Gene Symbol: SLPI
Description: secretory leukocyte peptidase inhibitor
Alias: ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4, antileukoproteinase, HUSI-1, WAP four-disulfide core domain protein 4, mucus proteinase inhibitor, protease inhibitor WAP4, secretory leukocyte protease inhibitor (antileukoproteinase), seminal proteinase inhibitor
Species: human
Products:     SLPI

Top Publications

  1. Tseng C, Tseng C. Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement. FEBS Lett. 2000;475:232-6 pubmed
    Previous studies have suggested that human salivary secretory leukocyte protease inhibitor (SLPI) inhibits HIV-1 by binding to a host cell surface protein of unknown identity...
  2. Shine N, Wang S, Konopka K, Burks E, Duzgunes N, Whitman C. Secretory leukocyte protease inhibitor: inhibition of human immunodeficiency virus-1 infection of monocytic THP-1 cells by a newly cloned protein. Bioorg Chem. 2002;30:249-63 pubmed
    The ability of the salivary protein, secretory leukocyte protease inhibitor (SLPI), to inhibit human immunodeficiency virus-1 (HIV-1) infection in vitro has been reported previously and has led to the suggestion that SLPI may be partially ..
  3. Greene C, McElvaney N, O Neill S, Taggart C. Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells. Infect Immun. 2004;72:3684-7 pubmed
    Secretory leucoprotease inhibitor (SLPI) is an anti-inflammatory antiprotease which can inhibit lipopolysaccharide-induced NF-kappaB activation...
  4. Jana N, Gray L, Shugars D. Human immunodeficiency virus type 1 stimulates the expression and production of secretory leukocyte protease inhibitor (SLPI) in oral epithelial cells: a role for SLPI in innate mucosal immunity. J Virol. 2005;79:6432-40 pubmed
    ..We further hypothesized that secretory leukocyte protease inhibitor (SLPI), a 12-kDa mucosal antiviral protein, is a component of the host immune response to this virus...
  5. Kazmi S, Naglik J, Sweet S, Evans R, O Shea S, Banatvala J, et al. Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids. Clin Vaccine Immunol. 2006;13:1111-8 pubmed
    ..whole saliva with antibodies raised against human lactoferrin (hLf), secretory leukocyte protease inhibitor (SLPI), and, to a lesser extent, MG2 (high-molecular-weight mucinous glycoprotein) reduced the HIV-1 inhibitory activity ..
  6. Chotirmall S, Greene C, Oglesby I, Thomas W, O Neill S, Harvey B, et al. 17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor. Am J Respir Crit Care Med. 2010;182:62-72 pubmed publisher
    ..These data implicate a novel anti-inflammatory mechanism for E(2) in females with CF, which predisposes to infection and colonization. This could, in part, account for the observed gender dichotomy in CF. ..
  7. Thompson R, Ohlsson K. Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proc Natl Acad Sci U S A. 1986;83:6692-6 pubmed
    ..The affinity of the inhibitor for leukocyte elastase is very high, suggesting a functional role for the protein in preventing elastase-mediated damage to oral and possibly other mucosal tissues. ..
  8. Wahl S, McNeely T, Janoff E, Shugars D, Worley P, Tucker C, et al. Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I. Oral Dis. 1997;3 Suppl 1:S64-9 pubmed
    ..these observations, we recently identified an endogenous 12 kD protein, secretory leukocyte protease inhibitor (SLPI), in saliva which blocks HIV-1 infection in vitro...
  9. Pillay K, Coutsoudis A, Agadzi Naqvi A, Kuhn L, Coovadia H, Janoff E. Secretory leukocyte protease inhibitor in vaginal fluids and perinatal human immunodeficiency virus type 1 transmission. J Infect Dis. 2001;183:653-6 pubmed
    ..In 60 HIV-1-infected women, concentrations of the innate mucosal protein, secretory leukocyte protease inhibitor (SLPI), were lower in vaginal fluid samples from 17 women whose babies became infected than in samples from ..

More Information

Publications125 found, 100 shown here

  1. Jacobsen L, Sørensen O, Cowland J, Borregaard N, Theilgaard Monch K. The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils. J Leukoc Biol. 2008;83:1155-64 pubmed publisher
    The secretory leukocyte protease inhibitor (SLPI) re-establishes homeostasis at sites of infection by virtue of its ability to exert antimicrobial activity, to suppress LPS-induced cellular immune responses, and to reduce tissue damage ..
  2. Sallenave J, Ryle A. Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. Biol Chem Hoppe Seyler. 1991;372:13-21 pubmed
    ..inhibitor (ESI) was purified from sputum of patients with chronic bronchitis and compared with mucus proteinase inhibitor (MPI, BrI) isolated, without the use of affinity chromatography on an enzyme, from non-purulent sputum ..
  3. Eisenberg S, Hale K, Heimdal P, Thompson R. Location of the protease-inhibitory region of secretory leukocyte protease inhibitor. J Biol Chem. 1990;265:7976-81 pubmed
    Secretory leukocyte protease inhibitor (SLPI) is a two-domain protein that inhibits a wide range of proteases including chymotrypsin, leukocyte elastase, and trypsin...
  4. Baqui A, Meiller T, Falkler W. Enhanced secretory leukocyte protease inhibitor in human immunodeficiency virus type 1-infected patients. Clin Diagn Lab Immunol. 1999;6:808-11 pubmed
    Secretory leukocyte protease inhibitor (SLPI) has been found to possess activity against the human immunodeficiency virus type 1 (HIV-1) in vitro at physiological concentrations...
  5. Hocini H, Becquart P, Bouhlal H, Adle Biassette H, Kazatchkine M, Belec L. Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers. Clin Diagn Lab Immunol. 2000;7:515-8 pubmed
    ..These observations indicate that the inhibitory effect of SLPI is restricted to free HIV-1 in corporal fluids.
  6. Sehnert B, Cavcic A, Böhm B, Kalden J, Nandakumar K, Holmdahl R, et al. Antileukoproteinase: modulation of neutrophil function and therapeutic effects on anti-type II collagen antibody-induced arthritis. Arthritis Rheum. 2004;50:2347-59 pubmed
    b>Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases...
  7. Farquhar C, VanCott T, Mbori Ngacha D, Horani L, Bosire R, Kreiss J, et al. Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk. J Infect Dis. 2002;186:1173-6 pubmed
    Secretory leukocyte protease inhibitor (SLPI), a protein found in saliva, breast milk, and genital secretions, is capable of inhibiting human immunodeficiency virus (HIV) type 1 in vitro...
  8. Singh D, Arya P, Sharma A, Dobhal M, Gupta R. Modulatory potential of α-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats. J Ethnopharmacol. 2015;161:186-93 pubmed publisher
    ..GGT), aspartate and alanine transaminases (AST, ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), acid phosphatase (ACP), sorbitol dehydrogenase (SDH), glutamate dehydrogenase (GDH), and total bilirubin, total ..
  9. Khushboo M, Murthy M, Devi M, Sanjeev S, Ibrahim K, Kumar N, et al. Testicular toxicity and sperm quality following copper exposure in Wistar albino rats: ameliorative potentials of L-carnitine. Environ Sci Pollut Res Int. 2018;25:1837-1862 pubmed publisher
    ..65 vs 48.08 IU/L), AST (156.82 vs 88.25 IU/L), ALP (230.54 vs 148.16 IU/L), urea (12.65 vs 7.45 mmol/L), and creatinine (80.61 vs 48...
  10. Veronesi M, Bolis B, Faustini M, Rota A, Mollo A. Biochemical composition of fetal fluids in at term, normal developed, healthy, viable dogs and preliminary data from pathologic littermates. Theriogenology. 2018;108:277-283 pubmed publisher
    ..aminotransferase (AST), total bilirubin, lactate dehydrogenase (LDH), creatine-kinase (CK), alkaline phosphatase (ALP), creatinine, urea, amylase, lipase, gamma-glutamyl transferase (?-GT), triglycerides, cholesterol, total proteins, ..
  11. Zhong W, Qian K, Xiong J, Ma K, Wang A, Zou Y. Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-?B related signaling. Biomed Pharmacother. 2016;83:302-313 pubmed publisher
    ..curcumin regulated serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), accelerated liver antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and ..
  12. Das M, Basu S, Banerjee B, Sen A, Jana K, Datta G. Hepatoprotective effects of green Capsicum annum against ethanol induced oxidative stress, inflammation and apoptosis in rats. J Ethnopharmacol. 2018;227:69-81 pubmed publisher
    ..Serum levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphate (ALP), triglyceride (TG), total cholesterol (CHLS), high density lipoprotein (HDL), low density lipoprotein (LDL) very ..
  13. Yan J, Ai G, Zhang X, Xu H, Huang Z. Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats. J Ethnopharmacol. 2015;172:202-13 pubmed publisher
    ..Meanwhile, the serum levels of alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), total bilirubin (TBIL), direct bilirubin (DBIL), and total bile acid (TBA) were ..
  14. Yorsin S, Kanokwiroon K, Radenahmad N, Jansakul C. Effects of Kaempferia parviflora rhizomes dichloromethane extract on vascular functions in middle-aged male rat. J Ethnopharmacol. 2014;156:162-74 pubmed publisher
    ..were found between the KPD treated-, and the vehicle-control for animal food intake, internal organ weight, serum ALP, SGOT, SGPT, BUN and creatinine levels, serum cholesterol, HDL-C and LDL-C levels, nor total blood cell counts...
  15. Uttra A, Alamgeer -, Shahzad M, Shabbir A, Jahan S, Bukhari I, et al. Ribes orientale: A novel therapeutic approach targeting rheumatoid arthritis with reference to pro-inflammatory cytokines, inflammatory enzymes and anti-inflammatory cytokines. J Ethnopharmacol. 2019;237:92-107 pubmed publisher
    ..arthritic score, body weight, and hematological (WBC, RBC, ESR, Hb and Platelet count) and biochemical (AST, ALT, ALP, urea, creatinine, CRP and RF) parameters were observed...
  16. Ulla A, Alam M, Sikder B, Sumi F, Rahman M, Habib Z, et al. Supplementation of Syzygium cumini seed powder prevented obesity, glucose intolerance, hyperlipidemia and oxidative stress in high carbohydrate high fat diet induced obese rats. BMC Complement Altern Med. 2017;17:289 pubmed publisher
    ..5% w/w of diet). Oral glucose tolerance test, lipid parameters, liver marker enzymes (AST, ALT and ALP) and lipid peroxidation products were analyzed at the end of 56 days...
  17. Francis A, Ganapathy S, Palla V, Murthy P, Devasena T. Future of nano bisdemethoxy curcumin analog: guaranteeing safer intravenous delivery. Environ Toxicol Pharmacol. 2015;39:467-74 pubmed publisher
    ..blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine (Cre), albumin (Alb), total protein (TP), calcium (Ca) and phosphorus (P) using fully automated ..
  18. Seo B, Ryu H, Park Y, Huh J, Baek Y. Dual effect of WIN-34B on osteogenesis and osteoclastogenesis in cytokine-induced mesenchymal stem cells and bone marrow cells. J Ethnopharmacol. 2016;193:227-236 pubmed publisher
    ..Alkaline phosphatase (ALP) activity was evaluated and Von Kossa staining was conducted...
  19. Kanbur M, Siliğ Y, Eraslan G, Karabacak M, Soyer Sarıca Z, Şahin S. The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats. Environ Sci Pollut Res Int. 2016;23:5232-42 pubmed publisher
    ..BUN), creatinine, asparatate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein, albumin) in blood/tissues (liver, kidney, brain, spleen and testis) and hepatic drug-metabolising (..
  20. El Newary S, Shaffie N, Omer E. The protection of Thymus vulgaris leaves alcoholic extract against hepatotoxicity of alcohol in rats. Asian Pac J Trop Med. 2017;10:361-371 pubmed publisher
    ..showed hepatocytes distortion represented as marked increment on liver biomarkers; alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT) activities, as well as pronounced reduction on total ..
  21. Shaban N, Talaat I, Elrashidy F, Hegazy A, Sultan A. Therapeutic Role of Punica Granatum (Pomegranate) Seed Oil Extract on Bone Turnover and Resorption Induced in Ovariectomized Rats. J Nutr Health Aging. 2017;21:1299-1306 pubmed publisher
    ..Bone markers (BMs) especially osteocalcin (BGP), alkaline phosphatase (ALP), tartarate resistance acid phosphatase (TRAcP), bone weight, bone calcium concentration, serum electrolytes (..
  22. Sadeeshkumar V, Duraikannu A, Ravichandran S, Fredrick W, Sivaperumal R, Kodisundaram P. Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Biomed Pharmacother. 2016;84:1810-1819 pubmed publisher
    ..of serum liver marker enzymes namely aspartate trasaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), ?-fetoprotein (AFP) and total bilirubin along with ..
  23. Schemitt E, Hartmann R, Colares J, Licks F, Salvi J, Marroni C, et al. Protective action of glutamine in rats with severe acute liver failure. World J Hepatol. 2019;11:273-286 pubmed publisher
    ..integrity analysis [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)]...
  24. Abdullah -, Khan M, Ahmad W, Ahmad M, Nisar M. Hepatoprotective effect of the solvent extracts of Viola canescens Wall. ex. Roxb. against CCl4 induced toxicity through antioxidant and membrane stabilizing activity. BMC Complement Altern Med. 2017;17:10 pubmed publisher
    ..and partially purified EAF (90% EAF and EAF?+?Me) at 50 mg/kg body weight significantly reduced the level of ALT, ALP, total bilirubin and restored the level of serum protein in comparison to CCl4 treated group...
  25. Bakr R, El Naa M, Zaghloul S, Omar M. Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity. BMC Complement Altern Med. 2017;17:52 pubmed publisher
    ..Liver function tests; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT) and total bilirubin were performed...
  26. Rochon E, Wright D, Schubert M, Roman B. Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations. Cardiovasc Res. 2015;107:143-52 pubmed publisher
    Notch and activin receptor-like kinase 1 (ALK1) have been implicated in arterial specification, angiogenic tip/stalk cell differentiation, and development of arteriovenous malformations (AVMs), and ALK1 can cooperate with Notch to up-..
  27. Luo Z, Deng Y, Zhang R, Wang M, Bai Y, Zhao Q, et al. Peptide-laden mesoporous silica nanoparticles with promoted bioactivity and osteo-differentiation ability for bone tissue engineering. Colloids Surf B Biointerfaces. 2015;131:73-82 pubmed publisher
    ..the peptide-laden MSNs (p-MSNs) show higher MG-63 cell proliferation, spreading and alkaline phosphatase (ALP) activity than the bare MSNs, indicating good in vitro cytocompatibility...
  28. Ishikawa M, Williams G, Ikeuchi T, Sakai K, Fukumoto S, Yamada Y. Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns. J Cell Sci. 2016;129:1018-30 pubmed publisher
    ..Panx3 promoted expression of osteogenic proteins such as ALP and Ocn (also known as ALPL and BGLAP, respectively), as well as Cx43, by regulating Osx (also known as SP7) ..
  29. Na W, Liu S, Liu X, Su X. Ultrasensitive detection of amifostine and alkaline phosphatase based on the growth of CdS quantum dots. Talanta. 2015;144:1059-64 pubmed publisher
    ..reported a simple and sensitive fluorescence nanosensor for rapid detection of amifostine and alkaline phosphatase (ALP). The novel nanosensor was based on the fluorescence "turn on-off" of CdS quantum dots (QDs)...
  30. Clements I, Kelkar A, Garcia E, Butler J, Chen J, Folks R, et al. Prognostic significance of (123)I-mIBG SPECT myocardial imaging in heart failure: differences between patients with ischaemic and non-ischaemic heart failure. Eur Heart J Cardiovasc Imaging. 2016;17:384-90 pubmed publisher
    ..Prognostic significance of patterns of (123)I-mIBG and MPI uptake differ between IHF and NIHF subjects...
  31. Numano F, Shimizu C, Tremoulet A, Dyar D, Burns J, Printz B. Pulmonary Artery Dilation and Right Ventricular Function in Acute Kawasaki Disease. Pediatr Cardiol. 2016;37:482-90 pubmed publisher
    ..1 %); these subjects had higher median right ventricle myocardial performance index (RV MPI), higher ratio of early tricuspid inflow velocity to tricuspid annular early diastolic velocity (TV E/e'), and ..
  32. Dowa Y, Kawai M, Kanazawa H, Iwanaga K, Matsukura T, Heike T. Screening for secondary hyperparathyroidism in preterm infants. Pediatr Int. 2016;58:988-992 pubmed publisher
    ..3 ± 7.4. Fourteen infants (14.7%) had iPTH >65 pg/mL. Cut-offs for serum alkaline phosphatase (ALP) and percent tubular reabsorption rate of phosphate (%TRP) were fixed at 1300 IU/L and 93%, respectively using ..
  33. Shi F, Gao W, Tao E, Liu H, Wang S. Metabolic syndrome is a risk factor for nonalcoholic fatty liver disease: evidence from a confirmatory factor analysis and structural equation modeling. Eur Rev Med Pharmacol Sci. 2016;20:4313-4321 pubmed
    ..UN, Scr, UA, FPG, Fructosamine, TC, TG, lipoprotein alpha, HDL-C, LDL-C, ALT, AST, TP, albumin, globulins, TB, DB, ALP and GGT were measured. CFA was used to identify a latent structure of NAFLD and MS, respectively...
  34. Nongonierma A, Lalmahomed M, Paolella S, FitzGerald R. Milk protein isolate (MPI) as a source of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides. Food Chem. 2017;231:202-211 pubmed publisher
    ..release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides during hydrolysis of bovine milk protein isolate (MPI) with Neutrase 0.8L™, yielding 15 hydrolysates (H1-H15)...
  35. Nara M, Kitamura K, Yamamoto M, Nagakura R, Mitomo K, Matsunaga S, et al. Developmental mechanism of muscle-tendon-bone complex in the fetal soft palate. Arch Oral Biol. 2017;82:71-78 pubmed publisher
    ..staining of type II collagen (col II), tartrate-resistant acid phosphatase (TRAP), and alkaline phosphatase (ALP) staining were performed...
  36. Jeong S, Wang G, Choi B, Hwang Y, Kim B, Ko Y, et al. Secretory Leukocyte Protease Inhibitor (SLPI) Increases Focal Adhesion in MC3T3 Osteoblast on Titanium Surface. J Nanosci Nanotechnol. 2015;15:200-4 pubmed
    ..Secretory leukocyte protease inhibitor (SLPI) promotes cell migration, proliferation and wound healing...
  37. Liu J, Cui Y, Zhang G, Zhou X, Pang J, Wang X, et al. Association Between Dentin Matrix Protein 1 (rs10019009) Polymorphism and Ankylosing Spondylitis in a Chinese Han Population from Shandong Province. Chin Med J (Engl). 2016;129:657-64 pubmed publisher
    ..a functional analysis of rs10019009 via reverse transcription-polymerase chain reaction, alkaline phosphatase (ALP) activity in human osteosarcoma U 2 OS cells...
  38. Bique A, Kaivosoja E, Mikkonen M, Paulasto Kröckel M. Choice of osteoblast model critical for studying the effects of electromagnetic stimulation on osteogenesis in vitro. Electromagn Biol Med. 2016;35:353-64 pubmed publisher
    ..Baseline alkaline phosphatase (ALP) expression of SaOS-2 cells was high and rapidly further increased with EMF exposure, whereas ALP effects in MC3T3-..
  39. Chen Y, Bangash A, Song J, Zhong W, Wang C, Shao C, et al. Activation of CD137 signaling accelerates vascular calcification in vivo and vitro. Int J Cardiol. 2017;230:198-203 pubmed publisher
    ..Alkaline phosphatase (ALP) activity was measured by the ALP assay Kit...
  40. Ding Y, Yang H, Wang Y, Chen J, Ji Z, Sun H. Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1?-SOD2-mediated regulation of mitochondrial function. Int J Biol Sci. 2017;13:254-264 pubmed publisher
    ..Knock down of SIRT3 significantly decreased alkaline phosphatase (ALP) staining, and mRNA expression of runt-related transcription factor 2 (Runx2) and collagen type I ? 1 (Col1?1), and ..
  41. Zhao K, Wang F, Huang W, Wang X, Wu Y. Comparison of Dental Implant Performance Following Vertical Alveolar Bone Augmentation With Alveolar Distraction Osteogenesis or Autogenous Onlay Bone Grafts: A Retrospective Cohort Study. J Oral Maxillofac Surg. 2017;75:2099-2114 pubmed publisher
    ..Implant survival rate, peri-implant bone resorption, probe depth (PD), modified plaque index (mPI), and modified sulcus bleeding index (mSBI) were analyzed to evaluate implant prognosis...
  42. Kong X, Wang L, Li G, Qu X, Niu J, Tang T, et al. Mg-based bone implants show promising osteoinductivity and controllable degradation: A long-term study in a goat femoral condyle fracture model. Mater Sci Eng C Mater Biol Appl. 2018;86:42-47 pubmed publisher
    ..JDBM group show higher osteogenic factors level (BMP2, ALP and OC) in peri-implant callus tissue than PLA group...
  43. Bhowmik T, Saha P, Sarkar A, Gomes A. Evaluation of cytotoxicity of a purified venom protein from Naja kaouthia (NKCT1) using gold nanoparticles for targeted delivery to cancer cell. Chem Biol Interact. 2017;261:35-49 pubmed publisher
    ..activities of hepatic enzymes- aspartate transaminase (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and activities of antioxidant enzymes- superoxide dismutase (SOD), catalase (CAT), ..
  44. Fan J, Li N, Gong X, He L. Serum 25-hydroxyvitamin D, bone turnover markers and bone mineral density in postmenopausal women with hip fractures. Clin Chim Acta. 2018;477:135-140 pubmed publisher
    ..bone formation markers, including N-terminal extension propeptide of type-I collagen (P1NP), alkaline phosphatase (ALP) and osteocalcin(OC), bone resorption markers, including C-terminal telopeptide of type-I collagen (CTX-1), and ..
  45. Shen Y, Zhang J, Yu T, Qi C. Generation of PTEN knockout bone marrow mesenchymal stem cell lines by CRISPR/Cas9-mediated genome editing. Cytotechnology. 2018;70:783-791 pubmed publisher
    ..The expression of Id4, Runx2, ALP and PPARγ was examined by qPCR and immunocytochemistry staining. The PTEN-KO strain was identified by sequencing...
  46. Fujimoto M, Togashi Y, Matsuzaki I, Baba S, Takeuchi K, Inaba Y, et al. A case report of atypical Spitz tumor harboring a novel MLPH-ALK gene fusion with discordant ALK immunohistochemistry results. Hum Pathol. 2018;80:99-103 pubmed publisher
    ..However, the anti-ALK1 antibody, which is commonly used for the diagnosis of ALK-positive anaplastic large cell lymphoma, failed to ..
  47. Du L, Feng R, Ge S. PTH/SDF-1? cotherapy promotes proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells. Cell Prolif. 2016;49:599-608 pubmed publisher
    ..Cell-counting kit-8 (CCK8), cell migration assay, alkaline phosphatase (ALP) activity assay, alizarin red staining and RT-PCR were used to determine viability, migration and osteogenic ..
  48. Adeyemi O, Meyakno E, Akanji M. Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats. Gen Physiol Biophys. 2017;36:219-227 pubmed publisher
    ..Arsenic exposure elevated the activities of rat plasma AST, ALT, ALP and ?-GT, indicative of liver injury...
  49. Meraj M, Ali M, Ganai B, Bhat F, Ganaie H, Ahmed A. Alterations in liver marker enzymes and recovery ability of cyprinids as indicators of aquatic pollution. Environ Sci Pollut Res Int. 2017;24:19149-19158 pubmed publisher
    ..Dal and Mansbal) through GC-MS technique is scarce, and also the recovery in biochemical parameters (AST, ALT and ALP) of fish after transferring them to clean media has not been reported yet...
  50. Kim J, Lee H, Rhee D, Paton J, Pyo S. Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells. Biochim Biophys Acta Gen Subj. 2017;1861:2663-2673 pubmed publisher
    ..The effect of PLY on osteoblast differentiation was evaluated by qRT-PCR, ALP activity assay, flow cytometric analysis, and Western blotting...
  51. Tang Y, Xu Q, Peng H, Liu Z, Yang T, Yu Z, et al. The role of vascular peroxidase 1 in ox-LDL-induced vascular smooth muscle cell calcification. Atherosclerosis. 2015;243:357-63 pubmed publisher calcification, as demonstrated via increased mineralization, as well as increased alkaline phosphatase (ALP) activity and up-regulated runt-related transcription factor 2 (Runx2) expression in ox-LDL-treated cells...
  52. Lecchi M, Martinelli I, Zoccarato O, Maioli C, Lucignani G, Del Sole A. Comparative analysis of full-time, half-time, and quarter-time myocardial ECG-gated SPECT quantification in normal-weight and overweight patients. J Nucl Cardiol. 2017;24:876-887 pubmed publisher
    The introduction of a camera-based dose-reduction strategy in myocardial perfusion imaging (MPI) clinical setting entails the definition of objective and reproducible criteria for establishing the amount of activity to be injected...
  53. Nudi F, Schillaci O, Di Belardino N, Versaci F, Tomai F, Pinto A, et al. Temporal Trends in the Prevalence, Severity, and Localization of Myocardial Ischemia and Necrosis at Myocardial Perfusion Imaging After Myocardial Infarction. Am J Cardiol. 2017;120:1238-1244 pubmed publisher
    ..changes have impacted on the presence, severity, and localization of necrosis at myocardial perfusion imaging (MPI) has not been appraised to date. Subjects undergoing MPI and reporting a history of clinical MI were shortlisted...
  54. Chen X, Chen J, Xu D, Zhao S, Song H, Peng Y. Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs. BMC Musculoskelet Disord. 2017;18:423 pubmed publisher
    ..Forced OGN expression by OGN-infected lentivirus could increase expression of Wnt5b, RUNX2, OCN, ALP and Colla1, as well as bone formation, while decreases expression of adipogenesis marker PPAR?2...
  55. Hou Q, Huang Y, Luo Y, Wang B, Liu Y, Deng R, et al. MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR. Am J Transl Res. 2017;9:4963-4973 pubmed
    ..transfection markedly inhibited the expression of osteoblast-specific genes, such as alkaline phosphatase (ALP), collagen type II, osteopontin (OPN), and runt-related transcription factor 2 (RUNX2), which consequently ..
  56. Dong D, Yulin Z, Yan X, Hongyan Z, Shitao Z, Jia W. Enhanced expressions of lysozyme, SLPI and glycoprotein 340 in biofilm-associated chronic rhinosinusitis. Eur Arch Otorhinolaryngol. 2014;271:1563-71 pubmed
    Lysozyme, secretory leukocyte proteinase inhibitor (SLPI) and glycoprotein 340 (gp340) are important effectors of the innate immune system in sinonasal mucosa...
  57. Hao W, Zheng Y, Liu F, Wang Y, Liu Y. [Osteogenic expression of rat mesenchymal stem cell on collagen and 20?-hydroxycholesterol loaded on the apatite of titanium]. Shanghai Kou Qiang Yi Xue. 2016;25:275-80 pubmed
    ..The early osteogenic expression of BMSCs on composite layers was evaluated by alkaline phosphatase (ALP) activity. The expression of osteocalcin (OC) and collagen Type? (Col ?) was evaluated by Western blot...
  58. Mandil R, Rahal A, Prakash A, Garg S, Gangwar N, Swain D. Ameliorative potential of ?-tocopherol against flubendiamide and copper-induced testicular-insult in Wistar rats. Chem Biol Interact. 2016;260:91-101 pubmed publisher
    ..Reduced CAT activity in alone exposed groups was observed. ACP, ALP and SDH remain unaltered...
  59. Ruiz S, Zhao H, Chandakkar P, Chatterjee P, Papoin J, Blanc L, et al. A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10. Sci Rep. 2016;5:37366 pubmed publisher
    ..vascular disorder caused by loss-of-function mutations in the genes encoding activin receptor-like kinase 1 (ALK1), endoglin, Smad4, and bone morphogenetic protein 9 (BMP9)...
  60. Ravikumar K, Boda S, Basu B. Synergy of substrate conductivity and intermittent electrical stimulation towards osteogenic differentiation of human mesenchymal stem cells. Bioelectrochemistry. 2017;116:52-64 pubmed publisher
    ..Importantly, specific bone markers, in particular ALP, Col IA and Osteocalcin are expressed more significantly due to electrical stimulation, which also enhances the ..
  61. Farag A, Heo J, Tauxe L, Bhambhvani P, Germano G, Kavanagh P, et al. Detection and quantitation of right ventricular reversible perfusion defects by stress SPECT myocardial perfusion imaging: A proof-of-principle study. J Nucl Cardiol. 2019;26:266-271 pubmed publisher
    ..We hypothesized that stress/rest SPECT myocardial perfusion imaging (MPI) could detect reversible perfusion defects in the RV in some patients with LV inferior wall perfusion abnormalities...
  62. Chen J, Yu M, Guo B, Ma P, Yin Z. Conductive nanofibrous composite scaffolds based on in-situ formed polyaniline nanoparticle and polylactide for bone regeneration. J Colloid Interface Sci. 2018;514:517-527 pubmed publisher
    ..nanofibrous scaffolds on osteogenic differentiation was studied with expression levels of alkaline phosphatase (Alp), osteocalcin (Ocn) and runt-related transcription factor 2 (Runx2) during the culture of BMSCs for three weeks...
  63. Shi F, Li J, Yang L, Hou G, Ye M. Hypolipidemic effect and protection ability of liver-kidney functions of melanin from Lachnum YM226 in high-fat diet fed mice. Food Funct. 2018;9:880-889 pubmed publisher
    ..damage indices such as alanine aminotransferase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), creatinine (CRE), blood urea nitrogen (BUN) and uric acid were lowered...
  64. Sillanmäki S, Lipponen J, Tarvainen M, Laitinen T, Hedman M, Hedman A, et al. Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls. J Nucl Cardiol. 2018;: pubmed publisher
    ..Myocardial perfusion imaging (MPI) data from 994 patients were analyzed. Forty-three patient fulfilled criteria for LBBB and 24 for controls...
  65. Saber L, Mahran H, Baghdadi H, Al Hawsawi Z. Interrelationship between bone turnover markers, calciotropic hormones and leptin in obese Saudi children. Eur Rev Med Pharmacol Sci. 2015;19:4332-43 pubmed
    ..We tried to assess the association between Leptin and bone turnover markers (OCN, β-CTx, ALP), calciotropic hormones PTH and 25(OH)D in obese Saudi children...
  66. Katsikis A, Theodorakos A, Kouzoumi A, Kitziri E, Georgiou E, Koutelou M. Fast myocardial perfusion imaging with 99mTc in challenging patients using conventional SPECT cameras. J Nucl Cardiol. 2017;24:1314-1327 pubmed publisher
    We attempted to validate the performance of a fast myocardial perfusion imaging (MPI) protocol in diagnostically challenging patients. 78 patients with ΒΜΙ > 24...
  67. Ramu R, S Shirahatti P, S N, Zameer F, Lakkappa Dhananjaya B, M N N. Assessment of In Vivo Antidiabetic Properties of Umbelliferone and Lupeol Constituents of Banana (Musa sp. var. Nanjangud Rasa Bale) Flower in Hyperglycaemic Rodent Model. PLoS ONE. 2016;11:e0151135 pubmed publisher
    ..aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP); glycolytic enzyme (hexokinase); shunt enzyme (glucose-6-phosphate dehydrogenase); gluconeogenic enzymes (glucose-..
  68. Tong Y, Niu M, Du Y, Mei W, Cao W, Dou Y, et al. Aryl hydrocarbon receptor suppresses the osteogenesis of mesenchymal stem cells in collagen-induced arthritic mice through the inhibition of ?-catenin. Exp Cell Res. 2017;350:349-357 pubmed publisher
    ..The enhanced Ahr suppressed the mRNA levels of osteoblastic markers including Alkaline phosphatase (Alp) and Runt-related transcription factor 2 (Runx2) in the differentiation of MSCs to osteoblasts in CIA...
  69. Jiang J, Zhou Z, Dong Y, Gao S, Sun H, Chen Z, et al. Comparative analysis of immunocompetence between females and males in the sea cucumber Apostichopus japonicus. Fish Shellfish Immunol. 2017;63:438-443 pubmed publisher
    ..SOD), catalase (CAT), peroxidase (POD), phenoloxidase (PO), acid phosphatase (ACP) and alkaline phosphatase (ALP) with biochemical methods, the detection of PO isozymes with native-PAGE and catechol staining, and the test of ..
  70. Hung G, Ko K, Lin C, Yen R, Kao C. Impact of initial myocardial perfusion imaging versus invasive coronary angiography on outcomes in coronary artery disease: a nationwide cohort study. Eur J Nucl Med Mol Imaging. 2018;45:567-574 pubmed publisher
    ..invasive coronary angiography (CAG), or selective CAG after risk stratification using myocardial perfusion imaging (MPI). This study compared clinical outcomes between these two strategies in a large, real-world population...
  71. Qu M, Luo B, Chen H, Feng J, Gu Q. [Effects of secretory leukocyte protease inhibitor on expression of inflammation mediators in normal human bronchial epithelial cells induced by cigarette smoke extract]. Zhonghua Jie He He Hu Xi Za Zhi. 2008;31:352-5 pubmed
    To study the effect of secretory leukocyte protease inhibitor (SLPI) on the expression of MMP-9 and IL-8 in normal human bronchial epithelial (NHBE) cells induced by cigarette smoke extract (CSE), and therefore to explore the mechanisms ..
  72. Guo Y, Xu X, Zhang Q, Li C, Deng Y, Jiang P, et al. The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity. Toxicol Mech Methods. 2015;25:382-7 pubmed publisher
    ..serum biomarkers, such as aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), direct bilirubin (DBil), total bilirubin (TBil) and total bile acids (TBA)...
  73. Teixera L, de Carvalho L, de Castro O, Bastos J, Nery N, Oliveira G, et al. Local and systemic effects of BdipTX-I, a Lys-49 phospholipase A2 isolated from Bothrops diporus snake venom. Toxicon. 2018;141:55-64 pubmed publisher
    ..The systemic effects were evaluated by determining specific laboratory markers: AST, ALT, GGT, ALP, urea, creatinine, protein and calcium...
  74. Fujioka Kobayashi M, Mottini M, Kobayashi E, Zhang Y, Schaller B, Miron R. An in vitro study of fibrin sealant as a carrier system for recombinant human bone morphogenetic protein (rhBMP)-9 for bone tissue engineering. J Craniomaxillofac Surg. 2017;45:27-32 pubmed publisher
    ..had little influence on osteoblast differentiation; however its combination with rhBMP9 significantly increased ALP activity at 7 days, Alizarin Red staining at 14 days, and mRNA levels of osteoblast differentiation markers ALP, ..
  75. Li X, Chang B, Wang B, Bu W, Zhao L, Liu J, et al. Rapamycin promotes osteogenesis under inflammatory conditions. Mol Med Rep. 2017;16:8923-8929 pubmed publisher
    ..the gene expression levels of Sp7 transcription factor, runt related transcription factor 2, alkaline phosphatase (ALP) and collagen I (Col I), ALP activity, and calcium nodule at different time points in vitro, indicating that ..
  76. Alcaide M, Rodriguez V, Brown M, Pallikkuth S, Arheart K, Martinez O, et al. High Levels of Inflammatory Cytokines in the Reproductive Tract of Women with BV and Engaging in Intravaginal Douching: A Cross-Sectional Study of Participants in the Women Interagency HIV Study. AIDS Res Hum Retroviruses. 2017;33:309-317 pubmed publisher
    ..chemotactic protein-1 (MCP1), tumor necrosis factor alpha (TNF?), and secretory leukocyte protease inhibitor [SLPI]) were measured. Fourteen (19%) women reported intravaginal douching; 24 (33%) had BV...
  77. Westin U, Fryksmark U, Polling A, Ohlsson K. Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa. Acta Otolaryngol. 1994;114:199-202 pubmed
    Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorph-nuclear granulocyte elastase and cathepsin G...
  78. Liao H, Lee M, Tsai W, Wang H, Lu W. Osteogenesis of adipose-derived stem cells on polycaprolactone-?-tricalcium phosphate scaffold fabricated via selective laser sintering and surface coating with collagen type I. J Tissue Eng Regen Med. 2016;10:E337-E353 pubmed publisher
    ..demonstrated that pASCs had the best osteogenic differentiation on PCL-TCP-COL group scaffolds, due to the highest ALP activity, osteocalcin mRNA expression and mineralization...
  79. Reinwald Y, El Haj A. Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration. J Biomed Mater Res A. 2017;: pubmed publisher
    ..Significant up-regulation of Collagen-I, ALP, and Runx-2 were observed for random and aligned fibers following mechanical stimulation; highest levels of ..
  80. Ncube S, Saidi P, Tivapasi M, Imbayarwo Chikosi V, Halimani T. Serum lipid, enzyme, and hematological responses of broilers fed Acacia angustissima leaf meal-based diets. Trop Anim Health Prod. 2018;50:665-670 pubmed publisher
    ..collected from the jugular vein in plain vacutainer tubes for alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), high-density lipoprotein cholesterol (HDL-C), low-..
  81. Xu Q, Li B, Yuan L, Dong Z, Zhang H, Wang H, et al. Combination of platelet-rich plasma within periodontal ligament stem cell sheets enhances cell differentiation and matrix production. J Tissue Eng Regen Med. 2017;11:627-636 pubmed publisher
    ..matrix proteins, the results of scanning electron microscopy and the expression of the osteogenic genes ALP, Runx2, Col-1 and OCN, the provision of 1% PRP for PDLSC sheets was the most effective PRP administration mode for ..
  82. Hida K, Maishi N, Akiyama K, Ohmura Kakutani H, Torii C, Ohga N, et al. Tumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance. Cancer Sci. 2017;108:2195-2203 pubmed publisher
    ..population increased along with upregulation of stem-related genes such as multidrug resistance 1, CD90, ALP, and Oct-4. Tumor CM also induced sphere-forming ability in HMVEC...
  83. Tang Y, Liu L, Wang P, Chen D, Wu Z, Tang C. Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions. Cell Prolif. 2017;50: pubmed publisher
    ..A scratch assay was used to analyse cell migration. Alkaline phosphatase (ALP) activity, Alizarin Red staining and expression of osteogenesis-related genes were used to investigate the ..
  84. Sha Y, Lv Y, Xu Z, Yang L, Hao X, Afandi R. MGF E peptide pretreatment improves the proliferation and osteogenic differentiation of BMSCs via MEK-ERK1/2 and PI3K-Akt pathway under severe hypoxia. Life Sci. 2017;189:52-62 pubmed publisher
    ..Osteogenic differentiation of BMSCs and osteoblast-specific genes were detected through alkaline phosphatase (ALP) and Alizarin Red S staining, and quantitative real-time PCR, respectively...
  85. Hairul Islam M, Saravanan S, Thirugnanasambantham K, Chellappandian M, Simon Durai Raj C, Karikalan K, et al. Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling. Int Immunopharmacol. 2017;53:114-124 pubmed publisher
    ..In in vitro, the compound treatment significantly increased the cell proliferation and ALP levels in osteoblast cells; the high proliferation (153.8600±5.23%) and ALP release (165.6033±4...
  86. Nystrom M, Westin U, Linder C, Ohlsson K. Secretory leukocyte protease inhibitor in punch biopsies from human colonic mucosa. Mediators Inflamm. 2001;10:269-72 pubmed
    Secretory leukocyte protease inhibitor (SLPI) is a well-known protease inhibitor. Its function is thought to be protease/protease-inhibitor balance...
  87. Xuan Q, Yang X, Mo L, Huang F, Pang Y, Qin M, et al. Expression of the serine protease kallikrein 7 and its inhibitor antileukoprotease is decreased in prostate cancer. Arch Pathol Lab Med. 2008;132:1796-801 pubmed publisher
    ..Antileukoprotease (ALP) has been shown to be a specific inhibitor of human kallikrein 7 (hK7)...
  88. Guo H, Liu Y, Wang L, Zhang G, Su S, Zhang R, et al. Alleviation of doxorubicin-induced hepatorenal toxicities with sesamin via the suppression of oxidative stress. Hum Exp Toxicol. 2016;: pubmed
    ..urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP)...
  89. Dourado D, Matias R, Barbosa Ferreira M, da Silva B, de Araujo Isaias Muller J, Vieira W, et al. Effects of photobiomodulation therapy on Bothrops moojeni snake-envenomed gastrocnemius of mice using enzymatic biomarkers. Lasers Med Sci. 2017;32:1357-1366 pubmed publisher
    ..Blood biochemistry for creatine kinase (CK), alkaline phosphatase (ALP), acid phosphatase (AP), lactate dehydrogenase (LDH), aspartate transaminase (AST), and myoglobin and ..
  90. Wang L, Lu W, Shi J, Zhang H, Xu X, Gao B, et al. Anti?osteoporotic effects of tetramethylpyrazine via promoting osteogenic differentiation and inhibiting osteoclast formation. Mol Med Rep. 2017;16:8307-8314 pubmed publisher
    ..50, 100 and 200 µM) ameliorated the negative effects of Dex by promoting the activity of alkaline phosphatase (ALP) and the calcium mineralization of BMSCs following osteogenic induction, which increased the expression levels of ..
  91. Nudi F, Biondi Zoccai G, Schillaci O, Di Belardino N, Versaci F, Nudi A, et al. Prognostic accuracy of myocardial perfusion imaging in octogenarians. J Nucl Cardiol. 2018;25:1342-1349 pubmed publisher
    Myocardial perfusion imaging (MPI) has an established role in the work-up of coronary artery disease (CAD), but its comparative accuracy is debated in elderly patients...
  92. Arami H, Teeman E, Troksa A, Bradshaw H, Saatchi K, Tomitaka A, et al. Tomographic magnetic particle imaging of cancer targeted nanoparticles. Nanoscale. 2017;9:18723-18730 pubmed publisher
    Magnetic Particle Imaging (MPI) is an emerging, whole body biomedical imaging technique, with sub-millimeter spatial resolution and high sensitivity to a biocompatible contrast agent consisting of an iron oxide nanoparticle core and a ..