SLC9A3R1

Summary

Gene Symbol: SLC9A3R1
Description: solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Alias: EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2, Na(+)/H(+) exchange regulatory cofactor NHE-RF1, Na+/H+ exchange regulatory co-factor, ezrin-radixin-moesin binding phosphoprotein-50, ezrin-radixin-moesin-binding phosphoprotein 50, regulatory cofactor of Na(+)/H(+) exchanger, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1, solute carrier family 9 isoform A3 regulatory factor 1
Species: human

Top Publications

  1. pmc Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
    D Reczek
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 139:169-79. 1997
  2. ncbi The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    R A Hall
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 392:626-30. 1998
  3. pmc Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity
    S Maudsley
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 20:8352-63. 2000
  4. pmc Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger
    E J Weinman
    Department of Medicine, University of California, Los Angeles School of Medicine, USA
    J Clin Invest 95:2143-9. 1995
  5. pmc A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins
    R A Hall
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:8496-501. 1998
  6. ncbi Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 417:858-61. 2002
  7. pmc Ezrin-radixin-moesin-binding phosphoprotein (EBP50), an estrogen-inducible scaffold protein, contributes to biliary epithelial cell proliferation
    Laura Fouassier
    INSERM, UMR_S 893, CdR Saint Antoine, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Am J Pathol 174:869-80. 2009
  8. pmc Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation
    Jennifer R Molina
    Department of Neuro Oncology and Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Res 70:6697-703. 2010
  9. ncbi EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Hepatology 38:178-86. 2003
  10. pmc NHERF1/EBP50 is a new marker in colorectal cancer
    Yuho Hayashi
    Department of Neuro Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 12:1013-22. 2010

Research Grants

  1. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2010
  2. PTH1R SIGNALING BY CYTOPLASMIC BINDING PARTNERS
    WILLIAM SNEDDON; Fiscal Year: 2005
  3. NHERFs Specify PTH Receptor Signaling
    Harald Juppner; Fiscal Year: 2005
  4. NHERF-1 and PTH regulation of the renal transport of phosphate.
    Edward J Weinman; Fiscal Year: 2010
  5. A role for EPI64 in microvilli organization
    DAVID LALONDE; Fiscal Year: 2007
  6. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2006
  7. Na+-H+ Transport in Renal Apical Membranes
    Edward Weinman; Fiscal Year: 2006
  8. PTH RECEPTOR: FUNCTION MEETS FORM
    Peter A Friedman; Fiscal Year: 2010
  9. REGULATION OF CFTR TRAFFICKING
    BRUCE STANTON; Fiscal Year: 2002
  10. Cellular Pharmacology of Kappa Opioid Receptor
    Lee Yuan Liu Chen; Fiscal Year: 2007

Detail Information

Publications167 found, 100 shown here

  1. pmc Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
    D Reczek
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 139:169-79. 1997
    ..We refer to these polypeptides as ERM-binding phosphoprotein 50 (EBP50)...
  2. ncbi The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    R A Hall
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 392:626-30. 1998
    ..direct agonist-promoted association of the beta2-adrenergic receptor with the Na+/H+ exchanger regulatory factor (NHERF), a protein that regulates the activity of the Na+/H+ exchanger type 3 (NHE3)...
  3. pmc Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity
    S Maudsley
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 20:8352-63. 2000
    ..We show here that the Na(+)/H(+) exchanger regulatory factor (NHERF; also known as EBP50), a protein not previously known to interact with the PDGFR, binds to the PDGFR carboxyl terminus (PDGFR-CT) with ..
  4. pmc Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger
    E J Weinman
    Department of Medicine, University of California, Los Angeles School of Medicine, USA
    J Clin Invest 95:2143-9. 1995
    ..Reverse transcription/PCR studies in the kidney indicate the presence of mRNA for NHE-RF in several distinct nephron segments including the proximal tubule...
  5. pmc A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins
    R A Hall
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:8496-501. 1998
    The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange...
  6. ncbi Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 417:858-61. 2002
    ..Here we show that the PTH1R binds to Na(+)/H(+) exchanger regulatory factors (NHERF) 1 and 2 through a PDZ-domain interaction in vitro and in PTH target cells...
  7. pmc Ezrin-radixin-moesin-binding phosphoprotein (EBP50), an estrogen-inducible scaffold protein, contributes to biliary epithelial cell proliferation
    Laura Fouassier
    INSERM, UMR_S 893, CdR Saint Antoine, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Am J Pathol 174:869-80. 2009
    Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) anchors and regulates apical membrane proteins in epithelia. EBP50 is inducible by estrogen and may affect cell proliferation, although this latter function remains unclear...
  8. pmc Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation
    Jennifer R Molina
    Department of Neuro Oncology and Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Res 70:6697-703. 2010
    ..The PTEN binding adapter protein NHERF1/EBP50 is overexpressed in GBM but its effects on tumorigenesis have yet to be determined...
  9. ncbi EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Hepatology 38:178-86. 2003
    ..By protein interaction screening, we identified EBP50, a cytoplasmic protein with 2 PDZ domains, as a beta-catenin-associating molecule...
  10. pmc NHERF1/EBP50 is a new marker in colorectal cancer
    Yuho Hayashi
    Department of Neuro Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 12:1013-22. 2010
    ..We report here that Na(+)/H(+) exchanger 3 regulating factor 1 (NHERF1)/EBP50, an adaptor molecule that interacts with β-catenin, undergoes successive alterations during the colorectal ..
  11. ncbi Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets
    James W Voltz
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:33879-87. 2007
    NHERF-1 (Na(+)-H(+) exchanger regulatory factor 1, also known as EBP50 ezrin-binding protein of 50 kDa) is a phosphoprotein that assembles multiprotein complexes via two PDZ domains and a C-terminal ezrin-binding domain...
  12. pmc A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization
    David P LaLonde
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 21:1519-29. 2010
    PDZK1 and ezrin, radixin, moesin binding phosphoprotein 50 kDa (EBP50) are postsynaptic density 95/disc-large/zona occludens (PDZ)-domain-containing scaffolding proteins found in the apical microvilli of polarized epithelial cells...
  13. pmc Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer
    Maha M Hammad
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 285:34653-64. 2010
    ..We identified a receptor adaptor interacting specifically with one receptor complex but not others. NHERF1, an adaptor known for its role in desensitization, internalization, and regulation of the ERK signaling cascade ..
  14. doi Biological role of NHERF1 protein expression in breast cancer
    Anita Mangia
    Clinical Experimental Oncology Laboratory, National Cancer Institute, Bari, Italy
    Histopathology 55:600-8. 2009
    To determine the role of Na+/H+ exchanger regulatory factor (NHERF1) in breast cancerogenesis and progression.
  15. doi Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells
    A Claperon
    INSERM, UMRS_938, Paris, France
    Oncogene 31:1376-88. 2012
    ..The scaffold protein ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is highly expressed at the plasma membrane of normal biliary epithelial cells and binds epidermal growth factor ..
  16. ncbi kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins
    Peng Huang
    Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 279:25002-9. 2004
    ..showed that Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) co-immunoprecipitated with the human kappa opioid receptor (hKOR) and that its overexpression blocked the kappa ..
  17. ncbi The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells
    S Breton
    Renal Unit and Program in Membrane Biology and the Molecular Neurogenetics Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 275:18219-24. 2000
    ..The colocalization of NHE-RF and H(+)ATPase in B- but not A-intercalated cells suggests a role in generating, maintaining, or modulating the variable H(+)ATPase polarity that characterizes the B-cell phenotype...
  18. doi EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity
    Jun Fang Zheng
    Department of Biochemistry and Molecular Biology, Capital Medical University, No 10 Xitoutiao, You An Men, 100069, Beijing, People s Republic of China
    Amino Acids 38:1261-8. 2010
    The expression of Ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) and the intragenic mutation of the ebp50 gene have been reported to correlate with human breast cancer development, but the exact impacts on breast cancer ..
  19. ncbi The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain
    Casey M Finnerty
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 117:1547-52. 2004
    ..crosslinking proteins that, upon activation, bind the scaffolding protein ERM-phosphoprotein of 50 kDa (EBP50). Here we report a 3...
  20. ncbi Structural basis for NHERF recognition by ERM proteins
    Shin ichi Terawaki
    Structural Biology Laboratory, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Structure 14:777-89. 2006
    The Na+/H+ exchanger regulatory factor (NHERF) is a key adaptor protein involved in the anchoring of ion channels and receptors to the actin cytoskeleton through binding to ERM (ezrin/radixin/moesin) proteins...
  21. pmc Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:25134-8. 2010
    The phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by parathyroid hormone (PTH) and dopamine...
  22. pmc NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity
    Rafiquel Sarker
    Gastroenterology and Hepatology Division, Department of Medicine, Johns Hopkins Univ School of Medicine, Baltimore, MD 21205 2195, USA
    Am J Physiol Cell Physiol 300:C771-82. 2011
    ..Most studies of NHE3 regulation have been in cell models in which NHERF1 and/or NHERF2 were overexpressed...
  23. ncbi Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
    S M Gisler
    Institute of Physiology, Veterinary Biochemistry, and Anatomy, University of Zurich Irchel, CH 8057 Zurich, Switzerland
    J Biol Chem 276:9206-13. 2001
    ..found belonged to proteins with multiple PDZ modules and were either identical/related to PDZK1 or identical to NHERF-1...
  24. pmc Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
    Juan A Ardura
    Laboratory for G Protein coupled Receptor Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 286:35020-9. 2011
    Na/H exchanger regulatory factor-1 (NHERF1) is a cytoplasmic PDZ (postsynaptic density 95/disc large/zona occludens) protein that assembles macromolecular complexes and determines the localization, trafficking, and signaling of select G ..
  25. pmc Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling
    D S Wheeler
    Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 30:32-42. 2011
    ..We show here that the adaptor protein Na(+)/H(+) exchange regulatory factor1 (NHERF1), a protein abundantly expressed in normal mammary epithelium, regulates Wnt signaling, maintaining low levels of ..
  26. ncbi A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor
    T T Cao
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    Nature 401:286-90. 1999
    ..The phosphoprotein EBP50 (for ezrinradixin-moesin(ERM)-binding phosphoprotein-50) binds to the cytoplasmic tail of the beta2-adrenergic ..
  27. pmc PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
    Yoko Takahashi
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 25:910-20. 2006
    ..We show here that PTEN interacts directly with the NHERF1 and NHERF2 (Na+/H+ exchanger regulatory factor) homologous adaptor proteins through the PDZ motif of PTEN and the ..
  28. ncbi Expression and clinicopathological significance of oestrogen-responsive ezrin-radixin-moesin-binding phosphoprotein 50 in breast cancer
    J Song
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Histopathology 51:40-53. 2007
    Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is a post synaptic density-95/Disk-large/ZO-1 homologous domain-containing protein that is involved in the linkage of integral membrane proteins to the cytoskeleton and plays an ..
  29. pmc NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding
    Bin Wang
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Pharmacol 75:1189-97. 2009
    ..The Na(+)/H(+) exchange regulatory factor 1 (NHERF1) is a cytoplasmic adapter protein that regulates trafficking and signaling of several G protein-coupled receptors (..
  30. ncbi Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes
    Whaseon Lee-Kwon
    Johns Hopkins Univ School of Medicine, 925 Ross Research Bldg, 720 Rutland Ave, Baltimore, MD 21205 2195, USA
    Am J Physiol Cell Physiol 285:C1527-36. 2003
    ..These results suggest that PKCalpha is not necessary for the Ca2+-dependent formation of the NHE3 plasma membrane complex, although it is necessary for decreasing the membrane amounts of NHE3, probably by stimulating NHE3 endocytosis...
  31. doi NHERF1 mutations and responsiveness of renal parathyroid hormone
    Zoubida Karim
    INSERM Unité 845, Universite Paris Descartes, Faculte de Medecine, Paris, France
    N Engl J Med 359:1128-35. 2008
    ..Data from animal models suggest that sodium-hydrogen exchanger regulatory factor 1 (NHERF1) controls renal phosphate transport...
  32. pmc Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits
    Bin Wang
    Laboratory for G Protein coupled Receptor Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:26976-86. 2010
    The Na/H exchanger regulatory factors, NHERF1 and NHERF2, are adapter proteins involved in targeting and assembly of protein complexes. The parathyroid hormone receptor (PTHR) interacts with both NHERF1 and NHERF2...
  33. ncbi Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF
    Y Tang
    Neurobiotechnology Center and Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 275:37559-64. 2000
    ..show that murine Trp4 and Trp5, as well as phospholipase C beta1 and beta2 interact with the first PDZ domain of NHERF, regulatory factor of the Na(+)/H(+) exchanger...
  34. ncbi Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains
    S Karthikeyan
    Molecular Medicine Laboratory and Macromolecular Crystallography Unit, Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Mol Biol 308:963-73. 2001
    The Na(+)/H(+) exchanger regulatory factor (NHERF; also known as EBP50) contains two PDZ domains that mediate the assembly of transmembrane and cytosolic proteins into functional signal transduction complexes...
  35. pmc Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)
    Yong Pan
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Breast Cancer Res 8:R63. 2006
    Na+/H+ exchanger regulatory factor 1 (NHERF1, also known as EBP50 or NHERF) is a putative tumour suppressor gene in human breast cancer. Located at 17q25.1, NHERF1 is frequently targeted during breast tumourigenesis...
  36. pmc Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50
    P J Mohler
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 147:879-90. 1999
    ..of the cystic fibrosis transmembrane conductance regulator associates with the submembranous scaffolding protein EBP50 (ERM-binding phosphoprotein 50 kD; also called Na(+)/H(+) exchanger regulatory factor)...
  37. pmc Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2XY, UK
    BMC Med Genet 7:20. 2006
    ..Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with other immune-mediated diseases might perturb immune homeostasis, and hence also associate with predisposition to T1D...
  38. ncbi G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction
    R A Hall
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:24328-34. 1999
    The Na(+)/H(+) exchanger regulatory factor (NHERF) is constitutively phosphorylated in cells, but the site(s) of this phosphorylation and the kinase(s) responsible for it have not been identified...
  39. ncbi NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancer
    Jia Le Dai
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:8681-7. 2004
    ..The screening yielded NHERF (Na+/H+ exchanger regulatory factor, also known as NHERF1 or EBP-50) that binds to the interdomain B of SYK...
  40. ncbi A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration
    Marianne F James
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Cell Sci 117:2951-61. 2004
    The Na(+)/H(+) exchanger regulatory factor, NHERF, is a multifunctional adapter protein involved in a wide range of physiological activities...
  41. ncbi Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)
    S Wang
    Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS Lett 427:103-8. 1998
    ..The specific and tight association suggests a potential regulatory role of NHE-RF in cystic fibrosis transmembrane conductance regulator (CFTR) function...
  42. pmc NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
    Fabiana C Morales
    Department of Neuro Oncology, M D Anderson Cancer Center, The University of Texas, 6767 Bertner Avenue, Houston, TX 77030, USA
    Mol Cell Biol 27:2527-37. 2007
    ..We describe here an intramolecular conformation of NHERF1/EBP50 (ERM-binding phosphoprotein 50) in which the C-terminal EB region binds to the PDZ2 domain...
  43. ncbi A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis
    Cynthia Helms
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 35:349-56. 2003
    ..Associated single-nucleotide polymorphisms (SNPs) in the proximal peak lie in or near SLC9A3R1 (also called EBP50 and NHERF1) and NAT9, a new member of the N-acetyltransferase family...
  44. ncbi An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton
    D B Short
    Department of Physiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 273:19797-801. 1998
    ..Here we report that CFTR interacts with the recently discovered protein, EBP50 (ERM-binding phosphoprotein 50)...
  45. pmc Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1
    Jianquan Li
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Mol Biol 392:166-80. 2009
    ..The scaffolding protein Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) assembles macromolecular signaling complexes and regulates the macromolecular assembly, localization, and ..
  46. ncbi Estrogen receptor inducibility of the human Na+/H+ exchanger regulatory factor/ezrin-radixin-moesin binding protein 50 (NHE-RF/EBP50) gene involving multiple half-estrogen response elements
    Tracy R Ediger
    Department of Cell and Structural Biology, University of Illinois and College of Medicine, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 16:1828-39. 2002
    ..Our findings highlight a paradigm for gene regulation via numerous half-ERE sites that expands the range of modes by which DNA recognition sites mediate the actions of this nuclear receptor...
  47. pmc NHERF-1: modulator of glioblastoma cell migration and invasion
    Kerri L Kislin
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Neoplasia 11:377-87. 2009
    ..Na(+)/H(+) exchanger regulatory factor 1 (NHERF-1) is a multifunctional adaptor protein, recruiting cytoplasmic signaling proteins and membrane receptors/..
  48. pmc Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
    D Reczek
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 153:191-206. 2001
    The cortical scaffolding proteins EBP50 (ERM-binding phosphoprotein-50) and E3KARP (NHE3 kinase A regulatory protein) contain two PDZ (PSD-95/DlgA/ZO-1-like) domains followed by a COOH-terminal sequence that binds to active ERM family ..
  49. ncbi Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase
    J He
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41559-65. 2001
    Na(+)/H(+) exchanger regulatory factor (NHERF)-1 is a PDZ domain-containing adaptor protein known to bind to various receptors, channels, cytoskeletal elements, and cytoplasmic signaling proteins...
  50. pmc Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction
    V Raghuram
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6100, USA
    Proc Natl Acad Sci U S A 98:1300-5. 2001
    ..The Na(+)/H(+) exchanger regulatory factor (NHERF) binds to the cytoplasmic tail of CFTR through either of its two PDZ (PDZ1 and PDZ2) domains...
  51. ncbi Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly
    Jianquan Li
    Basic Science Division and Population Science Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 282:27086-99. 2007
    ..kinase C (PKC) phosphorylation influences the scaffolding protein Na(+)/H(+) exchanger regulatory factor 1 (NHERF) to assemble protein complexes of cystic fibrosis transmembrane conductance regulator (CFTR), a chloride ion ..
  52. pmc A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions
    Viswanathan Raghuram
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Proc Natl Acad Sci U S A 100:9620-5. 2003
    ..The Na+/H+ exchanger regulatory factor (NHERF) binds to CFTR and increases its open probability (Po)...
  53. ncbi NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling
    Bin Wang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 282:36214-22. 2007
    Na/H exchange regulatory factor-1 (NHERF1) is a PDZ protein that regulates trafficking of several G protein-coupled receptors...
  54. ncbi NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins
    A Murthy
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Biol Chem 273:1273-6. 1998
    ....
  55. pmc cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein
    C H Yun
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:3010-5. 1997
    ..We have identified two regulatory proteins, E3KARP and NHERF, that interact with NHE3 to enable cAMP to inhibit NHE3...
  56. pmc The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells
    Rosa A Cardone
    Department of General and Environmental Physiology, University of Bari, 70126 Bari, Italy
    Mol Biol Cell 18:1768-80. 2007
    ..Na(+)/H(+) exchanger regulatory factor (NHERF1) is a postsynaptic density 95/disc-large/zona occludens (PDZ) domain-containing protein that recruits membrane ..
  57. ncbi Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology
    B S Katzenellenbogen
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, 524 Burrill Hall, 407 S Goodwin Avenue, 61801 3704, Urbana, IL, USA
    J Steroid Biochem Mol Biol 74:279-85. 2000
    ..cell cytoarchitectural changes including NHE-RF, the sodium hydrogen exchanger regulatory factor, also known as EBP50. NHE-RF/EBP50 is enriched in microvilli, and may serve as a scaffold adaptor protein in regulating early changes ..
  58. ncbi Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells
    Syed Jalal Khundmiri
    Department of Medicine, University of Louisville, Kidney Disease Program, Louisville, KY 40202, USA
    J Am Soc Nephrol 16:2598-607. 2005
    It was demonstrated that expression of murine sodium hydrogen exchanger regulatory factor (NHERF-1) lacking the ezrin-binding domain blocks parathyroid hormone (PTH) regulation of Na+,K+-ATPase in opossum kidney (OK) cells...
  59. doi Role of NHERF and scaffolding proteins in proximal tubule transport
    Rochelle Cunningham
    Division of Nephrology, Department of Medicine, University of Maryland, School of Medicine, Room N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Urol Res 38:257-62. 2010
    ..The NHERF (sodium hydrogen exchanger regulatory factor) proteins are PDZ domain-containing proteins that play an important ..
  60. doi Ezrin promotes functional expression and parathyroid hormone-mediated regulation of the sodium-phosphate cotransporter 2a in LLC-PK1 cells
    Matthew J Mahon
    Department of Medicine, Harvard Medical School and Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 294:F667-75. 2008
    ..membrane expression of NPT2a is dependent on interactions with the sodium-hydrogen exchanger regulatory factor 1 (NHERF-1)...
  61. pmc PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP
    Edward J Weinman
    Dept of Medicine, Div of Nephrology, Univ of Maryland School of Medicine, Baltimore, MD 21202, USA
    Am J Physiol Renal Physiol 297:F1560-5. 2009
    ..2a (Npt2a) binds to a number of PDZ adaptor proteins including sodium-hydrogen exchanger regulatory factor-1 (NHERF-1), which regulates its retention in the apical membrane of renal proximal tubule cells and the response to ..
  62. ncbi Molecular effects of volume expansion on the renal sodium phosphate cotransporter
    Jules B Puschett
    Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Am J Med Sci 326:1-8. 2003
    ..In recent experiments, Sprague-Dawley rats were subjected to the same short term VE. For both control and VE animals, brush border membrane vesicles (BBMV) were obtained...
  63. doi Synthesis and screening of support-bound combinatorial peptide libraries with free C-termini: determination of the sequence specificity of PDZ domains
    Sang Hoon Joo
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    Biochemistry 47:3061-72. 2008
    ..density-95/discs large/zona occluden-1 (PDZ) domains of sodium-hydrogen exchanger regulatory factor-1 (NHERF1) and channel-interacting PDZ domain protein (CIPP)...
  64. ncbi Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    J Am Soc Nephrol 18:1419-25. 2007
    Sodium-hydrogen exchanger regulatory factor-1-deficient (NHERF-1(-/-)) mice demonstrate increases in the urinary excretion of phosphate, calcium, and uric acid associated with interstitial deposition of calcium in the papilla of the ..
  65. ncbi Expression of NHERF-1, NHERF-2, PDGFR-alpha, and PDGFR-beta in normal human kidneys and in renal transplant rejection
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Pathobiology 70:314-23. 2002
    Sodium-hydrogen exchanger regulatory factor-1 and -2 (NHERF-1 and NHERF-2) are adaptor proteins that regulate renal electrolyte transport and interact with the platelet-derived growth factor receptors (PDGFR)...
  66. doi Novel regulatory function for NHERF-1 in Npt2a transcription
    Syed Jalal Khundmiri
    Department of Medicine, Univ of Louisville, Kidney Disease Program, 570 S Preston St, Suite 102, Louisville, KY 40202, USA
    Am J Physiol Renal Physiol 294:F840-9. 2008
    Several lines of evidence show that sodium/hydrogen exchanger regulatory factor 1 (NHERF-1) regulates the expression and activity of the type IIa sodium-dependent phosphate transporter (Npt2a) in renal proximal tubules...
  67. pmc The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Their 10, Boston, Massachusetts 02114, USA
    Mol Endocrinol 23:1691-701. 2009
    ..a psd-95, discs large, ZO-1 domain interaction motif that binds the sodium-hydrogen exchanger regulatory factor 1 (NHERF-1), a renal tubule scaffold protein...
  68. pmc Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 117:3412-20. 2007
    ..77 (S77) of the first PDZ domain of the Npt2a-binding protein sodium-hydrogen exchanger regulatory factor-1 (NHERF-1). Using recombinant polypeptides representing PDZ I, S77 of NHERF-1 is phosphorylated by PKC but not PKA...
  69. pmc Localizations of visual cycle components in retinal pigment epithelium
    Jing Huang
    Department of Ophthalmology, University of Washington, School of Medicine, Seattle, WA, USA
    Mol Vis 15:223-34. 2009
    ..The localizations of these enzymes were compared to known localizations of retinoid-binding proteins and associated proteins...
  70. pmc Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses
    Wellington K Ayensu
    Cellomics and Toxicogenomics Research Laboratory, NIH RCMI Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, Jackson, Mississippi 39217, USA Email
    Int J Environ Res Public Health 3:141-73. 2006
    ..family protein, CDC-like kinase 1 (CLK1 HGNC) (protein tyrosine kinase STY), Na+/H+ exchanger regulatory factor (NHERF HGNC), potassium voltage-gated channel subfamily H member 2 (KCNH2), putative MAPK activating protein (PM20, PM21),..
  71. ncbi NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes
    Edward J Weinman
    Department of Medicine, Division Nephrology, University of Maryland School of Medicine, Room N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    FEBS Lett 536:141-4. 2003
    Sodium-hydrogen exchanger regulatory factor isoform-1 (NHERF-1) and NHERF-2 are two structurally related PDZ-domain-containing protein adapters that effectively transduce cyclic AMP (cAMP) signals that inhibit NHE3, the sodium-hydrogen ..
  72. ncbi Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells
    Eleanor DeLand Lederer
    Louisville Veterans Administration Medical Center, Louisville, Kentucky, USA
    J Am Soc Nephrol 14:1711-9. 2003
    ..exchanger 3 by protein kinase A requires a protein co-factor from the sodium-hydrogen exchanger regulatory factor (NHERF) family of proteins (NHERF-1 and NHERF-2)...
  73. pmc Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:13454-60. 2010
    ..renal brush border membrane vesicles and in cultured renal proximal tubule cells from wild-type but not from NHERF-1 null mice. Co-immunoprecipitation experiments established that NHERF-1 associated with D1-like receptors...
  74. doi Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice
    Rochelle Cunningham
    Univ of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 294:F1001-7. 2008
    The adaptor proteins sodium/hydrogen exchanger regulatory factor (NHERF)-1 and NHERF-2 have overlapping tissue distribution in renal cells and overlapping specificity in their binding to renal transporters and other proteins...
  75. ncbi Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA
    E J Weinman
    Departments of Medicine and Physiology, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 279:F393-9. 2000
    ..the essential requirement for a new class of regulatory factors, sodium/hydrogen exchanger regulatory factor (NHERF) and NHERF-like proteins, in cAMP-mediated inhibition of NHE3 activity...
  76. ncbi Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France
    Curr Opin Nephrol Hypertens 13:675-81. 2004
    ..We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization...
  77. pmc The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland, School of Medicine, 22, South Greene Street, Baltimore, MD 21202, USA
    J Physiol 567:27-32. 2005
    ..In the renal proximal tubule, three PDZ adaptor proteins, namely NHERF-1, NHERF-2 and PDZK1, are expressed in the apical membrane, heterodimerize with one another, and, at least in ..
  78. pmc The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity
    Kim Hodges
    Section of Digestive Disease and Nutrition, Department of Medicine, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, IL 60612, USA
    Cell Microbiol 10:1735-45. 2008
    ..The effect on NHE3 was enhanced when PS120 cells were co-transfected with the scaffolding/regulatory proteins NHERF1 or NHERF2 or EBP50 and E3KARP respectively...
  79. ncbi The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 68:491-505. 2006
    The sodium-hydrogen exchanger regulatory factors (NHERF-1 and NHERF-2) are a family of adaptor proteins characterized by the presence of two tandem PDZ protein interaction domains and a C-terminal domain that binds the cytoskeleton ..
  80. doi Parathyroid hormone signaling in bone and kidney
    Minnkyong Lee
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Curr Opin Nephrol Hypertens 18:298-302. 2009
    ..Here, we will review the recent advancements regarding PTH signaling in bone and kidney...
  81. ncbi NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors
    David Wheeler
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 282:25076-87. 2007
    The sodium-hydrogen exchange regulatory factor 1 (NHERF-1/EBP50) interacts with the C terminus of several G protein-coupled receptors (GPCRs)...
  82. ncbi NHE3 and NHERF are targeted to the basolateral membrane in proximal tubules of colchicine-treated rats
    Ivan Sabolic
    Unit of Molecular Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Kidney Int 61:1351-64. 2002
    ..acutely regulated by a variety of mechanisms, including protein trafficking and interaction with the PDZ protein, NHERF. The effects of microtubule disruption by colchicine on NHE3 trafficking in PT and the potential role of NHERF in ..
  83. pmc Enrichment of distinct microfilament-associated and GTP-binding-proteins in membrane/microvilli fractions from lymphoid cells
    Jian Jiang Hao
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 7:2911-27. 2008
    ..The most enriched cytoskeletal proteins were microfilament-related proteins NHERF1, Ezrin/Radixin/Moesin (ERMs), ADF/cofilin and Myosin1G...
  84. pmc Postnatal developmental expression of the PDZ scaffolds Na+ -H+ exchanger regulatory factors 1 and 2 in the rat cochlea
    Refik Kanjhan
    School of Biomedical Sciences, The University of Queensland, St Lucia, 4072, Queensland, Australia
    Cell Tissue Res 323:53-70. 2006
    ..transporters, some of which can interact with the PDZ scaffolds, Na(+)-H(+) exchanger regulatory factors 1 and 2 (NHERF-1, NHERF-2)...
  85. ncbi Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)
    Catriona M H Anderson
    Faculty of Medical Sciences, Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 204:604-13. 2005
    ..Immunocytochemistry localises NHERF1 (NHE3 regulatory factor 1) to the apical portion of Caco-2 cells where it will interact with NHE3 and allow PKA-..
  86. doi delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation
    Anika Heiss
    Institute of Pharmacology, Toxicology and Pharmacy Ludwig Maximilians University of Munich Koeniginstrasse 16, 80539 Muenchen, Federal Republic of Germany
    Exp Cell Res 315:2115-25. 2009
    ..G(i/o) proteins, because pre-treatment with pertussis toxin, but not over-expression of the G(q/11) scavengers EBP50 and GRK2-K220R, prevented this effect...
  87. ncbi Recent findings on genes associated with inflammatory disease
    Ryo Yamada
    Laboratory for Rheumatic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 1 7 22 Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Mutat Res 573:136-51. 2005
    ..cytotoxic T lymphocyte-associated 4 (CTLA4), CARD15, DLG5, SLC22A4/A5, programmed cell death 1 (PDCD1), RUNX1, SLC9A3R1/NAT9, PADI4, ADAM33, DPP10, PHF11 and GPRA), followed by a discussion of the genes that have been implicated in ..
  88. ncbi The merlin interacting proteins reveal multiple targets for NF2 therapy
    Daniel R Scoles
    Women s Cancer Research Institute, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Biochim Biophys Acta 1785:32-54. 2008
    ..ezrin, radixin, moesin, CD44, layilin, paxillin, actin, N-WASP, betaII-spectrin, microtubules, TRBP, eIF3c, PIKE, NHERF, MAP, RalGDS, RhoGDI, EG1/magicin, HEI10, HRS, syntenin, caspr/paranodin, DCC, NGB, CRM1/exportin, SCHIP1, MYPT-1-..
  89. ncbi Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation
    Juergen Theodor Fraenzer
    House Ear Institute, Cell and Molecular Biology, Los Angeles, CA 90057, USA
    Int J Oncol 23:1493-500. 2003
    ..gene product, Merlin/Schwannomin, has recently been found to interact with the two PDZ domains containing protein EBP50/NHE-RF, which is itself known to interact with the PDGF receptor (PDGFR) in several cell types...
  90. pmc EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells
    Gyun Jee Song
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Mol Cell Cardiol 49:1012-21. 2010
    ..In this study we examined the role of the adaptor protein ezrin-radixin-moesin-binding phosphoprotein (EBP50) on PTH1R expression, trafficking, signaling and control of A10 cell proliferation...
  91. doi Regulation of the intestinal anion exchanger DRA (downregulated in adenoma)
    Georg Lamprecht
    Medical Department, University of Tubingen, Tubingen, Germany
    Ann N Y Acad Sci 1165:261-6. 2009
    ..All three transport proteins possess PDZ domain binding motifs that facilitate binding to members of the NHERF (Na/H exchanger regulatory factor) family of adapter proteins [NHERF, E3KARP (NHE3 kinase A regulatory protein), ..
  92. ncbi Agonist-induced regulation and trafficking of kappa opioid receptors
    Lee Yuan Liu-Chen
    Department of Pharmacology and Center for Substance Abuse Research, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    Life Sci 75:511-36. 2004
    ..kinase and to adenylyl cyclase superactivation, the role of the PDZ domain-containing protein NHERF-1/EBP50 in the trafficking of the hKOR and the relationship between receptor phosphorylation and tolerance development in ..
  93. pmc Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors
    Tania M Schroeder
    The Cancer Center, and Department of Orthopaedic Surgery, University of Minnesota, MMC 806, 420 Delaware Street SW, Minneapolis, MN, USA
    BMC Genomics 8:362. 2007
    ..g. alkaline phosphatase, osteocalcin). Identifying other genes that are differentially regulated by HDIs might identify new pathways that contribute to osteoblast differentiation...
  94. ncbi Na+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions
    Mohammed A Khadeer
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 284:C1633-44. 2003
    ..type IIa Na/P(i) cotransporter (Npt2a) in osteoclast lysates interacts with the Na/H exchanger regulatory factor, NHERF-1, a PDZ protein that is essential for the regulation of various membrane transporters...
  95. pmc Regulation of expression of microvillus membrane proteins by estrogen in baboon fetal ovarian oocytes
    Nicholas C Zachos
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Biol Reprod 79:1160-8. 2008
    ..Phosphorylated ezrin and Na+/H+ exchange regulatory factor 1 (NHERF, now termed SLC9A3R1) link f-actin bundles to the membrane, whereas alpha-actinin cross-links f-actin to form microvilli...
  96. pmc Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling
    Blair Hopwood
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia, 5000, Australia
    Arthritis Res Ther 9:R100. 2007
    ..Other differentially expressed genes included WNT (WNT5B, NHERF1, CTNNB1 and PTEN) and TGF-beta/BMP (TGFB1, SMAD3, BMP5 and INHBA) signalling pathway component or modulating genes...
  97. ncbi Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:37815-21. 2004
    The present experiments using primary cultures of renal proximal tubule cells derived from wild-type and NHERF-1 knockout animals examines the regulation of NHE3 by phenylthiohydantoin (PTH) and the regulation of phosphate transport in ..
  98. pmc Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF
    Jean Baptiste Demoulin
    Ludwig Institute for Cancer Research, Box 595, SE 75124 Uppsala, Sweden
    Biochem J 376:505-10. 2003
    ..We identified two PDZ domain proteins, namely NHERF (Na(+)/H(+) exchanger regulatory factor, also called EBP50) and NHERF2 (E3KARP, SIP-1, TKA-1), which have been shown previously to associate with the murine PDGF receptor [..
  99. pmc The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface
    Cheri S Lazar
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0650, USA
    Mol Biol Cell 15:5470-80. 2004
    ..We have identified the Na(+)/H(+) exchanger regulatory factor (NHERF) as an important molecular component that stabilizes epidermal growth factor receptors (EGFRs) at the cell surface ..
  100. ncbi Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions
    L Fouassier
    Division of Gastroenterology and Hepatology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 275:25039-45. 2000
    Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 (EBP50) is a versatile membrane-cytoskeleton linking protein that binds to the COOH-tail of specific integral membrane proteins through its two PDZ domains...
  101. ncbi Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor
    Kerry L Hildreth
    Department of Medicine Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:41775-82. 2004
    ..GRK2-mediated phosphorylation on the association of the PDGFRbeta with the Na(+)/H(+) exchanger regulatory factor (NHERF), a protein shown to potentiate dimerization of the PDGFRbeta, but not the EGFR...

Research Grants102 found, 100 shown here

  1. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2010
    ..We will study these effects on the NHE inhibitory protein-2 (NHERF-2) in vivo in the microperfused proximal tubules of WKY and SHR, by the addition of drugs to the perfusates, or ..
  2. PTH1R SIGNALING BY CYTOPLASMIC BINDING PARTNERS
    WILLIAM SNEDDON; Fiscal Year: 2005
    ..and how it is regulated by cytoplasmic adaptor proteins such as the sodium/hydrogen exchanger regulatory factor 1 (NHERF1), also known as the ezrin binding protein of 50 kDa (EBP50)...
  3. NHERFs Specify PTH Receptor Signaling
    Harald Juppner; Fiscal Year: 2005
    ..PLCbeta through PDZ domain-specific interactions; PLbeta beta 1 and 2 bind to PDZ1 and PTH1R binds to PDZ2 of both NHERF1 and 2...
  4. NHERF-1 and PTH regulation of the renal transport of phosphate.
    Edward J Weinman; Fiscal Year: 2010
    The Sodium-Hydrogen Exchanger Regulatory Factor-1 (NHERF-1) is an adaptor protein containing two protein-interactive PDZ domains and a C-terminal ERM binding domain that localizes to the brush border membrane of renal proximal ..
  5. A role for EPI64 in microvilli organization
    DAVID LALONDE; Fiscal Year: 2007
    ..In aim 2, the direct association between EPI64 and Arf6, as well as the EPI64 binding partners EBP50 and ezrin (which binds through EBP50) will be examined using purified proteins to determine if their direct binary ..
  6. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2006
    ..follow changes in the expression and localization of cell-specific proteins and mRNA (V-ATPase subunit, AE1, AE4, NHERF, AQP2, AQP4, V2R) during cell remodeling...
  7. Na+-H+ Transport in Renal Apical Membranes
    Edward Weinman; Fiscal Year: 2006
    ..NHE3 (sodium hydrogen exchanger 3) and Npt2 (sodium phosphate cotransporter Ila) involve the PDZ proteins NHERF-1 and NHERF-2 (sodium hydrogen exchanger regulatory factors) that bind to these transporters and transduce ..
  8. PTH RECEPTOR: FUNCTION MEETS FORM
    Peter A Friedman; Fiscal Year: 2010
    ..One such adapter protein, NHERF1, governs these effects...
  9. REGULATION OF CFTR TRAFFICKING
    BRUCE STANTON; Fiscal Year: 2002
    ..C-terminus retains CFTR in the apical plasma membrane; and (4) Test the hypothesis that ezrin binding protein 50 (EBP50) and other proteins containing PDZ domains interact with and localized CFTR to the apical membrane...
  10. Cellular Pharmacology of Kappa Opioid Receptor
    Lee Yuan Liu Chen; Fiscal Year: 2007
    ..The central hypothesis of this application is that the hkor is associated with EBP50/NHERF-1 and GABARAPL1 and undergoes ubiquitination, all of which play important roles in the regulation, ..
  11. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2007
    ..Activated ezrin binds EBP50, a scaffolding protein with two PDZ domains that bind to many different transmembrane proteins, and a C-terminal ..
  12. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony P Bretscher; Fiscal Year: 2010
    ..Activated ezrin binds EBP50, a scaffolding protein with two PDZ domains that bind to many different transmembrane proteins, and a C-terminal ..
  13. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2006
    ..interaction, has been found to unmask binding sites for F-actin and membrane associated proteins, including EBP50, a protein that binds ezrin through a carboxyl-terminal sequence...
  14. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2002
    ..A protein, EBP50, was identified that binds ezrin and has two PDZ domains that are predicted to interact with the C-terminal tails ..
  15. The Role Of Osteoclast PODXL, A Mediator Of Cell Adhesion, In Bone Metabolism
    Merry Jo Oursler; Fiscal Year: 2010
    ..hypothesis that early progenitor membrane expression levels of a PODXL membrane complex including CXCR4 and NHERF1 must be reduced to allow for precursor fusion and lower levels of this complex are required for activation of ..
  16. NHERF2 Directly Mediates PTH/PTHrP Receptor Signaling
    MATTHEW MAHON; Fiscal Year: 2004
    ..Phospholipase Cbeta1 and beta2 interact with NHERF proteins...
  17. Cell Biology of CFTR in Polarized Epithelia
    James Collawn; Fiscal Year: 2003
    ..wild type CFTR is stabilized at the cell surface through interactions with epithelial-specific proteins such as EBP50, is internalized through clathrincoated pits because of sorting signals in its cytoplasmic tail regions, and is ..
  18. Cell Biology of CFTR in Polarized Epithelia
    James Collawn; Fiscal Year: 2006
    ..wild type CFTR is stabilized at the cell surface through interactions with epithelial-specific proteins such as EBP50, is internalized through clathrincoated pits because of sorting signals in its cytoplasmic tail regions, and is ..
  19. Cell Biology of CFTR in Polarized Epithelia
    James Collawn; Fiscal Year: 2007
    ..wild type CFTR is stabilized at the cell surface through interactions with epithelial-specific proteins such as EBP50, is internalized through clathrin- coated pits because of sorting signals in its cytoplasmic tail regions, and is ..
  20. PDZ scaffold regulation of astrocytic glutamate receptors and transporters
    Randy Hall; Fiscal Year: 2009
    ..EAAT1 all exhibit robust and specific interactions with the PDZ domains of the multifunctional scaffold protein NHERF-2...
  21. PDZ scaffold regulation of astrocytic glutamate receptors and transporters
    Randy A Hall; Fiscal Year: 2010
    ..EAAT1 all exhibit robust and specific interactions with the PDZ domains of the multifunctional scaffold protein NHERF-2...
  22. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2010
    ..pathways mediating this effect will be investigated using both in vitro and in vivo studies involving PDZK1 and NHERF1 knout mice...
  23. HEPATIC ORGANIC ANION UPTAKE AND TRANSPORT
    Allan W Wolkoff; Fiscal Year: 2010
    ..In further studies, we showed that PDZK1 can bind to EBP50 (NHERF-1), a protein with two independent PDZ consensus binding sites...
  24. MOLECULAR PATHOGENESIS OF HYPOPHOSPHATEMIC RICKETS
    Suzanne M Jan De Beur; Fiscal Year: 2010
    ..involving NaPi-lla and signaling molecules on the scaffold of Sodium hydrogen ion exchanger related factor-1 (NHERF-1) that interacts with the actin cytoskeleton...
  25. MOLECULAR PATHOGENESIS OF HYPOPHOSPHATEMIC RICKETS
    Suzanne Jan de Beur; Fiscal Year: 2009
    ..involving NaPi-lla and signaling molecules on the scaffold of Sodium hydrogen ion exchanger related factor-1 (NHERF-1) that interacts with the actin cytoskeleton...
  26. Keeping CFTR in its Place: An Integrated Small-Molecule Approach
    Dean R Madden; Fiscal Year: 2010
    ..degradation of CFTR;and (3) Degradation can also be blocked by overexpression of another CFTR-binding protein, NHERF1. We have assembled a highly collaborative team with unique and complementary skills...
  27. Keeping CFTR in its Place: An Integrated Small-Molecule Approach
    DEAN MADDEN; Fiscal Year: 2009
    ..degradation of CFTR; and (3) Degradation can also be blocked by overexpression of another CFTR-binding protein, NHERF1. We have assembled a highly collaborative team with unique and complementary skills...
  28. Modulation of NHE Activity by EPEC Infection
    Pradeep Dudeja; Fiscal Year: 2006
    ..modulation of NHE isoform activities by elucidating signaling pathways involved, the role of regulatory factors NHERF1 and NHERF2), the role of the cytoskeletal protein ezrin, and NHE membrane trafficking; 3...
  29. SODIUM-H+ TRANSPORT IN RENAL APICAL MEMBRANES
    Edward Weinman; Fiscal Year: 2002
    ..NHE-RF binds to NHERF, to NHE3, and to ezrin suggesting that NHE-RF interacts uniquely with its cellular targets forming signaling-..
  30. Cytoskeletal linking proteins in renal epithelial cell function
    R Brian Doctor; Fiscal Year: 2010
    ..NaPiIIa activity is influence by its direct interaction with a number of distinct PDZ proteins, including EBP50 and PDZK1. These proteins appear to influence the delivery and retention of NaPiIIa in the apical membrane...
  31. Cytoskeletal linking proteins in renal epithelial cell function
    R Brian Doctor; Fiscal Year: 2010
    ..NaPiIIa activity is influence by its direct interaction with a number of distinct PDZ proteins, including EBP50 and PDZK1. These proteins appear to influence the delivery and retention of NaPiIIa in the apical membrane...
  32. Cytoskeletal Linking Proteins in Liver Function
    R Brian Doctor; Fiscal Year: 2006
    ..In epithelial cells, Ezrin-Radixin-Moesin binding phosphoprotein 50 (EBP50) has been implicated in modulating cAMP-dependent apical transport events...
  33. Bacteria-Epithelial Cell Cytoskeleton Interaction
    Steven Brody; Fiscal Year: 2007
    ..was characterized by decreased apical localization of cytoskeletal scaffolding ERM family and PDZ-domain NHERF/EBP50 proteins and disrupted cilia basal bodies. We hypothesize that (1) the airway epithelial cell responses to P...