SMARCAL1

Summary

Gene Symbol: SMARCAL1
Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
Alias: HARP, HHARP, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, ATP-driven annealing helicase, HepA-related protein, SMARCA-like protein 1, sucrose nonfermenting protein 2-like 1
Species: human
Products:     SMARCAL1

Top Publications

  1. Clewing J, Fryssira H, Goodman D, Smithson S, Sloan E, Lou S, et al. Schimke immunoosseous dysplasia: suggestions of genetic diversity. Hum Mutat. 2007;28:273-83 pubmed
    ..nonfermenting (swi/snf) related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1) are the only identified cause of SIOD...
  2. Yusufzai T, Kadonaga J. HARP is an ATP-driven annealing helicase. Science. 2008;322:748-50 pubmed publisher
    ..Mutations in the HepA-related protein (HARP) ATPase are responsible for Schimke immuno-osseous dysplasia (SIOD), but the function of the protein is unknown...
  3. Boerkoel C, Takashima H, John J, Yan J, Stankiewicz P, Rosenbarker L, et al. Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia. Nat Genet. 2002;30:215-20 pubmed
    ..Using genome-wide linkage mapping and a positional candidate approach, we determined that mutations in SMARCAL1 (SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), are ..
  4. Bokenkamp A, deJong M, van Wijk J, Block D, van Hagen J, Ludwig M. R561C missense mutation in the SMARCAL1 gene associated with mild Schimke immuno-osseous dysplasia. Pediatr Nephrol. 2005;20:1724-8 pubmed
    ..glomerulosclerosis (FSGS), T-cell immunodeficiency and facial dysmorphism is caused by defects in the SMARCAL1 gene. The gene product is involved in the transcriptional regulation of other genes...
  5. Bansbach C, Betous R, Lovejoy C, Glick G, Cortez D. The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev. 2009;23:2405-14 pubmed publisher
    Mutations in SMARCAL1 (HARP) cause Schimke immunoosseous dysplasia (SIOD). The mechanistic basis for this disease is unknown. Using functional genomic screens, we identified SMARCAL1 as a genome maintenance protein...
  6. Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev. 2009;23:2394-9 pubmed publisher
    Mutations in HepA-related protein (HARP) are the only identified causes of Schimke immunoosseous dysplasia (SIOD). HARP has a unique annealing helicase activity in vitro, but the in vivo functional significance remains unknown...
  7. Bétous R, Mason A, Rambo R, Bansbach C, Badu Nkansah A, Sirbu B, et al. SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Genes Dev. 2012;26:151-62 pubmed publisher
    b>SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like1) maintains genome integrity during DNA replication. Here we investigated its mechanism of action...
  8. Muthuswami R, Truman P, Mesner L, Hockensmith J. A eukaryotic SWI2/SNF2 domain, an exquisite detector of double-stranded to single-stranded DNA transition elements. J Biol Chem. 2000;275:7648-55 pubmed
    ..Furthermore, this study provides a foundation for development of mechanisms to specifically target this class of DNA-dependent ATPases. ..
  9. Coleman M, Eisen J, Mohrenweiser H. Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse. Genomics. 2000;65:274-82 pubmed
    ..to the Escherichia coli RNA polymerase-binding protein HepA and named the human hepA-related protein (HHARP/SMARCAL1)...

More Information

Publications139 found, 100 shown here

  1. Zivicnjak M, Franke D, Zenker M, Hoyer J, Lücke T, Pape L, et al. SMARCAL1 mutations: a cause of prepubertal idiopathic steroid-resistant nephrotic syndrome. Pediatr Res. 2009;65:564-8 pubmed publisher
    ..Molecular genetic analysis revealed compound heterozygosity for a known and a new mutation in the SMARCAL1 gene...
  2. Ciccia A, Bredemeyer A, Sowa M, Terret M, Jallepalli P, Harper J, et al. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev. 2009;23:2415-25 pubmed publisher
    ..Here we report the identification of a new DNA damage response protein, SMARCAL1 (SWI/SNF-related, matrix associated, actin-dependent regulator of chromatin, subfamily a-like 1), which is a ..
  3. Yusufzai T, Kong X, Yokomori K, Kadonaga J. The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev. 2009;23:2400-4 pubmed publisher
    HepA-related protein (HARP) (also known as SMARCAL1) is an ATP-driven annealing helicase that catalyzes the formation of dsDNA from complementary Replication protein A (RPA)-bound ssDNA...
  4. Postow L, Woo E, Chait B, Funabiki H. Identification of SMARCAL1 as a component of the DNA damage response. J Biol Chem. 2009;284:35951-61 pubmed publisher
    b>SMARCAL1 (also known as HARP) is a SWI/SNF family protein with an ATPase activity stimulated by DNA containing both single-stranded and double-stranded regions...
  5. Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep. 2011;12:574-80 pubmed publisher
    Mutations in HepA-related protein (HARP, or SMARCAL1) cause Schimke immunoosseous dysplasia (SIOD)...
  6. Pölkki T, Korhonen A. The effectiveness of music on pain among preterm infants in the neonatal intensive care unit: a systematic review. JBI Libr Syst Rev. 2012;10:4600-4609 pubmed
    ..Live music comprised of a lullaby sang by the female voice with frame drum and an accompanying harp. The same music was played by a tape recorder...
  7. Chavez D, Greer B, Eichman B. The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression. J Biol Chem. 2018;293:8484-8494 pubmed publisher
    ..fork remodelers, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like 1 (SMARCAL1) and zinc finger RANBP2 type-containing 3 (ZRANB3) to provide insight into their nonredundant roles in DNA damage ..
  8. Nickel A, Wäber N, Gösringer M, Lechner M, Linne U, Toth U, et al. Minimal and RNA-free RNase P in Aquifex aeolicus. Proc Natl Acad Sci U S A. 2017;114:11121-11126 pubmed publisher
    ..Homologs of Aquifex RNase P (HARP) were identified in many Archaea and some Bacteria, of which all Archaea and most Bacteria also encode an RNA-based ..
  9. Warejko J, Tan W, Daga A, Schapiro D, Lawson J, Shril S, et al. Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome. Clin J Am Soc Nephrol. 2018;13:53-62 pubmed publisher
    ..Fifteen of these mutations were novel. NPHS1, PLCE1, NPHS2, and SMARCAL1 were the most common genes in which we detected a mutation...
  10. Diplas B, He X, Brosnan Cashman J, Liu H, Chen L, Wang Z, et al. The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. Nat Commun. 2018;9:2087 pubmed publisher
    ..Here we report the genetic landscape of TERTpWT-IDHWT glioblastoma and identify SMARCAL1 inactivating mutations as a novel genetic mechanism of ALT...
  11. Kononenko A, Ebersole T, Vasquez K, Mirkin S. Mechanisms of genetic instability caused by (CGG)n repeats in an experimental mammalian system. Nat Struct Mol Biol. 2018;25:669-676 pubmed publisher
    ..Inactivation of genes implicated in break-induced replication, including Pold3, Pold4, Rad52, Rad51, and Smarcal1, reduced the frequency of ganciclovir-resistant clones to the baseline level that was observed in the absence of (..
  12. Baradaran Heravi A, Balgi A, Zimmerman C, Choi K, Shidmoossavee F, Tan J, et al. Novel small molecules potentiate premature termination codon readthrough by aminoglycosides. Nucleic Acids Res. 2016;44:6583-98 pubmed publisher
    ..nonsense mutations, as well as in cells from rare genetic disease patients with nonsense mutations in the CLN2, SMARCAL1 and DMD genes...
  13. Blanken A, Hurtz S, Zarow C, Biado K, Honarpisheh H, Somme J, et al. Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI. Neuroimage Clin. 2017;15:56-61 pubmed publisher
    ..These results provide further validation for the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).
  14. Seersholm F, Pedersen M, Søe M, Shokry H, Mak S, Ruter A, et al. DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4,000 years ago. Nat Commun. 2016;7:13389 pubmed publisher
    ..Our results confirm that the species found in the fossil record, like harp seal and ringed seal, were a vital part of Inuit subsistence, but also add a new dimension with evidence that ..
  15. Ataloglou D, Dimou A, Zarpalas D, Daras P. Fast and Precise Hippocampus Segmentation Through Deep Convolutional Neural Network Ensembles and Transfer Learning. Neuroinformatics. 2019;: pubmed publisher
    ..In the EADC-ADNI HarP dataset, the correspondence between the method's output and the available ground truth manual tracings yielded a ..
  16. . Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III-rationale, trial design and baseline data. Nephrol Dial Transplant. 2017;32:2043-2051 pubmed publisher
  17. Hara K, Kinoshita K, Migita T, Murakami K, Shimizu K, Takeuchi K, et al. Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. EMBO Rep. 2019;: pubmed publisher
    ..hCAP-H binds to the concave surfaces of a harp-shaped HEAT-repeat domain of hCAP-G...
  18. Jaiswara R, Dong J, Robillard T. Revision of the genus Pseudolebinthus (Orthoptera, Gryllidae, Eneopterinae) with the description of a new species from Southeast Africa. Zootaxa. 2018;4521:265-274 pubmed publisher
    ..to southeast Africa and characterized by unique morphological features such as asymmetrical male forewings and harp veins shaped as elongated balloons...
  19. Platero C, Tobar M. Combining a Patch-based Approach with a Non-rigid Registration-based Label Fusion Method for the Hippocampal Segmentation in Alzheimer's Disease. Neuroinformatics. 2017;15:165-183 pubmed publisher
    ..The algorithm is trained with the Harmonized Hippocampal Protocol (HarP). The proposal is compared with FreeSurfer and other label fusion methods...
  20. Soisook P, Karapan S, Satasook C, Bates P. A new species of Murina (Mammalia: Chiroptera: Vespertilionidae) from peninsular Thailand. Zootaxa. 2013;3746:567-79 pubmed publisher
    A new species of Murina belonging to 'suilla-group' is described based on two specimens collected with harp traps in lowland evergreen forest in the southernmost part of peninsular Thailand...
  21. Malacaria E, Pugliese G, Honda M, Marabitti V, Aiello F, Spies M, et al. Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation. Nat Commun. 2019;10:1412 pubmed publisher
    ..Mechanistically, RAD52 binds to the stalled replication fork, promotes its occlusion and counteracts loading of SMARCAL1 in vitro and in vivo...
  22. Scheuermann J, Howansky A, Hansroul M, Léveillé S, Tanioka K, Zhao W. Towards Scintillator High Gain Avalanche Rushing Photoconductor Active Matrix Flat Panel Imager (SHARP-AMFPI): initial fabrication and characterization. Med Phys. 2017;: pubmed publisher
    ..This detector includes a layer of avalanche amorphous Selenium (a-Se) (HARP) as the photoconductor in an indirect detector to amplify the signal and reduce the effects of electronic noise to ..
  23. Moyle W, Bramble M, Jones C, Murfield J, Bowers B. "She Had a Smile on Her Face as Wide as the Great Australian Bite": A Qualitative Examination of Family Perceptions of a Therapeutic Robot and a Plush Toy. Gerontologist. 2017;: pubmed publisher
    ..In this study, we sought to explore family members' perceptions of the Japanese-developed baby harp seal, Paro (version 9), and a look-alike, nonrobotic Plush Toy, when used by their relative with dementia for 15 ..
  24. Haynes R, Judge P, Staplin N, Herrington W, Storey B, Bethel A, et al. Effects of Sacubitril/Valsartan Versus Irbesartan in Patients with Chronic Kidney Disease: A Randomised Double-Blind Trial. Circulation. 2018;: pubmed publisher
    ..b>Methods -UK HARP-III was a randomised double-blind trial which included 414 participants with an estimated glomerular filtration ..
  25. Yu W, Li F, Csorba G, Xu Z, Wang X, Guo W, et al. A revision of Kerivoula hardwickii and occurrence of K. furva (Chiroptera: Vespertilionidae) in China. Zootaxa. 2018;4461:45-56 pubmed publisher
    Although increased survey efforts using improved capture methods (particularly harp traps) have greatly expanded the quantity of Kerivoula specimens available in China, the understanding of the genus has been long constrained...
  26. Rivera Mulia J, Dimond A, Vera D, Trevilla García C, Sasaki T, Zimmerman J, et al. Allele-specific control of replication timing and genome organization during development. Genome Res. 2018;: pubmed publisher
    ..We also present HARP: a new computational tool for sorting SNPs in phased genomes to efficiently measure allele-specific genome-wide ..
  27. Takeda N, Tamura K, Mineguchi R, Ishikawa Y, Haraguchi Y, Shimizu T, et al. In situ cross-linked electrospun fiber scaffold of collagen for fabricating cell-dense muscle tissue. J Artif Organs. 2016;19:141-8 pubmed publisher
    ..tissue from myoblasts, we proposed the electrospun type I collagen microfiber scaffold of the string-shape like a harp. The microfibers were oriented in the same direction to allow the myoblasts to align, and were strung at low ..
  28. Bansal R, Arya V, Sethy R, Rakesh R, Muthuswami R. RecA-like domain 2 of DNA-dependent ATPase A domain, a SWI2/SNF2 protein, mediates conformational integrity and ATP hydrolysis. Biosci Rep. 2018;38: pubmed publisher
    ..These proteins are classified as SF2 helicases. SMARCAL1, a member of this protein family, is known to modulate both DNA repair and transcription by specifically ..
  29. Duchesne S, Valdivia F, Robitaille N, Mouiha A, Valdivia F, Bocchetta M, et al. Manual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project. Alzheimers Dement. 2015;11:161-74 pubmed publisher
    ..Alzheimer's Disease Consortium and Alzheimer's Disease Neuroimaging Initiative (EADC-ADNI) Harmonized Protocol (HarP)...
  30. Höbel S, Appeldoorn C, Gaillard P, Aigner A. Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma. Pharmaceuticals (Basel). 2011;4:1591-1606 pubmed
    ..Likewise, the growth factor pleiotrophin (PTN/HB-GAM/HARP) is overexpressed in glioblastoma and is rate limiting for tumor growth, thus representing an attractive target ..
  31. Elmaraezy A, Abushouk A, Kamel M, Negida A, Naser O. Should hand-assisted retroperitoneoscopic nephrectomy replace the standard laparoscopic technique for living donor nephrectomy? A meta-analysis. Int J Surg. 2017;40:83-90 pubmed publisher
    We performed this meta-analysis to compare hand-assisted retroperitoneoscopic (HARP) and traditional laparoscopic (TLS) techniques for living donor nephrectomy...
  32. Boccardi M, Bocchetta M, Morency F, Collins D, Nishikawa M, Ganzola R, et al. Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol. Alzheimers Dement. 2015;11:175-83 pubmed publisher
    ..European Alzheimer's Disease Consortium and Alzheimer's Disease Neuroimaging Initiative (ADNI) Harmonized Protocol (HarP) is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging (MRI) that can be used ..
  33. Apostolova L, Zarow C, Biado K, Hurtz S, Boccardi M, Somme J, et al. Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol. Alzheimers Dement. 2015;11:139-50 pubmed publisher
    ..Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP)...
  34. Soulen B, Venables B, Johnston D, Roberts A. Accumulation of PBDEs in stranded harp (Pagophilus groenlandicus) and hooded seals (Cystophora cristata) from the Northeastern United States. Mar Environ Res. 2018;138:96-101 pubmed publisher
    ..Most studies reporting accumulation of PBDEs in seals have focused on harbor and grey seals with few examining harp and hooded seals...
  35. Cao J, Ngai N, Duncanson L, Cheng J, Gliganic K, Chen Q. A comparison of both DENSE and feature tracking techniques with tagging for the cardiovascular magnetic resonance assessment of myocardial strain. J Cardiovasc Magn Reson. 2018;20:26 pubmed publisher
    ..Tagging images were analyzed using harmonic phase (HARP) and displacement encoding with stimulated echoes (DENSE) images using a proprietary program...
  36. Aharinejad S, Andrukhova O, Gmeiner M, Thomas A, Aliabadi A, Zuckermann A, et al. Donor serum SMARCAL1 concentrations predict primary graft dysfunction in cardiac transplantation. Circulation. 2009;120:S198-205 pubmed publisher
    ..A sensitive, specific, and easily measurable predictor in donors could facilitate PGD prevention. SMARCAL1 is a matrix-associated regulator of chromatin with helicase and ATPase activities, and its serum concentrations ..
  37. Duignan P, Van Bressem M, Baker J, Barbieri M, Colegrove K, De Guise S, et al. Phocine distemper virus: current knowledge and future directions. Viruses. 2014;6:5093-134 pubmed publisher
    ..In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring ..
  38. Calfee C, Delucchi K, Sinha P, Matthay M, Hackett J, Shankar Hari M, et al. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018;6:691-698 pubmed publisher
    ..b>HARP-2 was a multicentre, randomised controlled trial of simvastatin (80 mg) versus placebo done in general intensive ..
  39. Wehner G, Suever J, Haggerty C, Jing L, Powell D, Hamlet S, et al. Validation of in vivo 2D displacements from spiral cine DENSE at 3T. J Cardiovasc Magn Reson. 2015;17:5 pubmed publisher
    ..variability of strains and torsion quantified by DENSE and agreement between DENSE and harmonic phase (HARP) were assessed by Bland-Altman analyses...
  40. Bocchetta M, Boccardi M, Ganzola R, Apostolova L, Preboske G, Wolf D, et al. Harmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project. Alzheimers Dement. 2015;11:151-60.e5 pubmed publisher
    A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging ..
  41. Gong Z, Chen J. E3 ligase RFWD3 participates in replication checkpoint control. J Biol Chem. 2011;286:22308-13 pubmed publisher
    ..Taken together, our results suggest that RFWD3 and RPA2 functionally interact and participate in replication checkpoint control. ..
  42. Sanyal M, Morimoto M, Baradaran Heravi A, Choi K, Kambham N, Jensen K, et al. Lack of IL7Rα expression in T cells is a hallmark of T-cell immunodeficiency in Schimke immuno-osseous dysplasia (SIOD). Clin Immunol. 2015;161:355-65 pubmed publisher
    ..This disease is linked to biallelic loss-of-function mutations of the SMARCAL1 gene...
  43. Shirazi A, Naderi M, Hassanpour H, Heidari M, Borjian S, Sarvari A, et al. The effect of ovine oocyte vitrification on expression of subset of genes involved in epigenetic modifications during oocyte maturation and early embryo development. Theriogenology. 2016;86:2136-2146 pubmed publisher
    ..involved in epigenetic modification (HAT1, HDAC1, SUV39H1, DNMT1, and DNMT3b), chromatin remodeling (HMGN3a and SMARCAL1), and transcription (STAT3), were investigated in fresh and vitrified germinal vesicle and metaphase II oocytes ..
  44. Wahba R, Kleinert R, Hellmich M, Kurschat C, Heiermann N, Dieplinger G, et al. Postoperative Continuous Infusion of Local Anesthesia in Hand-Assisted Retroperitoneoscopic Living Donor Nephrectomy. Transplant Proc. 2016;48:1940-3 pubmed publisher
    ..the dose of opioids in living kidney donors operated with hand-assisted retroperitoneoscopic donor nephrectomy (HARP). An observational study on 30 living donors was performed...
  45. Wahba R, Kleinert R, Hellmich M, Heiermann N, Dieplinger G, Schlößer H, et al. Optimizing a living kidney donation program: transition to hand-assisted retroperitoneoscopic living donor nephrectomy and introduction of a passive polarizing three-dimensional display system. Surg Endosc. 2017;31:2577-2585 pubmed publisher
    ..Hand-assisted retroperitoneoscopic donor nephrectomy (HARP) is an alternative to the open anterior approach (AA) technique...
  46. Ibrahim E, Stojanovska J, Hassanein A, Duvernoy C, Croisille P, Pop Busui R, et al. Regional cardiac function analysis from tagged MRI images. Comparison of techniques: Harmonic-Phase (HARP) versus Sinusoidal-Modeling (SinMod) analysis. Magn Reson Imaging. 2018;54:271-282 pubmed publisher
    ..k-space-based analysis techniques showed to be much faster than image-based techniques, where harmonic-phase (HARP) and sine-wave modeling (SinMod) stand as two famous techniques of the former group, which are frequently used in ..
  47. Wang W, Song H, Wei M, Qiu Z, Wang C, Zhang Y, et al. [SMARCAL1 gene analysis of 2 Chinese Schimke immuno-osseous dysplasia children]. Zhonghua Er Ke Za Zhi. 2015;53:45-50 pubmed
    Schimke immuno-osseous dysplasia (SIOD), is an autosomal recessive inherited disease caused by SMARCAL1 (MIM:20606622) mutations, while in about half of the patients no any mutation in SMARCAL1 could be found...
  48. Dos Santos C, Blanc C, Elahouel R, Prescott M, Carpentier G, Ori A, et al. Proliferation and migration activities of fibroblast growth factor-2 in endothelial cells are modulated by its direct interaction with heparin affin regulatory peptide. Biochimie. 2014;107 Pt B:350-7 pubmed publisher
    ..Fibroblast growth factor-2 (FGF-2) and heparin affin regulatory peptide (HARP) are two heparin-binding growth factors and were described for their pro-angiogenic properties on human umbilical ..
  49. Ohyama Y, Ambale Venkatesh B, Chamera E, Shehata M, Corona Villalobos C, Zimmerman S, et al. Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension. Int J Cardiol. 2015;182:342-348 pubmed publisher
    ..is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients...
  50. Burnham D, Nijholt B, De Vlaminck I, Quan J, Yusufzai T, Dekker C. Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively. Nucleic Acids Res. 2017;45:4687-4695 pubmed publisher
    We investigate the mechanistic nature of the Snf2 family protein HARP, mutations of which are responsible for Schimke immuno-osseous dysplasia...
  51. Zandifar A, Fonov V, Pruessner J, Collins D. The EADC-ADNI harmonized protocol for hippocampal segmentation: A validation study. Neuroimage. 2018;181:142-148 pubmed publisher
    ..segmentation that is optimized for Alzheimer's research (known as the EADC-ADNI Harmonized Protocol (the HarP))...
  52. Pearson L, Liwanag H, Hammill M, Burns J. To each its own: Thermoregulatory strategy varies among neonatal polar phocids. Comp Biochem Physiol A Mol Integr Physiol. 2014;178:59-67 pubmed publisher
    ..thermogenesis (NST via uncoupling protein 1; UCP1), and muscle thermogenesis (via enzyme activity) in neonatal harp (Pagophilus groenlandicus), hooded (Cystophora cristata), and Weddell seals (Leptonychotes weddellii)...
  53. Dent E, Perez Zepeda M. Comparison of five indices for prediction of adverse outcomes in hospitalised Mexican older adults: a cohort study. Arch Gerontol Geriatr. 2015;60:89-95 pubmed publisher
    ..during the first 48h of ward admission, and included: Frailty Index (FI), Hospital Admission Risk Profile (HARP), Score Hospitalier d'Evaluation du Risque de Perte d'Autonomie (SHERPA), Acute Physiology and Chronic Health ..
  54. Badu Nkansah A, Mason A, Eichman B, Cortez D. Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3). J Biol Chem. 2016;291:8251-7 pubmed publisher
    ..Several enzymes including SMARCAL1, HLTF, and ZRANB3 catalyze these reactions...
  55. Kuetting D, Feisst A, Dabir D, Homsi R, Sprinkart A, Luetkens J, et al. Comparison of magnetic resonance feature tracking with CSPAMM HARP for the assessment of global and regional layer specific strain. Int J Cardiol. 2017;244:340-346 pubmed publisher
    ..8% and 18.1%) was poor. The FT algorithm allows for reliable assessment of midmyocardial strain, while underestimating epicardial and endocardial strain and delivering less reproducible results than the gold standard of tagging. ..
  56. Schneider D, Graham K, Croghan K, Novotny P, Parkinson J, Lafky V, et al. Application of therapeutic harp sounds for quality of life among hospitalized patients. J Pain Symptom Manage. 2015;49:836-45 pubmed publisher
    ..The objective of the study was to assess the efficacy of prescriptive live therapeutic harp sounds on patient symptoms and QOL...
  57. Bhat K, Bétous R, Cortez D. High-affinity DNA-binding domains of replication protein A (RPA) direct SMARCAL1-dependent replication fork remodeling. J Biol Chem. 2015;290:4110-7 pubmed publisher
    b>SMARCAL1 catalyzes replication fork remodeling to maintain genome stability. It is recruited to replication forks via an interaction with replication protein A (RPA), the major ssDNA-binding protein in eukaryotic cells...
  58. Gutierrez D, Fahlman A, Gardner M, Kleinhenz D, Piscitelli M, Raverty S, et al. Phosphatidylcholine composition of pulmonary surfactant from terrestrial and marine diving mammals. Respir Physiol Neurobiol. 2015;211:29-36 pubmed publisher
    ..We found an increase in anti-adhesive PC species in harp seal (Pagophilus groenlandicus) and California sea lion (Zalophus californianus) compared to dog (Canus lupus ..
  59. Sills J, Southall B, Reichmuth C. Amphibious hearing in ringed seals (Pusa hispida): underwater audiograms, aerial audiograms and critical ratio measurements. J Exp Biol. 2015;218:2250-9 pubmed publisher
    ..Phoca largha) and harbor seals (Phoca vitulina), and considerably better than previously reported for ringed and harp seals. Best sensitivity was 49 dB re. 1 µPa (12.8 kHz) in water, and -12 dB re...
  60. Gupta M, Mazumder M, Dhatchinamoorthy K, Nongkhlaw M, Haokip D, Gourinath S, et al. Ligand-induced conformation changes drive ATP hydrolysis and function in SMARCAL1. FEBS J. 2015;282:3841-59 pubmed publisher
    Mutations and deletions in SMARCAL1, an SWI2/SNF2 protein, cause Schimke immuno-osseous dysplasia (SIOD)...
  61. Grimaldi D, Durand A, Gleeson J, Taccone F. Failure of statins in ARDS: the quest for the Holy Grail continues. Minerva Anestesiol. 2016;82:1230-1234 pubmed
    ..In the second study (HARP-2 trial), 540 patients with ARDS were randomized within 48-hours of onset to receive either simvastatin (80 mg/day) ..
  62. Poole L, Cortez D. Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability. Crit Rev Biochem Mol Biol. 2017;52:696-714 pubmed publisher
    ..b>SMARCAL1, ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome ..
  63. Liu S, Zhang M, Ni M, Zhu P, Xia X. A novel compound heterozygous mutation of the SMARCAL1 gene leading to mild Schimke immune-osseous dysplasia: a case report. BMC Pediatr. 2017;17:217 pubmed publisher
    ..b>SMARCAL1 gene mutations are determined in approximately 50% of patients diagnosed with SIOD...
  64. Liu H, Yan M, Song E, Wang J, Wang Q, Jin R, et al. Myocardial motion estimation of tagged cardiac magnetic resonance images using tag motion constraints and multi-level b-splines interpolation. Magn Reson Imaging. 2016;34:579-95 pubmed publisher
    ..Currently, the harmonic phase analysis method (HARP) and the local sine-wave modeling method (SinMod) have been proven as two state-of-the-art motion estimation ..
  65. Levsen A, Paoletti M, Cipriani P, Nascetti G, Mattiucci S. Species composition and infection dynamics of ascaridoid nematodes in Barents Sea capelin (Mallotus villosus) reflecting trophic position of fish host. Parasitol Res. 2016;115:4281-4291 pubmed
    ..the Barents Sea, and represents a critical food source for many predators in the area including Atlantic cod and harp seal. In Norway, the fish is of economic importance since whole capelin and roe are valuable export products...
  66. Sonne C, Andersen Ranberg E, Rajala E, Agerholm J, Bonefeld Jørgensen E, Desforges J, et al. Seroprevalence for Brucella spp. in Baltic ringed seals (Phoca hispida) and East Greenland harp (Pagophilus groenlandicus) and hooded (Cystophora cristata) seals. Vet Immunol Immunopathol. 2018;198:14-18 pubmed publisher
    ..Baltic ringed seals (Pusa hispida, n?=?12) sampled in October 2015 and Greenland Sea harp seals (Pagophilus groenlandicus, n?=?6) and hooded seals (Cystophora cristata, n?=?3) sampled in March 2015 were ..
  67. Barraza García J, Rivera Pedroza C, Belinchón A, Fernández Camblor C, Valenciano Fuente B, Lapunzina P, et al. A novel SMARCAL1 missense mutation that affects splicing in a severely affected Schimke immunoosseous dysplasia patient. Eur J Med Genet. 2016;59:363-6 pubmed publisher
    ..1615c > g, 1615_1644del; (p.[Leu539_Ile548del]), results in the loss of 10 amino acids of the HARP-ATPase catalytic domain and the RPA-binding domain...
  68. Chivers B, Béthoux O, Sarria S F, Jonsson T, Mason A, Montealegre Z F. Functional morphology of tegmina-based stridulation in the relict species Cyphoderris monstrosa (Orthoptera: Ensifera: Prophalangopsidae). J Exp Biol. 2017;220:1112-1121 pubmed publisher
    ..The wing cells widely involved in sound production, such as the harp and mirror, are comparatively small, poorly delimited and/or partially filled with cross-veins...
  69. Betous R, Glick G, Zhao R, Cortez D. Identification and characterization of SMARCAL1 protein complexes. PLoS ONE. 2013;8:e63149 pubmed publisher
    b>SMARCAL1 is an ATPase in the SNF2 family that functions at damaged replication forks to promote their stability and restart. It acts by translocating on DNA to catalyze DNA strand annealing, branch migration, and fork regression...
  70. Ying L, Wu L, Loke A. The effects of psychosocial interventions on the mental health, pregnancy rates, and marital function of infertile couples undergoing in vitro fertilization: a systematic review. J Assist Reprod Genet. 2016;33:689-701 pubmed publisher
    ..Integrative body-mind-spirit, and Mind/body intervention), cognitive behavioral therapy, group psychotherapy, and harp therapy...
  71. Platero C, Tobar M. A fast approach for hippocampal segmentation from T1-MRI for predicting progression in Alzheimer's disease from elderly controls. J Neurosci Methods. 2016;270:61-75 pubmed publisher
    ..this study, we investigate a combination of our method with annotations using the Harmonized Hippocampal Protocol (HarP)...
  72. Morimoto M, Myung C, Beirnes K, Choi K, Asakura Y, Bokenkamp A, et al. Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?. Orphanet J Rare Dis. 2016;11:149 pubmed
    ..mutations in the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin, subfamily A-like 1 (SMARCAL1) gene...
  73. Jacob A, Krishnamurthi G, Mathur M. Estimation of myocardial deformation using correlation image velocimetry. BMC Med Imaging. 2017;17:25 pubmed publisher
    ..The results were then compared with estimates from Harmonic Phase analysis (HARP) technique...
  74. Zhang D, Chen X, Yao H. SWAT-CS(enm): Enhancing SWAT nitrate module for a Canadian Shield catchment. Sci Total Environ. 2016;550:598-610 pubmed publisher
    ..SWAT-CS with an Enhanced Nitrate Module), and SWAT-CS were calibrated and tested with data of a subbasin of Harp Lake in south-central Ontario for 1990 to 2007...
  75. Zhou Y, Bernard O, Saloux E, Manrique A, Allain P, Makram Ebeid S, et al. 3D harmonic phase tracking with anatomical regularization. Med Image Anal. 2015;26:70-81 pubmed publisher
    This paper presents a novel algorithm that extends HARP to handle 3D tagged MRI images. HARP results were regularized by an original regularization framework defined in an anatomical space of coordinates...
  76. Liu S, Montgomery J, Yan Y, Mecchella J, Bartels S, Masutani R, et al. Association Between Hospital Admission Risk Profile Score and Skilled Nursing or Acute Rehabilitation Facility Discharges in Hospitalized Older Adults. J Am Geriatr Soc. 2016;64:2095-2100 pubmed publisher
    To evaluate whether the Hospital Admission Risk Profile (HARP) score is associated with skilled nursing or acute rehabilitation facility discharge after an acute hospitalization. Retrospective cohort study...
  77. Morgan A, Zhang Y, Tartibi M, Goldburg S, Kim J, Nguyen T, et al. Ischemic Mitral Regurgitation: Abnormal Strain Overestimates Nonviable Myocardium. Ann Thorac Surg. 2018;105:1754-1761 pubmed publisher
    ..16 ± 0.11 borderzone versus -0.18 ± 0.09 remote, p = 0.05). Impaired LV strain overestimates nonviable myocardium compared with TMI on LGE. Ischemia and infarct proximity also decrease strain in viable segments. ..
  78. Soulen B, Cammen K, Schultz T, Johnston D. Factors affecting harp seal (Pagophilus groenlandicus) strandings in the Northwest Atlantic. PLoS ONE. 2013;8:e68779 pubmed publisher
    ..Many high latitude species dependent on sea ice are being forced to adapt to changing habitats. Harp seals (Pagophilus groenlandicus) are an indicator species for changing high-latitude ecosystems...
  79. Morimoto M, Wang K, Yu Z, Gormley A, Parham D, Bogdanovic R, et al. Transcriptional and posttranscriptional mechanisms contribute to the dysregulation of elastogenesis in Schimke immuno-osseous dysplasia. Pediatr Res. 2015;78:609-17 pubmed publisher
    Schimke immuno-osseous dysplasia (SIOD) is an autosomal recessive disorder caused by mutations in SMARCAL1. A frequent complication is arteriosclerosis associated with reduced elastin expression; however, the mechanism underlying the ..
  80. Cranwell K, Polacsek M, McCann T. Mental health consumers' with medical co-morbidity experience of the transition through tertiary medical services to primary care. Int J Ment Health Nurs. 2016;25:127-35 pubmed publisher
    ..tertiary medical and primary care services; and (iv) Mental Health Hospital Admission Reduction Programme (MH HARP) clinicians facilitating transition...
  81. Chan S, Mallett A, Patel C, Francis R, Johnson D, Mudge D, et al. Recurrent atypical haemolytic uraemic syndrome post kidney transplant due to a CD46 mutation in the setting of SMARCAL1-mediated inherited kidney disease. Nephrology (Carlton). 2017;22 Suppl 1:11-14 pubmed publisher
    ..It highlights the complexity associated with disorders of complement regulation and the need for a high index of suspicion and genetic testing in patients who present with thrombotic microangiopathy post-transplant. ..
  82. Stark S, Somerville E, Keglovits M, Conte J, Li M, Hu Y, et al. Protocol for the home hazards removal program (HARP) study: a pragmatic, randomized clinical trial and implementation study. BMC Geriatr. 2017;17:90 pubmed publisher
    ..The goal of the Home Hazard Removal Program (HARP) study is to implement an evidence-based home modification intervention for older adults designed to reduce the ..
  83. Cai M, Brown E, Hatt A, Cheng S, Bilston L. Effect of head and jaw position on respiratory-related motion of the genioglossus. J Appl Physiol (1985). 2016;120:758-65 pubmed publisher
    ..Tissue displacement was quantified with harmonic phase (HARP) analysis...
  84. Frisoni G, Jack C, Bocchetta M, Bauer C, Frederiksen K, Liu Y, et al. The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity. Alzheimers Dement. 2015;11:111-25 pubmed publisher
    An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR...
  85. Terhune J, Bosker T. Harp Seals Do Not Increase Their Call Frequencies When It Gets Noisier. Adv Exp Med Biol. 2016;875:1149-53 pubmed publisher
    ..We addressed the hypothesis that Pagophilus groenlandicus (harp seals) will make more high-frequency underwater calls to avoid low-frequency conspecific masking as calling rates ..
  86. Buick A, Kennedy N, Carson R. Characteristics of corticospinal projections to the intrinsic hand muscles in skilled harpists. Neurosci Lett. 2016;612:87-91 pubmed publisher
    ..In the case of the harp, the demands placed on the motor system are quite specific...
  87. Lou S, Lamfers P, McGuire N, Boerkoel C. Longevity in Schimke immuno-osseous dysplasia. J Med Genet. 2002;39:922-5 pubmed
  88. Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell. 2012;47:410-21 pubmed publisher
    ..Interestingly, we identified a HARP-like (HPL) domain in AH2 that is indispensible for its annealing activity in vitro and its function in vivo...
  89. Couch F, Bansbach C, Driscoll R, Luzwick J, Glick G, Betous R, et al. ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev. 2013;27:1610-23 pubmed publisher
    ..Our data suggest that the DNA substrates of these nucleases are generated at least in part by the SMARCAL1 DNA translocase...
  90. Holsclaw J, Sekelsky J. Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1. Genetics. 2017;206:467-480 pubmed publisher
    ..We hypothesized that annealing during SDSA is performed by the annealing helicase SMARCAL1, which can anneal RPA-coated single DNA strands during replication-associated DNA damage repair...
  91. Simon A, Lev A, Jeison M, Borochowitz Z, Korn D, Lerenthal Y, et al. Novel SMARCAL1 bi-allelic mutations associated with a chromosomal breakage phenotype in a severe SIOD patient. J Clin Immunol. 2014;34:76-83 pubmed publisher
    ..Whole-exome sequencing revealed novel compound heterozygote mutations in SMARCAL1 gene, resulting in putative frame shifts of encoded SMARCAL1 from each allele and no detected protein in patient'..
  92. Rivera T, Haggblom C, Cosconati S, Karlseder J. A balance between elongation and trimming regulates telomere stability in stem cells. Nat Struct Mol Biol. 2017;24:30-39 pubmed publisher
    ..Thus, tight control of telomere length homeostasis is essential to maintain telomere stability in hESCs. ..