SLC5A1

Summary

Gene Symbol: SLC5A1
Description: solute carrier family 5 member 1
Alias: D22S675, NAGT, SGLT1, sodium/glucose cotransporter 1, Na+/glucose cotransporter 1, high affinity sodium-glucose cotransporter, solute carrier family 5 (sodium/glucose cotransporter), member 1
Species: human
Products:     SLC5A1

Top Publications

  1. Martin M, Turk E, Lostao M, Kerner C, Wright E. Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption. Nat Genet. 1996;12:216-20 pubmed
    ..ion gradients to drive 'active' transport of substrates into cells, for example, the Na+/glucose cotransporter (SGLT1) couples sugar transport to Na+ gradients across the intestinal brush border...
  2. Turk E, Kerner C, Lostao M, Wright E. Membrane topology of the human Na+/glucose cotransporter SGLT1. J Biol Chem. 1996;271:1925-34 pubmed
    The membrane topology of the human Na+/glucose cotransporter SGLT1 has been probed using N-glycosylation scanning mutants and nested truncations. Functional analysis proved essential for establishment of signal-anchor topology...
  3. Quick M, Tomasevic J, Wright E. Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles. Biochemistry. 2003;42:9147-52 pubmed
    ..Taken together, these results confirm the successful employment of E. coli to express and characterize a human membrane protein (hSGLT1), elucidating the functional asymmetry of this cotransporter. ..
  4. Loo D, Hirayama B, Karakossian M, Meinild A, Wright E. Conformational dynamics of hSGLT1 during Na+/glucose cotransport. J Gen Physiol. 2006;128:701-20 pubmed
    This study examines the conformations of the Na(+)/glucose cotransporter (SGLT1) during sugar transport using charge and fluorescence measurements on the human SGLT1 mutant G507C expressed in Xenopus oocytes...
  5. Hummel C, Lu C, Loo D, Hirayama B, Voss A, Wright E. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011;300:C14-21 pubmed publisher
    ..Our electrophysiological study provides groundwork for a molecular understanding of how hSGLT inhibitors affect renal glucose reabsorption. ..
  6. Diez Sampedro A, Loo D, Wright E, Zampighi G, Hirayama B. Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454. Biochemistry. 2004;43:13175-84 pubmed
    Na(+)/glucose cotransport by SGLT1 is a tightly coupled process that is driven by the Na(+) electrochemical gradient across the plasma membrane...
  7. Loo D, Hirayama B, Cha A, Bezanilla F, Wright E. Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter. J Gen Physiol. 2005;125:13-36 pubmed
    ..The cotransporter was expressed in Xenopus laevis oocytes, and SGLT1 charge movements were measured in the micro- to millisecond time scale using the cut-open oocyte preparation and ..
  8. Xia X, Wang G, Peng Y, Jen J. Cys351 and Cys361 of the Na+/glucose cotransporter are important for both function and cell-surface expression. Arch Biochem Biophys. 2005;438:63-9 pubmed
    ..Cys361 as novel residues critical for the function and plasma membrane targeting of the Na+/glucose transporter-1 (SGLT1)...
  9. Gagnon D, Holt A, Bourgeois F, Wallendorff B, Coady M, Lapointe J. Membrane topology of loop 13-14 of the Na+/glucose cotransporter (SGLT1): a SCAM and fluorescent labelling study. Biochim Biophys Acta. 2005;1712:173-84 pubmed
    ..of the hydrophilic loop between putative transmembrane segments XIII and XIV of the Na+/glucose cotransporter (SGLT1) was studied in Xenopus oocytes, using the substituted cysteine accessibility method (SCAM) and fluorescent ..

More Information

Publications120 found, 100 shown here

  1. Weihua Z, Tsan R, Huang W, Wu Q, Chiu C, Fidler I, et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell. 2008;13:385-93 pubmed publisher
    ..here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).
  2. Longpré J, Gagnon D, Coady M, Lapointe J. The actual ionic nature of the leak current through the Na+/glucose cotransporter SGLT1. Biophys J. 2010;98:231-9 pubmed publisher
    Expression of the Na(+)/glucose cotransporter SGLT1 in Xenopus oocytes is characterized by a phlorizin-sensitive leak current (in the absence of glucose) that was originally called a "Na(+) leak" and represents some 5-10% of ..
  3. Manzano S, Williamson G. Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol Nutr Food Res. 2010;54:1773-80 pubmed publisher
    ..Using sodium-containing (glucose transporters SGLT1 and GLUT2 both active) and sodium-free (only GLUT2 active) conditions, we show that the inhibition of GLUT2 was ..
  4. Longpré J, Lapointe J. Determination of the Na(+)/glucose cotransporter (SGLT1) turnover rate using the ion-trap technique. Biophys J. 2011;100:52-9 pubmed publisher
    The Na(+)/glucose cotransporter (SGLT1) is a membrane protein that couples the transport of two Na(+) ions and one glucose molecule using the so-called alternating access mechanism...
  5. Liao P, Liao M, Li L, Tan B, Yin Y. Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells. Toxicol Res (Camb). 2017;6:866-877 pubmed publisher
    ..genes, including B0,+ amino acid transporter (B0,+AT) and sodium-glucose transporter 1 (SGLT1) genes, showed a significant decrease (P < 0...
  6. Lang F, Stournaras C. Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth. Hormones (Athens). 2013;12:160-71 pubmed
    ..SGK1 up-regulates the Na⁺/K⁺-ATPase, a variety of carriers (e.g. NCC, NKCC, NHE1, NHE3, SGLT1, several amino acid transporters) and many ion channels (e.g...
  7. Kang H, Lim W, Lee J, Ho J, Lim E, Cho H. Germinated Waxy Black Rice Ameliorates Hyperglycemia and Dyslipidemia in Streptozotocin-Induced Diabetic Rats. Biol Pharm Bull. 2017;40:1846-1855 pubmed publisher
    ..who received GWBR supplementation exhibited decreased expression of sodium-dependent glucose transporter 1 (SGLT1) and glucose transporter (GLUT) 2 genes and proteins in the small intestine via decreases in hepatocyte nuclear ..
  8. Faseleh Jahromi M, Wesam Altaher Y, Shokryazdan P, Ebrahimi R, Ebrahimi M, Idrus Z, et al. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions. Int J Biometeorol. 2016;60:1099-110 pubmed publisher
    ..strains significantly increased the expression of the four sugar transporter genes tested (GLUT2, GLUT5, SGLT1, and SGLT4) indicating probiotic enhances the absorption of this nutrient...
  9. Satoh T, Igarashi M, Yamada S, Takahashi N, Watanabe K. Inhibitory effect of black tea and its combination with acarbose on small intestinal α-glucosidase activity. J Ethnopharmacol. 2015;161:147-55 pubmed publisher
    ..glucose transporter 2 (GLUT2) and the uptake of α-methyl-d-glucose by sodium-dependent glucose transporter 1 (SGLT1)...
  10. Niu L, Chen Q, Hua C, Geng Y, Cai L, Tao S, et al. Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats. J Anim Sci Biotechnol. 2018;9:26 pubmed publisher
    ..The expression of glucose transporter type 2 (GLUT2), sodium-glucose transporter 1 (SGLT1) and sodium-potassium ATPase (Na-K/ATPase) in the small intestine were generally increased by Dex, and <..
  11. Lee T, Chang N, Lin S. Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts. Free Radic Biol Med. 2017;104:298-310 pubmed publisher
    ..and then randomized to either saline, dapagliflozin (a specific SGLT2 inhibitor), phlorizin (a nonspecific SGLT1/2 inhibitor), dapagliflozin + S3I-201 (a STAT3 inhibitor), or phlorizin + S3I-201 for 4 weeks...
  12. Xu S, Wang D, Zhang P, Lin Y, Fang Z, Che L, et al. Oral administration of Lactococcus lactis-expressed recombinant porcine epidermal growth factor stimulates the development and promotes the health of small intestines in early-weaned piglets. J Appl Microbiol. 2015;119:225-35 pubmed publisher
    ..sucrose, aminopeptidase A, and aminopeptidase N, and the nutrient transporters sodium/glucose cotransporter 1 (SGLT1), glucose transporter 2, and peptide transporter 1 (PEPT1) as compared with the control (P < 0·05) in the ..
  13. Vallon V, Rose M, Gerasimova M, Satriano J, Platt K, Koepsell H, et al. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol. 2013;304:F156-67 pubmed publisher
    ..The absence of SGLT2 did not affect renal mRNA expression of glucose transporters SGLT1, NaGLT1, GLUT1, or GLUT2 in response to STZ...
  14. Li L, He M, Liu Y, Zhang Y. Buffering agent-induced lactose content increases via growth hormone-mediated activation of gluconeogenesis in lactating goats. Physiol Res. 2018;67:317-329 pubmed
    ..This treatment may contribute to the increase of the milk yield and lactose synthesis of lactating goats. ..
  15. Anandhan A, Lei S, Levytskyy R, Pappa A, Panayiotidis M, Cerny R, et al. Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (?-Synuclein)-Environment (Paraquat) Interactions. Mol Neurobiol. 2017;54:3825-3842 pubmed publisher
    ..uptake, and in the levels of glucose transporter type 4 (GLUT4) and Na+-glucose transporters isoform 1 (SGLT1) proteins, but only inhibition of GLUT-like transport with STF-31 or ascorbic acid reduced PQ-induced cell death...
  16. Melo I, Santos Y, Costa M, Pacheco A, Silva N, Cardoso Sousa L, et al. Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. Epilepsy Behav. 2016;61:258-268 pubmed publisher
    ..with PZN increased the severity of limbic seizures during SE and increased neurodegeneration in hippocampus 24h after SE, suggesting that SGLT1 and SGLT2 could participate in the modulation of earlier stages of epileptogenic processes.
  17. Mediavilla Bravo J. [Contributions of SGLT-2 and new drugs under investigation]. Semergen. 2014;40 Suppl 2:34-40 pubmed publisher
    ..There are 2 main cotransporters in the kidney, SGLT1 and SGLT2, which reabsorb the glucose (10% and 90%, respectively) and return it to the blood...
  18. Ghezzi C, Loo D, Wright E. Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. Diabetologia. 2018;61:2087-2097 pubmed publisher
    ..for glucose reabsorption from the glomerular filtrate in the proximal tubule: sodium-glucose cotransporters SGLT1 and SGLT2, in the apical membrane, and GLUT2, a uniporter in the basolateral membrane...
  19. Barat A, Sahoo P, Kumar R, Pande V. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comp Biochem Physiol B Biochem Mol Biol. 2016;200:54-61 pubmed publisher
    ..The slc5a1, slc5a12, slc12a3, slc13a3, slc22a13 and slc26a6 were highly expressed in kidney...
  20. Barberis A, Garbetta A, Cardinali A, Bazzu G, D Antuono I, Rocchitta G, et al. Real-time monitoring of glucose and phenols intestinal absorption through an integrated Caco-2TC7cells/biosensors telemetric device: Hypoglycemic effect of fruit phytochemicals. Biosens Bioelectron. 2017;88:159-166 pubmed publisher
    ..1%) comparable to HPLC analysis (4.8%). Phloridzin and phloretin, specific phenolic inhibitors of SGLT1 and GLUT2 glucose transporters, reduced the glucose transport of almost 10 times...
  21. França M, Mesquita F, Lopes E, Pugliesi G, Van Hoeck V, Chiaratti M, et al. Modulation of periovulatory endocrine profiles in beef cows: consequences for endometrial glucose transporters and uterine fluid glucose levels. Domest Anim Endocrinol. 2015;50:83-90 pubmed publisher
    ..No differences (P > 0.05) were detected in gene expression patterns of SLC2A1, SLC2A3, SLC2A4, SLC2A5, SLC5A1, ATP1A2, ATP1B2, and SLC37A4...
  22. Hawley S, Ford R, Smith B, Gowans G, Mancini S, Pitt R, et al. The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels. Diabetes. 2016;65:2784-94 pubmed publisher
    ..reuptake by sodium/glucose cotransporter (SGLT) 2 in the kidney, without affecting intestinal glucose uptake by SGLT1. We now report that canagliflozin also activates AMPK, an effect also seen with phloretin (the aglycone breakdown ..
  23. Lang F, Huang D, Vallon V. SGK, renal function and hypertension. J Nephrol. 2010;23 Suppl 16:S124-9 pubmed
    ..a variety of ion channels such as ENaC, TRPV5, ROMK, KCNE1/KCNQ1 and ClCKb; carriers such as NHE3, NKCC2, NCC and SGLT1; as well as the Na+/K+-ATPase...
  24. Du J, Hu C, Bai J, Peng M, Wang Q, Zhao N, et al. Intestinal Glucose Absorption Was Reduced by Vertical Sleeve Gastrectomy via Decreased Gastric Leptin Secretion. Obes Surg. 2018;28:3851-3861 pubmed publisher
    ..Decreased GLUT2 and enhanced SGLT1 were observed following VSG...
  25. Yonamine C, Pinheiro Machado E, Michalani M, Freitas H, Okamoto M, Correa Giannella M, et al. Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Nutr Metab (Lond). 2016;13:44 pubmed publisher
    ..Resveratrol did not alter the expression of the glucose transporters GLUT2 and SGLT1 in the intestine, GLUT2 and SGLT2 in kidney and GLUT4 in soleus, suggesting that fluxes of glucose in these ..
  26. Deck C, Anderson W, Conlon J, Walsh P. The activity of the rectal gland of the North Pacific spiny dogfish Squalus suckleyi is glucose dependent and stimulated by glucagon-like peptide-1. J Comp Physiol B. 2017;187:1155-1161 pubmed publisher
    ..The results showed that sglt1 mRNA is present in the gland, and there was a significant reduction in sglt1 transcript abundance 24 h post-..
  27. Andersson E, Chivukula I, Hankeova S, Sjöqvist M, Tsoi Y, Ramsköld D, et al. Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. Gastroenterology. 2018;154:1080-1095 pubmed publisher
    ..identified dysregulated genes encoding proteins enriched at the apical side of cholangiocytes, including CFTR and SLC5A1, as well as reduced expression of IGF1...
  28. Wright E. Renal Na(+)-glucose cotransporters. Am J Physiol Renal Physiol. 2001;280:F10-8 pubmed
    ..There are at least three different candidates for these human renal Na(+)-glucose cotransporters. This review will focus on the structure-function relationships of these three transporters, SGLT1, SGLT2, and SGLT3.
  29. Oguma T, Nakayama K, Kuriyama C, Matsushita Y, Yoshida K, Hikida K, et al. Intestinal Sodium Glucose Cotransporter 1 Inhibition Enhances Glucagon-Like Peptide-1 Secretion in Normal and Diabetic Rodents. J Pharmacol Exp Ther. 2015;354:279-89 pubmed publisher
    ..role in glucose absorption and incretin hormone release in the gastrointestinal tract; however, the impact of SGLT1 inhibition on plasma glucagon-like peptide-1 (GLP-1) levels in vivo is controversial...
  30. Obermeier S, Hüselweh B, Tinel H, Kinne R, Kunz C. Expression of glucose transporters in lactating human mammary gland epithelial cells. Eur J Nutr. 2000;39:194-200 pubmed
    ..Using RT-PCR, Southern and Western blotting we analyzed the expression of SGLT1 (sodium glucose cotransporter 1) und GLUT1 (sodium independent glucose transporter) in epithelial cells isolated from fresh human milk...
  31. Yin L, Menon R, Gupta R, Vaught L, Okunieff P, Vidyasagar S. Glucose enhances rotavirus enterotoxin-induced intestinal chloride secretion. Pflugers Arch. 2017;469:1093-1105 pubmed publisher
    ..Since glucose enhances intestinal chloride secretion and fails to increase sodium absorption in the presence of NSP4, glucose-based oral rehydration solutions may not be ideal for the management of rotaviral diarrhea. ..
  32. Perez M, Praena Fernández J, Felipe Abrio B, Lopez Garcia M, Lucena Cacace A, Garcia A, et al. MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival. PLoS ONE. 2013;8:e56169 pubmed publisher
    ..Because the expression of MAP17 increases reactive oxygen species (ROS) generation through SGLT1 in cancer cells, in the present work, we investigated whether MAP17 and/or SGLT1 might be markers for the activity ..
  33. Sclafani A, Koepsell H, Ackroff K. SGLT1 sugar transporter/sensor is required for post-oral glucose appetition. Am J Physiol Regul Integr Comp Physiol. 2016;310:R631-9 pubmed publisher
    Recent findings suggest that the intestinal sodium-glucose transporter 1 (SGLT1) glucose transporter and sensor mediates, in part, the appetite-stimulation actions of intragastric (IG) glucose and nonmetabolizable α-methyl-d-..
  34. Cao Y, Sun Y, Zou S, Li M, Xu X. Orally Administered Baker's Yeast ?-Glucan Promotes Glucose and Lipid Homeostasis in the Livers of Obesity and Diabetes Model Mice. J Agric Food Chem. 2017;65:9665-9674 pubmed publisher
    ..Additionally, BYG decreased glucose transporters SGLT1 and GLUT2, fat emulsification, and adipogenic genes/proteins in the intestine to decrease glucose and lipid ..
  35. Bach A, Guasch I, Elcoso G, Chaucheyras Durand F, Castex M, Fàbregas F, et al. Changes in gene expression in the rumen and colon epithelia during the dry period through lactation of dairy cows and effects of live yeast supplementation. J Dairy Sci. 2018;101:2631-2640 pubmed publisher
    ..Total RNA was extracted from rumen and colon tissues, and the expression of IL10, TNFA, TLR4, IL1B, PCNA, MKI67, SGLT1, BAX, CASP3, OCLN, CLDN4, HSPA1A, HSPB1, DEFB1, and MCT1 (the latter only in rumen samples) was quantified by ..
  36. Wells R, Pajor A, Kanai Y, Turk E, Wright E, Hediger M. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol. 1992;263:F459-65 pubmed
    We have used low-stringency screening with the human intestinal Na(+)-glucose cotransporter SGLT1 to isolate a 2,271-nucleotide cDNA (Hu14) from human kidney...
  37. Solocinski K, Richards J, All S, Cheng K, Khundmiri S, Gumz M. Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells. Am J Physiol Renal Physiol. 2015;309:F933-42 pubmed publisher
    ..The goal of the present study was to determine if Per1 regulates the expression of NHE3, SGLT1, and SGLT2 in the kidney...
  38. Baud G, Raverdy V, Bonner C, Daoudi M, Caiazzo R, Pattou F. Sodium glucose transport modulation in type 2 diabetes and gastric bypass surgery. Surg Obes Relat Dis. 2016;12:1206-12 pubmed publisher
    ..Sodium-glucose cotransporter 1 (SGLT1) is essential for intestinal glucose absorption from the lumen into enterocytes, whereas glucose reabsorption by ..
  39. Dai L, Hu W, Xia L, Xia M, Yang Q. Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake. PLoS ONE. 2016;11:e0165585 pubmed publisher
    ..role in glucose absorption via the apical and basolateral transporters Na+-dependent glucose transporter 1 (SGLT1) and facilitative glucose transporter 2 (GLUT2), respectively...
  40. Jeukendrup A. Training the Gut for Athletes. Sports Med. 2017;47:101-110 pubmed publisher
    ..For example, a high-carbohydrate diet will increase the density of sodium-dependent glucose-1 (SGLT1) transporters in the intestine as well as the activity of the transporter, allowing greater carbohydrate ..
  41. Dengler F, Rackwitz R, Pfannkuche H, Gäbel G. Glucose transport across lagomorph jejunum epithelium is modulated by AMP-activated protein kinase (AMPK) under hypoxia. J Appl Physiol (1985). 2017;:jap.00436.2017 pubmed publisher
    ..Hypoxia was simulated by gassing with 1% O2 instead of 100% O2 The activity of SGLT1 (sodium-coupled glucose transporter 1) was assessed by measuring the increase of short circuit current (Isc) after ..
  42. Zhang D, Lei T, Lv C, Zhao H, Xu H, Lu J. Pharmacokinetic studies of active triterpenoid saponins and the total secondary saponin from Anemone raddeana Regel. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1044-1045:54-62 pubmed publisher
    ..Interestingly, the uptake ratio of them declined significantly when treated with phloridzin (SGLT1 inhibitor)...
  43. Li H, You L, Xie J, Pan H, Han W. The roles of subcellularly located EGFR in autophagy. Cell Signal. 2017;35:223-230 pubmed publisher
    ..The kinase-independent function of pcEGFR inhibits autophagy by maintaining SLC5A1-regulated intracellular glucose level...
  44. Ikari A, Nakano M, Kawano K, Suketa Y. Up-regulation of sodium-dependent glucose transporter by interaction with heat shock protein 70. J Biol Chem. 2002;277:33338-43 pubmed
    ..We investigated whether sodium-dependent glucose transporter (SGLT1) interacts with Hsp70 to increase SGLT1 activity...
  45. Yu L, Flynn A, Turner J, Buret A. SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: a novel cellular rescue mechanism?. FASEB J. 2005;19:1822-35 pubmed
    ..The understanding of this novel glucose-mediated rescue mechanism may lead to therapeutic interventions for various enteric diseases. ..
  46. Patel C, Douard V, Yu S, Gao N, Ferraris R. Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption. FASEB J. 2015;29:4046-58 pubmed publisher
    ..GLUTs 7, 8, and 12 whose expression, and that of GLUT 2 and the sodium-dependent glucose transporter protein 1 (SGLT1), was not regulated by luminal fructose...
  47. Madunić I, Breljak D, Karaica D, Koepsell H, Sabolic I. Expression profiling and immunolocalization of Na+-D-glucose-cotransporter 1 in mice employing knockout mice as specificity control indicate novel locations and differences between mice and rats. Pflugers Arch. 2017;469:1545-1565 pubmed publisher
    The expression and localization of sodium-D-glucose cotransporter SGLT1 (SLC5A1), which is involved in small intestinal glucose absorption and renal glucose reabsorption, is of high biomedical relevance because SGLT1 inhibitors are ..
  48. Martin M, Wang J, Solorzano Vargas R, Lam J, Turk E, Wright E. Regulation of the human Na(+)-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1. Am J Physiol Gastrointest Liver Physiol. 2000;278:G591-603 pubmed
    The Na(+)-glucose cotransporter (SGLT1) is expressed primarily by small intestinal epithelial cells and transports the monosaccharides glucose and galactose across the apical membrane...
  49. Alzaid F, Cheung H, Preedy V, Sharp P. Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS ONE. 2013;8:e78932 pubmed publisher
    ..In longer-term studies, SGLT1 mRNA and GLUT2 mRNA expression were reduced significantly...
  50. Ghezzi C, Yu A, Hirayama B, Kepe V, Liu J, Scafoglio C, et al. Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule. J Am Soc Nephrol. 2017;28:802-810 pubmed publisher
    ..We detected prominent binding of intravenously injected F-Dapa in the kidney cortexes of rats and wild-type and Sglt1-knockout mice but not Sglt2-knockout mice, and injection of SGLT2 inhibitors prevented this binding...
  51. Sharma P, Khairnar V, Madunić I, Singh Y, Pandyra A, Salker M, et al. SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice. Cell Physiol Biochem. 2017;42:1358-1365 pubmed publisher
    ..Genetic knockout of SGLT1 (Slc5a1-/- mice) significantly compromised bacterial clearance following Listeria monocytogenes infection with ..
  52. Arena M, Govers C, Lotti C, Ricciardi L, Wichers H, Mes J. The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2. Molecules. 2018;23: pubmed publisher
    ..genes involved in cholesterol/sterol biosynthesis (LDLR), lipid metabolism (NR2F2), glucose and amino acid uptake (SGLT1, PAT1), cell cycle (PCNA, CDKN1A), apoptosis (CASP-3, BMF, KLF6), tight junctions (CLDN4, OCLN2) and cytokine-..
  53. Wang C, Chang W, Huang Y, Chou F, Chan F, Su S, et al. An essential role of cAMP response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake. Int J Biochem Cell Biol. 2015;64:239-51 pubmed publisher
    The sodium/glucose cotransporter 1 (SGLT1) is responsible for glucose uptake in intestinal epithelial cells...
  54. Turner J, Black E. NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia. Am J Physiol Cell Physiol. 2001;281:C1533-41 pubmed
    ..occurred in parallel with glucose uptake and required expression of the intestinal Na(+)-glucose cotransporter SGLT1. S-3226, a preferential inhibitor of Na(+)/H(+) exchanger (NHE) isoform 3 (NHE3), prevented cytoplasmic ..
  55. Jiang L, David E, Espina N, Ferraris R. GLUT-5 expression in neonatal rats: crypt-villus location and age-dependent regulation. Am J Physiol Gastrointest Liver Physiol. 2001;281:G666-74 pubmed
    ..fructose uptake rate and moderately increased GLUT-5 mRNA abundance but had no effect on glucose uptake rates and SGLT1 mRNA abundance...
  56. Kianifar H, Talebi S, Tavakkol Afshari J, Esmaili M, Davachi B, Brook A. D28G mutation in congenital glucose-galactose malabsorption. Arch Iran Med. 2007;10:514-8 pubmed
    ..To the best of our knowledge this is the first report of D28G mutation in Iran. Moreover, this simple typical PCR-Restriction Fragment Length Polymorphism method, allows immediate identification of D28G mutation. ..
  57. Zeuthen T, Gorraitz E, Her K, Wright E, Loo D. Structural and functional significance of water permeation through cotransporters. Proc Natl Acad Sci U S A. 2016;113:E6887-E6894 pubmed
    ..Here, we map the pathway for water and urea through the intestinal sodium/glucose cotransporter SGLT1. Molecular dynamics simulations using the atomic structure of the bacterial transporter vSGLT suggest that water ..
  58. Klinger S, Breves G. Resveratrol Inhibits Porcine Intestinal Glucose and Alanine Transport: Potential Roles of Na?/K?-ATPase Activity, Protein Kinase A, AMP-Activated Protein Kinase and the Association of Selected Nutrient Transport Proteins with Detergent Resistant Memb. Nutrients. 2018;10: pubmed publisher
    ..The phosphorylation of sodium-glucose-linked transporter 1 (SGLT1), AMP-activated protein kinase (AMPK), protein kinase A substrates (PKA-S) and liver kinase B1 (LKB1) increased ..
  59. Davidson N, Hausman A, Ifkovits C, Buse J, Gould G, Burant C, et al. Human intestinal glucose transporter expression and localization of GLUT5. Am J Physiol. 1992;262:C795-800 pubmed
    ..The abundance of mRNAs encoding the Na(+)-glucose cotransporter isoform SGLT1 and the facilitative glucose transporter isoforms GLUT2 and GLUT5 is developmentally modulated with highest levels ..
  60. Veyhl Wichmann M, Friedrich A, Vernaleken A, Singh S, Kipp H, Gorboulev V, et al. Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption. Mol Pharmacol. 2016;89:118-32 pubmed publisher
    ..a 67-kDa protein named RS1 that has been shown to induce downregulation of the sodium-D-glucose cotransporter 1 (SGLT1) and of the concentrative nucleoside transporter 1 (CNT1) in the plasma membrane by blocking exocytosis at the ..
  61. Vallon V, Thomson S. Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia. 2017;60:215-225 pubmed publisher
    ..of SGLT2, the renal reabsorptive capacity for glucose declines to ∼80 g/day (the residual capacity of SGLT1), i.e. the safety valve opens at a lower threshold, which makes it relevant to glucose homeostasis from day-to-day...
  62. DeFronzo R, Norton L, Abdul Ghani M. Renal, metabolic and cardiovascular considerations of SGLT2 inhibition. Nat Rev Nephrol. 2017;13:11-26 pubmed publisher
    ..glucose through gluconeogenesis, and by reabsorbing all filtered glucose through the sodium-glucose cotransporters SGLT1 and SGLT2 located in the proximal tubule...
  63. Lam J, Martin M, Turk E, Hirayama B, Bosshard N, Steinmann B, et al. Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects. Biochim Biophys Acta. 1999;1453:297-303 pubmed
    ..malabsorption (GGM) is an autosomal recessive disorder caused by defects in the Na+/glucose cotransporter (SGLT1). Neonates present with severe diarrhea while on any diet containing glucose and/or galactose [1]...
  64. Canani R, De Marco G, Passariello A, Buccigrossi V, Ruotolo S, Bracale I, et al. Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. AIDS. 2006;20:5-10 pubmed
    ..Tat acutely impairs intestinal glucose absorption through SGLT-1 missorting. This result indicates that Tat is directly involved in AIDS-associated intestinal dysfunction. ..
  65. Vallon V. Molecular determinants of renal glucose reabsorption. Focus on "Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2". Am J Physiol Cell Physiol. 2011;300:C6-8 pubmed publisher
  66. Lambert R, Srodulski S, Peng X, Margulies K, Despa F, Despa S. Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport. J Am Heart Assoc. 2015;4:e002183 pubmed publisher
    ..Myocyte Na(+)-glucose cotransport is enhanced in T2D, which increases Na(+) influx and causes Na(+) overload. Higher [Na(+)]i may contribute to arrhythmogenesis and oxidative stress in diabetic hearts. ..
  67. Kottra G, Daniel H. Flavonoid glycosides are not transported by the human Na+/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake. J Pharmacol Exp Ther. 2007;322:829-35 pubmed
    ..remained unchanged when the attached glucose was replaced by galactose, suggesting that these residues may bind to SGLT1. Kinetic analysis by Dixon plots revealed inhibition of competitive type with high affinities, particularly when ..
  68. Castaneda F, Burse A, Boland W, Kinne R. Thioglycosides as inhibitors of hSGLT1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes. Int J Med Sci. 2007;4:131-9 pubmed
    ..Inhibition of glucose reabsorption in the kidney, mediated by SGLT1 or SGLT2, represents a promising therapeutic approach...
  69. Weinglass A, Swensen A, Liu J, Schmalhofer W, Thomas A, Williams B, et al. A high-capacity membrane potential FRET-based assay for the sodium-coupled glucose co-transporter SGLT1. Assay Drug Dev Technol. 2008;6:255-62 pubmed publisher
    ..Using human SGLT1 (hSGLT1) as a paradigm, we developed a functional assay that should be adaptable to ultra-high-throughput ..
  70. Casneuf V, Fonteyne P, Van Damme N, Demetter P, Pauwels P, de Hemptinne B, et al. Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival. Cancer Invest. 2008;26:852-9 pubmed publisher
    ..It is not known whether Sodium dependent GLucose Transporter 1 (SGLT1) is up-regulated in pancreatic cancer...
  71. Janku F, Huang H, Angelo L, Kurzrock R. A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal. Oncotarget. 2013;4:463-73 pubmed
    ..EGFR kinase-independent function maintains intracellular glucose levels via sodium glucose transporter protein 1 (SGLT1) and supports cell survival. It is plausible that this phenomenon can apply to other receptor tyrosine kinases...
  72. Raja M, Kinne R. Identification of phlorizin binding domains in sodium-glucose cotransporter family: SGLT1 as a unique model system. Biochimie. 2015;115:187-93 pubmed publisher
    The sodium glucose cotransporter SGLT1 expressed mainly in the intestine and kidney has been explored extensively for understanding the mechanism of sugar cotransport and its inhibition by a classical competitive inhibitor, phlorizin (Pz)..
  73. Reyer H, Zentek J, Männer K, Youssef I, Aumiller T, Weghuber J, et al. Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers. J Agric Food Chem. 2017;65:6821-6830 pubmed publisher
    ..Complementary analyses in Caco-2 showed a significant increase in transporter recruitment to the membrane (SGLT1 and PEPT1) after addition of essential oils and saponins...
  74. Wang B, An N, Shaikh A, Wang H, Xiao L, Liu H, et al. Hyperosmolarity evokes histamine release from ileum mucosa by stimulating a cholinergic pathway. Biochem Biophys Res Commun. 2017;493:1037-1042 pubmed publisher
    ..In contrast, it was not blocked by phlorizin, a Na+-glucose cotransporter SGLT1 inhibitor...
  75. Bauer P, Duca F, Waise T, Rasmussen B, Abraham M, Dranse H, et al. Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway. Cell Metab. 2018;27:101-117.e5 pubmed publisher
    ..In parallel, metformin regulates upper small intestinal sodium glucose cotransporter-1 (SGLT1), but whether changes of the microbiota or SGLT1-dependent pathways in the upper small intestine mediate metformin ..
  76. Jin X, Yi L, Chen M, Chen C, Chang H, Zhang T, et al. Delphinidin-3-glucoside protects against oxidized low-density lipoprotein-induced mitochondrial dysfunction in vascular endothelial cells via the sodium-dependent glucose transporter SGLT1. PLoS ONE. 2013;8:e68617 pubmed publisher
    ..cells in a temperature, concentration, and time-dependent manner via the sodium-dependent glucose transporter (SGLT1). Suppression of SGLT1 by its substrate glucose, its inhibitor phlorizin or SGLT1 siRNA blocked Dp transportation...
  77. Chu K, Yao C, Song J, Chen C, Yeh T, Hsieh T, et al. N-Indolylglycosides bearing modifications at the glucose C6-position as sodium-dependent glucose co-transporter 2 inhibitors. Bioorg Med Chem. 2016;24:2242-50 pubmed publisher
    ..derivatives 6a and 6o as potent SGLT2 inhibitors, which were further tested for inhibitory activity against SGLT1. The data obtained indicated that 6a and 6o are mildly to moderately selective for SGLT2 over SGLT1...
  78. Fiorentino T, Suraci E, Arcidiacono G, Cimellaro A, Mignogna C, Presta I, et al. Duodenal Sodium/Glucose Cotransporter 1 Expression Under Fasting Conditions Is Associated With Postload Hyperglycemia. J Clin Endocrinol Metab. 2017;102:3979-3989 pubmed publisher
    ..Duodenal SGLT-1 expression is increased in individuals with 1-hour postload hyperglycemia or IGT, as well as in subjects with T2DM, and it positively correlates with early postload glucose excursion. ..
  79. Pedder C, Ford D, Hesketh J. Targeting of transcripts encoding membrane proteins in polarized epithelia: RNA-protein binding studies of the SGLT1 3'-UTR. Biochem Soc Trans. 2008;36:525-7 pubmed publisher
    ..In human epithelial cells, the mRNA coding for SGLT1 (sodium-glucose co-transporter 1), an apical membrane protein, has been shown to be localized apically in ..
  80. Leiprecht N, Munoz C, Alesutan I, Siraskar G, Sopjani M, F ller M, et al. Regulation of Na(+)-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein. Biochem Biophys Res Commun. 2011;404:695-700 pubmed publisher
    ..They accomplish cellular glucose uptake in part through Na(+)-coupled glucose transport mediated by SGLT1 (SLC5A1)...
  81. Bhavsar S, Singh Y, Sharma P, Khairnar V, Hosseinzadeh Z, Zhang S, et al. Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes. Cell Physiol Biochem. 2016;39:1209-28 pubmed publisher
    ..In contrast to GLUT isoforms, Na+-coupled glucose-carrier SGLT1 accumulates glucose against glucose gradients and is effective at low extracellular glucose concentrations...
  82. Kasahara M, Maeda M, Hayashi S, Mori Y, Abe T. A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein. Biochim Biophys Acta. 2001;1536:141-7 pubmed
    The Na(+)/glucose cotransporter gene SGLT1 was analyzed in a Japanese patient with congenital glucose-galactose malabsorption...
  83. Kipp H, Khoursandi S, Scharlau D, Kinne R. More than apical: Distribution of SGLT1 in Caco-2 cells. Am J Physiol Cell Physiol. 2003;285:C737-49 pubmed
    We investigated the distribution of the endogenous sodium-d-glucose cotransporter (SGLT1) in polarized Caco-2 cells, a model for enterocytes...
  84. Jiang X, Loo D, Hirayama B, Wright E. The importance of being aromatic: ? interactions in sodium symporters. Biochemistry. 2012;51:9480-7 pubmed publisher
    ..In SLC5 symporters, three aromatic residues in TM6 (SGLT1 W289, Y290, and W291) are conserved in only those transporting sugars and inositols...
  85. Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, et al. Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2. J Pharmacol Exp Ther. 2016;358:94-102 pubmed publisher
    ..A characteristic of canagliflozin is its modest SGLT1 inhibitory action in the intestine at clinical dosage...
  86. Gorraitz E, Hirayama B, Paz A, Wright E, Loo D. Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. Proc Natl Acad Sci U S A. 2017;114:E9980-E9988 pubmed publisher
    ..The time courses of fluorescence changes (milliseconds) were close to the SGLT1 capacitive charge movements...
  87. Almgren P, Lindqvist A, Krus U, Hakaste L, Ottosson Laakso E, Asplund O, et al. Genetic determinants of circulating GIP and GLP-1 concentrations. JCI Insight. 2017;2: pubmed publisher
    ..identified 6 genome-wide significant functional loci associated with plasma incretin concentrations in or near the SLC5A1 (encoding SGLT1), GIPR, ABO, GLP2R, F13A1, and HOXD1 genes and studied the effect of these variants on mRNA ..
  88. Rendell M. Efficacy and safety of sotagliflozin in treating diabetes type 1. Expert Opin Pharmacother. 2017;: pubmed publisher
    Sotagliflozin is the first dual SGLT1/SGLT2 inhibitor developed for use in diabetes...
  89. Nasrallah R, Zimpelmann J, Eckert D, Ghossein J, Geddes S, Beique J, et al. PGE2 EP1 receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct. Lab Invest. 2017;: pubmed publisher
    ..Microdissected proximal tubule sglt1, NHE3, and AQP1 were increased in HtnEP1-/-, but sglt2 was increased in EP1-/- mice...
  90. Anderson N, Anderson N. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002;1:845-67 pubmed
  91. Palazzo M, Gariboldi S, Zanobbio L, Selleri S, Dusio G, Mauro V, et al. Sodium-dependent glucose transporter-1 as a novel immunological player in the intestinal mucosa. J Immunol. 2008;181:3126-36 pubmed
  92. Lai B, Xiao Y, Pu H, Cao Q, Jing H, Liu X. Overexpression of SGLT1 is correlated with tumor development and poor prognosis of ovarian carcinoma. Arch Gynecol Obstet. 2012;285:1455-61 pubmed publisher
    ..However, the expression status of Sodium dependent Glucose Transporter 1 (SGLT1) in ovarian carcinoma has not been investigated...