069-78 pubmed
    ..Here, we report that Hrs interacts with sorting nexin 1 (SNX1), a recently identified mammalian homologue of yeast Vps5p that recognizes the lysosomal targeting code ..