Gene Symbol: SMOC1
Description: SPARC related modular calcium binding 1
Alias: OAS, SPARC-related modular calcium-binding protein 1, secreted modular calcium-binding protein 1
Species: human
Products:     SMOC1

Top Publications

  1. Vannahme C, Smyth N, Miosge N, Gösling S, Frie C, Paulsson M, et al. Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes. J Biol Chem. 2002;277:37977-86 pubmed
    ..Immunogold electron microscopy confirmed the localization of SMOC-1 within basement membranes in kidney and skeletal muscle as well as its expression in the zona pellucida surrounding the oocyte. ..
  2. Okada I, Hamanoue H, Terada K, Tohma T, Megarbane A, Chouery E, et al. SMOC1 is essential for ocular and limb development in humans and mice. Am J Hum Genet. 2011;88:30-41 pubmed publisher mutations in the SPARC (secreted protein acidic and rich in cysteine)-related modular calcium binding 1 (SMOC1) in three families...
  3. Abouzeid H, Boisset G, Favez T, Youssef M, Marzouk I, Shakankiry N, et al. Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome. Am J Hum Genet. 2011;88:92-8 pubmed publisher
    ..23 locus, whose two affected children have a homozygous mutation in SMOC1. Knockdown experiments of the zebrafish smoc1 revealed that smoc1 is important in eye development and that it is ..
  4. Zhang G, Zhong Q, Gou X, Fan E, Shuai Y, Wu M, et al. Seven genes for the prognostic prediction in patients with glioma. Clin Transl Oncol. 2019;: pubmed publisher
    ..We identified a novel seven-gene signature associated with glioma. Among them, AL118505.1 and SMOC1 were positively related to the 5-year OS of patients with glioma, showing a better prognosis for glioma; however, ..
  5. Awwad K, Hu J, Shi L, Mangels N, Abdel Malik R, Zippel N, et al. Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis. Cardiovasc Res. 2015;106:284-94 pubmed publisher
    Secreted modular calcium-binding protein 1 (SMOC1) is a matricellular protein that potentially interferes with growth factor receptor signalling...
  6. Suzuki H, Yamamoto E, Yamano H, Nakase H, Sugai T. Integrated Analysis of the Endoscopic, Pathological and Molecular Characteristics of Colorectal Tumorigenesis. Digestion. 2019;99:33-38 pubmed publisher
    ..we detected methylation of secreted protein acidic and rich in cysteine (SPARC)-related modular calcium binding 1 (SMOC1) in traditional serrated adenomas (TSAs)...
  7. DeGroot M, Shi H, Eastman A, McKillop A, Liu J. The Caenorhabditis elegans SMOC-1 Protein Acts Cell Nonautonomously To Promote Bone Morphogenetic Protein Signaling. Genetics. 2019;211:683-702 pubmed publisher
    ..We further established that SMOC-1 functions cell nonautonomously to regulate body size. Human SMOC1 and SMOC2 can each partially rescue the smoc-1(0) mutant phenotype, suggesting that SMOC-1's function in ..
  8. Mancini C, Zonta A, Botta G, Klobus A, Valbonesi S, Pasini B, et al. A fetal case of microphthalmia and limb anomalies with abnormal neuronal migration associated with SMOC1 biallelic variants. Eur J Med Genet. 2018;: pubmed publisher
    ..with limb anomalies (MLA, OMIM, 206920) is a rare autosomal-recessive disease caused by recessive mutations in the SMOC1 gene...
  9. Slavotinek A. Genetics of anophthalmia and microphthalmia. Part 2: Syndromes associated with anophthalmia-microphthalmia. Hum Genet. 2018;: pubmed publisher
    ..Protein 4 (BMP4), Bone Morphogenetic Protein 7 (BMP7) and SPARC-related modular calcium-binding protein 1 (SMOC1)], genes involved in the mitochondrial respiratory chain complex [Holocytochrome c-type synthase (HCCS), ..

More Information


  1. Walline H, Komarck C, McHugh J, Bellile E, Brenner J, Prince M, et al. Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma. Mol Cancer Res. 2016;14:941-952 pubmed
    ..complex HPV integration patterns into cancer-associated genes, including TNFRSF13B, SCN2A, SH2B1, UBE2V2, SMOC1, NFIA, and SEMA6D Disrupted cellular transcripts were identified in the region of integration in four of the seven ..
  2. Fuller Carter P, Carter K, Anderson D, Harvey A, Giles K, Rodger J. Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration. BMC Genomics. 2015;16:591 pubmed publisher
    ..Gene ontology analysis placed the miRNA-regulated genes (eva1a, layna, nefmb, ina, si:ch211-51a6.2, smoc1, sb:cb252) in key biological processes that included cell survival/apoptosis, ECM-cytoskeleton signaling, and ..
  3. Chimusa E, Zaitlen N, Daya M, Möller M, van Helden P, Mulder N, et al. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. Hum Mol Genet. 2014;23:796-809 pubmed publisher
    ..This study provides insights into identifying disease genes and ancestry-specific disease risk in multi-way admixed populations. ..
  4. Zhang L, Choi H, Estrada K, Leo P, Li J, Pei Y, et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet. 2014;23:1923-33 pubmed publisher
    ..0 × 10(-8)) level: 14q24.2 (rs227425, P-value 3.98 × 10(-13), SMOC1) in the combined sample of males and females and 21q22.13 (rs170183, P-value 4...
  5. Wang B, Zhao X, Fan Y, Zhang J, Zhao J, Wang K. IL-17A but not IL-22 suppresses the replication of hepatitis B virus mediated by over-expression of MxA and OAS mRNA in the HepG2.2.15 cell line. Antiviral Res. 2013;97:285-92 pubmed publisher
    ..The expression of antiviral proteins, including myxovirus resistance A (MxA) and oligoadenylate synthetase (OAS), was enhanced by IL-17A. IL-22 and anti-human IL-22 receptor (IL-22R) antibody did not change any indexes...
  6. Lawrance Owen A, Bargary G, Bosten J, Goodbourn P, Hogg R, Mollon J. Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio. Hum Genet. 2013;132:415-21 pubmed publisher of 979 healthy adults, we find that digit ratio is strongly associated with variation upstream of SMOC1 (rs4902759: P = 1.41 × 10(-8)) and a meta-analysis of this and an independent study shows a probability of P = 1...
  7. Rainger J, van Beusekom E, Ramsay J, McKie L, Al Gazali L, Pallotta R, et al. Loss of the BMP antagonist, SMOC-1, causes Ophthalmo-acromelic (Waardenburg Anophthalmia) syndrome in humans and mice. PLoS Genet. 2011;7:e1002114 pubmed publisher
    ..2 identified homozygous mutations in SMOC1 (SPARC-related modular calcium binding 1) in eight unrelated families...
  8. Ullah A, Umair M, Ahmad F, Muhammad D, Basit S, Ahmad W. A novel homozygous variant in the SMOC1 gene underlying Waardenburg anophthalmia syndrome. Ophthalmic Genet. 2017;38:335-339 pubmed publisher
    ..1-q24.3 harboring the SMOC1 gene. Sequencing of the gene revealed a novel homozygous missense mutation (c.812G>A; p...
  9. Jamshidi J, Abdollahi S, Ghaedi H, Alehabib E, Tafakhori A, Alinaghi S, et al. A novel mutation in SMOC1 and variable phenotypic expression in two patients with Waardenburg anophthalmia syndrome. Eur J Med Genet. 2017;60:578-582 pubmed publisher
    ..Both patients were mentally normal. To detect the causative mutation all exons and exon-intron boundaries of SMOC1 gene were sequenced in patients and other normal family members...
  10. Brellier F, Ruggiero S, Zwolanek D, Martina E, Hess D, Brown Luedi M, et al. SMOC1 is a tenascin-C interacting protein over-expressed in brain tumors. Matrix Biol. 2011;30:225-33 pubmed publisher
    ..revealed phosphoglycerate kinase 1, clusterin, fibronectin, SPARC-related modular calcium-binding protein 1 (SMOC1) and nidogen-2 as potential interactors of tenascin-C...
  11. Sherva R, Miller M, Lynch A, Devereux R, Rao D, Oberman A, et al. A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study. Am J Hypertens. 2007;20:398-402 pubmed
    ..At least two chromosomal regions in humans are likely to harbor genes contributing to interindividual variation in PP/SV ratio, an index of arterial stiffness, in African Americans. ..
  12. Choi Y, Lim J, Kim K, Acharya B, Cho J, Bae Y, et al. Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation. J Proteome Res. 2010;9:2946-56 pubmed publisher
    ..profiles of BMSCs grown in osteogenic medium (OSM) and identified SPARC-related modular calcium-binding protein 1 (SMOC1), a member of the SPARC family, as a regulator of osteoblast differentiation of BMSCs...
  13. Thomas J, Chhuy Hy L, Andrykovich K, Moos M. SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR. PLoS ONE. 2016;11:e0154294 pubmed publisher
    ..SMOC does not appear to potentiate or inhibit MAPK signaling in response to pro-EGF, but the interaction could provide a mechanism for retaining soluble pro-EGF at the cell surface. ..