SLC47A1

Summary

Gene Symbol: SLC47A1
Description: solute carrier family 47 member 1
Alias: MATE1, multidrug and toxin extrusion protein 1, MATE-1, hMATE-1, multidrug and toxin extrusion 1, solute carrier family 47 (multidrug and toxin extrusion), member 1
Species: human
Products:     SLC47A1

Top Publications

  1. Tanihara Y, Masuda S, Sato T, Katsura T, Ogawa O, Inui K. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007;74:359-71 pubmed
    ..These results suggest that hMATE1 and hMATE2-K function together as a detoxication system, by mediating the tubular secretion of intracellular ionic compounds across the brush-border membranes of the kidney. ..
  2. Kajiwara M, Terada T, Asaka J, Ogasawara K, Katsura T, Ogawa O, et al. Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1. Am J Physiol Renal Physiol. 2007;293:F1564-70 pubmed
    A H+/organic cation antiporter (multidrug and toxin extrusion 1: MATE1/SLC47A1) plays important roles in the tubular secretion of various clinically important cationic drugs such as cimetidine...
  3. Matsumoto T, Kanamoto T, Otsuka M, Omote H, Moriyama Y. Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter. Am J Physiol Cell Physiol. 2008;294:C1074-8 pubmed publisher
    ..These results suggest that all of these glutamate residues are involved in binding and/or transport of TEA and cimetidine but that their individual roles are different. ..
  4. Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A. 2005;102:17923-8 pubmed
    ..However, the protein transporters involved in the final excretion step are poorly understood. Here, we show that MATE1, a human and mouse orthologue of the multidrug and toxin extrusion family conferring multidrug resistance on ..
  5. Chen Y, Teranishi K, Li S, Yee S, Hesselson S, Stryke D, et al. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J. 2009;9:127-36 pubmed publisher
    hMATE1 (human multidrug and toxin compound extrusion-1; encoded by SLC47A1) is thought to have an important function in the renal and hepatic elimination of drugs, endogenous compounds and environmental toxins...
  6. Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, et al. Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidi. Pharmacol Res Perspect. 2017;5: pubmed publisher
    ..Calculated theoretical fold-increases in metformin exposure confirmed solitary inhibition of renal MATE1 to be the likely mechanism underlying the observed exposure changes in clinical DDIs...
  7. Thevenod F, Fels J, Lee W, Zarbock R. Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts. Biometals. 2019;: pubmed publisher
    ..Cd2+ flux occurs through the influx carrier OCT2/SLC22A2, efflux MATE proteins SLC47A1/A2, the efflux ATPase ABCB1, and RME of Cd2+-metallothionein by the receptor megalin (low density ..
  8. Takano H, Ito S, Zhang X, Ito H, Zhang M, Suzuki H, et al. Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist. J Pharm Sci. 2017;106:2558-2565 pubmed publisher
    ..Oct1/2 double knockout mice and wild-type mice received Mate1 inhibitors (pyrimethamine/cimetidine) manifested reduced renal clearance of sulpiride, accompanied with its ..
  9. Li L, Weng Y, Wang W, Bai M, Lei H, Zhou H, et al. Multiple organic cation transporters contribute to the renal transport of sulpiride. Biopharm Drug Dispos. 2017;38:526-534 pubmed publisher
    ..The results implied that OCTN1, OCTN2, OCT2, MATE1 and MATE2-K probably contributed to the renal transfer of sulpiride, in which OCT2 mediated the uptake of ..

More Information

Publications140 found, 100 shown here

  1. Schioth H, Boström A, Murphy S, Erhart W, Hampe J, Moylan C, et al. A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease. BMC Genomics. 2016;17:462 pubmed publisher
    ..e. genes such as CYP27A1, OST?, and SLC27A5 (BA homeostasis), and SLCO2B1, SLC47A1, and several UGT and CYP genes (DM) to be NAFLD dependently modulated...
  2. Abdussalam A, Elshenawy O, Bin Jardan Y, El Kadi A, Brocks D. The Obesogenic Potency of Various High-Caloric Diet Compositions in Male Rats, and Their Effects on Expression of Liver and Kidney Proteins Involved in Drug Elimination. J Pharm Sci. 2017;106:1650-1658 pubmed publisher
    ..For transporters, decreases in expressions of Oct1/2 and Mate1 were seen, with no change in Mdr1...
  3. Jensen J, Sundelin E, Jakobsen S, Gormsen L, Munk O, Frøkiær J, et al. [11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency. Diabetes. 2016;65:1724-30 pubmed publisher
    ..In contrast, inhibition of MATE1 with pyrimethamine caused accumulation of metformin in the liver but did not affect distribution in the small ..
  4. Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y. Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells. J Pharm Sci. 2017;106:2576-2582 pubmed publisher
    ..and by substrates of H+/OC antiporter, but not by substrates or inhibitors of OCTs, OCTNs, PMAT, and MATE1, which are known organic cation transporters...
  5. Tong Z, Yerramilli U, Surapaneni S, Kumar G. The interactions of lenalidomide with human uptake and efflux transporters and UDP-glucuronosyltransferase 1A1: lack of potential for drug-drug interactions. Cancer Chemother Pharmacol. 2014;73:869-74 pubmed publisher
    ..OCT1 and OCT2), human organic cation transporter novel 1 and 2 (OCTN1 and OCTN2), multidrug and toxin extrusion (MATE1) and organic anion transporting polypeptide (OATP1B1)...
  6. Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, et al. MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..drug transporters, we revealed rilpivirine as a potent inhibitor of MDR1 and BCRP, but not MRP2, OCT1, OCT2, or MATE1. Subsequent transport experiments across monolayers of MDCKII-MDR1, MDCKII-BCRP, and Caco-2 cells demonstrated ..
  7. Shen H, Nelson D, Oliveira R, Zhang Y, McNaney C, Gu X, et al. Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys. Drug Metab Dispos. 2018;46:178-188 pubmed publisher
    ..demonstrated that PDA and HVA are substrates for human OAT1, OAT3, OAT2 (HVA), and OAT4 (PDA), but not OCT2, MATE1, MATE2K, OATP1B1, OATP1B3, and sodium taurocholate cotransporting polypeptide...
  8. Wen J, Zeng M, Shu Y, Guo D, Sun Y, Guo Z, et al. Aging increases the susceptibility of cisplatin-induced nephrotoxicity. Age (Dordr). 2015;37:112 pubmed publisher
    ..old mice accumulated more CDDP in kidney than young mice, and the protein level of CDDP efflux transporter, MATE1, in aged mice kidney was 35% of that in young mice...
  9. Shen H, Liu T, Morse B, Zhao Y, Zhang Y, Qiu X, et al. Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression. Drug Metab Dispos. 2015;43:984-93 pubmed publisher
    ..OAT2 more potently than other known creatinine transporters, OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2K (IC50: 1.3 µM vs. > 100 µM and 2.1 µM vs...
  10. Mathialagan S, Rodrigues A, Feng B. Evaluation of Renal Transporter Inhibition Using Creatinine as a Substrate In Vitro to Assess the Clinical Risk of Elevated Serum Creatinine. J Pharm Sci. 2017;106:2535-2541 pubmed publisher
    ..including organic cation transporter 2, organic anion transporter 2, and 2 forms of multidrug and toxin extrusion (MATE1 and MATE2K), were assessed in transporter-transfected cell lines using creatinine as a probe substrate...
  11. Pattaro C, Kottgen A, Teumer A, Garnaas M, Böger C, Fuchsberger C, et al. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet. 2012;8:e1002584 pubmed publisher
    ..with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80...
  12. Suhy A, Webb A, Papp A, Geier E, Sadee W. Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq. Eur J Pharm Sci. 2017;103:47-51 pubmed publisher
    ..001). RNAseq confirms a number of transporters highly enriched in BMECs (e.g., ABCB1, ABCG2, SLCO2B1, and SLC47A1), but also detects novel BMEC transporters...
  13. Santoro A, Stage T, Struchiner C, Christensen M, Brosen K, Suarez Kurtz G. Limited sampling strategy for determining metformin area under the plasma concentration-time curve. Br J Clin Pharmacol. 2016;82:1002-10 pubmed publisher
    ..976). The LSS model reproduced previously reported results for effects of polymorphisms in OCT2 and MATE1 genes on AUC(0,24 h) and renal clearance of metformin...
  14. Yu H, You X, Li J, Liu H, Meng Z, Xiao L, et al. Genome-Wide Mapping of Growth-Related Quantitative Trait Loci in Orange-Spotted Grouper (Epinephelus coioides) Using Double Digest Restriction-Site Associated DNA Sequencing (ddRADseq). Int J Mol Sci. 2016;17:501 pubmed publisher
    ..genes (fez2, alg3, ece2, arvcf, sla27a4, sgk223, camk2, prrc2b, mchr1, sardh, pappa, syk, tert, wdrcp91, ftz-f1, mate1 and notch1) including three (tert, ftz-f1 and notch1) that have been reported to be involved in fish growth...
  15. Dave R, Morris M. Quantitative structure-pharmacokinetic relationships for the prediction of renal clearance in humans. Drug Metab Dispos. 2015;43:73-81 pubmed publisher
    ..81), OCT2 (Q(2) = 0.85), MRP2/4 (Q(2) = 0.78), P-gp (Q(2) = 0.71), and MATE1/2K (Q(2) = 0.81)...
  16. Wang M, Qi H, Li J, Xu Y, Zhang H. Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. Food Chem Toxicol. 2015;86:217-24 pubmed publisher
    ..Results showed that SVG was not a substrate of efflux transporters BCRP, MRP2, MATE1 or P-gp...
  17. Tian M, Nie Q, Li Z, Zhang J, Liu Y, Long Y, et al. Transcriptomic analysis reveals overdominance playing a critical role in nicotine heterosis in Nicotiana tabacum L. BMC Plant Biol. 2018;18:48 pubmed publisher
    ..participating in nicotine anabolism (ADC, PMT, MPO, QPT, AO, QS, QPT, A622, BBLs) and nicotine transport (JAT2, MATE1 and 2, NUP1 and 2) showed an upregulated expression in the hybrid, a majority of which demonstrated an ..
  18. Hanna I, Alexander N, Crouthamel M, Davis J, Natrillo A, Tran P, et al. Transport properties of valsartan, sacubitril and its active metabolite (LBQ657) as determinants of disposition. Xenobiotica. 2018;48:300-313 pubmed publisher
    ..5.?None of the compounds inhibited OCT1/OCT2, MATE1/MATE2-K, P-gp, or BCRP...
  19. Martovetsky G, Tee J, Nigam S. Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters. Mol Pharmacol. 2013;84:808-23 pubmed publisher
    ..transporters and organic anion transporters Slc22a1 (Oct1), Slc22a2 (Oct2), Slc22a6 (Oat1), Slc22a8 (Oat3), and Slc47a1 (Mate1)...
  20. Kito T, Ito S, Mizuno T, Maeda K, Kusuhara H. Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney. Drug Metab Pharmacokinet. 2019;34:87-94 pubmed publisher
    The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic drug interactions with ..
  21. Ceckova M, Reznicek J, Deutsch B, Fromm M, Staud F. Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate). PLoS ONE. 2018;13:e0202706 pubmed publisher
    ..Accumulation and transport assays showed that efavirenz inhibits the uptake of metformin by OCT1-, OCT2- and MATE1-expressing MDCK cells and reduces transcellular transport of lamivudine across OCT1/OCT2- and MATE1-expressing ..
  22. Zhu P, Ye Z, Guo D, Xiong Z, Huang S, Guo J, et al. Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2). Pharm Res. 2018;35:243 pubmed publisher
    ..morphine in the clinic were assessed in human embryonic kidney 293 (HEK293) cells stably expressing OCT1, OCT2 and MATE1. The in vivo interaction between morphine and the select irinotecan was determined by comparing the disposition of ..
  23. Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I. Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy. J Neurochem. 2019;148:373-385 pubmed publisher
    ..Octn1/2- and Mate1-expressing cells showed the intracellular accumulation of oxaliplatin...
  24. Shi R, Xu Z, Xu X, Jin J, Zhao Y, Wang T, et al. Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine. Eur J Pharm Sci. 2019;127:282-290 pubmed publisher
    ..cation transporter 1 (MDCK-rOCT1), MDCK-rat organic cation transporter 2 (MDCK-rOCT2), and MDCK-rat multidrug and toxin extrusion 1 (MDCK-rMATE1) cells, berberine significantly inhibited metformin transport mediated by OCT1, OCT2, ..
  25. Li L, Tu M, Yang X, Sun S, Wu X, Zhou H, et al. The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride-induced hepatocellular toxicity. Drug Metab Dispos. 2014;42:1227-34 pubmed publisher
    ..organic cation transporters 1 and 3 (OCT1 and OCT3) might mediate the influx of NC into hepatocytes, multidrug and toxin extrusion 1 (MATE1) probably mediates the efflux of NC from hepatocytes, while cytochrome P450 (P450) enzymes ..
  26. Clarke J, Dzierlenga A, Nelson N, Li H, Werts S, Goedken M, et al. Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis. Diabetes. 2015;64:3305-13 pubmed publisher
    ..is almost exclusively eliminated through the kidney primarily through active secretion mediated by Oct1, Oct2, and Mate1. The purpose of this study was to determine how NASH affects kidney transporter expression and metformin ..
  27. Zhang Y, Warren M, Zhang X, Diamond S, Williams B, Punwani N, et al. Impact on creatinine renal clearance by the interplay of multiple renal transporters: a case study with INCB039110. Drug Metab Dispos. 2015;43:485-9 pubmed publisher
    ..individual or multiple transporters were used, including a novel quintuple-transporter model OAT2/OCT2/OCT3/MATE1/MATE2-K...
  28. Knop J, Misaka S, Singer K, Hoier E, Müller F, Glaeser H, et al. Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. PLoS ONE. 2015;10:e0139370 pubmed publisher
    ..OCT1-, OCT2-, MATE1- and MATE2-K-mediated metformin uptake was significantly reduced in the presence of green tea and EGCG (P < 0...
  29. Chu X, Bleasby K, Chan G, Nunes I, Evers R. The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?. Drug Metab Dispos. 2016;44:1498-509 pubmed publisher
    ..OCT2) and the organic anion transporter 2, and effluxed into the urine by the apically localized multidrug and toxin extrusion protein 1 (MATE1) and MATE2K...
  30. Pedersen A, Stage T, Glintborg D, Andersen M, Christensen M. The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial. Basic Clin Pharmacol Toxicol. 2018;122:239-244 pubmed publisher
    ..glucose tolerance testing) and polymorphisms in OCT1 (rs12208357 and rs72552763), HNF1A (rs1169288 and rs2464196), MATE1 (rs2289669 and rs2252281), MATE2-K (rs12943590) and ATM (rs11212617) were studied in 40 women with PCOS randomized ..
  31. Berg T, Hegelund Myrback T, Ockinger J, Zhou X, Brännström M, Hagemann Jensen M, et al. Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals. Respir Res. 2018;19:68 pubmed publisher
    ..To further evaluate their potential to impact on inhaled drug disposition, the localization of MATE1, P-gp, OCTN1 and OCTN2 were investigated in human lung...
  32. Knop J, Hoier E, Ebner T, Fromm M, Müller F. Renal tubular secretion of pramipexole. Eur J Pharm Sci. 2015;79:73-8 pubmed publisher
    ..Cimetidine, a potent inhibitor of multidrug and toxin extrusion proteins 1 (MATE1) and 2-K (MATE2-K), decreases renal pramipexole clearance in humans...
  33. Gessner A, König J, Fromm M. Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO). Sci Rep. 2018;8:6659 pubmed publisher
    ..Here we investigated the potential role of multidrug and toxin extrusion protein 1 (MATE1) for translocation of TMAO across the luminal membrane of proximal tubular cells...
  34. Cheng X, Gu J, Klaassen C. Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes. Drug Metab Dispos. 2014;42:1826-33 pubmed publisher
    ..II enzymes (Ugt1a9; Gsta1/2, m3, m4, m6, t1, and t3; and Sult1a1 and 1d1), and drug transporters (Oatp1a4, Oct3, Mate1, Mdr1a, and Mrp3 and 4)...
  35. Wang L, Prasad B, Salphati L, Chu X, Gupta A, Hop C, et al. Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics. Drug Metab Dispos. 2015;43:367-74 pubmed publisher
    We quantified, by liquid chromatography tandem mass spectrometry, transporter protein expression of BSEP, MATE1, MRP3, MRP4, NTCP, and OCT1 in our human liver bank (n = 55) and determined the relationship between protein expression and ..
  36. Xiao G, Rowbottom C, Boiselle C, Gan L. Fampridine is a Substrate and Inhibitor of Human OCT2, but not of Human MATE1, or MATE2K. Pharm Res. 2018;35:159 pubmed publisher
    ..The uptake of fampridine to HEK-293 cells overexpressing human OCT2, MATE1 or MATE2K was determined in the absence and presence of Cimetidine, the prototypical inhibitor of the transporters...
  37. Harrach S, Barz V, Pap T, Pavenstadt H, Schlatter E, Edemir B, et al. Notch Signaling Activity Determines Uptake and Biological Effect of Imatinib in Systemic Sclerosis Dermal Fibroblasts. J Invest Dermatol. 2019;139:439-447 pubmed publisher
    ..transporters OCT1-3, novel organic cation transporters OCTN1/2, and the multidrug and toxin extrusion protein MATE1 are expressed in healthy dermal and SSc fibroblasts...
  38. Nieskens T, Peters J, Dabaghie D, Korte D, Jansen K, van Asbeck A, et al. Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018;46:592-599 pubmed publisher
    ..Although gene expression of cisplatin efflux transporter multidrug and toxin extrusion 1 (MATE1) was 16.2 ± 0.3-fold upregulated in ciPTEC-OAT1 and 6.1 ± 0...
  39. Omote S, Matsuoka N, Arakawa H, Nakanishi T, Tamai I. Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1. Sci Rep. 2018;8:9237 pubmed publisher
    ..is actively secreted across tubular epithelial cells via organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1)...
  40. Vidak M, Jovčevska I, Samec N, Zottel A, Liovic M, Rozman D, et al. Meta-Analysis and Experimental Validation Identified FREM2 and SPRY1 as New Glioblastoma Marker Candidates. Int J Mol Sci. 2018;19: pubmed publisher
    ..identified four new CSP-encoding candidate genes&mdash;CD276, FREM2, SPRY1, and SLC47A1&mdash;and the bioinformatic validation confirmed these findings...
  41. Follman K, Morris M. Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study. Drug Metab Dispos. 2018;46:758-769 pubmed publisher
    ..TDIs), and free fraction (fu) on PK predictions for the organic cation transporter 2/multidrug and toxin extrusion protein 1 substrate metformin in RI populations; and 2) use available in vitro data to improve predictions ..
  42. McCormick A, Swaisland H. In vitro assessment of the roles of drug transporters in the disposition and drug-drug interaction potential of olaparib. Xenobiotica. 2017;47:903-915 pubmed publisher
    ..4??M), but limited inhibition of OAT1 (13.5% at 100??M); inhibition of the renal efflux transporters MATE1 and MATE2K (IC50s 5.50??M and 47...
  43. Atilano Roque A, Aleksunes L, Joy M. Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury. Toxicol Lett. 2016;259:52-59 pubmed publisher
    ..enhanced cell viability and increased expression of detoxifying enzymes (GCLC and NQO1) and the multidrug and toxin extrusion protein 1 (MATE1) efflux transporter (SLC47A1) in hPTCs exposed to CDDO-Me, suggest that intermittent ..
  44. Aschauer L, Carta G, Vogelsang N, Schlatter E, Jennings P. Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1. Toxicol In Vitro. 2015;30:95-105 pubmed publisher
    ..RPTEC/TERT1 cells expressed OCT2, OCT3, OCTN2, MATE1, MATE2, OAT1, OAT3 and OAT4...
  45. Bexten M, Oswald S, Grube M, Jia J, Graf T, Zimmermann U, et al. Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015;12:171-8 pubmed publisher
    ..SLCO2B1 (OATP2B1), SLCO4A1 (OATP4A1), SLC22A1 (OCT1), SLC22A3 (OCT3), SLC22A4 (OCTN1), SLC22A5 (OCTN2), and SLC47A1 (MATE1). Immuno-reactive P-gp and OATP1A2 were localized to the apical cell layers...
  46. Escaray F, Passeri V, Perea García A, Antonelli C, Damiani F, Ruiz O, et al. The R2R3-MYB TT2b and the bHLH TT8 genes are the major regulators of proanthocyanidin biosynthesis in the leaves of Lotus species. Planta. 2017;246:243-261 pubmed publisher
    ..We found that the levels of leaf PAs significantly correlate with the expression of MATE1, the putative transporter of glycosylated PA monomers, and, among the candidate regulatory genes, with the ..
  47. Celestino Pinto L, de Fátima Aquino Moreira Nunes C, Soares B, Burbano R, de Lemos J, Montenegro R. Mebendazole, an antiparasitic drug, inhibits drug transporters expression in preclinical model of gastric peritoneal carcinomatosis. Toxicol In Vitro. 2017;43:87-91 pubmed publisher
    The present study aimed to investigate whether MBZ down-regulates drug transporter expression (ABCB1, ABCC1, SLC47A1)...
  48. Guo D, Yang H, Li Q, Bae H, Obianom O, Zeng S, et al. Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity. Pharm Res. 2018;35:204 pubmed publisher
    ..on the uptake of the probe substrate metformin was assessed in HEK293 cells overexpressing human OCT2, OCT1, MATE1, MATE2-K, and mouse Oct2, Oct1, and Mate1...
  49. Chapy H, Smirnova M, André P, Schlatter J, Chiadmi F, Couraud P, et al. Carrier-mediated cocaine transport at the blood-brain barrier as a putative mechanism in addiction liability. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..The functionnal characterization suggests that the solute carrier (SLC) transporters Oct (Slc22a1-3), Mate (Slc47a1) and Octn (Slc22a4-5) are not involved in the cocaine transport in vivo and in vitro...
  50. Landini I, Lapucci A, Pratesi A, Massai L, Napoli C, Perrone G, et al. Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017;8:96062-96078 pubmed publisher
    ..g. SLC22A1, SLC47A1, SLCO1B1) and efflux (e.g. ABCB1, ABCC2, ABCC3) transporters...
  51. Uchida Y, Toyohara T, Ohtsuki S, Moriyama Y, Abe T, Terasaki T. Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney. J Pharm Sci. 2016;105:1011-1016 pubmed publisher
    ..In BBM fraction, the protein expression levels of bcrp, urat1, mate1, octl1, mrp4, mdr1a, and abca3 were 40.3, 22.2, 8.90, 4.85, 4.69, 3.22, and 0.976 fmol/μg protein, respectively...
  52. Wang L, Collins C, Kelly E, Chu X, Ray A, Salphati L, et al. Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug Metab Dispos. 2016;44:1752-1758 pubmed
    ..transporters, breast cancer resistance protein (BCRP), bile salt export pump (BSEP), multidrug and toxin extrusion protein 1 (MATE1), multidrug resistance-associated protein (MRP)2, MRP3, MRP4, sodium taurocholate-..
  53. Strobel J, Müller F, Zolk O, Endreß B, Konig J, Fromm M, et al. Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1). Amino Acids. 2013;45:989-1002 pubmed publisher
    ..SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the multidrug and toxin extrusion protein 1 (MATE1, SLC47A1)...
  54. Misaka S, Knop J, Singer K, Hoier E, Keiser M, Müller F, et al. The Nonmetabolized β-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3. Mol Pharm. 2016;13:512-9 pubmed publisher
    ..substrate of the hepatic uptake transporters OATP1B1, OATP1B3, and OCT1 and of the renal transporters OCT2, MATE1, and MATE2-K expressed in HEK cells...
  55. Bruyère A, Hubert C, Le Vee M, Chedik L, Sayyed K, Stieger B, et al. Inhibition of SLC drug transporter activities by environmental bisphenols. Toxicol In Vitro. 2017;40:34-44 pubmed publisher
    ..of the various following SLC transporters were inhibited in a major way (by >60%) by 100?M bisphenols: OCT1 and MATE1 (by BPA and TBBPA), OATP1B1 (by BPA, BPF and TBBPA), OATP1B3 and NTCP (by TBBPA) and OAT3 (by BPA, BPF, BPS and ..
  56. Chung H, Oh J, Yoon S, Yu K, Cho J, Chung J. A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study. PLoS ONE. 2018;13:e0191258 pubmed publisher
    ..Four single nucleotide polymorphisms in MATE1, MATE2-K, and OCT2 were genotyped, and their effects on PK characteristics were additionally evaluated...
  57. Kawasaki T, Matsumoto T, Iwai Y, Kawakami M, Juge N, Omote H, et al. Purification and reconstitution of polyspecific H+/organic cation antiporter human MATE1. Biochim Biophys Acta Biomembr. 2018;1860:2456-2464 pubmed publisher
    Human MATE1 (multidrug and toxin extrusion 1, hMATE1) is a H+/organic cation (OC) exchanger responsible for the final step of toxic organic cation excretion in the kidney and liver...
  58. Li L, Song F, Weng Y, Yang X, Wang K, Lei H, et al. Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride. Br J Pharmacol. 2016;173:2543-54 pubmed publisher
    ..The aim of the present study was to evaluate the role of organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1) in the renal disposition and nephrotoxicity of NC...
  59. Li Q, Ye Z, Zhu P, Guo D, Yang H, Huang J, et al. Indinavir Alters the Pharmacokinetics of Lamivudine Partially via Inhibition of Multidrug and Toxin Extrusion Protein 1 (MATE1). Pharm Res. 2018;35:14 pubmed publisher
    Lamivudine, a characterized substrate for human multidrug and toxin extrusion protein 1 (hMATE1) in vitro, was commonly used with indinavir as a therapy against human immunodeficiency virus (HIV)...
  60. Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, et al. Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation. Drug Metab Dispos. 2016;44:238-49 pubmed publisher
    ..7, 94.7, and 95.4% for OCT2, MATE1, and MATE2K, respectively)...
  61. Klamerus K, Alvey C, Li L, Feng B, Wang R, Kaplan I, et al. Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2. Clin Pharmacol Drug Dev. 2014;3:499-507 pubmed publisher
    ..as a probe transporter substrate, and genotyping for organic cation transporter (OCT) 1, OCT2 and multidrug and toxin extrusion 1 polymorphisms. Twenty-four healthy male subjects completed this open-label, fixed-sequence study...
  62. Liu G, Wen J, Guo D, Wang Z, Hu X, Tang J, et al. The effects of rabeprazole on metformin pharmacokinetics and pharmacodynamics in Chinese healthy volunteers. J Pharmacol Sci. 2016;132:244-248 pubmed publisher
    ..0 ?M, whereas the IC50 on MATE1-mediated metformin transport inhibition was 4.6 ?M...
  63. Chang C, Hu Y, Hogan S, Mercke N, Gomez M, O Bryant C, et al. Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin. Int J Mol Sci. 2017;18: pubmed publisher
    ..1 (GGT1); and (3) efflux by multidrug resistance-associated protein 2 (MRP2) and multidrug and toxin extrusion protein 1 (MATE1)...
  64. Ha Choi J, Wah Yee S, Kim M, Nguyen L, Ho Lee J, Kang J, et al. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009;19:770-80 pubmed publisher
    Human multidrug and toxin extrusion member 1, MATE1 (SLC47A1), plays an important role in the renal and biliary excretion of endogenous and exogenous organic cations including many therapeutic drugs...
  65. Chowdhury S, Yung E, Pintilie M, Muaddi H, Chaib S, Yeung M, et al. MATE2 Expression Is Associated with Cancer Cell Response to Metformin. PLoS ONE. 2016;11:e0165214 pubmed publisher
    ..OCT1 and OCT2 were relatively uniformly expressed, whereas expression of OCT3, MATE1 and MATE2 showed substantial variation across lines...
  66. Vermeer L, Isringhausen C, Ogilvie B, Buckley D. Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters. Drug Metab Dispos. 2016;44:453-9 pubmed publisher
    ..keto-, and N-desalkyl itraconazole) toward 13 drug transporters (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, P-gp, BCRP, MRP2, MRP3, and BSEP) were systematically assessed in transporter-expressing HEK-293 cell ..
  67. Sayyed K, Vee M, Abdel Razzak Z, Jouan E, Stieger B, Denizot C, et al. Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate. Toxicology. 2016;363-364:58-71 pubmed publisher
    ..OATP1B1, OATP1B3, OCT1 and NTCP as well as those of canalicular transporters like P-glycoprotein, MRP2, BCRP and MATE1, in hepatic transporters-overexpressing cells...
  68. Te Brake L, van den Heuvel J, Buaben A, van Crevel R, Bilos A, Russel F, et al. Moxifloxacin Is a Potent In Vitro Inhibitor of OCT- and MATE-Mediated Transport of Metformin and Ethambutol. Antimicrob Agents Chemother. 2016;60:7105-7114 pubmed
    ..HEK293 cells overexpressing OCT1, OCT2, OCT3, MATE1, and MATE2K were used to study TB drug-mediated inhibition of [14C]metformin uptake and to test if TB ..
  69. Nakada T, Kudo T, Kume T, Kusuhara H, Ito K. Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model. Drug Metab Pharmacokinet. 2018;33:103-110 pubmed publisher
    ..secretion of creatinine via renal transporters such as organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K...
  70. Martovetsky G, Bush K, Nigam S. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers. Drug Metab Dispos. 2016;44:1050-60 pubmed publisher
    ..g., Slc22a6/Oat1, Slc47a1/Mate1, Slc22a12/Urat1, Abcg2/Bcrp, Abcc2/Mrp2, Abcc4/Mrp4), nutrient transporters (e.g...
  71. Kajiwara M, Ban T, Matsubara K, Nakanishi Y, Masuda S. Urinary Dopamine as a Potential Index of the Transport Activity of Multidrug and Toxin Extrusion in the Kidney. Int J Mol Sci. 2016;17: pubmed publisher
    ..Here, we show that [³H]dopamine uptake in human (h) MATE1-, hMATE-2K- and mouse (m) MATE-expressing cells exhibited saturable kinetics...
  72. Hibma J, Zur A, Castro R, Wittwer M, Keizer R, Yee S, et al. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016;55:711-21 pubmed publisher
    ..The goal of our study was to determine the effects of selective inhibition of multidrug and toxin extrusion protein 1 (MATE1), using famotidine, on the pharmacokinetics and pharmacodynamics of metformin in healthy ..
  73. Ivanyuk A, Livio F, Biollaz J, Buclin T. Renal Drug Transporters and Drug Interactions. Clin Pharmacokinet. 2017;56:825-892 pubmed publisher
    ..cation transporter (OCT) 2 on the basolateral side, and multidrug and toxic compound extrusion (MATE) proteins MATE1, MATE2/2-K, P-glycoprotein, organic cation and carnitine transporter (OCTN) 1 and OCTN2 on the apical side...
  74. Ekins S, Clark A, Wright S. Making Transporter Models for Drug-Drug Interaction Prediction Mobile. Drug Metab Dispos. 2015;43:1642-5 pubmed publisher
    ..We used recently published transporter data sets (MATE1, MATE2K, OCT2, OCTN2, ASBT, and NTCP) to build preliminary models in a commercial tool and in open software that ..
  75. Burt H, Neuhoff S, Almond L, Gaohua L, Harwood M, Jamei M, et al. Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions. Eur J Pharm Sci. 2016;88:70-82 pubmed publisher
    ..The models were used to simulate inhibition of the MATE1, MATE2-K, OCT1 and OCT2 mediated transport of metformin by cimetidine...
  76. Wagner D, Hu T, Wang J. Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics. Pharmacol Res. 2016;111:237-246 pubmed publisher
    ..which include the organic cation transporters 1-3 (OCT1-3), the multidrug and toxin extrusion proteins 1-2 (MATE1-2) and the plasma membrane monoamine transporter (PMAT)...
  77. Pedersen L, Jensen J, Wogensen L, Munk O, Jessen N, Frøkiær J, et al. Renal PET-imaging with (11)C-metformin in a transgenic mouse model for chronic kidney disease. EJNMMI Res. 2016;6:54 pubmed publisher
    ..Renal protein abundance of OCT2 (by Western blot) as well as OCT1, OCT2, and MATE1 messenger RNA (mRNA) (by RT-PCR) was examined. Protein expression of the basolateral uptake transporter OCT2 was 1...
  78. Yang H, Guo D, Obianom O, Su T, Polli J, Shu Y. Multidrug and toxin extrusion proteins mediate cellular transport of cadmium. Toxicol Appl Pharmacol. 2017;314:55-62 pubmed publisher
    ..HEK-293 cells overexpressing the human MATE1 (HEK-hMATE1), human MATE2-K (HEK-hMATE2-K) and mouse Mate1 (HEK-mMate1) were used to study the cellular transport ..
  79. Lacy S, Hsu B, Miles D, Aftab D, Wang R, Nguyen L. Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites. Drug Metab Dispos. 2015;43:1190-207 pubmed publisher
    ..6 and 1.1 µM, respectively). In an in vitro drug transporter panel, cabozantinib inhibited most potently MATE1 and MATE2-K (IC50 = 5.94 and 3...
  80. Becker M, Visser L, van Schaik R, Hofman A, Uitterlinden A, Stricker B. Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Pharmacogenet Genomics. 2010;20:38-44 pubmed publisher
    ..transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1)...
  81. Winter T, Elmquist W, Fairbanks C. OCT2 and MATE1 provide bidirectional agmatine transport. Mol Pharm. 2011;8:133-42 pubmed publisher
    ..The SLC-family organic cation transporters (OCT) OCT1 and OCT2 and multidrug and toxin extrusion transporter-1 (MATE1) are transport systems that may be of importance for the cellular disposition of agmatine and putrescine...
  82. Sauzay C, White Koning M, Hennebelle I, Deluche T, Delmas C, Imbs D, et al. Inhibition of OCT2, MATE1 and MATE2-K as a possible mechanism of drug interaction between pazopanib and cisplatin. Pharmacol Res. 2016;110:89-95 pubmed publisher
    We hypothesized that pazopanib is an inhibitor of cisplatin renal transporters OCT2, MATE1 and MATE2-K based on previous studies demonstrating an interaction between tyrosine kinase inhibitors and these transporters...
  83. Jacobs C, Pearce B, Hoosain N, Benjeddou M. Lack of genomic diversity in the SLC47A1 gene within the indigenous Xhosa population. Drug Metab Pers Ther. 2016;31:107-14 pubmed publisher
    b>Multidrug and toxin extrusion 1 (MATE1) is an organic cation/H+ exchanger, localized in the apical membrane of proximal renal tubules, which mediates the cellular elimination of organic cations into the renal lumen...
  84. Tzvetkov M, Vormfelde S, Balen D, Meineke I, Schmidt T, Sehrt D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther. 2009;86:299-306 pubmed publisher
    ..We explored metformin pharmacokinetics in relation to genetic variations in OCT1, OCT2, OCT3, OCTN1, and MATE1 in 103 healthy male Caucasians. Renal clearance varied 3...
  85. Shi R, Yang Y, Xu Z, Dai Y, Min Z, Wang T, et al. Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats. Biopharm Drug Dispos. 2017;: pubmed publisher
    ..Thus, berberine is not only a substrate of OCT2 and P-glycoprotein, but also is a substrate of MATE1. Both OCT2 and MATE1 mediate the renal vectorial transport of berberine.
  86. Billington S, Ray A, Salphati L, Xiao G, Chu X, Humphreys W, et al. Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics. Drug Metab Dispos. 2018;46:189-196 pubmed publisher
    Protein expression of major hepatobiliary drug transporters (NTCP, OATPs, OCT1, BSEP, BCRP, MATE1, MRPs, and P-gp) in cancerous (C, n = 8) and adjacent noncancerous (NC, n = 33) liver tissues obtained from patients with ..
  87. Ohta K, Inoue K, Yasujima T, Ishimaru M, Yuasa H. Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds. J Pharm Pharm Sci. 2009;12:388-96 pubmed
    Human multidrug and toxin extrusion protein 1 (hMATE1) and hMATE2-K are organic cation/H+ antiporters that have recently been identified and suggested to be involved in the renal brush border secretion of various organic cations...
  88. Iwata K, Aizawa K, Kamitsu S, Jingami S, Fukunaga E, Yoshida M, et al. Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events. Clin Exp Nephrol. 2012;16:843-51 pubmed publisher
    ..organic cation transporter 2 (OCT2) and secreted into lumen via other transporters including SLC47A1 multidrug and toxin extrusion 1 (MATE1)...
  89. Zhang X, He X, Baker J, Tama F, Chang G, Wright S. Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. J Biol Chem. 2012;287:27971-82 pubmed publisher
    ..Here we affirm this prediction, showing that the C termini of epitope-tagged, full-length human, rabbit, and mouse MATE1 were accessible to antibodies from the extracellular face of the membrane...
  90. Lee J, Lee J, Kim Y, Lee H, Jun H, Lee S. Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter. J Agric Food Chem. 2014;62:9690-8 pubmed publisher
    ..We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin...
  91. Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, et al. LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line. Mol Pharm. 2017;14:605-613 pubmed publisher
    ..MRP1, MRP5, GLUT1, 4F2hc, TAUT, CAT1, LAT1, and MATE1 proteins were detected in both cell lines within 4-fold differences...
  92. Nakano K, Ando H, Kurokawa S, Hosohata K, Ushijima K, Takada M, et al. Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury. Cancer Chemother Pharmacol. 2015;75:1191-7 pubmed publisher
    ..PCR analysis of both the training set and validation set confirmed that mRNA levels of multidrug and toxin extrusion protein 1 (MATE1 or SLC47A1, encoded by 1 of the 11 genes) were significantly lower in patients with FILI...