Gene Symbol: SLC48A1
Description: solute carrier family 48 member 1
Alias: HRG-1, HRG1, hHRG-1, heme transporter HRG1, heme-responsive gene 1 protein homolog, solute carrier family 48 (heme transporter), member 1
Sohoni S, Ghosh P, Wang T, Kalainayakan S, Vidal C, Dey S, et al
. Elevated heme synthesis and uptake underpin intensified oxidative metabolism and tumorigenic functions in non-small cell lung cancer cells. Cancer Res. 2019;: pubmed publisher
..heme synthesis or uptake by overexpressing either the rate-limiting heme synthesis enzyme ALAS1 or uptake protein SLC48A1, respectively. These cells exhibited enhanced migration and invasion and accelerated tumor growth in mice...
Zhang J, Chambers I, Yun S, Phillips J, Krause M, Hamza I. Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney. PLoS Genet. 2018;14:e1007665 pubmed publisher
..Studies in cultured cells have ascribed a role for HRG1/SLC48A1 in heme-iron transport but the in vivo function of this heme transporter is unclear...
Renberg R, Yuan X, Samuel T, Miguel D, Hamza I, Andrews N, et al
. The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis. PLoS Negl Trop Dis. 2015;9:e0003804 pubmed publisher
..Since LHR1 is significantly divergent from the human heme transporter HRG1, our findings lay the groundwork for selective targeting of LHR1 by small molecule antagonists.
Taye M, Kim J, Yoon S, Lee W, Hanotte O, Dessie T, et al
. Whole genome scan reveals the genetic signature of African Ankole cattle breed and potential for higher quality beef. BMC Genet. 2017;18:11 pubmed publisher
..MB and SLC48A1 affect meat color...
White C, Yuan X, Schmidt P, Bresciani E, Samuel T, Campagna D, et al
. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013;17:261-70 pubmed publisher
..Here, we show that the mammalian homolog of HRG1, a transmembrane heme permease in C...
Fogarty F, O Keeffe J, Zhadanov A, Papkovsky D, Ayllon V, O CONNOR R. HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase. Oncogene. 2014;33:4653-63 pubmed publisher
..Thus, HRG-1 may represent a novel target for selectively disrupting V-ATPase activity and the metastatic potential of cancer cells. ..
Rajagopal A, Rao A, Amigo J, Tian M, Upadhyay S, Hall C, et al
. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature. 2008;453:1127-31 pubmed publisher
..Thus, uncovering the mechanisms of haem transport in C. elegans may provide insights into human disorders of haem metabolism and reveal new drug targets for developing anthelminthics to combat worm infestations. ..
O Callaghan K, Ayllon V, O Keeffe J, Wang Y, Cox O, Loughran G, et al
. Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking. J Biol Chem. 2010;285:381-91 pubmed publisher
..Our findings indicate that HRG-1 regulates V-ATPase activity, which is essential for endosomal acidification, heme binding, and receptor trafficking in mammalian cells. Thus, HRG-1 may facilitate tumor growth and cancer progression. ..
Yuan X, Protchenko O, Philpott C, Hamza I. Topologically conserved residues direct heme transport in HRG-1-related proteins. J Biol Chem. 2012;287:4914-24 pubmed publisher
..These findings may provide a framework for understanding the structural basis of heme transport in eukaryotes and human parasites, which rely on host heme for survival. ..