SLC40A1

Summary

Gene Symbol: SLC40A1
Description: solute carrier family 40 member 1
Alias: FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3, solute carrier family 40 member 1, iron regulated gene 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, solute carrier family 40 (iron-regulated transporter), member 1
Species: human
Products:     SLC40A1

Top Publications

  1. Beutler E, Barton J, Felitti V, Gelbart T, West C, Lee P, et al. Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans. Blood Cells Mol Dis. 2003;31:305-9 pubmed
    ..This variant is associated with increased ferritin levels in African-Americans and may play a role in their propensity to develop iron overload. ..
  2. McKie A, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299-309 pubmed
    ..We describe here the isolation and characterization of a novel cDNA (Ireg1) encoding a duodenal protein that is localized to the basolateral membrane of polarized epithelial cells...
  3. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt S, Moynihan J, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776-81 pubmed
    ..We propose that Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload. ..
  4. Sham R, Phatak P, West C, Lee P, Andrews C, Beutler E. Autosomal dominant hereditary hemochromatosis associated with a novel ferroportin mutation and unique clinical features. Blood Cells Mol Dis. 2005;34:157-61 pubmed
    ..The disease in this family is notable for young age at onset, elevated transferrin saturation values, and hepatocyte iron deposition. The distinct molecular and clinical features reflect the heterogeneous nature of this disease. ..
  5. Wallace D, Dixon J, Ramm G, Anderson G, Powell L, Subramaniam V. A novel mutation in ferroportin implicated in iron overload. J Hepatol. 2007;46:921-6 pubmed
    ..The S338R mutation results in a mutated ferroportin associated with iron overload and is predicted insensitive to regulation by the iron regulatory hormone hepcidin. ..
  6. Wallace D, Harris J, Subramaniam V. Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype. Am J Physiol Cell Physiol. 2010;298:C75-84 pubmed publisher
    ..Conversely, loss-of-function variants were located at the membrane/cytoplasm interface. ..
  7. Griffiths W, Mayr R, McFarlane I, Hermann M, Halsall D, Zoller H, et al. Clinical presentation and molecular pathophysiology of autosomal dominant hemochromatosis caused by a novel ferroportin mutation. Hepatology. 2010;51:788-95 pubmed publisher
    Mutations in the SLC40A1 gene, which encodes ferroportin, are associated with autosomal dominant hemochromatosis...
  8. Arden K, Wallace D, Dixon J, Summerville L, Searle J, Anderson G, et al. A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient. Gut. 2003;52:1215-7 pubmed
    ..This is the first identified mutation associated with haemochromatosis in the Solomon Islands population. ..
  9. Drakesmith H, Schimanski L, Ormerod E, Merryweather Clarke A, Viprakasit V, Edwards J, et al. Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. Blood. 2005;106:1092-7 pubmed
    ..FPN-linked hemochromatosis may have a variable pathogenesis depending on the causative FPN mutant. ..

More Information

Publications81

  1. Hetet G, Devaux I, Soufir N, Grandchamp B, Beaumont C. Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations. Blood. 2003;102:1904-10 pubmed
    ..This raises the intriguing possibility that lens ferritin accumulation might be a factor contributing to age-related cataract in the general population. Additional causes of isolated hyperferritinemia remain to be identified. ..
  2. Abboud S, Haile D. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906-12 pubmed
    ..This gene, termed metal transporter protein (mtp1), is expressed in tissues involved in body iron homeostasis including the developing and mature reticuloendothelial ..
  3. Duce J, Tsatsanis A, Cater M, James S, Robb E, Wikhe K, et al. Iron-export ferroxidase activity of ?-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010;142:857-67 pubmed publisher
    ..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD. ..
  4. Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis. 2004;32:131-8 pubmed
    ..The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally ..
  5. Politou M, Kalotychou V, Pissia M, Rombos Y, Sakellaropoulos N, Papanikolaou G. The impact of the mutations of the HFE gene and of the SLC11A3 gene on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients. Haematologica. 2004;89:490-2 pubmed
    ..Neither HFE (C282Y and H63D) nor ferroportin(Val162del) mutations were determinants of total body iron status, as assessed by ferritin levels, in either group of patients. ..
  6. Letocart E, Le Gac G, Majore S, Ka C, Radio F, Gourlaouen I, et al. A novel missense mutation in SLC40A1 results in resistance to hepcidin and confirms the existence of two ferroportin-associated iron overload diseases. Br J Haematol. 2009;147:379-85 pubmed publisher
    ..These findings confirm that certain ferroportin mutations compromise the activity of hepcidin in iron homeostasis, mimicking hepcidin deficiency as described in all types of hemochromatosis. ..
  7. Roetto A, Merryweather Clarke A, Daraio F, Livesey K, Pointon J, Barbabietola G, et al. A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4. Blood. 2002;100:733-4 pubmed
  8. Pelucchi S, Mariani R, Salvioni A, Bonfadini S, Riva A, Bertola F, et al. Novel mutations of the ferroportin gene (SLC40A1): analysis of 56 consecutive patients with unexplained iron overload. Clin Genet. 2008;73:171-8 pubmed publisher
    The aim of this study was to search for SLC40A1 mutations in iron overloaded patients, which tested negative for HFE mutations and other iron-related genes...
  9. Rice A, Mendez M, Hokanson C, Rees D, Bjorkman P. Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter. J Mol Biol. 2009;386:717-32 pubmed publisher
    ..The characterizations reported here form a basis upon which models for ferroportin's role in regulating iron homeostasis in health and disease can be interpreted. ..
  10. Njajou O, Vaessen N, Joosse M, Berghuis B, van Dongen J, Breuning M, et al. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis. Nat Genet. 2001;28:213-4 pubmed
    ..1-4). We report that a mutation in the gene encoding Solute Carrier family 11, member A3 (SLC11A3), also known as ferroportin, is associated with autosomal dominant hemochromatosis.
  11. Speletas M, Kioumi A, Loules G, Hytiroglou P, Tsitouridis J, Christakis J, et al. Analysis of SLC40A1 gene at the mRNA level reveals rapidly the causative mutations in patients with hereditary hemochromatosis type IV. Blood Cells Mol Dis. 2008;40:353-9 pubmed
    Mutations in the SLC40A1 gene result in a dominant genetic disorder [ferroportin disease; hereditary hemochromatosis type (HH) IV], characterized by iron overload with two different clinical manifestations, normal transferrin saturation ..
  12. Cremonesi L, Cemonesi L, Forni G, Soriani N, Lamagna M, Fermo I, et al. Genetic and clinical heterogeneity of ferroportin disease. Br J Haematol. 2005;131:663-70 pubmed
    Ferroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin...
  13. Zaahl M, Merryweather Clarke A, Kotze M, van der Merwe S, Warnich L, Robson K. Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload. Hum Genet. 2004;115:409-17 pubmed
    ..The possible involvement of genes affecting iron homeostasis, including HFE, SLC40A1, HAMP and CYBRD1, was investigated in individuals who were referred for confirmation or exclusion of a diagnosis ..
  14. Yang F, Liu X, Quinones M, Melby P, Ghio A, Haile D. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 2002;277:39786-91 pubmed
    ..This change in iron metabolism contributes to the development of the anemia of inflammation. MTP1, the duodenal enterocyte basolateral iron exporter, is also expressed in the cells of the reticuloendothelial ..
  15. Barton J, Acton R, Lee P, West C. SLC40A1 Q248H allele frequencies and Q248H-associated risk of non-HFE iron overload in persons of sub-Saharan African descent. Blood Cells Mol Dis. 2007;39:206-11 pubmed
    The ferroportin polymorphism SLC40A1 Q248H (exon 6, cDNA 744G-->T; Gln248His) occurs in persons of sub-Saharan African descent with and without iron overload, and is associated with elevated serum ferritin concentrations (SF)...
  16. Gordeuk V, Caleffi A, Corradini E, Ferrara F, Jones R, Castro O, et al. Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene. Blood Cells Mol Dis. 2003;31:299-304 pubmed
    The product of the SLC40A1 gene, ferroportin 1, is a main iron export protein...
  17. Mayr R, Griffiths W, Hermann M, McFarlane I, Halsall D, Finkenstedt A, et al. Identification of mutations in SLC40A1 that affect ferroportin function and phenotype of human ferroportin iron overload. Gastroenterology. 2011;140:2056-63, 2063.e1 pubmed publisher
    Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation...
  18. Nemeth E, Tuttle M, Powelson J, Vaughn M, Donovan A, Ward D, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-3 pubmed
    ..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface. ..
  19. Wallace D, Pedersen P, Dixon J, Stephenson P, Searle J, Powell L, et al. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. Blood. 2002;100:692-4 pubmed
    ..We propose that this mutation disrupts the function of the ferroportin1 protein, leading to impaired iron homeostasis and iron overload. ..
  20. Lim F, Dooley J, Roques A, Grellier L, Dhillon A, Walker A. Hepatic iron concentration, fibrosis and response to venesection associated with the A77D and V162del "loss of function" mutations in ferroportin disease. Blood Cells Mol Dis. 2008;40:328-33 pubmed
    ..It is important for clinicians to consider ferroportin disease in cases where there are features of iron overload unrelated to HFE, autosomal dominant inheritance and/or iron deposition in mononuclear phagocytes. ..
  21. Lee P, Gelbart T, West C, Barton J. SLC40A1 c.1402G-->a results in aberrant splicing, ferroportin truncation after glycine 330, and an autosomal dominant hemochromatosis phenotype. Acta Haematol. 2007;118:237-41 pubmed
    ..We sequenced genomic DNA to detect mutations of HFE, SLC40A1, TFR2, HAMP, and HFE2. RNA isolated from blood mononuclear cells was used to make cDNA...
  22. Sham R, Phatak P, Nemeth E, Ganz T. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood. 2009;114:493-4 pubmed publisher
  23. Harada N, Kanayama M, Maruyama A, Yoshida A, Tazumi K, Hosoya T, et al. Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages. Arch Biochem Biophys. 2011;508:101-9 pubmed publisher
    ..Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization...
  24. Schimanski L, Drakesmith H, Merryweather Clarke A, Viprakasit V, Edwards J, Sweetland E, et al. In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. Blood. 2005;105:4096-102 pubmed
    Type IV hemochromatosis is associated with dominant mutations in the SLC40A1 gene encoding ferroportin (FPN)...
  25. Rivard S, Lanzara C, Grimard D, Carella M, Simard H, Ficarella R, et al. Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family. Haematologica. 2003;88:824-6 pubmed
  26. De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, et al. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 2006;91:1092-5 pubmed
    ..We suggest that FpnG80S represents a class of Fpn mutants whose behavior in vitro does not explain the patients' phenotype. ..
  27. de Diego C, Opazo S, Murga M, Martínez Castro P. H63D homozygotes with hyperferritinaemia: Is this genotype, the primary cause of iron overload?. Eur J Haematol. 2007;78:66-71 pubmed
    ..The simultaneous detection of 18 known HFE, TFR2 and FPN1 mutations and sequencing of the HAMP gene were performed to rule out the possible existence of genetic modifier ..
  28. Montosi G, Donovan A, Totaro A, Garuti C, Pignatti E, Cassanelli S, et al. Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. J Clin Invest. 2001;108:619-23 pubmed
    ..The gene encoding ferroportin (SLC11A3), a transmembrane iron export protein, lies within a candidate interval defined by highly significant lod scores...
  29. Duca L, Delbini P, Nava I, Vaja V, Fiorelli G, Cappellini M. Mutation analysis of hepcidin and ferroportin genes in Italian prospective blood donors with iron overload. Am J Hematol. 2009;84:592-3 pubmed publisher
    ..Recently, hepcidin has been shown to regulate iron homeostasis by interaction with ferroportin, an iron cellular exporter highly expressed in absorptive enterocytes, macrophages, hepatocytes, and placental cells [4]. ..
  30. Cazzola M, Cremonesi L, Papaioannou M, Soriani N, Kioumi A, Charalambidou A, et al. Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3). Br J Haematol. 2002;119:539-46 pubmed
    ..Sequence analysis of the ferroportin gene (SLC11A3) in four individuals with hyperferritinaemia singled out a three base pair deletion in a region that contains ..
  31. Sussman N, Lee P, Dries A, Schwartz M, Barton J. Multi-organ iron overload in an African-American man with ALAS2 R452S and SLC40A1 R561G. Acta Haematol. 2008;120:168-73 pubmed publisher
    ..We amplified and directly sequenced his genomic DNA to detect mutations of SLC40A1, HFE, TFR2, HAMP, HJV and ALAS2...
  32. Jouanolle A, Douabin Gicquel V, Halimi C, Loreal O, Fergelot P, Delacour T, et al. Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload. J Hepatol. 2003;39:286-9 pubmed
    ..Given this dominant transmission, the mixed Causasian-Asian origin of our Asian proband leaves open the issue of the ethnic origin of the new mutation. ..
  33. Mehta K, Greenwell P, Renshaw D, Busbridge M, Garcia M, Farnaud S, et al. Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells. Blood Cells Mol Dis. 2015;55:110-8 pubmed publisher
    ..While TFRC mRNA expression showed expected elevation (2h, p < 0.03; 4h; p < 0.05), slc40a1 mRNA expression was also elevated (2 h, p < 0.05; 4 h, p < 0.03), unlike the HepG2 cells...
  34. Le Gac G, Ka C, Joubrel R, Gourlaouen I, Lehn P, Mornon J, et al. Structure-function analysis of the human ferroportin iron exporter (SLC40A1): effect of hemochromatosis type 4 disease mutations and identification of critical residues. Hum Mutat. 2013;34:1371-80 pubmed publisher
    Ferroportin (SLC40A1) is the only known iron exporter in mammals and is considered a key coordinator of the iron balance between intracellular and systemic iron homeostasis...
  35. Abraham B, Justenhoven C, Pesch B, Harth V, Weirich G, Baisch C, et al. Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:1102-7 pubmed
    ..transferrin receptor system mutations in breast cancer, we analyzed 19 sequence variations at HFE, TFR1, TFR2, and FPN1 and compared genotype frequencies between cases and controls in a German population...
  36. Li Y, Yu P, Chang S, Wu Q, Yu P, Xie C, et al. Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. J Cell Biochem. 2017;118:1596-1605 pubmed publisher
    ..transport proteins, including transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin1 (FPN1), were also altered...
  37. Babu K, Muckenthaler M. miR-20a regulates expression of the iron exporter ferroportin in lung cancer. J Mol Med (Berl). 2016;94:347-59 pubmed publisher
    ..Low FPN expression stimulates proliferation and colony formation of non-small cell lung cancer (NSCLC) cells, possibly by increasing iron availability for cancer cell proliferation. ..
  38. Hallenbeck P, Grogger M, Mraz M, Veverka D. Draft Genome Sequence of a Thermophilic Cyanobacterium from the Family Oscillatoriales (Strain MTP1) from the Chalk River, Colorado. Genome Announc. 2016;4: pubmed publisher
    The draft genome (57.7% GC, 7,647,882 bp) of the novel thermophilic cyanobacterium MTP1 was determined by metagenomics of an enrichment culture...
  39. Ha J, Doguer C, Collins J. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics. 2016;8:963-972 pubmed
    ..Expression of Dmt1 (the iron importer), Dcytb (an apical membrane ferrireductase) and Fpn1 (the iron exporter) was decreased in Atp7a knockdown (KD) cells...
  40. Sheokand N, Malhotra H, Chauhan A, Kumar M, Chaudhary S, Patidar A, et al. Reverse overshot water-wheel retroendocytosis of apotransferrin extrudes cellular iron. J Cell Sci. 2016;129:843-53 pubmed publisher
    ..understood, its export is thought to be limited to transmembrane extrusion through ferroportin (also known as Slc40a1), the only known mammalian Fe exporter...
  41. Chen Y, Zhang Z, Yang K, Du J, Xu Y, Liu S. Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress. Oncogene. 2015;34:3839-47 pubmed publisher
    ..Targeting molecules within the MZF-1-FPN signaling thus appears to be a promising approach to restrain prostate cancer. ..
  42. Nekhai S, Xu M, Foster A, Kasvosve I, Diaz S, Machado R, et al. Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin. Haematologica. 2013;98:455-63 pubmed publisher
    ..ClinicalTrials.gov Identifier:NCT00011648). ..
  43. Bergamaschi G, Di Sabatino A, Pasini A, Ubezio C, Costanzo F, Grataroli D, et al. Intestinal expression of genes implicated in iron absorption and their regulation by hepcidin. Clin Nutr. 2017;36:1427-1433 pubmed publisher
    ..Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release ..
  44. Kasztura M, Dzięgała M, Kobak K, Bania J, Mazur G, Banasiak W, et al. Both iron excess and iron depletion impair viability of rat H9C2 cardiomyocytes and L6G8C5 myocytes. Kardiol Pol. 2017;75:267-275 pubmed publisher
    ..and light chains (FTH and FTL; iron storage proteins), myoglobin (MB, oxygen storage protein) ferroportin type 1 (FPN1; iron exporter), transferrin receptor type 1 (TfR1; iron importer), hepcidin (HAMP; iron metabolism regulator) ..
  45. Yang X, Park S, Chang H, Shapiro J, Vassilopoulos A, Sawicki K, et al. Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. J Clin Invest. 2017;127:1505-1516 pubmed publisher
    ..The reduction in nuclear NRF2 leads to reduced ferroportin 1 (FPN1) expression, which in turn results in decreased cellular iron export...
  46. Li X, Liao X, Zhang L, Lu L, Luo X. Effect of iron source on iron absorption and gene expression of iron transporters in the ligated duodenal loops of broilers. J Anim Sci. 2017;95:1587-1597 pubmed publisher
    ..of iron source on Fe absorption and the gene expression of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in the ligated duodenal loops of broilers...
  47. Kohgo Y. A novel ferroportin disease in a Japanese patient. Intern Med. 2005;44:393-4 pubmed
  48. Wang J, Xu L, Yao X, Fang J. [Expression Changes of Hepcidin and Ferroportin 1 in Murine Model of Iron Overload]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:936-940 pubmed publisher
    ..05). The expressions of hepcidin and ferroportin 1 are increase in a murine model of iron overload, which may be contributed to the suppression effect on erythropoiesis in bone marrow. ..
  49. Rolfs A, Bonkovsky H, Kohlroser J, McNeal K, Sharma A, Berger U, et al. Intestinal expression of genes involved in iron absorption in humans. Am J Physiol Gastrointest Liver Physiol. 2002;282:G598-607 pubmed
    ..quantitative PCR, we measured mRNA expression of divalent cation transporter 1 (DCT1), iron-regulated gene 1 (IREG1), and hephaestin in duodenal biopsy samples of individuals with normal iron levels, iron-deficiency anemia, or ..
  50. Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin. Cell Metab. 2015;22:777-87 pubmed publisher
    ..Fundamental questions about the structure and biology of ferroportin remain to be answered. ..
  51. Habib A, Polavarapu R, Karmali V, Guo L, Van Dam R, Cheng Q, et al. Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques. Atherosclerosis. 2015;241:692-700 pubmed publisher
    ..Pharmacologic manipulation of iron metabolism may represent a promising approach to limiting TLR4-mediated inflammatory responses. ..
  52. Kasvosve I, Gomo Z, Nathoo K, Matibe P, Mudenge B, Loyevsky M, et al. Effect of ferroportin Q248H polymorphism on iron status in African children. Am J Clin Nutr. 2005;82:1102-6 pubmed
    ..07; P = 0.068). Any effect of Q248H in protecting against iron deficiency may be observable in children exposed to repeated inflammatory conditions. Further studies of iron status and ferroportin Q248H in African children are needed. ..
  53. Sabelli M, Montosi G, Garuti C, Caleffi A, Oliveto S, Biffo S, et al. Human macrophage ferroportin biology and the basis for the ferroportin disease. Hepatology. 2017;65:1512-1525 pubmed publisher
    Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell-specific function and regulation are still elusive...
  54. Vargas J, Munoz A, Samper B, Bornstein B. [Usefulness of a diagnostic algorithm hyperferritinemia: A case report of a Spanish family with hereditary hemochromatosis and mutation in SLC40A1 gene]. Med Clin (Barc). 2015;145:42-3 pubmed publisher
  55. Zhang D, Wu J, Shah B, Greutélaers K, Ghosh M, Ollivierre H, et al. Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk. Science. 2018;359:1520-1523 pubmed publisher
    ..i>FPN Q248H appears to have been positively selected in African populations in response to the impact of malaria disease. Thus, FPN protects RBCs against oxidative stress and malaria infection. ..
  56. Yang J, Zhang J, Ding C, Dong D, Shang P. Regulation of Osteoblast Differentiation and Iron Content in MC3T3-E1 Cells by Static Magnetic Field with Different Intensities. Biol Trace Elem Res. 2018;184:214-225 pubmed publisher
    ..At the same time, HiMF of 16 T and MMF of 0.2 T increased the expression of ferroportin 1 (FPN1)...
  57. Thomas C, Oates P. IEC-6 cells are an appropriate model of intestinal iron absorption in rats. J Nutr. 2002;132:680-7 pubmed
    ..in iron absorption such as the uptake transporter-divalent metal transporter (DMT1), the basolateral transporter, IREG1, and the ferroxidase-hephaestin provide new opportunities to study this process...
  58. Le Lan C, Mosser A, Ropert M, Detivaud L, Loustaud Ratti V, Vital Durand D, et al. Sex and acquired cofactors determine phenotypes of ferroportin disease. Gastroenterology. 2011;140:1199-1207.e1-2 pubmed publisher
    ..It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin...
  59. Sornjai W, Jaratsittisin J, Khungwanmaythawee K, Svasti S, Fucharoen S, Lithanatudom P, et al. Dysregulation of ferroportin gene expression in β(0)-thalassemia/Hb E disease. Ann Hematol. 2016;95:387-96 pubmed publisher
    ..These results are consisted with dysregulation of iron efflux from the maturing erythroblast in β(0)-thalassemia/Hb E patients, and this dysregulation possibly contributes to ineffective erythropoiesis seen in these patients. ..
  60. Du Thanh A, Martinez P, Cunat S, Bessis D, Guillot B, Dereure O. Absence of functional mutations in the ferroportin-encoding SLC40A1 gene in porphyria cutanea tarda: a series of 37 cases from southern France. Acta Derm Venereol. 2011;91:467 pubmed publisher
  61. Wu J, Bao L, Zhang Z, Yi X. Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells. Oncotarget. 2017;8:93502-93515 pubmed publisher
    ..b>Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites...
  62. Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, et al. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cell Signal. 2014;26:2539-50 pubmed publisher
    ..Thus, targeting the hepcidin-ferroportin signaling would represent a promising therapeutics to restrain breast cancer growth. ..
  63. Kasvosve I. Effect of ferroportin polymorphism on iron homeostasis and infection. Clin Chim Acta. 2013;416:20-5 pubmed publisher
    ..Conversely, iron retention due to loss of iron export activity by mutated FPN results in intracellular iron accumulation and a permissive environment for intracellular pathogens. ..
  64. Xu M, Kashanchi F, Foster A, Rotimi J, Turner W, Gordeuk V, et al. Hepcidin induces HIV-1 transcription inhibited by ferroportin. Retrovirology. 2010;7:104 pubmed publisher
  65. Usuelli F, Tamini J, Maccario C, Grassi M, Tan E. Bone-block arthrodesis procedure in failures of first metatarsophalangeal joint replacement. Foot Ankle Surg. 2017;23:163-167 pubmed publisher
    The treatment for the failure of a first metatarsophalangeal joint (MTP1) prosthesis can be complex. There is no consensus regarding the ideal treatment. One of the main issues is the available bone stock after prosthesis removal...
  66. XU M, Wang J, Xie J. Regulation of iron metabolism by hypoxia-inducible factors. Sheng Li Xue Bao. 2017;69:598-610 pubmed
    ..by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR)...
  67. Ross S, Tran L, Winters A, Lee K, Plewa C, Foltz I, et al. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell Metab. 2012;15:905-17 pubmed publisher
    ..In vivo, inhibition of JAK2 had no effect on Hepc-induced hypoferremia. However, internalization was delayed by mutation of two Fpn lysine residues that may be targets of ubiquitination. ..
  68. Xu Y, Zhang W, Zhang P, Xiao L, Wang A, Sirois P, et al. Downregulation of ferroportin 1 expression in hFOB1.19 osteoblasts by hepcidin. Inflammation. 2012;35:1058-61 pubmed publisher
    ..Our data indicate that osteoblasts are target cells for hepcidin, suggest that hepcidin may have many more targets than previously recognized, and support the role of hepcidin in the development of osteoporosis. ..
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    ..and mRNA levels of transferrin receptor (TfR1), TfR2, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in Huh7...
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    ..Studies with larger numbers of participants are needed to further clarify the relationship of ferroportin Q248H with the toxicity of alcohol consumption. ..
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    ..Both forms demonstrate autosomal dominant transmission and are associated with ferroportin gene (SLC40A1) mutations. SLC40A1 encodes a cellular iron exporter expressed in macrophages, enterocytes, and hepatocytes...