SLC7A5

Summary

Gene Symbol: SLC7A5
Description: solute carrier family 7 member 5
Alias: 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, large neutral amino acids transporter small subunit 1, 4F2 light chain, CD98 light chain, L-type amino acid transporter 1, integral membrane protein E16, sodium-independent neutral amino acid transporter LAT1, solute carrier family 7 (amino acid transporter light chain, L system), member 5, solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Species: human
Products:     SLC7A5

Top Publications

  1. Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, et al. Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung. Pathol Res Pract. 2008;204:553-61 pubmed publisher
    Amino acid transport systems play an important role in cellular proliferation. L-type amino acid transporter 1 (LAT1) has been associated with tumor growth, and is highly expressed in the established tumor cell lines and primary human ..
  2. Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, et al. CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases. Ann Surg Oncol. 2009;16:3473-81 pubmed publisher
    ..of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement...
  3. Hayashi K, Jutabha P, Endou H, Anzai N. c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells. Oncol Rep. 2012;28:862-6 pubmed publisher
    ..L-type amino acid transporter 1 (LAT1) incorporates large neutral amino acids, most of which are also categorized as essential amino acids, ..
  4. Nawashiro H, Otani N, Shinomiya N, Fukui S, Ooigawa H, Shima K, et al. L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Int J Cancer. 2006;119:484-92 pubmed
    ..LAT1 has been identified as a light chain of the CD98 heterodimer from C6 glioma cells...
  5. Ichinoe M, Mikami T, Yoshida T, Igawa I, Tsuruta T, Nakada N, et al. High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions. Pathol Int. 2011;61:281-9 pubmed publisher
    ..In the present study, L-type amino-acid transporter 1 (LAT1) immunoreactive expression was investigated in gastric carcinomas, in comparison with gastric adenomas and non-..
  6. Furuya M, Horiguchi J, Nakajima H, Kanai Y, Oyama T. Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis. Cancer Sci. 2012;103:382-9 pubmed publisher
    ..Out of 129 patients, LAT1 was positive in 56 patients (43.4%), and CD98 was positive in 41 patients (31.8%)...
  7. Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, et al. Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma. Lung Cancer. 2009;66:120-6 pubmed publisher
    The purpose of this study was to evaluate the prognostic value of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in patients with stage I pulmonary adenocarcinoma...
  8. Imai H, Kaira K, Oriuchi N, Yanagitani N, Sunaga N, Ishizuka T, et al. L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer. Histopathology. 2009;54:804-13 pubmed publisher
    To evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) in patients with stage I non-small cell lung cancer (NSCLC)...
  9. Matsuo H, Tsukada S, Nakata T, Chairoungdua A, Kim D, Cha S, et al. Expression of a system L neutral amino acid transporter at the blood-brain barrier. Neuroreport. 2000;11:3507-11 pubmed
    ..Using immunohistochemical analyses, a system L transporter LAT1 was shown to be expressed in the brain capillary endothelial cells in rats...

More Information

Publications111 found, 100 shown here

  1. Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, et al. Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer. Br J Cancer. 2008;98:742-8 pubmed publisher
    The clinical significance of L-type amino acid transporter 1 (LAT1) expression remains unclear, whereas many experimental studies have demonstrated that LAT1 is associated with the proliferation of cancer cells...
  2. Sakata T, Ferdous G, Tsuruta T, Satoh T, Baba S, Muto T, et al. L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol Int. 2009;59:7-18 pubmed publisher
    ..biomarkers for high-grade malignancy, the relationship between immunohistochemical L-type amino-acid transporter 1 (LAT1) expression of biopsy samples, determined with the newly developed monoclonal antibody against human LAT1, and ..
  3. Wang Q, Bailey C, Ng C, Tiffen J, Thoeng A, Minhas V, et al. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Res. 2011;71:7525-36 pubmed publisher
    L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids...
  4. Kim D, Kanai Y, Choi H, Tangtrongsup S, Chairoungdua A, Babu E, et al. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim Biophys Acta. 2002;1565:112-21 pubmed
    ..In malignant tumors, a system L transporter L-type amino acid transporter 1 (LAT1) is up-regulated to support tumor cell growth...
  5. Nakanishi K, Ogata S, Matsuo H, Kanai Y, Endou H, Hiroi S, et al. Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract. Virchows Arch. 2007;451:681-90 pubmed
    L-type amino acid transporter 1 (LAT1), a neutral amino acid transporter, requires covalent association with the heavy chain of 4F2 cell surface antigen (4F2hc) for its functional form...
  6. Yanagisawa N, Ichinoe M, Mikami T, Nakada N, Hana K, Koizumi W, et al. High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas. J Clin Pathol. 2012;65:1019-23 pubmed publisher
    Molecular target therapy against L-type amino acid transporter 1 (LAT1) is unique and expected to be developed soon. LAT1 expression was investigated in pancreatic cancer as a prognostic predictor...
  7. Nakada N, Mikami T, Hana K, Ichinoe M, Yanagisawa N, Yoshida T, et al. Unique and selective expression of L-amino acid transporter 1 in human tissue as well as being an aspect of oncofetal protein. Histol Histopathol. 2014;29:217-27 pubmed publisher
    Dysregulated expression of L-type amino acid transporter 1 (LAT1), which transports large neutral amino acids, is a characteristic of various human cancers and possibly offers a molecular target for chemotherapy...
  8. Nakanishi K, Matsuo H, Kanai Y, Endou H, Hiroi S, Tominaga S, et al. LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Virchows Arch. 2006;448:142-50 pubmed
    No previous study has investigated neutral large amino acid transporter type 1 (LAT1) in normal lung cells, or in atypical adenomatous hyperplasia(s) (AAH) and nonmucinous bronchioloalveolar carcinoma(s) (NMBAC) of the lung...
  9. Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, et al. L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma. Anticancer Res. 2011;31:4075-82 pubmed
    L-Type amino acid transporter 1 (LAT1) is known to be highly expressed in various human neoplasms. However, little is known about how LAT1 is expressed in malignant pleural mesothelioma (MPM)...
  10. Yanagida O, Kanai Y, Chairoungdua A, Kim D, Segawa H, Nii T, et al. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta. 2001;1514:291-302 pubmed
    ..site has been predicted in its extracellular loop, consistent with the property of the classical 4F2 light chain. The properties of the hLAT1/h4F2hc complex would support the roles of this transporter in providing cells ..
  11. Kobayashi K, Ohnishi A, Promsuk J, Shimizu S, Kanai Y, Shiokawa Y, et al. Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. Neurosurgery. 2008;62:493-503; discussion 503-4 pubmed publisher
    To study the expression and function of L-type amino acid transporter 1 (LAT1), a major catalytic subunit of system L that is responsible for the transport of large neutral amino acids, including most essential amino acids, in concert ..
  12. Dong X, Zhou Z, Wang L, Saremi B, Helmbrecht A, Wang Z, et al. Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci. 2018;101:5502-5514 pubmed publisher
    ..it resulted in the lowest phosphorylation of Akt and eEF2 and mRNA abundance of CSN2 and various AA transporters (SLC7A5, SLC36A1, SLC38A2, SLC38A9, SLC43A1)...
  13. Batistel F, Alharthi A, Wang L, Parys C, Pan Y, Cardoso F, et al. Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight. J Nutr. 2017;147:1640-1647 pubmed publisher
    ..of genes involved in neutral amino acid transport [solute carrier (SLC) family members SLC3A2, SLC7A5, SLC38A1, and SLC38A10], glucose transport [SLC2A1, SLC2A3, and SLC2A4], ..
  14. He B, Zhang N, Jia Y, Sun Q, Zhao R. Glucocorticoid receptor-mediated insulin-like growth factor-I transcriptional regulation in BeWo trophoblast cells before and after syncytialisation. Steroids. 2016;115:26-33 pubmed publisher
    ..05) cell proliferation in cytotrophoblasts and down-regulated amino acid transporter SLC7A5 in syncytiotrophoblasts...
  15. Simner C, Novakovic B, Lillycrop K, Bell C, Harvey N, Cooper C, et al. DNA methylation of amino acid transporter genes in the human placenta. Placenta. 2017;60:64-73 pubmed publisher
    ..The transporter genes SLC1A2, SLC1A3, SLC1A4, SLC7A5, SLC7A11 and SLC7A10 had significant changes in enhancer DNA methylation across gestation, as well as gene ..
  16. Lee K, Kang Y. l-Citrulline restores nitric oxide level and cellular uptake at the brain capillary endothelial cell line (TR-BBB cells) with glutamate cytotoxicity. Microvasc Res. 2018;120:29-35 pubmed publisher
    ..l-Citrulline treatment increased cell viability, [14C] l-citrulline uptake, and the mRNA levels of LAT1 and eNOS in TR-BBB cells treated with glutamate. However, iNOS mRNA expression was inhibited by l-citrulline...
  17. Kaufman J, Kassube K, Almeida R, Rius A. Short communication: High incubation temperature in bovine mammary epithelial cells reduced the activity of the mTOR signaling pathway. J Dairy Sci. 2018;101:7480-7486 pubmed publisher
    ..In experiment 1, gene expression of AA transporters (SLC1A1, SLC1A5, SLC3A2, SLC7A1, SLC7A5, and SLC36A1) were evaluated, and changes of ≥2 fold were deemed significantly different...
  18. Ding L, Chen L, Wang M, Zhang J, Loor J, Zhou G, et al. Inhibition of arginase via jugular infusion of N?-hydroxy-nor-l-arginine inhibits casein synthesis in lactating dairy cows. J Dairy Sci. 2018;101:3514-3523 pubmed publisher
    ..not change compared with the nor-NOHA group, but the milk protein yield, the expression of some Arg transporters (SLC7A5 and SLC7A8), and milk yield increased...
  19. Roberts L, Black D, Raman C, Woodford K, Zhou M, Haggerty J, et al. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience. 2008;155:423-38 pubmed publisher
    ..cassette (Abc) g2, multidrug resistance protein (Mrp) 4 (Abcc4), glucose transporter 1 (Glut1) (Slc2a1), Lat1 (Slc7a5), and monocarboxylate transporter-1 (Mct1) (Slc16a1) on the luminal surface of rat cerebral microvessels by both ..
  20. Dong X, Zhou Z, Saremi B, Helmbrecht A, Wang Z, Loor J. Varying the ratio of Lys:Met while maintaining the ratios of Thr:Phe, Lys:Thr, Lys:His, and Lys:Val alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci. 2018;101:1708-1718 pubmed publisher
    ..5. However, compared with IPAA, mRNA expression of ?-casein and AA transporters (SLC7A5, SLC36A1, SLC38A2, SLC38A9, and SLC43A1) and mTOR phosphorylation were lower in response to LM2.5 and LM2.0...
  21. Javed K, Fairweather S. Amino acid transporters in the regulation of insulin secretion and signalling. Biochem Soc Trans. 2019;: pubmed publisher
    ..We also survey the roles SNAT (SLC38) family and LAT1 (SLC7A5) amino acid transporters play in the regulation of and by insulin in numerous affective tissues...
  22. Popławski P, Wisniewski J, Rijntjes E, Richards K, Rybicka B, Köhrle J, et al. Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system. PLoS ONE. 2017;12:e0190179 pubmed publisher
    ..Furthermore, DIO1 re-expression enhanced concentrations of two subunits of thyroid hormone transporter (SLC7A5, SLC3A2), enzymes of key pathways of cellular energy metabolism (e.g...
  23. Loftus R, Assmann N, Kedia Mehta N, O Brien K, Garcia A, Gillespie C, et al. Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice. Nat Commun. 2018;9:2341 pubmed publisher
    ..We identify SLC7A5 as the predominant system L-amino acid transporter in activated NK cells...
  24. Hayashi K, Ouchi M, Endou H, Anzai N. HOXB9 acts as a negative regulator of activated human T cells in response to amino acid deficiency. Immunol Cell Biol. 2016;94:612-7 pubmed publisher
    ..by amino acid deprivation as well as functional inhibition of L-type amino acid transporter 1 (also known as SLC7A5) via activating transcription factor 4 in activated T cells...
  25. Kambayashi T, Okumura M, Baker R, Hsu C, Baumgart T, Zhang W, et al. Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. Mol Cell Biol. 2010;30:4188-96 pubmed publisher
    ..The formation of a multimolecular proximal signaling complex nucleated by the adaptor molecules SLP-76 and LAT1 is required for activation through this receptor...
  26. Chan S, Martin Santos A, Loubière L, Gonzalez A, Stieger B, Logan A, et al. The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation. J Physiol. 2011;589:2827-45 pubmed publisher
    ..reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar...
  27. Lifantseva N, Koneeva T, Voronova S, Zakharova L, Melnikova V. The inhibition of dopamine synthesis in fetuses changes the pattern of T-lymphocyte maturation in the thymus of adult rats. Dokl Biochem Biophys. 2016;470:342-344 pubmed
    ..type D1, D3, D5, but not type D2, was detected in the thymus of rats starting from day 16 of embryonic development (E16)...
  28. Ring B, Seitz R, Beck R, Shasteen W, Soltermann A, Arbogast S, et al. A novel five-antibody immunohistochemical test for subclassification of lung carcinoma. Mod Pathol. 2009;22:1032-43 pubmed publisher
    ..Five of these antibodies, targeting the proteins TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6, were combined into one test using a weighted algorithm trained to discriminate adenocarcinoma ..
  29. Park Y, Sohn B, Johnson R, Kang M, Kim S, Shim J, et al. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology. 2016;63:159-72 pubmed publisher
    ..of the amino acid transporters solute carrier family 38 member 1 (SLC38A1) and solute carrier family 7 member 5 (SLC7A5)...
  30. Bhat N, Adams C, Chen Y, Bieber M, Teng N. Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34-Encoded Natural IgM Antibodies. J Immunol. 2015;195:5178-88 pubmed publisher
    ..ionization mass spectrometry, we identify the metabolic activation related protein complex of CD147-CD98 as a major carrier of poly-N-acetyl-lactosamine (SC-PNAL) on human pre-B cell line Nalm-6...
  31. Ouyang H, Chen X, Wang Z, Yu J, Jia X, Li Z, et al. Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens. DNA Res. 2017;: pubmed publisher
    ..leg muscles of female Xinghua (XH) chicken at three developmental time points 11 embryo age (E11), 16 embryo age (E16) and 1?day post hatch (P1) were performed RNA sequencing...
  32. Yu M, Mu C, Yang Y, Zhang C, Su Y, Huang Z, et al. Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets. Amino Acids. 2017;49:1587-1599 pubmed publisher
    ..05) the mRNA expression levels for jejunal AAs transporters (CAT1, EAAC1, ASCT2, y+LAT1), peptide transporters (PepT1), and Na+-K+-ATPase (ATP1A1), and ileal AA transporters (ASCT2, ..
  33. Maiti P, Paladugu L, Dunbar G. Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer's disease. BMC Neurosci. 2018;19:7 pubmed publisher
    ..and permeability of Cur and SLCP were made in cultured N2a cells and in primary hippocampal neurons derived from E16 pups of 5xFAD mice...
  34. Takeuchi K, Ogata S, Nakanishi K, Ozeki Y, Hiroi S, Tominaga S, et al. LAT1 expression in non-small-cell lung carcinomas: analyses by semiquantitative reverse transcription-PCR (237 cases) and immunohistochemistry (295 cases). Lung Cancer. 2010;68:58-65 pubmed publisher
    ..Little is known about the role of l-amino acid transporter 1 (LAT1), a member of the system l-amino acid transporter family, in non-small-cell lung carcinomas (NSCLCs)...
  35. Gaccioli F, Aye I, Roos S, Lager S, Ramirez V, Kanai Y, et al. Expression and functional characterisation of System L amino acid transporters in the human term placenta. Reprod Biol Endocrinol. 2015;13:57 pubmed publisher
    System L transporters LAT1 (SLC7A5) and LAT2 (SLC7A8) mediate the uptake of large, neutral amino acids in the human placenta. Many System L substrates are essential amino acids, thus representing crucial nutrients for the growing fetus...
  36. Le Vee M, Jouan E, Lecureur V, Fardel O. Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells. Toxicol Appl Pharmacol. 2016;290:74-85 pubmed publisher
    ..Factors that contribute to LAT1/CD98hc overexpression in lung cells remain however to be determined, but the implication of atmospheric pollution ..
  37. Duan X, Lin Y, Lv H, Yang Y, Jiao H, Hou X. Methionine Induces LAT1 Expression in Dairy Cow Mammary Gland by Activating the mTORC1 Signaling Pathway. DNA Cell Biol. 2017;36:1126-1133 pubmed publisher
    ..L-type amino acid transporter 1 (LAT1), which induces the transport of neutral amino acids, is highly expressed in lactating mammary gland...
  38. Adler W, Platt M, Mehlhorn A, Haight J, Currier T, Etchegaray M, et al. Position of neocortical neurons transfected at different gestational ages with shRNA targeted against candidate dyslexia susceptibility genes. PLoS ONE. 2013;8:e65179 pubmed publisher
    ..5, e15.5, or e16.5)...
  39. Zheng L, Zhang W, Zhou Y, Li F, Wei H, Peng J. Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1. Int J Mol Sci. 2016;17: pubmed
    ..Plasma membrane transceptor L amino acid transporter 1 (LAT1)-4F2hc has dual transporter-receptor function that can sense extracellular AA availability upstream of mTORC1...
  40. Kim Y, Andrés Salazar Hernández M, Herrema H, Delibasi T, Park S. The role of BRD7 in embryo development and glucose metabolism. J Cell Mol Med. 2016;20:1561-70 pubmed publisher
    ..Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.
  41. Canup B, Song H, Le Ngo V, Meng X, Denning T, Garg P, et al. CD98 siRNA-loaded nanoparticles decrease hepatic steatosis in mice. Dig Liver Dis. 2017;49:188-196 pubmed publisher
    ..Here, we investigated whether a reduction of CD98 expression mediated by CD98 siRNA-loaded nanoparticles (NPs) could attenuate liver disease markers in a mouse model ..
  42. Serrano Mujica L, Bertolin K, Bridi A, Glanzner W, Rissi V, de Camargo F, et al. The impact of postnatal leuprolide acetate treatment on reproductive characteristics in a rodent model of polycystic ovary syndrome. Mol Cell Endocrinol. 2017;442:125-133 pubmed publisher
    ..LA), was given as a single depot injection before 48 h of life to Wistar female rats allotted to prenatal (E16-18) and postnatal androgenization (day 5 of life) by the use of testosterone propionate, looking for reproductive ..
  43. Galluccio M, Pingitore P, Scalise M, Indiveri C. Cloning, large scale over-expression in E. coli and purification of the components of the human LAT 1 (SLC7A5) amino acid transporter. Protein J. 2013;32:442-8 pubmed publisher
    ..The yield of the over-expressed protein after purification was 3.5 mg/L (cell culture). The human CD98 cDNA amplified from Imagene plasmid was cloned in pGEX-4T1...
  44. Liu Y, Kong X, Li F, Tan B, Li Y, Duan Y, et al. Co-dependence of genotype and dietary protein intake to affect expression on amino acid/peptide transporters in porcine skeletal muscle. Amino Acids. 2016;48:75-90 pubmed publisher
    ..Bama mini-pigs had higher (P < 0.05) mRNA levels for LAT1, SNAT2, and EAAC1, but a lower (P < 0.05) mRNA level for PepT1, compared with Landrace pigs...
  45. Yang Z, Li D, Feng S, Sui X, Chen Z, Zhang L. Spatial and temporal expression of Sox9 during murine incisor development. J Mol Histol. 2017;48:321-327 pubmed publisher
    ..5 to postnatal (PN) day 10. At E13.5 and E14.5, Sox9 was strongly expressed in the dental epithelium. At E16.5, Sox9 started to be detected in the mesenchymal cells within the dental pulp, especially the dental pulp cells ..
  46. Wu L, Liu C, Jiang M, Jiang Y, Wang Q, Lu Z, et al. Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an "eye open at birth" phenotype. Genet Mol Res. 2016;15: pubmed publisher
    ..open at birth phenotype, abnormal round cell shape from tightened F-actin bundles in leading edge keratinocytes at E16.5, and gradual corneal opacity with neovessels...
  47. Li S, Loor J, Liu H, Liu L, Hosseini A, Zhao W, et al. Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants. J Dairy Sci. 2017;100:6676-6688 pubmed publisher
    ..In MAC-T cells, the OPAA upregulated the mRNA expression of SLC1A5 and SLC7A5 but downregulated the expression of IRS1, AKT3, EEF1A1, and EEF2 compared with the control...
  48. Wu L, Liao P, He L, Ren W, Yin J, Duan J, et al. Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)- challenged growing pigs. BMC Vet Res. 2015;11:144 pubmed publisher
    ..Such effects includes weight loss, live injury and oxidation stress, and malabsorption of nutrients as a result of selective regulation of nutrient transporter genes such as EAAC-3, SGLT-1, PepT-1, CAT-1 and LAT-1. ..
  49. Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, et al. Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [(18)F]FAMT positron emission tomography. J Pharmacol Sci. 2016;130:101-9 pubmed publisher
    ..The tumor specific uptake of FAMT is due to its high-selectivity to cancer-type amino acid transporter LAT1 among amino acid transporters...
  50. Beals J, Sukiennik R, Nallabelli J, Emmons R, van Vliet S, Young J, et al. Anabolic sensitivity of postprandial muscle protein synthesis to the ingestion of a protein-dense food is reduced in overweight and obese young adults. Am J Clin Nutr. 2016;104:1014-1022 pubmed
    ..signaling, amino acid transporters [large neutral and small neutral amino acid transporters (LAT1, SNAT2) and CD98], and myofibrillar protein synthesis...
  51. Yang G, Jiang B, Cai W, Liu S, Zhao S. Hyaluronan and hyaluronan synthases expression and localization in embryonic mouse molars. J Mol Histol. 2016;47:413-20 pubmed publisher
    ..The first mandibular embryonic mouse molars were examined by immunohistochemistry at E11.5, E13.5, E14.5, E16.5, and E18.5. PCR and western blot analyses were performed on RNA and proteins samples from E13.5 to E18...
  52. Guru Vishnu P, Bhattacharya T, Kumar P, Chaterjee R, Ravi Kumar G, Paswan C, et al. Expression Profiling of Activin type IIB Receptor During Ontogeny in Broiler and Indigenous Chicken. Anim Biotechnol. 2017;28:26-36 pubmed publisher
    ..28 to 7.14 folds during embryonic and post embryonic age, respectively. ACTRIIB exhibited its peak on E7, E11, and E16 during embryonic age, which coincides with the formation of primary and secondary muscle fibers in both lines...
  53. Zur A, Chien H, Augustyn E, Flint A, Heeren N, Finke K, et al. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Bioorg Med Chem Lett. 2016;26:5000-5006 pubmed publisher
    Large neutral amino acid transporter 1 (LAT1) is a solute carrier protein located primarily in the blood-brain barrier (BBB) that offers the potential to deliver drugs to the brain...
  54. Reinisch A, Majeti R. Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML. Cancer Cell. 2016;30:662-664 pubmed publisher
    In this issue of Cancer Cell, Bajaj and colleagues report that CD98, a heterodimeric protein highly expressed in acute myeloid leukemia (AML) and largely dispensable for basal hematopoiesis, plays an important role in facilitating ..
  55. Liu W, Chen H, Wong N, Haynes W, Baker C, Wang X. Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. Cancer Lett. 2017;394:65-75 pubmed publisher
    ..or CRISPR knockout of miR-126, we have identified SERPINE1 as a miR-126-5p target regulating cell motility, and SLC7A5 as a miR-126-3p target regulating the mTOR/HIF pathway...
  56. Uchida Y, Toyohara T, Ohtsuki S, Moriyama Y, Abe T, Terasaki T. Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney. J Pharm Sci. 2016;105:1011-1016 pubmed publisher
    ..The expression levels of abca2, abca4, abca5, abca12, abcb4, mrp5, abcc9, abcg1, abcg5, lat1, ntcp, pgt, oatp2b1, oatp1b2, oatp3a1, and oct3 were under the limit of quantification in both fractions...
  57. Richardson A, Lobo E, Delic N, Myerscough M, Lyons J, Wakefield D, et al. Keratin-14-Positive Precursor Cells Spawn a Population of Migratory Corneal Epithelia that Maintain Tissue Mass throughout Life. Stem Cell Reports. 2017;9:1081-1096 pubmed publisher
    ..We show that keratin-14 (K14+)-expressing progenitors are defined and widely distributed across the E16.5 cornea, after which they undergo cycles of proliferation and dispersal prior to eyelid opening...
  58. Hayashi K, Anzai N. Role of LAT1 in the promotion of amino acid incorporation in activated T cells. Crit Rev Immunol. 2014;34:467-79 pubmed
    ..This review describes the functional advantages of using special nutrient transporters in activated T cells and discusses the mechanisms of responses to nutrient starvation in T cells. ..
  59. Huttunen K, Huttunen J, Aufderhaar I, Gynther M, Denny W, Spicer J. L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors. Int J Pharm. 2016;498:205-16 pubmed publisher
    ..designing and synthesizing four prodrugs of perforin inhibitors that could utilize l-type amino acid transporter (LAT1), since activated immune cells are known to over-express LAT1...
  60. Yadav V, Varum F, Bravo R, Furrer E, Bojic D, Basit A. Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets. Transl Res. 2016;176:38-68 pubmed publisher
    ..These include various gut proteins (CXCL-10, GATA-3, NKG2D, CD98, microRNAs), immune cells recruited to the gut (mast cells, eosinophils, toll-like receptors 2, 4), dysregulated ..
  61. Chan A, Li S, Lee A, Leung J, Yip A, Bird J, et al. Activation of state-regulating neurochemical systems in newborn and embryonic chicks. Neuroscience. 2016;339:219-234 pubmed publisher
    ..Unexpectedly, a strong activation was seen at E16 in H/O neurons. The highest activation of Ch-LDT/PT (also S-active) and MCH neurons was seen at E20...
  62. Ding K, Tan S, Huang X, Wang X, Li X, Fan R, et al. GSE1 predicts poor survival outcome in gastric cancer patients by SLC7A5 enhancement of tumor growth and metastasis. J Biol Chem. 2018;293:3949-3964 pubmed publisher
    ..Furthermore, GSE1 positively regulated the downstream gene SLC7A5 (also known as LAT-1), which was scanned and verified from mRNA sequencing...
  63. Honjo H, Kaira K, Miyazaki T, Yokobori T, Kanai Y, Nagamori S, et al. Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma. J Surg Oncol. 2016;113:381-9 pubmed publisher
    ..Immunohistochemical analysis was performed for LAT1, ASCT2, CD98, Ki-67, and micro-vessel density (MVD), as determined by CD34 expression...
  64. Storey B, Fugere C, Lesieur Brooks A, Vaslet C, Thompson N. Adenoviral modulation of the tumor-associated system L amino acid transporter, LAT1, alters amino acid transport, cell growth and 4F2/CD98 expressionwith cell-type specific effects in cultured hepatic cells. Int J Cancer. 2005;117:387-97 pubmed
    ..The extent to which these may to contribute to the growth autonomy associated with cancer is not clear. LAT1 is a major L-type amino acid transporter over-expressed in a variety of cancer types and a light chain component of ..
  65. Maglott D, Durkin A, Lane S, Callen D, Feldblyum T, Nierman W. The gene for membrane protein E16 (D16S469E) maps to human chromosome 16q24.3 and is expressed in human brain, thymus, and retina. Genomics. 1994;23:303-4 pubmed
  66. Sequeira Lopez M, Pentz E, Robert B, Abrahamson D, Gomez R. Embryonic origin and lineage of juxtaglomerular cells. Am J Physiol Renal Physiol. 2001;281:F345-56 pubmed
    ..At E16 renin cells acquired smooth muscle but not endothelial markers, indicating that these cells are not related to the ..
  67. Simmons Willis T, Koh A, Clarkson T, Ballatori N. Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2. Biochem J. 2002;367:239-46 pubmed
    ..studies were carried out in Xenopus laevis oocytes expressing two of the major L-type carriers in humans, LAT1-4F2 heavy chain (4F2hc) and LAT2-4F2hc...
  68. Kühne A, Kaiser R, Schirmer M, Heider U, Muhlke S, Niere W, et al. Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan. Pharmacogenet Genomics. 2007;17:505-17 pubmed
    ..pharmacokinetic variability may be determined by genetic polymorphisms in the L-type amino acid transporters LAT1 (SLC7A5) and LAT2 (SLC7A8)...
  69. Theodosakis N, Micevic G, Sharma R, Baras A, Lazova R, Bosenberg M, et al. Integrative discovery of CD98 as a melanoma biomarker. Pigment Cell Melanoma Res. 2016;29:385-7 pubmed publisher
  70. Choi D, Kim D, Kanai Y, Wempe M, Endou H, Kim J. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017;21:599-607 pubmed publisher
    Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased growth and proliferation...
  71. Ohgimoto S, Tabata N, Suga S, Nishio M, Ohta H, Tsurudome M, et al. Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules. J Immunol. 1995;155:3585-92 pubmed
    ..Eleven of fifteen N-terminal amino acids of FRP-1 were the same as the amino acid sequence of 4F2/CD98 heavy chain...
  72. Napolitano L, Scalise M, Galluccio M, Pochini L, Albanese L, Indiveri C. LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter. Int J Biochem Cell Biol. 2015;67:25-33 pubmed publisher
    LAT1 (SLC7A5) and CD98 (SLC3A2) constitute a heterodimeric transmembrane protein complex that catalyzes amino acid transport. Whether one or both subunits are competent for transport is still unclear...
  73. Yanagisawa N, Satoh T, Hana K, Ichinoe M, Nakada N, Endou H, et al. L-amino acid transporter 1 may be a prognostic marker for local progression of prostatic cancer under expectant management. Cancer Biomark. 2015;15:365-74 pubmed publisher
    ..To assess the correlation between overexpression of LAT1 and local progression (LP) in prostatic carcinoma (PC) patients under expectant management (EM)...
  74. Yothaisong S, Dokduang H, Anzai N, Hayashi K, Namwat N, Yongvanit P, et al. Inhibition of l-type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment. Tumour Biol. 2017;39:1010428317694545 pubmed publisher
    ..Our previous study reported that l-type amino acid transporter-1 and its co-functional protein CD98 were highly expressed and implicated in cholangiocarcinoma progression and carcinogenesis...
  75. Wang J, Chen X, Su L, Li P, Cai Q, Liu B, et al. MicroRNA-126 inhibits cell proliferation in gastric cancer by targeting LAT-1. Biomed Pharmacother. 2015;72:66-73 pubmed publisher
    ..This might provide us likely potential biomarkers and targets for GC prevention, diagnosis and therapeutic treatment. ..
  76. Barollo S, Bertazza L, Watutantrige Fernando S, Censi S, Cavedon E, Galuppini F, et al. Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors. PLoS ONE. 2016;11:e0156044 pubmed publisher
    ..neutral amino acid biochemically resembling endogenous L-DOPA and taken up by the L-type amino acid transporters (LAT1 and LAT2). This study was conducted to examine the expression of the LAT system in PHEO and MTC...
  77. Vincentz J, Toolan K, Zhang W, Firulli A. Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function. PLoS Genet. 2017;13:e1006922 pubmed publisher
    ..Once Hand1-linage cells are removed from the LV, and Hand1 expression is switched off, embryonic hearts recover by E16.5...
  78. Ito M, Takebayashi S, Okumura K, Ohkubo T, Nishio M, Kawano M, et al. Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1. Int J Biochem Cell Biol. 2002;34:1152-63 pubmed
    The human system L-amino acid transporter1 (hLAT1) is one of the CD98 light chains and its gene has been mapped to chromosome 16q24...
  79. Yanagisawa N, Hana K, Nakada N, Ichinoe M, Koizumi W, Endou H, et al. High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas. Cancer Med. 2014;3:1246-55 pubmed publisher
    ..To investigate whether LAT1 expression influence the outcomes of patients with bile duct cancer, the expression of LAT1, LAT2, CD98, and Ki-67 ..
  80. Papin Michault C, Bonnetaud C, Dufour M, Almairac F, Coutts M, Patouraux S, et al. Study of LAT1 Expression in Brain Metastases: Towards a Better Understanding of the Results of Positron Emission Tomography Using Amino Acid Tracers. PLoS ONE. 2016;11:e0157139 pubmed publisher
    ..The amino acid transporter LAT1 and its cofactor CD98, which are involved in AA uptake, have never been investigated in BM...
  81. Sarmiento L, Frisk G, Anagandula M, Hodik M, Barchetta I, Netanyah E, et al. Echovirus 6 Infects Human Exocrine and Endocrine Pancreatic Cells and Induces Pro-Inflammatory Innate Immune Response. Viruses. 2017;9: pubmed publisher
    ..effect or infectious progeny production was observed in exocrine cells exposed to the beta cell-tropic strains of E16 and E30...
  82. Neupane S, Adhikari N, Jung J, An C, Lee S, Jun J, et al. Regulation of mesenchymal signaling in palatal mucosa differentiation. Histochem Cell Biol. 2018;149:143-152 pubmed publisher
    ..To reveal this developmental mechanism, first, we conducted tissue recombination assay of the palate at E16 for 2 days which revealed that epithelial differentiation with specific localization of CK10 is modulated by ..
  83. Lim B, Cho K, Lim J, Lee R, Kim H, Kim M, et al. Increased expression of L-amino acid transporters in balloon cells of tuberous sclerosis. Childs Nerv Syst. 2011;27:63-70 pubmed publisher
    ..The amino acid transport system L (LAT) is a major nutrient transport system, and LAT1 is highly expressed in malignant tumors to support tumor cell growth...
  84. Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, et al. Clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with adenoid cystic carcinoma. Pathol Oncol Res. 2013;19:649-56 pubmed publisher
    The expression of L-type amino acid transporter 1 (LAT1) is correlated with tumor cell growth and survival. However, the clinicopathological significance of LAT1 expression in adenoid cystic carcinoma (ACC) remains to be elucidated...
  85. Thapa P, Romero Arocha S, Chung J, Sant Angelo D, Shapiro V. Histone deacetylase 3 is required for iNKT cell development. Sci Rep. 2017;7:5784 pubmed publisher
    ..Interestingly, Hdac3-deficient iNKT cells also have lower expression of the nutrient receptors GLUT1, CD71 and CD98, which would increase the need for autophagy when nutrients are limiting...
  86. Usuki F, Fujimura M, Yamashita A. Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters. Sci Rep. 2017;7:12390 pubmed publisher
    ..preconditioning upregulated the expression of methionine transporters that affect the cellular influx of MeHg, LAT1, LAT3, and SNAT2; and a membrane transporter that affects the efflux of MeHg, ABCC4, in MeHg-susceptible myogenic ..
  87. Shi W, Zhao J, Anderson K, Warburton D. Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2001;280:L1030-9 pubmed
    ..5 and in large airways after E16.5. In E11...
  88. Okubo S, Zhen H, Kawai N, Nishiyama Y, Haba R, Tamiya T. Correlation of L-methyl-11C-methionine (MET) uptake with L-type amino acid transporter 1 in human gliomas. J Neurooncol. 2010;99:217-25 pubmed publisher
    L-type amino acid transporter 1 (LAT1) is a neutral amino acid transport system and is a major route for the transport of large neutral amino acids, including methionine, through the plasma membrane...
  89. Nakamura T, Ueyama T, Ninoyu Y, Sakaguchi H, Choijookhuu N, Hishikawa Y, et al. Novel role of Rac-Mid1 signaling in medial cerebellar development. Development. 2017;144:1863-1875 pubmed publisher
    ..We observed impaired tangential migration at E16.5, as well as numerous apoptotic CGNs at the deepest layer of the external granule layer (EGL) in the medial ..
  90. Kaira K, Sunose Y, Ohshima Y, Ishioka N, Arakawa K, Ogawa T, et al. Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer. BMC Cancer. 2013;13:482 pubmed publisher
    The expression of L-type amino acid transporter 1 (LAT1) has been described to play essential roles in tumor cell growth and survival...
  91. Guo N, Zhang K, Lv M, Miao J, Chen Z, Zhu P. CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells. Mol Immunol. 2015;63:253-63 pubmed publisher
    ..Knocking down CD147 expression resulted in a significant decrease in CD98, along with prominent cell aggregation, similar to that treated by CD98 and CD147 monoclonal antibodies...
  92. Hayashi K, Jutabha P, Maeda S, Supak Y, Ouchi M, Endou H, et al. LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells. J Pharmacol Sci. 2016;132:201-204 pubmed publisher
    L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers...