SLC36A1

Summary

Gene Symbol: SLC36A1
Description: solute carrier family 36 (proton/amino acid symporter), member 1
Alias: Dct1, LYAAT1, PAT1, TRAMD3, hPAT1, lysosomal amino acid transporter 1, proton-coupled amino acid transporter 1, proton/amino acid transporter 1, solute carrier family 36 member 1
Species: human

Top Publications

  1. ncbi Renal and intestinal transport defects in Slc26a6-null mice
    Zhaohui Wang
    Department of Internal Medicine, Division of Nephrology and Hypertension, Univ of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati OH 45267 0585, USA
    Am J Physiol Cell Physiol 288:C957-65. 2005
  2. ncbi Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)
    S Frølund
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 159:1339-53. 2010
  3. ncbi An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    Micah J Drummond
    University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, Sealy Center on Aging, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 298:E1011-8. 2010
  4. ncbi Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:22966-73. 2002
  5. ncbi Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1
    Madlen Dorn
    Institute of Biochemistry Biotechnology, Faculty of Science I, Biozentrum, Martin Luther University Halle Wittenberg, Halle, Germany
    J Biol Chem 284:22123-32. 2009
  6. ncbi Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
    S Heublein
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Oncogene 29:4068-79. 2010
  7. ncbi Identification and characterization of a lysosomal transporter for small neutral amino acids
    C Sagne
    Institut National de la Santé et de la Recherche Médicale U 513, CHU Henri Mondor, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Proc Natl Acad Sci U S A 98:7206-11. 2001
  8. ncbi Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2
    Zhong Chen
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    J Physiol 546:349-61. 2003
  9. ncbi The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons
    Christopher C Wreden
    Department of Neurology and Physiology, University of California San Francisco School of Medicine, San Francisco, California 94143 0435, USA
    J Neurosci 23:1265-75. 2003
  10. ncbi H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat
    Catriona M H Anderson
    Faculty of Medical Sciences, nUniversity of Newcastle Upon Tyne, Newcasttle Upon Tyne, UK
    Gastroenterology 127:1410-22. 2004

Research Grants

  1. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep Dudeja; Fiscal Year: 2009
  2. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2010
  3. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2010
  4. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
  5. Genetic Models for Disorders of Acid-Base Transport
    Gary E Shull; Fiscal Year: 2010
  6. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
  7. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
  8. LIGHT RESPONSIVE GENES
    Nam Hai Chua; Fiscal Year: 2006
  9. MRNA DECAPPING IN YEAST
    Roy Parker; Fiscal Year: 2007
  10. Mouse Models for Ion Homeostasis Defects in Heart
    Gary E Shull; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications110 found, 100 shown here

  1. ncbi Renal and intestinal transport defects in Slc26a6-null mice
    Zhaohui Wang
    Department of Internal Medicine, Division of Nephrology and Hypertension, Univ of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati OH 45267 0585, USA
    Am J Physiol Cell Physiol 288:C957-65. 2005
    SLC26A6 (PAT1, CFEX) is an anion exchanger that is expressed on the apical membrane of the kidney proximal tubule and the small intestine...
  2. ncbi Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)
    S Frølund
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 159:1339-53. 2010
    ..Oral administration of ALA has been used in patients with prostate and bladder cancer. The present aim was to investigate the mechanism of intestinal absorption of ALA and its transport via the amino acid transporter SLC36A1.
  3. ncbi An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    Micah J Drummond
    University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, Sealy Center on Aging, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 298:E1011-8. 2010
    ..transporter (LAT1), CD98, sodium-coupled neutral AA transporter (SNAT2), and proton-coupled amino acid transporter (PAT1) mRNA expression at 1 h (P < 0...
  4. ncbi Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:22966-73. 2002
    ..Phenotypically, the PAT1 transporter possesses the same functional characteristics as the previously described proton-dependent amino acid ..
  5. ncbi Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1
    Madlen Dorn
    Institute of Biochemistry Biotechnology, Faculty of Science I, Biozentrum, Martin Luther University Halle Wittenberg, Halle, Germany
    J Biol Chem 284:22123-32. 2009
    The proton-coupled amino acid transporter 1 (PAT1, SLC36A1) mediates the uptake of small neutral amino acids at the apical membrane of intestinal epithelial cells after protein digestion...
  6. ncbi Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
    S Heublein
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Oncogene 29:4068-79. 2010
    ..In this study, we show the two human PATs that are widely expressed in normal tissues and cancer cell lines, namely PAT1 and PAT4, behave similarly to fly PATs when expressed in Drosophila...
  7. ncbi Identification and characterization of a lysosomal transporter for small neutral amino acids
    C Sagne
    Institut National de la Santé et de la Recherche Médicale U 513, CHU Henri Mondor, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Proc Natl Acad Sci U S A 98:7206-11. 2001
    ..Homology searching in eukaryotic genomes suggests that LYAAT-1 defines a subgroup of lysosomal transporters in the amino acid/auxin permease family...
  8. ncbi Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2
    Zhong Chen
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    J Physiol 546:349-61. 2003
    The human orthologue of the H(+)-coupled amino acid transporter (hPAT1) was cloned from the human intestinal cell line Caco-2 and its functional characteristics evaluated in a mammalian cell heterologous expression system...
  9. ncbi The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons
    Christopher C Wreden
    Department of Neurology and Physiology, University of California San Francisco School of Medicine, San Francisco, California 94143 0435, USA
    J Neurosci 23:1265-75. 2003
    Recent work has identified a lysosomal protein that transports neutral amino acids (LYAAT1)...
  10. ncbi H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat
    Catriona M H Anderson
    Faculty of Medical Sciences, nUniversity of Newcastle Upon Tyne, Newcasttle Upon Tyne, UK
    Gastroenterology 127:1410-22. 2004
    ..the recently isolated complementary DNA hPAT1 (human proton-coupled amino acid transporter 1), or solute carrier SLC36A1, represents the imino acid carrier; the Na(+) -dependent imino acid transport function measured at the brush-..
  11. ncbi Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2)
    David J Kennedy
    Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Br J Pharmacol 144:28-41. 2005
    ..in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e...
  12. ncbi The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, Hochfeldweg 2, 85350, Freising Weihenstephan, Germany
    Pflugers Arch 447:776-9. 2004
    ..in both intracellular and plasma membranes, was identified independently as a lysosomal amino acid transporter (LYAAT1) responsible for the export of lysosomal proteolysis products into the cytosol and as a proton/amino acid ..
  13. ncbi The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics
    S Frølund
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    Br J Pharmacol 161:589-600. 2010
    BACKGROUND AND PURPOSE The intestinal proton-coupled amino acid transporter, SLC36A1, transports zwitterionic α-amino acids and drugs such as vigabatrin, gaboxadol and δ-aminolevulinic acid...
  14. ncbi Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides
    Louisa Benboudjema
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Virol 77:9192-203. 2003
    ..host targets for the Us11 protein, we searched for cellular proteins that interact with Us11 and have identified PAT1 as a Us11-binding protein according to multiple, independent experimental criteria...
  15. ncbi Dietary fructose, salt absorption and hypertension in metabolic syndrome: towards a new paradigm
    M Soleimani
    Center on Genetics of Transport and Epithelial Biology, Department of Medicine, University of Cincinnati, OH 45267 0585, USA
    Acta Physiol (Oxf) 201:55-62. 2011
    ..intestine is predominantly mediated via the chloride/base exchangers DRA (Down Regulated in Adenoma) (SLC26A3) and PAT1 (Putative Anion Transporter 1) (SLC26A6), and the Na(+) /H(+) exchanger NHE3 (Sodium Hydrogen Exchanger3) (SLC9A3)...
  16. ncbi Regulation of meiosis in fission yeast
    M Yamamoto
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Cell Struct Funct 21:431-6. 1996
    ..To initiate meiosis in S. pombe, a protein kinase encoded by pat1 (also called ran1) should be inactivated...
  17. ncbi Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2
    Zhong Chen
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 304:747-54. 2003
    ..The cDNA codes for a protein of 481 amino acids with 72% identity (over 449 amino acids) with rat PAT1. Tissue expression studies demonstrate that mRNA abundance is generally low with highest levels being detected in ..
  18. ncbi Colocalization of the apical Cl-/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells
    Snezana Petrovic
    Department of Medicine, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1207-16. 2002
    The apical Cl-/HCO exchanger called the putative anion transporter (PAT1; SLC26A6) is expressed on apical membranes of villus cells in the duodenum, but its location in the stomach remains unknown...
  19. ncbi Monocarboxylate transporter 1 mediates DL-2-Hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers
    Raquel Martín-Venegas
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, 08028 Barcelona, Spain
    J Nutr 137:49-54. 2007
    ..with L-Ala, beta-Ala, D-Pro, betaine, or glycyl-sarcosine excluded the participation of systems proton amino acid transporter 1 and peptide transporter 1...
  20. ncbi Genetic evidence for the importance of protein acetylation and protein deacetylation in the halophilic archaeon Haloferax volcanii
    Neta Altman-Price
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Israel
    J Bacteriol 191:1610-7. 2009
    ..volcanii led to the identification of three putative protein acetyltransferases belonging to the Gcn5 family, Pat1, Pat2, and Elp3, and two deacetylases, Sir2 and HdaI...
  21. ncbi Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine
    Catriona M H Anderson
    Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    J Pharmacol Exp Ther 332:220-8. 2010
    ..between ALA and GABA led us to test the hypothesis that the H(+)-coupled amino acid transporter PAT1 (SLC36A1) will contribute to luminal ALA uptake...
  22. ncbi Expression of the Rickettsia prowazekii pld or tlyC gene in Salmonella enterica serovar Typhimurium mediates phagosomal escape
    Ted Whitworth
    Department of Pathology, University of Texas Medical Branch at Galveston, 77555 0609, USA
    Infect Immun 73:6668-73. 2005
    ..species have allowed for the identification of four genes with potential membranolytic activities (tlyA, tlyC, pat1, and pld)...
  23. ncbi Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation
    A Grallert
    Department of Genetics, University of Debrecen, Hungary
    Yeast 15:669-86. 1999
    ..The mutations in sep8, sep11 and sep16 suppressed the pat1-114-driven meiosis...
  24. ncbi Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct
    Hiroshi Ishiguro
    Laboratory of Human Nutrition, Nagoya Univ Graduate School of Medicine, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G447-55. 2007
    The role of Slc26a6 (PAT1) on apical Cl-/HCO3- exchange and bicarbonate secretion in pancreatic duct cells was investigated using Slc26a6 null and wild-type (WT) mice...
  25. ncbi Transport of L-proline, L-proline-containing peptides and related drugs at mammalian epithelial cell membranes
    M Brandsch
    Membrane Transport Group, Biozentrum, Martin Luther University Halle Wittenberg, Halle, Germany
    Amino Acids 31:119-36. 2006
    ..The amino acid transporter PAT1, expressed in intestine, kidney, brain and other organs, mediates the uptake of proline and derivatives in a pH ..
  26. ncbi Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis
    Zhe Peng
    Program in Molecular and Cellular Biology, State University of New York Health Science Center at Brooklyn, Department of Microbiology and Immunology, Morse Institute for Molecular Biology and Genetics, Brooklyn, NY 11203, USA
    Curr Genet 43:178-85. 2003
    Ran1/Pat1 kinase and cAMP-dependent protein kinase (PKA) regulate sexual differentiation in Schizosaccharomyces pombe. A reduction in the activity of both enzymes is a prerequisite for meiosis...
  27. ncbi Negative regulatory regions of the PAT1 promoter of Hz-1 virus contain GATA elements which associate with cellular factors and regulate promoter activity
    H H Chen
    Institute of Biotechnology and Department of Biology, National Cheng Kung University, Tainan 701, Taiwan
    J Gen Virol 82:313-20. 2001
    The persistence-associated transcript 1 (PAT1) is actively expressed during persistent infection with Hz-1 virus, while transcription of the rest of the viral genes is shut down...
  28. ncbi Co-operative versus independent transport of different cargoes by Kinesin-1
    Jennetta W Hammond
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Traffic 9:725-41. 2008
    ..chain (KLC) subunit, namely the c-Jun NH(2)-terminal kinase-interacting proteins (JIPs) 1 and 3, Kidins220/ARMS and PAT1. Overexpression of individual cargo proteins in differentiated CAD cells resulted in mislocalization of the ..
  29. ncbi Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6
    Seema Saksena
    Department of Medicine, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    J Cell Biochem 105:454-66. 2008
    SLC26A6 (putative anion transporter 1, PAT1) has been shown to play an important role in mediating the luminal Cl(-)/OH(-)(HCO(3)(-)) exchange process in the intestine...
  30. ncbi Characterization of functional regions in the Schizosaccharomyces pombe mei3 developmental activator
    W Wang
    Department of Microbiology and Immunology, Morse Institute for Molecular Biology and Genetics, Health Science Center, State University of New York, Brooklyn, New York 11203, USA
    Genetics 150:1007-18. 1998
    ..Ectopic expression of mei3(+) in haploid cells causes meiotic catastrophe. Mei3 is an inhibitor of Ran1/Pat1 kinase and contains a nine-amino-acid motif, Mei3-RKDIII, that resembles two regions in the Ste11 substrate for ..
  31. ncbi PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle
    R Lin
    Verna and Marrs McLean Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Cells 1:923-42. 1996
    ..Histone acetylation has been shown to play a role in transcription regulation, histone deposition and histone displacement during spermatogenesis, although no known histone acetyltransferase is essential...
  32. ncbi Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis
    Peter R Boag
    Joslin Diabetes Center, Harvard Stem Cell Institute, and 2Department of Pathology, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 182:543-57. 2008
    ..The P body protein Dhh1 inhibits translation and promotes decapping-mediated mRNA decay together with Pat1 in yeast, and has been implicated in mRNA storage in metazoan oocytes...
  33. ncbi Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2
    Martin Foltz
    Molecular Nutrition Unit, Center of Life and Food Sciences, Technical University of Munich, Germany
    Eur J Biochem 271:3340-7. 2004
    ..The PAT2 cDNA has been cloned from various human, mouse and rat tissues and belongs to a group of four genes (pat1 to pat4) with PAT3 and PAT4 still resembling orphan transporters...
  34. ncbi PAT1, a new member of the GRAS family, is involved in phytochrome A signal transduction
    C Bolle
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, New York 10021 6399, USA
    Genes Dev 14:1269-78. 2000
    ..The PAT1 gene encodes a cytoplasmic protein of 490 amino acids with sequence homologies to the plant-specific GRAS ..
  35. ncbi Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine
    Zhaohui Wang
    Department of Medicine, University of Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 282:G573-9. 2002
    ..include downregulated in adenoma (DRA or SLC26A3), pendrin (PDS or SLC26A4), and the putative anion transporter (PAT1 or SLC26A6) has recently been identified...
  36. ncbi Molecular cloning of an intracellular P-type ATPase from Dictyostelium that is up-regulated in calcium-adapted cells
    J Moniakis
    Department of Biology, York University, North York, Ontario, Canada
    J Biol Chem 270:28276-81. 1995
    ..The deduced protein product of this gene (PAT1) has a calculated molecular mass of 120,718 daltons...
  37. ncbi The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe
    M Sipiczki
    Department of Genetics, L K University, Debrecen, Hungary
    Mol Gen Genet 213:529-34. 1988
    ..I found that the ste1, ste3 and ste8 genes act very early in the sexual development, presumably before the pat1-controlled conjugation-specific event...
  38. ncbi Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis
    A Matsuyama
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Genetics 155:539-49. 2000
    ..The temperature-sensitive pat1-114 mutant underwent ectopic conjugation at the semirestrictive temperature when its genetic background was ste7(+),..
  39. ncbi A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe
    Akio Nakashima
    Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, 422 8539, Shizuoka, Japan
    Curr Genet 49:403-13. 2006
    ..b>Pat1 protein kinase negatively controls meiosis, and a temperature-sensitive mutant of pat1, pat1-114, initiates meiosis ..
  40. ncbi SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney
    Minna Kujala
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Nephron Exp Nephrol 101:e50-8. 2005
    The anion transporters SLC26A6 (PAT1) and SLC26A7, transporting at least chloride, oxalate, sulfate and bicarbonate, show a distinct expression and function in different mammalian species...
  41. ncbi Isolation of a mammalian homologue of a fission yeast differentiation regulator
    H Yamamoto
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell Biol 19:3829-41. 1999
    ..By using the phenotypic suppression of the S. pombe temperature-sensitive pat1 mutant that commits lethal haploid meiosis at the restrictive temperature, we have cloned ROD1, a functional ..
  42. ncbi CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3- secretion
    A K Singh
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Acta Physiol (Oxf) 193:357-65. 2008
    We investigated the role of the recently discovered, villous-expressed anion exchanger Slc26a6 (PAT1) and the predominantly crypt-expressed cystic fibrosis transmembrane regulator (CFTR) in basal and acid-stimulated murine duodenal HCO(3)(..
  43. ncbi Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways
    Stephane Hausmann
    Department of Microbiology and Molecular Medicine, University of Geneva, CH1211 Geneva, Switzerland
    J Biol Chem 283:31706-18. 2008
    ..analysis also highlighted synthetic interactions of Tgs1 with proteins implicated in RNA end processing and decay (Pat1, Lsm1, and Trf4) and regulation of polymerase II transcription (Rpn4, Spt3, Srb2, Soh1, Swr1, and Htz1)...
  44. ncbi Isolation, purification, and characterization of phenylpyruvate transaminating enzymes of Erwinia carotovora
    A M Paloyan
    SPC Armbiotechnology, National Academy of Sciences of Republic of Armenia, Yerevan, Republic of Armenia
    Biochemistry (Mosc) 77:98-104. 2012
    ..Two aromatic aminotransferases (PAT1 and PAT2) and an aspartic aminotransferase (PAT3) were found...
  45. ncbi Chemical inactivation of Pat1: A novel approach to synchronize meiosis
    Livia Perez-Hidalgo
    Instituto de Biología Molecular y Celular del Cáncer and Instituto de Biología Funcional y Genómica CSIC Universidad de Salamanca Instituto de Investigación Biomédica de Salamanca Salamanca, Spain
    Cell Cycle 11:1875. 2012
    ..Comment on: Guerra-Moreno A, et al. Cell Cycle 2012; 11:1621-5 and Cipak L, et al. Cell Cycle 2012; 11:1626-33...
  46. ncbi An integrated field-effect microdevice for monitoring membrane transport in Xenopus laevis oocytes via lateral proton diffusion
    Daniel Felix Schaffhauser
    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    PLoS ONE 7:e39238. 2012
    ..Furthermore, the transport activity of the proton/amino acid cotransporter PAT1 assayed using conventional whole cell electrophysiology correlated well with changes in surface pH, confirming the ..
  47. ncbi Phylogenetic and population genetic analyses of Phaeosphaeria nodorum and its close relatives indicate cryptic species and an origin in the Fertile Crescent
    Megan C McDonald
    Plant Pathology Group, Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    Fungal Genet Biol 49:882-95. 2012
    ..Two species, P. nodorum and P. avenaria f. sp. tritici 1 (Pat1), comprised ~85% of the sampled isolates, making them the dominant wheat-infecting pathogens within the species ..
  48. ncbi Carrier-mediated γ-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers
    Carsten Uhd Nielsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken, Copenhagen, Denmark
    Eur J Pharm Biopharm 81:458-62. 2012
    ..The proton-coupled amino acid transporter, hPAT1, mediates the influx of GABA and GABA mimetic drug substances such as vigabatrin and gaboxadol and the anticancer ..
  49. ncbi Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides
    Sidsel Frølund
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Mol Pharm 9:2761-9. 2012
    ..The in vitro methods included two-electrode voltage clamp measurements on hPAT1 expressing Xenopus laevis oocytes, which were used to investigate the PAT1-mediated transport of 17 different ..
  50. ncbi Hijacking solute carriers for proton-coupled drug transport
    Catriona M H Anderson
    Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    Physiology (Bethesda) 25:364-77. 2010
    ..These transporters include PepT1 and PepT2 (SLC15A1/2), PCFT (SLC46A1), PAT1 (SLC36A1), OAT10 (SLC22A13), OATP2B1 (SLCO2B1), MCT1 (SLC16A1), and MATE1 and MATE2-K (SLC47A1/2).
  51. ncbi Pat1: a topoisomerase II-associated protein required for faithful chromosome transmission in Saccharomyces cerevisiae
    X Wang
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nucleic Acids Res 24:4791-7. 1996
    ..cerevisiae, we have used a two-hybrid cloning approach. We report the isolation of the PAT1 gene (for protein associated with topoisomerase II), which encodes a novel 90 kDa proline- and glutamine-rich ..
  52. ncbi Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms
    Tracy Nissan
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Cell 39:773-83. 2010
    ..In yeast cells, Pat1, Scd6, Edc3, and Dhh1 all function to promote decapping by an unknown mechanism(s)...
  53. ncbi Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility
    Philippe Loiseau
    The Zoology Department, University of Cambridge, Cambridge, UK
    Development 137:2763-72. 2010
    ..Using a combination of genetic, biochemical and motor-tracking studies, we show that PAT1, an APP-binding protein, interacts with Kinesin-1, functions in the transport of oskar mRNA and Dynein and is ..
  54. ncbi Rapamycin specifically interferes with the developmental response of fission yeast to starvation
    R Weisman
    Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Israel
    J Bacteriol 179:6325-34. 1997
    ..Nor did rapamycin inhibit the unscheduled meiosis observed in pat1-114 mutants...
  55. ncbi Involvement of the Ca2+-ATPase PAT1 and the contractile vacuole in calcium regulation in Dictyostelium discoideum
    J Moniakis
    Department of Biology, York University, Toronto, Ontario, Canada, M3J 1P3
    J Cell Sci 112:405-14. 1999
    In Dictyostelium discoideum, the Ca2+-ATPase, PAT1, is localized to membranes of the contractile vacuole and its expression is upregulated substantially when the cells are grown in Ca2+-rich medium...
  56. ncbi A Sm-like protein complex that participates in mRNA degradation
    E Bouveret
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 19:1661-71. 2000
    ..Deletions of LSM1, 6, 7 and PAT1 genes increased the half-life of reporter mRNAs...
  57. ncbi Deletion of the PAT1 gene affects translation initiation and suppresses a PAB1 gene deletion in yeast
    F Wyers
    Centre de Genetique Moleculaire, C N R S, 91198 Gif sur Yvette, France
    Mol Cell Biol 20:3538-49. 2000
    ..We found that deletion of the PAT1 (YCR077c) gene suppresses a PAB1 gene deletion and that Pat1p is required for the normal initiation of translation...
  58. ncbi Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan
    M Larsen
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken, Copenhagen, Denmark
    Br J Pharmacol 157:1380-9. 2009
    ..The clinical use of gaboxadol has revealed that adverse effects seem related to peak serum concentrations. The aim of this study was to investigate the mechanism of intestinal absorption of gaboxadol in vitro and in vivo...
  59. ncbi The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p
    C Bonnerot
    Centre de Recherche de Biochimie Macromoleculaire du CNRS, 34293 Montpellier, France
    Mol Cell Biol 20:5939-46. 2000
    ..Cloning of the wild-type gene for that suppressor reveals that it is identical to PAT1 (YCR077c), a gene whose product was reported to interact with Top2p...
  60. ncbi 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p
    Masamitsu Sato
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Hongo, Japan
    Curr Biol 12:141-5. 2002
    The switch from mitosis to meiosis is controlled by the Pat1(Ran1) kinase-Mei2p system in Schizosaccharomyces pombe...
  61. ncbi Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae
    Vidya Balagopal
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, Arizona 85721 0206, USA
    Genetics 181:93-103. 2009
    ..In the budding yeast Saccharomyces cerevisae, decapping is promoted by the Dhh1 and Pat1 proteins, which appear to both inhibit translation initiation and promote decapping...
  62. ncbi Characteristics of transport of selenoamino acids by epithelial amino acid transporters
    A Nickel
    Molecular Nutrition Unit, Nutrition and Food Research Center, Technische Universitat Munchen, Am Forum 5, D 85350 Freising, Germany
    Chem Biol Interact 177:234-41. 2009
    ..studies employed the Xenopus laevis oocyte system expressing the amino acid transporters SIT1, b(0,+)rBAT, B(0) or PAT1 and intestinal Caco-2 and renal OK cell lines that possess a multitude of amino acid transporters...
  63. ncbi Missense mutation in exon 2 of SLC36A1 responsible for champagne dilution in horses
    Deborah Cook
    Department of Veterinary Science, MH Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS Genet 4:e1000195. 2008
    ..genes were identified within the region, namely SPARC [Secreted protein, acidic, cysteine-rich (osteonectin)], SLC36A1 (Solute Carrier 36 family A1), SLC36A2 (Solute Carrier 36 family A2), and SLC36A3 (Solute Carrier 36 family A3)...
  64. ncbi SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes
    Samyuktha Muralidharan Pillai
    School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom
    J Biol Chem 286:2455-60. 2011
    The SLC36 family of transporters consists of four genes, two of which, SLC36A1 and SLC36A2, have been demonstrated to code for human proton-coupled amino acid transporters or hPATs...
  65. ncbi Pat1 proteins: a life in translation, translation repression and mRNA decay
    Aline Marnef
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochem Soc Trans 38:1602-7. 2010
    b>Pat1 proteins are conserved across eukaryotes. Vertebrates have evolved two Pat1 proteins paralogues, whereas invertebrates and yeast only possess one such protein...
  66. ncbi Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase
    P Li
    Department of Microbiology and Immunology, Morse Institute for Molecular Biology and Genetics, State University of New York Health Science Center at Brooklyn 11023, USA
    Cell 87:869-80. 1996
    ran1+ (pat1+) kinase inhibits exit from the mitotic cell cycle and entry into meiosis. Inactivation of ran1+ by mei3+ is sufficient to precipitate the entire meiotic developmental program...
  67. ncbi Molecular cloning of the meiosis-induced rec10 gene of Schizosaccharomyces pombe
    Y Lin
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Curr Genet 27:440-6. 1995
    ..During meiosis, thermally induced in a temperature-sensitive pat1-114 mutant, the transcript of rec10 was induced to a maximal level at 2-3 h but was present at much lower levels ..
  68. ncbi A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast
    T Obara-Ishihara
    Okayama Cell Switching Project, ERATO, JRDC, Kyoto, Japan
    EMBO J 13:1863-72. 1994
    ..The Pat1 kinase plays a pivotal role in switching between vegetative growth and sexual development, and its inactivation in ..
  69. ncbi Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe
    Y Lin
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genetics 136:769-79. 1994
    ..After pat1-114 temperature-induced meiosis, the transcripts of rec6 and rec12 were induced to maximal levels at 2-3 hr, at ..
  70. ncbi An intron-containing meiosis-induced recombination gene, rec15, of Schizosaccharomyces pombe
    Y Lin
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Microbiol 17:439-48. 1995
    ..During thermally induced meiosis in a pat1-114 (Ts) mutant, the rec15 transcripts were induced to maximal levels at 2-3h but were present at much lower levels ..
  71. ncbi Two novel genes involved in the sexual development of Schizosaccharomyces pombe
    M Molnar
    Department of Genetics, and Institute of Biology, University of Debrecen, Hungary
    Curr Genet 28:447-53. 1995
    ..ste15 is conjugation-specific and acts upstream of pat1 and ras1...
  72. ncbi Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae
    Kylie D Swisher
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e26547. 2011
    ..Upf2 or Upf3 leads to the accumulation of not only Upf1 and Dcp2 in P-bodies, but also of the decapping-activators Pat1, Dhh1, and Lsm1...
  73. ncbi Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1)
    Iris Thondorf
    Institute of Biochemistry and Biotechnology, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, D 06099 Halle, Germany
    Bioorg Med Chem 19:6409-18. 2011
    The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration...
  74. ncbi The role of salt in the pathogenesis of fructose-induced hypertension
    Manoocher Soleimani
    The Center on Genetics of Transport and Epithelial Biology, University of Cincinnati, 231 Albert Sabin Way, MSB 6312, Cincinnati, OH 45267 0585, USA
    Int J Nephrol 2011:392708. 2011
    ..point to a novel interaction between the fructose-absorbing transporter, Glut5, and the salt transporters, NHE3 and PAT1, in the intestine and kidney proximal tubule...
  75. ncbi Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise
    Micah J Drummond
    University of Texas Medical Branch, Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, Sealy Center on Aging, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol 111:135-42. 2011
    ..CD98/SLC3A2, sodium-coupled neutral amino acid transporter 2/SLC38A2, proton-assisted amino acid transporter 1/SLC36A1, and cationic amino acid transporter 1/SLC7A1 mRNA expression in both young and older adults (P < 0.05)...
  76. ncbi The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport
    David T Thwaites
    Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Br J Pharmacol 164:1802-16. 2011
    ..SLC36 consists of four members. SLC36A1 and SLC36A2 both function as H(+) -coupled amino acid symporters...
  77. ncbi Lsm1 promotes genomic stability by controlling histone mRNA decay
    Ana B Herrero
    Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    EMBO J 30:2008-18. 2011
    Lsm1 forms part of a cytoplasmic protein complex, Lsm1-7-Pat1, involved in the degradation of mRNAs. Here, we show that Lsm1 has an important role in promoting genomic stability in Saccharomyces cerevisiae...
  78. ncbi P-body components, Dhh1 and Pat1, are involved in tRNA nuclear-cytoplasmic dynamics
    Rebecca L Hurto
    Department of Molecular Genetics, The Center For RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA
    RNA 17:912-24. 2011
    ..Dhh1 and Pat1 function in parallel to promote translation repression and P-body formation in response to starvation...
  79. ncbi Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast
    Takaharu G Yamamoto
    Cell Biology Group and CREST Research Project, Kansai Advanced Research Center, National Institute of Information and Communication Technology, 588 2 Iwaoka cho, Iwaoka, Nishi ku, Kobe 651 2492, Japan
    J Cell Sci 117:3875-86. 2004
    ..Mei2 (a key positive regulator of meiosis), but did not require Mei3; Mei3 is normally required to inactivate the Pat1 kinase (a negative regulator of Mei2) thereby allowing Mei2 to drive meiosis...
  80. ncbi Cohesin and recombination proteins influence the G1-to-S transition in azygotic meiosis in Schizosaccharomyces pombe
    Eveline Doll
    Institute of Cell Biology, University of Berne, CH 3012 Berne, Switzerland
    Genetics 180:727-40. 2008
    ..Finally, differences between azygotic meiosis and two other types of fission yeast meiosis (zygotic and pat1-114 meiosis) are discussed with respect to possible control steps in meiotic G(1).
  81. ncbi S. pombe pac1+, whose overexpression inhibits sexual development, encodes a ribonuclease III-like RNase
    Y Iino
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    EMBO J 10:221-6. 1991
    The Schizosaccharomyces pombe pac1 gene is a multicopy suppressor of the pat1 temperature-sensitive mutation, which directs uncontrolled meiosis at the restrictive temperature...
  82. ncbi Role of SLC26-mediated Cl-/base exchange in proximal tubule NaCl transport
    Peter S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Novartis Found Symp 273:148-58; discussion 158-63, 261-4. 2006
    ..We did find expression of SLC26A6 (CFEX, PAT1) on the apical membrane of proximal tubule cells, and demonstrated that SLC26A6 is capable of mediating the Cl-/..
  83. ncbi Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated
    Kaori Tanabe
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane 690 8504, Japan
    Eukaryot Cell 2:1274-87. 2003
    ..Strikingly, Sla1DeltaC induced haploid meiosis in a heterothallic strain, similar to the pat1-114 or mei2-SATA mutation...
  84. ncbi ARA67/PAT1 functions as a repressor to suppress androgen receptor transactivation
    Yanqing Zhang
    Department of Pathology, Urology, and Radiation Oncology and Cancer Center, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Cell Biol 24:1044-57. 2004
    ..Here we report the identification and characterization of ARA67/PAT1 as an AR coregulator from a prostate cDNA library...
  85. ncbi Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice
    Robert W Freel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, 32610 00275, USA
    Am J Physiol Gastrointest Liver Physiol 290:G719-28. 2006
    ..Urinary oxalate excretion was about fourfold greater in KO mice compared with WT littermates. We conclude that PAT1 is DIDS sensitive and mediates a significant fraction of oxalate efflux across the apical membrane in exchange for ..
  86. ncbi Immediate-early and delayed cytokinin response genes of Arabidopsis thaliana identified by genome-wide expression profiling reveal novel cytokinin-sensitive processes and suggest cytokinin action through transcriptional cascades
    Wolfram G Brenner
    Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, D 14195 Berlin, Germany
    Plant J 44:314-33. 2005
    ..A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, ..
  87. ncbi Kinetics of bidirectional H+ and substrate transport by the proton-dependent amino acid symporter PAT1
    Martin Foltz
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Center of Life and Food Sciences, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Federal Republic of Germany
    Biochem J 386:607-16. 2005
    b>PAT1 is a recently identified member of the PAT family of proton/amino acid co-transporters with predominant expression in the plasma membrane of enterocytes and in lysosomal membranes of neurons...
  88. ncbi Role of PDZK1 in membrane expression of renal brush border ion exchangers
    R Brent Thomson
    Department of Internal Medicine and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Proc Natl Acad Sci U S A 102:13331-6. 2005
    Na-H exchanger NHE3 and Cl-anion exchanger CFEX (SLC26A6, PAT1) play principal roles in the reabsorption of Na and Cl in the proximal tubule of the mammalian kidney...
  89. ncbi Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent
    Roger T Worrell
    Epithelial Pathobioloby Group, Dept of Surgery, University of Cincinnati, OH 45219, USA
    Am J Physiol Gastrointest Liver Physiol 289:G768-78. 2005
    ..for the apical anion exchangers SLC26A3 [downregulated in adenoma (DRA)] and SLC26A6 [putative anion transporter (PAT1)] were detected in T84 cells by RT-PCR and Northern and Western blots...
  90. ncbi Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)
    Catriona M H Anderson
    Faculty of Medical Sciences, Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 204:604-13. 2005
    ..This carrier, hPAT1 (human Proton-coupled Amino acid Transporter 1) or SLC36A1, has been identified recently at the molecular level and hPAT1 protein is localised to the brush border membrane ..
  91. ncbi Dissociation of the Nuf2-Ndc80 complex releases centromeres from the spindle-pole body during meiotic prophase in fission yeast
    Haruhiko Asakawa
    Cell Biology Group and CREST Research Project, Kansai Advanced Research Center, National Institute of Information and Communications Technology, Kobe 651 2492, Japan
    Mol Biol Cell 16:2325-38. 2005
    ..When cells are induced to meiosis by inactivation of Pat1 kinase (a key negative regulator of meiosis), centromeres remain associated with the SPB during meiotic prophase...
  92. ncbi Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target
    Søren Kjaerulff
    Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, DK 1353 Copenhagen K, Denmark
    Mol Cell Biol 25:2045-59. 2005
    ..Since Mei3 is normally needed for inactivation of the meiosis-repressing protein kinase Pat1, this finding suggests that the strong Byr2 signal causes inactivation of Pat1 by an alternative mechanism...
  93. ncbi The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1
    Isabel Rubio-Aliaga
    Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 279:2754-60. 2004
    ..PAT2 and its paralog, PAT1/LYAAT-1, are transporters for small amino acids such as glycine, alanine, and proline...
  94. ncbi H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
    David T Thwaites
    Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Exp Physiol 92:603-19. 2007
    ..membrane include: the di/tripeptide transporter PepT1 (SLC15A1); the proton-coupled amino-acid transporter PAT1 (SLC36A1); the divalent metal transporter DMT1 (SLC11A2); the organic anion transporting polypeptide OATP2B1 (SLC02B1); ..
  95. ncbi Light-signalling pathways leading to the co-ordinated expression of HEMA1 and Lhcb during chloroplast development in Arabidopsis thaliana
    Alex C McCormac
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Plant J 32:549-59. 2002
    ..The hy1, hy2, hy5, fin219, fhy1, fhy3, spa1, ndpk2, and pat1 mutants also affect light regulation of both HEMA1 and Lhcb expression, but with differences in the relative ..
  96. ncbi Sequence diversity of mating-type genes in Phaeosphaeria avenaria
    Peter P Ueng
    Molecular Plant Pathology Laboratory, U S Department of Agriculture, ARS, Beltsville, MD 20705, USA
    Curr Genet 43:121-30. 2003
    ..avenaria f. sp. triticea (Pat) and P. avenaria f. sp. avenaria (Paa). The Pat subspecies was grouped into Pat1-Pat3, based on restriction fragment length polymorphism (RFLP) and ribosomal DNA (rDNA) internal transcribed spacer ..
  97. ncbi Translational control in early development: CPEB, P-bodies and germinal granules
    Nancy Standart
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Biochem Soc Trans 36:671-6. 2008
    ..large RNP (ribonucleoprotein) complex and interacts with other RNA-binding proteins including Xp54 RNA helicase, Pat1, RAP55 (RNA-associated protein 55) and FRGY2 (frog germ cell-specific Y-box protein 2), as well as the eIF4E (..
  98. ncbi Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5
    Anurag Kumar Singh
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Kidney Int 74:438-47. 2008
    ..NaCl and water absorption which was significantly decreased in mice whose apical chloride/base exchanger Slc26a6 (PAT1, CFEX) was knocked out...
  99. ncbi Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast
    Ayumu Yamamoto
    CREST Research Project, Kansai Advanced Research Center, Communications Research Laboratory, 588 2 Iwaoka, Iwaoka cho, Nishi ku, Kobe 651 2492, Japan
    EMBO J 22:2284-96. 2003
    ..This monopolar attachment requires both mating pheromone signaling and inactivation of Pat1 kinase (a key negative regulator of meiosis)...
  100. ncbi A cluster of proton/amino acid transporter genes in the human and mouse genomes
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Genomics 82:47-56. 2003
    ..In the human and mouse genomes the genes of the PAT transporters (designated SLC36A1-3 and Slc36a1-3, respectively) are clustered on human chromosome 5q33...
  101. ncbi Assessment of hypolipidaemic activity of three thiazolidin-4-ones in mice given high-fat diet and fructose
    Gopalan Kutty Nampurath
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Madhava Nagar, Manipal, Karnataka, India
    Chem Biol Interact 171:363-8. 2008
    Three 4-thiazolidinones, two with nicotinamide (NAT1 and NAT2) and one with 4-chlorophenoxyacetamide (PAT1) side chains were evaluated for their hypolipidaemic, hypoglycaemic activity in Swiss albino mice fed a high-fat diet along with ..

Research Grants59

  1. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep Dudeja; Fiscal Year: 2009
    ..coli (EPEC); 2. Dissect out the role of DRA and PAT1 in activation of Cl-/OH-(HCO3-) exchange activity by Lactobacilli and elucidate signaling and molecular trafficking ..
  2. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2010
    ..coli (EPEC);2. Dissect out the role of DRA and PAT1 in activation of Cl-/OH-(HCO3-) exchange activity by Lactobacilli and elucidate signaling and molecular trafficking ..
  3. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2010
    ..coli (EPEC);2. Dissect out the role of DRA and PAT1 in activation of Cl-/OH-(HCO3-) exchange activity by Lactobacilli and elucidate signaling and molecular trafficking ..
  4. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    ..upon our studies using wild type (WT) and knockout (KO) mice, we have identified two key anion exchangers, namely PAT1 (slc26a6) and DRA (slc26a3), that contribute significantly to the movements of oxalate in the intestine and we ..
  5. Genetic Models for Disorders of Acid-Base Transport
    Gary E Shull; Fiscal Year: 2010
    ..anhydrase activity and coupled to transport of other ions by Na/H exchangers (NHE1-4), Cl/HCO exchangers (AE1-4, PAT1, DRA), Na- HCO3 cotransporters (NBCe1, NBCe2), H,K-ATPases, and others...
  6. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..One gene (SLC26A6), termed PAT1 is abundantly expressed in the apical membrane of small intestine and proximal tubule and is presumed to be ..
  7. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..One gene (SLC26A6), termed PAT1 is abundantly expressed in the apical membrane of small intestine and proximal tubule and is presumed to be ..
  8. LIGHT RESPONSIVE GENES
    Nam Hai Chua; Fiscal Year: 2006
    ..The other mutant we will analyze is pat1, which belongs to the plant-specific GRAS family of signal regulators...
  9. MRNA DECAPPING IN YEAST
    Roy Parker; Fiscal Year: 2007
    ..II) Analyze P-body assembly. III) Analyze the function of the Dhh1 and Pat1 proteins. IV) Determine if P-bodies function in other aspects of cytoplasmic mRNA physiology.
  10. Mouse Models for Ion Homeostasis Defects in Heart
    Gary E Shull; Fiscal Year: 2010
    Our objective is to understand the mechanisms by which the NHE1 Na/H exchanger and the AE1, AE2, AE3, and PAT1 (Slc4a1-3 and Slc26a6) Cl/HCO3 exchangers affect cardiac Ca handling, contractility, and metabolism...
  11. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation of cHKA will significantly enhance our knowledge on a variety of pathologic conditions associated with electrolyte and acid-base abnormalities. ..
  12. CHARACTERIZATION OF NA-DEPENDENT HCO3-TRANSPORTERS
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation and gene structure of Na-coupled HCO3 transporters should enhance our knowledge on cell regulation and acid-base homeostasis. ..
  13. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
    ..SLC26A6, also known as PAT1 or CFEX, is a member of a large, highly conserved family of ion transporters (designated as SLC26A) many of which ..
  14. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..abstract_text> ..
  15. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  16. GENETIC CONTROL OF SCHWANN CELL MYELINATION
    John Bermingham; Fiscal Year: 2005
    ..In the fourth Specific Aim, it is proposed to study postnatal functions of Oct-6 in peripheral myelination using mice that lack the gene only in Schwann cells. ..
  17. Role of the Yeast Lsm Proteins in mRNA Decay
    THARUN SUNDARESAN; Fiscal Year: 2007
    ..Owing to the homology of the Lsm1p-7p complex to the other Sm-like protein complexes in biology, these studies should also reveal some principles common to this family of protein complexes engaged in various RNA-related functions. ..
  18. Genetic Control of Schwann Cell Differentiation
    JOHN RUTLEDGE BERMINGHAM; Fiscal Year: 2011
    ..By understanding how the Lgi4 protein controls Schwann cell development, we will establish new avenues for the treatment of myelin disorders and nerve injury. ..
  19. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  20. Genetic Control of Schwann Cell Differentiation
    John Bermingham; Fiscal Year: 2009
    ..By understanding how the Lgi4 protein controls Schwann cell development, we will establish new avenues for the treatment of myelin disorders and nerve injury. ..
  21. Genetic Control of Schwann Cell Differentiation
    John Bermingham; Fiscal Year: 2007
    ..By understanding how the Lgi4 protein controls Schwann cell development, we will establish new avenues for the treatment of myelin disorders and nerve injury. ..
  22. Role of the Yeast Lsm Proteins in mRNA Decay
    THARUN SUNDARESAN; Fiscal Year: 2009
    ..abstract_text> ..
  23. Role of the Yeast Lsm Proteins in mRNA Decay
    THARUN SUNDARESAN; Fiscal Year: 2010
    ..abstract_text> ..