Gene Symbol: SLC8A1
Description: solute carrier family 8 member A1
Alias: NCX1, sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Na+/Ca++ exchanger, Na+/Ca2+ exchanger, solute carrier family 8 (sodium/calcium exchanger), member 1, solute carrier family 8 member 1
Species: human
Products:     SLC8A1

Top Publications

  1. Lencesova L, O Neill A, Resneck W, Bloch R, Blaustein M. Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes. J Biol Chem. 2004;279:2885-93 pubmed
    ..Na(+)/Ca(2+) exchanger type 1 (NCX1), a key PM Ca(2+) transporter, was immunoprecipitated from the detergent-soluble fraction...
  2. Rosker C, Graziani A, Lukas M, Eder P, Zhu M, Romanin C, et al. Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem. 2004;279:13696-704 pubmed
    ..b>NCX1 immunoreactivity was detectable in HEK293 as well as in TRPC3-overexpressing HEK293 cells, and reduction of ..
  3. Kokubo Y, Inamoto N, Tomoike H, Kamide K, Takiuchi S, Kawano Y, et al. Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population. Hypertens Res. 2004;27:697-702 pubmed
    ..Therefore, we examined whether genetic variations in NCX1 were associated with hypertension...
  4. Hurtado C, Prociuk M, Maddaford T, Dibrov E, Mesaeli N, Hryshko L, et al. Cells expressing unique Na+/Ca2+ exchange (NCX1) splice variants exhibit different susceptibilities to Ca2+ overload. Am J Physiol Heart Circ Physiol. 2006;290:H2155-62 pubmed
    The Na+/Ca2+ exchanger (NCX) NCX1 exhibits tissue-specific alternative splicing. Such NCX splice variants as NCX1.1 and NCX1...
  5. Liu B, Peel S, Fox J, Hall I. Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation. Respir Res. 2010;11:168 pubmed publisher
    ..b>NCX1 protein was detected in cultured human bronchial smooth muscle cells (HBSMC) cells and NCX1...
  6. Kraev A, Chumakov I, Carafoli E. The organization of the human gene NCX1 encoding the sodium-calcium exchanger. Genomics. 1996;37:105-12 pubmed
    The intron-exon organization of the human Na/Ca-exchanger gene NCX1 and of the N-terminal half of the related gene NCX2 has been determined...
  7. Iwamoto T, Kita S, Zhang J, Blaustein M, Arai Y, Yoshida S, et al. Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Nat Med. 2004;10:1193-9 pubmed
    ..Here we identify the role of Na(+)/Ca(2+) exchanger type 1 (NCX1) in salt-sensitive hypertension using SEA0400, a specific inhibitor of Ca(2+) entry through NCX1, and genetically ..
  8. Shah S, Akhtar M, Hassan M, Akhtar M, Paudel Y, Najmi A. EGFR tyrosine kinase inhibition decreases cardiac remodeling and SERCA2a/NCX1 depletion in streptozotocin induced cardiomyopathy in C57/BL6 mice. Life Sci. 2018;210:29-39 pubmed publisher
    ..Decreased sarcoplasmic endoplasmic reticulum Ca2 + ATPase2a (SERCA2a) and sodium‑calcium exchanger-1 (NCX1) protein depletion after gefitinib administration indicated improved Ca2+ homeostasis during myocardial ..
  9. Qiu Z, Zhang W, Fan F, Li H, Wu C, Ye Y, et al. Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive rats via PKCα/β2 signal pathway. J Cell Mol Med. 2012;16:3052-61 pubmed publisher
    ..measured; the expressions of SERCA-2a, phospholamban (PLB), ryanodine receptor2 (RyR2), sodium-calcium exchanger 1 (NCX1), Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and protein phosphatase inhibitor-1 (PPI-1) were detected ..

More Information

Publications137 found, 100 shown here

  1. Sahraoui A, Dewachter C, de Medina G, Naeije R, Aouichat Bouguerra S, Dewachter L. Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils. PLoS ONE. 2016;11:e0148117 pubmed publisher
    ..Myocardial expressions of ryanodine receptor, phospholamban and sodium/calcium exchanger (Slc8a1) did not change...
  2. Das S, Zhabyeyev P, Basu R, Patel V, Dyck J, Kassiri Z, et al. Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy. Biosci Rep. 2018;38: pubmed publisher
    ..and resveratrol therapy restored SERCa2a levels and suppressed up-regulation of the sodium-calcium exchanger (NCX1)...
  3. Kunert Keil C, Gredes T, Lucke S, Botzenhart U, Dominiak M, Gedrange T. Differential expression of genes involved in the calcium homeostasis in masticatory muscles of MDX mice. J Physiol Pharmacol. 2014;65:317-24 pubmed
    ..ATPases SERCA1 and SERCA2, the plasma membrane Ca(2+) ATPases Atp2b1 and Atp2b4, the sodium/calcium exchanger NCX1, the ryanodine receptor 1, parvalbumin, sarcolipin, phospholamban and the L-type Ca(2+) channel alpha-1 subunit (..
  4. Liu C, Shao G, Lu Y, Xue M, Liang F, Zhang Z, et al. Parathyroid Hormone-Related Protein (1-40) Enhances Calcium Uptake in Rat Enterocytes Through PTHR1 Receptor and Protein Kinase Cα/β Signaling. Cell Physiol Biochem. 2018;51:1695-1709 pubmed publisher
    ..transporter proteins, potential vanilloid member 6 (TRPV6), calbindin-D9k (CaBP-D9k), sodium-calcium exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1), in a dose- and time-dependent manner...
  5. Yu Y, Yi X, Mei Z, Li J, Huang X, Yang G, et al. The water extract of Veratrilla baillonii could attenuate the subacute toxicity induced by Aconitum brachypodum. Phytomedicine. 2016;23:1591-1598 pubmed publisher
    ..the metabolic enzymes CYP3A1 and CYP3A2 in liver, downregulating the expression of Sodium/Calcium exchanger 1 (NCX1) and SCN5A sodium channal mRNA, and inducing Na+/K+-ATPase activity in heart...
  6. Fourbon Y, Gueguinou M, Felix R, Constantin B, Uguen A, Fromont G, et al. Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity. Sci Rep. 2017;7:14199 pubmed publisher
    ..cancer cell line and modified the cytosolic Ca2+ oscillations induced by the sodium/calcium exchanger NCX1/3 working in its reverse mode...
  7. Liu F, Lu M, Patel N, Schillinger K, Wang T, Patel V. GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function. Circ Cardiovasc Genet. 2015;8:284-93 pubmed publisher
    ..also associated with downregulation of the transcriptional repressor ID2 and the cardiac sodium-calcium exchanger NCX1 in the proximal CCS, where GATA6 transactivates both of these factors...
  8. Cerullo P, Brancaccio P, Anzilotti S, Vinciguerra A, Cuomo O, Fiorino F, et al. Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia. Neuropharmacology. 2018;135:180-191 pubmed publisher
    ..Hypoxic-ischemic insult induced a reduction of NCX1 and NCX3 expression starting from day 7 until day 60...
  9. Zhao H, Song X, Yan L, Ren M, Cui X, Li Y, et al. IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p. Biochim Biophys Acta Mol Basis Dis. 2018;1864:189-196 pubmed publisher
    ..shows a novel mechanism involving IgE, Fc?R1, miRNA-212-5p (miR-212-5p), and sodium/calcium exchanger protein 1(NCX1) for asthma to induce hypotension...
  10. Bastioli G, Piccirillo S, Castaldo P, Magi S, Tozzi A, Amoroso S, et al. Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity. Cell Death Dis. 2019;10:80 pubmed publisher
    ..Of note, using a siRNA approach, we found that NCX1 was the isoform specifically involved...
  11. Xiang J, Guo R, Wan C, Wu L, Yang S, Guo D. Regulation of Intestinal Epithelial Calcium Transport Proteins by Stanniocalcin-1 in Caco2 Cells. Int J Mol Sci. 2016;17: pubmed publisher
    ..vanilloid members (TRPV) 5 and 6, the plasma membrane calcium ATPase 1b (PMCA1b), the sodium/calcium exchanger (NCX1), and the vitamin D receptor (VDR)...
  12. Yu X, Zhao X, Bao R, Yu J, Zhang G, Chen J. The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats. BMC Complement Altern Med. 2017;17:330 pubmed publisher
    ..accompanied with higher ratio of infarct size to risk size, decreased expressions of sodium calcium exchanger (NCX1) and sarcoplasmic reticulum Ca2+-ATPase (Serca2a), and different expressions of autophagic proteins, ..
  13. Zup S, Edwards N, McCarthy M. Sex- and age-dependent effects of androgens on glutamate-induced cell death and intracellular calcium regulation in the developing hippocampus. Neuroscience. 2014;281:77-87 pubmed publisher
    ..quantified three calcium regulatory proteins, plasma membrane calcium ATPase1 (PMCA1), sodium/calcium exchanger1 (NCX1), and the sarco/endoplasmic reticulum calcium ATPase 2 (SERCA2)...
  14. Szadvari I, Hudecova S, Chovancova B, Matuskova M, Cholujova D, Lencesova L, et al. Sodium/calcium exchanger is involved in apoptosis induced by H2S in tumor cells through decreased levels of intracellular pH. Nitric Oxide. 2019;87:1-9 pubmed publisher
    We explored possibility that sodium/calcium exchanger 1 (NCX1) is involved in pH modulation and apoptosis induction in GYY4137 treated cells...
  15. Giladi M, Lee S, Ariely Y, Teldan Y, Granit R, Strulovich R, et al. Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms. Sci Rep. 2017;7:993 pubmed publisher
    Mammalian Na+/Ca2+ exchangers, NCX1 and NCX3, generate splice variants, whereas NCX2 does not...
  16. Song S, Tang G, Tang L, Si L, Xiong W. NAKα2 inhibits fibrosis formation and protects against cardiomyocyte hypertrophy by suppressing hypertrophy associated molecules and activating LTCC/NCX signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23:3021-3033 pubmed publisher
    ..Over-expression of NKAα2 suppressed fibrosis formation and protected against cardiomyocyte hypertrophy by inhibiting hypertrophy associated molecules, alleviating apoptosis and activating LTCC/NCX signaling pathway. ..
  17. Liu A, Bao Y, Wang X, Zhang Z. Cardio-protection by Ginkgo biloba extract 50 in rats with acute myocardial infarction is related to Na⁺-Ca²⁺ exchanger. Am J Chin Med. 2013;41:789-800 pubmed publisher
    ..GBE50 could improve recovery in contractile function and prevent myocardium from ischemia damage, which may be caused by attenuating the abnormal expression of NCX. ..
  18. Dong Q, Wu Z, Li X, Yan J, Zhao L, Yang C, et al. Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca(2+) cycling proteins. J Transl Med. 2014;12:323 pubmed publisher
    ..and ryanodine receptor 2 (RyR2), hypophosphorylated phospholamban (PLB), upregulation of Na(+)/Ca(2+)-exchangers (NCX1) and increased expression and phosphorylation of Ca(2+)/calmodulin -dependent protein kinase II (CaMKII)...
  19. Zhao F, Fu L, Yang W, Dong Y, Yang J, Sun S, et al. Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro. Life Sci. 2016;145:213-23 pubmed publisher
    ..of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and expression of Na(+)/Ca(2+)-exchangers (NCX1), upregulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) and ryanodine receptor 2 (RYR2)...
  20. Bai X, Hao J, Wang J, Zhang W, Yan C, Zhao J, et al. Curcumin inhibits cardiac hypertrophy and improves cardiovascular function via enhanced Na+/Ca2+ exchanger expression after transverse abdominal aortic constriction in rats. Pharmacol Rep. 2018;70:60-68 pubmed publisher
  21. Wu P, Xie F, Xue M, Xu X, He S, Lin M, et al. Advanced oxidation protein products decrease the expression of calcium transport channels in small intestinal epithelium via the p44/42 MAPK signaling pathway. Eur J Cell Biol. 2015;94:190-203 pubmed publisher
    ..vanilloid [TRPV6], calbindin-D9k [CaBP-D9k], plasma membrane Ca(2+)-ATPase 1 [PMCA1], and Na(+)/Ca(2+) exchanger 1 [NCX1]) were decreased...
  22. Huang S, Chen Y, Kao Y, Hsieh M, Chen Y, Chen W, et al. Renal failure induces atrial arrhythmogenesis from discrepant electrophysiological remodeling and calcium regulation in pulmonary veins, sinoatrial node, and atria. Int J Cardiol. 2016;202:846-57 pubmed publisher
    ..Advanced RF increases atrial arrhythmia by modulating the distinctive electrophysiological characteristics of the PV, LA, and SAN. ..
  23. Lugenbiel P, Wenz F, Govorov K, Schweizer P, Katus H, Thomas D. Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. PLoS ONE. 2015;10:e0116395 pubmed publisher
    ..The changes may provide a starting point for personalized approaches to AF treatment. ..
  24. Meurer M, Hocherl K. Renal ischemia-reperfusion injury impairs renal calcium, magnesium, and phosphate handling in mice. Pflugers Arch. 2019;: pubmed publisher transcellular transport of Ca2+, Mg2+, and Pi (calbindin-D28K, Ncx1, Pmca4, Cnnm2, Trpm7, NaPi-2a, and NaPi-2c) was observed...
  25. Zhang Y, Sharma S, Lytton J. Anatomical evidence for a non-synaptic influence of the K+ -dependent Na+/Ca2+ -exchanger, NCKX2, on hippocampal plasticity. Neuroscience. 2015;310:372-88 pubmed publisher
  26. Zhang Y, Chen A, Song L, Li M, Luo Z, Zhang W, et al. Low-Level Vagus Nerve Stimulation Reverses Cardiac Dysfunction and Subcellular Calcium Handling in Rats With Post-Myocardial Infarction Heart Failure. Int Heart J. 2016;57:350-5 pubmed publisher
    ..restored the protein and mRNA levels of sarcoplasmic reticulum Ca(2+) ATPase (SERCA2a), Na(+)-Ca(2+) exchanger 1 (NCX1), and phospholamban (PLB) whereas the expression of ryanodine receptor 2 (RyR2) as well as mRNA level was ..
  27. Ferdous Z, Qureshi M, Jayaprakash P, Parekh K, John A, Oz M, et al. Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat. PLoS ONE. 2016;11:e0153934 pubmed publisher
    ..some other proteins were significantly upregulated in STZ-SAN: gap junction, Gjc1; cell membrane transport, Slc8a1, Trpc1, Trpc6 (4-fold); intracellular Ca2+-transport, Ryr3; calcium channel Cacna1g, Cacna1h, Cacnb3; potassium ..
  28. Das S, Patel V, Basu R, Wang W, Desaulniers J, Kassiri Z, et al. Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Ovariectomy prevented iron-induced upregulation of ferritin, decreased myocardial SERCA2a levels, and increased NCX1 levels. 17?-Estradiol therapy rescued the iron-overload cardiomyopathy in male wild-type mice...
  29. Smith S, Sturm A, Curran J, Kline C, Little S, Bonilla I, et al. Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation. 2015;131:695-708 pubmed publisher
    ..Our findings identify βII spectrin as critical for normal myocyte electric activity, link this molecule to human disease, and provide new insight into the mechanisms underlying cardiac myocyte biology. ..
  30. Zhang H, Cannell M, Kim S, Watson J, Norman R, Calaghan S, et al. Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload. PLoS ONE. 2015;10:e0144309 pubmed publisher
    ..The incidence and frequency of spontaneous Ca2+-transients following rapid-pacing (4 Hz) was greater in AoB than in Sham myocytes. In conclusion, elevated afterload causes cellular hypertrophy and remodeling of atrial SR Ca2+-release. ..
  31. Lichvárová L, Lacinová Ä. Ca(V)1.2 and Ca(V)1.3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells. Gen Physiol Biophys. 2015;34:157-65 pubmed publisher
    ..2 or to Ca(V)1.3 channel subtypes contributes to maintenance of the resting membrane potentials of NGF-differentiated PC12 cells but is not required for regulation of expression of genes for calcium-transporting proteins. ..
  32. Wongdee K, Charoenphandhu N. Vitamin D-enhanced duodenal calcium transport. Vitam Horm. 2015;98:407-40 pubmed publisher
    ..g., TRPV5/6, calbindin-D9k, plasma membrane Ca(2+)-ATPase1b, and NCX1, thereby enhancing the transcellular calcium transport...
  33. Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, et al. Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice. Neuropharmacology. 2018;131:291-303 pubmed publisher
    ..Three mammalian NCX isoforms (NCX1, NCX2, and NCX3) are each encoded by a distinct gene...
  34. Wu M, Wu D, Wang C, Guo Z, Li B, Zuo Z. Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2.5. J Hazard Mater. 2016;302:304-313 pubmed publisher
    ..HBCD exposure induced an arrhythmogenic disorder, which was triggered by the imbalance of Ryr2, Serca2a and Ncx1 expression, inducing Ca(2+) overload in the sarcoplasmic reticulum and high Ca(2+)-ATPase activities in the H9C2 ..
  35. Carvill G, Weckhuysen S, McMahon J, Hartmann C, Møller R, Hjalgrim H, et al. GABRA1 and STXBP1: novel genetic causes of Dravet syndrome. Neurology. 2014;82:1245-53 pubmed publisher
    ..Our results have important implications for diagnostic testing, clinical management, and genetic counseling of patients with this devastating disorder and their families. ..
  36. Bögeholz N, Pauls P, Bauer B, Schulte J, Dechering D, Frommeyer G, et al. Suppression of Early and Late Afterdepolarizations by Heterozygous Knockout of the Na+/Ca2+ Exchanger in a Murine Model. Circ Arrhythm Electrophysiol. 2015;8:1210-8 pubmed publisher
    ..This is the first study to demonstrate that genetic inhibition of NCX protects against afterdepolarizations and to investigate the underlying mechanisms. ..
  37. Yamashita K, Watanabe Y, Kita S, Iwamoto T, Kimura J. Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:1205-1214 pubmed
    ..The potency of YM-244769 as an NCX1 inhibitor is higher than those of KB-R7943 and SN-6 and is similar to that of SEA0400.
  38. Despa S, Bers D. Na? transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol. 2013;61:2-10 pubmed publisher
    ..This article is part of a Special Issue entitled "Na(+) Regulation in Cardiac Myocytes." ..
  39. Bögeholz N, Pauls P, Kaese S, Schulte J, Lemoine M, Dechering D, et al. Triggered activity in atrial myocytes is influenced by Na+/Ca2+ exchanger activity in genetically altered mice. J Mol Cell Cardiol. 2016;101:106-115 pubmed publisher
    ..These findings indicate that the level of NCX activity could influence triggered activity in atrial myocytes independent of possible remodeling processes. ..
  40. Wagner S, Maier L, Bers D. Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death. Circ Res. 2015;116:1956-70 pubmed publisher
    ..This review addresses basic tachyarrhythmic mechanisms, the underlying ionic mechanisms and the consequences for ion homeostasis, and the situation in complex diseases like heart failure. ..
  41. Lagrutta A, Zeng H, Imredy J, Balasubramanian B, Dech S, Lis E, et al. Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells. Toxicol Appl Pharmacol. 2016;308:66-76 pubmed publisher
    ..Ryanodine and thapsigargin, decreasing intracellular Ca(2+) stores, and SEA-0400, a Na(+)/Ca(2+) exchanger-1 (NCX1) inhibitor, partially antagonized or suppressed DDI effects...
  42. Schulte J, Fehrmann E, Tekook M, Kranick D, Fels B, Li N, et al. Cardiac expression of the CREM repressor isoform CREM-IbΔC-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016;111:15 pubmed publisher
    ..As a likely cause we discovered enhanced NCX-mediated Ca(2+) transport and NCX1 protein level in TG...
  43. Chu L, Greenstein J, Winslow R. Modeling Na+-Ca2+ exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling. J Mol Cell Cardiol. 2016;99:174-187 pubmed publisher
    The cardiac sodium (Na+)/calcium (Ca2+) exchanger (NCX1) is an electrogenic membrane transporter that regulates Ca2+ homeostasis in cardiomyocytes, serving mainly to extrude Ca2+ during diastole...
  44. Xu J, Yang Y, Xie R, Liu J, Nie X, An J, et al. The NCX1/TRPC6 Complex Mediates TGF?-Driven Migration and Invasion of Human Hepatocellular Carcinoma Cells. Cancer Res. 2018;78:2564-2576 pubmed publisher
    ..In this study, we investigated the roles of Na+/Ca2+ exchanger 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) in regulating TGF? in human HCC...
  45. Moonga B, Davidson R, Sun L, Adebanjo O, Moser J, Abedin M, et al. Identification and characterization of a sodium/calcium exchanger, NCX-1, in osteoclasts and its role in bone resorption. Biochem Biophys Res Commun. 2001;283:770-5 pubmed
    ..Together, the results suggest that a functional NCX, likely NCX-1, is involved in the regulation of osteoclast cytosolic Ca2+ and bone resorption. ..
  46. Yilmaz E, Gold M. Paclitaxel-induced increase in NCX activity in subpopulations of nociceptive afferents: A protective mechanism against chemotherapy-induced peripheral neuropathy?. Cell Calcium. 2016;60:25-31 pubmed publisher
    ..blocker KB-R7943, the increase in NCX activity in thigh neurons was resistant to KB-R7943 but sensitive to the NCX1-preferring blocker SEA0400...
  47. Matsui M, Kuraishi N, Eto K, Hamidy A, Nishikawa K, Shimada T, et al. Unusually high genetic diversity in the Bornean Limnonectes kuhlii-like fanged frogs (Anura: Dicroglossidae). Mol Phylogenet Evol. 2016;102:305-19 pubmed publisher
    ..using 2517bp sequences of the 12S rRNA, tRNA(val), and 16S rRNA of mitochondrial DNA, and 2367bp sequences of the NCX1, POMC, and RAG1 of nuclear genes. In the mtDNA trees, Bornean L...
  48. Colvin R, Bennett J, Colvin S, Allen R, Martinez J, Miner G. Na+/Ca2+ exchange activity is increased in Alzheimer's disease brain tissues. Brain Res. 1991;543:139-47 pubmed
    ..abstract truncated at 250 words) ..
  49. Wu G, Xie X, Lu Z, Ledeen R. Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum. Proc Natl Acad Sci U S A. 2009;106:10829-34 pubmed publisher
    ..They also suggest a possible contributory mechanism for independent regulation of nuclear Ca(2+). ..
  50. Yue X, Zhang R, Kim B, Ma A, Philipson K, Goldhaber J. Heterogeneity of transverse-axial tubule system in mouse atria: Remodeling in atrial-specific Na+-Ca2+ exchanger knockout mice. J Mol Cell Cardiol. 2017;108:50-60 pubmed publisher
    ..We conclude that the remodeling of NCX KO atrial myocytes is accompanied by a loss of TATs leading to abnormal Ca release and uptake that could impact atrial contractility and rhythm. ..
  51. Plain F, Congreve S, Yee R, Kennedy J, Howie J, Kuo C, et al. An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger. J Biol Chem. 2017;292:10745-10752 pubmed publisher
    ..The aim of this investigation was to identify the structural determinants of NCX1 palmitoylation...
  52. van der Hagen E, van Loon E, Verkaart S, Latta F, Bindels R, Hoenderop J. The Na+/Ca2+ Exchanger 1 (NCX1) Variant 3 as the Major Extrusion System in Renal Distal Tubular Transcellular Ca2+-Transport. Nephron. 2015;131:145-52 pubmed publisher
    ..basolateral side by the concerted actions of the plasma membrane Ca(2+) ATPases and the Na(+)/Ca(2+) exchanger 1 (NCX1). NCX1 is responsible for ∼ 70% of basolateral Ca(2+) extrusion...
  53. Sharma V, Roy S, Sekler I, O Halloran D. The NCLX-type Na+/Ca2+ Exchanger NCX-9 Is Required for Patterning of Neural Circuits in Caenorhabditis elegans. J Biol Chem. 2017;292:5364-5377 pubmed publisher
    ..Taken together, our work reveals the specificity by which the handling by NCLX of calcium exchange can map to neural circuit patterning and axon guidance decisions during development. ..
  54. Ruknudin A, Valdivia C, Kofuji P, Lederer W, Schulze D. Na+/Ca2+ exchanger in Drosophila: cloning, expression, and transport differences. Am J Physiol. 1997;273:C257-65 pubmed
    ..The overall deduced protein structure for Dmel/Nck is similar to that of mammalian Na+/Ca2+ exchanger genes NCX1 and NCX2, having six hydrophobic regions in the amino terminus separated from six at the carboxy-terminal end by a ..
  55. Su Z, Yao A, Zubair I, Sugishita K, Ritter M, Li F, et al. Effects of deletion of muscle LIM protein on myocyte function. Am J Physiol Heart Circ Physiol. 2001;280:H2665-73 pubmed
    ..Thus a reduced [Ca2+]-induced shortening may be involved in the pathogenesis of myocardial dysfunction in this genetic model of heart failure...
  56. Costain G, Lionel A, Ogura L, Marshall C, Scherer S, Silversides C, et al. Genome-wide rare copy number variations contribute to genetic risk for transposition of the great arteries. Int J Cardiol. 2016;204:115-21 pubmed publisher
    ..and novel candidate susceptibility genes identified included ACKR3, IFT57, ITGB8, KL, NF1, NKX1-2, RERE, SLC8A1, SOX18, and ULK1. These data demonstrate a genome-wide role for rare CNVs in genetic risk for TGA...
  57. Tang G, Shen Y, GAO P, Song S, Si L. Klotho attenuates isoproterenol-induced hypertrophic response in H9C2 cells by activating Na+/K+-ATPase and inhibiting the reverse mode of Na+/Ca2+-exchanger. In Vitro Cell Dev Biol Anim. 2018;54:250-256 pubmed publisher
  58. Douglas L, McGuire A, Manzardo A, Butler M. High-resolution chromosome ideogram representation of recognized genes for bipolar disorder. Gene. 2016;586:136-47 pubmed publisher
    ..g., HTR1A, HTR2A, HTR3B) neurotransmission; molecular transporters (e.g., SLC39A3, SLC6A3, SLC8A1); and neuronal growth (e.g., BDNF, IGFBP1, NRG1, NRG3)...
  59. Le Page S, Niro M, Fauconnier J, Cellier L, Tamareille S, Gharib A, et al. Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+/- Mouse Model. PLoS ONE. 2016;11:e0164066 pubmed publisher
    ..Opa1 deficiency was associated with increased sensitivity to I/R, imbalance in dynamic mitochondrial Ca2+ uptake, and subsequent increase in NCX activity. ..
  60. Anzilotti S, Brancaccio P, Simeone G, Valsecchi V, Vinciguerra A, Secondo A, et al. Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+ exchanger 3 downregulation. Cell Death Dis. 2018;9:206 pubmed publisher
    ..These protective effects were mitigated in ncx3+/- mice. This study established for the first time an animal model of preconditioning in ALS and candidates NCX3 as a new therapeutic target. ..
  61. Zhang Z, Sun S, Du C, Li W, Zhang J, Zhu Y, et al. Effects of Leptin on Na+/Ca2+ Exchanger in PC12 Cells. Cell Physiol Biochem. 2016;40:1529-1537 pubmed publisher
    ..Na+/Ca2+-exchanger isoform NCX1 transcript levels and protein abundance were quantified by RT-PCR and Western blotting, respectively...
  62. Balasubramaniam S, Gopalakrishnapillai A, Petrelli N, Barwe S. Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. J Biol Chem. 2017;292:11388-11399 pubmed publisher
    ..We demonstrated earlier that Na+/Ca2+ exchanger 1 (NCX1), a major calcium exporter in renal epithelial cells, regulates epithelial cell motility...
  63. Wang M, Tan J, Miao Y, Li M, Zhang Q. Role of Ca²? and ion channels in the regulation of apoptosis under hypoxia. Histol Histopathol. 2018;33:237-246 pubmed publisher
    ..Hence, we aim to highlight the potential mechanisms of the main Ca²? channels in regulation of apoptosis under hypoxic stress. ..
  64. Magi S, Arcangeli S, Castaldo P, Nasti A, Berrino L, Piegari E, et al. Glutamate-induced ATP synthesis: relationship between plasma membrane Na+/Ca2+ exchanger and excitatory amino acid transporters in brain and heart cell models. Mol Pharmacol. 2013;84:603-14 pubmed publisher
    ..We expanded our studies on EAAT/NCX interplay in the H9c2 cells. H9c2 expresses EAATs but lacks endogenous NCX1 expression...
  65. Giladi M, van Dijk L, Refaeli B, Almagor L, Hiller R, Man P, et al. Dynamic distinctions in the Na+/Ca2+ exchanger adopting the inward- and outward-facing conformational states. J Biol Chem. 2017;292:12311-12323 pubmed publisher
  66. Xu J, Ji B, Wen G, Yang Y, Jin H, Liu X, et al. Na+/H+ exchanger 1, Na+/Ca2+ exchanger 1 and calmodulin complex regulates interleukin 6-mediated cellular behavior of human hepatocellular carcinoma. Carcinogenesis. 2016;37:290-300 pubmed publisher
    ..The inhibition of Na(+)/H(+) exchanger 1 (NHE1), Na(+)/Ca(2+) exchanger 1 (NCX1) and calmodulin (CaM) inhibited the IL6 stimulation-induced intracellular pH recovery increases and NH4Cl ..
  67. Charoenphandhu N, Kraidith K, Lertsuwan K, Sripong C, Suntornsaratoon P, Svasti S, et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice. Mol Cell Biochem. 2017;427:201-208 pubmed publisher
    ..totally abolished by inhibitors of the basolateral calcium transporters, Na+/Ca2+ exchanger (NCX1) and plasma membrane Ca2+-ATPase (PMCA1b), the enhanced calcium flux potentially occurred ..
  68. Shieh B, Xia Y, Sparkes R, Klisak I, Lusis A, Nicoll D, et al. Mapping of the gene for the cardiac sarcolemmal Na(+)-Ca2+ exchanger to human chromosome 2p21-p23. Genomics. 1992;12:616-7 pubmed
    ..with any genetic disorders of the heart or blood pressure, we have assigned the exchanger gene (designated NCX1) to human chromosome 2p21-p23 by analysis of a panel of mouse-human somatic cell hybrids and by in situ ..
  69. Larbig R, Reda S, Paar V, Trost A, Leitner J, Weichselbaumer S, et al. Through modulation of cardiac Ca2+ handling, UCP2 affects cardiac electrophysiology and influences the susceptibility for Ca2+ -mediated arrhythmias. Exp Physiol. 2017;102:650-662 pubmed publisher
    ..Although cardiac ryanodine receptor 2, NCX1, L-type Ca2+ channel (LTCC) and SERCA2a expression were not altered, Ucp2-/- mice revealed ..
  70. Khananshvili D. Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants. Adv Exp Med Biol. 2017;981:41-58 pubmed publisher
    Mammalian Na+/Ca2+ exchangers (NCX1, NCX2, and NCX3) and their splice variants are expressed in a tissue-specific manner and are regulated by Ca2+ binding CBD1 and CBD2 domains...
  71. Pachera N, Papin J, Zummo F, Rahier J, Mast J, Meyerovich K, et al. Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability. Diabetologia. 2015;58:2843-50 pubmed publisher
    ..We have shown that heterozygous inactivation of NCX1 in mice increased glucose-induced insulin release and stimulated beta cell proliferation and mass...
  72. Jiang M, Zhang M, Howren M, Wang Y, Tan A, Balijepalli R, et al. JPH-2 interacts with Cai-handling proteins and ion channels in dyads: Contribution to premature ventricular contraction-induced cardiomyopathy. Heart Rhythm. 2016;13:743-52 pubmed publisher
    ..Downregulation of JPH-2, BIN-1, and Cav1.2 plays a deterministic role in PVC-CM. Dissecting the hierarchical relationship among the three is necessary for the design of therapeutic interventions to prevent the progression of PVC-CM. ..
  73. He J, Cai Y, Luo L, Wang R. Expression of Wnt and NCX1 and its correlation with cardiomyocyte apoptosis in mouse with myocardial hypertrophy. Asian Pac J Trop Med. 2015;8:930-936 pubmed publisher
    To study the correlation between expression of Wnt and NCX1 and cardiomyocyte apoptosis in mouse with myocardial hypertrophy...
  74. Bossuyt J, Taylor B, James Kracke M, Hale C. Evidence for cardiac sodium-calcium exchanger association with caveolin-3. FEBS Lett. 2002;511:113-7 pubmed
    The interaction of cardiac Na+-Ca2+ exchange (NCX1) with caveolin proteins was investigated in sarcolemmal vesicles. Western blots of sarcolemmal vesicles revealed the presence of caveolin-1, -2, and -3...
  75. Yang H, Kim T, Lee H, Choi K, Jeung E. Distinct expression of the calcium exchangers, NCKX3 and NCX1, and their regulation by steroid in the human endometrium during the menstrual cycle. Reprod Sci. 2011;18:577-85 pubmed publisher
    ..The potassium-dependent sodium/calcium exchangers NCKX3 (gene SLC24A3) and NCX1 (gene SLC8A1) play a critical role in the transport of intracellular calcium across the cell membrane in exchange for ..
  76. Lubelwana Hafver T, Wanichawan P, Manfra O, de Souza G, Lunde M, Martinsen M, et al. Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). Proteomics. 2017;17: pubmed publisher
    ..Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1) is an antiporter membrane protein encoded by the SLC8A1 gene...
  77. Bögeholz N, Schulte J, Kaese S, Bauer B, Pauls P, Dechering D, et al. The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models. Front Pharmacol. 2017;8:649 pubmed publisher
    ..Thus, the remaining NCX function under inhibition may be a critical factor determining the inotropic and antiarrhythmic efficacy of SEA0400...
  78. Katanosaka Y, Iwata Y, Kobayashi Y, Shibasaki F, Wakabayashi S, Shigekawa M. Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes. J Biol Chem. 2005;280:5764-72 pubmed
    The cardiac Na(+)/Ca(2+) exchanger (NCX1) is the predominant mechanism for the extrusion of Ca(2+) from beating cardiomyocytes...
  79. Yamazaki D, Yamazaki T, Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. Pharmacol Ther. 2009;121:265-72 pubmed publisher
    ..This review focuses on cardiac Ca(2+) release by discussing pathological defects of mutant cardiomyocytes lacking ryanodine receptors, junctophilins, or TRIC channels. ..
  80. Andrikopoulos P, Baba A, Matsuda T, Djamgoz M, Yaqoob M, Eccles S. Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells. J Biol Chem. 2011;286:37919-31 pubmed publisher
    ..Knockdown of NCX1 (the main NCX isoform in HUVECs) by siRNA confirmed the pharmacological data...
  81. Magi S, Lariccia V, Castaldo P, Arcangeli S, Nasti A, Giordano A, et al. Physical and functional interaction of NCX1 and EAAC1 transporters leading to glutamate-enhanced ATP production in brain mitochondria. PLoS ONE. 2012;7:e34015 pubmed publisher
    ..colocalization, mutual activity dependency, physical interaction between EAAC1 and the sodium/calcium exchanger 1 (NCX1) both in neuronal and glial mitochondria, and that NCX1 is an essential modulator of this glutamate transporter...
  82. Shlosman I, Marinelli F, Faraldo Gómez J, Mindell J. The prokaryotic Na+/Ca2+ exchanger NCX_Mj transports Na+ and Ca2+ in a 3:1 stoichiometry. J Gen Physiol. 2018;150:51-65 pubmed publisher
  83. Wasserstrom J, Holt E, Sjaastad I, Lunde P, Odegaard A, Sejersted O. Altered E-C coupling in rat ventricular myocytes from failing hearts 6 wk after MI. Am J Physiol Heart Circ Physiol. 2000;279:H798-807 pubmed
    ..These results suggest significant changes in E-C coupling in the hypertrophy and failure that develop in response to extensive MI...
  84. Kohzuki H, Misawa H, Sakata S, Ohga Y, Takaki M. Sustained high O2 use for Ca2+ handling in rat ventricular slices under decreased free shortening after ryanodine. Am J Physiol Heart Circ Physiol. 2001;281:H566-72 pubmed
    ..Our results indicated that the VO2 increase following ryanodine treatment was derived from a net change of an increased external Ca2+ extrusion via Na+/Ca2+ exchanger and futile Ca2+ cycling via SR Ca2+-ATPase...
  85. Hwa J, Beckouche N, Huang L, Kram Y, Lindskog H, Wang R. Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow. Sci Rep. 2017;7:11965 pubmed publisher
    ..We examined the development of the dorsal aorta (DA) and the cardinal vein (CV) in Ncx1 -/- mutants, which lack blood flow due to a deficiency in a sodium calcium ion exchanger expressed ..
  86. Diaz Horta O, Kamagate A, Herchuelz A, Van Eylen F. Na/Ca exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells. Diabetes. 2002;51:1815-24 pubmed
    ..To test this hypothesis, the plasma membrane Na/Ca exchanger (NCX1.7 isoform) was stably overexpressed in insulin-secreting tumoral cells. NCX1...
  87. Tang B, Chow J, Dong T, Yang S, Lu D, Carethers J, et al. Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca(2+)/?-catenin signaling pathway. Cancer Lett. 2016;377:44-54 pubmed publisher
    ..pancreatic tumorigenesis in vitro and in vivo likely through the Ca(2+) entry mode of Na(+)/Ca(2+) exchanger 1 (NCX1) to induce Ca(2+) entry into PC cells...
  88. Sathish V, Delmotte P, Thompson M, Pabelick C, Sieck G, Prakash Y. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. PLoS ONE. 2011;6:e23662 pubmed publisher
    ..Western blot analysis showed significant expression of the NCX1 isoform, with increased NCX1 levels by both cytokines, effects blunted by inhibitors of nuclear factor NF-?B or ..
  89. Formisano L, Guida N, Valsecchi V, Pignataro G, Vinciguerra A, Pannaccione A, et al. NCX1 is a new rest target gene: role in cerebral ischemia. Neurobiol Dis. 2013;50:76-85 pubmed publisher
    The Na(+)-Ca(2+) exchanger 1 (NCX1), a bidirectional transporter that mediates the electrogenic exchange of one calcium ion for three sodium ions across the plasma membrane, is known to be involved in brain ischemia...
  90. Wanichawan P, Hafver T, Hodne K, Aronsen J, Lunde I, Dalhus B, et al. Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure. J Biol Chem. 2014;289:33984-98 pubmed publisher
    Cardiac sodium (Na(+))-calcium (Ca(2+)) exchanger 1 (NCX1) is central to the maintenance of normal Ca(2+) homeostasis and contraction. Studies indicate that the Ca(2+)-activated protease calpain cleaves NCX1...
  91. Zuo J, Zhen J, Wang F, Li Y, Zhou Z. Effect of Low-Intensity Pulsed Ultrasound on the Expression of Calcium Ion Transport-Related Proteins during Tertiary Dentin Formation. Ultrasound Med Biol. 2018;44:223-233 pubmed publisher
    ..Expression of calcium ion transport-related proteins (Cav1.2, NCX1 and TRPV1) was determined with immunohistochemical staining and imaging analysis...
  92. Mora M, Ferrero J, Romero L, Trénor B. Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure. PLoS ONE. 2017;12:e0187739 pubmed publisher
    ..The result of modifying the conductances of the remodeled proteins such as SERCA and NCX in heart failure has less impact on Ca2+ modulation. These differences should be taken into account when designing drug therapies. ..