SLX4

Summary

Gene Symbol: SLX4
Description: SLX4 structure-specific endonuclease subunit
Alias: BTBD12, FANCP, MUS312, BTB (POZ) domain containing 12, BTB/POZ domain-containing protein 12, SLX4 structure-specific endonuclease subunit homolog, structure-specific endonuclease subunit SLX4
Species: human

Top Publications

  1. pmc Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    Jennifer M Svendsen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 138:63-77. 2009
  2. pmc Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
    Samira Fekairi
    Genome Instability and Carcinogenesis UPR3081 CNRS, Conventionné par l Université d Aix Marseille 2, IGC, IMM 31 chemin Joseph Aiguier, 13402 Marseille, France
    Cell 138:78-89. 2009
  3. doi Mutation analysis of the SLX4/FANCP gene in hereditary breast cancer
    Rosa Landwehr
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Breast Cancer Res Treat 130:1021-8. 2011
  4. doi Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair
    Ivan M Munoz
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Mol Cell 35:116-27. 2009
  5. doi Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases
    Janine L Bakker
    Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
    Hum Mutat 34:70-3. 2013
  6. doi The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4
    Bastian Salewsky
    Institute of Medical and Human Genetics, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Hum Mol Genet 21:4948-56. 2012
  7. pmc Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis
    Gargi Ghosal
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:34225-33. 2012
  8. pmc Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase
    Kseniya Zakharyevich
    Department of Microbiology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Cell 149:334-47. 2012
  9. pmc Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families
    Juana Fernández-Rodríguez
    Hereditary Cancer Program, Catalan Institute of Oncology ICO, Hospital Duran i Reynals, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet, Barcelona, Catalonia, Spain
    BMC Cancer 12:84. 2012
  10. pmc Sequencing analysis of SLX4/FANCP gene in Italian familial breast cancer cases
    Irene Catucci
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    PLoS ONE 7:e31038. 2012

Detail Information

Publications18

  1. pmc Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    Jennifer M Svendsen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 138:63-77. 2009
    ..Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312...
  2. pmc Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
    Samira Fekairi
    Genome Instability and Carcinogenesis UPR3081 CNRS, Conventionné par l Université d Aix Marseille 2, IGC, IMM 31 chemin Joseph Aiguier, 13402 Marseille, France
    Cell 138:78-89. 2009
    ..identification of Slx4 orthologs in metazoa, including fly MUS312, essential for meiotic recombination, and human BTBD12, an ATM/ATR checkpoint kinase substrate...
  3. doi Mutation analysis of the SLX4/FANCP gene in hereditary breast cancer
    Rosa Landwehr
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Breast Cancer Res Treat 130:1021-8. 2011
    b>SLX4 coordinates three structure-specific endonucleases in the DNA damage response. One subtype of Fanconi anaemia, FA-P, has recently been attributed to biallelic SLX4 gene mutations...
  4. doi Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair
    Ivan M Munoz
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Mol Cell 35:116-27. 2009
    Budding yeast Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion of ribosomal DNA replication...
  5. doi Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases
    Janine L Bakker
    Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
    Hum Mutat 34:70-3. 2013
    SLX4/FANCP is a recently discovered novel disease gene for Fanconi anemia (FA), a rare recessive disorder characterized by chromosomal instability and increased cancer susceptibility...
  6. doi The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4
    Bastian Salewsky
    Institute of Medical and Human Genetics, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Hum Mol Genet 21:4948-56. 2012
    ..expressed hSNM1B/Apollo co-immunoprecipitates with SLX4, a protein recently identified as a new FA protein, FANCP, and known to interact with several structure-specific nucleases...
  7. pmc Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis
    Gargi Ghosal
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:34225-33. 2012
    ..Thus, C1orf124 acts at multiple steps in TLS, stabilizes RAD18 and ubiquitinated PCNA at damage sites, and facilitates the switch from replicative to TLS polymerase to bypass DNA lesion...
  8. pmc Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase
    Kseniya Zakharyevich
    Department of Microbiology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Cell 149:334-47. 2012
    ..three distinct endonucleases capable of resolving JMs in vitro have been identified: Mus81-Mms4(EME1), Slx1-Slx4(BTBD12), and Yen1(GEN1)...
  9. pmc Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families
    Juana Fernández-Rodríguez
    Hereditary Cancer Program, Catalan Institute of Oncology ICO, Hospital Duran i Reynals, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet, Barcelona, Catalonia, Spain
    BMC Cancer 12:84. 2012
    ..Mutations in the SLX4 gene, which encodes for a scaffold protein involved in the repair of interstrand cross-links, have recently been ..
  10. pmc Sequencing analysis of SLX4/FANCP gene in Italian familial breast cancer cases
    Irene Catucci
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    PLoS ONE 7:e31038. 2012
    ..Very recently, SLX4 has been established as a new FA gene raising the question of its implication in breast cancer risk...
  11. pmc Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
    Yonghwan Kim
    Laboratory of Genome Maintenance, Rockefeller University, New York, NY 10065 6399, USA
    Blood 121:54-63. 2013
    SLX4, the newly identified Fanconi anemia protein, FANCP, is implicated in repairing DNA damage induced by DNA interstrand cross-linking (ICL) agents, topoisomerase I (TOP1) inhibitors, and in Holliday junction resolution...
  12. pmc Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes
    Erin K Schwartz
    Department of Microbiology, University of California Davis, Davis, CA 95616, USA
    Chromosoma 120:109-27. 2011
    ..of bacterial RuvC, leading to the discovery of a number of DNA endonucleases, including Mus81-Mms4/EME1, Slx1-Slx4/BTBD12/MUS312, XPF-ERCC1, and Yen1/GEN1...
  13. doi SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
    Chantal Stoepker
    Department of Clinical Genetics, Vrije Universiteit VU Medical Center, Amsterdam, The Netherlands
    Nat Genet 43:138-41. 2011
    ..b>SLX4, which coordinates three separate endonucleases, was recently recognized as an important regulator of DNA repair...
  14. pmc Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia
    Gerry P Crossan
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    Nat Genet 43:147-52. 2011
    ..Here we describe the phenotype of the Btbd12 knockout mouse, the mouse ortholog of SLX4, which recapitulates many key features of the human genetic illness ..
  15. pmc Mutations of the SLX4 gene in Fanconi anemia
    Yonghwan Kim
    Laboratory of Genome Maintenance, The Rockefeller University, New York, New York, USA
    Nat Genet 43:142-6. 2011
    ..anemia and show that the cellular defects in these individuals' cells are complemented by wildtype SLX4, demonstrating that biallelic mutations in SLX4 (renamed here as FANCP) cause a new subtype of Fanconi anemia, Fanconi anemia-P.
  16. pmc Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination
    Sabrina L Andersen
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell 35:128-35. 2009
    ..protein-protein interactions, and ICL repair function, we determined that the mammalian ortholog of MUS312 is BTBD12. Orthology between these proteins and S...
  17. pmc Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis
    J Kim Holloway
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    PLoS Genet 7:e1002094. 2011
    The mammalian ortholog of yeast Slx4, BTBD12, is an ATM substrate that functions as a scaffold for various DNA repair activities. Mutations of human BTBD12 have been reported in a new sub-type of Fanconi anemia patients...