SLC38A2

Summary

Gene Symbol: SLC38A2
Description: solute carrier family 38 member 2
Alias: ATA2, PRO1068, SAT2, SNAT2, sodium-coupled neutral amino acid transporter 2, amino acid transporter 2, amino acid transporter A2, protein 40-9-1, system A amino acid transporter 2, system A transporter 1, system N amino acid transporter 2
Species: human
Products:     SLC38A2

Top Publications

  1. Jones H, Jansson T, Powell T. IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. Am J Physiol Cell Physiol. 2009;297:C1228-35 pubmed publisher
    ..In cells transfected with small interfering RNA (siRNA) targeting STAT3, the RNA and protein expression of SNAT2, but not SNAT1, was reduced and the stimulating effect of IL-6 on system A activity was abolished...
  2. Soliman A, Ahmed A, Shimamoto T, el Domany R, Nariya H, Shimamoto T. First report in Africa of two clinical isolates of Proteus mirabilis carrying Salmonella genomic island (SGI1) variants, SGI1-PmABB and SGI1-W. Infect Genet Evol. 2017;51:132-137 pubmed publisher
    ..Furthermore, PmTAN59 carried class 2 integron of ~2.2kb containing dfrA1-sat2-aadA1. An ERIC-PCR analysis detected no clonal relationship between the two strains...
  3. Dong X, Zhou Z, Wang L, Saremi B, Helmbrecht A, Wang Z, et al. Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci. 2018;101:5502-5514 pubmed publisher
    ..lowest phosphorylation of Akt and eEF2 and mRNA abundance of CSN2 and various AA transporters (SLC7A5, SLC36A1, SLC38A2, SLC38A9, SLC43A1)...
  4. Ma Y, Batistel F, Xu T, Han L, Bucktrout R, Liang Y, et al. Phosphorylation of AKT serine/threonine kinase and abundance of milk protein synthesis gene networks in mammary tissue in response to supply of methionine in periparturient Holstein cows. J Dairy Sci. 2019;102:4264-4274 pubmed publisher
    ..also upregulated mRNA abundance of high-affinity cationic (SLC7A1) and sodium-coupled AA transporters (SLC38A1, SLC38A2); leucyl-tRNA (LARS), valyl-tRNA (VARS), and isoleucyl-tRNA synthetases (IARS); glucose transport solute carrier ..
  5. Yang X, Zou W, Zeng J, Xie S, An T, Luo X, et al. Prevalence of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from yaks (Poephagus grunniens) in Aba Tibetan Autonomous Prefecture, China. Microb Pathog. 2017;111:274-279 pubmed publisher
    ..The most prevalent gene cassette was aadA1 (20%). For the class 2 integron, dfrA1-sat2-aadA1 (6%) and dfrA1-sat1-aadA1 (0.4%) were also detected as part of this research...
  6. Sagri E, Reczko M, Gregoriou M, Tsoumani K, Zygouridis N, Salpea K, et al. Olive fly transcriptomics analysis implicates energy metabolism genes in spinosad resistance. BMC Genomics. 2014;15:714 pubmed publisher
    ..Four of these loci (Yolk protein 2, ATP Synthase FO subunit 6, Low affinity cationic amino acid transporter 2 and Serine protease 6) showed consistently higher expression both in the spinosad resistant strain and in ..
  7. Stahl B, Peco E, Davla S, Murakami K, Caicedo Moreno N, van Meyel D, et al. The Taurine Transporter Eaat2 Functions in Ensheathing Glia to Modulate Sleep and Metabolic Rate. Curr Biol. 2018;28:3700-3708.e4 pubmed publisher
    ..With this approach, we identified Excitatory amino acid transporter 2 (Eaat2) and found that its loss from glia, but not neurons, increases sleep...
  8. Shi W, Xu X, Yan F, Wang B, Zhao H, Chan A, et al. N-Myc downstream-regulated gene 2 restrains glycolysis and glutaminolysis in clear cell renal cell carcinoma. Oncol Lett. 2017;14:6881-6887 pubmed publisher
    ..transporter 1, hexokinase 2, pyruvate kinase M2, lactate dehydrogenase A, glutamine transporter ASC amino acid transporter 2 and glutaminase 1 at the mRNA (by quantitative polymerase chain reaction) and protein level (by western ..
  9. Ruby C, O Connor K, Ayers Ringler J, Choi D. Adenosine and glutamate in neuroglial interaction: implications for circadian disorders and alcoholism. Adv Neurobiol. 2014;11:103-19 pubmed publisher
    ..through neuroglial interactions involving glutamate uptake transporter GLT-1 [referred to as excitatory amino acid transporter 2 (EAAT2) in human] and possibly water channel aquaporin 4 to regulate ethanol sensitivity, reward-related ..

More Information

Publications116 found, 100 shown here

  1. Koo J, Yoon J. Expression of metabolism-related proteins in lacrimal gland adenoid cystic carcinoma. Am J Clin Pathol. 2015;143:584-92 pubmed publisher
    ..transporter 4 [MCT4]), glutaminolysis (glutaminase 1 [GLS1], glutamate dehydrogenase [GDH], and amino acid transporter 2 [ASCT2]), mitochondria (adenosine triphosphate [ATP] synthase, succinate dehydrogenase A [SDHA], and ..
  2. Barat A, Sahoo P, Kumar R, Pande V. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comp Biochem Physiol B Biochem Mol Biol. 2016;200:54-61 pubmed publisher
    ..The slc15a2, slc25a47, slc33a1 and slc38a2 were highly expressed in brain and slc30a5 was over-expressed in gill...
  3. Hinson S, Clift I, Luo N, Kryzer T, Lennon V. Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor. Proc Natl Acad Sci U S A. 2017;114:5491-5496 pubmed publisher
    ..Interaction of the IgG-AQP4 complex with Fc?Rs triggers coendocytosis of the excitatory amino acid transporter 2 (EAAT2)...
  4. Su L, Xu Q, Zhang P, Michalek S, Katz J. Phenotype and Function of Myeloid-Derived Suppressor Cells Induced by Porphyromonas gingivalis Infection. Infect Immun. 2017;85: pubmed publisher
    ..responses required T cell-MDSC contact and was mediated by inducible nitric oxide synthase and cationic amino acid transporter 2 via gamma interferon...
  5. Hinton D, Lee M, Jang J, Choi D. Type 1 equilibrative nucleoside transporter regulates astrocyte-specific glial fibrillary acidic protein expression in the striatum. Brain Behav. 2014;4:903-14 pubmed publisher
    ..Previously, we found that astrocytic excitatory amino acid transporter 2 (EAAT2) and aquaporin 4 (AQP4) are downregulated in the striatum of mice lacking type 1 equilibrative ..
  6. Zhou X, Wang X, Yang Y, Luo J, Dong H, Liu Y, et al. Biomarkers related with seizure risk in glioma patients: A systematic review. Clin Neurol Neurosurg. 2016;151:113-119 pubmed publisher
    ..Genetic biomarkers such as isocitrate dehydrogenase 1 (IDH1) mutations, low expression of excitatory amino acid transporter 2 (EAAT2), high xCT expression, overexpression of adenosine kinase (ADK) and low expression of very large G-..
  7. Duval F, Santos E, Poidatz D, Serazin V, Gronier H, Vialard F, et al. Adiponectin Inhibits Nutrient Transporters and Promotes Apoptosis in Human Villous Cytotrophoblasts: Involvement in the Control of Fetal Growth. Biol Reprod. 2016;94:111 pubmed publisher
    ..of the major glucose transporters (GLUT1 and GLUT12) and sodium-coupled neutral amino acid transporters (SNAT1, SNAT2, and SNAT4), 2) enhances total ATP production but decreases lactate production, 3) inhibits mitochondrial ..
  8. Liong S, Lappas M. Lipopolysaccharide and double stranded viral RNA mediate insulin resistance and increase system a amino acid transport in human trophoblast cells in vitro. Placenta. 2017;51:18-27 pubmed publisher
    ..LPS and poly(I:C) also significantly increased expression of System A amino acid transporters SNAT1 and SNAT2, and System A-mediated uptake of amino acids...
  9. Wu H, Xia S, Bu F, Qi J, Liu Y, Xu H. Identification of integrons and phylogenetic groups of drug-resistant Escherichia coli from broiler carcasses in China. Int J Food Microbiol. 2015;211:51-6 pubmed publisher
    ..and dfrA12-orfF-aadA2 in the variable region of class 1 integrons, while only one gene cassette array (dfrA1-sat2-aadA1) was detected in the variable region of class 2 integrons...
  10. Awad A, Arafat N, Elhadidy M. Genetic elements associated with antimicrobial resistance among avian pathogenic Escherichia coli. Ann Clin Microbiol Antimicrob. 2016;15:59 pubmed
    ..dfrA1, dfrA5, dfrA7, dfrA12), streptomycin/spectinomycin (aadA1, aadA2, aadA5, aadA23), and streptothricin (sat2). To our knowledge, this the first description of the presence of aadA23 in APEC isolates...
  11. Zou W, Li C, Yang X, Wang Y, Cheng G, Zeng J, et al. Frequency of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from giant pandas (Ailuropoda melanoleuca) in China. Microb Pathog. 2018;116:173-179 pubmed publisher
    ..However, only one gene cassette (dfrA1-sat2-aadA1) was detected in class 2 integron. These finding emphasize that a high level of E...
  12. Dong X, Zhou Z, Saremi B, Helmbrecht A, Wang Z, Loor J. Varying the ratio of Lys:Met while maintaining the ratios of Thr:Phe, Lys:Thr, Lys:His, and Lys:Val alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci. 2018;101:1708-1718 pubmed publisher
    ..5. However, compared with IPAA, mRNA expression of ?-casein and AA transporters (SLC7A5, SLC36A1, SLC38A2, SLC38A9, and SLC43A1) and mTOR phosphorylation were lower in response to LM2.5 and LM2.0...
  13. Xu X, Li J, Sun X, Guo Y, Chu D, Wei L, et al. Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. Oncotarget. 2015;6:26161-76 pubmed publisher
  14. Dang D, Shin E, Tran H, Kim D, Jeong J, Jang C, et al. The role of system Xc- in methamphetamine-induced dopaminergic neurotoxicity in mice. Neurochem Int. 2017;108:254-265 pubmed publisher
    ..Our results suggest that Sxc mediates MA-induced neurotoxicity via facilitating oxidative stress, microgliosis, proapoptosis, and glutamate-related toxicity. ..
  15. Gürke J, Schindler M, Pendzialek S, Thieme R, Grybel K, Heller R, et al. Maternal diabetes promotes mTORC1 downstream signalling in rabbit preimplantation embryos. Reproduction. 2016;151:465-76 pubmed publisher
    ..initiation (eukaryotic translation initiation factor 4E; EIF4E), amino acid transport (large neutral amino acid transporter 2; Lat2: gene SLC7A8) and proliferation (proliferating cell nuclear antigen; PCNA) in a mTORC1-dependent ..
  16. Geis C, Ritter C, Ruschil C, Weishaupt A, Grünewald B, Stoll G, et al. The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. Exp Neurol. 2015;265:8-21 pubmed publisher
    ..Immunoreactivity to AQP4 and to the excitatory amino acid transporter 2 (EAAT2) was markedly reduced whereas immunoreactivity to the astrocytic marker glial fibrillary acid ..
  17. Ling W, Chen M, Zhang Y, Ou M, Gu L. Study on ceramide modulates EAAT-2 participation in the immunoinflammatory response in schizophrenia. Eur Rev Med Pharmacol Sci. 2019;23:2263-2272 pubmed publisher
  18. Raju K, Doulias P, Evans P, Krizman E, Jackson J, Horyn O, et al. Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation. Sci Signal. 2015;8:ra68 pubmed publisher
    ..GLT1 [also known as EAAT2 (excitatory amino acid transporter 2)], a glutamate transporter in astrocytes, was S-nitrosylated at Cys(373) and Cys(561) in wild-type and ..
  19. Yamamoto Y, Sawa R, Wake I, Morimoto A, Okimura Y. Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells. Nutr Res. 2017;47:13-20 pubmed publisher
    ..Regarding LAT1-related transporters, glucose also reduced the level of sodium-dependent neutral amino acid transporter 2 mRNA, but not that of 4F2 heavy chain...
  20. Gallart Palau X, Serra A, Qian J, Chen C, Kalaria R, Sze S. Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. Neurochem Int. 2015;80:87-98 pubmed publisher
    ..0⋅10(-3)), whereas SNAP25 (1.6; p = 5.5⋅10(-3)), bassoon (1.4; p = 1.3⋅10(-3)), excitatory amino acid transporter 2 (2.6; p = 9.2⋅10(-3)) and Ca(2+)/calmodulin dependent kinase II (1.6; p = 3...
  21. Mitchell M, Strick R, Strissel P, Dittrich R, McPherson N, Lane M, et al. Gene expression and epigenetic aberrations in F1-placentas fathered by obese males. Mol Reprod Dev. 2017;84:316-328 pubmed publisher
    ..paternal diet-induced obesity on deregulated expression of Peg3, Peg9, Peg10, and the nutrient transporter gene Slc38a2, and aberrant DNA methylation of the Peg9 promoter in F1 placental tissue...
  22. Du N, Liu S, Niu M, Duan Y, Zhang S, Yao J, et al. Transmission and characterization of bla NDM-1 in Enterobacter cloacae at a teaching hospital in Yunnan, China. Ann Clin Microbiol Antimicrob. 2017;16:58 pubmed publisher
    ..aadA2, aadA5, aadB, aac(6')-Ib-cr), sulfamethoxazole/trimethoprim (dfrA17, dfrA12, dfrA15) and Streptozotocin (sat2). Six E. cloacae isolates belonged to ST74 and exhibited highly similar PFGE patterns...
  23. Pidoux G, Gerbaud P, Guibourdenche J, Thérond P, Ferreira F, Simasotchi C, et al. Formaldehyde Crosses the Human Placenta and Affects Human Trophoblast Differentiation and Hormonal Functions. PLoS ONE. 2015;10:e0133506 pubmed publisher
    ..Finally, we demonstrate that the adverse effects of formaldehyde on trophoblast differentiation and fusion are reversed by N-acetyl-L-cysteine (Nac), an antioxidant. ..
  24. Cortés Cortés G, Lozano Zarain P, Torres C, Alonso C, Ríos Torres A, Castañeda M, et al. Extended-spectrum β-lactamase-producing Escherichia coli isolated from healthy humans in Mexico, including subclone ST131-B2-O25:H4-H30-Rx. J Glob Antimicrob Resist. 2017;9:130-134 pubmed publisher
    ..coli by PCR and sequencing, as well as gene cassette arrays in class 1 (dfrA17-aadA5) and class 2 (dfrA1-sat2-aadA1) integrons...
  25. Milton I, Banner S, Ince P, Piggott N, Fray A, Thatcher N, et al. Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study. Brain Res Mol Brain Res. 1997;52:17-31 pubmed
    ..in human post-mortem tissue, was produced to the human astrocytic glutamate transporter EAAT2 (excitatory amino acid transporter 2)...
  26. Dai W, Wang Q, Zhao F, Liu J, Liu H. Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry. BMC Genomics. 2018;19:403 pubmed publisher
    ..ACAT1, IDH1, SCP2, ECHDC1), more active fatty acid beta-oxidation (HMGCS1), less amino acid/protein transport (SLC38A2, SLC7A8, RAB5a, VPS18), reduced protein translation (RPS6, RPS12, RPS16, RPS19, RPS20, RPS27), more proteasome- (..
  27. Cisneros I, Ghorpade A. Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014;85:499-507 pubmed publisher
    ..To our knowledge this is the first report implicating astrocyte TAAR1 as a novel receptor for METH during combined injury in the context of HAND. ..
  28. Wu Y, Yin Q, Lin S, Huang X, Xia Q, Chen Z, et al. Increased SLC7A8 expression mediates L-DOPA uptake by renal tubular epithelial cells. Mol Med Rep. 2017;16:887-893 pubmed publisher
    ..by cells of the proximal tubular epithelium of the kidney is controlled by the L‑type amino acid transporter 2 (LAT2)...
  29. Siqueira A, Michael G, Domingos D, Ferraz M, Ribeiro M, Schwarz S, et al. Diversity of class 1 and 2 integrons detected in Escherichia coli isolates from diseased and apparently healthy dogs. Vet Microbiol. 2016;194:79-83 pubmed publisher
    ..Class 2 integrons carried the array dfrA1-sat2-aadA30...
  30. Taitt C, Leski T, Heang V, Ford G, Prouty M, Newell S, et al. Antimicrobial resistance genotypes and phenotypes from multidrug-resistant bacterial wound infection isolates in Cambodia. J Glob Antimicrob Resist. 2015;3:198-204 pubmed publisher
    ..quinolones [qnrS (14%) and qnrB (5%)], sulfonamides [sul1 (29%), sul2 (38%) and sul3 (10%)], streptothricin (sat2) and trimethoprim (6 genes)...
  31. Mostafa M, Siadat S, Shahcheraghi F, Vaziri F, Japoni Nejad A, Vand Yousefi J, et al. Variability in gene cassette patterns of class 1 and 2 integrons associated with multi drug resistance patterns in Staphylococcus aureus clinical isolates in Tehran-Iran. BMC Microbiol. 2015;15:152 pubmed publisher
    ..Gene cassette arrays aadB, aadA2 and dhfrA1-sat2-aadA1 were common in S.aureus isolates...
  32. Lu L, Huang Y, Chen D, Wang M, Zou Y, Wan H, et al. Astragalus polysaccharides decrease muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6 nephrectomised rats. J Ethnopharmacol. 2016;186:125-135 pubmed publisher
    ..In molecular levels, APS restored Akt/mTOR, MAFbx, MuRF1, Atg7, LC3B-II/LC3B-I and SLC38A2 which changed in nephrectomised rats. Data in vitro show the optimal dose of APS is 0...
  33. Lee S, Lee Y, Kim R, Park J, Park M, Ko M, et al. Rapid Engineering of Foot-and-Mouth Disease Vaccine and Challenge Viruses. J Virol. 2017;91: pubmed publisher
    ..strain O1/Manisa/Turkey/69 was replaced with the amplified or synthetic genes from the O, A, Asia1, C, SAT1, SAT2, and SAT3 serotypes. Viruses of the seven serotype were rescued successfully...
  34. Honjo H, Kaira K, Miyazaki T, Yokobori T, Kanai Y, Nagamori S, et al. Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma. J Surg Oncol. 2016;113:381-9 pubmed publisher
    ..Accordingly, these proteins could serve as prognostic biomarkers and therapeutic targets for treating patients with surgically resectable ESCC. J. Surg. Oncol. 2016;113:381-389. © 2016 Wiley Periodicals, Inc. ..
  35. Kao M, Columbus D, Suryawan A, Steinhoff Wagner J, Hernandez Garcia A, Nguyen H, et al. Enteral β-hydroxy-β-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab. 2016;310:E1072-84 pubmed publisher
    ..Phosphorylation of eIF2α and eEF2 and expression of SNAT2, LAT1, MuRF1, atrogin-1, and LC3-II were unchanged...
  36. Wen F, Liu L, Xu Z, Yang J, Ding S. [Dopamine inhibits glutamate-uptake ability of astrocytes via TAAR1-EAAT2 pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:930-935 pubmed
    ..Glu)-uptake ability of astrocytes, and the role of trace amine-associated receptor 1-excitatory amino acid transporter 2 (TAAR1-EAAT2) signaling pathway in Glu uptake by astrocytes...
  37. Bachanek Bankowska K, Mero H, Wadsworth J, Mioulet V, Sallu R, Belsham G, et al. Development and evaluation of tailored specific real-time RT-PCR assays for detection of foot-and-mouth disease virus serotypes circulating in East Africa. J Virol Methods. 2016;237:114-120 pubmed publisher
    ..AFRICA, lineage G-I), serotype O (topotypes EA-2 and EA-4), serotype SAT 1 (topotype I (NWZ)) and serotype SAT2 (topotype IV) were correctly identified with these rRT-PCR assays...
  38. Moen M, Fjær R, Hamdani E, Laerdahl J, Menchini R, Vigeland M, et al. Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport. Brain. 2016;139:3109-3120 pubmed
    ..cells in a K+ dependent manner and regulates activity of the neuronal glutamine transporter SAT2 (Slc38a2), while the F232fs variant impairs K+ fluxes and obliterates SAT2-dependent glutamine transport...
  39. Kagawa S, Nishii R, Higashi T, Yamauchi H, Ogawa E, Okudaira H, et al. Relationship between [14C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [3H]methionine uptake. Nucl Med Biol. 2017;49:8-15 pubmed publisher
    ..sup>11C]MeAIB is therefore expected to be very useful in PET imaging. ..
  40. Keller M, Gatti D, Schueler K, Rabaglia M, Stapleton D, Simecek P, et al. Genetic Drivers of Pancreatic Islet Function. Genetics. 2018;209:335-356 pubmed publisher
    ..as three genes with nominal association with diabetes-related traits in humans (FAM83E, IL6ST, and SAT2)...
  41. Okudaira H, Nakanishi T, Oka S, Kobayashi M, Tamagami H, Schuster D, et al. Kinetic analyses of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2. Nucl Med Biol. 2013;40:670-5 pubmed publisher
    ..were performed in Xenopus laevis oocytes over-expressing either ASCT2 or sodium-coupled neutral amino acid transporter 2 (SNAT2), both of which are highly expressed in prostate cancer cells...
  42. Pacheco J, Smoliga G, O Donnell V, Brito B, Stenfeldt C, Rodriguez L, et al. Persistent Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Cattle; Tissue-Specific Distribution and Local Cytokine Expression. PLoS ONE. 2015;10:e0125698 pubmed publisher
    ..Analysis of 28 distinct anatomic sites from 21 steers infected with FMDV serotype A, O or SAT2, had the highest prevalence of overall viral detection in the dorsal nasopharynx (80...
  43. Xian Y, Wu M, Liu Y, Hao J, Wu Y, Liao X, et al. Increased Sat2 expression is associated with busulfan-induced testicular Sertoli cell injury. Toxicol In Vitro. 2017;43:47-57 pubmed publisher
    ..Here, we showed that spermidine/spermine N1-acetyltransferase 2 (Sat2) was present in testicular Sertoli cells, and its expression was significantly increased by busulfan treatment...
  44. Mavrogonatou E, Papadimitriou K, Urban J, Papadopoulos V, Kletsas D. Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells. J Cell Physiol. 2015;230:3037-48 pubmed publisher
    ..of >100 and >200 genes, respectively, including nine genes encoding transporters (SLC4A11, SLC5A3, ATP1A1, SLC38A2, KCNK17, KCTD20, KCTD11, SLC7A5, and CLCA2)...
  45. Aye I, Jansson T, Powell T. TNF-α stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling. Physiol Rep. 2015;3: pubmed publisher
    ..TNF-α significantly increased the protein expression of System A transporters SNAT1 and SNAT2, but did not affect their mRNA expression...
  46. Chitray M, Grazioli S, Willems T, Tshabalala T, De Vleeschauwer A, Esterhuysen J, et al. Development and validation of a foot-and-mouth disease virus SAT serotype-specific 3ABC assay to differentiate infected from vaccinated animals. J Virol Methods. 2018;255:44-51 pubmed publisher
    ..and IZSLER-NSP), using panels of field and experimental sera, vaccinated and/or infected with FMDV SAT1, SAT2 or SAT3...
  47. Nüsken E, Gellhaus A, Kühnel E, Swoboda I, Wohlfarth M, Vohlen C, et al. Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming. J Cell Biochem. 2016;117:1594-603 pubmed publisher
    ..Gene and protein expression of placental nutrient transporters for fatty acids (h-FABP, CD36), amino acids (SNAT1, SNAT2) and glucose (GLUT-1, Connexin 26) were examined by qRT-PCR, western blot and immunohistochemistry...
  48. Hung C, Lin C, Chang H, Wang C, Lin S, Hsu P, et al. Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity. J Neurosci. 2016;36:2027-43 pubmed publisher
    ..were accompanied by attenuated glutamate uptake and expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in LPS-treated astrocytes...
  49. Abdela N. Sero-prevalence, risk factors and distribution of foot and mouth disease in Ethiopia. Acta Trop. 2017;169:125-132 pubmed publisher
    ..In Ethiopia endemic distributions of five of seven serotypes, namely serotypes O, A, C, SAT1 and SAT2 have been documented...
  50. Leke R, Schousboe A. The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle. Adv Neurobiol. 2016;13:223-257 pubmed
    ..the transporter isoforms SNAT3 and SNAT5 that are related to efflux from the astrocytic compartment, and SNAT1 and SNAT2 that are associated with glutamine uptake into the neuronal compartment...
  51. Niklaus S, Cadetti L, Vom Berg Maurer C, Lehnherr A, Hotz A, Forster I, et al. Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters. Eneuro. 2017;4: pubmed publisher
    ..By using a combination of biophysical and in vivo studies, we elucidate the role of excitatory amino acid transporter 2 (EAAT2) proteins in synaptic glutamate homeostasis at the zebrafish photoreceptor synapse...
  52. Carnicelli D, Arfilli V, Onofrillo C, Alfieri R, Petronini P, Montanaro L, et al. Cap-independent protein synthesis is enhanced by betaine under hypertonic conditions. Biochem Biophys Res Commun. 2017;483:936-940 pubmed publisher
    ..In the presence of betaine, CrPV IRES- and sodium-dependent neutral amino acid transporter-2 (SNAT2) 5'-UTR-driven translation is 2- and 1.5-fold stimulated in MCF7 cells, respectively...
  53. Medras Z, El Sayed N, Zaitone S, Toraih E, Sami M, Moustafa Y. Glutamine up-regulates pancreatic sodium-dependent neutral aminoacid transporter-2 and mitigates islets apoptosis in diabetic rats. Pharmacol Rep. 2018;70:233-242 pubmed publisher
    ..insulin production and upregulation of the expression of sodium-dependent neutral aminoacid transporter-2 (SNAT2). In the present study, diabetes mellitus was induced in rats using streptozotocin (STZ, 50mg/kg, ip)...
  54. Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, et al. Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma. Pathol Oncol Res. 2015;21:1175-81 pubmed publisher
    ..LAT1, 4F2hc and ASCT2 were highly expressed in patients with advanced laryngeal cancer. Our study suggests that the expression of LAT1 plays a crucial role in the metastasis and tumor progression in advanced LSCC. ..
  55. Scott K, Rathogwa N, Capozzo A, Maree F. Evaluation of immune responses of stabilised SAT2 antigens of foot-and-mouth disease in cattle. Vaccine. 2017;35:5426-5433 pubmed publisher
    ..This is especially so for serotypes O and SAT2 which are unstable in mildly acidic pH conditions or at elevated temperatures leading to dissociation of the capsid ..
  56. Mandò C, Tabano S, Pileri P, Colapietro P, Marino M, Avagliano L, et al. SNAT2 expression and regulation in human growth-restricted placentas. Pediatr Res. 2013;74:104-10 pubmed publisher
    ..We hypothesized lower placental expression and localization of sodium-coupled neutral amino acid transporter 2 (SNAT2 (also known as SLC38A2)), altered levels of intron-1 methylation, and altered distribution of ..
  57. Nardi F, Hoffmann T, Stretton C, Cwiklinski E, Taylor P, Hundal H. Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability. J Biol Chem. 2015;290:8173-84 pubmed publisher
    Expression and activity of the System A/SNAT2 (SLC38A2) amino acid transporter is up-regulated by amino acid starvation and hypertonicity by a mechanism dependent on both ATF4-mediated transcription of the SLC38A2 gene and enhanced ..
  58. Krokowski D, Jobava R, Guan B, Farabaugh K, Wu J, Majumder M, et al. Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity. J Biol Chem. 2015;290:17822-37 pubmed publisher
    ..The immediate response to this stress includes the induction of expression of the neutral amino acid transporter SNAT2. Increased SNAT2-mediated uptake of neutral amino acids is an essential adaptive mechanism for restoring cell ..
  59. Nelin L, Nash H, Chicoine L. Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1232-9 pubmed
    ..This suggests that induction of NOS and/or AR is linked to induction of CAT-2 in BPAECs and may represent a mechanism for maintaining L-Arg availability to NOS and/or AR...
  60. Gjymishka A, Palii S, Shan J, Kilberg M. Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. J Biol Chem. 2008;283:27736-47 pubmed publisher
    ..An ATF4 target gene, SNAT2 (system A sodium-dependent neutral amino acid transporter 2), contains a C/EBP-ATF site that binds ATF4 and triggers increased transcription during the AAR...
  61. Iruloh C, D Souza S, Fergusson W, Baker P, Sibley C, Glazier J. Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. Pediatr Res. 2009;65:51-6 pubmed publisher
    ..No significant differences were observed in system A mRNA expression (encoding SNAT1 and SNAT2) or system A activity between the two groups...
  62. Lee M, Martinez Lozada Z, Krizman E, Robinson M. Brain endothelial cells induce astrocytic expression of the glutamate transporter GLT-1 by a Notch-dependent mechanism. J Neurochem. 2017;143:489-506 pubmed publisher
    Neuron-secreted factors induce astrocytic expression of the glutamate transporter, GLT-1 (excitatory amino acid transporter 2)...
  63. Dunlop J, Lou Z, McIlvain H. Properties of excitatory amino acid transport in the human U373 astrocytoma cell line. Brain Res. 1999;839:235-42 pubmed
    ..of both KA and DHK indicates that the predominant astroglial L-glutamate transporter EAAT2 (excitatory amino acid transporter 2) does not contribute to the uptake activity present in these cells...
  64. Sugawara M, Nakanishi T, Fei Y, Huang W, Ganapathy M, Leibach F, et al. Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. J Biol Chem. 2000;275:16473-7 pubmed
    ..This transporter, designated ATA2 for amino acid transporter A2, was cloned from rat skeletal muscle...
  65. Pinilla J, Aledo J, Cwiklinski E, Hyde R, Taylor P, Hundal H. SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?. Front Biosci (Elite Ed). 2011;3:1289-99 pubmed
    We have investigated the effect of chronic competitive inhibition of SNAT2 (System A) amino acid (AA) transport, induced by incubation with a saturating dose of a non-metabolisable System A amino acid analogue (Me-AIB), on growth and ..
  66. Chen C, Wang J, Cai R, Yuan Y, Guo Z, Grewer C, et al. Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification. PLoS ONE. 2016;11:e0158319 pubmed publisher
    Sodium-coupled neutral amino acid transporter 2 (SNAT2) belongs to solute carrier 38 (SLC38) family of transporters, which is ubiquitously expressed in mammalian tissues and mediates transport of small, neutral amino acids, exemplified by ..
  67. Sun P, Zhu X, Shrubsole M, Ness R, Hibler E, Cai Q, et al. Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps. J Nutr Biochem. 2017;47:35-40 pubmed publisher
    Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine...
  68. Usuki F, Fujimura M, Yamashita A. Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters. Sci Rep. 2017;7:12390 pubmed publisher
    ..upregulated the expression of methionine transporters that affect the cellular influx of MeHg, LAT1, LAT3, and SNAT2; and a membrane transporter that affects the efflux of MeHg, ABCC4, in MeHg-susceptible myogenic cells...
  69. Zhang Z, Grewer C. The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. Biophys J. 2007;92:2621-32 pubmed
    The sodium-coupled neutral amino acid transporter SNAT2 mediates cellular uptake of glutamine and other small, neutral amino acids. Here, we report the existence of a leak anion pathway associated with SNAT2...
  70. Jeon Y, Khelifa S, Ratnikov B, Scott D, Feng Y, Parisi F, et al. Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. Cancer Cell. 2015;27:354-69 pubmed publisher
    ..We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the ubiquitin ligase RNF5...
  71. Bröer A, Rahimi F, Broer S. Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. J Biol Chem. 2016;291:13194-205 pubmed publisher
    ..cells and 143B osteosarcoma cells express a set of glutamine transporters including SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT4 (SLC38A4), LAT1 (SLC7A5), and ASCT2 (SLC1A5)...
  72. Schioth H, Roshanbin S, Hägglund M, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013;34:571-85 pubmed publisher
    ..amino acid transporter (VIAAT, SLC32A1), PAT1 (SLC36A1), PAT2 (SLC36A2), PAT4 (SLC36A4), SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT3 (SLC38A3), and SNAT4 (SLC38A4)...
  73. Mortada Y, Khojasteh K, Zarei M, Mansouri A, Jorjani M. How Nitric Oxide Increases in Diabetic Morphine Tolerated Male Rats. Iran J Pharm Res. 2017;16:630-639 pubmed
    ..It seems that the nitric oxide elevation in diabetic morphine tolerated state is mostly due to the increase of iNOS in male rats...
  74. Araújo S, A T Silva I, Tacão M, Patinha C, Alves A, Henriques I. Characterization of antibiotic resistant and pathogenic Escherichia coli in irrigation water and vegetables in household farms. Int J Food Microbiol. 2017;257:192-200 pubmed publisher
    ..intI2 was detected in water (dfrA1-sat2-aadA1). Plasmids were detected in 14 isolates (IncFIC, IncFIB, IncFrep, IncI1 in both samples; IncY in vegetables)...
  75. Diaz P, Dimasuay K, Koele Schmidt L, Jang B, Barbour L, Jansson T, et al. Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. Placenta. 2017;57:52-59 pubmed publisher
    ..isolated and expression of glucose (glucose transporter 1; GLUT1), amino acid (sodium-coupled neutral amino acid transporter 2; SNAT2 and L-type amino acid transporter 1; LAT1) and fatty acid (fatty acid translocase; FAT/CD36, fatty ..
  76. Krokowski D, Guan B, Wu J, Zheng Y, Pattabiraman P, Jobava R, et al. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017;21:2895-2910 pubmed publisher
    ..This adaptation includes induction of SNAT2, an endoplasmic reticulum (ER)-Golgi-processed protein, which helps to reverse the stress-induced loss of cell ..
  77. Rosario F, Dimasuay K, Kanai Y, Powell T, Jansson T. Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. Clin Sci (Lond). 2016;130:499-512 pubmed publisher
    ..increased the expression of Nedd4-2, promoted ubiquitination and decreased the plasma membrane expression of SNAT2 (an isoform of the System A amino acid transporter) and LAT1 (a System L amino acid transporter isoform), ..
  78. Choi D, Kim D, Kanai Y, Wempe M, Endou H, Kim J. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017;21:599-607 pubmed publisher
    Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased growth and proliferation...
  79. Freeman T, Thiele G, Tuma D, Machu T, Mailliard M. ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. Arch Biochem Biophys. 2002;400:215-22 pubmed
    System A, the Na(+)-dependent amino acid transport activity, is encoded by the ATA2 gene and up-regulated following partial hepatectomy (PH), and its competitive inhibition interferes with liver regeneration...
  80. Zhang Z, Albers T, Fiumera H, Gameiro A, Grewer C. A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2). J Biol Chem. 2009;284:25314-23 pubmed publisher
    ..This homology model was tested experimentally in the SLC38 member SNAT2 by analyzing the effect of a mutation to Thr-384, which is predicted to be part of this Na(+) binding site...
  81. Takahashi Y, Nishimura T, Maruyama T, Tomi M, Nakashima E. Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat. Amino Acids. 2017;49:795-803 pubmed publisher
    System A consists of three subtypes, sodium-coupled neutral amino acid transporter 1 (SNAT1), SNAT2, and SNAT4, which are all expressed in the placenta...
  82. Esaki N, Ohkawa Y, Hashimoto N, Tsuda Y, Ohmi Y, Bhuiyan R, et al. ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer. Cancer Sci. 2018;109:141-153 pubmed publisher
    ..Consequently, we identified ASC amino acid transporter 2 (ASCT2), a major glutamine transporter, which coordinately works with GD2...
  83. Novak D, Quiggle F, Haafiz A. Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells. Biochimie. 2006;88:39-44 pubmed
    ..was associated with an up-regulation of SysA activity, largely mediated through an enhancement of SNAT2 (Slc38a2) expression at both the protein and mRNA level...
  84. Jones H, Ashworth C, Page K, McArdle H. Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). Am J Physiol Endocrinol Metab. 2006;291:E596-603 pubmed
    ..This was associated with a relocalization of the SNAT2 transporter at lower cortisol levels and significant upregulation of mRNA and protein expression levels at ..
  85. Agergaard J, Bülow J, Jensen J, Reitelseder S, Bornø A, Drummond M, et al. Effect of light-load resistance exercise on postprandial amino acid transporter expression in elderly men. Physiol Rep. 2017;5: pubmed publisher
    ..LAT1 and PAT1 protein expression increased in response to LL-RE in the PULSE group, and SNAT2 and PAT1 protein expression increased in the BOLUS group when plasma BCAA concentration was low...
  86. Shimamoto K, Lebrun B, Yasuda Kamatani Y, Sakaitani M, Shigeri Y, Yumoto N, et al. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol. 1998;53:195-201 pubmed
  87. Bevilacqua E, Bussolati O, Dall Asta V, Gaccioli F, Sala R, Gazzola G, et al. SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. FEBS Lett. 2005;579:3376-80 pubmed
    Under hypertonic conditions the induction of SLC38A2/SNAT2 leads to the stimulation of transport system A and to the increase in the cell content of amino acids...
  88. Basu A, Das P, Chaudhuri S, Bevilacqua E, Andrews J, Barik S, et al. Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites. Mol Cell Biol. 2011;31:4482-99 pubmed publisher
    ..the mechanism of 80S complex formation on IRES elements from the cellular sodium-coupled neutral amino acid transporter 2 (SNAT2) versus the hepatitis C virus mRNA...
  89. Boeuf P, Aitken E, Chandrasiri U, Chua C, McInerney B, McQuade L, et al. Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport. PLoS Pathog. 2013;9:e1003153 pubmed publisher
    ..However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM. ..
  90. Matott M, Kline D, Hasser E. Glial EAAT2 regulation of extracellular nTS glutamate critically controls neuronal activity and cardiorespiratory reflexes. J Physiol. 2017;595:6045-6063 pubmed publisher
    Excitatory amino acid transporter 2 (EAAT2) is present on astrocytes in the nucleus tractus solitarii (nTS), an important nucleus in cardiorespiratory control...
  91. Briffa J, Hosseini S, Tran M, Moritz K, Cuffe J, Wlodek M. Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters. Placenta. 2017;59:30-38 pubmed publisher
    ..Maternal growth restriction reduced placental Slc2a1, Igf2, Slc38a2 and Nr3c1 gene expression...
  92. Palii S, Chen H, Kilberg M. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem. 2004;279:3463-71 pubmed
    System A amino acid transporter (SNAT2) gene expression is up-regulated at the transcriptional level in response to amino acid deprivation...