SMC3

Summary

Gene Symbol: SMC3
Description: structural maintenance of chromosomes 3
Alias: BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1, structural maintenance of chromosomes protein 3, SMC protein 3, basement membrane-associated chondroitin proteoglycan, chondroitin sulfate proteoglycan 6 (bamacan), chromosome-associated polypeptide
Species: human
Products:     SMC3

Top Publications

  1. Schmitz J, Watrin E, Lenart P, Mechtler K, Peters J. Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol. 2007;17:630-6 pubmed
    ..Our data indicate that sororin interacts with chromatin-bound cohesin and functions during the establishment or maintenance of cohesion in S or G2 phase, respectively. ..
  2. Kueng S, Hegemann B, Peters B, Lipp J, Schleiffer A, Mechtler K, et al. Wapl controls the dynamic association of cohesin with chromatin. Cell. 2006;127:955-67 pubmed
    ..Wapl depletion also increases the residence time of cohesin on chromatin in interphase. Our data indicate that Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin. ..
  3. Luo H, Li Y, Mu J, Zhang J, Tonaka T, Hamamori Y, et al. Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3. J Biol Chem. 2008;283:19176-83 pubmed publisher
    ..In the present work, we report that SMC3 is phosphorylated at Ser-1067 and Ser-1083 in vivo...
  4. Sumara I, Vorlaufer E, Gieffers C, Peters B, Peters J. Characterization of vertebrate cohesin complexes and their regulation in prophase. J Cell Biol. 2000;151:749-62 pubmed
    ..Both complexes contain SMC1, SMC3, SCC1, and either one of the yeast Scc3p orthologs SA1 and SA2. SA1 is also a subunit of 14S cohesin in Xenopus...
  5. Prieto I, Tease C, Pezzi N, Buesa J, Ortega S, Kremer L, et al. Cohesin component dynamics during meiotic prophase I in mammalian oocytes. Chromosome Res. 2004;12:197-213 pubmed
    ..In murine oocytes, SMC1beta, SMC3 and STAG3 are localized along fibers that correspond first to the chromosome axis and then to the synaptonemal ..
  6. Ghiselli G, Iozzo R. Overexpression of bamacan/SMC3 causes transformation. J Biol Chem. 2000;275:20235-8 pubmed
    ..assembled into basement membranes or as an intracellular protein known as structural maintenance of chromosome 3 (SMC3)...
  7. Strachan T. Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Curr Opin Genet Dev. 2005;15:258-64 pubmed
  8. Rankin S, Ayad N, Kirschner M. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell. 2005;18:185-200 pubmed
    ..We speculate that the protein, which we have named sororin, regulates the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes. ..
  9. Patel C, Ghiselli G. Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. BMC Cell Biol. 2005;6:3 pubmed
    The structural maintenance of chromosome proteins SMC1 and SMC3 play an important role in the maintenance of chromosomal integrity by preventing the premature separation of the sister chromatids at the onset of anaphase...

More Information

Publications89

  1. Lee J, Iwai T, Yokota T, Yamashita M. Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. J Cell Sci. 2003;116:2781-90 pubmed publisher
    ..transition by multisubunit protein complexes called cohesin, which include at least four proteins, SMC1alpha, SMC3, Rad21 and either SA1 or SA2, in mammalian somatic cells...
  2. Shimizu K, Shirataki H, Honda T, Minami S, Takai Y. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. J Biol Chem. 1998;273:6591-4 pubmed
    ..a subunit of condensins that regulate the assembly and structural maintenance of mitotic chromosomes, and named it HCAP (Human chromosome-associated polypeptide)...
  3. Hauf S, Roitinger E, Koch B, Dittrich C, Mechtler K, Peters J. Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol. 2005;3:e69 pubmed
    ..The similarity of the phenotype obtained after expression of nonphosphorylatable SA2 in human cells to that seen after the depletion of Plk1 suggests that SA2 is the critical target of Plk1 in the cohesin dissociation pathway. ..
  4. Zhang J, Shi X, Li Y, Kim B, Jia J, Huang Z, et al. Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell. 2008;31:143-51 pubmed publisher
    ..Here we report that yeast Eco1 and its human ortholog, ESCO1, both acetylate Smc3, a component of the cohesin complex that physically holds the sister chromatid together, at two conserved lysine ..
  5. Wendt K, Yoshida K, Itoh T, Bando M, Koch B, Schirghuber E, et al. Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature. 2008;451:796-801 pubmed publisher
    ..We propose that cohesin functions as a transcriptional insulator, and speculate that subtle deficiencies in this function contribute to 'cohesinopathies' such as Cornelia de Lange syndrome. ..
  6. Revenkova E, Focarelli M, Susani L, Paulis M, Bassi M, Mannini L, et al. Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA. Hum Mol Genet. 2009;18:418-27 pubmed publisher
    ..Mutations in the sister chromatid cohesion factor genes NIPBL, SMC1A and SMC3 are present in approximately 65% of CdLS patients...
  7. Losada A, Yokochi T, Hirano T. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. J Cell Sci. 2005;118:2133-41 pubmed
    ..This idea would explain why cells lacking Pds5 function display rather complex and diverse phenotypes in different organisms. ..
  8. Prieto I, Suja J, Pezzi N, Kremer L, Martinez A C, Rufas J, et al. Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I. Nat Cell Biol. 2001;3:761-6 pubmed
    ..STAG3 interacts with the structural maintenance chromosome proteins SMC1 and SMC3, which have been reported to be subunits of the mitotic cohesin complex...
  9. Ghiselli G, Liu C. Global gene expression profiling of cells overexpressing SMC3. Mol Cancer. 2005;4:34 pubmed
    The Structural Maintenance of Chromosome 3 protein (SMC3) plays an essential role during the sister chromatid separation, is involved in DNA repair and recombination and participates in microtubule-mediated intracellular transport...
  10. Schmiesing J, Ball A, Gregson H, Alderton J, Zhou S, Yokomori K. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. Proc Natl Acad Sci U S A. 1998;95:12906-11 pubmed
    ..SMC proteins that form two distinct heterodimeric complexes in the cell, the human chromosome-associated protein (hCAP)-C and hCAP-E protein complex (hCAP-C/hCAP-E), and the human SMC1 (hSMC1) and hSMC3 protein complex (hSMC1/hSMC3)...
  11. Barber T, McManus K, Yuen K, Reis M, Parmigiani G, Shen D, et al. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A. 2008;105:3443-8 pubmed publisher
    ..These results suggest that defective sister chromatid cohesion as a result of somatic mutations may represent a major cause of chromosome instability in human cancers. ..
  12. Wong R, Blobel G. Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole. Proc Natl Acad Sci U S A. 2008;105:15441-5 pubmed publisher
    ..Imbalances in these assembly pathways caused formation of multipolar spindles. Our data suggest that cohesin's known bundling function for chromatids in mitotic and interphase cells extends to microtubules at the spindle pole. ..
  13. Watrin E, Peters J. The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J. 2009;28:2625-35 pubmed publisher
    ..Earlier work has shown that phosphorylation of the cohesin subunits Smc1 and Smc3 is required for the intra-S checkpoint, but Smc1/Smc3 are also subunits of a distinct recombination complex, RC-1...
  14. Bauerschmidt C, Arrichiello C, Burdak Rothkamm S, Woodcock M, Hill M, Stevens D, et al. Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin. Nucleic Acids Res. 2010;38:477-87 pubmed publisher
    ..Our results suggest that the cohesin complex contributes to cell survival by promoting the repair of radiation-induced DNA double-strand breaks in G2-phase cells in an ATM-dependent pathway. ..
  15. Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A, Bhaskara V, et al. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 2010;143:737-49 pubmed publisher
    ..The mechanism we describe here may therefore be widely conserved among different species...
  16. Watrin E, Schleiffer A, Tanaka K, Eisenhaber F, Nasmyth K, Peters J. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol. 2006;16:863-74 pubmed
    ..The finding that Caenorhabditis elegans MAU-2 is an ortholog of Scc4 further supports the notion that the Scc2-Scc4 complex is required for developmental processes in metazoans. ..
  17. Losada A, Yokochi T, Kobayashi R, Hirano T. Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes. J Cell Biol. 2000;150:405-16 pubmed
    ..These results shed light on the mechanism by which sister chromatid cohesion is partially dissolved in early mitosis, far before the onset of anaphase, in vertebrate cells. ..
  18. Couchman J, Kapoor R, Sthanam M, Wu R. Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix. J Biol Chem. 1996;271:9595-602 pubmed
    ..Both are, however, basement membrane components, although there are tissue-specific differences in their distribution. ..
  19. Gandhi R, Gillespie P, Hirano T. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol. 2006;16:2406-17 pubmed
    ..Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits. ..
  20. Kim S, Xu B, Kastan M. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 2002;16:560-70 pubmed
    ..Protein complexes containing heterodimers of the Smc1 and Smc3 proteins have been implicated specifically in both sister chromatid cohesion and DNA recombination...
  21. Revenkova E, Eijpe M, Heyting C, Gross B, Jessberger R. Novel meiosis-specific isoform of mammalian SMC1. Mol Cell Biol. 2001;21:6984-98 pubmed
    ..Structural maintenance of chromosomes (SMC) proteins fulfill pivotal roles in chromosome dynamics. In yeast, the SMC1-SMC3 heterodimer is required for meiotic sister chromatid cohesion and DNA recombination...
  22. Deardorff M, Kaur M, Yaeger D, Rampuria A, Korolev S, Pie J, et al. Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation. Am J Hum Genet. 2007;80:485-94 pubmed
    ..report the identification of a mutation in the gene encoding the complementary subunit of the cohesin heterodimer, SMC3, and 14 additional SMC1A mutations...
  23. Ghiselli G, Coffee N, Munnery C, Koratkar R, Siracusa L. The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J Biol Chem. 2003;278:20259-67 pubmed
    The structural maintenance of chromosome protein SMC3 is a component of the cohesin complex that mediates sister chromatid cohesion and segregation in prokaryotes and eukaryotes...
  24. Haering C, L we J, Hochwagen A, Nasmyth K. Molecular architecture of SMC proteins and the yeast cohesin complex. Mol Cell. 2002;9:773-88 pubmed
    Sister chromatids are held together by the multisubunit cohesin complex, which contains two SMC (Smc1 and Smc3) and two non-SMC (Scc1 and Scc3) proteins...
  25. Wu N, Kong X, Ji Z, Zeng W, Potts P, Yokomori K, et al. Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Genes Dev. 2012;26:1473-85 pubmed publisher
    ..Expression of the acetylation-mimicking Smc3 mutant does not bypass the requirement for Mms21 in SCR...
  26. Lee J, Hwang S, Lee E. Imaging-based analysis of liposome internalization to macrophage cells: Effects of liposome size and surface modification with PEG moiety. Colloids Surf B Biointerfaces. 2015;136:786-90 pubmed publisher
    ..When the outside of the 200 nm liposomes was modified with biocompatible anchor molecule (BAM) consisting of PEG (ca. 2kD molecular weight) moiety, the endocytosis was indeed reduced by about 2...
  27. Carbonell A, Pérez Montero S, Climent Cantó P, Reina O, Azorín F. The Germline Linker Histone dBigH1 and the Translational Regulator Bam Form a Repressor Loop Essential for Male Germ Stem Cell Differentiation. Cell Rep. 2017;21:3178-3189 pubmed publisher
    ..Our results suggest that dBigH1 is a general silencing factor that represses Bam, a key regulator of spermatogonia proliferation that is silenced in spermatocytes...
  28. Kumar A, Kundu S, Debnath Das M. Expression, purification and evaluation of recombinant lipoprotein of Salmonella typhi as a vaccine candidate. Biologicals. 2017;46:108-113 pubmed publisher
    ..Lipoprotein gene (lp1) was cloned in pET32a expression vector in addition to Bam HI and Hind III restriction sites, and BL21(pLysS) was used as prokaryotic expression host for transformation...
  29. Williams A, Cooper W, Summage West C, Sims L, Woodruff R, Christman J, et al. Level 2 validation of a flow cytometric method for detection of Escherichia coli O157:H7 in raw spinach. Int J Food Microbiol. 2015;215:1-6 pubmed publisher
    The Bacteriological Analytical Manual (BAM) method currently used by the United States Food and Drug Administration (FDA) to detect Escherichia coli O157:H7 in spinach was systematically compared to a new flow cytometry based method...
  30. Shearer D, Sparkes W, Northeast J, Cunningham D, Cook C, Kilduff L. Measuring recovery: An adapted Brief Assessment of Mood (BAM+) compared to biochemical and power output alterations. J Sci Med Sport. 2017;20:512-517 pubmed publisher
    ..This study utilises a longitudinal multi-level design to test an adapted Brief Assessment of Mood (BAM+), with four extra items and a 100mm visual analogue scale to measure recovery...
  31. Todosijević M, Brezesinski G, Savić S, Neubert R. Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratumcorneum model lipids and Langmuir monolayers. Eur J Pharm Sci. 2017;99:161-172 pubmed publisher
    ..pressure-area (?-A) isotherms, infrared reflection-absorption spectroscopy (IRRAS), and Brewster angle microscopy (BAM), have been used to investigate interactions between SEs and SC intercellular lipids...
  32. Chen D, Zhou L, Sun F, Sun M, Tao X. Cyclin B3 Deficiency Impairs Germline Stem Cell Maintenance and Its Overexpression Delays Cystoblast Differentiation in Drosophila Ovary. Int J Mol Sci. 2018;19: pubmed publisher
    ..is not involved in Dad-mediated regulation of Bmp signaling, or required for dpp-induced bam transcriptional silencing...
  33. Moss J, Penhallow J, Ansari M, Barton S, Bourn D, Fitzpatrick D, et al. Genotype-phenotype correlations in Cornelia de Lange syndrome: Behavioral characteristics and changes with age. Am J Med Genet A. 2017;173:1566-1574 pubmed publisher
    ..Mutations in five genes that encode (SMC1A, SMC3, RAD21) or regulate (NIPBL, HDAC8) the cohesin complex have been identified in up to 70% of individuals...
  34. Akata K, Yatera K, Yamasaki K, Kawanami T, Naito K, Noguchi S, et al. The significance of oral streptococci in patients with pneumonia with risk factors for aspiration: the bacterial floral analysis of 16S ribosomal RNA gene using bronchoalveolar lavage fluid. BMC Pulm Med. 2016;16:79 pubmed publisher
    ..to cultivation methods in patients with community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP). Factors associated with aspiration risks in these patients were analyzed...
  35. Nakahara H, Hagimori M, Mukai T, Shibata O. Monolayers of a tetrazine-containing gemini amphiphile: Interplays with biomembrane lipids. Colloids Surf B Biointerfaces. 2018;164:1-10 pubmed publisher
    ..The phase behavior during monolayer compression was visualized with Brewster angle microscopy (BAM), fluorescence microscopy (FM), and atomic force microscopy (AFM)...
  36. Cheng Q, Huang W, Chen N, Shang Y, Zhang H. SMC3 may play an important role in atopic asthma development. Clin Respir J. 2016;10:469-76 pubmed publisher
    ..005252649). Further, SMC3 was detected as hot gene in PPI network, and NET (Elk3) was predicted as the significant transcription factor for ..
  37. Shapiro Kulnane L, Smolko A, SALZ H. Maintenance of Drosophila germline stem cell sexual identity in oogenesis and tumorigenesis. Development. 2015;142:1073-82 pubmed publisher
    ..and inappropriate Phf7 expression, is also observed in germ cell tumors arising from the loss of bag of marbles (bam), demonstrating that maintenance of female sexual identity requires the concerted actions of Sxl and bam...
  38. Batzenschlager M, Lermontova I, Schubert V, Fuchs J, Berr A, Koini M, et al. Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture. Proc Natl Acad Sci U S A. 2015;112:8656-60 pubmed publisher
    ..recruitment at the centromere of other proteins such as the CENP-C kinetochore component and the cohesin subunit SMC3 is impaired in gip1gip2...
  39. Fernandez P, Gabaldon J, Periago M. Detection and quantification of Alicyclobacillus acidoterrestris by electrical impedance in apple juice. Food Microbiol. 2017;68:34-40 pubmed publisher
    ..In addition, a positive correlation (r = 0.98, R2 = 0.97) was observed between the classical microbiology (BAM agar) and the indirect impedance method.
  40. Pappas M, Jolly S, Vijan S. Defining Appropriate Use of Proton-Pump Inhibitors Among Medical Inpatients. J Gen Intern Med. 2016;31:364-71 pubmed publisher
    ..Even in patients at particularly high risk of UGIB, only those at the very lowest risk of HCAP and CDI should be considered for prophylactic PPI use...
  41. Fu X, Xu L, Qi L, Tian H, Yi D, Yu Y, et al. BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cells. Oncol Rep. 2017;38:859-865 pubmed publisher
    ..In this study, we found that the nucleolar stress inducer BMH-21 inhibited viability of SKOV3 ovarian cancer cells in a dose-dependent manner...
  42. Nguyen T, Jagannathan M, Shire K, Frappier L. Interactions of the human MCM-BP protein with MCM complex components and Dbf4. PLoS ONE. 2012;7:e35931 pubmed publisher
    ..Since DDK is known to activate DNA replication through phosphorylation of these MCM proteins, our results suggest that MCM-BP may affect DNA replication in part by regulating MCM phosphorylation by DDK. ..
  43. Ma X, Han Y, Song X, Do T, Yang Z, Ni J, et al. DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation. Development. 2016;143:4312-4323 pubmed
    ..Finally, DNA damage also decreases the expression of the master differentiation factor Bam in a Lok-dependent manner, which helps explain the GSC progeny differentiation defect...
  44. Phan J, Wu P, Wang M. Improving the Flexibility of RNA-Seq Data Analysis Pipelines. IEEE Int Workshop Genomic Signal Process Stat. 2012;2012:70-73 pubmed
    ..the merging of transcriptome and reference genome mapping stages provided that they conform to the standard SAM/BAM format...
  45. Svensson D, Nebel D, Voss U, Ekblad E, Nilsson B. Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor ?. Cell Tissue Res. 2016;366:353-362 pubmed publisher
    ..CAMP mRNA several fold, and treatment with 1,25D3 for 24 h increased protein expression of the pro-form of LL-37 (hCAP-18) by about 13 times...
  46. Li Y, Liu W, Wang X, Zhu G, Wang C, Wang Y. A double substitution induced Ca(Mg0.8, Al0.2)(Si1.8, Al0.2)O6:Eu(2+) phosphor for w-LEDs: synthesis, structure, and luminescence properties. Dalton Trans. 2015;44:13196-203 pubmed publisher
    ..95% of that of the commercial BaMgAl10O17:Eu(2+) (BAM:Eu(2+)) phosphor and the quantum efficiency of the phosphor is 41.32%...
  47. Sun H, Resmini M, Zarbakhsh A. Interaction of thermal responsive NIPAM nanogels with model lipid monolayers at the air-water interface. J Colloid Interface Sci. 2018;519:97-106 pubmed publisher
    ..For a pure ceramide lipid monolayer, the neutron reflectivity (NR), Brewster angle microscopy (BAM) and surface pressure results showed a lipid-nanogel complex formation and the subsequent depletion/solubilisation ..
  48. Shi C, Chen W, Chen B, Shan T, Jia W, Hou X, et al. Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF. Biomater Sci. 2017;5:2427-2436 pubmed publisher
    ..In this study, the CBD-bFGF was used to activate a bladder acellular matrix (BAM) scaffold, and the CBD-bFGF/BAM functional scaffold was assessed in a canine model with a large segment defect (..
  49. Kubilay Z, Layon A, Baer H, Archibald L. When is pneumonia not pneumonia: a clinicopathologic study of the utility of lung tissue biopsies in determining the suitability of cadaveric tissue for donation. Cell Tissue Bank. 2016;17:205-10 pubmed publisher
    Healthcare-associated pneumonia (HCAP) represents a major diagnostic challenge because of the relatively low sensitivity and specificity of clinical criteria, radiological findings, and microbiologic culture results...
  50. Albers C, Feld L, Ellegaard Jensen L, Aamand J. Degradation of trace concentrations of the persistent groundwater pollutant 2,6-dichlorobenzamide (BAM) in bioaugmented rapid sand filters. Water Res. 2015;83:61-70 pubmed publisher
    ..for remediation of groundwater polluted by trace concentrations of the pesticide residue 2,6-dichlorobenzamide (BAM), we established a pilot waterworks including two sand filters. The waterworks treated groundwater polluted with 0...
  51. Rocha T, Gomes T, Durigon E, Bebianno M. Subcellular partitioning kinetics, metallothionein response and oxidative damage in the marine mussel Mytilus galloprovincialis exposed to cadmium-based quantum dots. Sci Total Environ. 2016;554-555:130-41 pubmed publisher
    ..directly associated with Cd in both forms, QDs subcellular partitioning is linked to biologically active metal (BAM), but no increase in LPO occurred, while in the case of dissolved Cd levels are in the biologically detoxified ..
  52. de Araújo F, Caseli L. Rhodanese incorporated in Langmuir and Langmuir-Blodgett films of dimyristoylphosphatidic acid: Physical chemical properties and improvement of the enzyme activity. Colloids Surf B Biointerfaces. 2016;141:59-64 pubmed publisher
    ..polarization-modulated infrared reflection-absorption spectroscopy (PM-IRRAS), and Brewster angle microscopy (BAM)...
  53. Hay I, Belousoff M, Dunstan R, Bamert R, Lithgow T. Structure and Membrane Topography of the Vibrio-Type Secretin Complex from the Type 2 Secretion System of Enteropathogenic Escherichia coli. J Bacteriol. 2018;200: pubmed publisher
    The β-barrel assembly machinery (BAM) complex is the core machinery for the assembly of β-barrel membrane proteins, and inhibition of BAM complex activity is lethal to bacteria...
  54. Canudas S, Houghtaling B, Kim J, Dynek J, Chang W, Smith S. Protein requirements for sister telomere association in human cells. EMBO J. 2007;26:4867-78 pubmed
    ..Our studies indicate that sister telomere association in human cells is mediated by a novel association between a cohesin subunit and components of telomeric chromatin. ..
  55. McCabe A, Ricci D, Adetunji M, Silhavy T. Conformational Changes That Coordinate the Activity of BamA and BamD Allowing ?-Barrel Assembly. J Bacteriol. 2017;199: pubmed publisher
    ..The ?-barrel assembly machine (Bam), a five-member complex composed of ?-barrel OMP BamA and four associated lipoproteins, BamB, BamC, BamD, and BamE, ..
  56. Corrado R, Lee D, Lucero D, Varma J, Vora N. Burden of Adult Community-acquired, Health-care-Associated, Hospital-Acquired, and Ventilator-Associated Pneumonia: New York City, 2010 to 2014. Chest. 2017;152:930-942 pubmed publisher
    ..was to estimate the burden of hospitalizations associated with community-acquired (CAP), health-care-associated (HCAP), hospital-acquired (HAP), and ventilator-associated (VAP) pneumonia from 2010 to 2014...
  57. Sowmiya C, Raja R, Cao J, Rajchakit G, Alsaedi A. Enhanced robust finite-time passivity for Markovian jumping discrete-time BAM neural networks with leakage delay. Adv Differ Equ. 2017;2017:318 pubmed publisher
    ..with the problem of enhanced results on robust finite-time passivity for uncertain discrete-time Markovian jumping BAM delayed neural networks with leakage delay...
  58. Liu M, Jevtic S, Markham Coultes K, Ellens N, O Reilly M, Hynynen K, et al. Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease. Brain Res. 2018;1678:138-145 pubmed publisher
    ..to transiently increase the blood-brain barrier (BBB) permeability and enhance the delivery of an Aβ-antibody (BAM-10), followed by scyllo-inositol treatment would result in accelerated clearance...
  59. Rizvi S, Usoh F, Hingorani A, Iadgarova E, Boniscavage P, Eisenberg J, et al. The Clinical Efficacy of Balloon-Assisted Maturation of Autogenous Arteriovenous Fistulae. Ann Vasc Surg. 2017;41:41-45 pubmed publisher
    ..Some have proposed that sequential balloon-assisted maturation (BAM) may accelerate the maturation times of these accesses...
  60. Ridinger H, Rutenberg C, Lutz D, Buness A, Petersen I, Amann K, et al. Expression and tissue localization of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 is modulated during rat and human left ventricular hypertrophy. Exp Mol Pathol. 2009;86:23-31 pubmed publisher
    ..Interestingly, intracellular translocation of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 (CSPG6/SMC3) was observed in the animal model and in LVH patients...
  61. Huber R, Kulemzina I, Ang K, Chavda A, Suranthran S, Teh J, et al. Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function. Structure. 2016;24:1991-1999 pubmed publisher
    The cohesin ring, which is composed of the Smc1, Smc3, and Scc1 subunits, topologically embraces two sister chromatids from S phase until anaphase to ensure their precise segregation to the daughter cells...
  62. Adams E, Champagne A, Williams J, Allen H. Interfacial properties of avian stratum corneum monolayers investigated by Brewster angle microscopy and vibrational sum frequency generation. Chem Phys Lipids. 2017;208:1-9 pubmed publisher
    ..Film properties were probed with surface pressure-area isotherms, Brewster angle microscopy (BAM), and vibrational sum frequency generation (VSFG)...
  63. Ouyang Z, Zheng G, Tomchick D, Luo X, Yu H. Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics. Mol Cell. 2016;62:248-259 pubmed publisher
    ..The IP6-binding segment of Pds5B is shaped like the jaw of a plier lever and inhibits the binding of Scc1 to Smc3. We propose that Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes.
  64. Horie H, Ito I, Konishi S, Yamamoto Y, Yamamoto Y, Uchida T, et al. Isolation of ESBL-producing Bacteria from Sputum in Community-acquired Pneumonia or Healthcare-associated Pneumonia Does Not Indicate the Need for Antibiotics with Activity against This Class. Intern Med. 2017;: pubmed publisher
    ..isolates. We identified patients with community-acquired pneumonia (CAP) or healthcare-associated pneumonia (HCAP) from whom ESBL-producing bacteria had been isolated from sputum culture and to whom antibiotic treatment had been ..
  65. Huis In t Veld P, Herzog F, Ladurner R, Davidson I, Piric S, Kreidl E, et al. Characterization of a DNA exit gate in the human cohesin ring. Science. 2014;346:968-72 pubmed publisher
    Chromosome segregation depends on sister chromatid cohesion mediated by cohesin. The cohesin subunits Smc1, Smc3, and Scc1 form tripartite rings that are thought to open at distinct sites to allow entry and exit of DNA...
  66. Ahn J, Lee K, Chung J, Shin K, Lee C, Kim H, et al. Clinical characteristics and prognostic risk factors of healthcare-associated pneumonia in a Korean tertiary teaching hospital. Medicine (Baltimore). 2017;96:e8243 pubmed publisher
    ..Diseases Society of America (ATS/IDSA) guidelines removed the concept of healthcare-associated pneumonia (HCAP). We examined whether the 2016?ATS/IDSA guidelines are applicable in Korea...
  67. Puthenveetil R, Kumar S, Caimano M, Dey A, Anand A, Vinogradova O, et al. The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola. Sci Rep. 2017;7:13260 pubmed publisher
    ..Collectively, our data suggest that MOSP destined for the TDE OM follows the canonical BAM pathway, while formation of a stable periplasmic conformer involves an export-related, folding pathway not present ..
  68. Ward A, Hopkins J, McKay M, Murray S, Jordan P. Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L. G3 (Bethesda). 2016;6:1713-24 pubmed publisher
    ..cohesin complexes consist of two structural maintenance of chromosomes proteins (SMC1α/SMC1β and SMC3), an α-kleisin protein (RAD21, RAD21L, or REC8), and a stromal antigen protein (STAG1, 2, or 3)...
  69. James R, Schmiesing J, Peters A, Yokomori K, Disteche C. Differential association of SMC1alpha and SMC3 proteins with meiotic chromosomes in wild-type and SPO11-deficient male mice. Chromosome Res. 2002;10:549-60 pubmed
    ..We determined that SMC1alpha and SMC3 localized to wild-type mouse meiotic chromosomes, but with distinct differences in their patterns...
  70. Li S, Yue Z, Tanaka T. Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase. Mol Cell. 2017;68:605-614.e4 pubmed publisher
    ..During this process, cohesin Smc3 undergoes a cycle of acetylation: Smc3 acetylation by Eco1 in S phase stabilizes cohesin association with ..
  71. Banerji R, Skibbens R, Iovine M. Cohesin mediates Esco2-dependent transcriptional regulation in a zebrafish regenerating fin model of Roberts Syndrome. Biol Open. 2017;6:1802-1813 pubmed publisher
    ..CdLS arises due to autosomal dominant mutations or haploinsufficiencies in cohesin subunits (SMC1A, SMC3 and RAD21) or cohesin auxiliary factors (NIPBL and HDAC8) that result in transcriptional ..
  72. Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek K, et al. Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications. Blood. 2014;123:914-20 pubmed publisher
    ..this study, we analyzed the frequency, clinical, and prognostic implications of mutations in STAG1, STAG2, SMC1A, SMC3, and RAD21, all members of the cohesin complex, in a cohort of 389 uniformly treated AML patients by next ..
  73. Thota S, Viny A, Makishima H, Spitzer B, Radivoyevitch T, Przychodzen B, et al. Genetic alterations of the cohesin complex genes in myeloid malignancies. Blood. 2014;124:1790-8 pubmed publisher
    ..Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2, SMC3, and RAD21 mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal ..
  74. Deardorff M, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, et al. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature. 2012;489:313-7 pubmed publisher
    ..for nearly 60% of individuals with classical CdLS, and by mutations in the core cohesin components SMC1A (~5%) and SMC3 (<1%) for a smaller fraction of probands...
  75. Kerminen K, Le Moël R, Harju V, Kontro M. Influence of organic matter, nutrients, and cyclodextrin on microbial and chemical herbicide and degradate dissipation in subsurface sediment slurries. Sci Total Environ. 2018;618:1449-1458 pubmed publisher
    ..additions enhance atrazine, simazine, hexazinone, dichlobenil, and the degradate 2,6-dichlorobenzamide (BAM) dissipations in sediment slurries under aerobic and anaerobic conditions, with sterilized controls...
  76. de Araújo Lima L, Wang K. PennCNV in whole-genome sequencing data. BMC Bioinformatics. 2017;18:383 pubmed publisher
    ..the performance of PennCNV original algorithm for array data in whole genome sequencing data, we processed mapping (BAM) files to extract coverage, representing log R ratio (LRR) of signal intensity, and B allele frequency (BAF)...
  77. Konovalova A, KAHNE D, Silhavy T. Outer Membrane Biogenesis. Annu Rev Microbiol. 2017;71:539-556 pubmed publisher
    ..transmembrane proteins assume a ?-barrel structure, and their assembly is catalyzed by the heteropentameric Bam complex containing the outer membrane protein BamA and four lipoproteins, BamB-E...
  78. Voges J, Ostermann J, Hernaez M. CALQ: compression of quality values of aligned sequencing data. Bioinformatics. 2017;: pubmed publisher
    ..schemes have been proposed for the coding of such data present in the form of raw FASTQ files and aligned SAM/BAM files...
  79. Ghiselli G. SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells. Mol Cancer. 2006;5:52 pubmed
    The structural maintenance of chromosome 3 (SMC3) protein is a constituent of a number of nuclear multimeric protein complexes that are involved in DNA recombination and repair in addition to chromosomal segregation...
  80. Terret M, Sherwood R, Rahman S, Qin J, Jallepalli P. Cohesin acetylation speeds the replication fork. Nature. 2009;462:231-4 pubmed publisher
    ..and restart activity of replication forks in human cells and is required for robust acetylation of cohesin's SMC3 subunit and sister chromatid cohesion...