SNAP23

Summary

Gene Symbol: SNAP23
Description: synaptosome associated protein 23
Alias: HsT17016, SNAP-23, SNAP23A, SNAP23B, synaptosomal-associated protein 23, synaptosomal-associated protein, 23kD, synaptosomal-associated protein, 23kDa, synaptosome associated protein 23kDa, vesicle-membrane fusion protein SNAP-23
Species: human
Products:     SNAP23

Top Publications

  1. Foster L, Yeung B, Mohtashami M, Ross K, Trimble W, Klip A. Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation. Biochemistry. 1998;37:11089-96 pubmed
    ..In this study, we defined the binding characteristics of three SNARE proteins: SNAP23, VAMP-2, and syntaxin-4...
  2. Cabaniols J, Ravichandran V, Roche P. Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. Mol Biol Cell. 1999;10:4033-41 pubmed
    ..These data demonstrate that phosphorylation of SNAP-23 by SNAK enhances the kinetics of t-SNARE assembly in vivo. ..
  3. Schraw T, Lemons P, Dean W, Whiteheart S. A role for Sec1/Munc18 proteins in platelet exocytosis. Biochem J. 2003;374:207-17 pubmed publisher
    ..These studies demonstrate a clear role for SM proteins in platelet exocytosis and aggregation and suggest a dominant role for Munc18c in all three granule-release events...
  4. Reales E, Mora López F, Rivas V, García Poley A, Brieva J, Campos Caro A. Identification of soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in human plasma cells: SNAP-23 is essential for antibody secretion. J Immunol. 2005;175:6686-93 pubmed
    ..These results provide insights, for the first time, into the molecular machinery of constitutive vesicular trafficking in human PC Ig secretion and present evidence indicating that at least SNAP-23 is essential for Ab production. ..
  5. Sander L, Frank S, Bolat S, Blank U, Galli T, Bigalke H, et al. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol. 2008;38:855-63 pubmed publisher
    ..In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation...
  6. Kawanishi M, Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M. Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2. J Biol Chem. 2000;275:8240-7 pubmed
    ..Synaptosome-associated 23-kDa protein (SNAP23) is a widely expressed isoform of SNAP25, the principal t-SNARE of neuronal cells, and colocalizes with syntaxin4 ..
  7. Kean M, Williams K, Skalski M, Myers D, Burtnik A, Foster D, et al. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. J Cell Sci. 2009;122:4089-98 pubmed publisher
    ..Using the invasive human fibrosarcoma cell line HT-1080, we demonstrate that a plasma membrane SNARE, SNAP23, and an endosomal v-SNARE, VAMP3 (also known as cellubrevin), partly colocalize with MMP2 and MMP9, and that ..
  8. Martin Martin B, Nabokina S, Blasi J, Lazo P, Mollinedo F. Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. Blood. 2000;96:2574-83 pubmed
    ..Syntaxin 6 acts as a target for secretion of specific and azurophilic granules, whereas SNAP-23 mediates specific granule secretion. ..
  9. Uriarte S, Rane M, Luerman G, Barati M, Ward R, Nauseef W, et al. Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. J Immunol. 2011;187:391-400 pubmed publisher

More Information

Publications110 found, 100 shown here

  1. Polgar J, Lane W, Chung S, Houng A, Reed G. Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem. 2003;278:44369-76 pubmed
    ..Because mutants that mimic SNAP-23 phosphorylation affect syntaxin 4 interactions, we hypothesize that SNAP-23 phosphorylation may be important for modulating SNARE-complex interactions during membrane trafficking and fusion. ..
  2. Weber P, Batoulis H, Rink K, Dahlhoff S, Pinkwart K, Sollner T, et al. Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane. elife. 2017;6: pubmed publisher
    The SNAREs SNAP25 and SNAP23 are proteins that are initially cytosolic after translation, but then become stably attached to the cell membrane through palmitoylation of cysteine residues...
  3. Kwofie S, Dankwa B, Enninful K, Adobor C, Broni E, Ntiamoah A, et al. Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis. Toxins (Basel). 2019;11: pubmed publisher
    ..proteins and regulators, namely Vesicle-associated membrane protein (VAMP8), Synaptosomal-associated protein (SNAP23, syntaxin 11, Munc13-4 (its isoform Munc13-1 was used), and Munc18b; and also against known mycolactone targets (..
  4. Zhu J, LIU Y, Zhang Y, Zhao C, Yao W, Li Y, et al. VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia. Proc Natl Acad Sci U S A. 2017;114:8271-8276 pubmed publisher
    ..the activation of SNAREs, vesicle-associated membrane protein 3 (VAMP3) and synaptosomal-associated protein 23 (SNAP23)...
  5. Højlund K. Metabolism and insulin signaling in common metabolic disorders and inherited insulin resistance. Dan Med J. 2014;61:B4890 pubmed
    ..In type 2 diabetes an altered intracellular distribution of SNAP23 and impaired activation of RAC1 also seem to play a role for reduced insulin action on glucose transport...
  6. Galli T, Zahraoui A, Vaidyanathan V, Raposo G, Tian J, Karin M, et al. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol Biol Cell. 1998;9:1437-48 pubmed
    ..In this study we found that syntaxin 3, SNAP23, and a newly identified VAMP/brevin, tetanus neurotoxin (TeNT)-insensitive VAMP (TI-VAMP), are insensitive to ..
  7. Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, et al. Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. J Clin Invest. 2014;124:4517-28 pubmed publisher
    ..studies showed that STXBP5 interacts with core secretion machinery complexes, such as syntaxin-11/SNAP23 heterodimers, and fractionation studies suggested that STXBP5 also interacts with the platelet cytoskeleton...
  8. Qiu H, Zmina P, Huang A, Askew D, Bedogni B. Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties. Cancer Lett. 2018;434:144-151 pubmed publisher
    ..Notch1 controls the transcription of IL8 and IL6; and the secretion of CCL5 likely by inhibiting the expression of SNAP23, a member of the SNAREs family of proteins involved in cell exocytosis...
  9. Frank S, Thon K, Bischoff S, Lorentz A. SNAP-23 and syntaxin-3 are required for chemokine release by mature human mast cells. Mol Immunol. 2011;49:353-8 pubmed publisher
    ..In summary, STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells whereas other SNAREs affect only release of selected chemokines. ..
  10. Sadler J, Bryant N, Gould G. Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking. Mol Biol Cell. 2015;26:530-6 pubmed publisher
    ..The t-SNARE complex consists of Syntaxin4 and SNAP23, and whereas many studies identify VAMP2 as the v-SNARE, others suggest that either VAMP3 or VAMP8 may also fulfil ..
  11. Yoon M, Won K, Kim D, Hwang D, Yoon S, Jung S, et al. Diminished Lipid Raft SNAP23 Increases Blood Pressure by Inhibiting the Membrane Fluidity of Vascular Smooth-Muscle Cells. J Vasc Res. 2015;52:321-33 pubmed publisher
    Synaptosomal-associated protein 23 (SNAP23) is involved in microvesicle trafficking and exocytosis in various cell types, but its functional role in blood pressure (BP) regulation has not yet been defined...
  12. Li H, Liu S, Sun X, Yang J, Yang Z, Shen H, et al. Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats. Neurobiol Dis. 2018;110:82-92 pubmed publisher
    ..Synaptosome associated protein 23 (SNAP23) and SNAP25 are respectively participate in presynaptic glutamate release and postsynaptic glutamate receptor (..
  13. Verweij F, Bebelman M, Jimenez C, Garcia Vallejo J, Janssen H, Neefjes J, et al. Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling. J Cell Biol. 2018;217:1129-1142 pubmed publisher
    ..Quantitative analysis demonstrates that MVB-PM fusion frequency is reduced by depleting the target membrane SNAREs SNAP23 and syntaxin-4 but also can be induced in single cells by stimulation of the histamine H1 receptor (H1HR)...
  14. Zhu B, Zhang Q, Wu Y, Luo J, Zheng X, Xu L, et al. SNAP23 suppresses cervical cancer progression via modulating the cell cycle. Gene. 2018;673:217-224 pubmed publisher
    ..In this study, we identified SNAP23 as a potential tumor suppressor gene in CC...
  15. Cormet Boyaka E, Di A, Chang S, Naren A, Tousson A, Nelson D, et al. CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex. Proc Natl Acad Sci U S A. 2002;99:12477-82 pubmed
    ..We conclude that CFTR channels are regulated by a t-SNARE complex that may tune CFTR activity to rates of membrane traffic in epithelial cells. ..
  16. Buxton P, Zhang X, Walsh B, Sriratana A, Schenberg I, Manickam E, et al. Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. Biochem J. 2003;375:433-40 pubmed
    ..Furthermore, using protein-protein-interaction assays we show that Snapin interacts with SNAP23, the widely expressed homologue of SNAP25, and that the predicted C-terminal helical domain of Snapin contains the ..
  17. Gómez Jaramillo L, Romero García R, Jiménez Gómez G, Riegle L, Ramos Amaya A, Brieva J, et al. VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins. Cell Mol Immunol. 2018;15:353-366 pubmed publisher
    ..We have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody secretion...
  18. Kociucka B, Flisikowska T, Mróz D, Szczerbal I. Expression of genes involved in lipid droplet formation (BSCL2, SNAP23 and COPA) during porcine in vitro adipogenesis. J Appl Genet. 2016;57:505-510 pubmed
    ..In the present study, expression of three genes involved in lipid droplet formation (SNAP23, BSCL2 and COPA) was evaluated during porcine adipogenesis...
  19. Li M, Wang J, Niu T, Ma J, Seneviratne C, Ait Daoud N, et al. Transcriptome profiling and pathway analysis of genes expressed differentially in participants with or without a positive response to topiramate treatment for methamphetamine addiction. BMC Med Genomics. 2014;7:65 pubmed publisher
    ..Many of these genes, such as GRINA, PRKACA, PRKCI, SNAP23, and TRAK2, which are involved in glutamate receptor and GABA receptor signaling, are direct targets for TPM...
  20. Carvalho E, Schellhorn S, Zabolotny J, Martin S, Tozzo E, Peroni O, et al. GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase. J Biol Chem. 2004;279:21598-605 pubmed
    ..The amount and subcellular distribution of syntaxin4, SNAP23, Munc-18c, and GLUT1 were unchanged in either aP2-GLUT4-/- or aP2-GLUT4-Tg adipocytes, but transferrin receptor ..
  21. Almamy A, Schwerk C, Schroten H, Ishikawa H, Asif A, Reuss B. Crossreactivity of an Antiserum Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae with the SNARE-Complex Protein Snap23 Correlates to Impaired Exocytosis in SH-SY5Y Cells. J Mol Neurosci. 2017;62:163-180 pubmed publisher
    ..with a first trimester prenatal brain multiprotein array, revealing among others the SNARE-complex protein Snap23 as a target antigen for α-NG...
  22. Ohbayashi N, Fukuda M. SNARE dynamics during melanosome maturation. Biochem Soc Trans. 2018;46:911-917 pubmed publisher
    ..Such SNARE dynamics, especially the SNARE recycling system, on melanosomes will be useful in understanding as yet unidentified SNARE dynamics on other organelles. ..
  23. Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber L, Cenac N, et al. Different activation signals induce distinct mast cell degranulation strategies. J Clin Invest. 2016;126:3981-3998 pubmed publisher
    ..during IgE-dependent stimulation strongly reduced the time partition between signaling and secretion, inhibited SNAP23/STX4 complex formation, and switched the degranulation pattern into one that resembled degranulation induced by ..
  24. Peschke K, Weitzmann A, Heger K, Behrendt R, Schubert N, Scholten J, et al. IκB kinase 2 is essential for IgE-induced mast cell de novo cytokine production but not for degranulation. Cell Rep. 2014;8:1300-7 pubmed publisher
    ..2 (IKK2) was reported to couple IgE-induced signals to MC degranulation by phosphorylating the SNARE protein SNAP23. We investigated MC responses in mice with MC-specific inactivation of IKK2 or NF-κB essential modulator (NEMO),..
  25. Wasik A, Dumont V, Tienari J, Nyman T, Fogarty C, Forsblom C, et al. Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion. Exp Cell Res. 2017;350:336-348 pubmed publisher
    ..Both septin 7 and NM-IIA associate with SNAP23, a SNARE protein involved in GLUT4 storage vesicle (GSV) docking and fusion with the plasma membrane...
  26. Guo Z, Turner C, Castle D. Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell. 1998;94:537-48 pubmed
    ..After relocation, SNAP-23 is required for exocytosis, implying a crucial role in promoting membrane fusion. Thus, relocation of this SNARE regulates compound exocytosis and links granule-plasma membrane and granule-granule fusions. ..
  27. Vigelsø A, Gram M, Wiuff C, Hansen C, Prats C, Dela F, et al. Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men. Eur J Appl Physiol. 2016;116:481-94 pubmed publisher
    ..substrates; muscle perilipin protein (PLIN), glycogen synthase (GS), synaptosomal-associated protein of 23 kDa (SNAP23) protein content, and muscle 3-hydroxyacyl-CoA dehydrogenase (HAD) activity The older men had higher intramuscular ..
  28. Boal F, Zhang H, Tessier C, Scotti P, Lang J. The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. Biochemistry. 2004;43:16212-23 pubmed
    ..Our data suggest that both interactions of Csp occur during exocytosis and may explain the effect of the variant C-terminus of this chaperon protein on peptide hormone secretion. ..
  29. Gu Y, Chiu S, Liu B, Wu P, Delannoy M, Lin D, et al. Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci U S A. 2016;113:E922-31 pubmed publisher
    ..of AMPA receptors requires SNAP25-syntaxin1A/B-VAMP2 complexes, whereas insertion of GABAA receptors relies on SNAP23-syntaxin1A/B-VAMP2 complexes...
  30. Lin M, Jiang M, Ding F, Cao Z. Syntaxin-4 and SNAP23 act as exocytic SNAREs to release NGF from cultured Schwann cells. Neurosci Lett. 2017;653:97-104 pubmed publisher
    ..We found that Syntaxin-4 and SNAP23 were co-localized with NGF by immunocytochemistry...
  31. Kubo K, Kobayashi M, Nozaki S, Yagi C, Hatsuzawa K, Katoh Y, et al. SNAP23/25 and VAMP2 mediate exocytic event of transferrin receptor-containing recycling vesicles. Biol Open. 2015;4:910-20 pubmed publisher
    ..We showed that exocyst subunits, Sec6 and Sec8, can interact with SNAP23 and SNAP25, both of which are PM-localizing Qbc-SNAREs, and that depletion of SNAP23 and/or SNAP25 in HeLa cells ..
  32. Steegmaier M, Yang B, Yoo J, Huang B, Shen M, Yu S, et al. Three novel proteins of the syntaxin/SNAP-25 family. J Biol Chem. 1998;273:34171-9 pubmed
    ..SNAP-29 does not contain a predicted membrane anchor characteristic of other SNAREs. In vitro studies established that SNAP-29 is capable of binding to a broad range of syntaxins. ..
  33. Kunii M, Ohara Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, et al. Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells. J Cell Biol. 2016;215:121-138 pubmed
    ..Synaptosomal-associated protein 23 (SNAP23), a soluble N-ethyl-maleimide sensitive fusion protein attachment protein receptor (SNARE) molecule, is essential ..
  34. Viswanathan M, Mullainadhan V, Chinnaiyan M, Karundevi B. Effects of DEHP and its metabolite MEHP on insulin signalling and proteins involved in GLUT4 translocation in cultured L6 myotubes. Toxicology. 2017;386:60-71 pubmed publisher
    ..proteins in skeletal muscle), insulin - regulated amino peptidase (IRAP), synaptosomal - associated protein 23 (SNAP23), Syntaxin4, Munc18c) from cytosol to plasma membrane...
  35. Greaves J, Gorleku O, Salaun C, Chamberlain L. Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases. J Biol Chem. 2010;285:24629-38 pubmed publisher
    ..b>SNAP23 is 60% identical to SNAP25 and has a distinct cysteine-rich domain to both SNAP25a and SNAP25b...
  36. Nair Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, et al. TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation. Cell. 2014;158:506-21 pubmed publisher
    ..with MHC-I, MyD88-dependent TLR signals drive I?B-kinase (IKK)2-mediated phosphorylation of phagosome-associated SNAP23. Phospho-SNAP23 stabilizes SNARE complexes orchestrating ERC-phagosome fusion, enrichment of phagosomes with ERC-..
  37. Liu D, Xu X, Zhuang M, Song M, Qin W, Wang X, et al. [Suppressive effect of exogenous carbon monoxide on abnormal platelet exocytosis and its molecular mechanism in sepsis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016;28:110-6 pubmed publisher
    ..complex formation [syntaxin 2-synaptosomal-associated protein 23-vesicle associated membrane protein 8 (STX2-SNAP23-VAMP8)] mediated by STXBP-1 was determined by immunoprecipitation...
  38. Ren B, Azzegagh Z, Jaramillo A, Zhu Y, Pardo Saganta A, Bagirzadeh R, et al. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. Biosci Rep. 2015;35: pubmed publisher
    ..We find the trafficking protein, SNAP23 (23-kDa paralogue of synaptosome-associated protein of 25 kDa), selectively expressed in secretory cells compared ..
  39. Williams C, Savage J, Harper M, Moore S, Hers I, Poole A. Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets. Platelets. 2016;27:286-94 pubmed publisher
    ..These data suggest that SNAP29 contributes to the regulation of platelet α-granule secretion and thrombus stability, possibly partially masked by functional redundancy with other tSNAREs, such as SNAP23.
  40. Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, et al. Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3. J Lipid Res. 2018;59:805-819 pubmed publisher
    ..Moreover, we show that the interaction between Stx17 and ACSL3 during LD maturation may be regulated by synaptosomal-associated protein of 23 kDa. ..
  41. Martín Ávila A, Medina Tamayo J, Ibarra Sanchez A, Vázquez Victorio G, Castillo Arellano J, Hernández Mondragón A, et al. Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKC?/? Signaling Node Leading to TNF Secretion. J Immunol. 2016;196:5075-88 pubmed publisher
  42. Zhuang M, Sun B, Liu D, Shi Y. [Suppressive effect of CORM-2 on platelet α-granule exocytosis in sepsis via SNARE/Munc18b complex formation]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:156-161 pubmed publisher
    ..01). Above all, the data showed a dose dependent change. We could suggest that CORM-2 suppressed α-granule exocytosis in LPS-stimulated platelets and the potential mechanisms might involve SNARE/Munc18b complex formation. ..
  43. Freedman S, Song H, Xu Y, Sun Z, Eck M. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. J Biol Chem. 2003;278:13462-7 pubmed
    ..A comparison of the SNAP-23N structure to other SNARE complex structures reveals how a simple coiled-coil motif can form diverse SNARE complexes. ..
  44. Bhat R, Bhattacharyya P, Ratech H. An Immunohistochemical Survey of SNARE Proteins Shows Distinct Patterns of Expression in Hematolymphoid Neoplasia. Am J Clin Pathol. 2016;145:604-16 pubmed publisher
    ..7 (STX7), vesicle-associated membrane proteins (VAMP2, VAMP7, VAMP8), and synaptosomal-associated protein 23 (SNAP23)...
  45. Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, et al. Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. J Immunol. 2000;164:5850-7 pubmed
    ..Among those, synaptosome-associated protein of 23 kDa (SNAP23) was central in SNARE complex formation...
  46. Williams K, McNeilly R, Coppolino M. SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion. Mol Biol Cell. 2014;25:2061-70 pubmed publisher
    ..During invadopodium formation in MDA-MB-231 human breast cancer cells, increased association of SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) is detected by coimmunoprecipitation...
  47. Lemonidis K, Sanchez Perez M, Chamberlain L. Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases. J Biol Chem. 2015;290:21939-50 pubmed publisher
    ..their AR domain, evolutionary conserved and closely related sequences of a [VIAP][VIT]XXQP consensus in SNAP25, SNAP23, cysteine string protein, Huntingtin, cytoplasmic linker protein 3, and microtubule-associated protein 6...
  48. Kociucka B, Jackowiak H, Kamyczek M, Szydlowski M, Szczerbal I. The relationship between adipocyte size and the transcript levels of SNAP23, BSCL2 and COPA genes in pigs. Meat Sci. 2016;121:12-18 pubmed publisher
    ..three tissues (subcutaneous, visceral and longissimus dorsi muscle) in relation to transcript levels of genes (SNAP23, BSCL2 and COPA), which encode proteins involved in lipid droplet formation...
  49. Armstrong C, Miralda I, Neff A, Tian S, Vashishta A, Pérez L, et al. Filifactor alocis Promotes Neutrophil Degranulation and Chemotactic Activity. Infect Immun. 2016;84:3423-3433 pubmed
    ..Blocking neutrophil degranulation with TAT-SNAP23 fusion protein significantly reduced the chemotactic and random migration induced by F...
  50. Vogel G, Klee K, Janecke A, Müller T, Hess M, Huber L. Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. J Cell Biol. 2015;211:587-604 pubmed publisher
    ..Hence, our work demonstrates how Myo5B, Stx3, Slp4a, Vamp7, Munc18-2, and Rab8/11 cooperate during selective apical cargo trafficking and exocytosis in epithelial cells and thereby provides further insight into MVID pathophysiology. ..
  51. Okamoto M, Schoch S, Sudhof T. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?. J Biol Chem. 1999;274:18446-54 pubmed
    ..The ability of multiple SH3 domains in EHSH1 to bind to dynamin suggests that EHSH1 can cluster several dynamin molecules in a manner that is regulated by alternative splicing. ..
  52. Logan M, Lacy P, Odemuyiwa S, Steward M, Davoine F, Kita H, et al. A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy. 2006;61:777-84 pubmed
    ..Our observations indicate for the first time a critical role for VAMP-7 in both eosinophil and neutrophil mediator release. ..
  53. Widberg C, Bryant N, Girotti M, Rea S, James D. Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J Biol Chem. 2003;278:35093-101 pubmed
    ..study we have investigated the interaction between b-Tomosyn and the adipocyte SNARE complex involving Syntaxin4/SNAP23/VAMP-2 and the SM protein Munc18c, in vitro, and the potential involvement of Tomosyn in regulating the ..
  54. Brochetta C, Vita F, Tiwari N, Scandiuzzi L, Soranzo M, Guérin Marchand C, et al. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. Biochim Biophys Acta. 2008;1783:1781-91 pubmed publisher
    ..Our results suggest that Munc18-2 acts as a regulator of primary granule exocytosis, while Munc18-3 may preferentially regulate the fusion of secondary granules. ..
  55. Williams K, Coppolino M. SNARE-dependent interaction of Src, EGFR and ?1 integrin regulates invadopodia formation and tumor cell invasion. J Cell Sci. 2014;127:1712-25 pubmed publisher
    ..and ?1 integrin is dependent upon membrane traffic that is mediated by syntaxin13 (officially known as STX12) and SNAP23; a similar dependence on these two SNARE proteins was observed for invadopodium-based matrix degradation and cell ..
  56. Benítez B, Sands M. Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis. Sci Rep. 2017;7:6332 pubmed publisher
    ..Overexpression of CSPα wild-type (WT) decreases lysotracker signal, secreted lysosomal enzymes and SNAP23-mediated lysosome exocytosis...
  57. Klein O, Roded A, Zur N, Azouz N, Pasternak O, Hirschberg K, et al. Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis. Sci Rep. 2017;7:15315 pubmed publisher
    ..Moreover, we show that Rab5 is essential for FcεRI-triggered association of the SNARE protein SNAP23 with the SGs...
  58. Mollinedo F, Lazo P. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. Biochem Biophys Res Commun. 1997;231:808-12 pubmed
    ..These findings demonstrate the existence of two SNAP-23 proteins in human neutrophils; and therefore, these cells have all the proteins needed to carry out the exocytic process. ..
  59. Gerelsaikhan T, Vasa P, Chander A. Annexin A7 and SNAP23 interactions in alveolar type II cells and in vitro: a role for Ca(2+) and PKC. Biochim Biophys Acta. 2012;1823:1796-806 pubmed publisher
    ..In this study, we investigated in vivo and in vitro interactions of A7 with the t-SNARE protein, SNAP23. Immuno-fluorescence studies showed time-dependent increases in co-localization of A7 with SNAP23 in PMA- and in ..
  60. Yamamoto K, Ishii E, Horiuchi H, Ueda I, Ohga S, Nishi M, et al. Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people. J Hum Genet. 2005;50:600-3 pubmed
    ..We evaluated mutations of syntaxin 11 and SNAP23 genes in 30 Japanese FHL patients...
  61. Strauss J, Shaw C, Bradley H, Wilson O, Dorval T, Pilling J, et al. Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria. Physiol Rep. 2016;4: pubmed publisher
    Synaptosomal-associated protein 23 (SNAP23) is a SNARE protein expressed abundantly in human skeletal muscle...
  62. Diefenbach R, Diefenbach E, Douglas M, Cunningham A. The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23. Biochemistry. 2002;41:14906-15 pubmed
    ..Subsequently, synaptosome-associated protein of 23 kDa (SNAP23), the nonneuronal homologue of SNAP25, was also confirmed to interact with kinesin...
  63. Riento K, Galli T, Jansson S, Ehnholm C, Lehtonen E, Olkkonen V. Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. J Cell Sci. 1998;111 ( Pt 17):2681-8 pubmed
    ..These results define a novel functional complex of Munc-18-2 and syntaxin 3 involved in the regulation of apical membrane transport. ..
  64. Liu S, Sharon Friling R, Ivanova P, Milne S, Myers D, Rabinowitz J, et al. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci U S A. 2011;108:12869-74 pubmed publisher
    ..We propose that cytomegalovirus capsids acquire their envelope by budding into vesicles with a lipid composition similar to that of synaptic vesicles, which subsequently fuse with the plasma membrane to release virions from the cell. ..
  65. Karim Z, Vemana H, Khasawneh F. MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation. PLoS ONE. 2015;10:e0119363 pubmed publisher
    ..Thus, our data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing platelet signals to the NF-κB pathway. ..
  66. Polgar J, Chung S, Reed G. Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. Blood. 2002;100:1081-3 pubmed
    ..In contrast, rVAMP-2, which formed SNARE complexes in vitro, had no effect on platelet exocytosis. We conclude that VAMP-3 and VAMP-8 form SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion. ..
  67. Rüder C, Reimer T, Delgado Martinez I, Hermosilla R, Engelsberg A, Nehring R, et al. EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin. Mol Biol Cell. 2005;16:1245-57 pubmed
    ..of Snapin; subsequently, association of Snapin with synaptosome-associated protein of 25 kDa (SNAP25) and SNAP23 was diminished...
  68. Ravichandran V, Chawla A, Roche P. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. J Biol Chem. 1996;271:13300-3 pubmed
    ..These findings suggest that SNAP-23 is an essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion in all mammalian cells. ..
  69. Imai A, Nashida T, Yoshie S, Shimomura H. Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. Arch Oral Biol. 2003;48:597-604 pubmed
    ..Many SNARE complexes were detected under non-stimulated/basic conditions in the parotid APM. Some of these complexes may have a role in exocytosis from parotid acinar cells. ..
  70. Min A, Lee Y, Kim K, El Benna J, Shin M. SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4. Infect Immun. 2017;85: pubmed publisher
    ..In this study, we found that SNAP23-dependent surface trafficking of LTB4 receptor 1 (BLT1) is required for nicotinamide adenine ..
  71. Rutledge T, Whiteheart S. SNAP-23 is a target for calpain cleavage in activated platelets. J Biol Chem. 2002;277:37009-15 pubmed
    ..This is consistent with the ultrastructural morphology of calpeptin-treated platelets after activation. ..
  72. Sahid M, Liu S, Kiyoi T, Maeyama K. Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins. Eur J Pharmacol. 2017;814:255-263 pubmed publisher
    ..and the plasma membrane, such as Ras-like protein in the brain 27a (Rab27a), synaptosome-associated protein 23 (SNAP23), and vesicle-associated membrane protein 7 (VAMP7), as well as Ca2+ binding proteins, such as double ..
  73. Brasher M, Martynowicz D, Grafinger O, Hucik A, Shanks Skinner E, Uniacke J, et al. Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells. J Biol Chem. 2017;292:16199-16210 pubmed publisher
    ..associates with Munc18c and inhibits endogenous interactions of Stx4 with synaptosome-associated protein 23 (SNAP23) and vesicle-associated membrane protein 2 (VAMP2)...
  74. Pallavi B, Nagaraj R. Palmitoylated peptides from the cysteine-rich domain of SNAP-23 cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation. J Biol Chem. 2003;278:12737-44 pubmed
    ..Our results suggest an important role for the cysteine-rich palmitoylated domain of SNAP-23 in promoting membrane fusion in cells. ..
  75. Flaumenhaft R, Rozenvayn N, Feng D, Dvorak A. SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane. Blood. 2007;110:1492-501 pubmed
    ..These observations represent the first description of SNARE proteins on the extracellular surface of a cell. ..
  76. Sakurai C, Hashimoto H, Nakanishi H, Arai S, Wada Y, Sun Wada G, et al. SNAP-23 regulates phagosome formation and maturation in macrophages. Mol Biol Cell. 2012;23:4849-63 pubmed publisher
    ..Taken together, our results strongly suggest the involvement of SNAP-23 in both phagosome formation and maturation in macrophages, presumably by mediating SNARE-based membrane traffic. ..
  77. Valdez A, Cabaniols J, Brown M, Roche P. Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. J Cell Sci. 1999;112 ( Pt 6):845-54 pubmed
    ..These data suggest that syntaxin 11 is a SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network in mammalian cells. ..
  78. Kioumourtzoglou D, Gould G, Bryant N. Proximity Ligation Assay to Study the GLUT4 Membrane Trafficking Machinery. Methods Mol Biol. 2018;1713:217-227 pubmed publisher
    ..in adipocytes and muscle cells, and mediated by formation of functional SNARE complexes containing Syntaxin4, SNAP23, and VAMP2...
  79. Logan M, Lacy P, Bablitz B, Moqbel R. Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis. J Allergy Clin Immunol. 2002;109:299-306 pubmed
    ..These findings support a role for SNARE molecules in eosinophil mediator release. ..
  80. Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, et al. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. EMBO J. 2004;23:1267-78 pubmed
    ..The present results disclose an unexpected role for a spindle checkpoint protein, ZW10, during interphase. ..
  81. Lim Y, Ngo H, Lee J, Son K, Park E, Hwang S. ADP-ribosylation Factor-related Protein 1 Interacts with NS5A and Regulates Hepatitis C Virus Propagation. Sci Rep. 2016;6:31211 pubmed publisher
    ..Moreover, ARFRP1 recruited synaptosomal-associated protein 23 (SNAP23) to sites in close proximity to LDs in HCV-infected cells...
  82. Guo Z, Liu L, Cafiso D, Castle D. Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide. J Biol Chem. 2002;277:35357-63 pubmed
    ..These findings identify a new reagent for analyzing the final stage of exocytosis and point to the likely action of SCAMP2 in this process. ..
  83. Boddul S, Meng J, Dolly J, Wang J. SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNF? from a human synovial sarcoma cell line. FEBS J. 2014;281:750-65 pubmed publisher
    ..Collectively, these results show that SNAP-23 and VAMP-3 participate in IL-1?-induced Ca²?-dependent release of IL-6 and TNF? from SW982 cells. ..
  84. Inoue T, Nielsen S, Mandon B, Terris J, Kishore B, Knepper M. SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles. Am J Physiol. 1998;275:F752-60 pubmed
    ..However, localization of SNAP-23 in both intracytoplasmic vesicles and plasma membranes suggests a function different from that originally proposed for SNAP-25 in synaptic vesicle targeting. ..
  85. Martinez Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux Gillardeaux V, et al. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A. 2003;100:9011-6 pubmed
    ..Moreover, they point to the amino-terminal domains of SNARE proteins as multifunctional modules responsible for the fine tuning of SNARE function. ..
  86. Kuster A, Nola S, Dingli F, Vacca B, Gauchy C, Beaujouan J, et al. The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs). J Biol Chem. 2015;290:28056-69 pubmed publisher
    ..We conclude that SNAP-47 plays a role in the proper localization and function of a subset of VAMPs likely via regulation of their transport through the early secretory pathway. ..
  87. Sun Q, Huang X, Zhang Q, Qu J, Shen Y, Wang X, et al. SNAP23 promotes the malignant process of ovarian cancer. J Ovarian Res. 2016;9:80 pubmed
    ..Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC...
  88. Dgany O, Avidan N, Delaunay J, Krasnov T, Shalmon L, Shalev H, et al. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Am J Hum Genet. 2002;71:1467-74 pubmed
    ..The specific mechanisms by which codanin-1 underlies normal erythropoiesis remain to be elucidated. ..
  89. Okayama M, Arakawa T, Mizoguchi I, Tajima Y, Takuma T. SNAP-23 is not essential for constitutive exocytosis in HeLa cells. FEBS Lett. 2007;581:4583-8 pubmed
    ..Furthermore, over-expression of deltaC8-SNAP-23, a dominant-negative mutant of SNAP-23, did not abrogate SEAP secretion. These results suggest that SNAP-23 is not essential for constitutive exocytosis of SEAP. ..
  90. Lu M, Forsberg L, Höög A, Juhlin C, Vukojevic V, Larsson C, et al. Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. Mol Cell Endocrinol. 2008;287:72-80 pubmed publisher
    ..1micromol/l). SNAP-25 (and Syntaxin1) appears to be a tumour-specific protein(s) in parathyroid tissues since its expression was restricted to pathological tissues. ..
  91. Li G, Alexander E, Schwartz J. Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis. J Biol Chem. 2003;278:19791-7 pubmed publisher
    ..Interaction between the syntaxin-1A and H+-ATPase is important in the targeted exocytosis of the proton pump to the apical membrane of intercalated cells...
  92. Scales S, Chen Y, Yoo B, Patel S, Doung Y, Scheller R. SNAREs contribute to the specificity of membrane fusion. Neuron. 2000;26:457-64 pubmed
    ..The data suggest that SNARE pairing does underlie vesicle trafficking fidelity, and that specific SNARE interactions with other proteins may facilitate the correct pairing. ..