SNW1

Summary

Gene Symbol: SNW1
Description: SNW domain containing 1
Alias: Bx42, FUN20, NCOA-62, PRPF45, Prp45, SKIIP, SKIP, SKIP1, SNW domain-containing protein 1, SKI interacting protein, homolog of Drosophila BX42, nuclear protein SkiP, nuclear receptor coactivator NCoA-62, nuclear receptor coactivator, 62-kD, ski-interacting protein
Species: human
Products:     SNW1

Top Publications

  1. Chen Y, Zhang L, Jones K. SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing. Genes Dev. 2011;25:701-16 pubmed publisher
    The Ski-interacting protein SKIP/SNW1 functions as both a splicing factor and a transcriptional coactivator for induced genes...
  2. Zhou S, Fujimuro M, Hsieh J, Chen L, Miyamoto A, Weinmaster G, et al. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol. 2000;20:2400-10 pubmed
    ..We have examined the mechanism whereby NotchIC overcomes CBF1-mediated transcriptional repression. We identified SKIP (Ski-interacting protein) as a CBF1 binding protein in a yeast two-hybrid screen...
  3. Brès V, Yoshida T, Pickle L, Jones K. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. Mol Cell. 2009;36:75-87 pubmed publisher
    The Ski-interacting protein SKIP/SNW1 associates with the P-TEFb/CDK9 elongation factor and coactivates inducible genes, including HIV-1...
  4. Xu C, Zhang J, Huang X, Sun J, Xu Y, Tang Y, et al. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. J Biol Chem. 2006;281:15900-8 pubmed
    ..It is recruited by SKIP, another essential component of 45 S activated spliceosome, into spliceosome just before the catalytic step 1...
  5. Barry J, Leong G, Church W, Issa L, Eisman J, Gardiner E. Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues. J Biol Chem. 2003;278:8224-8 pubmed
    ..The p160 coactivator GRIP1 and the distinct coregulator Ski-interacting protein (SKIP)/NCoA-62 synergistically enhance ligand-dependent VDR transcriptional activity...
  6. Abankwa D, Millard S, Martel N, Choong C, Yang M, Butler L, et al. Ski-interacting protein (SKIP) interacts with androgen receptor in the nucleus and modulates androgen-dependent transcription. BMC Biochem. 2013;14:10 pubmed publisher
    ..Ski-interacting protein (SKIP; SNW1, NCOA62) is a cofactor shown to interact with several NRs and a diverse range of other transcription factors...
  7. Wang X, Zhang S, Zhang J, Huang X, Xu C, Wang W, et al. A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR. J Biol Chem. 2010;285:4951-63 pubmed publisher
    ..Recent mass spectrometric analyses have shown that Ski interaction protein (SKIP) and peptidylprolyl isomerase-like protein 1 (PPIL1) are Prp19-related factors that constitute the spliceosome B, B*..
  8. Zhang C, Baudino T, Dowd D, Tokumaru H, Wang W, MacDonald P. Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. J Biol Chem. 2001;276:40614-20 pubmed
    ..In contrast, NCoA-62/Ski-interacting protein (SKIP) is a distinct, activation function-2-independent coactivator for VDR...
  9. Figueroa J, Hayman M. The human Ski-interacting protein functionally substitutes for the yeast PRP45 gene. Biochem Biophys Res Commun. 2004;319:1105-9 pubmed
    The PRP45 gene has been identified as encoding a protein involved in mRNA splicing that is essential in Saccharomyces cerevisiae...

More Information

Publications63

  1. Zhang C, Dowd D, Staal A, Gu C, Lian J, Van Wijnen A, et al. Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem. 2003;278:35325-36 pubmed
    Nuclear coactivator-62 kDa/Ski-interacting protein (NCoA62/SKIP) is a putative vitamin D receptor (VDR) and nuclear receptor coactivator protein that is unrelated to other VDR coactivators such as those in the steroid receptor coactivator ..
  2. Baudino T, Kraichely D, Jefcoat S, Winchester S, Partridge N, MacDonald P. Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription. J Biol Chem. 1998;273:16434-41 pubmed
    ..One cDNA clone designated NCoA-62, encoded a 62, 000-Da protein that is highly related to BX42, a Drosophila melanogaster nuclear protein involved in ecdysone-stimulated gene expression...
  3. Ohlson M, Huang Z, Alto N, Blanc M, Dixon J, Chai J, et al. Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Cell Host Microbe. 2008;4:434-46 pubmed publisher
    ..is essential for inducing tubulation of the Salmonella phagosome and binds the mammalian kinesin-binding protein SKIP. Coexpression of SifA with the effector SseJ induced tubulation of mammalian cell endosomes, similar to that ..
  4. Brès V, Gomes N, Pickle L, Jones K. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev. 2005;19:1211-26 pubmed
    ..Here we show that the splicing-associated c-Ski-interacting protein, SKIP, is required for Tat transactivation in vivo and stimulates HIV-1 transcription elongation, but not initiation, in ..
  5. Leong G, Subramaniam N, Issa L, Barry J, Kino T, Driggers P, et al. Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. Biochem Biophys Res Commun. 2004;315:1070-6 pubmed
    Ski-interacting protein (SKIP), a vitamin D receptor (VDR) coactivator, also functions as a repressor in Notch signalling in association with the corepressor SMRT...
  6. Rosa Ferreira C, Munro S. Arl8 and SKIP act together to link lysosomes to kinesin-1. Dev Cell. 2011;21:1171-8 pubmed publisher
    ..By using affinity chromatography, we find that Arl8-GTP binds to the soluble protein SKIP (SifA and kinesin-interacting protein, aka PLEKHM2)...
  7. Leong G, Subramaniam N, Figueroa J, Flanagan J, Hayman M, Eisman J, et al. Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription. J Biol Chem. 2001;276:18243-8 pubmed
    ..Ski-interacting protein (SKIP), a nuclear hormone receptor coactivator, was examined as a possible modulator of transcriptional regulation of the ..
  8. Dahl R, Wani B, Hayman M. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. Oncogene. 1998;16:1579-86 pubmed
    ..Using v-Ski sequence as bait, the human gene skip (Ski Interacting Protein) was identified as encoding a protein which interacts with both the cellular and viral forms of Ski in ..
  9. Scott K, Plon S. CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. Gene. 2005;359:119-26 pubmed
    ..two-hybrid screening approach, we find that this portion of CHES1 interacts with Ski-interacting protein (SKIP; NCoA-62), which is a transcriptional co-regulator known to associate with repressor complexes...
  10. Edwards D, Wardell S, Boonyaratanakornkit V. Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. J Steroid Biochem Mol Biol. 2002;83:173-86 pubmed
    ..This interaction mediates rapid progesterone activation of Src/MAP K signaling pathways and defines a molecular mechanism for some of the rapid non-genomic actions of progesterone. ..
  11. Laduron S, Deplus R, Zhou S, Kholmanskikh O, Godelaine D, De Smet C, et al. MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription. Nucleic Acids Res. 2004;32:4340-50 pubmed
    ..Using yeast two-hybrid screening, we detected an interaction between MAGE-A1 and Ski Interacting Protein (SKIP)...
  12. Kang M, Lee S, Um E, Kang H, Hwang E, Kim E, et al. Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells. Nucleic Acids Res. 2010;38:822-31 pubmed publisher
    ..Here, we show that SIRT1 associates with SKI-interacting protein (SKIP) and modulates its activity as a coactivator of retinoic acid receptor (RAR)...
  13. Carbonell C, Ulsamer A, Vivori C, Papasaikas P, Böttcher R, Joaquin M, et al. Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK. Cell Rep. 2019;27:847-859.e6 pubmed publisher
    ..Splicing network analysis revealed a functional connection between p38 and the spliceosome component SKIIP, whose depletion abolished a significant fraction of p38-mediated AS changes...
  14. Lackner D, Durocher D, Karlseder J. A siRNA-based screen for genes involved in chromosome end protection. PLoS ONE. 2011;6:e21407 pubmed publisher
    ..We also identified a weak TIF phenotype for SKIIP (SNW1), a splicing factor and transcriptional co-activator...
  15. Hálová M, Gahura O, Prevorovský M, Cit Z, Novotny M, Valentová A, et al. Nineteen complex-related factor Prp45 is required for the early stages of cotranscriptional spliceosome assembly. RNA. 2017;23:1512-1524 pubmed publisher
    ..Here, we examine the effect of nineteen complex-related splicing factor Prp45 (a homolog of SNW1/SKIP) on cotranscriptional splicing...
  16. Verma S, De Jesus P, Chanda S, Verma I. SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway. Mol Cell Biol. 2019;39: pubmed publisher
    ..The top hit was SNW1, a splicing factor and transcriptional coactivator...
  17. Lee S, Park H, Yoon D, Kim B, Ahn J, Luan S, et al. Rice cyclophilin OsCYP18-2 is translocated to the nucleus by an interaction with SKIP and enhances drought tolerance in rice and Arabidopsis. Plant Cell Environ. 2015;38:2071-87 pubmed publisher
    ..Although PPiL1 is known to interact with ski-interacting protein (SKIP), a transcriptional co-regulator and spliceosomal component, there have been no functional analyses of PPiL1 ..
  18. Gironella M, Malicet C, Cano C, Sandi M, Hamidi T, Tauil R, et al. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. J Cell Physiol. 2009;221:594-602 pubmed publisher
    ..MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8, induces chromatin remodeling and relaxation allowing access to DNA of the repair machinery. ..
  19. Liu G, Huang X, Cui X, Zhang J, Wei L, Ni R, et al. High SKIP expression is correlated with poor prognosis and cell proliferation of hepatocellular carcinoma. Med Oncol. 2013;30:537 pubmed publisher
    Ski-interacting protein (SKIP) is a transcriptional cofactor distinct from other cofactors and involved in the regulation of many cancer-related proteins...
  20. Hu L, Wu C, Zhao X, Heist R, Su L, Zhao Y, et al. Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Clin Cancer Res. 2012;18:5507-14 pubmed publisher
    ..3) were associated with better NSCLC survival. In addition, rs7629386 at 3p22.1 (CTNNB1) and rs3850370 at 14q24.3 (SNW1-ALKBH1-NRXN3) were further replicated in the Caucasian population...
  21. Llères D, Denegri M, Biggiogera M, Ajuh P, Lamond A. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. EMBO Rep. 2010;11:445-51 pubmed publisher
    ..hnRNP-M affects both 5' and 3' alternative splice site choices, and an hnRNP-M mutant lacking the CDC5L/PLRG1 interaction domain is unable to modulate alternative splicing of an adeno-E1A mini-gene substrate. ..
  22. Ishida M, Ohbayashi N, Fukuda M. Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Sci Rep. 2015;5:8238 pubmed publisher
    ..Here we discovered that small GTPase Rab1A on melanosomes recruits SKIP/PLEKHM2 as a Rab1A-specific effector and that Rab1A, SKIP, and a kinesin-1/(Kif5b+KLC2) motor form a transport ..
  23. Dellago H, Löscher M, Ajuh P, Ryder U, Kaisermayer C, Grillari Voglauer R, et al. Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing. Biochem J. 2011;438:81-91 pubmed publisher
    ..These results suggest a novel and unexpected role of Exo70 in nuclear mRNA splicing, where it might signal membrane events to the splicing apparatus. ..
  24. Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, et al. Enhancement of TGF-?-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP). Biochem Biophys Res Commun. 2017;490:1045-1051 pubmed publisher
    ..Here, we found that c-Abl phosphorylates SKI-interacting protein (SKIP), a nuclear cofactor of the transcription factor Smad3...
  25. Turkçu G, Alabalık U, Keles A, Ibiloğlu I, Kucukoner M, Sen H, et al. Comparison of SKIP expression in malignant pleural mesotheliomas with Ki-67 proliferation index and prognostic parameters. Pol J Pathol. 2016;67:108-13 pubmed
    We aimed to determine the presence of SKI-interacting protein (SKIP) expression in malignant pleural mesothelioma (MPM) and its effect on prognosis by investigating SKIP correlation with the Ki-67 proliferation index and prognostic ..
  26. Stegmann C, Luhrmann R, Wahl M. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE. 2010;5:e10013 pubmed publisher
    ..The peptidyl-prolyl cis/trans isomerase PPIL1 is a component of the human spliceosome and binds to the spliceosomal SKIP protein via a binding site distinct from its active site...
  27. Petersen H, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek A, et al. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci. 2003;116:453-61 pubmed
    ..MegBP-interacting partners included several transcriptional regulators such as the SKI-interacting protein (SKIP), a co-activator of the vitamin D receptor...
  28. Mbonye U, Karn J. Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. Virology. 2014;454-455:328-39 pubmed publisher
    ..An in-depth comprehensive understanding of the molecular control of HIV-1 transcription should inform the development of optimal combinatorial reactivation strategies that are intended to purge the latent viral reservoir...
  29. McKenzie J, Riento K, Ridley A. Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin. FEBS Lett. 2006;580:2388-94 pubmed
    ..These data identify CKI epsilon as a novel occludin kinase that may be important for the regulation of occludin. ..
  30. Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U. The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity. Mech Dev. 2001;104:3-20 pubmed
    ..We find that Notch 3 IC, like Notch 1 IC, can bind the SKIP and PCAF proteins...
  31. Tolde O, Folk P. Stress-induced expression of p53 target genes is insensitive to SNW1/SKIP downregulation. Cell Mol Biol Lett. 2011;16:373-84 pubmed publisher
    ..Here, we have downregulated SNW1/SKIP, a splicing factor and a transcriptional co-regulator, which was found to interact with P-TEFb and synergistically ..
  32. Tang J, Chang H, Yang X. The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62. FEBS Lett. 2005;579:2883-90 pubmed
    ..The role of Daxx in transcription is not well understood. Here, we show that Daxx interacts with Skip/NcoA62, a transcription cofactor that modulates the activity of oncoproteins including Ski and NotchIC...
  33. Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, et al. Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Int J Biochem Cell Biol. 2005;37:2273-83 pubmed
    ..It showed that human LNX interacted with Ski interacting protein (SKIP) via PDZ domains...
  34. Bondy Chorney E, Baldwin R, Didillon A, Chabot B, Jasmin B, Côté J. RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells. Int J Biochem Cell Biol. 2017;91:124-135 pubmed publisher
    ..Amongst the top hits were SNW Domain containing 1 (SNW1) and RBP-associated with lethal yellow mutation (RALY), which both associated with the PRMT1 pre-mRNA and upon ..
  35. Rice A. The HIV-1 Tat team gets bigger. Cell Host Microbe. 2010;7:179-81 pubmed publisher
    ..Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function. ..
  36. Cui Z, Tong A, Huo Y, Yan Z, Yang W, Yang X, et al. SKIP controls flowering time via the alternative splicing of SEF pre-mRNA in Arabidopsis. BMC Biol. 2017;15:80 pubmed publisher
    ..Ski-interacting protein (SKIP), a splicing factor, is essential for circadian clock function and abiotic stress tolerance; however, the ..
  37. Negeri D, Eggert H, Gienapp R, Saumweber H. Inducible RNA interference uncovers the Drosophila protein Bx42 as an essential nuclear cofactor involved in Notch signal transduction. Mech Dev. 2002;117:151-62 pubmed
    ..By induced RNAi we demonstrate that the conserved nuclear protein Bx42 is essential for the development of many tissues...
  38. Bosse Y, Lemire M, Poon A, Daley D, He J, Sandford A, et al. Asthma and genes encoding components of the vitamin D pathway. Respir Res. 2009;10:98 pubmed publisher
    ..CYP24A1, GC) and six that are known to be transcriptionally regulated by vitamin D (IL10, IL1RL1, CD28, CD86, IL8, SKIIP)...
  39. Kim Y, Noguchi S, Hayashi Y, Tsukahara T, Shimizu T, Arahata K. The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. Hum Mol Genet. 2001;10:1129-39 pubmed
    ..Furthermore, Ski-interacting protein (SKIP) was isolated as a binding protein for PABP2 using the yeast two-hybrid system...
  40. Schneider C, Agafonov D, Schmitzová J, Hartmuth K, Fabrizio P, Luhrmann R. Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes. PLoS Genet. 2015;11:e1005539 pubmed publisher
    ..Upon step 1 catalysis, Cwc25 contacts with the branch-site region, and enhanced crosslinks of Prp8 and Prp45 with nucleotides surrounding the branch-site were observed...
  41. van der Lelij P, Stocsits R, Ladurner R, Petzold G, Kreidl E, Koch B, et al. SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs. EMBO J. 2014;33:2643-58 pubmed publisher
    ..The molecular cause of this defect is unknown. Here, we show that the spliceosome subunits SNW1 and PRPF8 are essential for sister chromatid cohesion in human cells...
  42. Katsogiannou M, Andrieu C, Baylot V, Baudot A, Dusetti N, Gayet O, et al. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Mol Cell Proteomics. 2014;13:3585-601 pubmed publisher
    ..Validation of Hsp27 involvement in both processes in human prostate cancer cells supports our system biology-predicted functions and provides new insights into Hsp27 roles in cancer cells. ..
  43. Zhou S, Hayward S. Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol Cell Biol. 2001;21:6222-32 pubmed
    ..In yeast two-hybrid assays, the SMRT aa 1291 to 1495 domain interacted with SKIP and SMRT aa 1291 to 1495 colocalized with SKIP within the nuclei of cotransfected cells...
  44. Moreno D, Viana R, Sanz P. Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase. Int J Biochem Cell Biol. 2009;41:2431-9 pubmed publisher
    ..Our results indicate that AMPK is able to interact physically with this subunit and modify its phosphorylation status, supporting a possible role for AMPK in regulating proteasome function. ..
  45. Prathapam T, Kühne C, Banks L. Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. Nucleic Acids Res. 2002;30:5261-8 pubmed
    b>Ski interacting protein (Skip) plays an important role in the transforming activity of both v-Ski and EBNA2 (Epstein-Barr virus encoded latency protein) and is involved in EBNA2 and NotchIC activation of CBF1-repressed promoters...
  46. Liu X, Ni Q, Xu J, Sheng C, Wang Q, Chen J, et al. Expression and prognostic role of SKIP in human breast carcinoma. J Mol Histol. 2014;45:169-80 pubmed publisher
    Ski-interacting protein (SKIP) is a nuclear hormone receptor-interacting cofactor, interactions with the proto-oncogene Ski, appears to modulate a number of signalling pathways involved in control of cell proliferation and differentiation,..
  47. Zhou S, Fujimuro M, Hsieh J, Chen L, Hayward S. A role for SKIP in EBNA2 activation of CBF1-repressed promoters. J Virol. 2000;74:1939-47 pubmed
    ..A yeast two-hybrid screen performed using CBF1 as the bait identified a protein, SKIP, which had not previously been recognized as a CBF1-associated protein...
  48. Zhao J, Wang Y, Mu C, Xu Y, Sang J. MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells. Oncogene. 2017;36:5023-5034 pubmed publisher
    ..These newly discovered MAGEA1-NICD1 and MAGEA1-FBXW7 interactions have potential clinical implications in breast and ovarian cancer treatment. ..
  49. Villar V, Kocic J, Bugarski D, Jovcic G, Santibanez J. SKIP is required for TGF-?1-induced epithelial mesenchymal transition and migration in transformed keratinocytes. FEBS Lett. 2010;584:4586-92 pubmed publisher
    ..Although Sky-interacting protein (SKIP) regulates TGF-?1-induced Smad activation, its role in the induction of cell malignance remains uncertain...
  50. Wardell S, Boonyaratanakornkit V, Adelman J, Aronheim A, Edwards D. Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. Mol Cell Biol. 2002;22:5451-66 pubmed
    ..JDP-2 has preferential activity on PR among the nuclear receptors tested and is expressed in progesterone target cells and tissues, suggesting that it has a physiological role in PR function. ..
  51. Bracken C, Wall S, Barré B, Panov K, Ajuh P, Perkins N. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res. 2008;68:7621-8 pubmed publisher
    ..we show that the majority of nucleoplasmic SNIP1 is present within a previously undescribed complex containing SkIP, THRAP3, BCLAF1, and Pinin, all proteins with reported roles in RNA processing and transcriptional regulation...
  52. Sato N, Maeda M, Sugiyama M, Ito S, Hyodo T, Masuda A, et al. Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells. Cancer Med. 2015;4:268-77 pubmed publisher
    ..The SKIP region of SNW1 interacted with the N-terminus of EFTUD2 as well as two independent regions in the C-terminus of ..
  53. Fryer C, White J, Jones K. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell. 2004;16:509-20 pubmed
    ..Here we show that CycC:CDK8 and CycT1:CDK9/P-TEFb are recruited with Notch and associated coactivators (MAM, SKIP) to the HES1 promoter in signaling cells...
  54. Prathapam T, Kuhne C, Hayman M, Banks L. Ski interacts with the evolutionarily conserved SNW domain of Skip. Nucleic Acids Res. 2001;29:3469-76 pubmed
    b>Ski interacting protein (Skip) has been found to bind to the highly conserved region of Ski, which is required for its transforming activity...