SLC38A4

Summary

Gene Symbol: SLC38A4
Description: solute carrier family 38 member 4
Alias: ATA3, NAT3, PAAT, SNAT4, sodium-coupled neutral amino acid transporter 4, N amino acid transporter 3, Na(+)-coupled neutral amino acid transporter 4, amino acid transporter A3, amino acid transporter system A3, system A amino acid transporter 3, system N amino acid transporter 3
Species: human
Products:     SLC38A4

Top Publications

  1. Hatanaka T, Huang W, Ling R, Prasad P, Sugawara M, Leibach F, et al. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta. 2001;1510:10-7 pubmed
    ..and functional characterization of the third subtype of amino acid transport system A, designated ATA3 (amino acid transporter A3), from a human liver cell line...
  2. Gu S, Adan Rice D, Leach R, Jiang J. A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics. 2001;74:262-72 pubmed
    ..The data obtained in this study are likely to offer critical clues for identification of amino acid transporter-associated diseases. ..
  3. Mackenzie B, Erickson J. Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch. 2004;447:784-95 pubmed
    ..Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive...
  4. Desforges M, Lacey H, Glazier J, Greenwood S, Mynett K, Speake P, et al. SNAT4 isoform of system A amino acid transporter is expressed in human placenta. Am J Physiol Cell Physiol. 2006;290:C305-12 pubmed
    ..Slc38 gene family, giving rise to three subtypes: Na+-coupled neutral amino acid transporter (SNAT)1, SNAT2, and SNAT4. SNAT2 is expressed ubiquitously in mammalian tissues; SNAT1 is predominantly expressed in heart, brain, and ..
  5. Hirose M, Hada M, Kamimura S, Matoba S, Honda A, Motomura K, et al. Aberrant imprinting in mouse trophoblast stem cells established from somatic cell nuclear transfer-derived embryos. Epigenetics. 2018;13:693-703 pubmed publisher
    ..Placenta-specific maternally imprinted genes (Gab1, Slc38a4, and Sfmbt2) consistently showed biallelic expression in SCNT-TSCs, suggesting their loss of imprinting (LOI)...
  6. Zattas D, Adle D, Rubenstein E, Hochstrasser M. N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Mol Biol Cell. 2013;24:890-900 pubmed publisher
    ..We previously found that deletion of the gene (NAT3) encoding the catalytic subunit of the NatB N-terminal acetyltransferase weakly stabilized a Deg1-fusion protein...
  7. Habash S, Laser K, Moosmann J, Reif R, Adler W, Glöckler M, et al. Normal values of the pulmonary artery acceleration time (PAAT) and the right ventricular ejection time (RVET) in children and adolescents and the impact of the PAAT/RVET-index in the assessment of pulmonary hypertension. Int J Cardiovasc Imaging. 2019;35:295-306 pubmed publisher
    New echocardiographic modalities including pulmonary artery acceleration time (PAAT) and right ventricular ejection time (RVET) are evolving to facilitate an early non-invasive diagnosis for pulmonary hypertension (PH) in adults...
  8. Li M, Lu X, Xia H, Zhang C, Wang X, Chen Z, et al. In-depth characterization of the pituitary transcriptome in Simmental and Chinese native cattle. Domest Anim Endocrinol. 2019;66:35-42 pubmed publisher
    ..Our findings demonstrated that SYTL2, SLC38A4, and NCAM2 are new candidates for crucial functions in the secretory pathways of the pituitary gland...
  9. Ma S, Wang X, Yao J, Cao Q, Zuo X. Roles of apoptosis and inflammation in a rat model of acute lung injury induced right ventricular dysfunction. Biomed Pharmacother. 2018;108:1105-1114 pubmed publisher
    ..Echocardiography examined pulmonary artery acceleration time (PAAT), right ventricular free wall thickness (RVFWT), tricuspid annular plane systolic excursion (TAPSE), and right ..

More Information

Publications40

  1. Bussmann N, El Khuffash A, Breatnach C, McCallion N, Franklin O, Singh G, et al. Left ventricular diastolic function influences right ventricular - Pulmonary vascular coupling in premature infants. Early Hum Dev. 2019;128:35-40 pubmed publisher
    ..relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration time [PAAT] ratio)...
  2. Xin W, Li Q, Fang L, Zhong L, Zheng X, Huang P. Preventive Effect and Mechanism of Ethyl Acetate Extract of Sceptridium ternatum in Monocrotaline-Induced Pulmonary Arterial Hypertension. Chin J Integr Med. 2018;: pubmed publisher
    ..right ventricle (RV), and lung index (LI), while a signififi cant decrease in pulmonary artery acceleration time (PAAT, P<0.01)...
  3. Monnier P, Martinet C, Pontis J, Stancheva I, Ait Si Ali S, Dandolo L. H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1. Proc Natl Acad Sci U S A. 2013;110:20693-8 pubmed publisher
    ..For three of these genes--Igf2 (insulin-like growth factor 2), Slc38a4 (solute carrier family 38 member 4), and Peg1 (paternally expressed gene 1)--both MBD1 and H3K9me3 binding were ..
  4. Jain A, Mohamed A, Kavanagh B, Shah P, Kuipers B, El Khuffash A, et al. Cardiopulmonary Adaptation During First Day of Life in Human Neonates. J Pediatr. 2018;200:50-57.e2 pubmed publisher
    ..Specifically, assessment of pulmonary vascular resistance (PVR) (pulmonary artery acceleration time [PAAT], right ventricular ejection time, right ventricular ejection time:PAAT [PVR index], and PAAT indexed to heart rate ..
  5. Niopek Witz S, Deppe J, Lemieux M, Möhlmann T. Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana. Biochim Biophys Acta. 2014;1838:3025-35 pubmed publisher
    ..We present the biochemical characterization of two NAT proteins, NAT3 and NAT12 from Arabidopsis thaliana after their heterologous expression in Escherichia coli UraA knockout mutants...
  6. Laurieri N, Kawamura A, Westwood I, Varney A, Morris E, Russell A, et al. Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding. BMC Pharmacol Toxicol. 2014;15:68 pubmed publisher
    The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans...
  7. Xu D, Zhang C, Li J, Wang G, Chen W, Li D, et al. Polymorphic Imprinting of SLC38A4 Gene in Bovine Placenta. Biochem Genet. 2018;56:639-649 pubmed publisher
    ..The slc38a4 gene encodes a neutral amino acid transporter and is identified as imprinted in mice...
  8. Levy P, Patel M, Choudhry S, Hamvas A, Singh G. Evidence of Echocardiographic Markers of Pulmonary Vascular Disease in Asymptomatic Infants Born Preterm at One Year of Age. J Pediatr. 2018;197:48-56.e2 pubmed publisher
    ..Pulmonary artery acceleration time (PAAT), a validated index of pulmonary vascular resistance, arterial pressure, and compliance, was used to assess ..
  9. Lee S, Ye A, Kim J. DNA-Binding Motif of the Imprinted Transcription Factor PEG3. PLoS ONE. 2015;10:e0145531 pubmed publisher
    ..Among the newly identified targets, we analyzed in detail the two loci, Slc38a2 and Slc38a4, which are known to be involved in neutral amino acid transport...
  10. Dahhan T, Siddiqui I, Tapson V, Velazquez E, Sun S, Davenport C, et al. Clinical and echocardiographic predictors of mortality in acute pulmonary embolism. Cardiovasc Ultrasound. 2016;14:44 pubmed
    ..area change (RVFAC), Tricuspid Annular Plane Systolic Excursion (TAPSE), pulmonary artery acceleration time (PAAT) and RV myocardial performance (Tei) index...
  11. Levy P, Patel M, Groh G, Choudhry S, Murphy J, Holland M, et al. Pulmonary Artery Acceleration Time Provides a Reliable Estimate of Invasive Pulmonary Hemodynamics in Children. J Am Soc Echocardiogr. 2016;29:1056-1065 pubmed publisher
    Pulmonary artery acceleration time (PAAT) is a noninvasive method to assess pulmonary hemodynamics, but it lacks validity in children...
  12. Lee S, Kang H, Choi J, Jung D, Lee W, Lee H, et al. Polymorphisms in cancer-related pathway genes and lung cancer. Eur Respir J. 2016;48:1184-1191 pubmed publisher
    ..rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and solute carrier family 38, member 4 (SLC38A4) rs2429467C>T) consistantly showed significant associations with lung cancer in the replication study...
  13. Bröer A, Rahimi F, Broer S. Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. J Biol Chem. 2016;291:13194-205 pubmed publisher
    ..osteosarcoma cells express a set of glutamine transporters including SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT4 (SLC38A4), LAT1 (SLC7A5), and ASCT2 (SLC1A5)...
  14. Lahbib Mansais Y, Barasc H, Marti Marimon M, Mompart F, Iannuccelli E, Robelin D, et al. Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells. BMC Cell Biol. 2016;17:35 pubmed
    ..e. SLC38A4, DLK1, MEG3, and ZAC1)...
  15. Koestenberger M, Grangl G, Avian A, Gamillscheg A, Grillitsch M, Cvirn G, et al. Normal Reference Values and z Scores of the Pulmonary Artery Acceleration Time in Children and Its Importance for the Assessment of Pulmonary Hypertension. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    Pulsed-wave Doppler determination of the pulmonary artery acceleration time (PAAT) as a surrogate for pulmonary artery pressure was found to be of clinical value for assessment of pulmonary hypertension (PH) with studies to date ..
  16. Toldo S, Mauro A, Marchetti C, Rose S, Mezzaroma E, Van Tassell B, et al. Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition. J Cardiovasc Pharmacol. 2016;68:27-32 pubmed publisher
    ..plasma protein with neutrophil elastase-inhibiting activity, and AAT is available as a plasma-derived therapeutic (pAAT). In experimental myocardial infarction, pAAT reduced acute inflammatory injury because of ischemia-reperfusion...
  17. Sharma N, Kubaczka C, Kaiser S, Nettersheim D, Mughal S, Riesenberg S, et al. Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest. Development. 2016;143:787-98 pubmed publisher
    ..Loss of TFAP2C led to upregulation of imprinted gene H19 and downregulation of Slc38a4 and Ascl2. The placental insufficiency post E16.5 causes fetal growth restriction, with 19% lighter mutant pups...
  18. de Sousa L, Mamiya A, Kjelstrup Hansen J, da Silva Filho D. A joint theoretical and experimental characterization of two acene-thiophene derivatives. J Mol Model. 2017;23:52 pubmed publisher
    ..framework to accurately characterize the optical and electronic properties of two such compounds: NaT2 and NaT3. This is done by comparing the results of simulations with experimental absorption spectra...
  19. Auclair G, Borgel J, Sanz L, Vallet J, Guibert S, Dumas M, et al. EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos. Genome Res. 2016;26:192-202 pubmed publisher
    ..EHMT2 also plays a role in the maintenance of germline-derived DNA methylation at one imprinted locus, the Slc38a4 gene. Finally, we show that DNA methylation is instrumental for EHMT2-mediated gene silencing in embryogenesis...
  20. Croft T, James Theoga Raj C, Salemi M, Phinney B, Lin S. A functional link between NAD+ homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiae. J Biol Chem. 2018;293:2927-2938 pubmed publisher
    ..Mutants lacking components of the NatB complex, NAT3 and MDM20, appeared as hits in this screen...
  21. Ma S, Wang Y, Zuo X, Yao J, Cao Q. [Effects of acute respiratory distress syndrome induced by endotoxin on the right ventricular function in rats]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:204-208 pubmed publisher
    ..artery (PAVmax), maximum pulmonary artery pressure gradient (PAmaxPG), pulmonary artery acceleration time (PAAT) and tricuspid annular plane systolic excursion (TAPSE) were decreased, with significant differences at 12 hours as ..
  22. Zeb I, Ahmadi N, Flores F, Budoff M. Randomized trial evaluating the effect of aged garlic extract with supplements versus placebo on adipose tissue surrogates for coronary atherosclerosis progression. Coron Artery Dis. 2017;: pubmed publisher
    Increased epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), periaortic adipose tissue (PaAT), and subcutaneous adipose tissue (SAT) are mediators of metabolic risk, and are associated with the severity of coronary artery ..
  23. Desforges M, Mynett K, Jones R, Greenwood S, Westwood M, Sibley C, et al. The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. J Physiol. 2009;587:61-72 pubmed publisher
    ..There are three system A isoforms: SNAT1, SNAT2 and SNAT4, but the contribution of each to system A-mediated transport is unknown...
  24. Wang Y, Huang C, Tu Y. Pulmonary Hypertension and Pulmonary Artery Acceleration Time: A Systematic Review and Meta-Analysis. J Am Soc Echocardiogr. 2017;: pubmed publisher
    ..The aim of this study was to determine whether echocardiography-derived pulmonary artery acceleration time (PAAT) possesses adequate diagnostic performance for PH, using right-heart catheterization as a reference standard.
  25. Cao Y, Matsubara T, Zhao C, Gao W, Peng L, Shan J, et al. Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment. Sci Rep. 2017;7:9307 pubmed publisher
    ..NNMT-ASO and ApoB-ASO are chemically conjugated with T3 using a non-cleavable sulfo-SMCC linker. Both NNMT-ASO-T3 (NAT3) and ApoB-ASO-T3 (AAT3) enhance thyroid hormone receptor activity...
  26. Yang X, Yang J, Li L, Sun L, Yi X, Han X, et al. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB J. 2014;28:4821-34 pubmed publisher
    ..identification and functional characterization of a novel ATPase protein, protein associated with ABC transporters (PAAT), in humans...
  27. González Renteria S, Loera Castañeda V, Chairez Hernandez I, Sosa Macias M, Paniagua Castro N, Lares Aseff I, et al. Association of the polymorphisms 292?C>T and 1304?G>A in the SLC38A4 gene with hyperglycaemia. Diabetes Metab Res Rev. 2013;29:39-43 pubmed publisher
    The SLC38A4 gene is related to system 'A' activity, which seems to be related to impaired gluconeogenesis...
  28. Shi Q, Padmanabhan R, Villegas C, Gu S, Jiang J. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. J Biol Chem. 2011;286:38086-94 pubmed publisher
    ..immunofluorescence combined with molecular modeling approaches, we resolved the membrane topological structure of SNAT4, a transporter expressed predominantly in liver...
  29. Iruloh C, D Souza S, Fergusson W, Baker P, Sibley C, Glazier J. Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. Pediatr Res. 2009;65:51-6 pubmed publisher
    ..We conclude that the reduced amino acid transporter activity found in placenta in IUGR is not a feature of all fetal cells. ..
  30. Januchowski R, Zawierucha P, Rucinski M, Andrzejewska M, Wojtowicz K, Nowicki M, et al. Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. Biomed Pharmacother. 2014;68:447-53 pubmed publisher
    ..Five genes were significantly upregulated: SLC2A9, SLC16A3, SLC16A14, SLC38A4 and SLC39A8. Four additional genes were significantly downregulated: SLC2A14, SLC6A15, SLC8A1 and SLC27A2...
  31. Schioth H, Roshanbin S, Hägglund M, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013;34:571-85 pubmed publisher
    ..PAT1 (SLC36A1), PAT2 (SLC36A2), PAT4 (SLC36A4), SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT3 (SLC38A3), and SNAT4 (SLC38A4). Here we review the structural characteristics and functional role of these transporters...