Gene Symbol: SLC7A6
Description: solute carrier family 7 member 6
Alias: LAT-2, LAT3, y+LAT-2, Y+L amino acid transporter 2, amino acid permease, cationic amino acid transporter, y+ system, solute carrier family 7 (amino acid transporter light chain, y+L system), member 6, solute carrier family 7 (cationic amino acid transporter, y+ system), member 6, y(+)L-type amino acid transporter 2, y+LAT2
Species: human
Products:     SLC7A6

Top Publications

  1. Wang J, Wu B, Lu K, Wei Q, Qian J, Chen Y, et al. The amino acid permease OsAAP5 regulates tiller number and grain yield in rice. Plant Physiol. 2019;: pubmed publisher
    ..Here, we identified an amino acid permease, OsAAP5, that regulates tiller number and grain yield in rice...
  2. Shewan A, McCann R, Lamb C, Stirrat L, Kioumourtzoglou D, Adamson I, et al. Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells. J Cell Sci. 2013;126:1576-82 pubmed publisher
    ..transporter GLUT4 in human fat and muscle cells and the nitrogen-regulated trafficking of the general amino acid permease Gap1 in the yeast Saccharomyces cerevisiae share several common features: Both Gap1 and GLUT4 are nutrient ..
  3. Hong K, Fu X, Dong S, Xiao D, Dong J. Modulating acetate ester and higher alcohol production in Saccharomyces cerevisiae through the cofactor engineering. J Ind Microbiol Biotechnol. 2019;: pubmed publisher
    ..Strains 12α-BAP2 and 12α+ATF1 where generated by deleting and overexpressing BAP2 (encoded branched-chain amino acid permease) and ATF1 (encoded alcohol acetyl transferases), respectively, in the parent 12α strains...
  4. Li Y, Wu F, Cai D, Zhan Y, Li J, Chen X, et al. [Enhanced production of bacitracin by knocking out of amino acid permease gene yhdG in Bacillus licheniformis DW2]. Sheng Wu Gong Cheng Xue Bao. 2018;34:916-927 pubmed publisher
    ..Then, the amino acid permease YhdG, which was identified as the BCAA permease, was deleted and overexpressed in DW2, respectively...
  5. Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, et al. Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes. Growth Horm IGF Res. 2018;42-43:66-73 pubmed publisher
    ..IGF-I also increased LAT1 mRNA level in another myocyte line, C2C12. Furthermore, IGF-I reduced LAT3 and LAT4 mRNA levels in both cell lines. GH reduced LAT3 and LAT4 mRNA levels in L6 cells...
  6. Chung J, Bauer D, Ghamari A, Nizzi C, Deck K, Kingsley P, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015;8:ra34 pubmed publisher
    ..As red blood cells matured, expression of the amino acid transporter gene Lat3 increased, which increased NEAA import...
  7. Ghaddar K, Merhi A, Saliba E, Krammer E, Prévost M, André B. Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases. Mol Cell Biol. 2014;34:4447-63 pubmed publisher
    ..We report here that two amino acid transporters of Saccharomyces cerevisiae, the general amino acid permease (Gap1) and the arginine-specific permease (Can1), undergo ubiquitin-dependent downregulation in response to ..
  8. Muller K, Zampieri R, Aoki J, Muxel S, Nerland A, Floeter Winter L. Amino acid permease 3 (aap3) coding sequence as a target for Leishmania identification and diagnosis of leishmaniases using high resolution melting analysis. Parasit Vectors. 2018;11:421 pubmed publisher
    ..The amino acid permease 3 (aap3) gene is an exclusive target for trypanosomatids and is conserved among Leishmania spp...
  9. Ogihara K, Naya Y, Sato R, Onda K, Ochiai H. Analysis of L-type amino acid transporter in canine hepatocellular carcinoma. J Vet Med Sci. 2015;77:527-34 pubmed publisher
    ..The leucine transport activity of canine HCCs was 0.628 ± 0.018 nmol/mg protein/min. The inhibitor of LAT 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) reduced 90% of the activity at 1 mM...

More Information


  1. Zbinden I, Rutz E, Jacobson J, Magerkurth O. Tibial bowing in children - what is normal? A radiographic study. Eur Radiol. 2015;25:3459-71 pubmed publisher
    ..0-98.0); angle-AC lat was 76-102 (89.5-86.5); depth of curve ap was 0-11 % (8-3.5) and lat 2-13 %, (8.5-3.5)...
  2. Song J, Jiang L, Jameson P. Expression patterns of Brassica napus genes implicate IPT, CKX, sucrose transporter, cell wall invertase, and amino acid permease gene family members in leaf, flower, silique, and seed development. J Exp Bot. 2015;66:5067-82 pubmed publisher
    ..BnCKX1 to BnCKX7), cell wall invertase (BnCWINV1 to BnCWINV6), sugar transporter (BnSUT1 to BnSUT6) and amino acid permease (BnAAP1 to BnAAP8) were identified. As B...
  3. Huseinovic A, Dekker S, Boogaard B, Vermeulen N, Kooter J, Vos J. Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion. Amino Acids. 2018;50:1377-1390 pubmed publisher
    ..APAP and tyrosine, and a similarity with drugs like rapamycin and quinine, which induce degradation of the amino acid permease Tat2...
  4. Ehrnstorfer I, Geertsma E, Pardon E, Steyaert J, Dutzler R. Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport. Nat Struct Mol Biol. 2014;21:990-6 pubmed publisher
    ..ScaDMT shows a familiar architecture that was previously identified in the amino acid permease LeuT...
  5. Zhang L, Garneau M, Majumdar R, Grant J, Tegeder M. Improvement of pea biomass and seed productivity by simultaneous increase of phloem and embryo loading with amino acids. Plant J. 2015;81:134-46 pubmed publisher
    ..Additional copies of the pea amino acid permease PsAAP1 were introduced into the pea genome and expression of the transporter was targeted to the sieve ..
  6. Wang J, Lu Z, Tokheim C, Miller S, Xing Y. Species-specific exon loss in human transcriptomes. Mol Biol Evol. 2015;32:481-94 pubmed publisher
    ..In SLC7A6, a gene encoding an amino acid transporter, luciferase reporter assays suggested that both a human-specific exon ..
  7. Perchlik M, Tegeder M. Leaf Amino Acid Supply Affects Photosynthetic and Plant Nitrogen Use Efficiency under Nitrogen Stress. Plant Physiol. 2018;178:174-188 pubmed publisher
    ..Arabidopsis plants with a knockout of AAP2, encoding an amino acid permease involved in xylem-to-phloem transfer of root-derived amino acids, were grown in low-, moderate-, and high-..
  8. Wijayanti I, Watanabe D, Oshiro S, Takagi H. Isolation and functional analysis of yeast ubiquitin ligase Rsp5 variants that alleviate the toxicity of human α-synuclein. J Biochem. 2015;157:251-60 pubmed publisher
    ..from our previously identified RSP5(T357A) mutation, which increases ubiquitination of the general amino acid permease Gap1...
  9. Tian X, Meng X, Wang L, Song Y, Zhang D, Ji Y, et al. Molecular cloning, mRNA expression and tissue distribution analysis of Slc7a11 gene in alpaca (Lama paco) skins associated with different coat colors. Gene. 2015;555:88-94 pubmed publisher
    ..analysis showed that alpaca xCT contains 12 transmembrane regions consistent with the highly conserved amino acid permease (AA_permease_2) domain similar to other vertebrates...
  10. Cheng G, Karunakaran R, East A, Munoz Azcarate O, Poole P. Glutathione affects the transport activity of Rhizobium leguminosarum 3841 and is essential for efficient nodulation. FEMS Microbiol Lett. 2017;364: pubmed publisher
    ..branched amino acid transporter, this was not the case for all uptake transport systems, for example, the amino acid permease. This suggests GSH alters activity and/or assembly of transport systems by an unknown mechanism...
  11. Onishi M, Pecani K, Jones T, Pringle J, Cross F. F-actin homeostasis through transcriptional regulation and proteasome-mediated proteolysis. Proc Natl Acad Sci U S A. 2018;115:E6487-E6496 pubmed publisher
    ..of NAP1 reflects a broad transcriptional response, much of which depends on three proteins (LAT1, LAT2, and LAT3) identified previously as essential for NAP1 transcription...
  12. Zou C, Wang P, Liang S, Han S, Zheng S, Lin Y. Deletion of the GCW13 gene derepresses Gap1-dependent uptake of amino acids in Pichia pastoris grown on methanol as the sole carbon source. Biochem Biophys Res Commun. 2018;501:226-231 pubmed publisher
    ..involved in the biosynthesis of amino acids were down-regulated, whereas GAP1, which encodes a general amino acid permease, was significantly up-regulated...
  13. Estrada A, Muruganandam G, Prescianotto Baschong C, Spang A. The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes. Biol Open. 2015;4:792-802 pubmed publisher
    ..significantly altered plasma membrane localization of the tryptophan transporter Tat2, the general amino acid permease Gap1 and the v-SNARE Snc1, in a Δglo3 Δerg3 strain those proteins accumulated in internal endosomal ..
  14. Onishi M, Pringle J, Cross F. Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas. Genetics. 2016;202:977-96 pubmed publisher
    ..Thirty-nine LatB-sensitive mutants fell into four genes (NAP1 and LAT1-LAT3) in which we identified the causative mutations using a novel combinatorial pool-sequencing strategy...
  15. Chen X, Wang Z, Guo X, Liu S, He X. Regulation of general amino acid permeases Gap1p, GATA transcription factors Gln3p and Gat1p on 2-phenylethanol biosynthesis via Ehrlich pathway. J Biotechnol. 2017;242:83-91 pubmed publisher
    ..General amino acid permease Gap1p is response of aromatic amino acids transportation, and GATA transcription factors Gln3p and Gat1p ..
  16. Pérez Delos Santos F, Riego Ruiz L. Gln3 is a main regulator of nitrogen assimilation in Candida glabrata. Microbiology. 2016;162:1490-9 pubmed publisher
    ..upregulate genes involved in nutrient acquisition, including nitrogen transporters such as the general amino acid permease Gap1, the dicarboxylic amino acid permease Dip5, the basic amino acid permease Can1 and the ammonium ..
  17. Mochizuki T, Kimata Y, Uemura S, Abe F. Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae. FEMS Yeast Res. 2015;15:fov044 pubmed publisher
    ..In this study, we used domain replacement with general amino acid permease Gap1 to show that Tat2 chimeric proteins were dysfunctional when TMD10 or TMD11 was replaced...
  18. Liefbroer A, Poortman A, Seltzer J. Why do intimate partners live apart? Evidence on LAT relationships across Europe. Demogr Res. 2015;32:251-286 pubmed
    ..In Western Europe, LAT unions are mainly an alternative for persons who have been married before or had children in a prior relationship. ..
  19. Xu P, Gao J, Cao Z, Chee P, Guo Q, Xu Z, et al. Fine mapping and candidate gene analysis of qFL-chr1, a fiber length QTL in cotton. Theor Appl Genet. 2017;130:1309-1319 pubmed publisher
    ..of these genes, GOBAR07705 (encoding 1-aminocyclopropane-1-carboxylate synthase) and GOBAR25992 (encoding amino acid permease), were positively correlated with fiber length in a small F2 population, supporting these genes ..
  20. Yin C, Downey S, Klages Mundt N, Ramachandran S, Chen X, Szabo L, et al. Identification of promising host-induced silencing targets among genes preferentially transcribed in haustoria of Puccinia. BMC Genomics. 2015;16:579 pubmed publisher
    ..sugar metabolism, a protein involved in thiazol biosynthesis, a protein involved in auxin biosynthesis, an amino acid permease, two hypothetical proteins with no conserved domains, a predicted small secreted protein and another ..
  21. Holland A, Hyatt H, Smuder A, Sollanek K, Morton A, Roberts M, et al. Influence of endurance exercise training on antioxidant enzymes, tight junction proteins, and inflammatory markers in the rat ileum. BMC Res Notes. 2015;8:514 pubmed publisher
    ..05) between SED and EXE. The ileum mRNA expressions of seven nutrient transporters (SLC5A8, SLC7A6, SLC6A19, SLC7A7, SLC27A2, SLC16A10, and SLC15A1) were not different between the two groups (p > 0.05)...
  22. Rijckaert J, Pardon B, Verryken K, Van Ham L, van Loon G, Deprez P. Motor evoked potentials in standing and recumbent calves induced by magnetic stimulation at the foramen magnum. Vet J. 2016;216:178-82 pubmed publisher
    ..1?±?2.1?mV) in the pelvic limbs. In conclusion, mMEPs in limb muscles can be evoked in calves by stimulation at the level of the foramen magnum. mMEPs are more difficult to obtain in lateral recumbency than in standing calves. ..
  23. Ai C, McCarthy S, Eckrich V, Rudrappa D, Qiu G, Blum P. Increased acid resistance of the archaeon, Metallosphaera sedula by adaptive laboratory evolution. J Ind Microbiol Biotechnol. 2016;43:1455-65 pubmed publisher identified two mutations in SARC-M1 including a nonsynonymous mutation in Msed_0408 (an amino acid permease) and a deletion in pseudogene Msed_1517...
  24. Feral C, Tissot F, Tosello L, Fakhry N, Sebag F, Pacak K, et al. 18F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L. Eur J Nucl Med Mol Imaging. 2017;44:812-821 pubmed publisher
    ..The SDHx mutated samples exhibited a significant decrease in mRNA expression of LAT3 when compared to sporadic PPGLs (P?=?0.042). There was also a statistical trend toward decreased CD98hc (P?=?0...
  25. Zielińska M, Milewski K, Skowrońska M, Gajos A, Ziemińska E, Beręsewicz A, et al. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter. J Neurochem. 2015;135:1272-81 pubmed publisher
    ..described effects of ammonia were abrogated by pre-treatment of astrocytes with either siRNA silencing of the Slc7a6 gene coding for y(+)LAT2 protein, or antibody to y(+)LAT2, indicating their strict coupling to y(+)LAT2 activity...
  26. Villers J, Savocco J, Szopinska A, Degand H, Nootens S, Morsomme P. Study of the Plasma Membrane Proteome Dynamics Reveals Novel Targets of the Nitrogen Regulation in Yeast. Mol Cell Proteomics. 2017;16:1652-1668 pubmed publisher regulation has only been studied for very few proteins among which the general amino acid permease Gap1...
  27. Žárský V, Doležal P. Evolution of the Tim17 protein family. Biol Direct. 2016;11:54 pubmed, our analyses do not support the affiliation of the protein family and the component of bacterial amino acid permease. Thus, it is likely that Tim17 protein family is exclusive to eukaryotes...
  28. Cameron T, Cooke I, Faou P, Toet H, Piedrafita D, Young N, et al. A novel ex vivo immunoproteomic approach characterising Fasciola hepatica tegumental antigens identified using immune antibody from resistant sheep. Int J Parasitol. 2017;47:555-567 pubmed publisher
    ..Three of the membrane proteins are transporters including a multidrug resistance protein, an amino acid permease and a glucose transporter...
  29. Binek A, Rembierz Knoll A, Polańska J, Jarosz Chobot P. Reasons for the discontinuation of therapy of personal insulin pump in children with type 1 diabetes. Pediatr Endocrinol Diabetes Metab. 2016;21:65-9 pubmed publisher
    ..3±3.33 vs. 14.69 ±2.82 (p=0.04). Wnioski. Ocena stanu emocjonalnego pacjenta oraz odpowiednia edukacja są ważne w chwili rozpoczynania terapii CSII oraz w jej trakcie. ..
  30. Ohshima Y, Kaira K, Yamaguchi A, Oriuchi N, Tominaga H, Nagamori S, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016;107:1499-1505 pubmed publisher
    ..Thus, our results suggest that LAT1 inhibition could be a promising molecular target for the esophageal cancer therapy. ..
  31. Jameson P, Dhandapani P, Novak O, Song J. Cytokinins and Expression of SWEET, SUT, CWINV and AAP Genes Increase as Pea Seeds Germinate. Int J Mol Sci. 2016;17: pubmed
    ..To determine if the sucrose transporter (SUT), amino acid permease (AAP), Sugar Will Eventually be Exported Transporter (SWEET), cell wall invertase (CWINV
  32. Belitsky B, Brinsmade S, Sonenshein A. Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB. PLoS Genet. 2015;11:e1005600 pubmed publisher
    ..The increase in BraB expression only at intermediate activities of CodY may facilitate the uptake of BCAA when they are not in excess but prevent unneeded BraB synthesis when other BCAA transporters are active. ..
  33. Hill S, Donegan R, Nguyen E, Desai T, Lieberman R. Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies. PLoS ONE. 2015;10:e0130888 pubmed publisher
    ..norvegicus glio-OLF and M. musculus latrophilin-3 (lat3-OLF) by others...
  34. Watanabe D, Murai H, Tanahashi R, Nakamura K, Sasaki T, Takagi H. Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2. Biochem Biophys Res Commun. 2015;463:76-81 pubmed publisher
    ..To elucidate the role of each WW domain in endocytosis of the general amino acid permease Gap1 via interaction with the arrestin-like adaptor proteins Bul1 and Bul2 (Bul1/2), we investigated the ..
  35. Chai C, Wang Y, Valliyodan B, Nguyen H. Comprehensive Analysis of the Soybean (Glycine max) GmLAX Auxin Transporter Gene Family. Front Plant Sci. 2016;7:282 pubmed publisher
    ..The AUXIN RESISTENT 1/LIKE AUX1 (AUX/LAX) auxin influx carriers belong to the amino acid permease family of proton-driven transporters and function in the uptake of indole-3-acetic acid (IAA)...
  36. Zhang Y, Wang P, Xia H, Zhao C, Hou L, Li C, et al. Comparative transcriptome analysis of basal and zygote-located tip regions of peanut ovaries provides insight into the mechanism of light regulation in peanut embryo and pod development. BMC Genomics. 2016;17:606 pubmed publisher
    ..protein, cellulose synthase, homeobox-leucine zipper (HD-Zip) protein family genes, amino acid permease, and seed growth and embryo morphogenesis regulators (DA1, TCP3, and YABBY)...
  37. Gaździńska A, Baran P, Skibniewski F, Truszczyński O, Gaździński S, Wyleżoł M. [The prevalence of overweight and obesity vs. the level of physical activity of aviation military academy students]. Med Pr. 2015;66:653-60 pubmed publisher pr. 2015;66(5):653–660. ..
  38. Liu P, Ge M, Hu J, Li X, Che L, Sun K, et al. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis. Hepatology. 2017;66:167-181 pubmed publisher
    ..up-regulation of multiple amino acid transporters, including solute carrier family 1 member A5 (SLC1A5) and SLC7A6, leading to robust uptake of amino acids, including glutamine, into c-Myc tumor cells...
  39. Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, et al. Amino acid transporter LAT3 is required for podocyte development and function. J Am Soc Nephrol. 2009;20:1586-96 pubmed publisher
    b>LAT3 is a Na+-independent neutral l-amino acid transporter recently isolated from a human hepatocellular carcinoma cell line...
  40. Yamamoto S, Kimura T, Tachiki T, Anzai N, Sakurai T, Ushimaru M. The involvement of L-type amino acid transporters in theanine transport. Biosci Biotechnol Biochem. 2012;76:2230-5 pubmed
    ..Taken together, our results indicate that L-theanine is transported mostly via the system L transport pathway and its isoforms. ..
  41. Rong Mullins X, Ravishankar A, McNeal K, Lonergan Z, Biega A, Creamer J, et al. Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae. PLoS ONE. 2017;12:e0187522 pubmed publisher
    ..within Aro1, instead, it was caused by genetic variation in an ABC multiple drug transporter, Pdr5, and an amino acid permease, Dip5...
  42. Aoki J, Muxel S, Zampieri R, Acuña S, Fernandes J, Vanderlinde R, et al. L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis. PLoS Negl Trop Dis. 2017;11:e0006025 pubmed publisher
    ..L-arginine is not synthesized by the parasite, so its uptake occurs through the amino acid permease 3 (AAP3). AAP3 is codified by two copies genes (5.1 and 4...
  43. Xu S, Tang K, Meng L, Tang Y. Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells. J Huazhong Univ Sci Technolog Med Sci. 2013;33:632-635 pubmed publisher
    ..Leucine is tightly linked to the mTOR pathway and can activate it, thereby stimulating cellular proliferation. LAT3 is a major transporter for leucine, and suppression of its expression can reduce cell proliferation...
  44. Santiago J, Tegeder M. Implications of nitrogen phloem loading for carbon metabolism and transport during Arabidopsis development. J Integr Plant Biol. 2017;59:409-421 pubmed publisher
    ..Specifically, Arabidopsis aap8 (AMINO ACID PERMEASE 8) mutant lines were analyzed to resolve the consequences of reduced amino acid phloem loading for source ..
  45. Wang Q, Bailey C, Ng C, Tiffen J, Thoeng A, Minhas V, et al. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Res. 2011;71:7525-36 pubmed publisher
    L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids...
  46. Bröer A, Wagner C, Lang F, Broer S. The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine. Biochem J. 2000;349 Pt 3:787-95 pubmed
    ..These results indicated that arginine has the highest affinity for the intracellular binding site and that arginine release may be the main physiological function of this transporter. ..
  47. Usuki F, Fujimura M, Yamashita A. Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters. Sci Rep. 2017;7:12390 pubmed publisher
    ..upregulated the expression of methionine transporters that affect the cellular influx of MeHg, LAT1, LAT3, and SNAT2; and a membrane transporter that affects the efflux of MeHg, ABCC4, in MeHg-susceptible myogenic cells...
  48. Kuwahara H, Yuki M, Izawa K, Ohkuma M, Hongoh Y. Genome of 'Ca. Desulfovibrio trichonymphae', an H2-oxidizing bacterium in a tripartite symbiotic system within a protist cell in the termite gut. ISME J. 2017;11:766-776 pubmed publisher
    ..Endomicrobium trichonymphae'. An amino acid permease gene has apparently been transferred between the ancestors of these two symbionts; a lateral gene transfer ..
  49. Pfeiffer R, Rossier G, Spindler B, Meier C, Kuhn L, Verrey F. Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 1999;18:49-57 pubmed
    ..This transporter consists of a novel amino acid permease-related protein (LAT1 or AmAT-L-lc) which for surface expression and function requires formation of ..
  50. Dall Asta V, Bussolati O, Sala R, Rotoli B, Sebastio G, Sperandeo M, et al. Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects. Am J Physiol Cell Physiol. 2000;279:C1829-37 pubmed
    ..Both cell types express SLC7A1 (CAT1) and SLC7A2 (CAT2B and CAT2A) as well as SLC7A6 (y+LAT2) and SLC7A7 (y+LAT1)...
  51. Xu D, Hemler M. Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics. 2005;4:1061-71 pubmed
    ..This approach should also be applicable to many other types of transmembrane proteins besides those associated with CD98hc and CD147. ..
  52. Torrents D, Estevez R, Pineda M, Fernandez E, Lloberas J, Shi Y, et al. Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance. J Biol Chem. 1998;273:32437-45 pubmed
    ..The pattern of expression of human y+LAT-1, its co-expressed transport activity with 4F2hc, and its chromosomal location within the LPI locus, suggest y+LAT-1 as a candidate gene for LPI. ..
  53. Wang Q, Tiffen J, Bailey C, Lehman M, Ritchie W, Fazli L, et al. Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development. J Natl Cancer Inst. 2013;105:1463-73 pubmed publisher
    ..LAT1 and LAT3 are overexpressed at different stages of prostate cancer, and they are responsible for increasing nutrients and ..
  54. Milewski K, Bogacińska Karaś M, Fresko I, Hilgier W, Jaźwiec R, Albrecht J, et al. Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y?LAT2 Carrier-Mediated Loss. Int J Mol Sci. 2017;18: pubmed publisher
    ..concentration in both cell types, and the effect in astrocytes was substantially attenuated by silencing of the Slc7a6 gene...
  55. Balthasar C, Stangl H, Widhalm R, Granitzer S, Hengstschläger M, Gundacker C. Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter. Int J Mol Sci. 2017;18: pubmed publisher
    ..The findings together can explain why mercury in contrast to other heavy metals such as lead or cadmium is efficiently transported to fetal blood. ..
  56. Dosier L, Premkumar V, Zhu H, Akosman I, Wempe M, McMahon T. Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. Thromb Haemost. 2017;117:1402-1411 pubmed publisher
    The system L neutral amino acid transporter (LAT; LAT1, LAT2, LAT3, or LAT4) has multiple functions in human biology, including the cellular import of S-nitrosothiols (SNOs), biologically active derivatives of nitric oxide (NO)...
  57. Schmidt A, Hall M, Koller A. Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol Cell Biol. 1994;14:6597-606 pubmed
    ..Here we report that TAT1 and TAT2 encode novel members of the yeast amino acid permease family composed of integral membrane proteins that share 30 to 40% identity...