SLC7A7

Summary

Gene Symbol: SLC7A7
Description: solute carrier family 7 member 7
Alias: LAT3, LPI, MOP-2, Y+LAT1, y+LAT-1, Y+L amino acid transporter 1, monocyte amino acid permease 2, solute carrier family 7 (amino acid transporter light chain, y+L system), member 7, solute carrier family 7 (cationic amino acid transporter, y+ system), member 7, y(+)L-type amino acid transporter 1
Species: human
Products:     SLC7A7

Top Publications

  1. Wu L, Liao P, He L, Ren W, Yin J, Duan J, et al. Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)- challenged growing pigs. BMC Vet Res. 2015;11:144 pubmed publisher
    ..Such effects includes weight loss, live injury and oxidation stress, and malabsorption of nutrients as a result of selective regulation of nutrient transporter genes such as EAAC-3, SGLT-1, PepT-1, CAT-1 and LAT-1. ..
  2. Cloots R, Sankaranarayanan S, Poynter M, Terwindt E, Van Dijk P, Lamers W, et al. Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice. BMC Pulm Med. 2017;17:158 pubmed publisher
    ..of OVA-induced AHR, but attenuated OVA-induced increases in expression of Arg2 and Nos2, Slc7a1, Slc7a2, and Slc7a7 (arginine transporters), Il4, Il5 and Il13 (TH2-type cytokines), Ccl2 and Ccl11 (chemokines), Ifng (T<..
  3. Miska K, Fetterer R, Wong E. mRNA expression of amino acid transporters, aminopeptidase, and the di- and tri-peptide transporter PepT1 in the intestine and liver of posthatch broiler chicks. Poult Sci. 2015;94:1323-32 pubmed publisher
    ..The liver should be capable of amino acid transport, but its capabilities may be more specific since the expression of several transporters in this organ is either absent or very low. ..
  4. Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy C, Straub A, et al. Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation. 2013;128:1770-80 pubmed publisher
    ..Treatment with l-arginine modestly lowers blood pressure of collectrin knockout mice. Collectrin is a consequential link between the transport of l-arginine and endothelial nitric oxide synthase uncoupling in hypertension. ..
  5. Otto A, Gan Schreier H, Zhu X, Tuma Kellner S, Staffer S, Ganzha A, et al. Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:662-676 pubmed publisher
    ..of 1-stearoyl lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), and lysophosphatidylinositol (LPI) as well as elevation of hepatic arachidonate, arachidonate-containing cholesterol esters and prostaglandin E2<..
  6. Minh T, Xuan T, Van T, Andriana Y, Viet T, Khanh T, et al. Phytochemical Analysis and Potential Biological Activities of Essential Oil from Rice Leaf. Molecules. 2019;24: pubmed publisher
    ..1 µg/mL), ABTS (IC50 = 198.3 µg/mL), FRAP (IC50 = 700.8 µg/mL) and β-carotene oxidation (LPI = 79%) revealed that EO possessed an excellent antioxidant activity...
  7. Arifin S, Falasca M. Lysophosphatidylinositol Signalling and Metabolic Diseases. Metabolites. 2016;6: pubmed publisher
    ..focus on the physiological and pathophysiological roles of the lysophospholipid mediator lysophosphatidylinositol (LPI) and its receptor G-protein coupled receptor 55 (GPR55) in metabolic diseases...
  8. Lv Q. Glucocorticoid combined with hyaluronic acid enhance glucocorticoid receptor activity through inhibiting p-38MAPK signal pathway activation in treating acute lung injury in rats. Eur Rev Med Pharmacol Sci. 2016;20:3920-3929 pubmed
    ..Moreover, lung water content, the ratio of wet and dry lung, and lung permeability index (LPI) was decreased after having treated the SD rats with a combination of dexamethasone and hyaluronic acid, and the ..
  9. Cahalan R, Bargary N, O Sullivan K. Pain and Injury in Elite Adolescent Irish Dancers: A Cross-Sectional Study. J Dance Med Sci. 2018;22:91-99 pubmed publisher
    ..Subjects were separated into a "more pain and injury (MPI)" group (N = 17) or "less pain and injury (LPI)" group (N = 20) based on their reported pain and injury history over the previous year...

More Information

Publications133 found, 100 shown here

  1. Su S, Miska K, Fetterer R, Jenkins M, Wong E. Expression of digestive enzymes and nutrient transporters in Eimeria-challenged broilers. Exp Parasitol. 2015;150:13-21 pubmed publisher
    ..The downregulation of nutrient transporters may also be a cellular response to reduced expression of the host defense protein LEAP2, which would diminish intracellular pools of nutrients and inhibit pathogen replication. ..
  2. Xuan T, Gangqiang G, Minh T, Quy T, Khanh T. An Overview of Chemical Profiles, Antioxidant and Antimicrobial Activities of Commercial Vegetable Edible Oils Marketed in Japan. Foods. 2018;7: pubmed publisher
    ..sesame, and rice bran showed markedly greater activity, whilst the percentage of lipid peroxidation inhibition (LPI%) in sunflower, canola, cotton, grape, flax, perilla, Inca inchi, perillartine, and rice bran were significantly ..
  3. Hosagasi N, Aydin M, Zenciroglu A, Ustun N, Beken S. Incidence of hypoglycemia in newborns at risk and an audit of the 2011 American academy of pediatrics guideline for hypoglycemia. Pediatr neonatol. 2018;59:368-374 pubmed publisher
    ..IDM), large-for-gestational-age (LGA) infants, small-for-gestational-age (SGA) infants, and late preterm infants (LPI)]. Of the 207 newborn infants, there were 12 cases in IDM group (5.7%), 79 cases in LGA group (38...
  4. Bjursell M, Ryberg E, Wu T, Greasley P, Bohlooly Y M, Hjorth S. Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation. PLoS ONE. 2016;11:e0167965 pubmed publisher
    ..We therefore generated male mice deficient in the gene coding for the cannabinoid/lysophosphatidylinositol (LPI) receptor Gpr55 and characterized them under normal dietary conditions as well as during high energy dense diet ..
  5. Palumbi R, Peschechera A, Margari M, Craig F, Cristella A, Petruzzelli M, et al. Neurodevelopmental and emotional-behavioral outcomes in late-preterm infants: an observational descriptive case study. BMC Pediatr. 2018;18:318 pubmed publisher
    ..The sample included 68 LPI (45 males and 23 females) aged from 2 to 16...
  6. Jain D, Hodonsky C, Schick U, Morrison J, Minnerath S, Brown L, et al. Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos. Hum Mol Genet. 2017;26:1193-1204 pubmed publisher
    ..We also identified several novel genetic loci involving or regulating hematopoietic transcription factors (CEBPE-SLC7A7, CEBPA and CRBN-TRNT1) associated with basophil count...
  7. Kremshofer J, Siwetz M, Berghold V, Lang I, Huppertz B, Gauster M. A role for GPR55 in human placental venous endothelial cells. Histochem Cell Biol. 2015;144:49-58 pubmed publisher
    ..Incubation with L-α-lysophosphatidylinositol (LPI), the specific and functional ligand for GPR55, at a concentration of 1 µM, significantly enhanced migration of ..
  8. Holland A, Hyatt H, Smuder A, Sollanek K, Morton A, Roberts M, et al. Influence of endurance exercise training on antioxidant enzymes, tight junction proteins, and inflammatory markers in the rat ileum. BMC Res Notes. 2015;8:514 pubmed publisher
    ..05) between SED and EXE. The ileum mRNA expressions of seven nutrient transporters (SLC5A8, SLC7A6, SLC6A19, SLC7A7, SLC27A2, SLC16A10, and SLC15A1) were not different between the two groups (p > 0.05)...
  9. Gonzales Siles L, Karlsson R, Kenny D, Karlsson A, Sjoling A. Proteomic analysis of enterotoxigenic Escherichia coli (ETEC) in neutral and alkaline conditions. BMC Microbiol. 2017;17:11 pubmed publisher
    ..surface proteome of ETEC exposed to alkaline conditions (pH 9) as compared to neutral conditions (pH 7) using a LPI Hexalane FlowCell combined with quantitative proteomics...
  10. Esterson Y, Flusberg M, Oh S, Mazzariol F, Rozenblit A, Chernyak V. Improved parenchymal liver enhancement with extended delay on Gd-EOB-DTPA-enhanced MRI in patients with parenchymal liver disease: associated clinical and imaging factors. Clin Radiol. 2015;70:723-9 pubmed publisher
    ..were used to calculate liver relative enhancement (LRE), liver-spleen index (LSI), and liver-portal vein index (LPI) for HBP-20 and HBP-30...
  11. Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, et al. Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes. Growth Horm IGF Res. 2018;42-43:66-73 pubmed publisher
    ..IGF-I also increased LAT1 mRNA level in another myocyte line, C2C12. Furthermore, IGF-I reduced LAT3 and LAT4 mRNA levels in both cell lines. GH reduced LAT3 and LAT4 mRNA levels in L6 cells...
  12. Kihara Y, Mizuno H, Chun J. Lysophospholipid receptors in drug discovery. Exp Cell Res. 2015;333:171-7 pubmed publisher
    ..LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-..
  13. Porter J, Cappellini M, Kattamis A, Viprakasit V, Musallam K, Zhu Z, et al. Iron overload across the spectrum of non-transfusion-dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions. Br J Haematol. 2017;176:288-299 pubmed publisher
    ..NTBI correlated with soluble transferrin receptor (sTfR), labile plasma iron (LPI) and nucleated red blood cells (NRBCs), with elevations generally confined to previously transfused patients...
  14. Waisbourd M, Pruzan N, Johnson D, Ugorets A, Crews J, Saaddine J, et al. The Philadelphia Glaucoma Detection and Treatment Project: Detection Rates and Initial Management. Ophthalmology. 2016;123:1667-1674 pubmed publisher
    ..If indicated, treatments included selective laser trabeculoplasty (SLT), laser peripheral iridotomy (LPI), or IOP-lowering medications...
  15. He Z, Wang Y, Zhang Y, Cheng H, Liu X. Stereoselective bioaccumulation of chiral PCB 91 in earthworm and its metabolomic and lipidomic responses. Environ Pollut. 2018;238:421-430 pubmed publisher
    ..six lysophosphatidylcholines (LPC), six lysophosphatidylethanolamine (LPE), eight lysophosphatidylinositol (LPI) and five lysophosphatidylserine (LPS) were also differentially expressed between exposure and control groups...
  16. Onishi M, Pecani K, Jones T, Pringle J, Cross F. F-actin homeostasis through transcriptional regulation and proteasome-mediated proteolysis. Proc Natl Acad Sci U S A. 2018;115:E6487-E6496 pubmed publisher
    ..of NAP1 reflects a broad transcriptional response, much of which depends on three proteins (LAT1, LAT2, and LAT3) identified previously as essential for NAP1 transcription...
  17. Huang X, Anderle P, Hostettler L, Baumann M, Surbek D, Ontsouka E, et al. Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia. BMC Genomics. 2018;19:173 pubmed publisher
    ..Identified by both methods, three overlapping targets, SLC7A7, SLC38A5 (amino acid transporters), and ABCA1 (cholesterol transporter), were further investigated at the protein ..
  18. Liu B, Song S, Ruz Maldonado I, Pingitore A, Huang G, Baker D, et al. GPR55-dependent stimulation of insulin secretion from isolated mouse and human islets of Langerhans. Diabetes Obes Metab. 2016;18:1263-1273 pubmed publisher
    ..In contrast, while the putative endogenous GPR55 agonist lysophosphatidylinositol (LPI, 5 µM) and the GPR55 antagonist cannabidiol (CBD, 1 µM) also elevated [Ca2+ ]i and ..
  19. Michno W, Wehrli P, Zetterberg H, Blennow K, Hanrieder J. GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology. Biochim Biophys Acta Proteins Proteom. 2019;1867:458-467 pubmed publisher
    ..AA) conjugated phosphatidylinositols (PI) and their corresponding degradation product, lyso-phosphatidylinositols (LPI) to the periphery of Aβ plaques was observed, indicating site specific macrophage activation and ganglioside ..
  20. Feral C, Tissot F, Tosello L, Fakhry N, Sebag F, Pacak K, et al. 18F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L. Eur J Nucl Med Mol Imaging. 2017;44:812-821 pubmed publisher
    ..The SDHx mutated samples exhibited a significant decrease in mRNA expression of LAT3 when compared to sporadic PPGLs (P?=?0.042). There was also a statistical trend toward decreased CD98hc (P?=?0...
  21. Elalfy M, Adly A, Awad H, Tarif Salam M, Berdoukas V, Tricta F. Safety and Efficacy of Early Start of Iron Chelation Therapy with Deferiprone in Young Children Newly Diagnosed with Transfusion-Dependent Thalassemia: A Randomized Controlled Trial. Am J Hematol. 2017;: pubmed publisher
    ..61 patients continued the study Levels of transferrin saturation (TSAT) and labile plasma iron (LPI) were measured as well...
  22. Wu L, Liao P, He L, Feng Z, Ren W, Yin J, et al. Dietary L-arginine supplementation protects weanling pigs from deoxynivalenol-induced toxicity. Toxins (Basel). 2015;7:1341-54 pubmed publisher
    ..05). Collectively, these results indicate that dietary supplementation with Arg exerts a protective role in pigs fed DON-contaminated diets. ..
  23. Gattermann N. Pathophysiological and clinical aspects of iron chelation therapy in MDS. Curr Pharm Des. 2012;18:3222-34 pubmed
    ..tools available for diagnosing iron overload, indicate the treatment options with currently available iron chelators, and discuss the measurement of labile plasma iron (LPI) as a tool to monitor the efficacy of iron chelation therapy.
  24. Liza Sharmini A, Ng G, Nor Sharina Y, Khairil Anuar M, Nik Azlan Z, Azhany Y. Clinical presentation, severity and progression of primary angle closure in malay and chinese patients. Med J Malaysia. 2014;69:245-51 pubmed
    ..Majority progressed within 1 year of diagnosis. Malays without laser peripheral iridotomy (LPI) have a 4 fold (95% CI 1.4, 10.9) risk of progression...
  25. Kargl J, Andersen L, Hasenöhrl C, Feuersinger D, Stančić A, Fauland A, et al. GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis. Br J Pharmacol. 2016;173:142-54 pubmed publisher
    ..HCT116 cells with the antagonists or after GPR55 siRNA knockdown while pretreatment with lysophosphatidylinositol (LPI), the endogenous ligand of GPR55, decreased integrity of the monolayers...
  26. Dosier L, Premkumar V, Zhu H, Akosman I, Wempe M, McMahon T. Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. Thromb Haemost. 2017;117:1402-1411 pubmed publisher
    The system L neutral amino acid transporter (LAT; LAT1, LAT2, LAT3, or LAT4) has multiple functions in human biology, including the cellular import of S-nitrosothiols (SNOs), biologically active derivatives of nitric oxide (NO)...
  27. Bouveau V, Haen T, Poupon J, Nich C. Outcomes after revision of metal on metal hip resurfacing to total arthroplasty using the direct anterior approach. Int Orthop. 2018;42:2543-2548 pubmed publisher
    ..003). Revision of failed MoM-HRA using the DAA resulted in an acceptable clinical outcome, no specific complication and no further surgery. A consistent decline in serum ion levels may be expected following HRA conversion to THA. ..
  28. Chan J, Choy B, Chan O, Li K. Early intraocular pressure change after peripheral iridotomy with ultralow fluence pattern scanning laser and Nd:YAG laser in primary angle-closure suspect: Kowloon East Pattern Scanning Laser Study Report No. 3. Graefes Arch Clin Exp Ophthalmol. 2018;256:363-369 pubmed publisher
    ..347). Sequential LPI using an ultralow fluence pattern scanning laser, followed by a Nd:YAG laser, is safe and efficacious, and produces ..
  29. Rezapour S, Najari S, Ghaemian N. The impacts of long-term intensive agriculture on the Vertisol properties in a calcareous region. Environ Monit Assess. 2015;187:247 pubmed publisher
    ..Land productivity index (LPI), evaluated based on parametric approach, suggested that Chromic Calcixererts and Typic Haploxererts highlighted a ..
  30. Zhao Q, Yu H, Ming Z, Hu H, Ren G, Liu H. The Bipartite Network Projection-Recommended Algorithm for Predicting Long Non-coding RNA-Protein Interactions. Mol Ther Nucleic Acids. 2018;13:464-471 pubmed publisher
    ..to predict the potential lncRNA-protein interactions with the bipartite network projection recommended algorithm (LPI-BNPRA)...
  31. Tognetto D, De Giacinto C, Cirigliano G. Suture of Symptomatic YAG Laser Peripheral Iridotomies Following Phakic Intraocular Lens Implantation. J Glaucoma. 2017;26:675-677 pubmed publisher
    ..Experiencing glare and photophobia is a rare side effect due to LPI. Suture of iridotomies using a modified Siepser slip-knot technique can be considered a safe and effective ..
  32. Usuki F, Fujimura M, Yamashita A. Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters. Sci Rep. 2017;7:12390 pubmed publisher
    ..upregulated the expression of methionine transporters that affect the cellular influx of MeHg, LAT1, LAT3, and SNAT2; and a membrane transporter that affects the efflux of MeHg, ABCC4, in MeHg-susceptible myogenic cells...
  33. Cherif H, Argaw A, Cécyre B, Bouchard A, Gagnon J, Javadi P, et al. Role of GPR55 during Axon Growth and Target Innervation. Eneuro. 2015;2: pubmed publisher
    ..When gpr55(+/+) neurons were treated with GPR55 agonists, lysophosphatidylinositol (LPI) and O-1602, we observed a chemo-attractive effect and an increase in GC size and filopodia number...
  34. Tudurí E, Lopez M, Dieguez C, Nadal A, Nogueiras R. GPR55 and the regulation of glucose homeostasis. Int J Biochem Cell Biol. 2017;88:204-207 pubmed publisher
    ..GPR55, the receptor for L-?-lysophosphatidylinositol (LPI) that has also affinity for various cannabinoid ligands, is distributed at the central and peripheral level and it ..
  35. Ogihara K, Naya Y, Sato R, Onda K, Ochiai H. Analysis of L-type amino acid transporter in canine hepatocellular carcinoma. J Vet Med Sci. 2015;77:527-34 pubmed publisher
    ..The deduced amino acid sequences of canine LAT2, LAT3 and LAT4 were well conserved in mammalians, exhibiting 89, 88 and 77% homology, respectively...
  36. Mellon D. Convergence of multimodal sensory input onto higher-level neurons of the crayfish olfactory pathway. J Neurophysiol. 2000;84:3043-55 pubmed
    ..observations suggest that a small cluster of neurons adjacent to the hemi-ellipsoid body are inhibitory to LPI activity...
  37. Li X, Liu Z, Ma H, Li Y, Zhao H, Che J, et al. Effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury in rats. Asian Pac J Trop Med. 2014;7:276-9 pubmed publisher
    ..Blood gas index, lung permeability index (LPI) change, lung tissue pathology change and lung water content were observed and compared between groups of rats at ..
  38. Rossi F, Casano A, Henke K, Richter K, Peri F. The SLC7A7 Transporter Identifies Microglial Precursors prior to Entry into the Brain. Cell Rep. 2015;11:1008-17 pubmed publisher
    ..Identification and cloning of a mutant that lacks microglia has shown that Slc7a7, a Leucine/Arginine transporter, defines a restricted macrophage sub-lineage and is necessary for brain ..
  39. Khan S, Qianli D, SongBo W, Zaman K, Zhang Y. Environmental logistics performance indicators affecting per capita income and sectoral growth: evidence from a panel of selected global ranked logistics countries. Environ Sci Pollut Res Int. 2017;24:1518-1531 pubmed publisher
    ..This study is exclusive as we utilized a number of LPI factors including logistics performance, logistics competence, and logistics infrastructure with mediation of ..
  40. Teto G, Kanmogne G, Torimiro J, Alemnji G, Nguemaim F, Takou D, et al. Lipid peroxidation and total cholesterol in HAART-naïve patients infected with circulating recombinant forms of human immunodeficiency virus type-1 in Cameroon. PLoS ONE. 2013;8:e65126 pubmed publisher
    ..TC), LDL cholesterol (LDLC), HDL cholesterol (HDLC), total antioxidant ability (TAA), lipid peroxidation indices (LPI), and malondialdehyde (MDA) in HIV negative persons and HIV positive HAART-naïve patients infected with HIV-1 ..
  41. Ang H, Koh J, Lee J, Pua Y. Development and preliminary validation of a leadership competency instrument for existing and emerging allied health professional leaders. BMC Health Serv Res. 2016;16:64 pubmed publisher
    ..and examines (i) its factor structure, (ii) its convergent validity with the Leadership Practices Inventory (LPI), and (iii) its discriminative validity in AHPs with different grades...
  42. Bang S, Joo C, Jun J. Reverse pupillary block after implantation of a scleral-sutured posterior chamber intraocular lens: a retrospective, open study. BMC Ophthalmol. 2017;17:35 pubmed publisher
    ..posterior chamber intraocular lens (PC IOL) implantation and biometric changes after laser peripheral iridotomy (LPI)...
  43. Zeng T, Chang S, Fan H, Liu Q. Design and Processing of a Novel Chaos-Based Stepped Frequency Synthesized Wideband Radar Signal. Sensors (Basel). 2018;18: pubmed publisher
    ..In addition, the single FSK modulation reduces the radar low probability of intercept (LPI) performance, for it cannot achieve a large time-bandwidth product...
  44. Vettorato E, Corletto F. Retrospective assessment of peripheral nerve block techniques used in cats undergoing hindlimb orthopaedic surgery. J Feline Med Surg. 2016;18:826-33 pubmed publisher
    ..Four combinations of PNBs were used: 34 lateral preiliac (LPI) approach to lumbar plexus (LP) associated with lumbar paravertebral approach to sciatic nerve (SN); 20 LPI-LP ..
  45. Bascom A, Ghosh S, Fairey A, Rourke K. Assessment of Wound Complications After Bulbar Urethroplasty: The Impact of a Lambda Perineal Incision. Urology. 2016;90:184-8 pubmed publisher
    ..diabetes, body mass index ≥ 35, smoking, and incision type (lambda perineal incision [LPI] vs. midline perineal incision [MPI])...
  46. Xu S, Tang K, Meng L, Tang Y. Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells. J Huazhong Univ Sci Technolog Med Sci. 2013;33:632-635 pubmed publisher
    ..Leucine is tightly linked to the mTOR pathway and can activate it, thereby stimulating cellular proliferation. LAT3 is a major transporter for leucine, and suppression of its expression can reduce cell proliferation...
  47. Tan J, Lim Y. Antioxidant and tyrosinase inhibition activity of the fertile fronds and rhizomes of three different Drynaria species. BMC Res Notes. 2015;8:468 pubmed publisher
    ..FRS), ferric reducing power (FRP), ferrous ion chelating (FIC) activity and lipid peroxidation inhibition (LPI). The tyrosinase inhibition activity of all three species was also reported. The fertile fronds of D...
  48. Noguchi A, Nakamura K, Murayama K, Yamamoto S, Komatsu H, Kizu R, et al. Clinical and genetic features of lysinuric protein intolerance in Japan. Pediatr Int. 2016;58:979-983 pubmed publisher
    ..by mutations in solute carrier family 7 amino acid transporter light chain, y+ L system, member 7 (SLC7A7)...
  49. Schraven S, Mlynski R, Dalhoff E, Heyd A, Wildenstein D, Rak K, et al. Coupling of an active middle-ear implant to the long process of the incus using an elastic clip attachment. Hear Res. 2016;340:179-184 pubmed publisher
    ..and a posterior tympanotomy, crimping the Floating Mass Transducer (FMT) to the long process of the incus (LPI) (standard crimped application)...
  50. Hu H, Zhu C, Ai H, Zhang L, Zhao J, Zhao Q, et al. LPI-ETSLP: lncRNA-protein interaction prediction using eigenvalue transformation-based semi-supervised link prediction. Mol Biosyst. 2017;13:1781-1787 pubmed publisher
    ..Here, we presented eigenvalue transformation-based semi-supervised link prediction (LPI-ETSLP) to uncover the relationship between lncRNAs and proteins...
  51. Alicandri Ciufelli M, Guarino P, Fabbri F, Cunsolo E, Presutti L, Anschuetz L. Middle ear microvascularization: an "in vivo" endoscopic anatomical study. Eur Arch Otorhinolaryngol. 2018;275:889-894 pubmed publisher
    ..an incudostapedial artery (ISA) was detected in 65% of cases with BFD going from the long process of the incus (LPI) toward the pyramidal eminence in the majority of cases...
  52. Nicolas C, Bednarek N, Vuiblet V, Boyer O, Brassier A, de Lonlay P, et al. Renal Involvement in a French Paediatric Cohort of Patients with Lysinuric Protein Intolerance. JIMD Rep. 2016;29:11-17 pubmed
    ..The SLC7A7 gene, mutated in LPI patients, encodes the light subunit (y+LAT1) of a member of the heterodimeric amino acid ..
  53. LoVasco L, Maher S, Thompson K, Stiller C. Perceived Leadership Practices in Year-One Students Enrolled in Professional Entry-Level Doctor of Physical Therapy Programs. J Allied Health. 2016;45:122-8 pubmed
    ..The Leadership Practices Inventory (LPI Self) developed by Kouzes and Posner was used to assess leadership practices of year-1 DPT students at six ..
  54. Ghilain V, Wiame E, Fomekong E, Vincent M, Dumitriu D, Nassogne M. Unusual association between lysinuric protein intolerance and moyamoya vasculopathy. Eur J Paediatr Neurol. 2016;20:777-81 pubmed publisher
    ..This diagnosis was confirmed by the detection of a mutation within the SLC7A7 gene upon molecular investigation...
  55. Anavi Goffer S, Irving A, Ross R. Modulation of l-?-lysophosphatidylinositol/GPR55 MAP kinase signalling by CB2 receptor agonists: identifying novel GPR55 inhibitors. J Basic Clin Physiol Pharmacol. 2016;27:303-10 pubmed publisher
    ..a lipid-sensing G protein-coupled receptor that is activated by the endogenous lipid l-?-lysophosphatidylinositol (LPI) and can be modulated by certain cannabinoid ligands...
  56. Chen S, Lv J, Fan S, Zhang H, Xie L, Xu L, et al. Laser peripheral iridotomy versus laser peripheral iridotomy plus laser peripheral iridoplasty in the treatment of multi-mechanism angle closure: study protocol for a randomized controlled trial. Trials. 2017;18:130 pubmed publisher
    ..Currently, opinion is that laser peripheral iridotomy (LPI) alone is not sufficient to prevent disease progression...
  57. Asaoka Y, Nagai Y, Namae M, Furutani Seiki M, Nishina H. SLC7 family transporters control the establishment of left-right asymmetry during organogenesis in medaka by activating mTOR signaling. Biochem Biophys Res Commun. 2016;474:146-153 pubmed publisher
    ..In this study, we identify the SLC7 amino acid transporters Slc7a7 and Slc7a8 as novel regulators of LR asymmetry development in the small fish medaka...
  58. Rana R, Ganguly R, Gupta A. Indexing method for assessment of pollution potential of leachate from non-engineered landfill sites and its effect on ground water quality. Environ Monit Assess. 2017;190:46 pubmed publisher
    ..distances from each of the landfill sites were collected and tested to determine the leachate pollution index (LPI) and the water quality index (WQI). The Leachate Pollution Index values of 26.1, 27 and 27...
  59. Lee K, Sung K, Kang S, Cho J, Kim D, Kook M. Residual anterior chamber angle closure in narrow-angle eyes following laser peripheral iridotomy: anterior segment optical coherence tomography quantitative study. Jpn J Ophthalmol. 2011;55:213-219 pubmed publisher
    To study quantitative changes in anterior chamber angle (ACA) after laser peripheral iridotomy (LPI) in narrow-angle eyes using anterior segment optical coherence tomography (AS-OCT)...
  60. Lothe A, Sinha A. Development of model for prediction of Leachate Pollution Index (LPI) in absence of leachate parameters. Waste Manag. 2017;63:327-336 pubmed publisher
    Leachate pollution index (LPI) is an environmental index which quantifies the pollution potential of leachate generated in landfill site...
  61. Habib A, Azize N, Yakob Y, Md Yunus Z, Wee T. Biochemical and molecular characteristics of Malaysian patients with lysinuric protein intolerance. Malays J Pathol. 2016;38:305-310 pubmed
    ..There were differences and similarities in the biochemical and molecular findings. Molecular analysis of SLC7A7 gene revealed a novel mutation c.235G>A; p.(Gly79Arg) in exon three in Patient 1 and a mutation c.1417C>T; p...
  62. Park H, Kim J, Shim S, Kim H, Bae J, Choi C, et al. Diurnal intraocular pressure changes in eyes affected with acute primary angle closure and fellow eyes after laser peripheral iridotomy. Jpn J Ophthalmol. 2015;59:318-24 pubmed publisher
    ..IOP) in eyes affected with unilateral acute primary angle closure (APAC) after laser peripheral iridotomy (LPI), and fellow eyes...
  63. Al Suleimani Y, Hiley C. Characterization of calcium signals provoked by lysophosphatidylinositol in human microvascular endothelial cells. Physiol Res. 2016;65:53-62 pubmed
    The lipid molecule, lysophosphatidylinositol (LPI), is hypothesised to form part of a novel lipid signalling system that involves the G protein-coupled receptor GPR55 and distinct intracellular signalling cascades in endothelial cells...
  64. Alhouayek M, Masquelier J, Muccioli G. Lysophosphatidylinositols, from Cell Membrane Constituents to GPR55 Ligands. Trends Pharmacol Sci. 2018;39:586-604 pubmed publisher
    ..As evidence supporting the importance of LPIs and/or GPR55 is continuously accumulating and because LPI levels are altered in a number of pathologies such as obesity and cancer, the coming years should bring new, ..
  65. Ang B, Nongpiur M, Aung T, Mizoguchi T, Ozaki M. Changes in Japanese eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study. Clin Exp Ophthalmol. 2016;44:159-65 pubmed publisher
    ..as assessed by anterior segment optical coherence tomography in Japanese subjects after laser peripheral iridotomy (LPI). This was a prospective observational study...
  66. Kair L, Colaizy T. Breastfeeding Continuation Among Late Preterm Infants: Barriers, Facilitators, and Any Association With NICU Admission?. Hosp Pediatr. 2016;6:261-8 pubmed publisher
    ..this study was to determine barriers to and facilitators of breastfeeding continuation among late preterm infants (LPI) and to compare the barriers faced by LPI admitted to the well nursery versus the NICU...
  67. Ono T, Iida M, Sakisaka T, Minami K, Miyata K. Effect of laser peripheral iridotomy using argon and neodymium-YAG lasers on corneal endothelial cell density: 7-year longitudinal evaluation. Jpn J Ophthalmol. 2018;62:216-220 pubmed publisher
    ..the changes in corneal endothelial cell density (ECD) over a 7-year period after laser peripheral iridotomy (LPI) using argon and neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers. Retrospective case series...
  68. Pitiot V, Hermann R, Tringali S, Dubreuil C, Truy E. Revision stapes surgery for lysis of the long process of the incus: comparing hydroxyapatite bone cement versus malleovestibulopexy and total ossicular replacement prosthesis. Eur Arch Otorhinolaryngol. 2016;273:2515-21 pubmed publisher
    ..Patients treated for revision stapes surgery from 2010 to 2014, where a lysis of the long process of the incus (LPI) was observed with the use of HAP bone cement, MV prosthesis, or a TORP were included in the study...
  69. Mauhin W, Habarou F, Gobin S, Servais A, Brassier A, Grisel C, et al. Update on Lysinuric Protein Intolerance, a Multi-faceted Disease Retrospective cohort analysis from birth to adulthood. Orphanet J Rare Dis. 2017;12:3 pubmed publisher
    Lysinuric protein intolerance (LPI) is a rare metabolic disease resulting from recessive-inherited mutations in the SLC7A7 gene encoding the cationic amino-acids transporter subunit y+LAT1...
  70. Arunbabu V, Indu K, Ramasamy E. Leachate pollution index as an effective tool in determining the phytotoxicity of municipal solid waste leachate. Waste Manag. 2017;68:329-336 pubmed publisher
    ..The crude leachate has an LPI value of 31.99 with high concentration of organic matter, ammonia and dissolved solids...
  71. Torrents D, Estevez R, Pineda M, Fernandez E, Lloberas J, Shi Y, et al. Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance. J Biol Chem. 1998;273:32437-45 pubmed
    ..2 (17cR approximately 374 kb from D14S1350), within the lysinuric protein intolerance (LPI) locus (Lauteala, T., Sistonen, P. , Savontaus, M. L., Mykkanen, J., Simell, J., Lukkarinen, M., Simmell, O...
  72. Cimbalistiene L, Lehnert W, Huoponen K, Kucinskas V. First reported case of lysinuric protein intolerance (LPI) in Lithuania, confirmed biochemically and by DNA analysis. J Appl Genet. 2007;48:277-80 pubmed
    ..Citrullinaemia was suspected. Subsequently the diagnosis of LPI was made on the basis of biochemical and clinical features. Molecular genetic testing revealed a mutation in the SLC7A7 gene, confirming the diagnosis.
  73. Toivonen M, Tringham M, Kurko J, Terho P, Simell O, Heiskanen K, et al. Interactions of y+LAT1 and 4F2hc in the y+l amino acid transporter complex: consequences of lysinuric protein intolerance-causing mutations. Gen Physiol Biophys. 2013;32:479-88 pubmed publisher
    Lysinuric protein intolerance (LPI) is an inherited aminoaciduria caused by recessive mutations in the SLC7A7 gene encoding y+L amino acid transporter 1 (y+LAT1), which combines with 4F2hc to generate an active transporter responsible for ..
  74. Theinert C, Wiedemann P, Unterlauft J. Laser peripheral iridotomy changes anterior chamber architecture. Eur J Ophthalmol. 2017;27:49-54 pubmed publisher
    ..angle closure (AAC) and primary angle closure suspects is balanced by a sufficient laser peripheral iridotomy (LPI)...
  75. Wang Y, Wang F, Zhang Y, Huang X, Hu D, Zheng W, et al. Polarization smoothing for single beam by a nematic liquid crystal scrambler. Appl Opt. 2017;56:8087-8091 pubmed publisher
    Polarization smoothing (PS) is a key approach to suppress laser plasma instabilities (LPI) in inertial confinement fusion (ICF) experiments...
  76. Kam J, Zepeda E, Ding L, Wen J. Resident-performed laser peripheral iridotomy in primary angle closure, primary angle closure suspects, and primary angle closure glaucoma. Clin Ophthalmol. 2017;11:1871-1876 pubmed publisher
    To investigate the power use and complication frequency of resident-performed laser peripheral iridotomy (LPI).
  77. Pfeiffer R, Rossier G, Spindler B, Meier C, Kuhn L, Verrey F. Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 1999;18:49-57 pubmed
  78. Borsani G, Bassi M, Sperandeo M, De Grandi A, Buoninconti A, Riboni M, et al. SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance. Nat Genet. 1999;21:297-301 pubmed
    ..We have identified two new transcripts (SLC7A8 and SLC7A7) homologous to amino acid transporters, highly expressed in kidney and mapping in the LPI critical region...
  79. Sperandeo M, Bassi M, Riboni M, Parenti G, Buoninconti A, Manzoni M, et al. Structure of the SLC7A7 gene and mutational analysis of patients affected by lysinuric protein intolerance. Am J Hum Genet. 2000;66:92-9 pubmed
    ..intolerance (LPI) is a rare autosomal recessive defect of cationic amino acid transport caused by mutations in the SLC7A7 gene...
  80. Puomila K, Simell O, Huoponen K, Mykkänen J. Two alternative promoters regulate the expression of lysinuric protein intolerance gene SLC7A7. Mol Genet Metab. 2007;90:298-306 pubmed
    The human SLC7A7 gene encodes y(+)L amino acid transporter-1 (y(+)LAT-1). Mutations in the SLC7A7 coding region cause a rare recessive disorder, lysinuric protein intolerance (LPI)...
  81. Barilli A, Rotoli B, Visigalli R, Bussolati O, Gazzola G, Dall Asta V. Arginine transport in human monocytic leukemia THP-1 cells during macrophage differentiation. J Leukoc Biol. 2011;90:293-303 pubmed publisher
    ..We show here that the induction of THP-1 monocyte differentiation by PMA markedly increases the expression of SLC7A7 mRNA and of y(+)LAT1 protein and consequently, the activity of system y(+)L-mediated arginine transport...
  82. Li X, Xu G, Zhai Z, Gao C, Yan H, Xi Q, et al. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget. 2016;7:30597-609 pubmed publisher
    ..and cell cycle cyclin-dependent kinases 1, 2 and 4, as well as the predicted CDX2 target genes SLC1A1, SLC5A1 and SLC7A7. In addition, luciferase reporter and chromatin immunoprecipitation assays revealed that CDX2 binds directly to ..
  83. Tudurí E, Imbernon M, Hernández Bautista R, Tojo M, Fernø J, Dieguez C, et al. GPR55: a new promising target for metabolism?. J Mol Endocrinol. 2017;58:R191-R202 pubmed publisher
    ..Lysophosphatidylinositol (LPI) is generally accepted as the endogenous ligand of GPR55...
  84. Mansoori T, Balakrishna N. Anterior Segment Morphology in Primary Angle Closure Glaucoma using Ultrasound Biomicroscopy. J Curr Glaucoma Pract. 2017;11:86-91 pubmed publisher
    ..the configuration of the anterior chamber angle quantitatively and study the morphological changes in the eye with ultrasound biomicroscopy (UBM) in primary angle closure glaucoma (PACG) patients after laser peripheral iridotomy (LPI).
  85. Zhou X, Guo X, Song Y, Zhu C, Zou W. The LPI/GPR55 axis enhances human breast cancer cell migration via HBXIP and p-MLC signaling. Acta Pharmacol Sin. 2018;39:459-471 pubmed publisher
    ..Moreover, the plasma levels of GPR55 endogenous agonist L-a-lysophosphatidylinositol (LPI) were significantly increased in breast cancer patients compared with healthy individuals...
  86. Lauteala T, Sistonen P, Savontaus M, Mykkänen J, Simell J, Lukkarinen M, et al. Lysinuric protein intolerance (LPI) gene maps to the long arm of chromosome 14. Am J Hum Genet. 1997;60:1479-86 pubmed
    Lysinuric protein intolerance (LPI) is an autosomal recessive disease characterized by defective transport of cationic amino acids and by hyperammonemia...
  87. Mykkänen J, Toivonen M, Kleemola M, Savontaus M, Simell O, Aula P, et al. Promoter analysis of the human SLC7A7 gene encoding y+L amino acid transporter-1 (y+LAT-1). Biochem Biophys Res Commun. 2003;301:855-61 pubmed
    The human SLC7A7 gene on chromosome 14q11...
  88. Araki N, Ishigami T, Ushio H, Minegishi S, Umemura M, Miyagi Y, et al. Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L. Biochem Biophys Res Commun. 2009;388:290-6 pubmed publisher
    ..NPC2 might regulate sodium reabsorption in the terminal nephron by interacting with ENaC-Nedd4L system. ..
  89. Lingerfelt M, Zhao P, Sharir H, Hurst D, Reggio P, Abood M. Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor. Biochemistry. 2017;56:473-486 pubmed publisher
    ..to identify residues that are key for the signaling of the GPR55 endogenous ligand, l-?-lysophosphatidylinositol (LPI), as well as the signaling of the GPR55 agonist, ML184 {CID 2440433, 3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]..
  90. Rukmini A, Najjar R, Atalay E, Sharma S, Lock J, Baskaran M, et al. Pupillary responses to light are not affected by narrow irido-corneal angles. Sci Rep. 2017;7:10190 pubmed publisher
    ..primary angle closure glaucoma and are prophylactically treated by performing laser peripheral iridotomy (LPI)...
  91. Shoji Y, Noguchi A, Shoji Y, Matsumori M, Takasago Y, Takayanagi M, et al. Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance. Hum Mutat. 2002;20:375-81 pubmed
    Two distinct human light subunits of the heteromeric amino acid transporter, y+LAT-1 coded by SLC7A7 and y+LAT-2 coded by SLC7A6, are both known to induce transport system y+L activity...