SNAPIN

Summary

Gene Symbol: SNAPIN
Description: SNAP associated protein
Alias: BLOC1S7, BLOS7, BORCS3, SNAPAP, SNARE-associated protein Snapin, BLOC-1 subunit 7, SNAP-25-binding protein, SNARE associated protein snapin, biogenesis of lysosomal organelles complex-1, subunit 7, biogenesis of lysosome-related organelles complex 1 subunit 7, synaptosomal-associated protein 25-binding protein
Species: human
Products:     SNAPIN

Top Publications

  1. Talbot K, Cho D, Ong W, Benson M, Han L, Kazi H, et al. Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin. Hum Mol Genet. 2006;15:3041-54 pubmed
    ..We demonstrate here that snapin is a binding partner of dysbindin-1 in vitro and in the brain...
  2. Wolff S, Stöter M, Giamas G, Piesche M, Henne Bruns D, Banting G, et al. Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett. 2006;580:6477-84 pubmed
    In this study we identified snapin as an interaction partner of the CK1 isoform delta (CK1delta) in the yeast two-hybrid system and localized the interacting domains of both proteins...
  3. Mistry A, Mallick R, Klein J, Weimbs T, Sands J, Fröhlich O. Syntaxin specificity of aquaporins in the inner medullary collecting duct. Am J Physiol Renal Physiol. 2009;297:F292-300 pubmed publisher
    ..However, the trafficking mechanisms that recruit AQP2 to the plasma membrane are still unclear. Snapin is emerging as an important mediator in the initial interaction of trafficked proteins with target soluble N-..
  4. Mistry A, Mallick R, Fröhlich O, Klein J, Rehm A, Chen G, et al. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. J Biol Chem. 2007;282:30097-106 pubmed
    ..screen of a human kidney cDNA library with the UT-A1 intracellular loop (residues 409-594) as bait, we identified snapin, a ubiquitously expressed SNARE-associated protein, as a novel UT-A1 binding partner...
  5. Chheda M, Ashery U, Thakur P, Rettig J, Sheng Z. Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nat Cell Biol. 2001;3:331-8 pubmed
    ..Here we identify Snapin, a protein of relative molecular mass 15,000 that is implicated in neurotransmission by binding to SNAP-25, as a ..
  6. Rüder C, Reimer T, Delgado Martinez I, Hermosilla R, Engelsberg A, Nehring R, et al. EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin. Mol Biol Cell. 2005;16:1245-57 pubmed
    ..Here, we demonstrate that EBAG9 interacts with Snapin, which is likely to be a modulator of Synaptotagmin-associated regulated exocytosis...
  7. Suzuki F, Morishima S, Tanaka T, Muramatsu I. Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6. J Biol Chem. 2007;282:29563-73 pubmed
    ..We identified Snapin as a protein interacting with the C terminus of the alpha(1A)-AR...
  8. Ilardi J, Mochida S, Sheng Z. Snapin: a SNARE-associated protein implicated in synaptic transmission. Nat Neurosci. 1999;2:119-24 pubmed
    ..We have now identified another SNAP-25-binding protein, called Snapin. Snapin was enriched in neurons and exclusively located on synaptic vesicle membranes...
  9. Pan P, Tian J, Sheng Z. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron. 2009;61:412-24 pubmed publisher
    ..Using cortical neurons from snapin-deficient mice, we reveal a role for Snapin in facilitating synchronous release...

More Information

Publications55

  1. Araujo C, Quintero I, Ovaska K, Herrala A, Hautaniemi S, Vihko P. Transmembrane prostatic acid phosphatase (TMPAP) delays cells in G1 phase of the cell cycle. Prostate. 2016;76:151-62 pubmed publisher
    ..We previously identified a novel transmembrane prostatic acid phosphatase (TMPAP) isoform, which interacts with snapin. TMPAP is expressed on the plasma membrane, as well as endosomal/lysosomal and exosomal membrane vesicles by means ..
  2. Ye X, Feng T, Tammineni P, Chang Q, Jeong Y, Margolis D, et al. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease. J Neurosci. 2017;37:2639-2655 pubmed publisher
    ..Here, we reveal that dynein-Snapin-mediated retrograde transport regulates BACE1 trafficking in axons and APP processing at presynaptic terminals...
  3. Di Giovanni J, Sheng Z. Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting. EMBO J. 2015;34:2059-77 pubmed publisher
    ..sorting stations, which raises a fundamental question: are SVs sorted toward endolysosomal pathways? Here, we used snapin mutants as tools to assess how endolysosomal sorting and trafficking impact presynaptic activity in wild-type and ..
  4. Hayes M, Bryon K, Satkurunathan J, Levine T. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Traffic. 2011;12:260-8 pubmed publisher
    ..cerevisiae: Blos1, snapin and cappuccino (cno)...
  5. Zhou B, Zhu Y, Lin L, Cai Q, Sheng Z. Snapin deficiency is associated with developmental defects of the central nervous system. Biosci Rep. 2011;31:151-8 pubmed publisher
    ..We recently revealed that Snapin plays a critical role in co-ordinating dynein-driven retrograde transport and late endosomal-lysosomal trafficking,..
  6. Cheng X, Zhou B, Lin M, Cai Q, Sheng Z. Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes. J Cell Biol. 2015;209:377-86 pubmed publisher
    ..In this paper, we demonstrate that late endosome (LE)-loaded dynein-snapin complexes drive AV retrograde transport in axons upon fusion of autophagosomes with LEs into amphisomes...
  7. Han M, Hu Z, Chen C, Chen Y, Gucek M, Li Z, et al. Dysbindin-associated proteome in the p2 synaptosome fraction of mouse brain. J Proteome Res. 2014;13:4567-80 pubmed publisher
    ..The interactions of several selected candidates, including WDR11, FAM91A1, snapin, muted, pallidin, and two proteasome subunits, PSMD9 and PSMA4, were verified by coimmunoprecipitation...
  8. Ye X, Cai Q. Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons. Cell Rep. 2014;6:24-31 pubmed publisher
    ..Here, using snapin-deficient mice combined with gene rescue experiments, we reveal that Snapin, as a dynein motor adaptor for late ..
  9. Xie Y, Zhou B, Lin M, Wang S, Foust K, Sheng Z. Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice. Neuron. 2015;87:355-70 pubmed publisher
    ..Expressing dynein-adaptor snapin reverses transport defects by competing with hSOD1(G93A) for binding dynein, thus rescuing autophagy-lysosomal ..
  10. Somanath S, Partridge C, Marshall C, Rowe T, Turner M. Snapin mediates insulin secretory granule docking, but not trans-SNARE complex formation. Biochem Biophys Res Commun. 2016;473:403-7 pubmed publisher
    ..Here we demonstrate that in pancreatic β-cells the SNAP-25 accessory protein, snapin, C-terminal H2 domain binds SNAP-25 through its N-terminal Sn-1 domain...
  11. Tammineni P, Ye X, Feng T, Aikal D, Cai Q. Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons. elife. 2017;6: pubmed publisher
    ..This interaction impairs dynein recruitment to amphisomes through competitive interruption of dynein-Snapin motor-adaptor coupling, thus immobilizing them in distal axons...
  12. Hicks J, Yoo D, Liu H. Interaction of porcine reproductive and respiratory syndrome virus major envelope proteins GP5 and M with the cellular protein Snapin. Virus Res. 2018;249:85-92 pubmed publisher
    ..Subsequently, the interactions between PRRSV GP5/M and the cellular protein Snapin were mapped using truncated versions of the GP5 and M proteins in a yeast two-hybrid assay to localize the ..
  13. Lu L, Cai Q, Tian J, Sheng Z. Snapin associates with late endocytic compartments and interacts with late endosomal SNAREs. Biosci Rep. 2009;29:261-9 pubmed publisher
    ..Our previous studies showed that Snapin, as a SNAP25 (25 kDa synaptosome-associated protein)-binding protein, plays a critical role in priming synaptic ..
  14. Zhou B, Cai Q, Xie Y, Sheng Z. Snapin recruits dynein to BDNF-TrkB signaling endosomes for retrograde axonal transport and is essential for dendrite growth of cortical neurons. Cell Rep. 2012;2:42-51 pubmed publisher
    ..In particular, mechanisms recruiting dynein to TrkB signaling endosomes have not been elucidated. Here, using snapin deficient mice and gene rescue experiments combined with compartmentalized cultures of live cortical neurons, we ..
  15. Shen A, Lei J, Yang E, Pei Y, Chen Y, Gong H, et al. Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin. J Virol. 2011;85:11732-41 pubmed publisher
    ..In this study, we provide the first direct evidence that UL70 specifically interacts with Snapin, a human protein that is predominantly localized in the cytoplasm and is associated with cellular vesicles...
  16. Niwa S, Tao L, Lu S, Liew G, Feng W, Nachury M, et al. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Curr Biol. 2017;27:2569-2578.e4 pubmed publisher
    ..We found mutations in six BORC subunits-blos-1/BLOS1, blos-2/BLOS2, snpn-1/Snapin, sam-4/Myrlysin, blos-7/Lyspersin, and blos-9/MEF2BNB-cause defects in axonal transport of SVPs, leading to ..
  17. Li W, Zhang Q, Oiso N, Novak E, Gautam R, O Brien E, et al. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet. 2003;35:84-9 pubmed
  18. Morenilla Palao C, Planells Cases R, García Sanz N, Ferrer Montiel A. Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J Biol Chem. 2004;279:25665-72 pubmed
    ..We report that two vesicular proteins, Snapin and synaptotagmin IX (Syt IX), strongly interact in vitro and in vivo with the TRPV1 N-terminal domain...
  19. Buxton P, Zhang X, Walsh B, Sriratana A, Schenberg I, Manickam E, et al. Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. Biochem J. 2003;375:433-40 pubmed
    ..One such factor, Snapin, has been reported to be a brain-specific protein that interacts with SNAP25, and regulates association of the ..
  20. Ciciotte S, Gwynn B, Moriyama K, Huizing M, Gahl W, Bonifacino J, et al. Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). Blood. 2003;101:4402-7 pubmed
  21. Shi B, Huang Q, Tak P, Vervoordeldonk M, Huang C, Dorfleutner A, et al. SNAPIN: an endogenous Toll-like receptor ligand in rheumatoid arthritis. Ann Rheum Dis. 2012;71:1411-7 pubmed publisher
    ..Interactions between TLRs and Snapin were demonstrated by reciprocal co-immunoprecipitation...
  22. Sun X, Yuan J, Jin T, Cheng X, Wang Q, Guo J, et al. Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes. Cell Signal. 2017;30:118-129 pubmed publisher
    ..By using the yeast two-hybrid system (Y2H), a Cav1.3-associated protein was screened, which was identified as Snapin. Physical interaction and co-localization between Snapin and Cav1...
  23. Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, et al. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab. 2005;2:373-84 pubmed
    ..Collectrin bound to SNARE complexes by interacting with snapin, a SNAP-25 binding protein, and facilitated SNARE complex formation...
  24. Böcker S, Heurich A, Franke C, Monajembashi S, Sachse K, Saluz H, et al. Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin. Int J Med Microbiol. 2014;304:542-53 pubmed publisher
    ..inclusion protein IncB as bait against a HeLa Yeast Two-hybrid (YTH) library revealed that the host protein Snapin interacts with IncB. Snapin is a cytoplasmic protein that plays a multivalent role in intracellular trafficking...
  25. Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino J. BORC, a multisubunit complex that regulates lysosome positioning. Dev Cell. 2015;33:176-88 pubmed publisher
    ..In turn, this causes reduced cell spreading and migration, highlighting the importance of BORC-dependent centrifugal transport for non-degradative functions of lysosomes. ..
  26. Song J, Li J, Liu H, Liu W, Feng Y, Zhou X, et al. Snapin interacts with G-protein coupled receptor PKR2. Biochem Biophys Res Commun. 2016;469:501-6 pubmed publisher
    ..we performed yeast two-hybrid screening by using PKR2 C-terminus (amino acids 333-384) as a bait, and identified Snapin as a novel interaction partner for PKR2...
  27. Navarro A, Encinar J, López Méndez B, Aguado Llera D, Prieto J, Gomez J, et al. Mutation of Ser-50 and Cys-66 in Snapin modulates protein structure and stability. Biochemistry. 2012;51:3470-84 pubmed publisher
    b>Snapin is a 15 kDa protein present in neuronal and non-neuronal cells that has been implicated in the regulation of exocytosis and endocytosis. Protein kinase A (PKA) phosphorylates Snapin at Ser-50, modulating its function...
  28. Wang G, Ren G, Cui X, Lu Z, Ma Y, Qi Y, et al. Host protein Snapin interacts with human cytomegalovirus pUL130 and affects viral DNA replication. J Biosci. 2016;41:173-82 pubmed
    ..In this study, HCMV UL130 protein was shown to directly interact with the human protein Snapin in human embryonic kidney HEK293 cells by Yeast two-hybrid screening, in vitro glutathione S-transferase (GST) ..
  29. Khatamzas E, Hipp M, Gaughan D, Pichulik T, Leslie A, Fernandes R, et al. Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling. EMBO J. 2017;36:2998-3011 pubmed publisher
    ..mediators of HIV-1 trans-infection of CD4+ T cells in DCs, including the dynein motor protein Snapin. Inhibition of Snapin enhanced localization of HIV-1 with TLR8+ early endosomes, triggered a pro-..
  30. Granata A, Watson R, Collinson L, Schiavo G, Warner T. The dystonia-associated protein torsinA modulates synaptic vesicle recycling. J Biol Chem. 2008;283:7568-79 pubmed publisher
    ..In this study, we found that snapin, which binds SNAP-25 (synaptosome-associated protein of 25,000 Da) and enhances the association of the SNARE ..
  31. Feng T, Tammineni P, Agrawal C, Jeong Y, Cai Q. Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation. J Biol Chem. 2017;292:1679-1690 pubmed publisher
    ..This phenotype can be reversed by Snapin-enhanced retrograde transport, which facilitates BACE1 trafficking to lysosomes for degradation...
  32. Yun H, Park J, Ho D, Kim H, Kim C, Oh H, et al. LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp Mol Med. 2013;45:e36 pubmed publisher
    ..Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts with LRRK2...
  33. Inagaki Y, Yasui K, Endo M, Nakajima T, Zen K, Tsuji K, et al. CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma. Cancer Genet Cytogenet. 2008;180:30-6 pubmed
    ..Among these, CREB3L4 (cAMP responsive element binding protein 3-like 4), INTS3 (integrator complex subunit 3), and SNAPAP (SNAP-associated protein) were significantly overexpressed in tumors from 18 HCC patients, compared with ..
  34. Moriyama K, Bonifacino J. Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. Traffic. 2002;3:666-77 pubmed
    ..These observations indicate that pallidin is a subunit of a novel multi-protein complex involved in the biogenesis of lysosome-related organelles. ..
  35. Ginter Matuszewska B, Spik A, Rembiszewska A, Koyias C, Kupryjanczyk J, Jaruzelska J. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. Mol Hum Reprod. 2009;15:173-9 pubmed publisher
    ..Here, we found that PUMILIO2 interacts also with SNAPIN, a modulator of SNARE complex assembly, which is involved in vesicle trafficking...
  36. Shi B, Huang Q, Birkett R, Doyle R, Dorfleutner A, Stehlik C, et al. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017;13:285-301 pubmed publisher
    We previously observed that SNAPIN, which is an adaptor protein in the SNARE core complex, was highly expressed in rheumatoid arthritis synovial tissue macrophages, but its role in macrophages and autoimmunity is unknown...
  37. Battle M, Maher V, McCormick J. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. Biochemistry. 2003;42:7270-82 pubmed
    ..Clearly, ST7 is an LRP, and therefore, it should now be referred to as LRP12. ..
  38. Schaaf C, Benzing J, Schmitt T, Erz D, Tewes M, Bartram C, et al. Novel interaction partners of the TPR/MET tyrosine kinase. FASEB J. 2005;19:267-9 pubmed
    ..a mouse embryo cDNA library, we were able to identify several novel, putative intracellular TPR/MET-substrates: SNAPIN, DCOHM, VAV-1, Sorting nexin 2, Death associated protein kinase 3, SMC-1, Centromeric protein C, and hTID-1...
  39. Lee H, Nemecek D, Schindler C, Smith W, Ghirlando R, Steven A, et al. Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2012;287:5882-90 pubmed publisher
    ..BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3...
  40. Starcevic M, Dell Angelica E. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2004;279:28393-401 pubmed
    ..Here, we report the identification of another four subunits of the complex. One is Snapin, a coiled-coil-forming protein previously characterized as a binding partner of synaptosomal-associated proteins ..
  41. Selvakumar D, Drescher M, Deckard N, Ramakrishnan N, Morley B, Drescher D. Dopamine D1A directly interacts with otoferlin synaptic pathway proteins: Ca2+ and phosphorylation underlie an NSF-to-AP2mu1 molecular switch. Biochem J. 2017;474:79-104 pubmed publisher
    ..D1A to soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE)-related proteins snapin, otoferlin, N-ethylmaleimide-sensitive factor (NSF), and adaptor-related protein complex 2, mu 1 (AP2mu1), ..
  42. Kim H, Zhong Q, Sheng Z, Yoshimori T, Liang C, Jung J. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci. 2012;125:4740-50 pubmed publisher
    ..endocytic trafficking pathway wherein Atg14L binds to and colocalizes with the fusogenic SNARE effector protein Snapin to facilitate endosome maturation...
  43. Zhang Q, Li Y, Zhang L, Yang N, Meng J, Zuo P, et al. E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex. Cell Mol Life Sci. 2013;70:153-65 pubmed publisher
    ..RNF13 directly interacted with snapin, a SNAP-25-interacting protein...
  44. Hunt R, Edris W, Chanda P, Nieuwenhuijsen B, Young K. Snapin interacts with the N-terminus of regulator of G protein signaling 7. Biochem Biophys Res Commun. 2003;303:594-9 pubmed
    ..From this analysis, we identified snapin, a protein associated with the SNARE complex in neurons, as an interactor with the N-terminus of RGS7...
  45. Song W, Seshadri M, Ashraf U, Mdluli T, Mondal P, Keil M, et al. Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab. 2011;13:308-19 pubmed publisher
    ..Here we show that these incretin-stimulated pathways converge at the level of snapin, and that PKA-dependent phosphorylation of snapin increases interaction among insulin secretory vesicle-associated ..
  46. Granata A, Koo S, Haucke V, Schiavo G, Warner T. CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. EMBO J. 2011;30:181-93 pubmed publisher
    ..TA binds CSN4 and the synaptic regulator snapin in neuroblastoma cells and in brain synaptosomes...