Smad1

Summary

Gene Symbol: Smad1
Description: SMAD family member 1
Alias: BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, mothers against decapentaplegic homolog 1, MAD, mothers against decapentaplegic homolog 1, Mad-related protein 1, SMAD, mothers against DPP homolog 1, TGF-beta signaling protein 1, mothers against DPP homolog 1, transforming growth factor-beta signaling protein 1
Species: human
Products:     Smad1

Top Publications

  1. Qiu T, Grizzle W, Oelschlager D, Shen X, Cao X. Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1. EMBO J. 2007;26:346-57 pubmed
    ..b>Smad1 acts as a substrate for MAPKs and also performs a central role in transmitting signals from BMPs...
  2. Nohe A, Keating E, Knaus P, Petersen N. Signal transduction of bone morphogenetic protein receptors. Cell Signal. 2004;16:291-9 pubmed
    ..This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways. ..
  3. Liu F, Hata A, Baker J, Doody J, Carcamo J, Harland R, et al. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature. 1996;381:620-3 pubmed
    ..We have cloned Smad1, a human homologue of Mad and Sma...
  4. Wotton D, Lo R, Lee S, Massague J. A Smad transcriptional corepressor. Cell. 1999;97:29-39 pubmed
    ..Formation of one of these two mutually exclusive complexes is determined by the relative levels of Smad corepressors and coactivators within the cell. ..
  5. Zhang Y, Chang C, Gehling D, Hemmati Brivanlou A, Derynck R. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2001;98:974-9 pubmed
    ..Smurf2 selectively interacts with receptor-regulated Smads and preferentially targets Smad1 for ubiquitination and proteasome-mediated degradation...
  6. Verschueren K, Remacle J, Collart C, Kraft H, Baker B, Tylzanowski P, et al. SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999;274:20489-98 pubmed
  7. Lin X, Liang M, Feng X. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J Biol Chem. 2000;275:36818-22 pubmed
    ..in vitro binding assays, we found that Smurf2 could interact with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3 but not Smad4...
  8. Kim R, Wang D, Tsang M, Martin J, Huff C, de Caestecker M, et al. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. Genes Dev. 2000;14:1605-16 pubmed
    ..The carboxyl terminus of SNIP1 interacts with Smad1 and Smad2 in yeast two-hybrid as well as in mammalian overexpression systems...
  9. Chen D, Zhao M, Mundy G. Bone morphogenetic proteins. Growth Factors. 2004;22:233-41 pubmed
    ..A. et al. (1996) "MADR1, a MAD-related protein that functions in BMP2 signaling pathways", Cell 85, 489-500; Chen Y. et al...

More Information

Publications85

  1. Knockaert M, Sapkota G, Alarcon C, Massague J, Brivanlou A. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc Natl Acad Sci U S A. 2006;103:11940-5 pubmed
    ..evidence identifying the SCP (small C-terminal domain phosphatase) family of nuclear phosphatases as mediators of Smad1 dephosphorylation in the BMP signaling pathway in vertebrates...
  2. Pannu J, Asano Y, Nakerakanti S, Smith E, Jablonska S, Blaszczyk M, et al. Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Arthritis Rheum. 2008;58:2528-37 pubmed publisher
    Activation of Smad1 signaling has recently been implicated in the development of fibrosis...
  3. Qin B, Chacko B, Lam S, de Caestecker M, Correia J, Lin K. Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol Cell. 2001;8:1303-12 pubmed
    Phosphorylation of Smad1 at the conserved carboxyl terminal SVS sequence activates BMP signaling...
  4. Lopez Rovira T, Chalaux E, Massague J, Rosa J, Ventura F. Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J Biol Chem. 2002;277:3176-85 pubmed
    ..These data suggest the simultaneous requirement of two independent DNA binding elements to allow functional cooperativity of BMP-regulated Smads and Smad4 in BMP-activated gene promoters. ..
  5. Aragón E, Goerner N, Zaromytidou A, Xi Q, Escobedo A, Massagué J, et al. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 2011;25:1275-88 pubmed publisher
    ..In the BMP pathway, Smad1 phosphorylation by CDK8/9 creates binding sites for the WW domains of YAP, and subsequent phosphorylation by GSK3 ..
  6. Wan M, Shi X, Feng X, Cao X. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. J Biol Chem. 2001;276:10119-25 pubmed
    ..Transfection of Smad1 and a constitutively active BMP type IA receptor ALK3 (Q233) stimulated the OPG promoter...
  7. Lee N, Haney J, Sogani J, Blobe G. Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling. FASEB J. 2009;23:3712-21 pubmed publisher
    ..The ALK-1/CK2beta interaction specifically enhanced Smad1/5/8 phosphorylation and ALK-1-mediated reporter activation in response to TGF-beta1 and BMP-9 treatment...
  8. Middlebrook B, Eldin K, Li X, Shivasankaran S, Pangas S. Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors. Endocrinology. 2009;150:5208-17 pubmed publisher
    ..The TGFbeta family is active in mouse Smad1-Smad5 double knockout tumors, and here we show that this pathway, but not the beta-catenin pathway, is activated ..
  9. Shi X, Yang X, Chen D, Chang Z, Cao X. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J Biol Chem. 1999;274:13711-7 pubmed
    ..Upon phosphorylation by the BMP receptors, Smad1 interacts with Smad4 and translocates into the nucleus where the complex recruits DNA-binding protein(s) to ..
  10. Herrera B, Van Dinther M, Ten Dijke P, Inman G. Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation. Cancer Res. 2009;69:9254-62 pubmed publisher
    ..ovarian surface epithelial cells and ovarian cancer cell lines, signaling predominantly through an ALK2/Smad1/Smad4 pathway rather than through ALK1, the major BMP9 receptor in endothelial cells...
  11. Massague J. TGF-beta signal transduction. Annu Rev Biochem. 1998;67:753-91 pubmed
    ..Mutations in these pathways are the cause of various forms of human cancer and developmental disorders. ..
  12. Macias Silva M, Hoodless P, Tang S, Buchwald M, Wrana J. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem. 1998;273:25628-36 pubmed
    ..BMP7 stimulated phosphorylation of endogenous Smad1 and 5, formation of complexes with Smad4 and induced the promoter for the homeobox gene, Tlx2...
  13. Lagna G, Hata A, Hemmati Brivanlou A, Massague J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature. 1996;383:832-6 pubmed
    ..b>Smad1 and Smad2 have been shown to mimic the effects of BMP and activin, respectively, both in Xenopus and in mammalian ..
  14. Wang L, Liu Y, Hao R, Chen L, Chang Z, Wang H, et al. Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem. 2011;286:15883-94 pubmed publisher
    ..superfamily of ligands signals along two intracellular pathways, Smad2/3-mediated TGF-β/activin pathway and Smad1/5/8-mediated bone morphogenetic protein pathway...
  15. Alarcon C, Zaromytidou A, Xi Q, Gao S, Yu J, Fujisawa S, et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell. 2009;139:757-69 pubmed publisher
    ..These phosphorylations promote Smad transcriptional action, which in the case of Smad1 is mediated by the recruitment of YAP to the phosphorylated linker sites...
  16. Nakerakanti S, Bujor A, Trojanowska M. CCN2 is required for the TGF-? induced activation of Smad1-Erk1/2 signaling network. PLoS ONE. 2011;6:e21911 pubmed publisher
    ..By depleting endogenous CCN2 we show that CCN2 is indispensable for the TGF-?-induced phosphorylation of Smad1 and Erk1/2, but it is unnecessary for the activation of Smad3...
  17. Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg A, et al. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell. 2011;44:721-33 pubmed publisher
    ..They further suggest that modulation of Cdh1 is a potential therapeutic option for treatment of osteoporosis. ..
  18. Wrighton K, Lin X, Yu P, Feng X. Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem. 2009;284:9755-63 pubmed publisher
    ..bone morphogenic protein (BMP) signaling is mediated via the ALK1/2/3/6 type I receptors that phosphorylate Smad1, Smad5, and Smad8 in their SXS motif...
  19. Sapkota G, Alarcon C, Spagnoli F, Brivanlou A, Massague J. Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell. 2007;25:441-54 pubmed
    ..BMP receptors signal through C-terminal phosphorylation and nuclear translocation of the transcription factor Smad1, whereas MAPKs catalyze inhibitory phosphorylation in the Smad1 linker region...
  20. Morris E, Chrobak I, Bujor A, Hant F, Mummery C, Ten Dijke P, et al. Endoglin promotes TGF-?/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol. 2011;226:3340-8 pubmed publisher
    ..TGF-? signaling is activated via elevated levels of activin receptor-like kinase (ALK) 1 and phosphorylated Smad1 (pSmad1)...
  21. Duan X, Liang Y, Feng X, Lin X. Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway. J Biol Chem. 2006;281:36526-32 pubmed
    ..A critical point of control in BMP signaling is the phosphorylation of Smad1, Smad5, and Smad8 in their C-terminal SXS motif...
  22. Hoodless P, Haerry T, Abdollah S, Stapleton M, O Connor M, Attisano L, et al. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell. 1996;85:489-500 pubmed
    ..We show that MAD functions downstream of DPP receptors and is required for receptor signaling. Phosphorylation of MADR1, a human homolog of MAD, is tightly regulated and rapidly induced by BMP2, but not TGF beta or activin...
  23. Abe H, Matsubara T, Iehara N, Nagai K, Takahashi T, Arai H, et al. Type IV collagen is transcriptionally regulated by Smad1 under advanced glycation end product (AGE) stimulation. J Biol Chem. 2004;279:14201-6 pubmed
    ..Here we identified this protein as Smad1 by yeast one-hybrid screening...
  24. Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, et al. CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol Cell Biol. 2004;24:856-64 pubmed
    ..Here we report a novel mechanism of the regulation of SMAD-mediated signaling, by which the Smad1 protein level is controlled through expression of the CHIP protein...
  25. Zhang Y, Feng X, We R, Derynck R. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 1996;383:168-72 pubmed
    ..These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor. ..
  26. Gruendler C, Lin Y, Farley J, Wang T. Proteasomal degradation of Smad1 induced by bone morphogenetic proteins. J Biol Chem. 2001;276:46533-43 pubmed
    ..b>Smad1 is one of the key signal transducers of BMPs and is responsible for transducing receptor activation signals from ..
  27. Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, et al. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science. 1999;284:479-82 pubmed
    ..p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 at its carboxyl terminus in a cytokine stimulation-dependent manner...
  28. Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, et al. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem. 2001;276:12477-80 pubmed
    ..These results thus reveal a novel function of Smad7, i.e. induction of degradation of TbetaR-I through recruitment of an E3 ligase to the receptor. ..
  29. Liu F, Massague J, Ruiz i Altaba A. Carboxy-terminally truncated Gli3 proteins associate with Smads. Nat Genet. 1998;20:325-6 pubmed
  30. Mu M, An P, Wu Q, Shen X, Shao D, Wang H, et al. The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression. J Nutr Biochem. 2016;30:53-61 pubmed publisher
    ..Treating cultured cells with myricetin decreased both HAMP mRNA levels and promoter activity by reducing SMAD1/5/8 phosphorylation...
  31. Arjunan P, Gnanaprakasam J, Ananth S, Romej M, Rajalakshmi V, Prasad P, et al. Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis. Invest Ophthalmol Vis Sci. 2016;57:1612-9 pubmed publisher
    ..Signaling of BMP6 was studied by the expression of Smad1/5/8 and pSmad4, and the BMP-target gene Id1. The interaction of pSmad4 with GPR91 promoter was studied by ChIP...
  32. Feng J, Gao J, Li Y, Yang Y, Dang L, Ye Y, et al. BMP4 enhances foam cell formation by BMPR-2/Smad1/5/8 signaling. Int J Mol Sci. 2014;15:5536-52 pubmed publisher
    ..Additionally, BMP4 treatment triggered the activation of Smad1/5/8 pathway by BMPR-2 signaling...
  33. Su D, Zhu S, Han X, Feng Y, Huang H, Ren G, et al. BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. J Biol Chem. 2009;284:12153-64 pubmed publisher
    ..Furthermore, our data revealed that p300 was recruited to P16(INK4a) and P21(WAF1/cip1) promoters by Smad1/5/8 to induce the hyperacetylation of histones H3 and H4 at the promoters...
  34. Hyung J, Ahn C, Je J. Blue mussel (Mytilus edulis) protein hydrolysate promotes mouse mesenchymal stem cell differentiation into osteoblasts through up-regulation of bone morphogenetic protein. Food Chem. 2018;242:156-161 pubmed publisher
    ..such as bone morphogenetic protein-2 (BMP-2), and downstream signal and transcription factors, including p-Smad1/5/8, Dlx5, runt-related transcription factor 2 (Runx2), and osterix...
  35. Willems B, Furmanik M, Caron M, Chatrou M, Kusters D, Welting T, et al. Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Sci Rep. 2018;8:4961 pubmed publisher
    ..mice showed increased mineralisation and expression of osteo/chondrogenic markers (BMP-2, Runx2, β-catenin, p-SMAD1/5/8, ALP, OCN), and decreased expression of mineralisation inhibitor MGP, suggesting that Ucma/GRP is an inhibitor ..
  36. Yun H, Ahn S, Park K, Kim M, Kim J, Jin G, et al. Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation. Biomaterials. 2016;85:88-98 pubmed publisher
    ..and nuclear factor-kappaB, as well as in the up-regulation of bone morphogenetic protein-2 and phosphorylation of Smad1/5/8...
  37. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, et al. BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nat Commun. 2017;8:13824 pubmed publisher
    ..b>Smad1/Smad4 recruits histone deacetylase HDAC1 to the promoters to repress transcription, and knockout of Smad4 ..
  38. Barruet E, Morales B, Lwin W, White M, Theodoris C, Kim H, et al. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 2016;7:115 pubmed publisher
    ..Finally, FOP iECs showed increased SMAD1/5/8 signaling upon BMP4 stimulation...
  39. Paarmann P, Dörpholz G, Fiebig J, Amsalem A, Ehrlich M, Henis Y, et al. Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling. Int J Biochem Cell Biol. 2016;76:51-63 pubmed publisher
    ..a role of dynamin2 in the regulation of steady-state and surface BMP receptor levels, as well as an impact on Smad1 protein level. Thus, dynamin2 allows for modulation of basal and ligand-dependent Smad signaling capacity...
  40. Yan X, Liao H, Cheng M, Shi X, Lin X, Feng X, et al. Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling. J Biol Chem. 2016;291:382-92 pubmed publisher
    ..These results shed new light on the regulation of TGF-β signaling by Smad7. ..
  41. Kuninty P, Bojmar L, Tjomsland V, Larsson M, Storm G, Östman A, et al. MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor. Oncotarget. 2016;7:16396-408 pubmed publisher
    ..Moreover, IPA analyses revealed signaling pathways related to miR-199a (TP53, mTOR, Smad1) and miR-214 (PTEN, Bax, ING4)...
  42. Yang J, Wu C, Stefănescu I, Jakobsson L, Chervoneva I, Horowitz A. RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms. Sci Signal. 2016;9:ra76 pubmed publisher
    ..whereas the differentiation-suppressing proteins SIRT1 (a protein deacetylase) and the phosphorylated form of SMAD1 (the active form of this transcription factor) were more abundant in cells of Syx(+/+) embryoid bodies...
  43. Aguilar O, Hadj Moussa H, Storey K. Regulation of SMAD transcription factors during freezing in the freeze tolerant wood frog, Rana sylvatica. Comp Biochem Physiol B Biochem Mol Biol. 2016;201:64-71 pubmed publisher
    ..Protein expression of Smad1/2/3/4/5 in response to freezing was examined in 24h frozen and 8h thawed wood frog tissues using western ..
  44. Kato Y, Habas R, Katsuyama Y, Naar A, He X. A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature. 2002;418:641-6 pubmed
    ..identified: TGF beta, Activin and Nodal signal via the Smad2 (or Smad3)-Smad4 complex, whereas BMP signals via the Smad1-Smad4 complex. How distinct Smad complexes regulate specific gene expression is not fully understood...
  45. Beauvais S, Drevelle O, Lauzon M, Daviau A, Faucheux N. Modulation of MAPK signalling by immobilized adhesive peptides: Effect on stem cell response to BMP-9-derived peptides. Acta Biomater. 2016;31:241-251 pubmed publisher
    ..BMP-9, pBMP-9 and SpBMP-9 induced greater phosphorylation of Smad1/5/8 in cells attached to PCL-pFibro than in cells on PCL-pBSP...
  46. Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, et al. The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling. Oncotarget. 2016;7:1120-43 pubmed publisher
    ..LKB1 protein expression and Smad1 phosphorylation analysis in a cohort of non-small cell lung cancer patients demonstrated a negative correlation ..
  47. Liu S, Tian Z, Yin F, Zhang P, W Y, Ding X, et al. Expression and functional roles of Smad1 and BMPR-IB in glioma development. Cancer Invest. 2009;27:734-40 pubmed publisher
    Here we report the negative correlation of phosphorylation of Smad1 and BMPR-IB expression with the development of human glioma...
  48. Ma X, Feng Y, Wang T, Lei W, Li X, Zhou D, et al. Involvement of FAK-mediated BMP-2/Smad pathway in mediating osteoblast adhesion and differentiation on nano-HA/chitosan composite coated titanium implant under diabetic conditions. Biomater Sci. 2017;6:225-238 pubmed publisher
    ..observation through inhibition of FAK phosphorylation, which contributed to suppressed BMP-2-dependent Smad1/5/8 phosphorylation...
  49. Mamo T, Wittern A, Kleppa M, Bohnenpoll T, Weiss A, Kispert A. BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. Hum Mol Genet. 2017;26:3553-3563 pubmed publisher
    ..Epithelial expression of P-ERK1/2, P-AKT and P-P38, and mesenchymal expression of P-SMAD1/5/9, P-P38 and P-AKT were abrogated...
  50. Shang X, Luo Z, Wang X, Jaeblon T, Marymont J, Dong Y. Deletion of RBPJK in Mesenchymal Stem Cells Enhances Osteogenic Activity by Up-Regulation of BMP Signaling. PLoS ONE. 2015;10:e0135971 pubmed publisher
    ..Additionally, BMP signaling responsive reporter activity and phosphor-smad1/5/8 expression were also significantly increased upon removal of RBPJK in MSCs...
  51. Alliston T, Ko T, Cao Y, Liang Y, Feng X, Chang C, et al. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005;280:24227-37 pubmed
    ..the highly conserved MH2 domain of Smad3, we investigated the physical and functional interaction of Evi-1 with Smad1 and Smad2, downstream targets of BMP and activin signaling, respectively...
  52. Braun D, Sadowski C, Kohl S, Lovric S, Astrinidis S, Pabst W, et al. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Nat Genet. 2016;48:457-65 pubmed publisher
    ..We hereby demonstrate that mutations of NUP genes cause a distinct renal disease and identify aberrant SMAD signaling as a new disease mechanism of SRNS, opening a potential new avenue for treatment. ..
  53. Hata A, Lagna G, Massague J, Hemmati Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998;12:186-97 pubmed
    Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription...
  54. Chiou J, Su C, Jan Y, Yang C, Huang M, Yu Y, et al. Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma. Sci Rep. 2017;7:9830 pubmed publisher
    Follistatin-related protein 1 (FSTL1) plays a critical role in lung development through regulating BMP4-p-Smad1/5/8-Smad4 pathway...
  55. Rodriguez C, Huang L, Son J, McKee A, Xiao Z, Lodish H. Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling. J Biol Chem. 2001;276:30224-30 pubmed
    ..BF-1 also associates with Smad1, -2, and -4; the Smad MH2 domain binds to BF-1, and the C-terminal segment of BF-1 is uniquely and solely required ..
  56. Li J, Ye L, Shi X, Chen J, Feng F, Chen Y, et al. Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer. Oncotarget. 2016;7:15678-89 pubmed publisher
    ..The tumor-suppressing effect of RGMB was exerted through inhibition of the Smad1/5/8 pathway...
  57. Frontelo P, Leader J, Yoo N, Potocki A, Crawford M, Kulik M, et al. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. Oncogene. 2004;23:5242-51 pubmed
    ..Thus, examination of the Smad-Suv interaction may provide insight into the mechanism of phenotypic determination mediated by BMP signaling. ..
  58. Schwappacher R, Weiske J, Heining E, Ezerski V, Marom B, Henis Y, et al. Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity. EMBO J. 2009;28:1537-50 pubmed publisher
    ..In the nucleus, cGKI binds with Smad1 and the general transcription factor TFII-I to promoters of BMP target genes such as Id1 to enhance ..
  59. Cummins T, Wu K, Bozatzi P, Dingwell K, MacArtney T, Wood N, et al. PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP. J Cell Sci. 2018;131: pubmed publisher
    Our previous studies of PAWS1 (protein associated with SMAD1; also known as FAM83G) have suggested that this molecule has roles beyond BMP signalling...
  60. Hata A, Seoane J, Lagna G, Montalvo E, Hemmati Brivanlou A, Massague J. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell. 2000;100:229-40 pubmed
    ..The mutually exclusive use of OAZ by the BMP-Smad and Olf pathways illustrates the dual role of a multi-zinc finger protein in signal transduction during development. ..
  61. Higgins D, Ewart L, Masterson E, Tennant S, Grebnev G, Prunotto M, et al. BMP7-induced-Pten inhibits Akt and prevents renal fibrosis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3095-3104 pubmed publisher
    ..In the kidney, collecting duct and tubular epithelial cells respond to BMP-7 via activation of SMAD1/5/8...
  62. Boeuf S, Bovee J, Lehner B, van den Akker B, van Ruler M, Cleton Jansen A, et al. BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors. BMC Cancer. 2012;12:488 pubmed publisher
    ..Expression of endoglin and nuclear localization of phosphorylated Smad1/5/8 and Smad2 was assessed by immunohistochemical analysis...
  63. Genthe J, Min J, Farmer D, Shelat A, Grenet J, Lin W, et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol. 2017;12:2436-2447 pubmed publisher
    ..a flavone that maximally activates the pathway after 24 h of treatment, all three ventromorphins induced SMAD1/5/8 phosphorylation within 30 min of treatment and achieved peak activity within 1 h, indicating that their ..
  64. Rani J, Mittal I, Pramanik A, Singh N, Dube N, Sharma S, et al. T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders. Sci Rep. 2017;7:6892 pubmed publisher
    ..A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued...
  65. Li Y, Tian L, Ligr M, Daniels G, Peng Y, Wu X, et al. Functional domains of androgen receptor coactivator p44/Mep50/WDR77and its interaction with Smad1. PLoS ONE. 2013;8:e64663 pubmed publisher
    ..Using a yeast two-hybrid screen, we identified a novel transcription complex AR-p44-Smad1, confirmed for physical interaction by co-immunoprecipitaion and functional interaction with luciferase assays in ..
  66. Xie Y, Shi W, Zhou J, Gao Y, Li S, Fang Q, et al. Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium. Bone. 2016;93:22-32 pubmed publisher
    ..differentiation and maturation of rat calvarial osteoblasts (ROBs) by activating bone morphogenetic protein BMP-Smad1/5/8 signaling on the condition that primary cilia were normal...
  67. Schwartze J, Becker S, Sakkas E, Wujak Ł, Niess G, Usemann J, et al. Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-? signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts. J Biol Chem. 2014;289:3262-75 pubmed publisher
    ..dexamethasone, methylprednisolone, budesonide, and fluticasone, potentiated TGF-? signaling by the Acvrl1/Smad1/5/8 signaling axis and blunted signaling by the Tgfbr1/Smad2/3 axis in NIH/3T3 cells, as well as primary lung ..
  68. Fukuda T, Kohda M, Kanomata K, Nojima J, Nakamura A, Kamizono J, et al. Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem. 2009;284:7149-56 pubmed publisher
    ..This mutant receptor, ALK2(R206H), activates BMP signaling without ligand binding. Moreover, expression of Smad1 and Smad5 was up-regulated in response to muscular injury...
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    ..Ectopic expression of AMSH prolongs BMP-induced Smad1 phosphorylation, and potentiates BMP-induced activation of transcriptional reporter activity, growth arrest and ..
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    ..levels of TGFβRII on the surface TGFβ activates not only its canonical Smad2/3-mediated signaling, but also Smad1/5-mediated signaling, what is rather typical for bone morphogenetic protein (BMP) stimulation...
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    ..we report that the co-repressor homeodomain-interacting protein kinase 2 (HIPK2) directly binds to both c-Ski and Smad1. HIPK2 efficiently inhibited Smad1/4-induced transcription from the Smad site-containing promoter...
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    ..Those included CTCL-upregulated BCL11A, SELL, IRF1, SMAD1, CASP1, BIRC5, and MAX and CTCL-downregulated MDM4, SERPINB3, and THBS4 genes...
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