SLC5A7

Summary

Gene Symbol: SLC5A7
Description: solute carrier family 5 member 7
Alias: CHT, CHT1, CMS20, HMN7A, high affinity choline transporter 1, high affinity choline transporter; hemicholinium-3-sensitive choline transporter, solute carrier family 5 (sodium/choline cotransporter), member 7
Species: human
Products:     SLC5A7

Top Publications

  1. Schmidt S, Moncada M, Burger S, Geyer J. Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes. BMC Neurosci. 2015;16:35 pubmed publisher
    ..these studies, transport by the dopamine transporter DAT, the serotonin transporter SERT, the choline transporter CHT1, the vesicular monoamine transporter VMAT2, the organic cation transporter Oct1, and NTCP were used as positive ..
  2. Nassenstein C, Wiegand S, Lips K, Li G, Klein J, Kummer W. Cholinergic activation of the murine trachealis muscle via non-vesicular acetylcholine release involving low-affinity choline transporters. Int Immunopharmacol. 2015;29:173-80 pubmed publisher
    ..Hemicholinium-3, in low concentrations an inhibitor of the high-affinity choline transporter-1 (CHT1), completely abrogated the eserine effects when applied in high concentrations (10(-4)M) pointing towards an ..
  3. Castellão Santana L, Yumi Abiko P, Ambiel C, Peixoto A, Noronha Matos J, Correia de Sá P, et al. Tetanic Facilitation of Neuromuscular Transmission by Adenosine A2A and Muscarinic M1 Receptors is Dependent on the Uptake of Choline via High-Affinity Transporters. Pharmacology. 2019;103:38-49 pubmed publisher
    ..Data suggest that the recovery of tetanic neuromuscular facilitation by adenosine A2A and M1 receptors is highly dependent on HChT activity and may be weakened in myasthenic patients when HChT is inoperative. ..
  4. Zhou Y, Xia X, Yu G, Wang J, Wu J, Wang M, et al. Brassinosteroids play a critical role in the regulation of pesticide metabolism in crop plants. Sci Rep. 2015;5:9018 pubmed publisher
    ..Genome-wide microarray analysis showed that fungicide chlorothalonil (CHT) and BR co-upregulated 301 genes, including a set of detoxifying genes encoding cytochrome P450, oxidoreductase, ..
  5. Yu G, Zhang Y, Ahammed G, Xia X, Mao W, Shi K, et al. Glutathione biosynthesis and regeneration play an important role in the metabolism of chlorothalonil in tomato. Chemosphere. 2013;90:2563-70 pubmed publisher
    ..the changes of thiols, glutathione homeostasis and transcripts of genes potentially involved in chlorothalonil (CHT) metabolism in tomato (Solanum lycopersicum L.)...
  6. Wang H, Chen Z, Liu G, Bai C, Qiu H, Jia Y, et al. Alterations of growth, antioxidant system and gene expression in Stylosanthes guianensis during Colletotrichum gloeosporioides infection. Plant Physiol Biochem. 2017;118:256-266 pubmed publisher
    ..PR1 and PR5), phenylalanine ammonia lyase (PAL), polyphenol oxidase (PPO), chalcone synthase (CHS) and chitinase (Cht), was differentially enhanced in stylo leaves by C. gloeosporioides...
  7. Stankiewicz A, Goscik J, Dyr W, Juszczak G, Ryglewicz D, Swiergiel A, et al. Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. Pharmacol Biochem Behav. 2015;139:27-38 pubmed publisher
    ..regulation of important addiction-related brain systems such as dopamine, tachykinin or acetylcholine (Gng7, Tac4, Slc5a7). The identified candidate genes may underlie differential ethanol preference in an animal model of alcoholism...
  8. Rył A, Rotter I, Słojewski M, Jędrzychowska A, Marcinowska Z, Grabowska M, et al. Can metabolic disorders in aging men contribute to prostatic hyperplasia eligible for transurethral resection of the prostate (TURP)?. Int J Environ Res Public Health. 2015;12:3327-42 pubmed publisher
    ..The concentrations of glucose were determined, as well as total cholesterol (ChT), low-density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides (TAG), by spectrophotometric ..
  9. Schütz B, Jurastow I, Bader S, Ringer C, von Engelhardt J, Chubanov V, et al. Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract. Front Physiol. 2015;6:87 pubmed publisher
    ..While all EGFP (ChAT) cells were also ChAT-positive, expression of the high-affinity choline transporter (ChT1) was never detected...

More Information

Publications140 found, 100 shown here

  1. Camargo R, Batista T, Ribeiro R, Branco R, da Silva P, Izumi C, et al. Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet. Amino Acids. 2015;47:2419-35 pubmed publisher
    ..Thereafter, mice received, or not, HFD for 8 weeks (CH and RH) with or without 5 % Tau supplementation (CHT and RHT). Protein restriction led to higher food intake, but calories were matched to controls...
  2. Dimri M, Joshi J, Chakrabarti R, Sehgal N, Sureshbabu A, Kumar I. Todralazine protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion. Zebrafish. 2015;12:33-47 pubmed publisher
    ..Todralazine (5 μM) significantly increased erythropoiesis in caudal hematopoietic tissue (CHT) in wild-type and anemic zebrafish embryos (2.33- and 1...
  3. Freeling J, Li Y. Age-related attenuation of parasympathetic control of the heart in mice. Int J Physiol Pathophysiol Pharmacol. 2015;7:126-35 pubmed
    ..In contrast, the upper band of the high affinity choline transporter (CHT) was significantly upregulated in the older group...
  4. Yoder A, Gunther J, Milgrom S, Mirkovic D, Nastoupil L, Neelapu S, et al. Hitting a Moving Target: Successful Management of Diffuse Large B-cell Lymphoma Involving the Mesentery With Volumetric Image-guided Intensity Modulated Radiation Therapy. Clin Lymphoma Myeloma Leuk. 2019;19:e51-e61 pubmed publisher
    ..All patients received frontline chemotherapy (ChT) (R-CHOP [rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone], n = 19; dose-adjusted R-EPOCH [..
  5. Visan A, Stan G, Ristoscu C, Popescu Pelin G, Sopronyi M, Beşleagă C, et al. Combinatorial MAPLE deposition of antimicrobial orthopedic maps fabricated from chitosan and biomimetic apatite powders. Int J Pharm. 2016;511:505-515 pubmed publisher
    ..FTIR, EDS and XPS analyses indicated that the composition of the BmAp-CHT C-MAPLE composite films gradually modified from pure apatite to chitosan. The bioevaluation tests indicated that S...
  6. Bouman W, Claes L, Marshall E, Pinner G, Longworth J, Maddox V, et al. Sociodemographic Variables, Clinical Features, and the Role of Preassessment Cross-Sex Hormones in Older Trans People. J Sex Med. 2016;13:711-9 pubmed publisher
    ..of older trans people attending a national service and to investigate the influence of cross-sex hormones (CHT) on psychopathology...
  7. Kaji I, Akiba Y, Konno K, Watanabe M, Kimura S, Iwanaga T, et al. Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon. J Physiol. 2016;594:3339-52 pubmed publisher
    ..5, the vesicular ACh transporter, and the high-affinity choline transporter CHT1. In Ussing chambered mucosa-submucosa preparations (including the submucosal plexus) of rat proximal colon, ..
  8. Chen C, Yang H, Tang B, Yang W, Jin D. Identification and functional analysis of chitinase 7 gene in white-backed planthopper, Sogatella furcifera. Comp Biochem Physiol B Biochem Mol Biol. 2017;208-209:19-28 pubmed publisher
    ..In this study, the full-length cDNA sequence of a Cht gene (SfCht7) was identified and characterized from the white-black planthopper, Sogatella furcifera...
  9. Sakata K, Overacre A. Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments. J Neurochem. 2017;143:49-64 pubmed publisher
    ..addressed this question by determining mRNA levels of 22 acetylcholine receptor subunits, the choline transporter (CHT), and the choline acetyltransferase (ChAT) in mice deficient in activity-dependent BDNF via promoter IV (KIV) and ..
  10. Mahony C, Fish R, Pasche C, Bertrand J. tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 2016;128:1336-45 pubmed publisher
    ..In zebrafish, HSCs emerge from the dorsal aorta and colonize the caudal hematopoietic tissue (CHT)...
  11. Pandiyaraj K, Ramkumar M, Arun Kumar A, Padmanabhan P, Pichumani M, Bendavid A, et al. Evaluation of surface properties of low density polyethylene (LDPE) films tailored by atmospheric pressure non-thermal plasma (APNTP) assisted co-polymerization and immobilization of chitosan for improvement of antifouling properties. Mater Sci Eng C Mater Biol Appl. 2019;94:150-160 pubmed publisher
    ..In a second stage, the plasma copolymerized LDPE films were functionalized with chitosan (CHT) to further enhance its antifouling properties...
  12. Gu Y, Thompson D, Xu J, Lewis D, Morgan J, Cooper D, et al. Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia. Pregnancy Hypertens. 2018;11:1-6 pubmed publisher
    ..venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia)...
  13. D Souza A, Desai S, Rudner X, Kelly M, Ruan S, Shellito J. Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. PLoS ONE. 2013;8:e56890 pubmed publisher
    ..that ethanol impairs proteasome function in peritoneal macrophages through suppression of chymotrypsin-like (Cht-L) proteasome activity as well as composition of the immunoproteasome subunit LMP7...
  14. Chotirat S, Suriyo T, Hokland M, Hokland P, Satayavivad J, Auewarakul C. Cholinergic activation enhances retinoic acid-induced differentiation in the human NB-4 acute promyelocytic leukemia cell line. Blood Cells Mol Dis. 2016;59:77-84 pubmed publisher
    ..a heterogeneous expression of choline acetyltransferase (ChAT), acetylcholinesterase (AChE), choline transporter (CHT), M3 muscarinic acetylcholine receptor (M3-mAChR) and α7 nicotinic acetylcholine receptor (α7-nAChR)...
  15. Cebolla J, Irún P, Mozas P, Giraldo P. Evaluation of two approaches to lysosomal acid lipase deficiency patient identification: An observational retrospective study. Atherosclerosis. 2019;285:49-54 pubmed publisher
    ..Our purpose was to explore the utility of plasma chitotriosidase activity (ChT) and CCL18/PARC concentration in addition to LLP to identify LALD patients in an observational retrospective study ..
  16. Zhang X, Jiang X, Huang L, Tian W, Chen X, Gu X, et al. Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice. Brain Behav. 2018;8:e00957 pubmed publisher
    ..of acetylcholine transferase (ChAT), AChE, vesicular acetylcholine transporter (VAChT), and choline transporter (ChT) in the prefrontal cortex (PFC)...
  17. Rodríguez Cruz P, Palace J, Beeson D. The Neuromuscular Junction and Wide Heterogeneity of Congenital Myasthenic Syndromes. Int J Mol Sci. 2018;19: pubmed publisher
    ..CMS due to mutations in SLC5A7 and SLC18A3, impairing the synthesis and recycling of acetylcholine, have recently been described...
  18. Han S, Yang S, Kim J, Mo S, Yang E, Song K, et al. Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior. Sci Rep. 2017;7:900 pubmed publisher
    ..Here, we demonstrated that the expression levels of cholinergic signaling genes (CHAT, VACHT, CHT, CHRNA3, CHRNB3 and CHRNB4) were down-regulated in a chronic restraint stress (CRS) rat model of depression, in ..
  19. Minkner R, Baba R, Kurosawa Y, Suzuki S, Kato T, Kobayashi S, et al. Purification of human papillomavirus-like particles expressed in silkworm using a Bombyx mori nucleopolyhedrovirus bacmid expression system. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1096:39-47 pubmed publisher
    ..Using the two separation principles of cation exchange chromatography and metal affinity of ceramic hydroxyapatite (CHT) as a second stage, the amount of baculovirus in the sample was reduced to less than the detection limit of qPCR...
  20. Guattini V, Piovesan C, Wittke E, Marcadenti A. HYPERTRIGLYCERIDEMIC WAIST (EWET), GLYCIDIC AND LIPID PROFILE IN PATIENTS WITH NEWLY DIAGNOSED HEART ATTACK. Nutr Hosp. 2015;32:1004-8 pubmed publisher
    ..Introducción: el fenotipo de la cintura hipertrigliceridémica (CHT) ha sido poco estudiado en pacientes con enfermedad cardiovascular establecida...
  21. Godény M, Remenar E, Takácsi Nagy Z, Petri K, Horvath K, Bocs K, et al. [Role of MRI and CT in the evaluation of postirradiation status and complications in head and neck cancer]. Magy Onkol. 2018;62:159-173 pubmed
    ..and neck cancer patients are treated with combined modalities such as surgery, radiotherapy (RT), chemotherapy (ChT). Concurrent chemo-radiation has improved treatment outcomes with increased toxic effects...
  22. Vale A, Pereira P, Barbosa A, Torrado E, Mano J, Alves N. Antibacterial free-standing polysaccharide composite films inspired by the sea. Int J Biol Macromol. 2019;: pubmed publisher
    ..Herein, novel antibacterial free-standing (FS) films were developed with natural polymers, namely chitosan (CHT) and hyaluronic acid (HA), being the catechol-functionalized hyaluronic acid (HA-DN) also included to provide wet ..
  23. Lee B, Sur B, Shim J, Hahm D, Lee H. Acupuncture stimulation improves scopolamine-induced cognitive impairment via activation of cholinergic system and regulation of BDNF and CREB expressions in rats. BMC Complement Altern Med. 2014;14:338 pubmed publisher
    ..Additionally, acupuncture stimulation at GV20 significantly restored the expression of choline transporter 1 (CHT1), vesicular acetylcholine transporter (VAChT), BDNF and CREB mRNA in the hippocampus...
  24. Lundwall R, Dannemiller J, Goldsmith H. Genetic associations with reflexive visual attention in infancy and childhood. Dev Sci. 2017;20: pubmed publisher
    ..polymorphisms and variable number tandem repeats on the genes APOE, BDNF, CHRNA4, COMT, DRD4, HTR4, IGF2, MAOA, SLC5A7, SLC6A3, and SNAP25) are related to brain development and/or to the availability of neurotransmitters such as ..
  25. Foerster R, Kluck R, Arians N, Rieken S, Rief H, Adeberg S, et al. Lymphadenectomy in women with endometrial cancer: aspiration and reality from a radiation oncologist's point of view. Radiat Oncol. 2015;10:147 pubmed publisher
    ..8 % sampling of suspicious lymph nodes, 15.6 % no LNE. Adjuvant chemotherapy (ChT): 3.2 %. Sole intravaginal brachytherapy (IVB): 60.2 %. IVB + external beam radiotherapy (EBRT): 39.8 %...
  26. Ferreira Vieira T, Guimaraes I, Silva F, Ribeiro F. Alzheimer's disease: Targeting the Cholinergic System. Curr Neuropharmacol. 2016;14:101-15 pubmed
    ..and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1)...
  27. Pinzón García A, Orellano L, de Lazari M, Campos P, Cortés M, Sinisterra R. Evidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the Bixin and Bixin: β-CD inclusion compound in high-fat-fed obese mice. Biomed Pharmacother. 2018;106:363-372 pubmed publisher
    ..Body weight, Lee's Index, adiposity, CHT, TG, CHT/HDL-c, glucose levels (metabolic markers) and, liver markers (AST and ALT) were determined...
  28. Valdes K, Naughton N, Burke C. Therapist-supervised hand therapy versus home therapy with therapist instruction following distal radius fracture. J Hand Surg Am. 2015;40:1110-6.e1 pubmed publisher
    ..with and without comorbidities who receive regular supervised therapy provided by a certified hand therapist (CHT) compared with patients who were provided with a home exercise program and were regularly monitored...
  29. Frenzel T, Siekmann J, Grohmann C, Valentiner U, Schmitz R, Riecken K, et al. Locally Ablative Radiation Therapy of a Primary Human Small Cell Lung Cancer Tumor Decreases the Number of Spontaneous Metastases in Two Xenograft Models. Int J Radiat Oncol Biol Phys. 2018;100:1044-1056 pubmed publisher
    To investigated the influence of radiation therapy (RT), surgery (OP), radio-chemotherapy (RChT), or chemotherapy (ChT) on small cell lung cancer metastases in 2 xenograft models...
  30. Singh P, Medronho B, Valente A, Miguel M, Lindman B. Exploring the prebiotic effect of cyclodextrins on probiotic bacteria entrapped in carboxymetyl cellulose-chitosan particles. Colloids Surf B Biointerfaces. 2018;168:156-162 pubmed publisher
    ..of model probiotic bacteria (Lactobacillus rhamnosus GG) encapsulated in carboxymethyl cellulose-chitosan (CMC-Cht) hybrid particles was studied...
  31. Sousa M, Neto A, Correia T, Miguel S, Matsusaki M, Correia I, et al. Bioinspired multilayer membranes as potential adhesive patches for skin wound healing. Biomater Sci. 2018;6:1962-1975 pubmed publisher
    Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN)...
  32. Iwao B, Yara M, Hara N, Kawai Y, Yamanaka T, Nishihara H, et al. Functional expression of choline transporter like-protein 1 (CTL1) and CTL2 in human brain microvascular endothelial cells. Neurochem Int. 2016;93:40-50 pubmed publisher
    ..protein 1 (CTL1) and CTL2 mRNA were highly expressed, while mRNA for high-affinity choline transporter 1 (CHT1) and organic cation transporters (OCTs) were not expressed in hBMECs...
  33. Cai P, Mao X, Zhao J, Luo L. Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochem Biophys Res Commun. 2018;497:776-782 pubmed publisher
    ..Urb2 is strongly expressed in the caudal hematopoietic tissue (CHT) during hematopoietic stem cells (HSCs) expanding...
  34. Del Pino J, Moyano P, Anadon M, García J, Díaz M, García J, et al. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. 2015;336:1-9 pubmed publisher
    ..that CPF impaired cholinergic transmission, induced AChE inhibition and, only after long-term exposure, increased CHT expression, which suggests that acetylcholine levels alteration could be mediated by these actions...
  35. Seedat N, Kalhapure R, Mocktar C, Vepuri S, Jadhav M, Soliman M, et al. Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid-polymer hybrid nanoparticles: In vitro and in silico studies. Mater Sci Eng C Mater Biol Appl. 2016;61:616-30 pubmed publisher
    ..Oleic acid (OA), Chitosan (CHT) and Sodium alginate (ALG) were explored as co-excipients...
  36. Dou Y, Luo J, Wu X, Wei Z, Tong B, Yu J, et al. Curcumin attenuates collagen-induced inflammatory response through the "gut-brain axis". J Neuroinflammation. 2018;15:6 pubmed publisher
    ..The expression of the high-affinity choline transporter 1 (CHT1), ChAT, and vesicular acetylcholine transporter (VAChT) were determined by real-time PCR and immunohistochemical ..
  37. Holubec L, Polivka J, Lisnerova L, Kubíková T, Safanda M. The Effectiveness of Febrile Neutropenia Prophylaxis with Lipegfilgrastim in Routine Clinical Practice. In Vivo. 2017;31:303-306 pubmed
    ..of lipegfilgrastim can almost eliminate the risk of FN and significantly reduce the risk of chemotherapy (CHT) dose reduction in routine clinical practice in cases of a clear high-risk chemotherapy regimen or in the presence ..
  38. Ma H, Hao P, Zhang L, Ma C, Yan P, Wang R, et al. A new cyclic RGD peptide dimer for integrin αvβ3 imaging. Eur Rev Med Pharmacol Sci. 2016;20:613-9 pubmed
    ..131I-c(RGD)2 was synthesized using the chloramine-T (ChT) method, and the octanol-water partition coefficient was experimentally measured...
  39. Stegink Jansen C, Collins P, Lindsey R, Wilson J. A geographical workforce analysis of hand therapy services in relation to US population characteristics. J Hand Ther. 2017;30:383-396.e1 pubmed publisher
    ..of US Certified Hand Therapists (CHTs) and describe characteristics of US populations living in respective CHT workplace Zip Code Tabulation Areas (ZCTAs)...
  40. Vercelli S, Ferriero G, Bravini E, Al Yazeedi W, Salgovic L, Caligari M, et al. A simple orthosis solves a problem in a patient with a dystonic finger after stroke. J Hand Ther. 2017;30:113-115 pubmed publisher
    ..Clinical observation and reasoning resulted in an effective solution to control the dystonia that was acceptable to the client. - Kristin Valdes, OTD, OT, CHT, Practice Forum Editor.
  41. Navarria P, Pessina F, Tomatis S, Soffietti R, Grimaldi M, Lopci E, et al. Are three weeks hypofractionated radiation therapy (HFRT) comparable to six weeks for newly diagnosed glioblastoma patients? Results of a phase II study. Oncotarget. 2017;8:67696-67708 pubmed publisher
    ..surgical resection, followed by radiation therapy (RT) with concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT). The patients outcome is still poor...
  42. Jung J, Kasi G, Seo J. Development of functional antimicrobial papers using chitosan/starch-silver nanoparticles. Int J Biol Macromol. 2018;112:530-536 pubmed publisher
    In the present work, we report the synthesis of chitosan:starch?silver nanoparticle (Cht:St-AgNPs) coated papers for antimicrobial packaging applications...
  43. Ozge G, Koylu M, Mumcuoglu T, Gundogan F, Ozgonul C, Ayyildiz O, et al. Evaluation of retinal nerve fiber layer thickness and choroidal thickness in pseudoexfoliative glaucoma and pseudoexfoliative syndrome. Postgrad Med. 2016;128:444-8 pubmed publisher
    To compare retinal nerve fiber layer thickness (RNFLT) and choroidal thickness (ChT) measurements in eyes with pseudoexfoliative (PEX) glaucoma, PEX syndrome and healthy control eyes...
  44. Branco R, Camargo R, Batista T, Vettorazzi J, Borck P, Dos Santos Silva J, et al. Protein malnutrition blunts the increment of taurine transporter expression by a high-fat diet and impairs taurine reestablishment of insulin secretion. FASEB J. 2017;31:4078-4087 pubmed publisher
    ..HFD (CH) and RD + HFD (RH)] with or without 5% Tau supplementation after weaning on their drinking water [CH + Tau (CHT) and RH + Tau (RHT)]. The HFD increased insulin secretion through mitochondrial metabolism in CH and RH...
  45. Crasson O, Courtade G, Léonard R, Aachmann F, Legrand F, Parente R, et al. Human Chitotriosidase: Catalytic Domain or Carbohydrate Binding Module, Who's Leading HCHT's Biological Function. Sci Rep. 2017;7:2768 pubmed publisher
    ..This observation may also be a general feature of GHs. Altogether, our data have led us to postulate and discuss that HCHT acts as an immune catalyser. ..
  46. Kalmár A, Wichmann B, Galamb O, Spisák S, Tóth K, Leiszter K, et al. Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples. Diagn Pathol. 2015;10:126 pubmed publisher
    ..cancer-specific marker set with 11 genes (CA7, COL12A1, CXCL1, CXCL2, CHI3L1, GREM1, IL1B, IL1RN, IL8, MMP3, SLC5A7) was performed with array real-time PCR using Transcriptor First Strand cDNA Synthesis Kit (Roche) and RealTime ..
  47. Hamorsky K, Matoba N. Facile Method for the Production of Recombinant Cholera Toxin B Subunit in E. coli. Methods Mol Biol. 2016;1404:511-8 pubmed publisher
    ..chromatography process: immobilized metal affinity chromatography (IMAC) followed by ceramic hydroxyapatite (CHT). CTB is purified to >95 % homogeneity with a yield of over 10 mg per liter of culture...
  48. Hepp P, Andergassen U, Jäger B, Trapp E, Alunni Fabbroni M, Friedl T, et al. Association of CA27.29 and Circulating Tumor Cells Before and at Different Times After Adjuvant Chemotherapy in Patients with Early-stage Breast Cancer - The SUCCESS Trial. Anticancer Res. 2016;36:4771-6 pubmed
    ..29. Here we report the association of these two prognostic markers before and immediately after chemotherapy (CHT), as well as after 2 and 5 years of follow-up...
  49. Sas Korczyńska B, Łuczyńska E, Kamzol W, Sokołowski A. Analysis of risk factors for pulmonary complications in patients with limited-stage small cell lung cancer : A single-centre retrospective study. Strahlenther Onkol. 2017;193:141-149 pubmed publisher
    ..The influence of chemoradiotherapy (ChT-RT) schedule on treatment results (frequency of complete response, survival rates, and incidence of treatment ..
  50. De Castro Orós I, Irún P, Cebolla J, Rodríguez Sureda V, Mallen M, Pueyo M, et al. Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study. J Transl Med. 2017;15:43 pubmed publisher
    ..This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction ..
  51. Suarez J, Marín G, Vera R, Colibaseanu D, Vila J, Ciga M, et al. Stent placement prior to initiation of chemotherapy in patients with obstructive, nonoperative left sided tumors is associated with fewer stomas. J Surg Oncol. 2017;115:856-863 pubmed publisher
    ..colostomy formation, and survival between stent placement prior to start of chemotherapy (SEMS group) and upfront ChT (ChT group) in patients with endoscopically non-transverable metastatic left-sided colorectal cancer...
  52. Liu H, Wu J, Ge Y, Li A, Li J, Liu Z, et al. Novel aromatic sulfonyl naphthalene-based boronates as 20S proteasome inhibitors. Bioorg Med Chem. 2018;26:1050-1061 pubmed publisher
    A novel series of non-peptide proteasome inhibitors (PIs) that act on chymotrypsin-like (ChT-L) of the proteasome were developed...
  53. Iwamoto H, Calcutt M, Blakely R. Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine. Neurochem Int. 2016;98:138-45 pubmed publisher
    ..import of choline into cholinergic nerve terminals by the presynaptic, high-affinity choline transporter (CHT, SLC5A7) dictates the capacity for acetylcholine (ACh) synthesis and release...
  54. Domingues R, Chiera S, Gershovich P, Motta A, Reis R, Gomes M. Enhancing the Biomechanical Performance of Anisotropic Nanofibrous Scaffolds in Tendon Tissue Engineering: Reinforcement with Cellulose Nanocrystals. Adv Healthc Mater. 2016;5:1364-75 pubmed publisher
    ..aligned electrospun scaffolds based on a natural/synthetic polymer blend matrix, poly-?-caprolactone/chitosan (PCL/CHT) is reported...
  55. Nagao Y, Hirayama S, Kon M, Sasamoto K, Sugihara M, Hirayama A, et al. Current smokers with hyperlipidemia lack elevated pre?1-high-density lipoprotein concentrations. J Clin Lipidol. 2017;11:242-249 pubmed publisher
    ..We measured the pre?1-HDL concentration and lecithin-cholesterol acyltransferase-dependent conversion rate (CHTpre?1) in 74 men (39 nonsmokers and 35 smokers) using an immunoassay...
  56. Shaw J, Varni S, Tolmie E, Mohlman M, Harder V. Successful Integration of Pediatrics Into State Health Care Reform Efforts. J Pediatr Health Care. 2018;32:e1-e8 pubmed publisher
    ..initially focused on adult primary care, to pediatrics through interviews with project managers and facilitators, CHT members, pediatric practitioners and care coordinators, and community-based providers...
  57. Picchio M, Giovannini E, Passoni P, Busnardo E, Landoni C, Giovacchini G, et al. Role of PET/CT in the clinical management of locally advanced pancreatic cancer. Tumori. 2012;98:643-51 pubmed publisher
    ..PET/CT in: a) the selection of patients with locally advanced pancreatic cancer for helical tomotherapy with concurrent chemotherapy (HTT-ChT); b) monitoring HTT-ChT treatment efficacy in comparison with contrast-enhanced CT (c.e.CT).
  58. Zhang Z, Chan A, Ding X, Qin Z, Hong C, Chen L, et al. TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas. Oncotarget. 2015;6:24871-83 pubmed publisher
    ..in WHO grade II and II diffuse gliomas predict enhanced sensitivity to adjuvant radiation (RT) or chemotherapy (CHT) is still being debated...
  59. Carvalho C, Lopez Cebral R, Silva Correia J, Silva J, Mano J, Silva T, et al. Investigation of cell adhesion in chitosan membranes for peripheral nerve regeneration. Mater Sci Eng C Mater Biol Appl. 2017;71:1122-1134 pubmed publisher
    ..Chitosan (CHT), because of its good biocompatibility, biodegradability and physicochemical properties, has been widely used as a ..
  60. Maurel J, Postigo A. Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice. Curr Cancer Drug Targets. 2015;15:703-15 pubmed
    ..First-line therapy in mCRC combines conventional chemotherapy (CHT) (e.g., FOLFOX, FOLFIRI, CAPOX) with a number of agents targeted to specific signaling pathways (TA) (e.g...
  61. Eide K, Stockinger L, Lewin A, Tøndervik A, Eijsink V, Sørlie M. The role of active site aromatic residues in substrate degradation by the human chitotriosidase. Biochim Biophys Acta. 2016;1864:242-7 pubmed publisher
    ..Such behavior contrast that of the wild type and HCHT-W218A and resembles the action of endo-nonprocessive chitinases. ..
  62. Inwald E, Ortmann O, Koller M, Zeman F, Hofstadter F, Evert M, et al. Screening-relevant age threshold of 70 years and older is a stronger determinant for the choice of adjuvant treatment in breast cancer patients than tumor biology. Breast Cancer Res Treat. 2017;163:119-130 pubmed publisher
    ..As to Luminal A patients, best OS was seen in patients receiving endocrine therapy (ET) (7-year OS of 95.6%) and CHT plus ET (7-year OS of 93.1%) in the ESG...
  63. Turan S, Aksoy Poyraz C, Usta Sağlam N, Demirel O, Haliloglu O, Kadioglu P, et al. Alterations in Body Uneasiness, Eating Attitudes, and Psychopathology Before and After Cross-Sex Hormonal Treatment in Patients with Female-to-Male Gender Dysphoria. Arch Sex Behav. 2018;47:2349-2361 pubmed publisher
    ..Cross-sex hormonal treatment (CHT) alleviates the dissatisfaction by making various changes in the body...
  64. Bulut A, Oner V, Büyüktarakçı Ş, Kaim M. Associations between choroidal thickness, axial length and spherical equivalent in a paediatric population. Clin Exp Optom. 2016;99:356-9 pubmed publisher
    The aim was to compare the choroidal thickness (ChT) of myopic children's eyes with that of emmetropes to determine whether there are associations between ChT, axial length and spherical equivalent (SE) in a paediatric population...
  65. Keller J, Caro C, Dimick M, Landrieu K, Fullenwider L, Walsh J. Thirty years of hand therapy: The 2014 practice analysis. J Hand Ther. 2016;29:222-34 pubmed publisher
    ..study was to gather data on current hand therapy practice to ensure the content of the Certified Hand Therapist (CHT) examination and credentialing program requirements match current practice...
  66. Yan G, Li A, Zhang A, Sun Y, Liu J. Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..to develop new therapies, among which combined therapies including photothermal therapy (PTT) and chemotherapy (CHT) using polymer-based nanocarriers have attracted enormous interest due to the significantly enhanced efficacy and ..
  67. Thouchprasitchai N, Pintuyothin N, Pongstabodee S. Optimization of CO2 adsorption capacity and cyclical adsorption/desorption on tetraethylenepentamine-supported surface-modified hydrotalcite. J Environ Sci (China). 2018;65:293-305 pubmed publisher
    ..adsorption capacity of tetraethylenepentamine-functionalized basic-modified calcined hydrotalcite (TEPA/b-cHT) sorbents at atmospheric pressure formed under varying TEPA loading levels, temperatures, sorbent weight to total ..
  68. Holmstrand E, Asafu Adjei J, Sampson A, Blakely R, Sesack S. Ultrastructural localization of high-affinity choline transporter in the rat anteroventral thalamus and ventral tegmental area: differences in axon morphology and transporter distribution. J Comp Neurol. 2010;518:1908-24 pubmed publisher
    The high-affinity choline transporter (CHT) is a protein integral to the function of cholinergic neurons in the central nervous system (CNS)...
  69. Parikh V, St Peters M, Blakely R, Sarter M. The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attention. J Neurosci. 2013;33:2326-37 pubmed publisher
    Functional variation in the gene encoding the presynaptic choline transporter (CHT) has been linked to attention-deficit/hyperactivity disorder...
  70. Berry A, Demeter E, Sabhapathy S, English B, Blakely R, Sarter M, et al. Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects. J Cogn Neurosci. 2014;26:1981-91 pubmed publisher
    ..with a polymorphism limiting cholinergic capacity (Ile89Val variant [rs1013940] of the choline transporter gene SLC5A7) and matched controls completed self-report measures of attention and a laboratory task that measured decrements ..
  71. Jeremic B, Fidarova E, Sharma V, Faheem M, Ameira A, Nasr Ben Ammar C, et al. The International Atomic Energy Agency (IAEA) randomized trial of palliative treatment of incurable locally advanced non small cell lung cancer (NSCLC) using radiotherapy (RT) and chemotherapy (CHT) in limited resource setting. Radiother Oncol. 2015;116:21-6 pubmed publisher
    ..randomized study (NCT00864331) comparing protracted palliative radiotherapy (RT) course with chemotherapy (CHT) followed by short-course palliative RT...
  72. Blaser B, Moore J, Hagedorn E, Li B, Riquelme R, Lichtig A, et al. CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017;214:1011-1027 pubmed publisher
    ..marking fluorescent HSPCs have allowed exquisite visualization of HSPCs in the caudal hematopoietic tissue (CHT) of the developing zebrafish...
  73. Cuddy L, Seah C, Pasternak S, Rylett R. Amino-Terminal ?-Amyloid Antibody Blocks ?-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT. Front Mol Neurosci. 2017;10:361 pubmed publisher
    ..The high-affinity choline transporter (CHT) is present at the presynaptic cholinergic nerve terminal and is responsible for the reuptake of choline produced ..
  74. Haberberger R, Pfeil U, Lips K, Kummer W. Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin. J Invest Dermatol. 2002;119:943-8 pubmed
  75. Xie J, Guo Q. Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. J Biol Chem. 2004;279:28266-75 pubmed
    b>CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter...
  76. Cella L, Liuzzi R, Romanelli P, Conson M, D Avino V, Ottaviano M, et al. Predictors of Asymptomatic Radiation-induced Abdominal Atherosclerosis. Clin Oncol (R Coll Radiol). 2017;29:e186-e194 pubmed publisher
    ..post-surgery radiotherapy (median total dose 25 Gy, range 25-43), two of them also received chemotherapy (CHT) and 16 patients were treated with surgery alone or by surgery followed by CHT (control group)...
  77. Lichtenstein C, Cora Bramble D, Ottolini M, Agrawal D. Is There a Return on a Children's Hospital's Investment in a Pediatric Residency's Community Health Track? A Cost Analysis. J Community Health. 2018;43:372-377 pubmed publisher
    ..from the 2010-2011 academic year, we quantified total direct costs per year for training 12 community health track (CHT) residents...
  78. Geldenhuys W, Allen D. The blood-brain barrier choline transporter. Cent Nerv Syst Agents Med Chem. 2012;12:95-9 pubmed
    ..The information gained here could increase the success rate in successful CNS drug delivery and therapeutics. ..
  79. Hovhannisyan A, Pham T, Bouvier D, Tan X, Touhar S, Mkryan G, et al. Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome ?1 and ?5 subunits. Bioorg Med Chem Lett. 2017;27:5172-5178 pubmed publisher
    ..Noticeable inhibition of both ChT-L and PA activities was obtained with three compounds: one with unsubstituted phenoxypropanolamine group (7) and ..
  80. van Valenberg F, van der Heijden A, Lammers R, Falke J, Arends T, Oosterwijk E, et al. Intravesical radiofrequency induced hyperthermia enhances mitomycin C accumulation in tumour tissue. Int J Hyperthermia. 2017;:1-6 pubmed publisher
    ..Therefore, alternatives such as radiofrequency-induced chemohyperthermia (RF-CHT) with MMC are being investigated. The mechanism explaining the efficacy of RF-CHT is only partly understood...
  81. Iwamoto H, Blakely R, De Felice L. Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles. J Neurosci. 2006;26:9851-9 pubmed
    ..This mechanism would allow cholinergic, activity-triggered delivery of silent choline transporters to the plasma membrane, in which normal pH would reactivate the transporters for choline uptake and subsequent acetylcholine synthesis. ..
  82. Yamada H, Imajoh Ohmi S, Haga T. The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2. Biomed Res. 2012;33:1-8 pubmed
    The high-affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons, constitutes a rate-limiting step for acetylcholine synthesis...
  83. Luo D, Chen L, Yu B. Inhibition of the high affinity choline transporter enhances hyperalgesia in a rat model of chronic pancreatitis. Biochem Biophys Res Commun. 2017;488:204-210 pubmed publisher
    ..We hypothesized that the high affinity choline transporter CHT1, which is a main determinant of cholinergic signaling capacity, is involved in regulating pain associated with CP...
  84. Oda Y, Muroishi Y, Misawa H, Suzuki S. Comparative study of gene expression of cholinergic system-related molecules in the human spinal cord and term placenta. Neuroscience. 2004;128:39-49 pubmed
    ..acetyltransferase [ChAT], vesicular acetylcholine transporter [VAChT], and a high-affinity choline transporter [CHT1]), and gene regulatory molecules (repressor element-1 silencing transcription factor/neuron-restrictive silencer ..
  85. Barwick K, Wright J, Al Turki S, McEntagart M, Nair A, Chioza B, et al. Defective presynaptic choline transport underlies hereditary motor neuropathy. Am J Hum Genet. 2012;91:1103-7 pubmed publisher
    ..of DNA samples from subjects with distal hereditary motor neuropathy type VII, we identified a mutation in SLC5A7, which encodes the presynaptic choline transporter (CHT), a critical determinant of synaptic acetylcholine ..
  86. Sturdza A, Hofmann S, Kranawetter M, Polterauer S, Grimm C, Krainer M, et al. Increased genitourinary fistula rate after bevacizumab in recurrent cervical cancer patients initially treated with definitive radiochemotherapy and image-guided adaptive brachytherapy. Strahlenther Onkol. 2017;193:1056-1065 pubmed publisher
    ..IGABT) as primary treatment are currently treated in our institution with palliative intent by chemotherapy (CHT) combined with bevacizumab (BEV)...
  87. Wang H, Salter C, Refai O, Hardy H, Barwick K, Akpulat U, et al. Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Brain. 2017;140:2838-2850 pubmed publisher
    ..These findings underscore the essential role played by the choline transporter in sustaining acetylcholine neurotransmission at both central and neuromuscular synapses, with important implications for treatment and drug selection. ..
  88. Pfeil U, Haberberger R, Lips K, Eberling L, Grau V, Kummer W. Expression of the high-affinity choline transporter CHT1 in epithelia. Life Sci. 2003;72:2087-90 pubmed
    Uptake of choline by the high-affinity choline transporter CHT1 is the rate-limiting step in neuronal acetylcholine (ACh) synthesis...
  89. Harrington A, Lee M, Ong S, Yong E, Farmer P, Peck C, et al. Immunoreactivity for high-affinity choline transporter colocalises with VAChT in human enteric nervous system. Cell Tissue Res. 2010;341:33-48 pubmed publisher
    ..Choline reuptake at the synapse occurs via the high-affinity choline transporter (CHT1)...
  90. Hermenean A, Codreanu A, Herman H, Baltă C, Rosu M, Mihali C, et al. Chitosan-Graphene Oxide 3D scaffolds as Promising Tools for Bone Regeneration in Critical-Size Mouse Calvarial Defects. Sci Rep. 2017;7:16641 pubmed publisher
    ..this study was designed to investigate osteogenic differentiation, along with bone repair capacity of 3D chitosan (CHT) scaffolds enriched with graphene oxide (GO) in critical-sized mouse calvarial defect...
  91. Neumann S, Linder K, Muldoon M, Sutton Tyrrell K, Kline C, Shrader C, et al. Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans. Int J Cardiovasc Imaging. 2012;28:243-50 pubmed publisher
    ..Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media ..
  92. Singh P, Medronho B, Alves L, Da Silva G, Miguel M, Lindman B. Development of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria. Carbohydr Polym. 2017;175:87-95 pubmed publisher
    Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods...