Gene Symbol: SLC34A2
Description: solute carrier family 34 member 2
Alias: NAPI-3B, NAPI-IIb, NPTIIb, sodium-dependent phosphate transport protein 2B, sodium/phosphate cotransporter 2B, solute carrier family 34 (sodium phosphate), member 2, solute carrier family 34 (type II sodium/phosphate cotransporter), member 2, type II sodium-dependent phosphate transporter 3b
Species: human
Products:     SLC34A2

Top Publications

  1. Feild J, Zhang L, Brun K, Brooks D, Edwards R. Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine. Biochem Biophys Res Commun. 1999;258:578-82 pubmed
    ..This novel transporter, designated human NaPi-3b (Genbank AF111856), appears to be an isoform of the mammalian renal type II co-transporter family. ..
  2. Corut A, Senyigit A, Ugur S, Altin S, Ozcelik U, Calisir H, et al. Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. Am J Hum Genet. 2006;79:650-6 pubmed publisher
    ..mapping to 4p15, then identified, by a candidate-gene approach, the gene responsible for the disease as SLC34A2 (the type IIb sodium-phosphate cotransporter gene), which is involved in phosphate homeostasis in several organs...
  3. Collins J, Scheving L, Ghishan F. Decreased transcription of the sodium-phosphate transporter gene in the hypophosphatemic mouse. Am J Physiol. 1995;269:F439-48 pubmed
    ..02% decreased rate of transcription of the Na(+)-Pi transporter gene in the Hyp mice (n = 3). Thus abnormal transcriptional control of this gene in the Hyp mouse likely plays a role in X-linked hypophosphatemia...
  4. Soares I, Simões K, de Souza J, Okamoto O, Wakamatsu A, Tuma M, et al. In silico analysis and immunohistochemical characterization of NaPi2b protein expression in ovarian carcinoma with monoclonal antibody Mx35. Appl Immunohistochem Mol Morphol. 2012;20:165-72 pubmed
    ..This identification of subgroups of patients expressing NaPi2b may be important in selecting cohorts who most likely should be included in future clinical trials, as a recently generated humanized version of MX35 has been developed. ..
  5. Shyian M, Gryshkova V, Kostianets O, Gorshkov V, Gogolev Y, Goncharuk I, et al. Quantitative analysis of SLC34A2 expression in different types of ovarian tumors. Exp Oncol. 2011;33:94-8 pubmed
    The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors...
  6. Chen D, Chien S, Kuo S, Teng Y, Tsai H, Kuo J, et al. SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer. Anticancer Res. 2010;30:4135-40 pubmed
    The purpose of this study was to estimate the role of the SLC34A2 gene in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues...
  7. Kiyamova R, Shyian M, Lyzogubov V, Usenko V, Gout T, Filonenko V. Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues. Exp Oncol. 2011;33:157-61 pubmed
  8. Zheng X, Kammerer C, Cox L, Morrison A, Turner S, Ferrell R. Association of SLC34A2 variation and sodium-lithium countertransport activity in humans and baboons. Am J Hypertens. 2009;22:288-93 pubmed publisher
    ..Human SLC34A2, located at chromosome 4p15.1-p15.3, is a positional candidate gene for SLC...
  9. Gałeza Kulik M, Zebracka J, Szpak Ulczok S, Czarniecka A, Kukulska A, Gubała E, et al. [Expression of selected genes involved in transport of ions in papillary thyroid carcinoma]. Endokrynol Pol. 2006;57 Suppl A:26-31 pubmed
    ..The aim of our study was a real-time PCR evaluation of three of them: KCNJ2, SLC4A4 and SLC34A2. The analysis was carried out in PTC tumors and normal thyroid samples gained from 38 patients...

More Information


  1. Xu H, Bai L, Collins J, Ghishan F. Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2). Genomics. 1999;62:281-4 pubmed
    ..We have isolated a cDNA (HGMW-approved symbol SLC34A2) encoding a novel human small intestinal Na(+)-P(i) transporter...
  2. Amar A, Majmundar A, Ullah I, Afzal A, Braun D, Shril S, et al. Gene panel sequencing identifies a likely monogenic cause in 7% of 235 Pakistani families with nephrolithiasis. Hum Genet. 2019;138:211-219 pubmed publisher
    ..We examined the monogenic causes of NL in a novel geographic cohort and most frequently identified dominant mutations in the sodium-phosphate transporter SLC34A1 with functional validation. ..
  3. Dërmaku Sopjani M, Sopjani M, Saxena A, Shojaiefard M, Bogatikov E, Alesutan I, et al. Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. Cell Physiol Biochem. 2011;28:251-8 pubmed publisher
    ..Treatment of NaPi-IIa- or NaPi-IIb-expressing oocytes with Klotho protein similarly decreased Ip. In conclusion, Klotho down regulates both, renal (NaPi-IIa) and intestinal (NaPi-IIb) phosphate transporters. ..
  4. Forster I. The molecular mechanism of SLC34 proteins: insights from two decades of transport assays and structure-function studies. Pflugers Arch. 2019;471:15-42 pubmed publisher
    ..This review will focus on how our present understanding of their molecular mechanism has evolved in this period by highlighting the key experimental findings. ..
  5. Lederer E, Wagner C. Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associations. Pflugers Arch. 2019;471:137-148 pubmed publisher
    ..phosphate transporter NaPi-IIa (SLC34A1) is mostly expressed in kidney, whereas NaPi-IIb (SLC34A2) has a wider tissue distribution with prominent expression in the lung and small intestine...
  6. Neel D, Allegakoen D, Olivas V, Mayekar M, Hemmati G, Chatterjee N, et al. Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019;79:546-556 pubmed publisher
    ..SDC4-ROS1 and SLC34A2-ROS1 fusion oncoproteins resided on endosomes and activated the MAPK pathway...
  7. Marks J. The role of SLC34A2 in intestinal phosphate absorption and phosphate homeostasis. Pflugers Arch. 2019;471:165-173 pubmed publisher
  8. Dandan S, Yuqin C, Wei L, Ziheng P, Dapeng Z, Jianzhu Y, et al. Novel deletion of SLC34A2 in Chinese patients of PAM shares mutation hot spot with fusion gene SLC34A2-ROS1 in lung cancer. J Genet. 2018;97:939-944 pubmed
    ..Mutation of the SLC34A2 gene was proved to be responsible for PAM. Here, we report the study of a family affected by PAM in China...
  9. Gong B, Oh hara T, Fujita N, Katayama R. 3D culture system containing gellan gum restores oncogene dependence in ROS1 rearrangements non-small cell lung cancer. Biochem Biophys Res Commun. 2018;501:527-533 pubmed publisher
    ..Publicly available NSCLC cell lines harboring the ROS1 fusion gene are limited to only HCC78 cells carrying SLC34A2-ROS1...
  10. Liu L, Yang Y, Zhou X, Yan X, Wu Z. Solute carrier family 34 member 2 overexpression contributes to tumor growth and poor patient survival in colorectal cancer. Biomed Pharmacother. 2018;99:645-654 pubmed publisher
    Solute carrier family 34 member 2 (SLC34A2) is a well-known sodium-dependent phosphate transporter that has recently been linked to cancer development...
  11. Huber K, Zeller E, Rodehutscord M. Modulation of small intestinal phosphate transporter by dietary supplements of mineral phosphorus and phytase in broilers. Poult Sci. 2015;94:1009-17 pubmed publisher
    ..Protein expression of NaPi IIb, NaPi type III (PiT1) and the calcium channel TRPV6 were semiquantitatively measured by Western blotting and ..
  12. Cheng H, Ye L, Xue L. [Detection of ROS1 gene rearrangement by FISH and analysis of its clinical features in non-small cell lung cancer patients]. Zhonghua Zhong Liu Za Zhi. 2014;36:751-4 pubmed
    ..2%) from the 1 652 NSCLC tissues. Among these positive cases, 15 were CD74-ROS1, 13 were SLC34A2-ROS1, 13 were SDC4-ROS1 and 12 were TPM3-ROS1...
  13. Li X, Xing J, Wang H, Yu E. The SLC34A2-ROS-HIF-1-induced upregulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer. Biosci Rep. 2018;: pubmed publisher
    Growing evidence has uncovered that SLC34A2 plays an evident role in the progression in several types of tumors. However, the biological function and underlying molecular mechanisms of SLC34A2 remain largely unknown...
  14. Lindskog C, Fagerberg L, Hallström B, Edlund K, Hellwig B, Rahnenführer J, et al. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. FASEB J. 2014;28:5184-96 pubmed publisher
    ..Transcript levels of 10 genes (SFTPB, SFTPC, SFTPD, SLC34A2, LAMP3, CACNA2D2, AGER, EMP2, NKX2-1, and NAPSA) were significantly associated with survival in the ..
  15. Sopjani M, Rinnerthaler M, Almilaji A, Ahmeti S, Dërmaku Sopjani M. Regulation of cellular transport by klotho protein. Curr Protein Pept Sci. 2014;15:828-35 pubmed
    ..Future studies will help to determine if the Klotho protein regulates cell-surface expression of other transport proteins and is affecting underlying mechanisms. ..
  16. Magagnin S, Werner A. Expression cloning human and rat renal cortex Na/Pi cotransporters: behind the scenes in the Murer laboratory. Pflugers Arch. 2019;471:7-14 pubmed publisher
    ..Expression cloning elegantly combined functional protein expression in Xenopus laevis oocytes with molecular biology to overcome the lack of molecular probes. ..
  17. Cargnelutti M, Corso S, Pergolizzi M, Mévellec L, Aisner D, Dziadziuszko R, et al. Activation of RAS family members confers resistance to ROS1 targeting drugs. Oncotarget. 2015;6:5182-94 pubmed
    ..mechanisms of resistance to ROS1 inhibitors we generated resistant cells from HCC78 lung cancer cells bearing the SLC34A2-ROS1 rearrangement...
  18. Fenollar Ferrer C, Forrest L. Structural models of the NaPi-II sodium-phosphate cotransporters. Pflugers Arch. 2019;471:43-52 pubmed publisher
    ..We discuss future opportunities, as well as the challenges that remain. ..
  19. Hernando N, Myakala K, Simona F, Knöpfel T, Thomas L, Murer H, et al. Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation. J Bone Miner Res. 2015;30:1925-37 pubmed publisher
    The Na(+) -dependent phosphate-cotransporter NaPi-IIb (SLC34A2) is widely expressed, with intestine, lung, and testis among the organs with highest levels of mRNA abundance...
  20. Muscher Banse A, Breves G. Mechanisms and regulation of epithelial phosphate transport in ruminants: approaches in comparative physiology. Pflugers Arch. 2019;471:185-191 pubmed publisher
    ..out in the jejunum by the apical located secondary active Na+-dependent Pi transporters NaPi IIb (SLC34A2) and PiT1 (SLC20A1)...
  21. Song A, Kim T, Kim D, Kim S, Keam B, Lee S, et al. Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer. Clin Cancer Res. 2015;21:2379-87 pubmed publisher
    ..tumors from two NSCLC patients with the CD74-ROS1 rearrangement, and in HCC78 cells harboring SLC34A2-ROS1 that showed resistance to crizotinib (HCC78CR cells)...
  22. Albano G, Moor M, Dolder S, Siegrist M, Wagner C, Biber J, et al. Sodium-dependent phosphate transporters in osteoclast differentiation and function. PLoS ONE. 2015;10:e0125104 pubmed publisher
  23. Lacerda Abreu M, Russo Abrahão T, Monteiro R, Rumjanek F, Meyer Fernandes J. Inorganic phosphate transporters in cancer: Functions, molecular mechanisms and possible clinical applications. Biochim Biophys Acta Rev Cancer. 2018;1870:291-298 pubmed publisher
    ..Altered expression levels of inorganic phosphate transporters, such as NaPi-IIb (SLC34A2) and PiT-1 (SLC20A1), have been demonstrated...
  24. Møller M, Kirkeby S, Vikeså J, Nielsen F, Cayé Thomasen P. Gene expression in the human endolymphatic sac: the solute carrier molecules in endolymphatic fluid homeostasis. Otol Neurotol. 2015;36:915-22 pubmed publisher
    ..transporter, SLC9a2 sodium-hydrogen transporter, SLC12a3 thiazide-sensitive Na-Cl transporter, and SLC34a2 sodium-phosphate transporter...
  25. Clavé S, Gimeno J, Muñoz Mármol A, Vidal J, Reguart N, Carcereny E, et al. ROS1 copy number alterations are frequent in non-small cell lung cancer. Oncotarget. 2016;7:8019-28 pubmed publisher
    ..To characterize ROS1 partners, probes for CD74, EZR, SLC34A2 and SDC3 genes were developed. ROS1 positive FISH cases were screened also by IHC...
  26. Stefanello C, Vieira S, Xue P, Ajuwon K, Adeola O. Age-related energy values of bakery meal for broiler chickens determined using the regression method. Poult Sci. 2016;95:1582-90 pubmed publisher
    ..Based on these results, utilization of energy and nitrogen in the basal diet decreased when bakery meal was included and increased with age of broiler chickens. ..
  27. Ratcliffe S, Jugdaohsingh R, Vivancos J, Marron A, Deshmukh R, Ma J, et al. Identification of a mammalian silicon transporter. Am J Physiol Cell Physiol. 2017;312:C550-C561 pubmed publisher
    ..Here we report the identification of a mammalian efflux Si transporter, namely Slc34a2 (also termed NaPiIIb), a known sodium-phosphate cotransporter, which was upregulated in rat kidney following ..
  28. Roskoski R. ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers. Pharmacol Res. 2017;121:202-212 pubmed publisher
    ..The ROS1 fusion partners include CD74, CCDC6, EZR, FIG, KDELR2, LRIG3, MSN, SDC4, SLC34A2, TMEM106B, TMP3, and TPD52L1...
  29. Castellana G, Castellana G, Gentile M, Castellana R, Resta O. Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide. Eur Respir Rev. 2015;24:607-20 pubmed publisher
    ..It is caused by mutation of the SLC34A2 gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells...
  30. Shiozaki Y, Segawa H, Ohnishi S, Ohi A, Ito M, Kaneko I, et al. Relationship between sodium-dependent phosphate transporter (NaPi-IIc) function and cellular vacuole formation in opossum kidney cells. J Med Invest. 2015;62:209-18 pubmed publisher
    ..In addition, mutations of NaPi-IIc (S138F and R468W) in HHRH did not cause cellular PIP2-rich vacuoles. In conclusion, our data anticipate that NaPi-IIc may regulate PIP2 production at the plasma membrane and cellular vesicle formation. ..
  31. Chen P, Huang Y, Bayir A, Wang C. Characterization of the isoforms of type IIb sodium-dependent phosphate cotransporter (Slc34a2) in yellow catfish, Pelteobagrus fulvidraco, and their vitamin D3-regulated expression under low-phosphate conditions. Fish Physiol Biochem. 2017;43:229-244 pubmed publisher
    In this study, two isoforms slc34a2 genes (type IIb sodium-dependent phosphate cotransporter), slc34a2a2 and slc34a2b, were cloned from intestine and kidney of yellow catfish (Pelteobagrus fulvidraco), with rapid amplification of cDNA ..
  32. Xue P, Ajuwon K, Adeola O. Phosphorus and nitrogen utilization responses of broiler chickens to dietary crude protein and phosphorus levels. Poult Sci. 2016;95:2615-2623 pubmed
    ..Supplementation of protein may be necessary in diets during P digestibility studies to ameliorate an effect of protein deficiency on P digestion and retention. ..
  33. Lin K, Rubinfeld B, Zhang C, Firestein R, Harstad E, Roth L, et al. Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers. Clin Cancer Res. 2015;21:5139-50 pubmed publisher
    ..Here, we have appended monomethyl auristatin E (MMAE) to an antibody recognizing the SLC34A2 gene product NaPi2b, the type II sodium-phosphate cotransporter, which is highly expressed on tumor surfaces of ..
  34. Chen P, Tang Q, Wang C. Characterizing and evaluating the expression of the type IIb sodium-dependent phosphate cotransporter (slc34a2) gene and its potential influence on phosphorus utilization efficiency in yellow catfish (Pelteobagrus fulvidraco). Fish Physiol Biochem. 2016;42:51-64 pubmed publisher
    A sodium-dependent phosphate cotransporter gene, NaPi-IIb (slc34a2), was isolated from yellow catfish (Pelteobagrus fulvidraco) intestine through homology cloning and the rapid amplification of cDNA ends...
  35. Liu S, Liao X, Lu L, Li S, Wang L, Zhang L, et al. Dietary non-phytate phosphorus requirement of broilers fed a conventional corn-soybean meal diet from 1 to 21 d of age. Poult Sci. 2017;96:151-159 pubmed
    ..39% for broiler chicks fed a conventional corn-soybean meal diet from 1 to 21 d of age. ..
  36. Sopjani M, Dërmaku Sopjani M. Klotho-Dependent Cellular Transport Regulation. Vitam Horm. 2016;101:59-84 pubmed publisher
    ..Clearly, further experimental efforts are required to investigate the effect of Klotho on other transport proteins and underlying molecular mechanisms by which Klotho exerts its effect. ..
  37. Katsumata Y, Kajiya H, Okabe K, Fukushima T, Ikebe T. A salmon DNA scaffold promotes osteogenesis through activation of sodium-dependent phosphate cotransporters. Biochem Biophys Res Commun. 2015;468:622-8 pubmed publisher
    ..cell cultures upregulated the expression of sodium-dependent phosphate (NaPi) cotransporters, SLC20A1 and SLC34A2, in MC3T3-E1 cells in a time dependent manner...
  38. Saito A, Nikolaidis N, Amlal H, Uehara Y, Gardner J, Lasance K, et al. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Sci Transl Med. 2015;7:313ra181 pubmed publisher
    ..Inactivating mutations in SLC34A2, which encodes the NPT2b sodium-dependent phosphate cotransporter, has been proposed as a cause of PAM...
  39. Otani N, Ouchi M, Hayashi K, Jutabha P, Anzai N. Roles of organic anion transporters (OATs) in renal proximal tubules and their localization. Anat Sci Int. 2017;92:200-206 pubmed publisher
  40. Soleimani M, Barone S, Xu J, Alshahrani S, Brooks M, McCormack F, et al. Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting. PLoS ONE. 2016;11:e0159804 pubmed publisher
  41. Patti M, Fenollar Ferrer C, Werner A, Forrest L, Forster I. Cation Interactions and Membrane Potential Induce Conformational Changes in NaPi-IIb. Biophys J. 2016;111:973-88 pubmed publisher
    ..To test this hypothesis by functional analysis, double mutants of the flounder SLC34A2 protein were constructed that contain one of the Na1-site perturbing mutations together with a substituted ..
  42. Aniteli T, de Siqueira F, dos Reis L, Dominguez W, de Oliveira E, Castelucci P, et al. Effect of variations in dietary Pi intake on intestinal Pi transporters (NaPi-IIb, PiT-1, and PiT-2) and phosphate-regulating factors (PTH, FGF-23, and MEPE). Pflugers Arch. 2018;470:623-632 pubmed publisher
    ..Uremia may be a determining factor that explains the expressional modulation of the cotransporters in the small intestine segments. ..
  43. Miao Z, Zhang G, Zhang J, Li J, Yang Y. Effect of early dietary energy restriction and phosphorus level on subsequent growth performance, intestinal phosphate transport, and AMPK activity in young broilers. PLoS ONE. 2017;12:e0186828 pubmed publisher
    ..This series of events stimulates NaPi-IIb mRNA expression. Our findings provide a theoretical basis and a new perspective on intestinal phosphate transport regulation, with potential applications in broiler production...
  44. Li Y, Chen X, Lu H. Knockdown of SLC34A2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Invasion. Oncol Res. 2016;24:511-519 pubmed publisher
    The gene solute carrier family 34 (sodium phosphate), member 2 (SLC34A2), is a member of the SLC34 family. Increasing evidence suggests that SLC34A2 is involved in the development of many human carcinomas...
  45. Yang W, Wang Y, Pu Q, Ye S, Ma Q, Ren J, et al. Elevated expression of SLC34A2 inhibits the viability and invasion of A549 cells. Mol Med Rep. 2014;10:1205-14 pubmed publisher
    Abnormal expression of solute carrier family 34 (sodium phosphate), member 2 (SLC34A2) in the lung may induce abnormal alveolar type II (AT II) cells to transform into lung adenocarcinoma cells, and may also be important in biological ..
  46. Xu H, Uno J, Inouye M, Collins J, Ghishan F. NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene. Am J Physiol Gastrointest Liver Physiol. 2005;288:G175-81 pubmed
    ..This study has thus identified a new target gene in the small intestinal epithelium that is directly regulated by NF1 transcriptional factor(s). ..
  47. Knopfel T, Pastor Arroyo E, Schnitzbauer U, Kratschmar D, Odermatt A, Pellegrini G, et al. The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction. Sci Rep. 2017;7:11018 pubmed publisher
    NaPi-IIb/Slc34a2 is a Na+-dependent phosphate transporter that accounts for the majority of active phosphate transport into intestinal epithelial cells...
  48. Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, et al. Growth-related renal type II Na/Pi cotransporter. J Biol Chem. 2002;277:19665-72 pubmed
    ..The finding of the present study suggest that the type IIc is a growth-related renal Na/P(i) cotransporter, which has a high affinity for P(i) and is electroneutral. ..
  49. Zhang Z, Ye S, Zhang M, Wu J, Yan H, Li X, et al. High expression of SLC34A2 is a favorable prognostic marker in lung adenocarcinoma patients. Tumour Biol. 2017;39:1010428317720212 pubmed publisher
    Dysregulation of SLC34A2 (NaPi2b) in tumors has attracted wide attention, but its expression and function in non-small cell lung cancer remains unclear...
  50. Homann V, Rosin Steiner S, Stratmann T, Arnold W, Gaengler P, Kinne R. Sodium-phosphate cotransporter in human salivary glands: molecular evidence for the involvement of NPT2b in acinar phosphate secretion and ductal phosphate reabsorption. Arch Oral Biol. 2005;50:759-68 pubmed
    ..These findings suggest a secondary active secretion of phosphate into the primary saliva. Ductal cells appear to be able to reabsorb phosphate, thereby modifying the phosphate concentration in the final saliva. ..
  51. Mengel From J, Børsting C, Sanchez J, Eiberg H, Morling N. Human eye colour and HERC2, OCA2 and MATP. Forensic Sci Int Genet. 2010;4:323-8 pubmed publisher
    ..Diplotype analysis of three sequence variations in HERC2 and one sequence variation in OCA2 showed the best discrimination between light and dark eye colours with a likelihood ratio of 29.3. ..
  52. Jönsson Å, Hilberg O, Bendstrup E, Mogensen S, Simonsen U. SLC34A2 gene mutation may explain comorbidity of pulmonary alveolar microlithiasis and aortic valve sclerosis. Am J Respir Crit Care Med. 2012;185:464 pubmed
  53. Liu X, Zhou X, Xu H, He Z, Shi X, Wu S. SLC34A2 Regulates the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells Through PTEN/PI3K/AKT Signaling. DNA Cell Biol. 2017;36:775-780 pubmed publisher
    ..In this study, we showed that SLC34A2, a member of the solute carrier gene family, was significantly downregulated in OS patients and cell lines...
  54. Ye W, Chen C, Gao Y, Zheng Z, Xu Y, Yun M, et al. Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity. Cell Death Dis. 2017;8:e2581 pubmed publisher
    Solute carrier family 34 member 2 (SLC34A2), a pH-sensitive sodium-dependent phosphate transporter, is associated with several human cancers...
  55. Yang Y, Qiao J, An J, Zhang Y, Yu T, Jia B, et al. [Detection of SLC34A2 in patients with pulmonary alveolar microlithiasis and the effect of SLC34A2 on transportation of calcium and phosphate in human alveolar epithelial cells]. Zhonghua Jie He He Hu Xi Za Zhi. 2008;31:908-11 pubmed
    To detect the mutation of SLC34A2 in patients with pulmonary alveolar microlithiasis and to study the effect of SLC34A2 on transportation of calcium and phosphate in human alveolar epithelial cell (A549) cells...
  56. Kiyamova R, Gryshkova V, Ovcharenko G, Lituyev D, Malyuchik S, Usenko V, et al. Development of monoclonal antibodies specific for the human sodium-dependent phosphate co-transporter NaPi2b. Hybridoma (Larchmt). 2008;27:277-84 pubmed publisher
    ..These properties make them particularly valuable reagents for elucidating NaPi2b function in health and disease. ..
  57. Frei P, Gao B, Hagenbuch B, Mate A, Biber J, Murer H, et al. Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver. Am J Physiol Gastrointest Liver Physiol. 2005;288:G771-8 pubmed
    ..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
  58. Collins J, Bulus N, Ghishan F. Sodium-phosphate transporter adaptation to dietary phosphate deprivation in normal and hypophosphatemic mice. Am J Physiol. 1995;268:G917-24 pubmed
    ..33-fold in Hyp mice). Immunoreactive protein levels increased 2.3 +/- 0.4-fold in normal mice and 8.2 +/- 0.5 in the Hyp mouse kidney cortexes (n = 3, P = 0.0001) in response to dietary P(i) deprivation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  59. Wang Y, Yang W, Pu Q, Yang Y, Ye S, Ma Q, et al. The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer. J Biomed Sci. 2015;22:52 pubmed publisher
    b>SLC34A2 with highest expressions in lung, small intestine and kidney encoded a type 2b sodium-dependent phosphate transporter (NaPi-IIb)...
  60. Fezai M, Elvira B, Warsi J, Ben Attia M, Hosseinzadeh Z, Lang F. Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1. Kidney Blood Press Res. 2015;40:555-64 pubmed publisher
    ..SPAK and/or OSR1 contributes to the regulation of the intestinal Na(+)-coupled phosphate co-transporter NaPi-IIb (SLC34A2)...
  61. Xu H, Uno J, Inouye M, Xu L, Drees J, Collins J, et al. Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen. Am J Physiol Gastrointest Liver Physiol. 2003;285:G1317-24 pubmed
    ..This stimulation is associated with increased NaPi-IIb mRNA and protein expression. Thus the effect of estrogen on intestinal Pi absorption may be partially due to activation of NaPi-IIb gene transcription. ..
  62. Huqun -, Izumi S, Miyazawa H, Ishii K, Uchiyama B, Ishida T, et al. Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med. 2007;175:263-8 pubmed
    ..We identified a candidate gene, SLC34A2, that encodes a type IIb sodium phosphate cotransporter and that is mutated in six of six patients investigated...
  63. Piton N, Ruminy P, Gravet C, Marchand V, Colasse É, Lamy A, et al. Ligation-dependent RT-PCR: a new specific and low-cost technique to detect ALK, ROS, and RET rearrangements in lung adenocarcinoma. Lab Invest. 2017;: pubmed publisher
    ..gene partner: EML4 in all cases), 9 rearrangements (64%) in the ROS1 cases (gene partners: CD74 in 8 cases and SLC34A2 in 1 case) and 1 (100%) in the single RET case (gene partner: KIF5B)...
  64. Zhong Y, Hu C, Cai X, Nie H. [A novel mutation of the SLC34A2 gene in a Chinese pedigree with pulmonary alveolar microlithiasis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:365-8 pubmed
    To identify the mutation of solute carrier family 34 member 2 (SLC34A2) gene in a Chinese family with pulmonary alveolar microlithiasis (PAM). Genomic DNA was extracted from the family members...
  65. Zhang L, Guo X, Zhang L, Yang F, Qin L, Zhang D, et al. SLC34A2 regulates miR-25-Gsk3? signaling pathway to affect tumor progression in gastric cancer stem cell-like cells. Mol Carcinog. 2017;: pubmed publisher
    ..Here, we aim to investigate biological function of SLC34A2 in regulating sphere formation and tumorigenicity (both are the hallmark of CSCs) of GCSCs and its underlying ..
  66. Tachibana T, Hagiwara K, Johkoh T. Pulmonary alveolar microlithiasis: review and management. Curr Opin Pulm Med. 2009;15:486-90 pubmed publisher
    ..The responsible gene, the mutation of which is associated with PAM, has been identified as SLC34A2. Characteristic chest computed tomography (CT) findings in patients with PAM have been shown to correlate well ..
  67. Lv Y, Wang T, Fan J, Zhang Z, Zhang J, Xu C, et al. The effects and mechanisms of SLC34A2 on maintaining stem cell-like phenotypes in CD147+ breast cancer stem cells. Tumour Biol. 2017;39:1010428317695927 pubmed publisher
    ..In this study, we aim to investigate the biological function of SLC34A2 in affecting the stem cell-like phenotypes in BCSCs and its underlying mechanisms...
  68. Zhang J, Xu Y, Gao Y, Chen C, Zheng Z, Yun M, et al. Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway. Mol Cancer. 2017;16:18 pubmed publisher
    ..We further identified solute carrier family 34 member 2 (SLC34A2) was a novel target of miR-939...
  69. Dogan O, Ozsahin S, Gul E, Arslan S, Koksal B, Berk S, et al. A frame-shift mutation in the SLC34A2 gene in three patients with pulmonary alveolar microlithiasis in an inbred family. Intern Med. 2010;49:45-9 pubmed
    ..The SLC34A2 is thought to be responsible for the disease. We encountered three siblings of an inbred family who have PAM...
  70. Jiang Z, Hao Y, Ding X, Zhang Z, Liu P, Wei X, et al. The effects and mechanisms of SLC34A2 on tumorigenicity in human non-small cell lung cancer stem cells. Tumour Biol. 2016;37:10383-92 pubmed publisher
    ..Here, we aim to investigate biological function of SLC34A2 in regulating tumorigenicity of LCSCs and its underlying mechanisms...
  71. Levan K, Mehryar M, Mateoiu C, Albertsson P, Bäck T, Sundfeldt K. Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b. BMC Cancer. 2017;17:303 pubmed publisher
    ..The gene and protein expression of SLC34A2/NaPi2b were analyzed in ovarian carcinoma tissues by QPCR (n = 73) and immunohistochemistry (n = 136)...
  72. Zhang X, Ke X, Pu Q, Yuan Y, Yang W, Luo X, et al. MicroRNA-410 acts as oncogene in NSCLC through downregulating SLC34A2 via activating Wnt/β-catenin pathway. Oncotarget. 2016;7:14569-85 pubmed publisher
    b>SLC34A2 had been reported to be down-regulated in human NSCLC cells and patient tissues, and played a significant role in lung cancer. However, the mechanism of its unusual expressionin NSCLC has not been fully elucidated...
  73. Ge G, Zhou C, Ren Y, Tang X, Wang K, Zhang W, et al. Enhanced SLC34A2 in breast cancer stem cell-like cells induces chemotherapeutic resistance to doxorubicin via SLC34A2-Bmi1-ABCC5 signaling. Tumour Biol. 2016;37:5049-62 pubmed publisher
    ..We aim to investigate the relationship between SLC34A2 and chemoresistance in BCSCs and identify the underlying mechanisms by which SLC34A2 regulates chemoresistance in ..
  74. Xu H, Inouye M, Missey T, Collins J, Ghishan F. Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes. Biochim Biophys Acta. 2002;1567:97-105 pubmed
  75. Werner A, Kinne R. Evolution of the Na-P(i) cotransport systems. Am J Physiol Regul Integr Comp Physiol. 2001;280:R301-12 pubmed
    ..We hypothesize that the original NaPi-IIb-related gene was duplicated early in vertebrate development. The appearance of NaPi-IIa correlates with the development of the mammalian nephron...
  76. Xu H, Collins J, Bai L, Kiela P, Ghishan F. Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor. Am J Physiol Cell Physiol. 2001;280:C628-36 pubmed
    ..We conclude that the human NaP(i)-IIb gene promoter is functional in Caco-2 and A549 cells and that the gene is responsive to EGF by a transcriptionally mediated mechanism in intestinal cells...
  77. Yin X, Wang H, Wu D, Zhao G, Shao J, Dai Y. SLC34A2 Gene mutation of pulmonary alveolar microlithiasis: report of four cases and review of literatures. Respir Med. 2013;107:217-22 pubmed publisher
    ..Currently the mutation of SLC34A2 gene was considered responsible for PAM...
  78. Lopes dos Santos M, Yeda F, Tsuruta L, Horta B, Pimenta A, Degaki T, et al. Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer. PLoS ONE. 2013;8:e70332 pubmed publisher
    ..To explore use of this antibody in clinical trials, GMP production of Rebmab200 has been initiated. As the next step of development, Phase I clinical trials are now planned for translation of Rebmab200 into the clinic. ..