Gene Symbol: SLC39A8
Description: solute carrier family 39 member 8
Alias: BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8, zinc transporter ZIP8, BCG induced integral membrane protein BIGM103, BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, ZIP-8, Zrt- and Irt-like protein 8, solute carrier family 39 (metal ion transporter), member 8
Species: human
Products:     SLC39A8

Top Publications

  1. van Raaij S, Srai S, Swinkels D, Van Swelm R. Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells. Biometals. 2019;32:211-226 pubmed publisher
    ..Ferrous iron importers ZIP8 and ZIP14 were localized in the ciPTEC plasma membrane...
  2. BESECKER B, Exline M, Hollyfield J, Phillips G, DiSilvestro R, Wewers M, et al. A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. Am J Clin Nutr. 2011;93:1356-64 pubmed publisher
    ..5 ± 18.1 μg/dL). Cytokine concentrations increased with decreasing plasma zinc concentrations (P = 0.05). SLC39A8 gene expression was highest in patients with the lowest plasma zinc concentrations and the highest severity of ..
  3. Villaseñor Granados T, Díaz Cervantes E, Soto Arredondo K, Martínez Alfaro M, Robles J, García Revilla M. Binding of Pb-Melatonin and Pb-(Melatonin-metabolites) complexes with DMT1 and ZIP8: implications for lead detoxification. Daru. 2019;: pubmed publisher characterize the binding modes of the divalent metal transporter 1 (DMT1) and the zinc transporter 8 (ZIP8) protein channels with: melatonin, some melatonin metabolites, and a few lead complexes of melatonin and its ..
  4. McCoy T, Pellegrini A, Perlis R. Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8. Transl Psychiatry. 2019;9:45 pubmed publisher
    ..corresponds to a missense variant associated with change in efficiency of a metal ion transporter, ZIP8, coded by SLC39A8. This variant has been linked to a range of phenotypes and is believed to be under recent selection pressure, but ..
  5. Saito K, Fujiwara T, Hatta S, Morita M, Ono K, Suzuki C, et al. Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation. Mol Cell Biol. 2019;39: pubmed publisher
    ..into mature erythroblasts and became ring sideroblasts with upregulation of metal transporters (MFRN1, ZIP8, and DMT1), suggesting a key role for ferrous iron in erythroid differentiation...
  6. Thevenod F, Fels J, Lee W, Zarbock R. Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts. Biometals. 2019;: pubmed publisher
    ..transient receptor potential (TRP) channels (TRPA1, TRPV5/6, TRPML1), solute carriers (SLCs) (DMT1/SLC11A2, ZIP8/SLC39A8, ZIP14/SLC39A14), amino acid/cystine transporters (SLC7A9/SLC3A1, SLC7A9/SLC7A13), and Cd2+-protein ..
  7. Geng X, Liu L, Tsai K, Liu Z. Role of ZIP8 in regulation of cisplatin sensitivity through Bcl-2. Toxicol Appl Pharmacol. 2019;362:52-58 pubmed publisher
    b>ZIP8 is a membrane transporter that facilitates the uptake of divalent metals (e.g., Zn, Mn, Fe, Cd) and the mineral selenite in anionic form...
  8. Olgar Y, Turan B. A SGLT2 inhibitor dapagliflozin comparison with insulin exerts important effects on Zn2+-transporters in cardiomyocytes from insulin-resistant metabolic syndrome rats through inhibition of oxidative stress. Can J Physiol Pharmacol. 2018;: pubmed publisher
    ..of Zn2+-transporters, responsible from Zn2+-influx into cytosol, ZIP7 and ZIP14 were decreased with no change in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible from cytosolic Zn2+-efflux, ZnT7 was decreased...
  9. Sun Q, Zhong W, Zhang W, Li Q, Sun X, Tan X, et al. Zinc deficiency mediates alcohol-induced apoptotic cell death in the liver of rats through activating ER and mitochondrial cell death pathways. Am J Physiol Gastrointest Liver Physiol. 2015;308:G757-66 pubmed publisher
    ..Among the detected zinc transporters, ER Zrt/Irt-like protein (ZIP)13 and mitochondrial ZIP8, which transport zinc from ER and mitochondria to cytosol, were significantly increased...

More Information


  1. Williams M, Almén M, Fredriksson R, Schioth H. What model organisms and interactomics can reveal about the genetics of human obesity. Cell Mol Life Sci. 2012;69:3819-34 pubmed publisher
    ..gpcr5b, lrp1b, negr1, nrxn3, sh2b1, fancl, gnpda2, hmgcr, map2k5, nudt3, prkd1, qpctl, tnni3k, mtch2, dnajc27, slc39a8, mtif3, rpl27a, sec16b, etv5, hmga1, tfap2b, tub, znf608, faim2, kctd15, lingo2, poc5, ptbp2, tmem18, tmem160)...
  2. Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, et al. A missense variant in SLC39A8 is associated with severe idiopathic scoliosis. Nat Commun. 2018;9:4171 pubmed publisher
    ..We find a missense SNP in SLC39A8 (p.Ala391Thr, rs13107325) associated with severe AIS (P = 1.60 × 10-7, OR = 2...
  3. Knutson M. Non-transferrin-bound iron transporters. Free Radic Biol Med. 2019;133:101-111 pubmed publisher mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6...
  4. Gao Y, Xu Y, Wu D, Yu F, Yang L, Yao Y, et al. Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithelial cells. Acta Biochim Biophys Sin (Shanghai). 2017;49:444-449 pubmed publisher
    ..The zinc transporters Zip8, Zip14, and divalent metal transporter 1 (Dmt1) are now emerging as several important metal transporters involved ..
  5. Yin X, Jiang L, Ma Y, Xu J, Gu H, Wu X, et al. Decreased Zn(2+) Influx Underlies the Protective Role of Hypoxia in Rat Nucleus Pulposus Cells. Biol Trace Elem Res. 2015;168:196-205 pubmed publisher
    ..b>ZIP8, a main Zn(2+) transporter in chondrocytes, was assayed by immunochemistry and in Western blotting...
  6. Tanimura N, Liao R, Wilson G, Dent M, Cao M, Burstyn J, et al. GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism. Dev Cell. 2018;46:581-594.e4 pubmed publisher
    ..Though GATA-1 induced expression of Slc30a1 and the zinc importer Slc39a8, Slc39a8 dominantly increased intracellular zinc, which conferred erythroblast survival...
  7. Soto Arredondo K, Robles J, Díaz Cervantes E, Ruiz Ramírez C, García Revilla M, Wrobel K, et al. Effects of lead and lead-melatonin exposure on protein and gene expression of metal transporters, proteins and the copper/zinc ratio in rats. Biometals. 2018;31:859-871 pubmed publisher
    ..and co-administration of lead and melatonin affect the gene and protein expression of metal transporter proteins (ZIP8, ZIP14, CTR1 and DMT1) in these organs. Rats were exposed intraperitoneally to lead or lead-melatonin...
  8. Zang Z, Xu Y, Lau A. Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8). Toxicol Res (Camb). 2016;5:987-1002 pubmed publisher
    ..The Zn transporter ZIP8 (also known as SLC39A8) is an important Zn2+ importer; aberrant Zn2+ influx mediated by ZIP8 can lead to the ..
  9. Xu Y, Gao Y, Wu D, Yu F, Zang Z, Yang L, et al. Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells. Proteomics Clin Appl. 2017;11: pubmed publisher
    ..Here, we explored further and found that the zinc (Zn) importer Zip8 was stably abolished in these cells along with a marked decrease of Cd and Zn accumulation...
  10. Ji C, Kosman D. Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons. J Neurochem. 2015;133:668-83 pubmed publisher
    ..In this study, we characterized the expression and localization of ferrous iron transporters Zip8, Zip14 and divalent metal transporter 1 (DMT1), and ferrireductases Steap2 and stromal cell-derived receptor 2 in ..
  11. Geng X, Liu L, BANES BERCELI A, Yang Z, Kang P, Shen J, et al. Role of ZIP8 in regulating cell morphology and NF-κB/Snail2 signaling. Metallomics. 2018;10:953-964 pubmed publisher
    b>ZIP8 is a recently identified membrane transporter which facilitates uptake of many substrates including both essential and toxic divalent metals (e.g. zinc, manganese, iron, cadmium) and inorganic selenium...
  12. Kim H, Rhee J, Park S, Yang J, Chun J. Upregulation of Atrogin-1/FBXO32 is not necessary for cartilage destruction in mouse models of osteoarthritis. Osteoarthritis Cartilage. 2017;25:397-400 pubmed publisher
    ..catabolic regulators of osteoarthritis (OA), including hypoxia-inducible factor (HIF)-2α and members of the zinc-ZIP8-MTF1 axis, upregulate the E3 ubiquitin ligase, Atrogin-1 (encoded by Fbxo32), in chondrocytes...
  13. Cheng G, Chang F, You P, Lin J, Huang X, Wu H, et al. ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx. Int Immunopharmacol. 2018;62:203-211 pubmed publisher
    ..transporters between non-adhering and adhering monocytes, we found that the Zn2+ importer ZIP8 was specifically upregulated in monocytes adhering to the aortas ex-vivo...
  14. van Raaij S, van Swelm R, Bouman K, Cliteur M, van den Heuvel M, Pertijs J, et al. Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease. Sci Rep. 2018;8:9353 pubmed publisher
    ..In healthy kidney, PT contained proteins required for iron recycling including putative iron importers ZIP8, ZIP14, DMT1, iron storage proteins L- and H-ferritin and iron exporter ferroportin, while DT only contained ZIP8, ..
  15. Komjarova I, Bury N. Evidence of common cadmium and copper uptake routes in zebrafish Danio rerio. Environ Sci Technol. 2014;48:12946-51 pubmed publisher
    ..of genes involved in the transport of Cu (CTR1 and ATP7A), Na (NHE-2), Ca (ECaC), divalent metals (DMT1), and Zn (ZIP8) were also compared between treatments at 24 and 48 h...
  16. Chen J, Galvez Peralta M, Zhang X, Deng J, Liu Z, Nebert D. In utero gene expression in the Slc39a8(neo/neo) knockdown mouse. Sci Rep. 2018;8:10703 pubmed publisher
    b>Slc39a8 encodes ZIP8, a divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cells, and therefore ubiquitous in adult tissues; ZIP8 influxes Zn2+, Mn2+ and Fe2+...
  17. Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller Nurasyid M, et al. Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. PLoS ONE. 2017;12:e0172995 pubmed publisher
    ..01). The lead-SNVs at novel loci are common and located in TTN, SLC39A8, MLIP, FLNC, ALPK3 and FHOD3...
  18. Galvez Peralta M, Wang Z, Bao S, Knoell D, Nebert D. Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals. Int J Toxicol. 2014;33:246-258 pubmed
    Mouse Slc39a8 and Slc39a14 genes encode ZIP8 and ZIP14, respectively, which are ubiquitous divalent cation/(HCO3-)2 symporters responsible for uptake of Zn2+, Fe2+, and Mn2+
  19. Kraja A, Chasman D, North K, Reiner A, Yanek L, Kilpeläinen T, et al. Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab. 2014;112:317-38 pubmed publisher
    ..They map to genes MACF1, KIAA0754, GCKR, GRB14, COBLL1, LOC646736-IRS1, SLC39A8, NELFE, SKIV2L, STK19, TFAP2B, BAZ1B, BCL7B, TBL2, MLXIPL, LPL, TRIB1, ATXN2, HECTD4, PTPN11, ZNF664, PDXDC1, FTO,..
  20. Jarosz M, Olbert M, Wyszogrodzka G, Młyniec K, Librowski T. Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling. Inflammopharmacology. 2017;25:11-24 pubmed publisher
    ..mechanism is initiated by the inhibition of cyclic nucleotide phosphodiesterase, whereas another presumed mechanism consists in inhibition of IκB kinase in response to infection by zinc ions that have been imported into cells by ZIP8.
  21. Coffey R, Knutson M. The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human ?-cells. Am J Physiol Cell Physiol. 2017;312:C169-C175 pubmed publisher
    ..present study, we assessed the contribution of the metal-ion transporters ZRT/IRT-like protein 14 and 8 (ZIP14 and ZIP8) and divalent metal-ion transporter-1 (DMT1) to iron uptake by human ?-cells...
  22. Giacconi R, Costarelli L, Malavolta M, Cardelli M, Galeazzi R, Piacenza F, et al. Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation. Biofactors. 2015;41:414-23 pubmed publisher
    ..plasma levels associated with decreased free cytosolic zinc in PBMCs and an upregulation of zinc transporters ZIP2, ZIP8, and Znt1...
  23. Lin W, Vann D, Doulias P, Wang T, Landesberg G, Li X, et al. Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. J Clin Invest. 2017;127:2407-2417 pubmed publisher
    Genetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus are associated with the regulation of whole-blood manganese (Mn) and multiple physiological traits...
  24. Choi E, Nguyen T, Gupta N, Iwase S, Seo Y. Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Sci Rep. 2018;8:3163 pubmed publisher
    b>SLC39A8 encodes ZIP8, a divalent metal ion transporter. Mutations in the SLC39A8 gene are associated with congenital disorder of glycosylation type II and Leigh syndrome...
  25. Amos Kroohs R, Bloor C, Qureshi M, Vorhees C, Williams M. Effects of developmental exposure to manganese and/or low iron diet: Changes to metal transporters, sucrose preference, elevated zero-maze, open-field, and locomotion in response to fenfluramine, amphetamine, and MK-801. Toxicol Rep. 2015;2:1046-1056 pubmed
    ..transporters and receptors (divalent metal transporter-1 (DMT1), transferrin (Tf), transferrin receptor (TfR), and zip8 (zrt8)) were quantified in brain at P28...
  26. Lindén M, Ramírez Sepúlveda J, James T, Thorlacius G, Brauner S, Gomez Cabrero D, et al. Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms. Biol Sex Differ. 2017;8:34 pubmed publisher
    ..regulated expression in females compared to males, depending on the genotype of SLE/pSS-associated SNPs: SLC39A8 (BANK1 locus), CD74 (TNIP1 locus), PXK, CTSB (BLK/FAM167A locus), ARCN1 (CXCR5 locus), and DHX9 (NCF2 locus)...
  27. Florea D, Molina López J, Hogstrand C, Lengyel I, de la Cruz A, Rodríguez Elvira M, et al. Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS). J Trace Elem Med Biol. 2018;49:202-209 pubmed publisher
    ..05) with zinc plasma levels, and zinc transporters ZIP3, ZIP4, ZIP8, ZnT6, ZnT7...
  28. Szeliga M, Różycka A, Jędrak P, Barańska S, Janik P, Jamrozik Z, et al. Expression of RNAs Coding for Metal Transporters in Blood of Patients with Huntington's Disease. Neurochem Res. 2016;41:101-6 pubmed publisher
    ..No changes were found in the levels of TFRC coding for TFR and SLC39A8 coding for ZIP8 between HD patients and controls...
  29. Martí Sánchez L, Ortigoza Escobar J, Darling A, Villaronga M, Baide H, Molero Luís M, et al. Hypermanganesemia due to mutations in SLC39A14: further insights into Mn deposition in the central nervous system. Orphanet J Rare Dis. 2018;13:28 pubmed publisher
    The SLC39A14, SLC30A10 and SLC39A8 are considered to be key genes involved in manganese (Mn) homeostasis in humans. Mn levels in plasma and urine are useful tools for early recognition of these disorders...
  30. Raymond A, Gekonge B, Giri M, Hancock A, Papasavvas E, Chehimi J, et al. Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia. J Leukoc Biol. 2010;88:589-96 pubmed publisher
    ..Circulating monocytes from HIV+ donors were also found to have elevated zinc importer gene Zip8 expression in conjunction with elevated intracellular zinc levels in contrast to CD4(+)T-lymphocytes...
  31. Choi W, Chun J. Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice. Osteoarthritis Cartilage. 2017;25:401-405 pubmed publisher
    ..DMM) or intra-articular (IA) injection of adenoviruses expressing hypoxia-inducible factor (HIF)-2α (Ad-Epas1), ZIP8 (Ad-Zip8), or LCN2 (Ad-Lcn2)...
  32. Lee M, Won Y, Shin Y, Kim J, Chun J. Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis. Osteoarthritis Cartilage. 2016;24:134-45 pubmed publisher
    Hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis in chondrocytes serve as catabolic regulators of osteoarthritic cartilage destruction by regulating the expression of catabolic factor genes...
  33. Pyle C, Akhter S, Bao S, Dodd C, Schlesinger L, Knoell D. Zinc Modulates Endotoxin-Induced Human Macrophage Inflammation through ZIP8 Induction and C/EBP? Inhibition. PLoS ONE. 2017;12:e0169531 pubmed publisher
    ..Zinc is an essential micronutrient used in host defense. The zinc importer ZIP8 is uniquely induced through stimulation of the NF-?B pathway by LPS in monocytes and functions to regulate ..
  34. Kim G, Shin K, Pae E. Zinc Up-Regulates Insulin Secretion from β Cell-Like Cells Derived from Stem Cells from Human Exfoliated Deciduous Tooth (SHED). Int J Mol Sci. 2016;17: pubmed
    ..Using SHED, we examined the roles of zinc and the zinc uptake transporter ZIP8 (Zrt- and irt-like protein 8) while inducing SHED into insulin secreting β cell-like stem cells (i.e...
  35. Park J, Hogrebe M, Grüneberg M, DuChesne I, von der Heiden A, Reunert J, et al. SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation. Am J Hum Genet. 2015;97:894-903 pubmed publisher
    b>SLC39A8 is a membrane transporter responsible for manganese uptake into the cell...
  36. Hennigar S, Kelley A, McClung J. Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review. Adv Nutr. 2016;7:735-46 pubmed publisher
    ..ZIP) 1 [solute carrier family (SLC) 39A1], ZIP3 (SLC39A3), ZIP5 (SLC39A5), ZIP6 (SLC39A6), ZIP7 (SLC39A7), ZIP8 (SLC39A8), ZIP10 (SLC39A10), ZIP14 (SLC39A14), zinc transporter (ZnT)1 (SLC30A1), ZnT2 (SLC30A2), ZnT4 (SLC30A4), ZnT5 (..
  37. Mak A, White M, Eckalbar W, Szpiech Z, Oh S, Pino Yanes M, et al. Whole Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma. Am J Respir Crit Care Med. 2018;: pubmed publisher
    ..The SNP is also an expression quantitative trait locus (eQTL) for a neighboring gene, SLC39A8. The lack of other asthma study populations with BDR and WGS data on minority children makes it impossible to ..
  38. Vinatier C, Merceron C, Guicheux J. Osteoarthritis: from pathogenic mechanisms and recent clinical developments to novel prospective therapeutic options. Drug Discov Today. 2016;21:1932-1937 pubmed publisher
    ..of pathogenic factors [hypoxia-inducible factors (HIFs), complement, transforming growth factor (TGF)-? and zinc-ZIP8]...
  39. Jaeken J, Peanne R. What is new in CDG?. J Inherit Metab Dis. 2017;40:569-586 pubmed publisher
    ..It expands on 23 novel CDG namely defects in SLC39A8, CAD, NANS, PGM3, SSR4, POGLUT1, NUS1, GANAB, PIGY, PIGW, PIGC, PIGG, PGAP1, PGAP3, VPS13B, CCDC115, TMEM199, ..
  40. Engelken J, Espadas G, Mancuso F, Bonet N, Scherr A, Jímenez Álvarez V, et al. Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver. Mol Biol Evol. 2016;33:738-54 pubmed publisher
    ..pair) and significant evidence for selective sweeps involving QTLs at GPX1, SELENBP1, GPX3, SLC30A9, and SLC39A8. Overall, this detailed study of various molecular phenotypes illustrates the role of regulatory variants in ..
  41. Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello M, Bowman A, et al. Manganese homeostasis in the nervous system. J Neurochem. 2015;134:601-10 pubmed publisher
    ..including transmembrane importers (divalent metal transporter 1, transferrin and its receptor, zinc transporters ZIP8 and Zip14, dopamine transporter, calcium channels, choline transporters and citrate transporters) and exporters (..
  42. Malfait A. Osteoarthritis year in review 2015: biology. Osteoarthritis Cartilage. 2016;24:21-6 pubmed publisher
    ..Highlights include a homeostatic role for CXC chemokines in cartilage, identification of the zinc-ZIP8-MTF1 axis as an essential regulator of cartilage catabolism, and the discovery that a small aggrecan fragment can ..
  43. Lin W, Li D, Cheng L, Li L, Liu F, Hand N, et al. Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. J Clin Invest. 2018;128:826-833 pubmed publisher
    ..In an attempt to characterize solute carrier family 39 member 8-null (Slc39a8-null) mice, we discovered that homozygous null embryos do not survive embryogenesis and exhibit a cardiac ..
  44. Wu Y, Lin Y, Chuang H. Laminarin modulates the chloroplast antioxidant system to enhance abiotic stress tolerance partially through the regulation of the defensin-like gene expression. Plant Sci. 2016;247:83-92 pubmed publisher
    ..Lam induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast ..
  45. Shi L, Zhang L, Li C, Hu X, Wang X, Huang Q, et al. Dietary zinc deficiency impairs humoral and cellular immune responses to BCG and ESAT-6/CFP-10 vaccination in offspring and adult rats. Tuberculosis (Edinb). 2016;97:86-96 pubmed publisher
    ..Decreased INF-γ and TNF-α production in plasma, changes of expression level of ZIP2, ZIP8, NF-κB and IL-6 mRNA in immune organs, together with reduced T cell proliferation was observed in pups and adult ..
  46. Olgar Y, Durak A, Tuncay E, Bitirim C, Ozcinar E, Inan M, et al. Increased free Zn2+ correlates induction of sarco(endo)plasmic reticulum stress via altered expression levels of Zn2+ -transporters in heart failure. J Cell Mol Med. 2018;22:1944-1956 pubmed publisher
    ..We first showed localizations of ZIP8, ZIP14 and ZnT8 to both sarcolemma and S(E)R in ventricular cardiomyocytes (H9c2 cells) using confocal together ..
  47. Clayton P. Inherited disorders of transition metal metabolism: an update. J Inherit Metab Dis. 2017;40:519-529 pubmed publisher
    ..will address: i) the manganese/zinc transporters (because two new treatable disorders were described in 2016 - SLC39A8 deficiency and SLC39A14 deficiency); ii) copper transporter disorders because we need to improve the treatment of ..
  48. Koike A, Sou J, Ohishi A, Nishida K, Nagasawa K. Inhibitory effect of divalent metal cations on zinc uptake via mouse Zrt-/Irt-like protein 8 (ZIP8). Life Sci. 2017;173:80-85 pubmed publisher
    There is controversy regarding the substrate specificity of ZIP8, a ZIP isoform, involved in regulation of extra- and intracellular zinc levels...
  49. Olgar Y, Ozdemir S, Turan B. Induction of endoplasmic reticulum stress and changes in expression levels of Zn2+-transporters in hypertrophic rat heart. Mol Cell Biochem. 2018;440:209-219 pubmed publisher
    ..also for the first time, determined significantly increased ZIP7, ZIP14, and ZnT8 expressions along with decreased ZIP8 and ZnT7 levels in the heart tissue from TAC-group in comparison to SHAM-group...
  50. Rentschler G, Kippler M, Axmon A, Raqib R, Skerfving S, Vahter M, et al. Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes. Metallomics. 2014;6:885-91 pubmed publisher
    ..To evaluate the potential effect of variation in Zn-transporter genes (SLC39A8 and SLC39A14) on Cd concentrations in blood and urine...
  51. Jobarteh M, McArdle H, Holtrop G, Sise E, Prentice A, Moore S. mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status. J Nutr. 2017;147:1401-1409 pubmed publisher
    ..mRNA levels for intracellular zinc-uptake proteins, in this case zrt, irt-like protein (ZIP) 4 and ZIP8, were 96-205% lower in the PE+MMN arm than in the intervention arms without added zinc (P < 0.025)...
  52. Nishikawa M, Mori H, Hara M. Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural stem/progenitor cells. Environ Toxicol Pharmacol. 2017;53:81-88 pubmed publisher
    ..Expression of Zip4 and that of Zip12 drastically increased, while that of Zip8 clearly decreased after differentiation of NSPCs...
  53. Girijashanker K, He L, Soleimani M, Reed J, Li H, Liu Z, et al. Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Mol Pharmacol. 2008;73:1413-23 pubmed publisher
    ..Viewed from an evolutionary perspective, SLC39A14 and SLC39A8 are the most closely related, each having three noncoding exons 1...
  54. Thevenod F. Catch me if you can! Novel aspects of cadmium transport in mammalian cells. Biometals. 2010;23:857-75 pubmed publisher
    ..Apart from transport by the ZIP transporters SLC39A8 and SLC39A14, which is not topic of the review, uptake of free Cd(2+) has been demonstrated for the Fe(2+)/H(+) ..
  55. Januchowski R, Zawierucha P, Rucinski M, Andrzejewska M, Wojtowicz K, Nowicki M, et al. Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. Biomed Pharmacother. 2014;68:447-53 pubmed publisher
    ..Five genes were significantly upregulated: SLC2A9, SLC16A3, SLC16A14, SLC38A4 and SLC39A8. Four additional genes were significantly downregulated: SLC2A14, SLC6A15, SLC8A1 and SLC27A2...
  56. Zhang R, Witkowska K, Afonso Guerra Assunção J, Ren M, Ng F, Mauro C, et al. A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity. Hum Mol Genet. 2016;25:4117-4126 pubmed publisher
    ..between inter-individual variation in blood pressure and the single nucleotide polymorphism rs13107325 in the SLC39A8 gene...
  57. Boycott K, Beaulieu C, Kernohan K, Gebril O, Mhanni A, Chudley A, et al. Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8. Am J Hum Genet. 2015;97:886-93 pubmed publisher
    ..112G>C (p.Gly38Arg), affecting a conserved residue of SLC39A8. The affected Hutterite and Egyptian individuals did not share an extended common haplotype, suggesting that the ..
  58. Ng E, Lind P, Lindgren C, Ingelsson E, Mahajan A, Morris A, et al. Genome-wide association study of toxic metals and trace elements reveals novel associations. Hum Mol Genet. 2015;24:4739-45 pubmed publisher
    ..1 × 10(-11), β = -0.77), located in an exon of SLC39A8, which encodes a protein involved in manganese and zinc transport...
  59. Sterling J, Guttha S, Song Y, Song D, Hadziahmetovic M, Dunaief J. Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. Exp Eye Res. 2017;155:15-23 pubmed publisher
    ..RT-PCR and Western analysis were used to quantify the expression of three ferrous iron importers, Dmt1, Zip8, and Zip14, in wild-type (Wt), Cp/Heph DKO, and Hepc KO retinas...
  60. Wahlberg K, Arora M, Curtin A, Curtin P, Wright R, Smith D, et al. Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth. Neurotoxicology. 2018;64:103-109 pubmed publisher
    ..We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life...
  61. Aydemir T, Liuzzi J, McClellan S, Cousins R. Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells. J Leukoc Biol. 2009;86:337-48 pubmed publisher
    The zinc transporter ZIP8 is highly expressed in T cells derived from human subjects. T cell ZIP8 expression was markedly up-regulated upon in vitro activation...
  62. Song J, Kim D, Lee C, Lee M, Chun C, Jin E. MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis. J Biomed Sci. 2013;20:31 pubmed publisher
    ..Target validation study showed that miR-488 targets ZIP8 and suppression of ZIP8 in OA animal model showed the reduced cartilage degradation...
  63. Wang C, Jenkitkasemwong S, Duarte S, Sparkman B, Shawki A, Mackenzie B, et al. ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. J Biol Chem. 2012;287:34032-43 pubmed publisher
    ZIP8 (SLC39A8) belongs to the ZIP family of metal-ion transporters. Among the ZIP proteins, ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and cadmium...
  64. Taylor K, Morgan H, Johnson A, Hadley L, Nicholson R. Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. Biochem J. 2003;375:51-9 pubmed
    ..Combining the crucial role that zinc plays in cell growth and the proven role of metalloproteases in metastasis presents an exciting indication of how LIV-1 plays a role in breast cancer progression. ..
  65. Johansson Ã, Eriksson N, Lindholm D, Varenhorst C, James S, Syvänen A, et al. Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome. Hum Mol Genet. 2016;25:1447-56 pubmed publisher
    ..Genetic variants at two novel loci (SLC39A8 and POC1B/GALNT4) were associated with NT-proBNP levels and replicated together with the previously known NPPB ..
  66. Riley L, Cowley M, Gayevskiy V, Roscioli T, Thorburn D, Prelog K, et al. A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders. J Inherit Metab Dis. 2017;40:261-269 pubmed publisher
    b>SLC39A8 variants have recently been reported to cause a type II congenital disorder of glycosylation (CDG) in patients with intellectual disability and cerebellar atrophy...
  67. Taylor K, Nicholson R. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim Biophys Acta. 2003;1611:16-30 pubmed
    ..These differences to other zinc transporters may be consistent with an alternative role for LZT proteins in cells, particularly in diseases such as cancer. ..
  68. Zhu Q, Guo S, Yuan S, Lv Z, Zheng J, Xia H. Heat indicators of oxidative stress, inflammation and metal transport show dependence of cadmium pollution history in the liver of female zebrafish. Aquat Toxicol. 2017;191:1-9 pubmed publisher
    ..of IL-6, IL-1?, TNF-?, iNOS and NF-?B), 8 molecular indicators of metal transport (mRNA levels of, ZnT1, ZnT5, ZIP8, ZIP10, ATP7A, ATP7B and CTR1). All biochemical indicators were unchanged in group 1 and changed in group 2 and 3...
  69. Pyle C, Azad A, Papp A, Sadee W, Knoell D, Schlesinger L. Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis. Int J Mol Sci. 2017;18: pubmed publisher
    ..In particular, the human zinc transporter Zrt-/Irt-like protein 8 (ZIP8), one of 14 ZIP family members, is important in the flux of divalent cations, including zinc, into the cytoplasm of ..
  70. Liu M, Bao S, Galvez Peralta M, Pyle C, Rudawsky A, Pavlovicz R, et al. ZIP8 regulates host defense through zinc-mediated inhibition of NF-?B. Cell Rep. 2013;3:386-400 pubmed publisher
    ..Herein, we report that the zinc transporter SLC39A8 (ZIP8) is a transcriptional target of NF-?B and functions to negatively regulate proinflammatory responses ..
  71. Carrera N, Arrojo M, Sanjuan J, Ramos Ríos R, Paz E, Suárez Rama J, et al. Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. Biol Psychiatry. 2012;71:169-77 pubmed publisher
    ..One SNP, rs13107325, located at the metal ions transporter gene SLC39A8, reached significance in the combined sample after Bonferroni correction (trend test, p = 2...
  72. Fujishiro H, Hamao S, Tanaka R, Kambe T, Himeno S. Concentration-dependent roles of DMT1 and ZIP14 in cadmium absorption in Caco-2 cells. J Toxicol Sci. 2017;42:559-567 pubmed publisher
    ..The roles of zinc transporters such as ZIP8 and ZIP14 remain unclear, and the roles of these four transporters in the intestinal uptake of Cd under ..
  73. Besecker B, Bao S, Bohacova B, Papp A, Sadee W, Knoell D. The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia. Am J Physiol Lung Cell Mol Physiol. 2008;294:L1127-36 pubmed publisher
    ..While many zinc transporters were constitutively expressed, only SLC39A8 (Zip8) mRNA was strongly induced by TNF-alpha...
  74. Begum N, Kobayashi M, Moriwaki Y, Matsumoto M, Toyoshima K, Seya T. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. Genomics. 2002;80:630-45 pubmed
    ..In fact, increased accumulation of intracellular Zn(2+) was observed due to the expression of BIGM103 in CHO cells...
  75. Fujihara J, Yasuda T, Kimura Kataoka K, Takinami Y, Nagao M, Takeshita H. Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans. Leg Med (Tokyo). 2018;30:28-33 pubmed publisher
    ..Among the 20 SNPs examined, 3 SNPs (SLC30A3 rs11126936, SLC39A8 rs233804, and SLC39A14 rs4872479) were significantly associated with blood zinc concentration...
  76. Sun P, Wang S, Jiang Y, Tao Y, Tian Y, Zhu K, et al. Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature. Biol Trace Elem Res. 2013;155:11-22 pubmed publisher
    ..Zip2, Zip6, and ZnT1 mRNA were associated with zinc level in established human breast cancer in nude mice model; Zip8 was significantly lower in zinc-deficient Wistar rats in kidney...
  77. Zogzas C, Mukhopadhyay S. Inherited Disorders of Manganese Metabolism. Adv Neurobiol. 2017;18:35-49 pubmed publisher
    ..metabolism have now been described - mutations in SLC39A14 cause manganese toxicity, while mutations in SLC39A8 cause manganese and zinc deficiency...
  78. Guo S, Zheng J, Yuan S, Zhu Q. Effects of heat and cadmium exposure on stress-related responses in the liver of female zebrafish: Heat increases cadmium toxicity. Sci Total Environ. 2018;618:1363-1370 pubmed publisher
    ..Finally, heat down-regulated Zir-, Irt-like protein 8 (ZIP8) and copper transporter 1 (CTR1) and up-regulated metallothioneins (MTs) in Cd-exposed fish, possibly suggesting Cu ..
  79. Baumann B, Sterling J, Song Y, Song D, Fruttiger M, Gillies M, et al. Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation. Invest Ophthalmol Vis Sci. 2017;58:4223-4234 pubmed publisher
    ..There were corresponding changes in mRNA and/or protein levels of ferritin, transferrin receptor, ferroportin, Zip8, and Zip14...
  80. Aiba I, Hossain A, Kuo M. Elevated GSH level increases cadmium resistance through down-regulation of Sp1-dependent expression of the cadmium transporter ZIP8. Mol Pharmacol. 2008;74:823-33 pubmed publisher these GCLC-transfected cell lines, which were associated with down-regulation of the cadmium transporter ZIP8/SLC39A8. Further analyses demonstrated that Sp1 binding site at the proximal promoter region of ZIP8 was sensitive to the ..
  81. Wang X, Ning Y, Yang L, Yu F, Guo X. Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium. Biol Trace Elem Res. 2017;179:178-184 pubmed publisher
    ..The zinc-ZIP8-MTF1 axis in chondrocytes forms a catabolic cascade that promotes upregulation of the crucial effector matrix-..
  82. Li M, Wu D, Yao Y, Huo Y, Liu J, Su B, et al. Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans. Schizophr Bull. 2016;42:178-90 pubmed publisher
    ..0 × 10(-8) in Europeans) in the SLC39A8 gene...
  83. Li D, Achkar J, Haritunians T, Jacobs J, Hui K, D Amato M, et al. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016;151:724-32 pubmed publisher
    ..encoding alanine or threonine at position 391 in the zinc transporter solute carrier family 39, member 8 protein (SLC39A8 alanine 391 threonine, rs13107325) and replicated the association with CD in 2 replication cohorts (combined meta-..