SNAP29

Summary

Gene Symbol: SNAP29
Description: synaptosome associated protein 29
Alias: CEDNIK, SNAP-29, synaptosomal-associated protein 29, soluble 29 kDa NSF attachment protein, synaptosomal-associated protein, 29kD, synaptosomal-associated protein, 29kDa, synaptosome associated protein 29kDa, vesicle-membrane fusion protein SNAP-29
Species: human
Products:     SNAP29

Top Publications

  1. Steegmaier M, Yang B, Yoo J, Huang B, Shen M, Yu S, et al. Three novel proteins of the syntaxin/SNAP-25 family. J Biol Chem. 1998;273:34171-9 pubmed
    ..SNAP-29 does not contain a predicted membrane anchor characteristic of other SNAREs. In vitro studies established that SNAP-29 is capable of binding to a broad range of syntaxins. ..
  2. Hohenstein A, Roche P. SNAP-29 is a promiscuous syntaxin-binding SNARE. Biochem Biophys Res Commun. 2001;285:167-71 pubmed
    ..These data suggest that SNAP-23 preferentially regulates plasma membrane-vesicle fusion events while SNAP-29 plays a role in the maintenance of various intracellular protein trafficking pathways. ..
  3. Su Q, Mochida S, Tian J, Mehta R, Sheng Z. SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission. Proc Natl Acad Sci U S A. 2001;98:14038-43 pubmed
  4. Rapaport D, Lugassy Y, Sprecher E, Horowitz M. Loss of SNAP29 impairs endocytic recycling and cell motility. PLoS ONE. 2010;5:e9759 pubmed publisher
    ..Membrane anchored SNAREs assemble into SNARE complexes that bring membranes together to promote fusion. SNAP29 is a ubiquitous synaptosomal-associated SNARE protein...
  5. Wong S, Xu Y, Zhang T, Griffiths G, Lowe S, Subramaniam V, et al. GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6. Mol Biol Cell. 1999;10:119-34 pubmed
    ..The coimmunoprecipitation of syntaxin 6 but not syntaxin 5 or GS28 from the Golgi extract by antibodies against GS32 further sustains the preferential interaction of GS32 with Golgi syntaxin 6. ..
  6. Pan P, Cai Q, Lin L, Lu P, Duan S, Sheng Z. SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons. J Biol Chem. 2005;280:25769-79 pubmed
    ..These findings suggest that SNAP-29 acts as a negative modulator for neurotransmitter release, probably by slowing recycling of the SNARE-based fusion machinery and synaptic vesicle turnover. ..
  7. Rotem Yehudar R, Galperin E, Horowitz M. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. J Biol Chem. 2001;276:33054-60 pubmed
    ..growth factor receptor (IGF-1R); they are EHD1, an Eps15 homology (EH) domain-containing protein 1, and SNAP29, a synaptosomal-associated protein...
  8. Fuchs Telem D, Stewart H, Rapaport D, Nousbeck J, Gat A, Gini M, et al. CEDNIK syndrome results from loss-of-function mutations in SNAP29. Br J Dermatol. 2011;164:610-6 pubmed publisher
    b>CEDNIK (cerebral dysgenesis, neuropathy, ichthyosis and keratoderma) syndrome is a rare genodermatosis which was shown 5 years ago in one family to be associated with a loss-of-function mutation in SNAP29, encoding a member of the SNARE ..
  9. Sprecher E, Ishida Yamamoto A, Mizrahi Koren M, Rapaport D, Goldsher D, Indelman M, et al. A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma. Am J Hum Genet. 2005;77:242-51 pubmed
    ..a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma (CEDNIK syndrome). Using homozygosity mapping in two large families, we localized the disease gene to 22q11...

More Information

Publications61

  1. Eguchi M, Ozaki E, Yamauchi T, Ohta M, Higaki T, Masuda K, et al. Manifestation of recessive combined D-2-, L-2-hydroxyglutaric aciduria in combination with 22q11.2 deletion syndrome. Am J Med Genet A. 2018;176:351-358 pubmed publisher
    ..Three genes present in the deleted 22q11.2 region, SLC25A1, TUBA8, and SNAP29, which have been reported to be associated with brain malformation, were analyzed for the presence of pathogenic ..
  2. Saleeb R, Kavanagh D, Dun A, Dalgarno P, Duncan R. A VPS33A-binding motif on syntaxin 17 controls autophagy completion in mammalian cells. J Biol Chem. 2019;294:4188-4201 pubmed publisher
    ..We show that autophagosomal syntaxin 17 (Stx17) heterotrimerizes with synaptosome-associated protein 29 (SNAP29) and vesicle-associated membrane protein 7 (VAMP7) in situ, highlighting a functional role for VAMP7 in ..
  3. Mastrodonato V, Beznoussenko G, Mironov A, Ferrari L, Deflorian G, Vaccari T. A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Sci Rep. 2019;9:1211 pubmed publisher
    Homozygous mutations in SNAP29, encoding a SNARE protein mainly involved in membrane fusion, cause CEDNIK (Cerebral Dysgenesis, Neuropathy, Ichthyosis and Keratoderma), a rare congenital neurocutaneous syndrome associated with short life ..
  4. Huang L, Yuan P, Yu P, Kong Q, Xu Z, Yan X, et al. O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. Int J Mol Med. 2018;42:3278-3290 pubmed publisher
    ..to elucidate the molecular regulation of autophagy by O‑GlcNAc‑modified synaptosomal‑associated protein 29 (SNAP29) in diabetic myocardial injury...
  5. Kadkova A, Radecke J, Sørensen J. The SNAP-25 Protein Family. Neuroscience. 2018;: pubmed publisher
  6. Xu H, Stewart B. Imaging SNAP-29 in Drosophila. Methods Mol Biol. 2019;1860:391-401 pubmed publisher
    ..Here we describe the protocol to localize SNAP-29 in early embryos, imaginal discs from third instar larva, and immortalized S2 cells via immunofluorescence microscopy. ..
  7. Valleau D, Little D, Borek D, Skarina T, Quaile A, Di Leo R, et al. Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli. Proc Natl Acad Sci U S A. 2018;115:10004-10009 pubmed publisher
    ..of the Mediator complex, while NleG2-3 resides in the host cytosol and triggers degradation of Hexokinase-2 and SNAP29. Our structural studies of NleG5-1 reveal a distinct N-terminal α/β domain that is responsible for interacting ..
  8. Takáts S, Nagy P, Varga Ã, Pircs K, Kárpáti M, Varga K, et al. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol. 2013;201:531-9 pubmed publisher
    ..Our findings reveal the molecular mechanism underlying autophagosomal fusion events and show that lysosomal degradation and recycling of sequestered autophagosome content is crucial to maintain proper functioning of the nervous system. ..
  9. Cordovez J, Capasso J, Lingao M, Sadagopan K, Spaeth G, Wasserman B, et al. Ocular manifestations of 22q11.2 microduplication. Ophthalmology. 2014;121:392-398 pubmed publisher
    ..The duplicated segment in case 1 includes SNAP29, which could be linked with the development of retinal vascular tortuosity, and MAPK1, which seems to play a role ..
  10. Wang C, Wang H, Zhang D, Luo W, Liu R, Xu D, et al. Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy. Nat Commun. 2018;9:3492 pubmed publisher
    ..Unphosphorylated ULK1 recruited STX17 and increased STX17's affinity towards synaptosomal-associated protein 29 (SNAP29)...
  11. Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed publisher
    ..YKT6 formed a SNARE complex with SNAP29 and lysosomal STX7, both of which are required for autophagosomal fusion...
  12. Usami M, Okada A, Taguchi K, Hamamoto S, Kohri K, Yasui T. Genetic differences in C57BL/6 mouse substrains affect kidney crystal deposition. Urolithiasis. 2018;46:515-522 pubmed publisher
    ..The expression levels of six genes (Snap29, Fgf14, Aplp2, Lims1, Naaladl2, and Nnt) were investigated by quantitative polymerase chain reaction, and the ..
  13. Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, et al. The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes. Mol Cell. 2016;63:781-95 pubmed publisher
    ..EPG5 also binds to LC3/LGG-1 (mammalian and C. elegans Atg8 homolog, respectively) and to assembled STX17-SNAP29 Qabc SNARE complexes on autophagosomes...
  14. Corona A, Saulsbery H, Corona Velazquez A, Jackson W. Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit. Cell Rep. 2018;22:3304-3314 pubmed publisher
    ..EV-D68 proteases cleave a major autophagic cargo adaptor and the autophagic SNARE SNAP29, which reportedly regulates fusion between autophagosome to amphisome/autolysosome...
  15. Mohamud Y, Shi J, Qu J, Poon T, Xue Y, Deng H, et al. Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication. Cell Rep. 2018;22:3292-3303 pubmed publisher
    ..Furthermore, we show that CVB3 specifically targets SNARE protein SNAP29 and adaptor protein PLEKHM1, two critical proteins known to regulate autophagosome fusion, for cleavage through ..
  16. Rapaport D, Fichtman B, Weidberg H, Sprecher E, Horowitz M. NEK3-mediated SNAP29 phosphorylation modulates its membrane association and SNARE fusion dependent processes. Biochem Biophys Res Commun. 2018;497:605-611 pubmed publisher
    ..Mutations in SNAP29 gene result in CEDNIK (Cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma) syndrome...
  17. Williams C, Savage J, Harper M, Moore S, Hers I, Poole A. Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets. Platelets. 2016;27:286-94 pubmed publisher
    ..b>SNAP29 is a tSNARE found in platelets, but whose role has not been defined...
  18. McLelland G, Lee S, McBride H, Fon E. Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system. J Cell Biol. 2016;214:275-91 pubmed publisher
    ..Syntaxin-17 remains associated with mature MDVs and forms a ternary SNARE complex with SNAP29 and VAMP7 to mediate MDV-endolysosome fusion in a manner dependent on the homotypic fusion and vacuole protein ..
  19. Dodson M, Liu P, Jiang T, Ambrose A, Luo G, Rojo de la Vega M, et al. Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction. Mol Cell Biol. 2018;38: pubmed publisher
    ..Specifically, arsenic disrupts formation of the STX17-SNAP29-VAMP8 SNARE complex, where SNAP29 mediates vesicle fusion through bridging STX17-containing autophagosomes to ..
  20. López Rivera E, Liu Y, Verbitsky M, Anderson B, Capone V, Otto E, et al. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. N Engl J Med. 2017;376:742-754 pubmed publisher
    ..In zebrafish embryos, an induced loss of function in snap29, aifm3, and crkl resulted in renal defects; the loss of crkl alone was sufficient to induce defects...
  21. Diggle C, Martinez Garay I, Molnar Z, Brinkworth M, White E, Fowler E, et al. A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development. PLoS ONE. 2017;12:e0174264 pubmed publisher
    ..This resulted in identification of an additional homozygous loss-of-function mutation in SNAP29, suggesting that SNAP29 deficiency, rather than TUBA8 deficiency, may underlie most or all of the ..
  22. Zhen Y, Li W. Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation. Autophagy. 2015;11:1608-22 pubmed publisher
    ..The direct association of mutant VPS33A(D251E) with the autophagic SNARE complex, STX17 (syntaxin 17)-VAMP8-SNAP29, was enhanced...
  23. Schiller S, Seebode C, Wieser G, Goebbels S, Mobius W, Horowitz M, et al. Establishment of Two Mouse Models for CEDNIK Syndrome Reveals the Pivotal Role of SNAP29 in Epidermal Differentiation. J Invest Dermatol. 2016;136:672-679 pubmed publisher
    Loss-of-function mutations in the synaptosomal-associated protein 29 (SNAP29) gene cause the cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma syndrome...
  24. Choi J, Won N, Park J, Jang S, Eom C, Choi Y, et al. From the Cover: Ethylmercury-Induced Oxidative and Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death: Involvement of Autophagosome-Lysosome Fusion Arrest. Toxicol Sci. 2016;154:27-42 pubmed
    ..resulted in minimal cytotoxicity, increased the levels of the autophagic SNARE complex STX17 (syntaxin 17)-VAMP8-SNAP29 without altering mRNA levels, but high dose of EtHg was cytotoxic...
  25. Fu R, Deng Q, Zhang H, Hu X, Li Y, Liu Y, et al. A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3. Cell Death Dis. 2018;9:243 pubmed publisher
    ..Mechanistically, we found that BBM blocked autophagosome-lysosome fusion by inhibiting the interaction of SNAP29 and VAMP8. Furthermore, BBM induced upregulation of BNIP3 and the interaction between SNAP29 and BNIP3...
  26. Gonzalez Lozano M, Klemmer P, Gebuis T, Hassan C, Van Nierop P, Van Kesteren R, et al. Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development. Sci Rep. 2016;6:35456 pubmed publisher
    ..SNARE proteins, Snap 29/47 and Stx 7/8/12, showed higher expression in immature animals...
  27. Kimura T, Jia J, Kumar S, Choi S, Gu Y, Mudd M, et al. Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy. EMBO J. 2017;36:42-60 pubmed publisher
    ..Thus, secretory autophagy utilizes a specialized cytosolic cargo receptor and a dedicated SNARE system. Other unconventionally secreted cargo, such as ferritin, is secreted via the same pathway. ..
  28. Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen R. SNAP-25 gene family members differentially support secretory vesicle fusion. J Cell Sci. 2017;130:1877-1889 pubmed publisher
    ..Furthermore, SNAP-25 homologs support DCV and SV fusion and neuronal viability to variable extents - SNAP-23 most effectively, SNAP-29 less so and SNAP-47 ineffectively. ..
  29. Lai J, Sam I, Verlhac P, Baguet J, Eskelinen E, Faure M, et al. 2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation. Viruses. 2017;9: pubmed publisher
    ..assay further showed that 2BC binds to SNARE proteins, STX17 and synaptosome associated protein 29 (SNAP29)...
  30. Sun D, Zhu L, Zhao Y, Jiang Y, Chen L, Yu Y, et al. Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer. Cell Prolif. 2018;51:e12402 pubmed publisher
    ..proteomics and network analyses revealed that Fluoxetine-induced mechanism was involved in BIRC6, BNIP1, SNAP29 and Bif-1...
  31. van Zuylen W, Doyon P, Clément J, Khan K, D Ambrosio L, Dô F, et al. Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. PLoS Pathog. 2012;8:e1002747 pubmed publisher
  32. Zhang J, Fu Y, Zhao Y, Li F, Qian A, Wu B, et al. [Genetic analysis of genitourinary malformations]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:134-8 pubmed publisher
    ..Potential mutation(s) in candidate gene SNAP29, whose expression pattern appeared to be unique, was screened in 44 patients and 220 normal controls with PCR-..
  33. Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, et al. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature. 2015;520:563-6 pubmed publisher
    ..target (t)-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) syntaxin 17 (STX17) and SNAP29, and the vesicle (v)-SNARE VAMP8 (vesicle-associated membrane protein 8)...
  34. Saito T, Guan F, Papolos D, Rajouria N, Fann C, Lachman H. Polymorphism in SNAP29 gene promoter region associated with schizophrenia. Mol Psychiatry. 2001;6:193-201 pubmed
    ..One plausible candidate gene that maps to 22q11, in a region deleted in the most common form of VCFS, is SNAP29, a member of the SNAP-25 family of SNARE proteins...
  35. Scales S, Chen Y, Yoo B, Patel S, Doung Y, Scheller R. SNAREs contribute to the specificity of membrane fusion. Neuron. 2000;26:457-64 pubmed
    ..The data suggest that SNARE pairing does underlie vesicle trafficking fidelity, and that specific SNARE interactions with other proteins may facilitate the correct pairing. ..
  36. Carroll J, Liu X, Brodsky A, Li W, Meyer C, Szary A, et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 2005;122:33-43 pubmed
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells. ..
  37. Li Q, Frank M, Akiyama M, Shimizu H, Ho S, Thisse C, et al. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Dis Model Mech. 2011;4:777-85 pubmed publisher
    ..To gain insight into epidermal morphogenesis, we have employed morpholino-mediated knockdown of the abca12 and snap29 genes, which are crucial for secretion of lipids and intracellular trafficking of lamellar granules, respectively...
  38. Hsu T, Coughlin C, Monaghan K, Fiala E, McKinstry R, Paciorkowski A, et al. CEDNIK: Phenotypic and Molecular Characterization of an Additional Patient and Review of the Literature. Child Neurol Open. 2017;4:2329048X17733214 pubmed publisher
    ..gene have been associated with cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma syndrome (CEDNIK). In patients with 22q11...
  39. McDonald McGinn D, Fahiminiya S, Revil T, Nowakowska B, Suhl J, Bailey A, et al. Hemizygous mutations in SNAP29 unmask autosomal recessive conditions and contribute to atypical findings in patients with 22q11.2DS. J Med Genet. 2013;50:80-90 pubmed publisher
    ..In four unrelated patients, we identified three novel mutations in SNAP29, the gene implicated in the autosomal recessive condition cerebral dysgenesis, neuropathy, ichthyosis and ..
  40. Morelli E, Mastrodonato V, Beznoussenko G, Mironov A, Tognon E, Vaccari T. An essential step of kinetochore formation controlled by the SNARE protein Snap29. EMBO J. 2016;35:2223-2237 pubmed
    ..Here, we identify a novel role for Snap29, an unconventional SNARE, in promoting kinetochore assembly during mitosis in Drosophila and human cells...
  41. Naegeli K, Hastie E, Garde A, Wang Z, Keeley D, Gordon K, et al. Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain. Dev Cell. 2017;43:403-417.e10 pubmed publisher
    ..Together these studies define a netrin-dependent pathway that builds an invasive protrusion, an isolated lysosome-derived membrane structure specialized to breach tissue barriers. ..
  42. Kuster A, Nola S, Dingli F, Vacca B, Gauchy C, Beaujouan J, et al. The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs). J Biol Chem. 2015;290:28056-69 pubmed publisher
    ..We conclude that SNAP-47 plays a role in the proper localization and function of a subset of VAMPs likely via regulation of their transport through the early secretory pathway. ..
  43. Jia R, Guardia C, Pu J, Chen Y, Bonifacino J. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy. 2017;13:1648-1663 pubmed publisher
    ..BORC KO also reduces the recruitment of the HOPS tethering complex to lysosomes and assembly of the STX17-VAMP8-SNAP29 trans-SNARE complex involved in autophagosome-lysosome fusion...
  44. Morelli E, Ginefra P, Mastrodonato V, Beznoussenko G, Rusten T, Bilder D, et al. Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy. 2014;10:2251-68 pubmed publisher
    ..of membrane trafficking, and predict that signaling defects may contribute to the pathogenesis of cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma (CEDNIK), a human congenital syndrome due to loss of Snap29.
  45. Guo B, Liang Q, Li L, Hu Z, Wu F, Zhang P, et al. O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nat Cell Biol. 2014;16:1215-26 pubmed publisher
    ..O-GlcNAcylated SNAP-29 levels are reduced during starvation in mammalian cells and in C. elegans. Our study reveals a mechanism by which O-GlcNAc-modification integrates nutrient status with autophagosome maturation. ..
  46. Martinez Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux Gillardeaux V, et al. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A. 2003;100:9011-6 pubmed
    ..Moreover, they point to the amino-terminal domains of SNARE proteins as multifunctional modules responsible for the fine tuning of SNARE function. ..
  47. Xu Y, Shi H, Wei S, Wong S, Hong W. Mutually exclusive interactions of EHD1 with GS32 and syndapin II. Mol Membr Biol. 2004;21:269-77 pubmed
    ..Opposing roles of GS32 and syndapin II in regulating the surface level of transferrin receptor (TfR) were observed. ..
  48. Ben Salem S, Nara S, Al Shamsi A, Valle D, Ali B, Al Gazali L. New Arab family with cerebral dysgenesis, neuropathy, ichthyosis and keratoderma syndrome suggests a possible founder effect for the c.223delG mutation. J Dermatol. 2015;42:821-2 pubmed publisher
  49. Lu Q, Insinna C, Ott C, Stauffer J, Pintado P, Rahajeng J, et al. Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nat Cell Biol. 2015;17:228-240 pubmed publisher
    ..b>SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle ..
  50. Scifo E, Pabba M, Kapadia F, Ma T, Lewis D, Tseng G, et al. Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder. Biol Psychiatry. 2018;83:81-89 pubmed publisher
    ..Collectively, the results provide evidence for persistent MDD effects across current episodes or remission, in the absence of detectable progressive neuropathology. ..
  51. Itakura E, Kishi Itakura C, Mizushima N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 2012;151:1256-69 pubmed publisher
    ..These findings reveal a mechanism by which the SNARE protein is available to the completed autophagosome...
  52. Csizmadia T, Lorincz P, Hegedus K, Széplaki S, Low P, Juhasz G. Molecular mechanisms of developmentally programmed crinophagy in Drosophila. J Cell Biol. 2018;217:361-374 pubmed publisher
    ..the small GTPases Rab2, Rab7, and its effector, PLEKHM1; and a SNAP receptor complex consisting of Syntaxin 13, Snap29, and Vamp7 are all required for the fusion of secretory granules with lysosomes...