SLURP1

Summary

Gene Symbol: SLURP1
Description: secreted LY6/PLAUR domain containing 1
Alias: ANUP, ARS, ArsB, LY6LS, MDM, secreted Ly-6/uPAR-related protein 1, ARS(component B)-81/S, SLURP-1, anti-neoplastic urinary protein, lymphocyte antigen 6-like secreted, secreted Ly6/uPAR related protein 1
Species: human

Top Publications

  1. pmc Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates
    S Li
    Centre for Virus Research, Westmead Millennium Institute, National Centre for HIV Virology Research, Westmead, NSW 2145, Australia
    J Virol 73:9741-55. 1999
  2. ncbi Biological effects of SLURP-1 on human keratinocytes
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    J Invest Dermatol 125:1236-41. 2005
  3. pmc Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases
    Alexander I Chernyavsky
    Department of Dermatology, University of California, Irvine, California 92697, USA
    Am J Physiol Cell Physiol 299:C903-11. 2010
  4. doi A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts
    T C A Phan
    School of Dentistry, Oral Biology Research Laboratory, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Nedlands, WA, Australia
    J Periodontal Res 45:331-6. 2010
  5. doi Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions
    Osamu Narumoto
    Department of Pharmacotherapy, Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
    Biochem Biophys Res Commun 398:713-8. 2010
  6. pmc Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily
    K Adermann
    Lower Saxony Institute for Peptide Research IPF, Hannover, Germany
    Protein Sci 8:810-9. 1999
  7. ncbi Mutations in the gene encoding SLURP-1 in Mal de Meleda
    J Fischer
    Centre National de Genotypage, 91057 Evry, France
    Hum Mol Genet 10:875-80. 2001
  8. ncbi Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates
    Katja Martina Eckl
    Gene Mapping Centre and Department of Molecular Genetics, Max Delbrück Centre Moecular Medicine, Berlin, Germany
    Hum Genet 112:50-6. 2003
  9. ncbi Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda
    Slaheddine Marrakchi
    CHU Heidi Chaker, Department of Dermatology, Sfax, Tunisia
    J Invest Dermatol 120:351-5. 2003
  10. ncbi Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda
    Fabrice Chimienti
    Laboratory for Cutaneous Biology, Dermatology Unit, Beaumont Hospital, CHUV, Lausanne, Switzerland
    Hum Mol Genet 12:3017-24. 2003

Research Grants

  1. Vitamin D Inhibition of HIV and M. Tuberculosis Coinfection in Macrophages
    Stephen A Spector; Fiscal Year: 2010
  2. Modeling monocyte and macrophage based gene therapy for neuroAIDS
    Yuanan Lu; Fiscal Year: 2013
  3. JIALIN CHARLES ZHENG; Fiscal Year: 2014
  4. Role of Host miRNAs in Persistent HIV Macrophage Infection
    Judy Lieberman; Fiscal Year: 2011
  5. In Vivo Reconstitution Models for NeuroAIDS and Beta-Amyloidosis
    Tsuneya Ikezu; Fiscal Year: 2010
  6. Novel Pathways of HAARTmediated Neuronal Toxicity in the Central Nervous System
    Kelly L Jordan Sciutto; Fiscal Year: 2010
  7. DENNIS LARRY KOLSON; Fiscal Year: 2015
  8. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2010
  9. Linda E Rivera; Fiscal Year: 2014
  10. INDUCTION OF APOPTOSIS BY HIV-1 VPR
    Vicente Planelles; Fiscal Year: 2010

Detail Information

Publications300 found, 100 shown here

  1. pmc Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates
    S Li
    Centre for Virus Research, Westmead Millennium Institute, National Centre for HIV Virology Research, Westmead, NSW 2145, Australia
    J Virol 73:9741-55. 1999
    ..Tropism and productive infection by HIV isolates in both monocytes and monocyte-derived macrophages (MDM) increased in advanced disease (HIV tropism for monocytes, 1 of 6 from categories I and II versus 11 of 21 [P = 0...
  2. ncbi Biological effects of SLURP-1 on human keratinocytes
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    J Invest Dermatol 125:1236-41. 2005
    ..These results suggest that the biological role of SLURP-1 in the epidermis is to provide fine tuning of the physiologic regulation of KC functions through the cholinergic pathways...
  3. pmc Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases
    Alexander I Chernyavsky
    Department of Dermatology, University of California, Irvine, California 92697, USA
    Am J Physiol Cell Physiol 299:C903-11. 2010
    ..Thus, there exists a previously not appreciated network of noncanonical auto/paracrine ligands of nAChR of the Ly-6 protein family, which merits further investigations...
  4. doi A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts
    T C A Phan
    School of Dentistry, Oral Biology Research Laboratory, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Nedlands, WA, Australia
    J Periodontal Res 45:331-6. 2010
    ..The aim of this study was to examine the role of a novel molecule, secreted mammalian Ly-6/urokinase-type plasminogen activator receptor-related protein 1 (SLURP-1), in periodontal ligament fibroblast survival...
  5. doi Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions
    Osamu Narumoto
    Department of Pharmacotherapy, Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
    Biochem Biophys Res Commun 398:713-8. 2010
    ..Those findings suggest that diminished expression of SLURP-1 in asthma attenuates its negative regulation of airway inflammation, and that perhaps changes in SLURP-1 expression could serve as a marker of airway damage in asthma...
  6. pmc Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily
    K Adermann
    Lower Saxony Institute for Peptide Research IPF, Hannover, Germany
    Protein Sci 8:810-9. 1999
    ..SLURP-1 is encoded by the ARS (component B)-81/s locus, and appears to be the first mammalian member of the Ly-6/uPAR family lacking a GPI-..
  7. ncbi Mutations in the gene encoding SLURP-1 in Mal de Meleda
    J Fischer
    Centre National de Genotypage, 91057 Evry, France
    Hum Mol Genet 10:875-80. 2001
    ..described interval of MDM on chromosome 8qter, and the identification of mutations in affected individuals in the ARS (component B) gene, encoding a protein named SLURP-1, for secreted Ly-6/uPAR related protein 1...
  8. ncbi Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates
    Katja Martina Eckl
    Gene Mapping Centre and Department of Molecular Genetics, Max Delbrück Centre Moecular Medicine, Berlin, Germany
    Hum Genet 112:50-6. 2003
    ..Mutations in the ARS (component B)-81/s gene ( LY6LS) on chromosome 8q24-qter, which encodes SLURP-1, have recently been identified in patients with MDM...
  9. ncbi Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda
    Slaheddine Marrakchi
    CHU Heidi Chaker, Department of Dermatology, Sfax, Tunisia
    J Invest Dermatol 120:351-5. 2003
    ..Four ancestral haplotypes were observed in 69 patients from countries around the Mediterranean basin, and an additional haplotype was found in the German and Scottish patients...
  10. ncbi Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda
    Fabrice Chimienti
    Laboratory for Cutaneous Biology, Dermatology Unit, Beaumont Hospital, CHUV, Lausanne, Switzerland
    Hum Mol Genet 12:3017-24. 2003
    ..Mal de Meleda is an autosomal recessive inflammatory and keratotic palmoplantar skin disorder due to mutations in the ARS B gene, encoding for SLURP-1 (secreted mammalian Ly-6/uPAR-related protein 1)...
  11. ncbi A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia
    C Charfeddine
    Laboratoire d Immunologie, Vaccinologie et Génétique Moléculaire, Institut Pasteur de Tunis, BP 74, 13 Place Pasteur, 1002 Tunis Belvedere, Tunisia
    Br J Dermatol 149:1108-15. 2003
    Mal de Meleda (MDM) is a rare autosomal recessive skin disorder which belongs to the clinically and genetically heterogeneous group of palmoplantar keratodermas (PPK)...
  12. doi Expression of the endogenous, nicotinic acetylcholine receptor ligand, SLURP-1, in human colon cancer
    A Pettersson
    School of Pure and Applied Natural Sciences, University of Kalmar, Kalmar, Sweden
    Auton Autacoid Pharmacol 28:109-16. 2008
    ..4. The current findings suggest that SLURP-1 participates in the regulation of gut immune functions and motility, as well as possibly playing a role in colon carcinogenesis/cancer progression...
  13. doi Mutations in the SLURP-1 gene underlie Mal de Meleda in three Pakistani families
    Muhammad Wajid
    Department of Dermatology, Columbia University, New York, NY, United States
    J Dermatol Sci 56:27-32. 2009
    Mal de Meleda (MDM) (MIM #248300) is an autosomal recessive palmoplantar keratoderma (PPK)...
  14. doi SLURP1 mutation-impaired T-cell activation in a family with mal de Meleda
    J W Tjiu
    Department of Dermatology, National Taiwan University Hospital, Chung Shan South Road, Taipei 100, Taiwan
    Br J Dermatol 164:47-53. 2011
    ..Among the family members, patients with the homozygous SLURP1 (previously known as ARS component B) mutation are prone to melanoma and viral infection, which might link to ..
  15. doi Diagnosis and treatment of polonium poisoning
    Robert D Jefferson
    Wolfson Unit of Clinical Pharmacology, Newcastle University, Newcastle, UK corrected
    Clin Toxicol (Phila) 47:379-92. 2009
    ..This article reviews the clinical features, diagnosis, and treatment of acute radiation syndrome (ARS) resulting from the ingestion of (210)Po...
  16. ncbi Mal de Meleda: a report of four cases from the United Arab Emirates
    G G Lestringant
    Tawam Hospital, Al Ain, United Arab Emirates
    Pediatr Dermatol 14:186-91. 1997
    Mal de Meleda (MDM), or recessive transgressive palmoplantar keratoderma, is a rare disorder. MDM may have originated as a founder mutation that occurred on the island of Meleda, now Mljet, in Croatia, where it was first described...
  17. ncbi Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells
    C Carpene
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 317, Institut Fédératif de Recherches 31, CHU Rangueil, Toulouse, France
    Naunyn Schmiedebergs Arch Pharmacol 359:310-21. 1999
    Numerous synthetic agonists selectively stimulate beta3-adrenoceptors (ARs)...
  18. ncbi Anthelmintic resistance on goat farms in Georgia: efficacy of anthelmintics against gastrointestinal nematodes in two selected goat herds
    T H Terrill
    School of Agriculture, Home Economics and Allied Programs, Fort Valley State University, Agricultural Research Station, Fort Valley, GA 31030, USA
    Vet Parasitol 97:261-8. 2001
    ..efficacy was determined in goat herds at the Fort Valley State University, Agricultural Research Station (FVSU-ARS) and the University of Georgia, College of Veterinary Medicine (UGA-CVM) using fecal egg count reduction (FECR) ..
  19. pmc Tracing the development of single memory-lineage B cells in a highly defined immune response
    A H Liu
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA
    J Exp Med 183:2053-63. 1996
    ..that constitutes a reproducible and predominant component of the memory antibody response to p-azophenylarsonate (Ars)...
  20. ncbi United States Department of Agriculture-Agricultural Research Service stored-grain areawide integrated pest management program
    Paul W Flinn
    Grain Marketing and Production Research Center, USDA, ARS, Manhattan, KS 66502, USA
    Pest Manag Sci 59:614-8. 2003
    The USDA Agricultural Research Service (ARS) funded a demonstration project (1998-2002) for areawide IPM for stored wheat in Kansas and Oklahoma...
  21. ncbi [Inhibitory effect of macrolide antibiotics on biofilm formation by Pseudomonas aeruginosa]
    K Kondoh
    Department of Otorhinolaryngology, Nagoya City University Medical School
    Nihon Jibiinkoka Gakkai Kaiho 101:25-36. 1998
    ..various concentrations of the macrolide antibiotics clarithromycin (CAM), erythromycin (EM) and midecamycin (MDM), at 37 degrees C for 7 days. The surfaces of the Teflon sheets were examined by electron microscopy...
  22. ncbi Functional analysis of a chromosomal arsenic resistance operon in Pseudomonas fluorescens strain MSP3
    S Prithivirajsingh
    Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Mol Biol Rep 28:63-72. 2001
    ..Nucleotide sequencing revealed the presence of three open reading frames homologous to the arsR, arsB and arsC genes of arsenic resistance...
  23. ncbi [Bacteriological, pharmacokinetic and clinical studies on a rokitamycin dry syrup in the pediatric field]
    Y Toyonaga
    Department of Pediatrics, Jikei University School of Medicine
    Jpn J Antibiot 41:720-38. 1988
    ..and 50 strains of Campylobacter jejuni were studied comparatively with activities of josamycin (JM), midecamycin (MDM), erythromycin (EM) and cefaclor (CCL) or ampicillin...
  24. pmc Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles
    Arnaud Beduneau
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 4:e4343. 2009
    ....
  25. ncbi Patterns of nucleotide substitutions inferred from the phylogenies of the class I major histocompatibility complex genes
    T Imanishi
    DNA Research Center, National Institute of Genetics, Shizuoka, Japan
    J Mol Evol 35:196-204. 1992
    ..The pattern at the antigen recognition sites (ARS) in functional MHC genes was remarkably different from that at the remaining coding region (non-ARS)...
  26. ncbi Microsomal steroid sulfatase: interactions with cytosolic steroid sulfotransferases
    F C Kauffman
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Chem Biol Interact 109:169-82. 1998
    ..Unlike ARSA and ARSB, which are lysosomal, steroid sulfate sulfatase (ARSC, also known as STS) is localized exclusively in the ..
  27. ncbi Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists
    Christa E Muller
    Pharmaceutical Institute Poppelsdorf, University of Bonn, Bonn, Germany
    J Med Chem 45:3440-50. 2002
    ..Substituents were introduced that confer high affinity for A(2A) or A(3) ARs, respectively...
  28. ncbi Quantitative comparison of the cytocidal effect of seven macrolide antibiotics on human periodontal ligament fibroblasts
    Noriko Maizumi
    Department of Pharmacology, The Nippon Dental University, School of Dentistry at Tokyo, Tokyo, Japan
    J Periodontal Res 37:250-4. 2002
    ..h to erythromycin (EM), clarithromycin (CAM), roxithromycin (RXM), azithromycin (AZM), josamycin (JM), midecamycin (MDM), and rokitamycin (RKM), and allowed to form colonies...
  29. ncbi Uptake of lactoferrin by mononuclear phagocytes inhibits their ability to form hydroxyl radical and protects them from membrane autoperoxidation
    B E Britigan
    Department of Internal Medicine and Research Service, VA Medical Center, Iowa City, IA 52246
    J Immunol 147:4271-7. 1991
    ..work by other investigators has suggested that mononuclear phagocytes (monocytes and monocyte-derived macrophages (MDM] have the capacity to bind exogenous lactoferrin via lactoferrin-specific membrane surface receptors...
  30. ncbi Relationship of some endogenous sex steroid hormones to leukocyte arylsulphatase A activities in pre- and postmenopausal healthy women
    P Oner
    Department of Biochemistry, Istanbul Medical Faculty, Capa, Turkiye
    Horm Metab Res 26:301-4. 1994
    ..in endogenous gonadal steroid hormones during fertile period to menopause might affect the Arylsulphatase A (ARS-A) activities in leukocytes in healthy women...
  31. ncbi Human macrophage-mediated biodegradation of polyurethanes: assessment of candidate enzyme activities
    Rosalind S Labow
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa Heart Institute, Ont, Canada
    Biomaterials 23:3969-75. 2002
    A predominant cell type associated with explanted failed devices is the monocyte-derived macrophage (MDM)...
  32. doi Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain
    Ipek Yalcin
    Institut des Neurosciences Cellulaires et Integratives, Centre National de la Recherche Scientifique, Strasbourg, France
    Exp Neurol 221:115-21. 2010
    Expression of beta(2)-adrenoceptors (beta(2)-ARs) within the nociceptive system suggested their potential implication in nociception and pain...
  33. ncbi Nature of the ligand recognized by a hapten- and carrier-specific, MHC-restricted T cell receptor
    E A Nalefski
    Program in Cell and Development Biology, Harvard Medical School, Boston, MA 02115
    J Immunol 150:3806-16. 1993
    ..We have identified a peptide fragment generated by enzymatic cleavage of arsonate-conjugated OVA (Ars-OVA), which stimulates D5 cells when presented by I-Ad-bearing APC...
  34. ncbi 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists
    Alaa M Hayallah
    University of Bonn, Pharmaceutical Institute Poppelsdorf, Bonn, Germany
    J Med Chem 45:1500-10. 2002
    ..1-Alkyl-8-phenylxanthine derivatives were found to exhibit high affinity for A2B adenosine receptors (ARs)...
  35. ncbi Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists
    Pier Giovanni Baraldi
    Dipartimento di Scienze Farmaceutiche and Dipartimento di Medicina Clinica e Sperimentale Sezione di Farmacologia, Universita di Ferrara, 44100 Ferrara Italy
    J Med Chem 47:1434-47. 2004
    ..relationships (SAR) of the xanthines synthesized in binding to recombinant human A(2B) adenosine receptors (ARs) in HEK-293 cells (HEK-A(2B)) and at other AR subtypes were explored...
  36. ncbi A field study evaluation for mitigating biofouling with chlorine dioxide or chlorine integrated with UV disinfection
    J L Rand
    Ivan Curry School of Engineering, Acadia University, Wolfville, NS, Canada B4P 2R6
    Water Res 41:1939-48. 2007
    ..Annular reactors (ARs) containing polycarbonate coupons were used to simulate EBMUD's 90-mile aqueduct that transports surface water from ..
  37. pmc An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria
    C Diorio
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    J Bacteriol 177:2050-6. 1995
    ..This chromosomal operon was cloned, sequenced, and found to consist of three cistrons which we named arsR, arsB, and arsC because of their strong homology to plasmid-borne ars operons...
  38. ncbi Evaluation of 18F-CPFPX, a novel adenosine A1 receptor ligand: in vitro autoradiography and high-resolution small animal PET
    Andreas Bauer
    Institute of Medicine, Research Center Julich, Juelich, Germany
    J Nucl Med 44:1682-9. 2003
    Adenosine modulates brain activity through 4 G protein-coupled receptors, primarily adenosine A(1) receptors (A(1)ARs)...
  39. pmc Gamma interferon enhances internalization and early nonoxidative killing of Salmonella enterica serovar Typhimurium by human macrophages and modifies cytokine responses
    Melita A Gordon
    Wellcome Trust Tropical Centre, Block E, Royal Infirmary Complex, 70 Pembroke Place, Liverpool L69 3GF, UK
    Infect Immun 73:3445-52. 2005
    ..release during phagocytosis of Salmonella enterica serovar Typhimurium by human monocyte-derived macrophages (MDM)...
  40. pmc The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex
    Gopal P Patel
    Department of Molecular and Cellular Biology, University of Guelph Guelph, Ontario, Canada, N1G 2W1
    Nucleic Acids Res 33:7074-89. 2005
    ..protein (PABP) mRNA translation involves the binding of PABP to the adenine-rich autoregulatory sequence (ARS) in the 5'-untranslated region of its own mRNA...
  41. doi The influence of age and Rhodococcus equi infection on CD1 expression by equine antigen presenting cells
    Indira S Pargass
    Department of Veterinary Clinical Sciences, Washington State University, College of Veterinary Medicine, P O Box 646610, Pullman, WA 99164 6610, USA
    Vet Immunol Immunopathol 130:197-209. 2009
    ..equi induces up-regulation of CD1 on both adult and perinatal APC. CD1 expression was examined by flow cytometric analysis using a panel of monoclonal CD1 antibodies with different species and isoform specificities...
  42. ncbi Differential coupling of glucagon and beta-adrenergic receptors with the small and large forms of the stimulatory G protein
    T Yagami
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Mol Pharmacol 48:849-54. 1995
    Glucagon receptors (GRs) and beta-adrenergic receptors (beta-ARs) stimulate adenylate cyclase (AC) via Gs. The present study was performed to determine whether different cAMP-generating receptors share the same pool of Gs...
  43. ncbi Immunohistochemical expression of P53 and oncogenes in ulcerative colitis-associated colorectal carcinoma
    Matthias Bruwer
    Department of General Surgery, University of Munster, Waldeyerstrasse 1, Munster 48149, Germany
    World J Surg 26:390-6. 2002
    The role of the tumor suppressor gene p53 and proto-oncogenes mdm-2, waf-1,and bcl-2 in sporadic colorectal carcinoma (CRC) has been well investigated...
  44. ncbi Epidemiologic analysis of maternal factors and amniotic band defects
    Martha M Werler
    Slone Epidemiology Center, Boston University School of Public Health, Boston, Massachusetts 02215, USA
    Birth Defects Res A Clin Mol Teratol 67:68-72. 2003
    The group of defects identified as amniotic bands includes amnion rupture sequence (ARS) and body wall complex (BWC)...
  45. pmc Up-regulation of A 2B adenosine receptor in A 2A adenosine receptor knockout mouse coronary artery
    Bunyen Teng
    Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, Morgantown, WV 26506 9104, USA
    J Mol Cell Cardiol 44:905-14. 2008
    In this study, we looked into possible compensatory changes of other adenosine receptors (ARs) in A(2A) genetic knockout mice (A2AKO) as well as the functional role of nitric oxide (NO) in A(2A) AR-mediated vasodilation...
  46. pmc A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors
    Kaizheng Gong
    Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China
    J Biol Chem 283:29028-36. 2008
    ..crucial role in various physiological and pathological processes mediated by beta(2)-adrenergic receptors (beta(2)-ARs). However, the detailed mechanism of beta(2)-ARs-induced p38 MAPK activation has not yet been fully defined...
  47. ncbi Genomic organization and expression of the human alpha 1B-adrenergic receptor
    C S Ramarao
    Department of Heart and Hypertension Research, Cleveland Clinic Foundation, Ohio 44195
    J Biol Chem 267:21936-45. 1992
    alpha 1-Adrenergic receptors (ARs) are members of the guanine nucleotide-binding protein-coupled receptor superfamily. The genes for all ARs described thus far are intronless...
  48. pmc Disparate ligand-mediated Ca(2+) responses by wild-type, mutant Ser(200)Ala and Ser(204)Ala alpha(2A)-adrenoceptor: G(alpha15) fusion proteins: evidence for multiple ligand-activation binding sites
    P J Pauwels
    Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin 81106 Castres Cédex, France
    Br J Pharmacol 130:1505-12. 2000
    Ligand : receptor interactions were analysed at wt, mutant Ser(200)Ala and Ser(204)Ala alpha(2A) ARs by measuring Ca(2+) responses in CHO-K1 cells either by co-expression with a G(alpha15) protein or at a receptor : G(alpha15) protein ..
  49. ncbi Mutational analysis of mucopolysaccharidosis type VI patients undergoing a phase II trial of enzyme replacement therapy
    Litsa Karageorgos
    Lysosomal Diseases Research Unit, Department of Genetic Medicine, Children, Youth and Women s Health Service, North Adelaide, SA 5006, Australia
    Mol Genet Metab 90:164-70. 2007
    ..syndrome) is a lysosomal storage disorder caused by mutations in the N-acetylgalactosamine-4-sulfatase (ARSB) gene. These mutations result in a deficiency of ARSB activity...
  50. pmc Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis
    Akimasa Miyanaga
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 105:871-6. 2008
    ..vinelandii are synthesized by two type III polyketide synthases (PKSs), ArsB and ArsC, which are encoded by the ars operon...
  51. doi Fine-scale foraging behaviour of a medium-ranging marine predator
    K C Hamer
    Institute of Integrative and Comparative Biology, University of Leeds, Leeds LS2 9JT, UK
    J Anim Ecol 78:880-9. 2009
    ..respond to prey patches at different spatial scales, particularly through the adoption of area-restricted search (ARS) behaviour...
  52. ncbi Medicinal chemistry of adenosine A3 receptor ligands
    Christa E Muller
    Pharmaceutical Institute, University of Bonn, Germany
    Curr Top Med Chem 3:445-62. 2003
    A(3) Adenosine receptors (ARs) exhibit large species differences. Potent, selective agonists for rat (e.g. Cl-IB-MECA, 5) and human A(3) ARs (e.g. PENECA, 17, and analogs) have been developed during the past years...
  53. ncbi Polycarbonate-urethane hard segment type influences esterase substrate specificity for human-macrophage-mediated biodegradation
    Rosalind S Labow
    University of Ottawa Heart Institute, University of Ottawa, ON, Canada
    J Biomater Sci Polym Ed 16:1167-77. 2005
    ..When cultured on PCNUs, differing in their chemistries, monocyte-derived macrophages (MDM) synthesized and secreted different amounts of both cholesterol esterase (CE) and monocyte-specific esterase (MSE)...
  54. ncbi Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisinin in human plasma
    Le Thi Diem Thuy
    Cho Ray Hospital, Ho Chi Minh City, Vietnam
    Southeast Asian J Trop Med Public Health 39:963-77. 2008
    ..liquid chromatography-mass spectrometry (LC-MS) analytical method used for the co-quantification of artesunate (ARS) and its active metabolite, dihydroartemisinin (DHA), in human plasma, using artemisinin (ARN) as an internal ..
  55. pmc Regulation and expression of the arsenic resistance operon from Staphylococcus aureus plasmid pI258
    G Ji
    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago 60680
    J Bacteriol 174:3684-94. 1992
    ..The DNA sequence contains three genes in the order arsR, arsB, and arsC...
  56. ncbi Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization
    M J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, France
    J Pharmacol Exp Ther 297:876-87. 2001
    ..1) and halpha(2C)- (7.2) adrenoceptors (ARs), whereas its affinity for halpha(2B)-ARs was less marked (6.5)...
  57. ncbi Mal de Meleda: a new geographical localization in Anatolia
    S Ergin
    Department of Dermatology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Dermatology 206:124-30. 2003
    Mal de Meleda (MDM) is an autosomal recessive form of palmoplantar keratoderma first described on the Dalmatian island of Meleda...
  58. ncbi SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda
    Bertrand Favre
    Laboratory of Cutaneous Biology, Department of Dermatology, CHUV, Lausanne, Switzerland
    J Invest Dermatol 127:301-8. 2007
    b>SLURP1 is a secreted member of the LY6/PLAUR protein family. Mutations in the SLURP1 gene are the cause of Mal de Meleda (MDM), a rare autosomal recessive genetic disease, characterized by inflammatory palmoplantar keratoderma...
  59. doi Expression of alpha-AR subtypes in T lymphocytes and role of the alpha-ARs in mediating modulation of T cell function
    Jing Yin Bao
    Department of Physiology, School of Medicine and Key Laboratory of Neuroregeneration of Jiangsu Province, Nantong University, Nantong, China
    Neuroimmunomodulation 14:344-53. 2007
    Previous work in our laboratory has shown that alpha-adrenoreceptors (alpha-ARs) and beta-ARs exist on lymphocytes from functional profile, and that the receptors mediate the regulation of lymphocyte function by catecholamines...
  60. pmc Coexistence of mal de Meleda and congenital cataract in a consanguineous Tunisian family: two case reports
    Mbarka Bchetnia
    Molecular Investigation of Genetic Orphan Diseases Research Unit, Institut Pasteur de Tunis, Tunis, Tunisia
    J Med Case Rep 4:108. 2010
    ..It is characterized by diffuse erythema and hyperkeratosis of the palms and soles. Recently, mutations in the ARS (component B) gene (ARS, MIM: 606119) on chromosome 8q24.3 have been identified in families with this disorder...
  61. ncbi Elucidation of adsorption mechanism of bone-staining agent alizarin red S on hydroxyapatite by FT-IR microspectroscopy
    T Moriguchi
    Department of Chemistry, Saitama Medical School, 981 Kawakado, Moroyama machi, Iruma gun, Saitama 350 0496, Japan
    J Colloid Interface Sci 260:19-25. 2003
    To elucidate adsorption mechanism of alizarin red S (ARS), which is often used for staining bones in histology, adsorption of ARS on hydroxyapatite, Ca10(PO4)6(OH)2 (HAP), was investigated by a batch method, compared with alizarin, ..
  62. pmc Yeast telomere repeat sequence (TRS) improves circular plasmid segregation, and TRS plasmid segregation involves the RAP1 gene product
    M S Longtine
    Department of Plant Biology, University of Minnesota, St Paul 55108
    Mol Cell Biol 12:1997-2009. 1992
    ..sequences (TRSs) can dramatically improve the segregation of unstable circular autonomously replicating sequence (ARS) plasmids in Saccharomyces cerevisiae...
  63. ncbi Transcriptional regulation of the Nia1 gene encoding nitrate reductase in Chlamydomonas reinhardtii: effects of various environmental factors on the expression of a reporter gene under the control of the Nia1 promoter
    R Loppes
    Department of Plant Biology, University of Liege, Sart Tilman, Belgium
    Plant Mol Biol 41:701-11. 1999
    ..the regulation of the Nia1 gene at the transcriptional level, NR+ and NR- transformed cells harbouring the Nia1:Ars construct (Nia1 promoter fused to the arylsulfatase (ARS)-encoding Ars reporter gene) were cultivated under various ..
  64. ncbi 7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists
    S Hess
    Pharmaceutical Chemistry, Institute of Pharmacy, University of Leipzig, Bruderstrasse 34, D 04103 Leipzig, Germany
    J Med Chem 43:4636-46. 2000
    ..adenosine receptor affinity determined in radioligand binding assays at rat A(1) and A(2A) adenosine receptors (ARs). Selected compounds were additionally investigated in binding assays at recombinant A(3) ARs...
  65. ncbi Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice
    Diana T McCloskey
    Departments of Medicine and Radiology, Cardiovascular Research Institute, University of California, CA, San Francisco, USA
    J Mol Cell Cardiol 35:1207-16. 2003
    ..myocardial alpha(1)-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) to determine if alpha(1)-ARs are required for normal myocardial contraction...
  66. pmc The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel
    Tina C Wan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 324:234-43. 2008
    ..binding and cAMP accumulation assays using human embryonic kidney 293 cells expressing recombinant mouse ARs, CP-532,903 was found to bind with high affinity to mouse A(3)ARs (K(i) = 9.0 +/- 2...
  67. doi Quantitative mRNA analysis of serotonin 5-HT₄ and adrenergic β₂ receptors in the mouse embryonic telencephalon
    Melissa C Hernandez
    Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
    Dev Neurosci 32:278-87. 2010
    ..Since 5-HT₄-Rs and β₂-ARs can form homodimers and heterodimers and they increase intracellular cAMP levels, these receptors may be important ..
  68. doi Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells
    Manuel A Silva
    Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    Lab Invest 92:937-48. 2012
    ..Human monocyte-derived macrophages (MDM) were pre-treated with or without LPS, immunophenotyped, and their supernatant, as well as cytokines at levels ..
  69. doi Interaction of Androst-5-ene-3β,17β-diol and 5α-androstane-3β,17β-diol with estrogen and androgen receptors: a combined binding and cell study
    Jiong Chen
    Laboratory of Structural Biology with Visiting Scientists, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Shanghai 200031, China
    J Steroid Biochem Mol Biol 137:316-21. 2013
    ..and 3β-DIOL stimulated estrogen-dependent BC cell growth via ERs, but inhibited growth via androgen receptors (ARs). Several steroids bind to both ER and AR in a different preference and degree, i.e...
  70. doi Upregulation of α1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II
    Peter D Drummond
    Centre for Research on Chronic Pain and Inflammatory Diseases, Murdoch University, Perth, Western Australia, Australia Electronic address
    Pain 155:606-16. 2014
    ..an abnormal excitability to adrenergic agents, possibly due to an enhanced expression of α1-adrenoceptors (α1-ARs) on these nerve fibres...
  71. doi [A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome]
    Masaaki Matsushima
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 55:810-5. 2015
    ..Following this treatment, the symptoms were improved. Anti-ARS (aminoacyl t-RNA synthetase) antibodies such as anti-PL7 antibody are useful in diagnosis and for prognostic ..
  72. ncbi HIV-1 gp120 stimulates the production of beta-chemokines in human peripheral blood monocytes through a CD4-independent mechanism
    L Fantuzzi
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 166:5381-7. 2001
    ..Treatment of either freshly isolated 1-day-cultured monocytes or 7-day-cultured monocyte-derived macrophages (MDM) with recombinant gp120-IIIB resulted in a specific and dose-dependent enhancement of secretion of monocyte ..
  73. ncbi Selection of high affinity p-azophenyarsonate Fabs from heavy-chain CDR2 insertion libraries
    Behnaz Parhami-Seren
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT 05405 0068, USA
    J Immunol Methods 259:43-53. 2002
    ..length of the heavy chain complementarity-determining region two (HCDR2) of the unmutated anti-p-azophenylarsonate (Ars) monoclonal antibody (36-65 mAb) was extended by three residues in order to test whether this insertion can provide ..
  74. ncbi Perturbation of cell cycle regulators in Peyronie's disease
    J P Mulhall
    Andrology Research Laboratory, VA Hospital, Hines and Department of Urology, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois, USA
    Int J Impot Res 13:S21-8. 2001
    ..This study was undertaken to study the presence and function of p53 and its downstream elements (p21, mdm-2) in Peyronie's disease cell cultures...
  75. ncbi HIV-1 down-modulates gamma signaling chain of Fc gamma R in human macrophages: a possible mechanism for inhibition of phagocytosis
    Katherine Kedzierska
    AIDS Pathogenesis Research Unit, Macfarlane Burnet Center, Victoria, Australia
    J Immunol 168:2895-903. 2002
    ..FcgammaR-mediated phagocytosis by human monocyte-derived macrophages (MDM) is inhibited by HIV-1 infection in vitro, and the underlying mechanism was investigated in this study...
  76. ncbi Alveolar recruitment strategy increases arterial oxygenation during one-lung ventilation
    Gerardo Tusman
    Department of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, Argentina
    Ann Thorac Surg 73:1204-9. 2002
    ..A previous report demonstrated that an alveolar recruitment strategy (ARS) improves lung function during general anesthesia in supine patients...
  77. ncbi Severe immune dysfunction after lethal neutron irradiation in a JCO nuclear facility accident victim
    Hitomi Nagayama
    Institute of Medical Science, University of Tokyo, Japan
    Int J Hematol 76:157-64. 2002
    The optimal treatment for the hematological toxicity of acute radiation syndrome (ARS) is not fully established, especially in cases of high-dose nonuniform irradiation by mixed neutrons and gamma-rays, because estimation of the ..
  78. ncbi Lung recruitment improves the efficiency of ventilation and gas exchange during one-lung ventilation anesthesia
    Gerardo Tusman
    Department of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, Argentina
    Anesth Analg 98:1604-9, table of contents. 2004
    ..We studied the effect of an alveolar recruitment strategy (ARS) on gas exchange and lung efficiency during OLV by using the single-breath test of CO(2) (SBT-CO(2))...
  79. ncbi Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells
    Maqsood A Chotani
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
    Am J Physiol Heart Circ Physiol 288:H69-76. 2005
    The physiological role of alpha(2)-adrenoceptors (alpha(2)-ARs) in cutaneous, arteriolar, vascular smooth muscle cells (VSMs) is to mediate cold-induced constriction...
  80. ncbi Transformation of Mucor circinelloides with autoreplicative vectors containing homologous and heterologous ARS elements and the dominant Cbx(r) carboxine-resistance gene
    R Ortiz-Alvarado
    Instituto de Investigacion en Biologia Experimental, Facultad de Quimica, Universidad de Guanajuato, Noria Alta s n, Apartado Postal 187, Guanajuato, Gto, 36000, Mexico
    Curr Microbiol 52:178-81. 2006
    ..with plasmid constructs containing homologous leuA gene and adjacent autonomously replicating sequences (ARS) element combined with the Cbx(r)(carboxine-resistance) gene of Ustilago maydis and ARS sequences from this ..
  81. ncbi Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation
    Eric E Lloyd
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, MS A 601, Baylor College of Medicine, 6565 Fannin St, Houston, TX 77030, United States
    Atherosclerosis 192:49-55. 2007
    ..lipid metabolism at the levels of lipid synthesis and gene expression in THP-1 monocyte derived macrophages (MDM)...
  82. ncbi [Study on the interaction of hemoglobin and Cu(II)-ARS complex]
    Xiao Hua Wu
    College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China
    Guang Pu Xue Yu Guang Pu Fen Xi 27:1168-71. 2007
    The reaction of hemoglobin (Hb) with copper(II)-Alizarin red S (ARS) complex was studied in H3PO4-KH2PO4 buffer solution (pH 4. 2) by ultraviolet-visible spectrophotometry...
  83. pmc Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk
    W James Waldman
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Brain Behav Immun 22:215-23. 2008
    ..HUVEC were stimulated by soluble factors induced by EBV dUTPase-treated monocyte-derived macrophages (MDM) that resulted in the upregulation of VCAM-1 and ICAM-1...
  84. ncbi Minor polar compounds extra-virgin olive oil extract (MPC-OOE) inhibits NF-kappa B translocation in human monocyte/macrophages
    Sandra Brunelleschi
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, Via Solaroli 17, 28100 Novara, Italy
    Pharmacol Res 56:542-9. 2007
    ..rich in MPC and prepared by some of us, on NF-kappaB translocation in monocytes and monocyte-derived macrophages (MDM) isolated from healthy volunteers...
  85. pmc Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
    Fatma Z Guerfali
    Laboratoire d Immuno pathologie, Vaccinologie et Génétique Moléculaire, WHO Collaborating Center for Research and Training in Leishmaniasis, Institut Pasteur de Tunis, 13 Place Pasteur, BP 74, 1002 Tunis Belvedere, Tunisia
    BMC Genomics 9:238. 2008
    ..this host-parasite conflict at the transcriptional level, in the context of monocyte-derived human MPhis (MDM) infection by L...
  86. doi Hydraulic anisotropy characterization of pneumatic-fractured sediments using azimuthal self potential gradient
    DeBonne N Wishart
    Department of Earth and Environmental Sciences, Rutgers University, Newark, NJ 07102, United States
    J Contam Hydrol 103:134-44. 2009
    ..Azimuthal resistivity (ARS) measurements were also made for comparative purposes...
  87. pmc Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor
    Ru Quan Han
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesth Analg 108:280-7. 2009
    ..We used beta(2)AR knockout mice and a beta(2) selective antagonist to test the effect of loss of beta(2)ARs on outcome from transient focal cerebral ischemia.
  88. doi Amelioration of cardiac remodeling in congestive heart failure by beta-adrenoceptor blockade is associated with depression in sympathetic activity
    Jarmila Machackova
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Winnipeg, Canada
    Cardiovasc Toxicol 10:9-16. 2010
    ..The results indicate that the beneficial effects of beta-AR antagonists on cardiac remodeling and heart dysfunction in CHF may be due to the blockade of beta-ARs in the myocardium and a depression in the sympathetic activity.
  89. ncbi Identification of cysteine-rich epidermal growth factor-like domain 1alpha (CRELD1alpha) as a novel alpha1A-adrenoceptor-down-regulating protein and establishment of an alpha1L-adrenoceptor-expressing cell line
    Atsushi Nishimune
    Division of Pharmacology, Department of Biochemistry and Bioinformative Sciences, School of Medicine, University of Fukui, Eiheiji, Fukui, Japan
    J Pharmacol Sci 113:169-81. 2010
    Two distinct alpha(1)-adrenoceptor phenotypes (alpha(1A)- and alpha(1L)-ARs) are known to originate from a single ADRA1A(alpha(1a)) gene by an as-yet-unknown mechanism...
  90. doi Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype
    Tatiana L Fonseca
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Bone Miner Res 26:591-603. 2011
    ..By immunohistochemistry, we detected α(2A)-, α(2B)-, α(2C)- and β(2)-ARs in osteoblasts, osteoclasts, and chondrocytes of 18.5-day-old mouse fetuses and 35-day-old mice...
  91. pmc Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident
    Sergiy V Klymenko
    Institute of Clinical Radiology, Duke University Medical Center, Durham, NC, USA
    Int J Radiat Biol 87:846-50. 2011
    ..The diagnosis of acute radiation syndrome (ARS) was confirmed in 134 individuals exposed to high levels of radiation...
  92. doi Transcriptional analysis of antibiotic resistance and virulence genes in multiresistant hospital-acquired MRSA
    Mireille Pruneau
    Departement de Biologie, Centre d étude et de valorisation de la diversité microbienne, Faculte des Sciences, Universite de Sherbrooke, QC, Canada
    FEMS Immunol Med Microbiol 63:54-64. 2011
    ..Genes encoding efflux pumps (norA, arsB, emrB) and the macrolide resistance gene ermA were found to be commonly expressed by HA-MRSA strains, but not in ..
  93. doi Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro
    Christel Björk
    Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Malmo, Sweden
    Reprod Toxicol 32:293-7. 2011
    ..CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively...
  94. ncbi Humphrey visual fields and optical coherence tomography findings in patients with the Axenfeld-Rieger syndrome: a case series
    Luis A Santiago-Cabán
    Department of Ophthalmology, University of Puerto Rico Medical Sciences Campus, Ponce, PR
    Bol Asoc Med P R 102:9-14. 2010
    ..Previous studies have reported that the Axenfeld-Rieger syndrome (ARS) occurs in one out of 200,000 patients.
  95. doi CAG repeat polymorphism in androgen receptor gene is not directly associated with polycystic ovary syndrome but influences serum testosterone levels
    L Skrgatić
    Department of Obstetrics and Gynaecology, University of Zagreb Medical School, Division of Human Reproduction, University Medical Centre Zagreb, Petrova 13, Zagreb, Croatia
    J Steroid Biochem Mol Biol 128:107-12. 2012
    ..Androgens exert their effects through androgen receptors (ARs)...
  96. pmc Alpha-1 adrenergic receptors gate rapid orientation-specific reduction in visual discrimination
    Mario Treviño
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    Cereb Cortex 22:2529-41. 2012
    ..visual stimulation combined with systemic activation of alpha-1 adrenergic neuromodulator receptors (α(1)-ARs) leads to a rapid, reversible, and NMDAR-dependent depression of AMPAR-mediated transmission from ascending inputs ..
  97. doi Alveolar recruitment improves ventilation during thoracic surgery: a randomized controlled trial
    C Unzueta
    Department of Anesthesiology, Hospital de Sant Pau, Barcelona, Spain
    Br J Anaesth 108:517-24. 2012
    This study was conducted to determine whether an alveolar recruitment strategy (ARS) applied during two-lung ventilation (TLV) just before starting one-lung ventilation (OLV) improves ventilatory efficiency.
  98. doi Reference data for bone mineral density in Swedish women using digital x-ray radiometry
    Bo Arvidsson
    Department of Internal Medicine, Orebro University Hospital, Orebro, Sweden
    J Clin Densitom 16:183-8. 2013
    ..Microdose mammography was used (Sectra MDM L30; Sectra Imtec AB, Linköping, Sweden) to measure BMD. Cole's LMS method was used to calculate DXR...
  99. doi Regulation of cyclic adenosine monophosphate release by selective β2-adrenergic receptor stimulation in human terminal failing myocardium before and after ventricular assist device support
    Astrid Kassner
    Herz und Diabeteszentrum NRW, Klinik f Thorax und Kardiovaskularchirurgie, E and H Klessmann Institut f Kardiovaskuläre Forschung und Entwicklung, Bad Oeynhausen, Germany
    J Heart Lung Transplant 31:1127-35. 2012
    ..after ventricular assist device (VAD) support is associated with upregulation of β1-adrenergic receptors (β1-ARs)...
  100. pmc To charge or not to charge: mechanistic insights into neuropathy-associated tRNA synthetase mutations
    Rachel C Wallen
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA
    Curr Opin Genet Dev 23:302-9. 2013
    ..Interestingly, ARS gene mutations have been implicated in tissue-specific human diseases, including inherited peripheral neuropathies...
  101. ncbi Bioluminescent bioreporter for assessment of arsenic contamination in water samples of India
    Pratima Sharma
    Gene Expression Laboratory, Department of Biosciences, Jamia Millia Islamia University, New Delhi 110 025, India
    J Biosci 38:251-8. 2013
    In the present study the most efficient R-factor controlling the ars operon was selected after screening of 39 Escherichia coli isolates by minimum inhibitory concentration test (MIC) studies from water samples of different geographical ..

Research Grants69

  1. Vitamin D Inhibition of HIV and M. Tuberculosis Coinfection in Macrophages
    Stephen A Spector; Fiscal Year: 2010
    ..D3 (calcitriol) to improve Mtb killing and inhibit HIV infection in coinfected monocyte-derived-macrophages (MDM));and 2. Identify the mechanism(s) of vitamin D3 mediated inhibition of Mtb and HIV in coinfected macrophages...
  2. Modeling monocyte and macrophage based gene therapy for neuroAIDS
    Yuanan Lu; Fiscal Year: 2013
    ..Hence, new therapies for HAD are needed. Circulating blood monocyte-derived macrophages (MDM) are known to migrate across the BBB and to enter the CNS under both normal and certain circumstances;some ..
  3. JIALIN CHARLES ZHENG; Fiscal Year: 2014
    ..we demonstrated that glutamate is upregulated by HIV-infected, immune-activated monocyte derived macrophages (MDM) and this neurotoxic increase in glutamate represents a major contribution to macrophage-mediated neurotoxicity...
  4. Role of Host miRNAs in Persistent HIV Macrophage Infection
    Judy Lieberman; Fiscal Year: 2011
    ..8-11 fold after infection, significantly enhance the survival of uninfected monocyte-derived macrophages (MDM). Conversely, inhibition of each of these miRNAs reduces survival of HIV-infected MDM to that of uninfected MDM...
  5. In Vivo Reconstitution Models for NeuroAIDS and Beta-Amyloidosis
    Tsuneya Ikezu; Fiscal Year: 2010
    ..roles played by chronic HIV-1 infection on Aj3 synthesis and metabolism in human monocyte-derived macrophages (MDM);2) To characterize the role of persistent viral infection on beta-amyloidosis in severely compromised ..
  6. Novel Pathways of HAARTmediated Neuronal Toxicity in the Central Nervous System
    Kelly L Jordan Sciutto; Fiscal Year: 2010
    ..patients with HIV-associated neurocognitive disorders, and in cultures of neurons and monocyte derived macrophages (MDM) following treatment with HAART compounds...
  7. DENNIS LARRY KOLSON; Fiscal Year: 2015
    ..replication, b) associated inflammatory responses, and c) neurotoxin production in monocyte- derived macrophages (MDM). DMF/MMF also d) induces monocyte antioxidant responses and e) suppresses chemotaxis...
  8. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2010
    ..aims: 1) Examine the role of IL-10 in cocaine-mediated up-regulation of SHIV/HIV-1 replication in macaque/human MDM cultures, 2) To determine the mechanism(s) of cocaine &virus protein induced-CXCL10 on neuronal dysfunction/..
  9. Linda E Rivera; Fiscal Year: 2014
    ..with HIV replication and decreased levels STAT-1 phosphorylation (STAT-1PY) in monocyte-derived macrophages (MDM). However, the players and the mechanism by which this occurs are unknown...
  10. INDUCTION OF APOPTOSIS BY HIV-1 VPR
    Vicente Planelles; Fiscal Year: 2010
    ..Specific Aim 2. To explore the effect of Vpr on ATR in monocyte-derived macrophages (MDM). We have observed that MDM are refractory to Vpr-induced apoptosis, but not to other pro-apoptotic stimuli...
  11. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID...
  12. Purification &Characterization of Adenosine Receptors
    Joel M Linden; Fiscal Year: 2009
    ..liposomal clodronate, and then to reconstitute mice with monocytic RAW cells that express various numbers of A^ARs. Hypothesis 2 is that the contribution of macrophages to tissue protection will be largely dependent on their ..
  13. Mechanisms for the Transition to Castrate Resistant Prostate Cancer
    Stephen R Plymate; Fiscal Year: 2013
    ..Aim 3. Determine the role of splice variant ARs that increase following castration in the regulation of IGF-IR expression and the timing of effectiveness of ..
  14. Adenosine Receptors and Atherogenesis
    Katya Ravid; Fiscal Year: 2012
    ABSTRACT Adenosine binding to adenylyl cyclase stimulatory (A2-type) adenosine receptors (ARs) induces coronary vasodilatation, inhibits human aortic vascular smooth muscle cell proliferation, and affects arterial wall matrix production,..
  15. Chandan Guha; Fiscal Year: 2014
    ..The current proposal prepares the groundwork for a post radiation strategy to protect critical tissues affected by ARS within days after the radiation event has occurred...
  16. Diane M Robins; Fiscal Year: 2014
    ..We hypothesize that mechanisms underlying differential gene regulation by variant ARs may reveal more effective ways to combat pathological actions of the wild type AR...
  17. Stephen R Hammes; Fiscal Year: 2016
    ..in response to multiple inputs, including nongenomic androgen signaling via membrane-localized androgen receptors (ARs) as well as growth factors via Receptor Tyrosine Kinases (RTKs)...
  18. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..demonstrate whether plasma endotoxin levels as measured with Endacea's endotoxin assay and expression of A1 ARs in the lungs of rats correlate with the severity of ALI following CLP...
  19. Molecular Complementation of Nuclear Receptors
    John T Koh; Fiscal Year: 2010
    ..TR mutations;(4) develop analogs of the anti-androgen bicalutamide to restore antagonist activity towards mutant ARs that confer androgen independence in prostate cancer...
  20. Anthony J Baker; Fiscal Year: 2016
    ..downregulation of 2-responses;thus, suggesting upregulation of responses to alpha-1 adrenergic receptors (11-ARs)...
  21. Paul C Simpson; Fiscal Year: 2016
    ..The catecholamines norepinephrine (NE) and epinephrine (EPI) activate two types of ARs on cardiac muscle cells, the dominant beta-ARs, which increase heart contraction, and alpha-1-ARs, which are few in ..
  22. Citicoline Treatment of Methamphetamine Dependence
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2010
    ..We plan to receive participant referrals from Assessment and Referral Services (ARS), which provides assessments for several thousand Salt Lake County residents with substance abuse disorders and no ..
  23. S Jamal Mustafa; Fiscal Year: 2015
    ..We have shown that CASMC and E contain both A2A and A2B relaxing ARs;and CASMC and E also contain A1 and A3 contracting ARs...
  24. Mary Jane Skelly; Fiscal Year: 2014
    ..Specifically, we propose that the balanced excitatory and inhibitory effects of norepinephrine acting on BLA ARs is altered by social isolation, resulting in increased BLA excitatory output, which in turn potentiates anxiety and ..
  25. Extrinsic Neural Control of Gastrointestinal Function in the Disordered Bowel
    David R Linden; Fiscal Year: 2012
    ..Specific Aim 2 tests the hypothesis that the expression and function of 12A adrenergic receptors (ARs) on the terminal fields of PVG neurons in the ileum is increased following the onset of TNBS or acetic acid induced ..
  26. The effects of A2A adenosine receptor agonists in sepsis
    CHRISTOPHER CHARLES MOORE; Fiscal Year: 2010
    ..cells in the control of A2A AR agonist effects through the use of chimeric knock-out mice where the A2A ARs appear on only selected cells. This technique will be focused on one sepsis paradigm, i.e., endotoxemia...
  27. Paul C Simpson; Fiscal Year: 2016
    ..This project is focused on the novel idea that alpha-1A-adrenergic receptors (ARs) on cardiac myocytes comprise an endogenous adaptive signaling system that protects and repairs myocytes after ..
  28. Johannes W Hell; Fiscal Year: 2016
    ..Because ? ARs also associate with Cav1...
  29. CHRIS S HAGUE; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): ?1-adrenergic receptors (ARs) are G-protein coupled receptors (GPCRs) that respond to sympathetic hormones norepinephrine and epinephrine, and are therapeutic targets for the treatment of ..
  30. STEPHANIE FLAVIN; Fiscal Year: 2014
    ..In particular, norepinephrine signaling through [unreadable]2-adrenergic receptors ([unreadable]2 -ARs) in the BNST has been shown to modulate stress-induced reinstatement of drug-seeking behavior...
  31. Molecular and Cellular Basis of Cognitive Aging in Prefrontal Cortical Networks
    Amy F T Arnsten; Fiscal Year: 2012
    ..With advancing age, there are fewer a2A-ARs, disinhibited cAMP and increased HCN channels in the PFC...
  32. Stress-Induced Noradrenergic Dysregulation of Neuroinflammation &HPA Responses
    John D Johnson; Fiscal Year: 2013
    ..have demonstrated that production of brain IL-1 largely comes from stimulation of beta- adrenergic receptors (beta-ARs) on microglia and preliminary studies demonstrate that animals exposed to chronic stress have significantly greater ..
  33. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..The toxicity of total body irradiation (TBI) is associated with induction of acute radiation syndrome (ARS) primarily involving damage to the highly radiosensitive gastrointestinal (GI) tract and hematopoietic (HP) system...
  34. Alternative Mechanisms of Adenosine Receptor Activation
    Holger K Eltzschig; Fiscal Year: 2013
    ..the existence of endogenous non-adenosine-like compounds with biological activity on adenosine receptors (ARs). To pursue this hypothesis, we screened fractions derived from supernatants of hypoxic epithelia for AR activity...
  35. GEORGE NORBERT COX; Fiscal Year: 2015
    ..by applicant): Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID...
  36. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..PDAC) are stimulated in vitro and in vivo by cAMP-dependent signaling downstream of beta-adrenergic receptors (b-ARs) and that glucocorticoids stimulate these cells by increasing cAMP signaling...
  37. Amrita Kamat; Fiscal Year: 2016
    ..Catecholamines acting via beta-adrenergic receptors ( B-ARs) regulate lipid and glucose homeostasis...
  38. Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinases
    Sheila Collins; Fiscal Year: 2009
    ..The [unreadable]-adrenergic receptors ([unreadable]ARs) are key regulators of adipose tissue metabolism to control (i) lipolysis for mobilization of stored energy and (ii)..
  39. Development of Human, Autologous, Pluripotent Very Small Embryonic Like (VSELs) s
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ..be used to rescue the immune system of individuals suffering from the delayed effects of acute radiation syndrome (ARS)...
  40. Long-Acting G-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID...
  41. Shahab A Akhter; Fiscal Year: 2015
    ..receptor kinase-2 (GRK2), a serine-threonine kinase that phosphorylates and uncouples agonist-occupied 2-ARs, is robustly expressed in CF and GRK2 activity is significantly upregulated in chronic HF...
  42. Christie M Orschell; Fiscal Year: 2016
    ..by applicant): Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID and the U.S...
  43. GABA-B-R-mediated prevention of pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2013
    ..preliminary data show that adenylyl cyclase-dependent intracellular signaling downstream of beta-adrenoreceptors (b-ARs) stimulates PDAC while additionally triggering the release of epidermal growth factor, vascular endothelial growth ..
  44. Glutamine Transporters SNAT1 and SNAT2 in Rett Syndrome Microglia
    Izumi Maezawa; Fiscal Year: 2013
    ..We previously reported that MeCP2-deficient microglia (MDM) cause excitotoxicity by constitutively releasing five times more glutamate than wild-type microglia, thus damaging ..
  45. SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2016
    ..by applicant): Though the secreted Ly6/urokinase type plasminogen activator receptor (uPAR) related protein-1 (Slurp1) is one of the most abundantly expressed proteins in the cornea and is secreted into the tear film, its biological ..
  46. Role of CYP P450s in the Regulation of Vascular Tone through Adenosine Receptors
    S Jamal Mustafa; Fiscal Year: 2013
    ..Findings from these studies can lead to better understanding of the signaling pathways for the regulation of VT by ARs involving endothelium, CYP450s, EETs, 20-HETE, PKC, ERK1/ERK2 kinases and KATP channels...
  47. Chronic Rhinosinusitis Integrative Studies Program (CRISP)
    Robert P Schleimer; Fiscal Year: 2013
    ..population have nasal and sinus symptoms;some of these patients are diagnosed with allergic rhinitis or episodes of ARS (symptoms for 7d to 4wk, to eliminate patients with the common cold);some of these patients progress to CRS with ..
  48. Elena V Semina; Fiscal Year: 2015
    ..Mutations in PITX2 result in Axenfeld-Rieger syndrome (ARS) associated with developmental glaucoma and other systemic defects...
  49. BRENDA LYNN BOHNSACK; Fiscal Year: 2016
    ..cornea, iris, and iridocorneal angle result from anterior segment dysgenesis and include Axenfeld-Rieger Syndrome (ARS) and primary congenital glaucoma (PCG)...
  50. Beclomethasone post exposure therapy for gastrointestinal acute radiation syndrom
    Oreola Donini; Fiscal Year: 2013
    ..therapy having the potential to mitigate the gastrointestinal (GI) injury associated with acute radiation syndrome (ARS) following exposure to intense ionizing radiation...
  51. MOLECULAR MECHANISMS AND MODULATION OF GLIAL ACTIVATION
    Linda Van Eldik; Fiscal Year: 2009
    ..PERFORMANCE S1TE(S) (organization, city, state) Baylor College of Medicine USDA/ARS Children's Nutrition Research Center Houston, TX Southwest Foundation for Biomedical Research San Antonio, TX ..
  52. Mycotoxins and Birth Defects: A Global Health Concern?
    Janee Gelineau van Waes; Fiscal Year: 2010
    ..The project involves a collaborative effort between investigators at Creighton University, Duke University, USDA-ARS and CIENSA in Guatemala...
  53. Skin Stem Cells in Combined Radiation Injury
    Nelson J Chao; Fiscal Year: 2012
    ..Radiation doses of 2 Gy or more can lead to acute radiation syndrome (ARS) but would not be considered life threatening unless that exposure occurred with simultaneous physical trauma or ..
  54. Organismal Radioprotection Through Pharmacological Quiescence
    JAY COPELAND STRUM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Syndrome (ARS), including a lethal myelosuppression due to the sensitivity of proliferating hematopoietic stem/progenitor cells (HSPCs) to ionizing radiation (IR)...
  55. Oral Agents to Stimulate Neutrophil Production
    SUSAN PARK PERRINE; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The Acute Radiation Syndrome (ARS), also referred to as Acute Radiation Sickness, is an acute illness caused by irradiation of the entire, or a ..
  56. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
    ..first study to show TRPV4 involvement in a model of IBD and the first study to relate the analgesic effects of 12-ARs to decreased TRPV4 phosphorylation...
  57. Tsutomu Kume; Fiscal Year: 2014
    ..Mutations in human FOXC1 are associated with autosomal-dominant Axenfeld-Rieger Syndrome (ARS), a disorder characterized by anterior segment defects, glaucoma and other extraocular anomalies...
  58. Development of Cysteamine as a Medical Radiation Countermeasure
    John L Zenk; Fiscal Year: 2010
    ..of an improvised nuclear device would expose hundreds of thousands of citizens to acute radiation syndrome (ARS), which untreated leads to death...
  59. A Role for Mena in the Heart
    Burns C Blaxall; Fiscal Year: 2012
    ..cardiovascular biology regarding the cardiac role of Mena and its potential interactions with and regulation by 2-ARs.Heart failure is a debilitating disease with poor prognosis...
  60. LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALE
    Reginald Valdez; Fiscal Year: 1999
    ..D. from Washington State University in 1988. He is a research leader in the Animal Disease Research Unit, ARS/USDA. Dr. Knowles has funding from the Office of International Cooperative Development until September 1997...
  61. A Study of DNA Replication Origins by Comparative Functional Genomics
    Ivan Liachko; Fiscal Year: 2012
    ..I propose to isolate functional ARS sequences from different yeast species and, using comparative genomics, study the molecular determinants of ARS ..
  62. NEGATIVE SELECTION OF AUTOREACTIVE ANTIBODIES
    TIMOTHY L MANSER; Fiscal Year: 2012
    ..VH transgenic mice that express B cell antigen receptors (BCRs) with affinity for both the hapten arsonate (Ars) and intracellular autoantigens...
  63. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..molecule, L-97-1, is a water-soluble small molecule with high affinity and high selectivity (versus other human ARs) for the human A1 AR...
  64. Megakaryocyte Chemokines & Post-Irradiation Thrombocytopenia
    Mortimer Poncz; Fiscal Year: 2009
    ..The efficacy of blocking PF4 in RIT when instituted at various time after the onset of acute radiation syndrome (ARS) and the ability to improve mortality at various radiation exposures will be followed...
  65. Novel Treatment for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2004
    ..Endacea estimates that there were 1.2 million cases of Gram-negative septicemia in 2000 worldwide with a potential market size of $3.8 billion worldwide. ..
  66. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2007
    ..Moreover, LPS binds to and activates A1 ARs on human pulmonary artery endothelial cells to induce the release of substances which are cytotoxic to endothelial ..
  67. MONOCYTE/MACROPHAGE FREE RADICAL BIOLOGY ASSESSED BY EPR
    Bradley Britigan; Fiscal Year: 1993
    ..we found no evidence that neutrophils (PMNs) or mononuclear phagocytes (monocytes or monocyte-derived macrophages [MDM]) generated OH in the absence of exogenous iron...
  68. CXC Chemokines and HIV Pathogenesis
    DAVID MARKOVITZ; Fiscal Year: 2004
    ..Oncogene-alpha (GRO-alpha), is markedly stimulated following exposure of monocyte-derived macrophages (MDM) to HIV, consistent with our observation that IL-8 expression in the lymphatics of HIV-infected patients correlates ..