Smad interacting protein 1


Gene Symbol: Smad interacting protein 1
Description: zinc finger E-box binding homeobox 2
Alias: HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B, zinc finger E-box-binding homeobox 2, SMAD interacting protein 1, Smad-interacting protein 1, zinc finger homeobox 1b
Species: human
Products:     Smad interacting protein 1

Top Publications

  1. Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell. 2001;7:1267-78 pubmed
    ..b>SIP1 (ZEB-2) is a Smad-interacting, multi-zinc finger protein that shows specific DNA binding activity...
  2. Koopmansch B, Berx G, Foidart J, Gilles C, Winkler R. Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression. Biochem Biophys Res Commun. 2013;431:652-7 pubmed publisher
    E-cadherin expression is repressed by ZEB2/SIP1 while it is induced by KLF4...
  3. Fang Y, Wei J, Cao J, Zhao H, Liao B, Qiu S, et al. Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival. PLoS ONE. 2013;8:e62558 pubmed publisher
    ..However, the expression status of ZEB2 in renal cell carcinoma (RCC) and ZEB2's clinicopathologic/prognostic significance are poorly understood...
  4. Espinosa Parrilla Y, Amiel J, Auge J, Encha Razavi F, Munnich A, Lyonnet S, et al. Expression of the SMADIP1 gene during early human development. Mech Dev. 2002;114:187-91 pubmed
    The smad binding protein 1 gene (SMADIP1, MIM 605802) has been recently identified as a disease causing gene in a polytopic embryonic defect (MIM 235730) including midline anomalies, facial dysmorphic features and enteric nervous system ..
  5. Maeda G, Chiba T, Okazaki M, Satoh T, Taya Y, Aoba T, et al. Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. Int J Oncol. 2005;27:1535-41 pubmed
    ..Among the repressors including SNAIL, SLUG, SIP1, E12 and E47, SIP1 was inversely correlated to E-cadherin (P < 0.05)...
  6. Chu P, Hu F, Yu C, Tsai L, Yu C, Wu B, et al. Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer. Oral Oncol. 2013;49:34-41 pubmed publisher
    ..Patients with tumors that co-expressed ZEB1(high) and ZEB2(high) had especially poor survival rates. Therapies targeting ZEB1/ZEB2 in HNC-CD133(+) cells may provide a new approach for HNC therapy in the future. ..
  7. Zweier C, Thiel C, Dufke A, Crow Y, Meinecke P, Suri M, et al. Clinical and mutational spectrum of Mowat-Wilson syndrome. Eur J Med Genet. 2005;48:97-111 pubmed
    ..with multiple malformations and a recognizable facial phenotype caused by defects of the transcriptional repressor ZFHX1B. To address the question of clinical and mutational variability, we analysed a large number of patients with ..
  8. Henrion M, Frampton M, Scelo G, Purdue M, Ye Y, Broderick P, et al. Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer. Hum Mol Genet. 2013;22:825-31 pubmed publisher
    ..Our findings suggest that genetic variation in ZEB2 influences the risk of RCC. This finding provides further insights into the genetic and biological basis of inherited genetic susceptibility to RCC...
  9. Renthal N, Chen C, Williams K, Gerard R, Prange Kiel J, Mendelson C. miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Proc Natl Acad Sci U S A. 2010;107:20828-33 pubmed publisher

More Information


  1. Gregory P, Bert A, Paterson E, Barry S, Tsykin A, Farshid G, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008;10:593-601 pubmed publisher
    ..cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis...
  2. Dastot Le Moal F, Wilson M, Mowat D, Collot N, Niel F, Goossens M. ZFHX1B mutations in patients with Mowat-Wilson syndrome. Hum Mutat. 2007;28:313-21 pubmed
    ..ZFHX1B encodes Smad-interacting protein-1 (SMADIP1 or SIP1), a transcriptional corepressor involved in the transforming growth factor-beta signaling pathway...
  3. Bassez G, Camand O, Cacheux V, Kobetz A, Dastot Le Moal F, Marchant D, et al. Pleiotropic and diverse expression of ZFHX1B gene transcripts during mouse and human development supports the various clinical manifestations of the "Mowat-Wilson" syndrome. Neurobiol Dis. 2004;15:240-50 pubmed
    b>ZFHX1B encodes Smad-interacting protein 1, a transcriptional corepressor involved in the transforming growth factors beta (TGFbeta) signaling pathway...
  4. Korpal M, Lee E, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008;283:14910-4 pubmed publisher
    ..These results suggested that loss of expression of the miR-200 family members may play a critical role in the repression of E-cadherin by ZEB1 and ZEB2 during EMT, thereby enhancing migration and invasion during cancer progression. ..
  5. Gregory P, Bracken C, Smith E, Bert A, Wright J, Roslan S, et al. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell. 2011;22:1686-98 pubmed publisher
  6. Postigo A, Depp J, Taylor J, Kroll K. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 2003;22:2453-62 pubmed
    ..The two members of the ZEB family of zinc finger factors (ZEB-1/deltaEF1 and ZEB-2/SIP1) regulate TGFbeta/BMP signaling in opposite ways: ZEB-1/deltaEF1 synergizes with Smad-mediated transcriptional ..
  7. Ishihara N, Yamada K, Yamada Y, Miura K, Kato J, Kuwabara N, et al. Clinical and molecular analysis of Mowat-Wilson syndrome associated with ZFHX1B mutations and deletions at 2q22-q24.1. J Med Genet. 2004;41:387-93 pubmed
  8. Qi S, Song Y, Peng Y, Wang H, Long H, Yu X, et al. ZEB2 mediates multiple pathways regulating cell proliferation, migration, invasion, and apoptosis in glioma. PLoS ONE. 2012;7:e38842 pubmed publisher
    ..Overexpression of ZEB2 is an unfavorable factor that may facilitate glioma progression. Knockdown ZEB2 expression by siRNA suppressed cell proliferation, migration, invasion and promoted cell apoptosis in glioma cells. ..
  9. Elloul S, Elstrand M, Nesland J, Trope C, Kvalheim G, Goldberg I, et al. Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer. 2005;103:1631-43 pubmed
    It was demonstrated previously that the Snail family of transcription factors and Smad-interacting protein 1 (Sip1) regulate E-cadherin and matrix metalloproteinase 2 (MMP-2) expression, cellular morphology, and invasion in carcinoma...
  10. Ohashi S, Natsuizaka M, Wong G, Michaylira C, Grugan K, Stairs D, et al. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res. 2010;70:4174-84 pubmed publisher
  11. Amiel J, Espinosa Parrilla Y, Steffann J, Gosset P, Pelet A, Prieur M, et al. Large-scale deletions and SMADIP1 truncating mutations in syndromic Hirschsprung disease with involvement of midline structures. Am J Hum Genet. 2001;69:1370-7 pubmed
    ..The SMADIP1 gene recently has been recognized as disease causing in some patients with 2q22 chromosomal rearrangement, ..
  12. Li A, Omura N, Hong S, Vincent A, Walter K, Griffith M, et al. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res. 2010;70:5226-37 pubmed publisher
    ..We also identified prevalent hypermethylation and silencing of one of their downstream targets, SIP1 (ZFHX1B, ZEB2), whose protein product suppresses E-cadherin expression and contributes to epithelial mesenchymal ..
  13. Garavelli L, Mainardi P. Mowat-Wilson syndrome. Orphanet J Rare Dis. 2007;2:42 pubmed heterozygous mutations or deletions in the Zinc finger E-box-binding homeobox 2 gene, ZEB2, previously called ZFHX1B (SIP1)...
  14. Postigo A. Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. EMBO J. 2003;22:2443-52 pubmed
    ..The two-handed zinc finger proteins encoded by Zfhx1a and Zfhx1b, ZEB-1/deltaEF1 and ZEB-2/SIP1, respectively, regulate gene expression and differentiation programs in a number of ..
  15. van Grunsven L, Michiels C, Van de Putte T, Nelles L, Wuytens G, Verschueren K, et al. Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin. J Biol Chem. 2003;278:26135-45 pubmed
    deltaEF1 and SIP1 (or Zfhx1a and Zfhx1b, respectively) are the only known members of the vertebrate Zfh1 family of homeodomain/zinc finger-containing proteins...
  16. Bracken C, Gregory P, Kolesnikoff N, Bert A, Wang J, Shannon M, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008;68:7846-54 pubmed publisher specifying the epithelial phenotype by preventing expression of the transcription repressors, ZEB1/deltaEF1 and SIP1/ZEB2. We show here that miR-200a, miR-200b, and the related miR-429 are all encoded on a 7...
  17. Lin S, Elledge S. Multiple tumor suppressor pathways negatively regulate telomerase. Cell. 2003;113:881-9 pubmed
    ..One, the Mad1/c-Myc pathway, had been previously implicated in hTERT regulation. The second, SIP1, a transcriptional target of the TGF-beta pathway, mediates the TGF-beta regulated repression of hTERT...
  18. Zweier C, Albrecht B, Mitulla B, Behrens R, Beese M, Gillessen Kaesbach G, et al. "Mowat-Wilson" syndrome with and without Hirschsprung disease is a distinct, recognizable multiple congenital anomalies-mental retardation syndrome caused by mutations in the zinc finger homeo box 1B gene. Am J Med Genet. 2002;108:177-81 pubmed
    Recently mutations in the gene ZFHX1B (SIP1) were shown in patients with "syndromic Hirschsprung disease" with mental retardation (MR) and multiple congenital anomalies (MCA), but it was unclear if Hirschsprung disease is an ..
  19. Yamada K, Yamada Y, Nomura N, Miura K, Wakako R, Hayakawa C, et al. Nonsense and frameshift mutations in ZFHX1B, encoding Smad-interacting protein 1, cause a complex developmental disorder with a great variety of clinical features. Am J Hum Genet. 2001;69:1178-85 pubmed
    Mutations in ZFHX1B, encoding Smad-interacting protein 1 (SIP1), have been recently reported to cause a form of Hirschsprung disease (HSCR)...
  20. Yoneda M, Fujita T, Yamada Y, Yamada K, Fujii A, Inagaki T, et al. Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B. Neurology. 2002;59:1637-40 pubmed
    ..retardation syndrome, a new 3-base pair deletion, eliminating an Asn, was identified in the responsible gene ZFHX1B. This suggests that screening for ZFHX1B mutations is warranted even in the absence of typical clinical features ..
  21. Cong N, Du P, Zhang A, Shen F, Su J, Pu P, et al. Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/?-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma. Oncol Rep. 2013;29:1579-87 pubmed publisher
    ..The effect of miR-200a on Wnt/?-catenin signaling may provide a therapeutic target against EMT. ..
  22. Mejlvang J, Kriajevska M, Vandewalle C, Chernova T, Sayan A, Berx G, et al. Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition. Mol Biol Cell. 2007;18:4615-24 pubmed
    Zinc finger transcription factors of the Snail/Slug and ZEB-1/SIP1 families control epithelial-mesenchymal transitions in development in cancer. Here, we studied SIP1-regulated mesenchymal conversion of epidermoid A431 cells...
  23. Mowat D, Wilson M, Goossens M. Mowat-Wilson syndrome. J Med Genet. 2003;40:305-10 pubmed
    ..The syndrome is the result of heterozygous deletions or truncating mutations of the ZFHX1B (SIP1) gene on chromosome 2q22.
  24. Verstappen G, van Grunsven L, Michiels C, Van de Putte T, Souopgui J, Van Damme J, et al. Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex. Hum Mol Genet. 2008;17:1175-83 pubmed publisher
    Mutations in ZFHX1B cause Mowat-Wilson syndrome (MWS) but the precise mechanisms underlying the aberrant functions of mutant ZFHX1B proteins (also named Smad-interacting protein-1, SIP1) in patients are unknown...
  25. Wu Q, Guo R, Lin M, Zhou B, Wang Y. MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2. Gynecol Oncol. 2011;122:149-54 pubmed publisher
    ..Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2, thereby enhancing migration and invasion in CD133/1+ cells. ..
  26. Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, et al. MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma. Ann Surg Oncol. 2012;19 Suppl 3:S656-64 pubmed publisher
    ..miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer. ..
  27. Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, et al. Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat Genet. 2001;27:369-70 pubmed
    ..Here we report that mutations in SIP1, encoding Smad interacting protein-1, cause disease in a series of cases...
  28. Verschueren K, Remacle J, Collart C, Kraft H, Baker B, Tylzanowski P, et al. SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999;274:20489-98 pubmed
    ..We describe a novel Smad-interacting protein, SIP1, which was identified using the yeast two-hybrid system...
  29. Miyoshi A, Kitajima Y, Sumi K, Sato K, Hagiwara A, Koga Y, et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer. 2004;90:1265-73 pubmed
    ..Recently, it has been reported that two transcription factors, Snail and SIP1 (Smad interacting protein 1), directly repress transcription of the E-cad gene by binding E-box on E-cad promoter...
  30. Acun T, Oztas E, Yagci T, Yakicier M. SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. BMC Cancer. 2011;11:223 pubmed publisher
    ..However, genetic and epigenetic alterations of SIP1 have not been fully elucidated in cancers...
  31. Nam E, Lee Y, Park Y, Lee J, Kim S. ZEB2 upregulates integrin ?5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells. Carcinogenesis. 2012;33:563-71 pubmed publisher
    ..These findings increase our understanding of the pathways beyond E-cadherin reduction that regulate mesenchymal gene expression during EMT and cancer progression. ..
  32. Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi J, et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A. 2007;104:3432-7 pubmed
    ..TGF-beta also decreased the expression of Smad-interacting protein 1 (SIP1), another E-box repressor similar to deltaEF1...
  33. Oztas E, Avci M, Ozcan A, Sayan A, Tulchinsky E, Yagci T. Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays. Exp Mol Pathol. 2010;89:182-9 pubmed publisher
    Smad-interacting protein 1 (SIP1, also known as ZEB2) represses the transcription of E-cadherin and mediates epithelial-mesenchymal transition in development and tumor metastasis...
  34. Zweier C, Temple I, Beemer F, Zackai E, Lerman Sagie T, Weschke B, et al. Characterisation of deletions of the ZFHX1B region and genotype-phenotype analysis in Mowat-Wilson syndrome. J Med Genet. 2003;40:601-5 pubmed
  35. Dai Y, Tang Y, Zhu H, Lv L, Chu Y, Zhou Y, et al. ZEB2 promotes the metastasis of gastric cancer and modulates epithelial mesenchymal transition of gastric cancer cells. Dig Dis Sci. 2012;57:1253-60 pubmed publisher
    ..ZEB2 promotes gastric cancer cell migration and invasion at least partly via the regulation of epithelial-mesenchymal transition. ZEB2 is a potential target for gene therapy of aggressive gastric cancer. ..
  36. Cai M, Luo R, Chen J, Pei X, Lu J, Hou J, et al. Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma. PLoS ONE. 2012;7:e32838 pubmed publisher
    ..The combined cytoplasmic ZEB2 prognostic model may become a useful tool for identifying patients with different clinical outcomes. ..
  37. Bindels S, Mestdagt M, Vandewalle C, Jacobs N, Volders L, Noel A, et al. Regulation of vimentin by SIP1 in human epithelial breast tumor cells. Oncogene. 2006;25:4975-85 pubmed
    The expression of Smad interacting protein-1 (SIP1; ZEB2) and the de novo expression of vimentin are frequently involved in epithelial-to-mesenchymal transitions (EMTs) under both normal and pathological conditions...
  38. Christoffersen N, Silahtaroglu A, Orom U, Kauppinen S, Lund A. miR-200b mediates post-transcriptional repression of ZFHX1B. RNA. 2007;13:1172-8 pubmed
    ..b>ZFHX1B is a transcriptional repressor involved in the TGFbeta signaling pathway and in processes of epithelial to ..
  39. Sayan A, Griffiths T, Pal R, Browne G, Ruddick A, Yagci T, et al. SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer. Proc Natl Acad Sci U S A. 2009;106:14884-9 pubmed publisher
    The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB family members, ZEB1 and ZEB2(SIP1), inhibit transcription of the E-cadherin gene and induce EMT in vitro...
  40. Nagaya M, Kato J, Niimi N, Tanaka S, Wakamatsu N. Clinical features of a form of Hirschsprung's disease caused by a novel genetic abnormality. J Pediatr Surg. 2002;37:1117-22 pubmed
    ..among the patients, exemplifying a newly recognized form of Hirschsprung's disease (HSCR) caused by mutations of ZFHX1B encoding Smad interacting protein-1...
  41. Wu X, Yan T, Wang Z, Wu X, Cao G, Zhang C. LncRNA ZEB2-AS1 promotes bladder cancer cell proliferation and inhibits apoptosis by regulating miR-27b. Biomed Pharmacother. 2017;96:299-304 pubmed publisher
    ..Our data provided strong evidence that ZEB2-AS1 promoted tumorigenesis and development of BC through down-regulating tumor-suppressive miR-27b. ..
  42. Zhang S, Jiang K, Yuan Z, Wang W. The single nucleotide polymorphisms in Smad-interacting protein 1 gene contribute to its ectopic expression and susceptibility in Hirschsprung's disease. Exp Mol Pathol. 2014;96:219-24 pubmed publisher
    ..It has been reported that the Smad-interacting protein 1(SIP1) is critical in embryonic development of ENS for its regulation on neural crest cells...
  43. Jacob S, Nayak S, Fernandes G, Barai R, Menon S, Chaudhari U, et al. Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer. Endocr Relat Cancer. 2014;21:473-86 pubmed publisher
    ..Thus, AR acts as a positive regulator of ZEB2 expression in androgen-dependent cells and as a negative regulator in AI PCa cells. ..
  44. Liang W, Fu W, Wong C, Wang Y, Wang W, Hu G, et al. The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. Oncotarget. 2015;6:22513-25 pubmed
  45. Wu L, Wang J, Conidi A, Zhao C, Wang H, Ford Z, et al. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016;19:1060-72 pubmed publisher
    ..Here we demonstrate that zinc-finger E-box-binding homeobox 2 (Zeb2, also called Sip1) transcription factor is a critical intrinsic timer that controls the onset of SC differentiation by recruiting ..
  46. Kumar P, Kotlyarevska K, Dejkhmaron P, Reddy G, Lu C, Bhojani M, et al. Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy. J Biol Chem. 2010;285:31148-56 pubmed publisher
    ..We speculate that the actions of GH on ZEB2 and P- and E-cadherin expression play a role in the pathogenesis of microalbuminuria of DN. ..
  47. Chandrashekarappa D, McCartney R, O Donnell A, Schmidt M. The ? subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress. Cell Signal. 2016;28:1881-1893 pubmed publisher
    Saccharomyces cerevisiae express three isoforms of Snf1 kinase that differ by which ? subunit is present, Gal83, Sip1 or Sip2...
  48. Jiang S, He X, Xia Y, Hu W, Luo J, Zhang J, et al. MicroRNA-145-5p inhibits gastric cancer invasiveness through targeting N-cadherin and ZEB2 to suppress epithelial-mesenchymal transition. Onco Targets Ther. 2016;9:2305-15 pubmed publisher
    ..ZEB2 acts as transcriptional repressor of E-cadherin, while miR-145-5p is known to suppress N-cadherin directly to regulate EMT. Therefore, we concluded that miR-145-5p may target N-cadherin and ZEB2 directly to influence EMT. ..
  49. Gherman C, Braicu O, Zanoaga O, Jurj A, Pileczki V, Maralani M, et al. Caffeic acid phenethyl ester activates pro-apoptotic and epithelial-mesenchymal transition-related genes in ovarian cancer cells A2780 and A2780cis. Mol Cell Biochem. 2016;413:189-98 pubmed publisher
    ..Overall data suggest that CAPE can be used as an alternative in sensitizing cells to chemotherapy. ..
  50. Xu M, Chen Z, Zhou Z, Zheng Y, Yuan Y, Zhang Q, et al. [Application of gene microarray to screen differential expression genes of Modic changes at vertebral endplates]. Zhonghua Yi Xue Za Zhi. 2015;95:2532-6 pubmed
    ..There are differentially expressed genes between lumbar endplate with Modic changes and without Modic changes.Modic changes may be multiple genes involved and regulated pathological changes. ..
  51. Galán Cobo A, Ramirez Lorca R, Serna A, Echevarria M. Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture. PLoS ONE. 2015;10:e0137692 pubmed publisher
    ..Larger expression of AQP3 may confer to the cell a more tumor like phenotype and contributes to explain the presence of this protein in many different tumors. ..
  52. Fadul J, Bell R, Hoffman L, Beckerle M, ENGEL M, Lessnick S. EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes Cancer. 2015;6:129-43 pubmed
  53. Kim C, Lee H, Gupta N, Ramachandran S, Kaushik I, Srivastava S, et al. Role of Forkhead Box Class O proteins in cancer progression and metastasis. Semin Cancer Biol. 2018;50:142-151 pubmed publisher
  54. Xu Y, Lee D, Feng Z, Xu Y, Bu W, Li Y, et al. Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice. Proc Natl Acad Sci U S A. 2017;114:11494-11499 pubmed publisher
    ..Therefore, Twist1 is required for the expression of other EMT-inducing TFs in a small subset of tumor cells. Together, they induce partial EMT, basal-like tumor progression, intravasation, and metastasis. ..
  55. Sun D, Wang J, Zhang P, Wang Y. MicroRNA-138 Regulates Metastatic Potential of Bladder Cancer Through ZEB2. Cell Physiol Biochem. 2015;37:2366-74 pubmed publisher
    ..Suppression of miR-138 in BC cells may promote ZEB2-mediated cancer invasion and metastases. Thus, miR-138 appears to be an intriguing therapeutic target to prevent metastases of BC. ..
  56. Zhou D, Wang X, Wang Y, Xiang X, Liang Z, Zhou Y, et al. MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt/?-catenin pathway. Mol Immunol. 2016;75:151-60 pubmed publisher
    ..Taken together, our results revealed the critical regulatory role of miR-145 in HSCs activation and implied miR-145 as a potential candidate for therapy of hepatic fibrosis by regulation of Wnt/?-catenin through targeting ZEB2. ..
  57. Weng Q, Chen Y, Wang H, Xu X, Yang B, He Q, et al. Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron. 2012;73:713-28 pubmed publisher
    ..opposing regulators of myelination are functionally linked by the Olig1/2 common target Smad-interacting protein-1 (Sip1). We demonstrate that Sip1 is an essential modulator of CNS myelination...
  58. Ang L, Zheng L, Wang J, Huang J, Hu H, Zou Q, et al. Expression of and correlation between BCL6 and ZEB family members in patients with breast cancer. Exp Ther Med. 2017;14:3985-3992 pubmed publisher
    ..These results suggest that BCL6, ZEB1 and ZEB2 are potential biomarkers for the invasion, metastasis and prognosis of breast cancer, and that BCL6 may be a regulator of the ZEB family...
  59. Qiu G, Lin Y, Zhang H, Wu D. miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2. Biochem Biophys Res Commun. 2015;463:315-21 pubmed publisher
    ..Our study indicates that miR-139-5p functions as a suppressor of HCC EMT and metastasis by targeting ZEB1 and ZEB2, and it may be a therapeutic target for metastatic HCC. ..
  60. Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt M, et al. Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2. Eur J Immunol. 2014;44:553-60 pubmed publisher
    ..Our results provide the first hint that the molecular EMT machinery might facilitate LC mobilization. Moreover, our study suggests that N-cadherin plays a role during DC migration. ..
  61. Jiang T, Dong P, Li L, Ma X, Xu P, Zhu H, et al. MicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells. Oncol Rep. 2017;38:151-158 pubmed publisher
    ..Our study further demonstrated that miR-200c could enhance the sensitivity of SGC7901/DDP cells to DDP through targeted regulation of ZEB2 expression in gastric cancer tissues. ..
  62. Yang T, Zhou H, Liu P, Yan L, Yao W, Chen K, et al. lncRNA PVT1 and its splicing variant function as competing endogenous RNA to regulate clear cell renal cell carcinoma progression. Oncotarget. 2017;8:85353-85367 pubmed publisher
    ..Our study helps reveal new molecular events in ccRCC and provides promising diagnostic and therapeutic targets for this disease...
  63. Sun Q, Dong M, Wang Z, Wang C, Sheng D, Li Z, et al. Selenium-enriched polysaccharides from Pyracantha fortuneana (Se-PFPs) inhibit the growth and invasive potential of ovarian cancer cells through inhibiting ?-catenin signaling. Oncotarget. 2016;7:28369-83 pubmed publisher
    ..These effects are achieved by the inhibition of ?-catenin signaling. Thus Se-PFPs can be used as potential therapeutic agents in the prevention and treatment of ovarian cancer. ..
  64. Kang J, Amar M, Remaley A, Kwon J, Blackshear P, Wang P, et al. Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J Immunol. 2011;187:2696-701 pubmed publisher
  65. Göppel J, Möckelmann N, Münscher A, Sauter G, Schumacher U. Expression of Epithelial-Mesenchymal Transition Regulating Transcription Factors in Head and Neck Squamous Cell Carcinomas. Anticancer Res. 2017;37:5435-5440 pubmed
    ..Twist is the major transcription factor active in HNSCC; the other transcription factors of EMT seem to be of less importance in this tumor entity. ..
  66. Sasongko T, Sadewa A, Gunadi -, Lee M, Koterazawa K, Nishio H. Nonsense mutations of the ZFHX1B gene in two Japanese girls with Mowat-Wilson syndrome. Kobe J Med Sci. 2007;53:157-62 pubmed
    ..a multiple congenital anomaly-mental retardation complex caused by mutations in the Zinc Finger Homeobox 1 B gene (ZFHX1B). MWS has been reported in association with Hirschsprung disease (HSCR)...