SLURP1

Summary

Gene Symbol: SLURP1
Description: secreted LY6/PLAUR domain containing 1
Alias: ANUP, ARS, ArsB, LY6LS, MDM, secreted Ly-6/uPAR-related protein 1, ARS(component B)-81/S, SLURP-1, anti-neoplastic urinary protein, lymphocyte antigen 6-like secreted, secreted Ly6/uPAR related protein 1
Species: human
Products:     SLURP1

Top Publications

  1. Arredondo J, Chernyavsky A, Webber R, Grando S. Biological effects of SLURP-1 on human keratinocytes. J Invest Dermatol. 2005;125:1236-41 pubmed
    ..These results suggest that the biological role of SLURP-1 in the epidermis is to provide fine tuning of the physiologic regulation of KC functions through the cholinergic pathways. ..
  2. Chimienti F, Hogg R, Plantard L, Lehmann C, Brakch N, Fischer J, et al. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. Hum Mol Genet. 2003;12:3017-24 pubmed
    ..Mal de Meleda is an autosomal recessive inflammatory and keratotic palmoplantar skin disorder due to mutations in the ARS B gene, encoding for SLURP-1 (secreted mammalian Ly-6/uPAR-related protein 1)...
  3. Pettersson A, Nordlander S, Nylund G, Khorram Manesh A, Nordgren S, Delbro D. Expression of the endogenous, nicotinic acetylcholine receptor ligand, SLURP-1, in human colon cancer. Auton Autacoid Pharmacol. 2008;28:109-16 pubmed publisher
    ..4. The current findings suggest that SLURP-1 participates in the regulation of gut immune functions and motility, as well as possibly playing a role in colon carcinogenesis/cancer progression. ..
  4. Wajid M, Kurban M, Shimomura Y, Christiano A. Mutations in the SLURP-1 gene underlie Mal de Meleda in three Pakistani families. J Dermatol Sci. 2009;56:27-32 pubmed publisher
    Mal de Meleda (MDM) (MIM #248300) is an autosomal recessive palmoplantar keratoderma (PPK)...
  5. Tjiu J, Lin P, Wu W, Cheng Y, Chiu H, Thong H, et al. SLURP1 mutation-impaired T-cell activation in a family with mal de Meleda. Br J Dermatol. 2011;164:47-53 pubmed publisher
    ..Among the family members, patients with the homozygous SLURP1 (previously known as ARS component B) mutation are prone to melanoma and viral infection, which might link to ..
  6. Marrakchi S, Audebert S, Bouadjar B, Has C, Lefèvre C, Munro C, et al. Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda. J Invest Dermatol. 2003;120:351-5 pubmed
    ..Four ancestral haplotypes were observed in 69 patients from countries around the Mediterranean basin, and an additional haplotype was found in the German and Scottish patients. ..
  7. Fischer J, Bouadjar B, Heilig R, Huber M, Lefevre C, Jobard F, et al. Mutations in the gene encoding SLURP-1 in Mal de Meleda. Hum Mol Genet. 2001;10:875-80 pubmed
    ..described interval of MDM on chromosome 8qter, and the identification of mutations in affected individuals in the ARS (component B) gene, encoding a protein named SLURP-1, for secreted Ly-6/uPAR related protein 1...
  8. Eckl K, Stevens H, Lestringant G, Westenberger Treumann M, Traupe H, Hinz B, et al. Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. Hum Genet. 2003;112:50-6 pubmed
    ..Mutations in the ARS (component B)-81/s gene ( LY6LS) on chromosome 8q24-qter, which encodes SLURP-1, have recently been identified in patients with MDM...
  9. Charfeddine C, Mokni M, Ben Mousli R, Elkares R, Bouchlaka C, Boubaker S, et al. A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia. Br J Dermatol. 2003;149:1108-15 pubmed
    Mal de Meleda (MDM) is a rare autosomal recessive skin disorder which belongs to the clinically and genetically heterogeneous group of palmoplantar keratodermas (PPK)...

More Information

Publications140 found, 100 shown here

  1. Letsa T, Noora C, Kuma G, Asiedu E, Kye Duodu G, Afari E, et al. Pneumococcal meningitis outbreak and associated factors in six districts of Brong Ahafo region, Ghana, 2016. BMC Public Health. 2018;18:781 pubmed publisher
    ..Overall attack rate (AR) was 235.0/100,000 population. District specific ARs were; Tain; 143.6/100,000, Wenchi; 110.0/100,000, Techiman; 46.6/100,000, Jaman North; 382...
  2. Negreş S, Zanfirescu A, Ionică F, Moroşan E, Velescu B, Şeremet O, et al. Pharmacotoxicological screening on new derivatives of beta-phenylethylamine, potential agonists of beta3-adrenergic receptors. Rom J Morphol Embryol. 2016;57:969-978 pubmed
    Beta3-adrenergic receptors (beta3-ARs) have been initially characterized in 1989...
  3. Ramkumar H, Zhang J, Chan C. Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res. 2010;29:169-90 pubmed publisher
    ..Third, natural mouse strains such as arrd2/arrd2 (Mdm gene mutation) and the senescence accelerated mice (SAM) spontaneously develop features of dry AMD like ..
  4. Rosenfeld R, Piccirillo J, Chandrasekhar S, Brook I, Ashok Kumar K, Kramper M, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152:S1-S39 pubmed publisher
    ..group made strong recommendations that clinicians (1) should distinguish presumed ABRS from acute rhinosinusitis (ARS) caused by viral upper respiratory infections and noninfectious conditions and (2) should confirm a clinical ..
  5. Bethea C, Belikova Y, Phu K, Mammerella G. Reproductive steroid receptors and actions in the locus coeruleus of male macaques: Part of an aggression circuit?. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:210-22 pubmed publisher
    ..These experiments follow our observations that serotonin neurons lack androgen receptors (ARs), and yet respond to androgens...
  6. Kazan K, GARDINER D. FUSARIUM CROWN ROT CAUSED BY FUSARIUM PSEUDOGRAMINEARUM IN CEREAL CROPS: RECENT PROGRESS AND FUTURE PROSPECTS. Mol Plant Pathol. 2017;: pubmed publisher
    ..Useful websites: https://nt.ars-grin.gov/fungaldatabases/; http://plantpath.psu.edu/facilities/fusarium-research-center; https://nt.ars-grin...
  7. Piltonen T. Polycystic ovary syndrome: Endometrial markers. Best Pract Res Clin Obstet Gynaecol. 2016;37:66-79 pubmed publisher
    ..in women with PCOS are related to steroid hormone action (ERs (estrogen receptors), PRs (progesterone receptors), ARs (androgen receptors), and steroid receptor coactivators), endometrial receptivity/decidualization (HOXA10, ?v?3 ..
  8. Ge R, Tornero D, Hirota M, Monni E, Laterza C, Lindvall O, et al. Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke. J Neuroinflammation. 2017;14:153 pubmed publisher
    ..We found that CP responded to cortical stroke by upregulation of gene expression for several possible mediators of MDM trafficking and, concomitantly, MDMs increased in CP and cerebrospinal fluid (CSF)...
  9. Li X, Zheng Y, Zheng Y, Huang Y, Zhang Y, Jia L, et al. Circular RNA CDR1as regulates osteoblastic differentiation of periodontal ligament stem cells via the miR-7/GDF5/SMAD and p38 MAPK signaling pathway. Stem Cell Res Ther. 2018;9:232 pubmed publisher
    ..Alkaline phosphatase (ALP) and alizarin red S (ARS) staining were used to detect the activity of osteoblasts and mineral deposition...
  10. Basu M, Courtney S, Brinton M. Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells. PLoS Pathog. 2017;13:e1006240 pubmed publisher
    ..oxidative stress in infected cells but flavivirus-infected cells paradoxically develop resistance to arsenite (Ars)-induced SG formation with time after infection...
  11. Zou Y, Peng L, Weng S, Liang D, Fan Z, Wu Z, et al. Characterization and expression of androgen receptors in olive flounder. Gene. 2018;683:184-194 pubmed publisher
    ..sexual maturation, and spermatogenesis in vertebrates, which is mainly mediated by androgen receptors (ARs)...
  12. Téllez J, Romero I, Soares M, Steindel M, Romanha A. Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..We analyzed functional changes in the expression of human MDM genes and proteins during in vitro infection by Leishmania braziliensis and treatment with Glucantime ..
  13. Zou Y, Yang X, Yuan S, Zhang P, Ye Y, Li Y. Downregulation of dickkopf-1 enhances the proliferation and osteogenic potential of fibroblasts isolated from ankylosing spondylitis patients via the Wnt/?-catenin signaling pathway in vitro. Connect Tissue Res. 2016;57:200-11 pubmed publisher
    ..Alizarin red staining (ARS) was also used to observe biomineralization activity...
  14. Efferth T. From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy. Semin Cancer Biol. 2017;46:65-83 pubmed publisher
    ..Its active ingredient, artemisinin (ARS), has been developed as antimalarial drug and is used worldwide...
  15. Wang B, Xu M, Li W, Li X, Zheng Q, Niu X. Aerobic exercise protects against pressure overload-induced cardiac dysfunction and hypertrophy via ?3-AR-nNOS-NO activation. PLoS ONE. 2017;12:e0179648 pubmed publisher
    ..The aim of this study is to determine the role of ?3-adrenergic receptors (?3-ARs), NOS activation, and NO metabolites (nitrite and nitrosothiols) in the sustained cardioprotective effects of ..
  16. Wang P, Margolis C, Lin G, Buza E, Quick S, Raj K, et al. Mucopolysaccharidosis Type VI in a Great Dane Caused by a Nonsense Mutation in the ARSB Gene. Vet Pathol. 2017;:300985817732115 pubmed publisher
    ..Clinical and pathologic evaluations, urine glycosaminoglycan analyses, lysosomal enzyme assays, and ARSB sequencing were performed...
  17. Młodawska W, Grzesiak M, Kochan J, Nowak A. Intrafollicular level of steroid hormones and the expression of androgen receptor in the equine ovary at puberty. Theriogenology. 2018;121:13-20 pubmed publisher
    ..In summary, the ovaries of fillies aged at least 6 months are capable of active steroidogenesis. ARs are present either in the cell nuclei or cytoplasm of all compartments of the equine ovary...
  18. Li C, Sun D, Zhang S, Yang S, Alim M, Zhang Q, et al. Genetic effects of FASN, PPARGC1A, ABCG2 and IGF1 revealing the association with milk fatty acids in a Chinese Holstein cattle population based on a post genome-wide association study. BMC Genet. 2016;17:110 pubmed publisher
    A previous genome-wide association study deduced that one (ARS-BFGL-NGS-39328), two (Hapmap26001-BTC-038813 and Hapmap31284-BTC-039204), two (Hapmap26001-BTC-038813 and BTB-00246150), and one (Hapmap50366-BTA-46960) genome-wide ..
  19. Victorio J, Clerici S, Palacios R, Alonso M, Vassallo D, Jaffe I, et al. Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by ?-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue. Hypertension. 2016;68:726-35 pubmed publisher
    Sustained stimulation of ?-adrenoceptors (?-ARs) and activation of renin-angiotensin-aldosterone system are common features of cardiovascular diseases with rising sympathetic activation, including essential hypertension, myocardial ..
  20. Bewley M, Belchamber K, Chana K, Budd R, Donaldson G, Wedzicha J, et al. Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD. PLoS ONE. 2016;11:e0163139 pubmed publisher
    ..Alveolar macrophages (AM) obtained from broncho-alveolar lavage (BAL) or monocyte-derived macrophages (MDM) from COPD patients (GOLD stage II/III) enrolled from a well characterized clinical cohort (MRC COPD-MAP consortium)..
  21. Clark B, Prough R, Klinge C. Mechanisms of Action of Dehydroepiandrosterone. Vitam Horm. 2018;108:29-73 pubmed publisher
    ..NMDA), and sigma-1 (S1R) receptors; by binding steroid receptors: androgen and estrogen receptors (ARs, ER?, or ER?); or by their metabolism to more potent sex steroid hormones, e.g...
  22. George J, Patterson A, Tanwar P, Kajdacsy Balla A, Prins G, TEIXEIRA J. Specific deletion of LKB1/Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice. Proc Natl Acad Sci U S A. 2017;114:3445-3450 pubmed publisher
    ..tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Müllerian duct mesenchyme (MDM), the caudal remnant of which is thought to be assimilated by the urogenital sinus primordial mesenchyme in males ..
  23. Guha D, Wagner M, Ayyavoo V. Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury. J Neuroinflammation. 2018;15:126 pubmed publisher
    ..to Ng loss was accomplished by exposing dSH-SY5Y cells to HIV-1 and mock-infected monocyte-derived macrophage (MDM) supernatants or HIV-1 NLYU2 pseudotyped with VSV-G-Env...
  24. Anaya J, Rodríguez Y, Monsalve D, Vega D, Ojeda E, González Bravo D, et al. A comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombia. J Autoimmun. 2017;77:123-138 pubmed publisher
    ..surveillance system were used to calculate the basic reproduction number (R0) and the attack rates (ARs) as well as to develop epidemiological maps...
  25. Cowley P, Wang G, Joshi S, Swigart P, Lovett D, Simpson P, et al. ?1A-Subtype adrenergic agonist therapy for the failing right ventricle. Am J Physiol Heart Circ Physiol. 2017;313:H1109-H1118 pubmed publisher
    ..Signaling by ?1-adrenergic receptors (?1-ARs), in particular the ?1A-subtype, mediate cardioprotective effects in multiple heart failure models...
  26. Li X, Cui P, Jiang H, Guo Y, Pishdari B, Hu M, et al. Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action. Am J Transl Res. 2015;7:574-86 pubmed
    ..unclear in previous studies if endometrial GLUT4 expression is regulated by androgen-dependent androgen receptors (ARs) and/or the insulin receptor/Akt/mTOR signaling network...
  27. Sütterlin S, Téllez Castillo C, Anselem L, Yin H, Bray J, Maiden M. Heavy Metal Susceptibility of Escherichia coli Isolated from Urine Samples from Sweden, Germany, and Spain. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Isolates of the resistant group exhibited the chromosomal ars operon and belonged to non-B2 phylogenetic groups; in contrast, within the B2 phylogroup, no ars operon ..
  28. Arredondo J, Chernyavsky A, Grando S. Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells. Biochem Pharmacol. 2007;74:1315-9 pubmed
    ..Thus, the anti-tumorigenic activities of SLURP-1 and -2 were demonstrated both in vitro and in vivo. The obtained results suggest that SLURP-like proteins may become useful for developing novel anti-cancer therapies. ..
  29. Payandeh M, Shazad B, Madani S, Ramezani M, Sadeghi M. Androgen Receptor Expression and its Correlation with Other Risk Factors in Triple Negative Breast Cancers: a Report from Western Iran. Asian Pac J Cancer Prev. 2016;17:3321-4 pubmed
    Androgen receptors (ARs) are expressed in more than 70% of breast cancers (BCs) and have been implicated in BC pathogenesis. Some triple negative (TN)BC tumors express AR and may benefit from ARtargeted therapies...
  30. Zhang J, Zhang G, Ni C, Cheng R, Liang J, Li M, et al. Nagashima-type palmoplantar keratosis in a Chinese Han population. Mol Med Rep. 2016;14:4049-4054 pubmed publisher
    ..Mutation screening was performed by direct sequencing of the entire coding regions of SERPINB7, SLURP1, AQP5, CSTA, KRT1 and KRT9 genes. Direct sequencing of SERPINB7 revealed five homozygous founder mutations (c...
  31. Fang X, Chen Z, Miao G, Zhang L. Expression of ?1- and ?2-adrenergic receptors in the lungs and changes in the levels of corresponding autoantibodies in an aged rat model of heart failure. Int J Mol Med. 2016;38:1933-1939 pubmed publisher
    adrenergic receptors (?-ARs) and anti-?1-AR autoantibodies play important roles in heart failure...
  32. Zawilska P, Cieslik Boczula K. Laurdan emission study of the cholesterol-like effect of long-chain alkylresorcinols on the structure of dipalmitoylphosphocholine and sphingomyelin membranes. Biophys Chem. 2017;221:1-9 pubmed publisher
    Long-chain alkylresorcinols (ARs) are commonly found in plant and bacteria cells, and they exhibit a wide variety of biological effects, including antifungal, antitumor, and antiphrastic activities...
  33. Robinson T, Zhang M, Ochsenbauer C, Smythies L, CRON R. CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages. Virology. 2017;504:79-87 pubmed publisher
    ..Here, we found that M2 monocyte derived macrophages (MDM) were significantly more permissive to productive infection by R5-tropic HIV-1 strains, including transmitted ..
  34. Walter J, Noll I, Feig M, Weiss B, Claus H, Werner G, et al. Decline in the proportion of methicillin resistance among Staphylococcus aureus isolates from non-invasive samples and in outpatient settings, and changes in the co-resistance profiles: an analysis of data collected within the Antimicrobial Resistanc. BMC Infect Dis. 2017;17:169 pubmed publisher
    ..We analysed data from the Antimicrobial Resistance Surveillance Network (ARS). We included in the analysis the first isolate of S...
  35. Wei Z, Semiat R. Applying a modified Donnan model to describe the surface complexation of chromate to iron oxyhydroxide agglomerates with heteromorphous pores. J Colloid Interface Sci. 2017;506:66-75 pubmed publisher
    In this study, a modified Donnan model (mDM) is incorporated into surface complexation model (SCM) to better understand the physicochemical processes for adsorption of hexavalent chromium, Cr(VI), on porous iron oxyhydroxide agglomerates ..
  36. Kesselheim A, Ashton E, Bockenhauer D. Potential and pitfalls in the genetic diagnosis of kidney diseases. Clin Kidney J. 2017;10:581-585 pubmed publisher
    ..The article by Ars and Torra in this issue of the Clinical Kidney Journal provides examples of the ever-increasing ability to ..
  37. Wang J, Li H, Qiu S, Dong Z, Xiang X, Zhang D. MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI. Cell Death Dis. 2017;8:e3120 pubmed publisher
    ..caspase activity in HK-2 cells, which was accompanied by downregulation of p53, and upregulation of MITF, HDGF and MDM-4 together...
  38. Uysal B, Yaman D, Sarac O, Akçay E, Cagil N. Sterile keratitis after uneventful corneal collagen cross-linking in a patient with Axenfeld-Rieger syndrome. Int Ophthalmol. 2018;: pubmed publisher
    To report on a keratoconus (KC) patient with Axenfeld-Rieger syndrome (ARS) who developed sterile keratitis after accelerated corneal collagen cross-linking (CXL)...
  39. da Costa C, Gaeta M, de Araujo Mariath J, Offringa R, Fett Neto A. Comparative adventitious root development in pre-etiolated and flooded Arabidopsis hypocotyls exposed to different auxins. Plant Physiol Biochem. 2018;127:161-168 pubmed publisher
    Adventitious roots (ARs) emerge from stems, leaves or hypocotyls, being strategic for clonal propagation. ARs may develop spontaneously, upon environmental stress or hormonal treatment...
  40. Drummond E, Dawson L, Finch P, Li W, Guo T, Kingery W, et al. Increased bilateral expression of α1-adrenoceptors on peripheral nerves, blood vessels and keratinocytes does not account for pain or neuroinflammatory changes after distal tibia fracture in rats. Neuroscience. 2014;281:99-109 pubmed publisher
    ..nerve injury and inflammation, noradrenaline augments pain via actions on up-regulated α1-adrenoceptors (α1-ARs)...
  41. Matsumoto K, Miyamoto Y, Shimada K, Morisawa Y, Zipse H, Suga S, et al. Low temperature in situ Raman spectroscopy of an electro-generated arylbis(arylthio)sulfonium ion. Chem Commun (Camb). 2015;51:13106-9 pubmed publisher
    ..It was effective for monitoring the generation of ArS(ArSSAr)(+) by the electrochemical oxidation of ArSSAr (Ar = p-FC6H4) in Bu4NBF4/CH2Cl2 at 195 K...
  42. Golec J, Duan J, Aparicio E, Hough Goldstein J. Life History, Reproductive Biology, and Larval Development of Ontsira mellipes (Hymenoptera: Braconidae), a Newly Associated Parasitoid of the Invasive Asian Longhorned Beetle (Coleoptera: Cerambycidae). J Econ Entomol. 2016;109:1545-54 pubmed publisher
    ..Ontsira mellipes Ashmead (Hymenoptera: Braconidae) has been continually reared on A. glabripennis larvae at USDA-ARS BIIRU since 2010, and has been identified as a potential new-association biocontrol agent...
  43. Lyons L, Grahn R, Genova F, Beccaglia M, Hopwood J, Longeri M. Mucopolysaccharidosis VI in cats - clarification regarding genetic testing. BMC Vet Res. 2016;12:136 pubmed publisher
    ..1427T>C) and the D520N (c.1558G>A) variants in arylsulfatase B (ARSB), has come under scrutiny. No health problems are associated with the D520N (c...
  44. Phillips S, Hill S, Lipscomb L, Africa J. Altering the Approach: Open Minimally Invasive Renal Transplant in Obese Patients Through the Anterior Rectus Sheath. Urology. 2017;105:192-196 pubmed publisher
    ..results, and outcomes were retrospectively collected for the conventional (CON) and anterior rectus sheath (ARS) approaches until August 21, 2015...
  45. Zajdel A, Kałucka M, Kokoszka Mikołaj E, Wilczok A. Osteogenic differentiation of human mesenchymal stem cells from adipose tissue and Wharton's jelly of the umbilical cord. Acta Biochim Pol. 2017;64:365-369 pubmed publisher
    ..Osteogenic differentiation of MSCs was detected and quantified by alizarin red S (ARS) staining for calcium deposition and alkaline phosphatase (ALP) activity, osteoprotegerin (OPG), and osteocalcin (..
  46. Singhal S, Kirkpatrick D, Masuda T, Gerhardt J, Mittal S. Primary and Redo Antireflux Surgery: Outcomes and Lessons Learned. J Gastrointest Surg. 2018;22:177-186 pubmed publisher
    Some patients require one or more reoperative interventions after undergoing primary antireflux surgery (ARS). We compared outcomes after primary and reoperative ARS...
  47. Fattorini L, Veloccia A, Della Rovere F, D Angeli S, Falasca G, Altamura M. Indole-3-butyric acid promotes adventitious rooting in Arabidopsis thaliana thin cell layers by conversion into indole-3-acetic acid and stimulation of anthranilate synthase activity. BMC Plant Biol. 2017;17:121 pubmed publisher
    ..stem cuttings, 10 ?M IBA is more AR-inductive than 10 ?M IAA, and, in thin cell layers (TCLs), IBA induces ARs when combined with 0.1 ?M kinetin (Kin)...
  48. Lloyd A, Davies C, Miron V. Microglia: origins, homeostasis, and roles in myelin repair. Curr Opin Neurobiol. 2017;47:113-120 pubmed publisher
    ..Together with monocyte-derived macrophages (MDM), microglia coordinate the regeneration of CNS myelin around axons, termed remyelination...
  49. Costales M, Alam M, Cavanaugh C, Williams K. Extracellular adenosine produced by ecto-5'-nucleotidase (CD73) regulates macrophage pro-inflammatory responses, nitric oxide production, and favors Salmonella persistence. Nitric Oxide. 2018;72:7-15 pubmed publisher
    ..Adenosine produced by CD39/CD73 acts via adenosine receptors (ARs). CD73 is expressed by a variety of cell types and mediates anti-inflammatory responses...
  50. Burnand K, Roberts A, Bouty A, Nightingale M, Campbell M, Heloury Y. Laparoscopic nephrectomy for Wilms' tumor: Can we expand on the current SIOP criteria?. J Pediatr Urol. 2018;14:253.e1-253.e8 pubmed publisher
    ..There was one local recurrence. SIOP criteria are conservative and safe. Indications can be extended for teams experienced in surgical oncology and laparoscopy after agreement at a multidisciplinary meeting (MDM).
  51. Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann W, et al. Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. Protein Sci. 1999;8:810-9 pubmed
    ..SLURP-1 is encoded by the ARS (component B)-81/s locus, and appears to be the first mammalian member of the Ly-6/uPAR family lacking a GPI-..
  52. Edagwa B, Guo D, Puligujja P, Chen H, McMillan J, Liu X, et al. Long-acting antituberculous therapeutic nanoparticles target macrophage endosomes. FASEB J. 2014;28:5071-82 pubmed publisher
    ..1 μg/10(6) cells for native drugs. High RIF and INHP levels were retained in MDM for >15 d following nanoparticle loading...
  53. Toro A, Pérez Pérez A, Corrales Gutiérrez I, Sánchez Margalet V, Varone C. Mechanisms involved in p53 downregulation by leptin in trophoblastic cells. Placenta. 2015;36:1266-75 pubmed publisher
    ..Finally, in order to assess leptin effect on p53 half-life experiments with cycloheximide were performed and MDM-2 expression was analyzed. Leptin diminished p53 half-life and up-regulated MDM-2 expression...
  54. Jo H, Corte T, Moodley Y, Levin K, Westall G, Hopkins P, et al. Evaluating the interstitial lung disease multidisciplinary meeting: a survey of expert centres. BMC Pulm Med. 2016;16:22 pubmed publisher
    Multidisciplinary meetings (MDM) are the current "gold standard" in interstitial lung disease (ILD) diagnosis and comprise inter-disciplinary discussion of multiple forms of information to provide diagnostic and management outputs...
  55. Liaci E, Bach M, Tebartz van Elst L, Heinrich S, Kornmeier J. Ambiguity in Tactile Apparent Motion Perception. PLoS ONE. 2016;11:e0152736 pubmed publisher
    ..We presented tactile SAM stimuli and varied the ARs, while participants reported the perceived motion directions...
  56. Politis C, Wiersum J, Richardson C, Robillard P, Jorgensen J, Renaudier P, et al. The International Haemovigilance Network Database for the Surveillance of Adverse Reactions and Events in Donors and Recipients of Blood Components: technical issues and results. Vox Sang. 2016;111:409-417 pubmed publisher
    The International Haemovigilance Network's ISTARE is an online database for surveillance of all adverse reactions (ARs) and adverse events (AEs) associated with donation of blood and transfusion of blood components, irrespective of ..
  57. Landeros R, Jobe S, Aranda Pino G, Lopez G, Zheng J, Magness R. Convergent ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) signalling mediate catecholoestradiol-induced proliferation of ovine uterine artery endothelial cells. J Physiol. 2017;595:4663-4676 pubmed publisher
    ..proliferation of pregnancy-derived ovine uterine artery endothelial cells (P-UAECs) through ?-adrenoceptors (?-ARs) and independently of the classic oestrogen receptors (ERs)...
  58. Dalwadi D, Schetz J. Comparative Exploration of the Structure-Activity Space of Cloned ?-Like Octopamine Receptors from a Marine and a Terrestrial Arthropod. Mol Pharmacol. 2017;92:297-309 pubmed publisher
    ..to be the evolutionary precursor to the vertebrate ?2-adrenergic receptors (?2-ARs) based upon sequence similarity and the ability to interact with norepinephrine and a number of compounds that bind ..
  59. Cannavo A, Rengo G, Liccardo D, Pun A, Gao E, George A, et al. ?1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via ?3AR-Dependent Protective Sphingosine-1 Phosphate Signaling. J Am Coll Cardiol. 2017;70:182-192 pubmed publisher
    ..showed that, in cardiomyocytes, a reciprocal down-regulation occurs between ?1-adrenergic receptors (ARs) and the cardioprotective sphingosine-1-phosphate (S1P) receptor-1 (S1PR1)...
  60. Waldron A, Cahan S, Franklyn C, Ebert A. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. PLoS ONE. 2017;12:e0185317 pubmed publisher
    Histidyl tRNA Synthetase (HARS) is a member of the aminoacyl tRNA synthetase (ARS) family of enzymes...
  61. Dong C, Liu H, Zhang Z, Zhao H, Zhao H, Huang Y, et al. The influence of MicroRNA-150 in Osteoblast Matrix Mineralization. J Cell Biochem. 2015;116:2970-9 pubmed publisher
    ..Matrix mineralization was detected by alizarin red S (ARS) staining and flow cytometry was employed to quantify apoptosis in each group...
  62. Fitzgerald M, Otis J, Mueller D. Dissociation of β1- and β2-adrenergic receptor subtypes in the retrieval of cocaine-associated memory. Behav Brain Res. 2016;296:94-99 pubmed publisher
    ..CPP) procedure, we examined whether retrieval of a cocaine CPP memory is mediated collectively by β1- and β2-ARs, or by one of these β-AR subtypes alone...
  63. White M, Kodaman N, Harder R, Asselbergs F, Vaughan D, Brown N, et al. Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. PLoS ONE. 2015;10:e0136379 pubmed publisher
    ..Three variants associated with median PAI-1, the most significant of which was in the gene arylsulfatase B (ARSB) (p = 1.09 x 10(-7))...
  64. Moriwaki Y, Takada K, Nagasaki T, Kubo N, Ishii T, Kose K, et al. IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against Staphylococcus aureus. PLoS ONE. 2015;10:e0140750 pubmed publisher
    b>SLURP1 is the causal gene for Mal de Meleda (MDM), an autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma and transgressive keratosis...
  65. Zhang M, Davis J, Li C, Gao J, Huang W, Lambert N, et al. GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export. Mol Cell Biol. 2016;36:1152-63 pubmed publisher
    ..Here, we have studied the regulation of cell surface transport of α2-adrenergic receptors (α2-ARs) by GGA3 (Golgi-localized, γ-adaptin ear domain homology, ADP ribosylation factor-binding protein 3), a ..
  66. Powers K, NISHIKAWA K, Joumaa V, Herzog W. Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin. J Exp Biol. 2016;219:1311-6 pubmed publisher
    ..We investigated this mechanism using a genetic mutation (mdm) with a small but crucial deletion in the titin protein...
  67. Fernández M, Morel B, Ramos J, Krell T. Paralogous Regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a Basis for Arsenic Biosensor Development. Appl Environ Microbiol. 2016;82:4133-4144 pubmed publisher
    ..Pseudomonas putida KT2440 is a model organism for such bacteria, and their duplicated ars operons and in particular their ArsR transcription regulators have been studied in depth by in vivo approaches...
  68. Thakare V, Dhakane V, Patel B. Potential antidepressant-like activity of silymarin in the acute restraint stress in mice: Modulation of corticosterone and oxidative stress response in cerebral cortex and hippocampus. Pharmacol Rep. 2016;68:1020-7 pubmed publisher
    ..study was to investigate the potential antidepressant-like activity of silymarin in the acute restraint stress (ARS) in mice...
  69. Voora D, Rao A, Jalagadugula G, Myers R, Harris E, Ortel T, et al. Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer. EBioMedicine. 2016;11:157-164 pubmed publisher
    ..We previously identified an aspirin response signature (ARS) in blood consisting of 62 co-expressed transcripts that correlated with aspirin's effects on platelets and ..
  70. Xu K, Tzankova V, Li C, Sharma S. Intravenous fluorescein angiography-associated adverse reactions. Can J Ophthalmol. 2016;51:321-325 pubmed publisher
    To assess (i) the adverse reactions (ARs) associated with intravenous fluorescein angiography (IVFA); (ii) the relationship between a known history of IVFA-associated AR and ARs on the subsequent IVFA test; and (iii) the dose-response ..
  71. Lahav Baratz S, Kravtsova Ivantsiv Y, Golan S, Ciechanover A. The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2. Biochem Biophys Res Commun. 2017;482:106-111 pubmed publisher
    ..between the deubiquitinating enzyme - ubiquitin specific protease 26 (USP26), and the oncoprotein E3 ligase - (Mdm-2). We analyzed the half-life time of USP26 in HEK293 cells...
  72. Zhao X, Liu M, Li J, Yin S, Wu Y, Wang A. Antimalarial agent artesunate protects Concanavalin A-induced autoimmune hepatitis in mice by inhibiting inflammatory responses. Chem Biol Interact. 2017;274:116-123 pubmed publisher
    The anti-malarial drug artesunate (ARS) has been shown to possess anti-inflammatory activity. Its effect on autoimmune hepatitis remains unclear...
  73. Chang J. Biotransformation of arsenite and bacterial aox activity in drinking water produced from surface water of floating houses: Arsenic contamination in Cambodia. Environ Pollut. 2015;206:315-23 pubmed publisher
    ..There is a biogeochemical cycle of activity involving arsenite oxidase aox system and the ars (arsenic resistance system) gene operon and aoxR leader gene activity in Alcaligenes faecalis SRR-11 and aoxS ..
  74. Rohrmann S, Nimptsch K, Sinha R, Willett W, Giovannucci E, Platz E, et al. Intake of Meat Mutagens and Risk of Prostate Cancer in a Cohort of U.S. Health Professionals. Cancer Epidemiol Biomarkers Prev. 2015;24:1557-63 pubmed publisher
    ..MeIQx), and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and a meat-derived mutagenicity (MDM) index were assessed using a cooking method questionnaire administered in 1996...
  75. Uttarilli A, Ranganath P, Jain S, Prasad C, Sinha A, Verma I, et al. Novel mutations of the arylsulphatase B (ARSB) gene in Indian patients with mucopolysaccharidosis type VI. Indian J Med Res. 2015;142:414-25 pubmed publisher
    ..enzymatic activity of N-acetyl galactosamine-4-sulphatase resulting from mutations in the arylsulphatase B (ARSB) gene. The ARSB gene is located on chromosome 5q11-q13 and is composed of eight exons...
  76. Holschbach M, Bier D, Sihver W, Schulze A, Neumaier B. Synthesis and Pharmacological Evaluation of Identified and Putative Metabolites of the A1 Adenosine Receptor Antagonist 8-Cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX). ChemMedChem. 2017;12:770-784 pubmed publisher
    ..sup>18 F]CPFPX), used in imaging human brain A1 ARs by positron emission tomography (PET), is stable in the brain, but rapidly undergoes transformation into one major (..
  77. Mitronova G, Lukinavicius G, Butkevich A, Kohl T, Belov V, Lehnart S, et al. High-Affinity Functional Fluorescent Ligands for Human ?-Adrenoceptors. Sci Rep. 2017;7:12319 pubmed publisher
    ..Carazolol-derived probes are fluorogenic and allow no-wash imaging experiments. STED microscopy of ?2ARs stained at the native expression level on pancreatic CAPAN cells provides two-fold improvement in lateral optical ..
  78. Gavriel H, Jabarin B, Israel O, Eviatar E. Conservative Management for Subperiosteal Orbital Abscess in Adults: A 20-Year Experience. Ann Otol Rhinol Laryngol. 2018;127:162-166 pubmed publisher
    Orbital complications (OC) secondary to acute rhinosinusitis (ARS) in adults are less common than in children, with assumed worse outcome. Adults with OC secondary to ARS between 1994 and 2014 were reviewed retrospectively...
  79. Soave M, Cseke G, Hutchings C, Brown A, Woolard J, Hill S. A monoclonal antibody raised against a thermo-stabilised ?1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of ?1-adrenoceptors expressed in stable cell lines. Biochem Pharmacol. 2018;147:38-54 pubmed publisher
    ..against a purified thermo-stabilised turkey ?1-adrenoceptor (?1AR-m23 StaR), on ?1-ARs expressed in CHO-K1 or HEK 293 cells...
  80. Swamynathan S, Swamynathan S. SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator. Invest Ophthalmol Vis Sci. 2014;55:6251-61 pubmed publisher
    ..of the secreted lymphocyte antigen (Ly6)/urokinase-type plasminogen activator receptor (uPAR)-related protein-1 (SLURP1), abundantly expressed in the cornea and associated with the hyperkeratotic disorder Mal de Meleda...
  81. Kim A, Kim Y, Lee S, Yoon Y, Kim W, Kweon O. Effect of Gelatin on Osteogenic Cell Sheet Formation Using Canine Adipose-Derived Mesenchymal Stem Cells. Cell Transplant. 2017;26:115-123 pubmed publisher
    ..number of calcium depositions were assessed by quantitative real-time polymerase chain reaction and Alizarin red S (ARS) staining, respectively. GCSs were thicker and stronger than OCSs...
  82. Jespers W, Oliveira A, Prieto Díaz R, Majellaro M, Aqvist J, Sotelo E, et al. Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors. Molecules. 2017;22: pubmed publisher
    The four receptors that signal for adenosine, A?, A2A, A2B and A? ARs, belong to the superfamily of G protein-coupled receptors (GPCRs)...
  83. Szymanska E, Drabczyńska A, Karcz T, Muller C, Köse M, Karolak Wojciechowska J, et al. Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors. Bioorg Med Chem. 2016;24:4347-4362 pubmed publisher
    ..32 pyrimido- and 5 tetrahydropyrazino[2,1-f]purinediones was obtained and evaluated for their adenosine receptors (ARs) affinities...
  84. Webster C, Pino E, Carr C, Wu L, Zhou B, Cedillo L, et al. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. Cell Rep. 2017;20:627-640 pubmed publisher
    ..Reduced function of cytoplasmic aminoacyl tRNA synthetases (ARS genes) increases fat mass and extends starvation survival, whereas reduced proteasomal function reduces fat and ..
  85. Mazzanti G, Moro P, Raschi E, Da Cas R, Menniti Ippolito F. Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system. Br J Clin Pharmacol. 2017;83:894-908 pubmed publisher
    ..We aim to describe the safety profile of RYR by analysing spontaneous reports of suspected adverse reactions (ARs).
  86. Murray M. Anticoagulant rodenticide exposure and toxicosis in four species of birds of prey in Massachusetts, USA, 2012-2016, in relation to use of rodenticides by pest management professionals. Ecotoxicology. 2017;26:1041-1050 pubmed publisher
    ..admitted to a wildlife clinic in Massachusetts, USA, from 2012-2016 for residues of anticoagulant rodenticides (ARs). Ninety-four birds were analyzed; 16 were symptomatic for AR toxicosis, and 78 asymptomatic...
  87. Metaxa S, Missouris C, Mavrogianni D, Miliou A, Oikonomou E, Vlismas A, et al. Polymorphism Gln27Glu of ?2 adrenergic receptors in patients with ischaemic cardiomyopathy. Curr Vasc Pharmacol. 2017;: pubmed publisher
    Polymorphisms of the adrenergic receptors (ARs) might affect the development and progression of heart failure (HF) and the response to treatment with ?-blockade therapy.
  88. Esposito G, Santana L, Dilly K, Cruz J, Mao L, Lederer W, et al. Cellular and functional defects in a mouse model of heart failure. Am J Physiol Heart Circ Physiol. 2000;279:H3101-12 pubmed
    ..e., loss of the structural protein MLP), downregulation and desensitization of the beta-ARs may play a pivotal role in the pathogenesis...
  89. Kamin W, Funk P, Seifert G, Zimmermann A, Lehmacher W. EPs 7630 is effective and safe in children under 6 years with acute respiratory tract infections: clinical studies revisited. Curr Med Res Opin. 2017;:1-24 pubmed publisher
    ..open-label study was identified in acute tonsillopharyngitis (ATP), and one in acute rhinosinusitis (ARS)...
  90. Kozlov G, Wong K, Wang W, Skubák P, Muñoz Escobar J, Liu Y, et al. Ankyrin repeats as a dimerization module. Biochem Biophys Res Commun. 2018;495:1002-1007 pubmed publisher
    ..2 Å resolution. The structure shows seven ankyrin repeats (ARs) with unique structural features. AnkC forms a dimer along the outer surface of loops between ARs...
  91. Feferman L, Deaton R, Bhattacharyya S, Xie H, Gann P, Melamed J, et al. Arylsulfatase B is reduced in prostate cancer recurrences. Cancer Biomark. 2017;: pubmed publisher
    Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for their degradation...
  92. Weninger A, Fischer J, Raschmanová H, Kniely C, Vogl T, Glieder A. Expanding the CRISPR/Cas9 toolkit for Pichia pastoris with efficient donor integration and alternative resistance markers. J Cell Biochem. 2017;: pubmed publisher
    ..donor cassette integration was also improved up to 25-fold by placing an autonomously replicating sequence (ARS) on the donor cassette...