SLC9B2

Summary

Gene Symbol: SLC9B2
Description: solute carrier family 9 member B2
Alias: NHA2, NHE10, NHEDC2, sodium/hydrogen exchanger 9B2, NHE domain-containing protein 2, Na(+)/H(+) exchanger NHA2, Na(+)/H(+) exchanger-like domain-containing protein 2, Na+/H+ exchanger domain containing 2, mitochondrial Na(+)/H(+) exchanger NHA2, mitochondrial sodium/hydrogen exchanger 9B2, mitochondrial sodium/hydrogen exchanger NHA2, sodium/hydrogen exchanger-like domain-containing protein 2, solute carrier family 9 subfamily B member 2, solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2, solute carrier family 9, subfamily B (cation proton antiporter 2), member 2
Species: human
Products:     SLC9B2

Top Publications

  1. Deisl C, Simonin A, Anderegg M, Albano G, Kovacs G, Ackermann D, et al. Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells. Proc Natl Acad Sci U S A. 2013;110:10004-9 pubmed publisher
    b>NHA2 is a sodium/hydrogen exchanger with unknown physiological function. Here we show that NHA2 is present in rodent and human β-cells, as well as β-cell lines...
  2. Choy J, Albers C, Siebenrock K, Dolder S, Hofstetter W, Klenke F. Incorporation of RANKL promotes osteoclast formation and osteoclast activity on β-TCP ceramics. Bone. 2014;69:80-8 pubmed publisher
    ..encoding the osteoclast gene products cathepsin K, calcitonin receptor, and of the sodium/hydrogen exchanger NHA2 were quantified by real-time PCR...
  3. Dundar A, Sengun A, Başlak C, Kus M. Effects of citric acid modified with fluoride, nano-hydroxyapatite and casein on eroded enamel. Arch Oral Biol. 2018;93:177-186 pubmed publisher
    ..047 mmol/L sodium fluoride, F2: 0.071 mmol/L sodium fluoride, NHA1: %0.05 Nano-Hydroxyapatite, NHA2: %0.1 Nano-Hydroxyapatite, C1: %0.02 Casein, C2: %0.2 Casein...
  4. Chintapalli V, Kato A, Henderson L, Hirata T, Woods D, Overend G, et al. Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proc Natl Acad Sci U S A. 2015;112:11720-5 pubmed publisher
    ..In Drosophila, as in humans, they are represented by two genes, Nha1 (Slc9b1) and Nha2 (Slc9b2), which are enriched and functionally significant in renal tubules...
  5. Chen S, Chen M, Deng S, Hao X, Wang X, Liu Y. Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Cell Death Dis. 2016;7:e2152 pubmed publisher
    ..Similar to Nha1 cKO males, Nha2(Fx/Fx), Zp3-Cre (hereafter called Nha2 cKO) male mice were subfertile, indicating these two Nha genes may be ..
  6. Deisl C, Anderegg M, Albano G, Lüscher B, Cerny D, Soria R, et al. Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice. PLoS ONE. 2016;11:e0163568 pubmed publisher
    We previously demonstrated that the sodium/hydrogen exchanger NHA2, also known as NHEDC2 or SLC9B2, is critical for insulin secretion by ?-cells...
  7. Padan E, Landau M. Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease. Met Ions Life Sci. 2016;16:391-458 pubmed publisher
    ..Nevertheless, the Ec-NhaA crystal structure has enabled the structural modeling of NHE1, NHE9, and NHA2, three human plasmalemmal proteins that are members of the SLC9 family that are involved in human pathophysiology...
  8. Kondapalli K, Todd Alexander R, Pluznick J, Rao R. NHA2 is expressed in distal nephron and regulated by dietary sodium. J Physiol Biochem. 2017;73:199-205 pubmed publisher
    ..b>NHA2 is a newly identified Na+(Li+)/H+ antiporter with potential genetic links to ..
  9. Fuster D, Zhang J, Shi M, Bobulescu I, Andersson S, Moe O. Characterization of the sodium/hydrogen exchanger NHA2. J Am Soc Nephrol. 2008;19:1547-56 pubmed publisher
    ..In this study, a cDNA from a human brain library, previously designated NHA2 in the genome, was cloned and characterized...

More Information

Publications17

  1. Uzdavinys P, Coinçon M, Nji E, Ndi M, Winkelmann I, von Ballmoos C, et al. Dissecting the proton transport pathway in electrogenic Na+/H+ antiporters. Proc Natl Acad Sci U S A. 2017;114:E1101-E1110 pubmed publisher
    ..We further show that the exchange activity of the human Na+/H+ exchanger NHA2 (SLC9B2) is electroneutral, despite harboring the two conserved aspartic acid residues found in NapA and other ..
  2. Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, Ben Tal N. Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. J Mol Biol. 2010;396:1181-96 pubmed publisher
    Human NHA2 is a poorly characterized Na(+)/H(+) antiporter recently implicated in essential hypertension...
  3. Landreh M, Marklund E, Uzdavinys P, Degiacomi M, Coincon M, Gault J, et al. Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters. Nat Commun. 2017;8:13993 pubmed publisher
    ..thermophilus and compare this to the prototypical antiporter NhaA from Escherichia coli and the human homologue NHA2. We find that NapA and NHA2, but not NhaA, form stable dimers and do not selectively retain membrane lipids...
  4. Xiang M, Feng M, Muend S, Rao R. A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. Proc Natl Acad Sci U S A. 2007;104:18677-81 pubmed
    ..unknown clade of genes in metazoan genomes, including two previously uncharacterized human isoforms, NHA1 and NHA2, found in tandem on human chromosome 4...
  5. Ha B, Hong J, Park J, Ha M, Kim T, Cho J, et al. Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion. Proteomics. 2008;8:2625-39 pubmed publisher
    ..We found several ion channel proteins such as Ank and Nhedc2 and signaling molecules such as Dock5 and RAB-10 in osteoclasts...
  6. Huang X, Morse L, Xu Y, Zahradka J, Sychrova H, Stashenko P, et al. Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae. Biochim Biophys Acta. 2010;1800:1241-7 pubmed publisher
    NHAoc/NHA2 is highly and selectively expressed in osteoclasts and plays a role(s) in normal osteoclast differentiation, apoptosis and bone resorptive function in vitro...
  7. Kondapalli K, Kallay L, Muszelik M, Rao R. Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient. J Biol Chem. 2012;287:36239-50 pubmed publisher
    Human NHA2, a newly discovered cation proton antiporter, is implicated in essential hypertension by gene linkage analysis...
  8. Battaglino R, Pham L, Morse L, Vokes M, Sharma A, Odgren P, et al. NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. Bone. 2008;42:180-92 pubmed
    ..Gene function studies were carried out by siRNA analysis. We identified a novel gene, which we termed nha-oc/NHA2, which is strongly upregulated during RANKL-induced osteoclast differentiation in vitro and in vivo...