Gene Symbol: SLC31A1
Description: solute carrier family 31 member 1
Alias: COPT1, CTR1, high affinity copper uptake protein 1, copper transport 1 homolog, copper transporter 1, solute carrier family 31 (copper transporter), member 1, solute carrier family 31 (copper transporters), member 1
Species: human
Products:     SLC31A1

Top Publications

  1. Lee J, Petris M, Thiele D. Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. J Biol Chem. 2002;277:40253-9 pubmed
    ..Previously, we reported that overexpression of the human or mouse Ctr1 copper transporter stimulates copper uptake in mammalian cells, and deletion of one Ctr1 allele in mice gives rise ..
  2. Wu Z, Liu Q, Liang X, Yang X, Wang N, Wang X, et al. Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1. J Biol Inorg Chem. 2009;14:1313-23 pubmed publisher
    ..Human copper transporter 1 (hCtr1), a copper influx protein, was recently found to facilitate the cellular entry of several platinum ..
  3. Tsigelny I, Sharikov Y, Greenberg J, Miller M, Kouznetsova V, Larson C, et al. An all-atom model of the structure of human copper transporter 1. Cell Biochem Biophys. 2012;63:223-34 pubmed publisher
    Human copper transporter 1 (hCTR1) is the major high affinity copper influx transporter in mammalian cells that also mediates uptake of the cancer chemotherapeutic agent cisplatin...
  4. Kuo M, Fu S, Savaraj N, Chen H. Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy. Cancer Res. 2012;72:4616-21 pubmed publisher
    The high-affinity copper transporter (Ctr1; SCLC31A1) plays an important role in regulating copper homeostasis because copper is an essential micronutrient and copper deficiency is detrimental to many important cellular functions, but ..
  5. Zimnicka A, Maryon E, Kaplan J. Human copper transporter hCTR1 mediates basolateral uptake of copper into enterocytes: implications for copper homeostasis. J Biol Chem. 2007;282:26471-80 pubmed
  6. Molloy S, Kaplan J. Copper-dependent recycling of hCTR1, the human high affinity copper transporter. J Biol Chem. 2009;284:29704-13 pubmed publisher
    ..Copper-dependent internalization and recycling of hCTR1 provides an acute and reversible mechanism for the regulation of cellular copper entry. ..
  7. Lee J, Pena M, Nose Y, Thiele D. Biochemical characterization of the human copper transporter Ctr1. J Biol Chem. 2002;277:4380-7 pubmed
    ..Here, we demonstrate that human Ctr1 (hCtr1) is a component of the copper transport machinery at the plasma membrane...
  8. Klomp A, Tops B, Van Denberg I, Berger R, Klomp L. Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1). Biochem J. 2002;364:497-505 pubmed
    The human copper transporter 1 gene (hCTR1) was previously identified by functional complementation in ctr1-deficient yeast...
  9. Eisses J, Kaplan J. Molecular characterization of hCTR1, the human copper uptake protein. J Biol Chem. 2002;277:29162-71 pubmed
    ..The high level of functional expression and the low level of endogenous copper uptake will enable future structure-function analysis of this important protein. ..

More Information

Publications117 found, 100 shown here

  1. Eisses J, Chi Y, Kaplan J. Stable plasma membrane levels of hCTR1 mediate cellular copper uptake. J Biol Chem. 2005;280:9635-9 pubmed
    The human copper transporter 1 (hCtr1), when heterologously overexpressed in insect cells, mediates saturable Cu uptake...
  2. Schushan M, Barkan Y, Haliloglu T, Ben Tal N. C(alpha)-trace model of the transmembrane domain of human copper transporter 1, motion and functional implications. Proc Natl Acad Sci U S A. 2010;107:10908-13 pubmed publisher
    The trimeric human copper transporter 1 (hCTR1) is essential for copper uptake and is implicated in sensitivity to chemotherapy drugs...
  3. Bertinato J, Cheung L, Hoque R, Plouffe L. Ctr1 transports silver into mammalian cells. J Trace Elem Med Biol. 2010;24:178-84 pubmed publisher
    ..Previous studies have shown that copper uptake at the plasma membrane by copper transporter 1 (Ctr1) is inhibited by an excess of silver, suggesting that Ctr1 may function in importing silver into ..
  4. Nose Y, Wood L, Kim B, Prohaska J, Fry R, Spears J, et al. Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. J Biol Chem. 2010;285:32385-92 pubmed publisher
    ..The Ctr1 protein is a high-affinity Cu(+) importer that is structurally and functionally conserved in yeast, plants, fruit ..
  5. Zhou B, Gitschier J. hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc Natl Acad Sci U S A. 1997;94:7481-6 pubmed
    ..of a human gene involved in this process by complementation of the yeast high-affinity copper uptake mutant, ctr1. Besides complementing ctr1 growth defect on nonfermentable media, the human gene also rescues iron transport and ..
  6. Puig S, Lee J, Lau M, Thiele D. Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. J Biol Chem. 2002;277:26021-30 pubmed
    ..In this report, we elucidate the topological orientation of the yeast Ctr1 copper transport protein...
  7. De Feo C, Aller S, Siluvai G, Blackburn N, Unger V. Three-dimensional structure of the human copper transporter hCTR1. Proc Natl Acad Sci U S A. 2009;106:4237-42 pubmed publisher
    ..Here, we report the structure of the human CTR1 protein solved by electron crystallography to an in plane resolution of 7 A...
  8. Crider S, Holbrook R, Franz K. Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1. Metallomics. 2010;2:74-83 pubmed publisher
    ..The copper transport protein Ctr1 is responsible for high affinity copper uptake but has also been implicated in the transport of cisplatin into ..
  9. Maryon E, Molloy S, Kaplan J. Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1. Am J Physiol Cell Physiol. 2013;304:C768-79 pubmed publisher
    Copper is an essential micronutrient. Following entry via the human copper transporter 1 (hCTR1), copper is delivered to several copper chaperones, which subsequently transfer the metal to specific targets via protein:protein interactions...
  10. Shi T, Sun J, Wu X, Weng J, Wang P, Qie H, et al. Transcriptome analysis of Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit treated with heat and 1-MCP. Plant Physiol Biochem. 2018;133:40-49 pubmed publisher
    ..during the postharvest stage and were decreased by heat and 1-MCP treatment, and serine/threonine-protein kinase 1 (CTR1) was also repressed by treatment...
  11. Guo S, Zheng J, Yuan S, Zhu Q. Effects of heat and cadmium exposure on stress-related responses in the liver of female zebrafish: Heat increases cadmium toxicity. Sci Total Environ. 2018;618:1363-1370 pubmed publisher
    ..Finally, heat down-regulated Zir-, Irt-like protein 8 (ZIP8) and copper transporter 1 (CTR1) and up-regulated metallothioneins (MTs) in Cd-exposed fish, possibly suggesting Cu and Zn depletion ..
  12. Chatterjee P, Yeboah M, Solanki M, Kumar G, Xue X, Pavlov V, et al. Activation of the cholinergic anti-inflammatory pathway by GTS-21 attenuates cisplatin-induced acute kidney injury in mice. PLoS ONE. 2017;12:e0188797 pubmed publisher
    ..05). GTS-21 suppressed the expression of CTR1, a cisplatin influx transporter and enhanced the expression of cisplatin efflux transporters MRP2, MRP4, and MRP6 (..
  13. Han M, Chang J, Kim J. Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity. J Neurochem. 2016;138:918-28 pubmed publisher
    ..Quantitative PCR analysis showed that both copper importer copper transporter 1 and exporter copper-transporting ATPase 1 were up-regulated in the hippocampus from b/b rats...
  14. Arciello M, Longo A, Viscomi C, Capo C, Angeloni A, Rossi L, et al. Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty acids overload. Biometals. 2015;28:1017-29 pubmed publisher
    ..that, in hepatoma cell lines, core domain mutant Y220C of p53 affects the modulation of SCO2 and Copper transporter 1 (CTR1), influencing, in this way, intracellular copper homeostasis in presence of FFAs accumulation, and ..
  15. Southon A, Greenough M, Hung Y, Norgate M, Burke R, Camakaris J. The ADP-ribosylation factor 1 (Arf1) is involved in regulating copper uptake. Int J Biochem Cell Biol. 2011;43:146-53 pubmed publisher
    ..b>Ctr1 levels at the plasma membrane of cultured fibroblast cells were reduced following Arf1 knockdown, indicating an ..
  16. Miyayama T, Ishizuka Y, Iijima T, Hiraoka D, Ogra Y. Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis. Metallomics. 2011;3:693-701 pubmed publisher
    ..CCS knockdown significantly decreased Ctr1, a Cu influx transporter, mRNA expression...
  17. Besouw M, Schneider J, Janssen M, Greco M, Emma F, Cornelissen E, et al. Copper deficiency in patients with cystinosis with cysteamine toxicity. J Pediatr. 2013;163:754-60 pubmed publisher
    ..Serum copper and ceruloplasmin levels and urinary copper/creatinine ratio were measured. Genes ATP7A and CTR1 (encoding copper transporters), LOX (encoding lysyl oxidase), and COL1A1 and COL1A2 (encoding type I procollagen) ..
  18. Park Y, Lian H, Chang M, Kang C, Yun C. Identification of high-affinity copper transporters in Aspergillus fumigatus. Fungal Genet Biol. 2014;73:29-38 pubmed publisher
    ..Four putative copper transporters were identified in the A. fumigatus genome; ctrA2 and ctrC complemented CTR1 functionally and localized to the plasma membrane in Saccharomyces cerevisiae...
  19. Costas Rodríguez M, Van Campenhout S, Hastuti A, Devisscher L, Van Vlierberghe H, Vanhaecke F. Body distribution of stable copper isotopes during the progression of cholestatic liver disease induced by common bile duct ligation in mice. Metallomics. 2019;: pubmed publisher largely mediated by transporters of Cu(i), mRNA and protein expression levels of two major metal transporters (CTR1 and DMT1) and Cu reductases (STEAP proteins and duodenal cytochrome B) were examined in the duodenal tissues as ..
  20. Safi R, Nelson E, Chitneni S, Franz K, George D, Zalutsky M, et al. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Res. 2014;74:5819-31 pubmed publisher
    ..Furthermore, we determined that prostate cancer cells express high levels of CTR1, the primary copper transporter, and additional chaperones that are required to maintain intracellular copper ..
  21. Lee J, Ahn C, Kang H, Hong E, Hyun S, Choi K, et al. Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas. Int J Environ Res Public Health. 2016;13: pubmed
    ..b>CTR1 (solute carrier family 31, member 1) and ATP7A (ATPase, Cu++ transporting, alpha polypeptide) expression ..
  22. Contreras Cornejo H, López Bucio J, Méndez Bravo A, Macías Rodríguez L, Ramos Vega M, Guevara García Ã, et al. Mitogen-Activated Protein Kinase 6 and Ethylene and Auxin Signaling Pathways Are Involved in Arabidopsis Root-System Architecture Alterations by Trichoderma atroviride. Mol Plant Microbe Interact. 2015;28:701-10 pubmed publisher
    ..atroviride. Increased MPK6 activity was evidenced in roots of ctr1 mutants, which correlated with repression of primary root growth, thus connecting MPK6 signaling with an ET ..
  23. Piulats J, Vidal A, García Rodríguez F, Muñoz C, Nadal M, Moutinho C, et al. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Clin Cancer Res. 2018;24:3755-3766 pubmed publisher
    ..1 gain. Moreover, other four genes (GCS, ZNF883, CTR1, and FLJ31713) were deregulated in all five resistant tumors independently of the 9q32-q33...
  24. Alidori S, Akhavein N, Thorek D, Behling K, Romin Y, Queen D, et al. Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury. Sci Transl Med. 2016;8:331ra39 pubmed publisher
    ..compared to siRNA alone and effectively knocked down the expression of several target genes, includingTrp53,Mep1b,Ctr1, andEGFP A clinically relevant cisplatin-induced murine model of AKI was used to evaluate the therapeutic potential ..
  25. Masaldan S, Clatworthy S, Gamell C, Smith Z, Francis P, Denoyer D, et al. Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy. Redox Biol. 2018;16:322-331 pubmed publisher
    ..Elevated copper in senescent MEFs was accompanied by elevated levels of high-affinity copper uptake protein 1 (Ctr1), diminished levels of copper-transporting ATPase 1 (Atp7a) (copper export) and enhanced antioxidant defence ..
  26. Shin K, Lee S, Song W, Lee R, Lee I, Ha K, et al. Genetic identification of ACC-RESISTANT2 reveals involvement of LYSINE HISTIDINE TRANSPORTER1 in the uptake of 1-aminocyclopropane-1-carboxylic acid in Arabidopsis thaliana. Plant Cell Physiol. 2015;56:572-82 pubmed publisher
    ..showed that the ethylene-overproducing mutations, eto1 or eto3, and the constitutive ethylene signaling mutation, ctr1 were epistatic to the are2 mutation...
  27. Anandhan A, Rodriguez Rocha H, Bohovych I, Griggs A, Zavala Flores L, Reyes Reyes E, et al. Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiol Dis. 2015;81:76-92 pubmed publisher
    ..Cell death induced by Cu was potentiated by overexpression of the Cu transporter protein 1 (Ctr1) and depletion of intracellular glutathione (GSH) indicating that the toxic effects of Cu are linked to alterations ..
  28. Perea García A, Andrés Bordería A, Mayo de Andrés S, Sanz A, Davis A, Davis S, et al. Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana. J Exp Bot. 2016;67:391-403 pubmed publisher
    ..The alteration of copper homeostasis in the COPT1 overexpression line and spl7 mutants also modified the amplitude of a classical clock output, namely the circadian ..
  29. Berterame N, Martani F, Porro D, Branduardi P. Copper homeostasis as a target to improve Saccharomyces cerevisiae tolerance to oxidative stress. Metab Eng. 2018;46:43-50 pubmed publisher
    ..Therefore, we investigated the effect of the alteration of copper homeostasis on cellular stress tolerance. CTR1 and FRE1 genes, codifying for a plasma membrane high-affinity copper transporter and for a cell-surface ferric/..
  30. Lutsenko S, Bhattacharjee A, Hubbard A. Copper handling machinery of the brain. Metallomics. 2010;2:596-608 pubmed publisher
    ..copper homeostasis, despite the fact that the molecules mediating copper transport and distribution in the brain (CTR1, Atox1, CCS, ScoI/II, ATP7A and ATP7B) have been identified and their importance in CNS function increasingly ..
  31. Xiao T, Ackerman C, Carroll E, Jia S, Hoagland A, Chan J, et al. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat Chem Biol. 2018;14:655-663 pubmed publisher
    ..sleep, arousal, attention, memory and emotion, as a copper-enriched unit with high levels of copper transporters CTR1 and ATP7A and the copper enzyme dopamine β-hydroxylase (DBH) that produces NE...
  32. Sundaresan S, Philosoph Hadas S, Riov J, Belausov E, Kochanek B, Tucker M, et al. Abscission of flowers and floral organs is closely associated with alkalization of the cytosol in abscission zone cells. J Exp Bot. 2015;66:1355-68 pubmed publisher
    ..Examination of the pH changes in the AZ cells of Arabidopsis mutants defective in both ethylene-induced (ctr1, ein2, eto4) and ethylene-independent (ida, nev7, dab5) abscission pathways confirmed these results...
  33. Jadot M, Boonen M, Thirion J, Wang N, Xing J, Zhao C, et al. Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome. Mol Cell Proteomics. 2017;16:194-212 pubmed publisher
    ..The latter included copper transporter 1, encoded by SLC31A1, which we localized to both the plasma membrane and lysosome...
  34. Chen S, Kuo C, Pan H, Tsou T, Yeh S, Chang J. Mechanistic basis of a combination D-penicillamine and platinum drugs synergistically inhibits tumor growth in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo. Biochem Pharmacol. 2015;95:28-37 pubmed publisher
  35. Manohar S, Leung N. Cisplatin nephrotoxicity: a review of the literature. J Nephrol. 2018;31:15-25 pubmed publisher
    ..entry into a cell is facilitated by a number of cellular transporters including human copper transport protein 1 (Ctr1) and the organic cation transporter 2 (OCT2) which are expressed on renal tubular cells...
  36. Wang C, Liang X, Tao C, Yao X, Wang Y, Wang Y, et al. Induction of copper and iron in acute cold-stimulated brown adipose tissues. Biochem Biophys Res Commun. 2017;488:496-500 pubmed publisher
    ..Furthermore, the significantly increased Cu and Fe contents and the markedly up-regulated CTR1 and ATP7A expression in acute cold-stimulated BAT indicates the involvement of both Cu and Fe in the BAT-mediated ..
  37. Espinoza A, Le Blanc S, Olivares M, Pizarro F, Ruz M, Arredondo M. Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA. Biol Trace Elem Res. 2012;146:281-6 pubmed publisher
    ..To determine the involvement of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) on Fe, Cu, and Zn uptake, Caco-2 cells were transfected with four different shRNA plasmids to ..
  38. Hong K, Jin H, Song D, Kwak H, Kim S, Kim Y. Genome-wide association study of serum albumin:globulin ratio in Korean populations. J Hum Genet. 2013;58:174-7 pubmed publisher
    ..These 38 signals were tested in the Ansung population. Eleven SNPs from six loci (GALNT2, IRF4, HLA-DBP1, SLC31A1, FADS1 and TNFRSF13B) were replicated, with P-values<0.05...
  39. Leng X, Mu Q, Wang X, Li X, Zhu X, Shangguan L, et al. Transporters, chaperones, and P-type ATPases controlling grapevine copper homeostasis. Funct Integr Genomics. 2015;15:673-84 pubmed publisher
    ..The expression patterns indicated that CTr1, CTr2, and CTr8 transporters were significantly upregulated in response both to Cu excess and deficiency...
  40. Schwab S, Shearer J, Conklin S, Alies B, Haas K. Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2. J Inorg Biochem. 2016;158:70-76 pubmed publisher
    The critical nature of the copper transporter 1 (Ctr1) in human health has spurred investigation of Ctr1 structure and function. Ctr1 specifically transports Cu(I), the reduced form of copper, across the plasma membrane...
  41. Akerfeldt M, Tran C, Shen C, Hambley T, New E. Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells. J Biol Inorg Chem. 2017;22:765-774 pubmed publisher understanding the mechanisms by which platinum-based anticancer agents enter cells, and the copper transporter CTR1 has been the focus of many recent studies...
  42. Tennant A, Rauk A, Wieser M. Computational modelling of the redistribution of copper isotopes by proteins in the liver. Metallomics. 2017;9:1809-1819 pubmed publisher
    ..It was not possible to calculate the reduced partition function of CTR1 as a high resolution crystal structure of its copper binding domains are unavailable at the time of writing, and an ..
  43. Fujie T, Murakami M, Yoshida E, Tachinami T, Shinkai Y, Fujiwara Y, et al. Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells. J Biol Inorg Chem. 2016;21:263-73 pubmed publisher
    ..was reduced by small interfering RNA (siRNA)-mediated knockdown of the copper transporter CTR1, the knockdown did not affect Cu10 accumulation, indicating that Cu10 rapidly enters vascular endothelial cells via ..
  44. Logeman B, Wood L, Lee J, Thiele D. Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2. J Biol Chem. 2017;292:11531-11546 pubmed publisher
    ..Although mammalian Ctr1 functions as a Cu+ transporter for Cu acquisition and is essential for embryonic development, a ..
  45. Ponnandai Shanmugavel K, Petranovic D, Wittung Stafshede P. Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast. Metallomics. 2017;9:981-988 pubmed publisher
    After Ctr1-mediated uptake into human cells, copper (Cu) ions are transported by the cytoplasmic Cu chaperone Atox1 to the Wilson disease protein (ATP7B) in the Golgi network...
  46. Zhang H, Wu X, Mehmood K, Chang Z, Li K, Jiang X, et al. Intestinal epithelial cell injury induced by copper containing nanoparticles in piglets. Environ Toxicol Pharmacol. 2017;56:151-156 pubmed publisher
    ..stress markers were assayed by differential expression levels of SOD, MDA and Metallothionein (MT) in addition to CTR1, SOD1, COX17, MT and ATOX1 genes expression...
  47. Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, et al. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A?42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013;34:2604-12 pubmed publisher
    ..Early manipulation of brain copper uptake can have a great effect on A? pathology. ..
  48. Urso E, Maffia M. Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems. J Vasc Res. 2015;52:172-96 pubmed publisher
    ..Functions regulated by the major copper transport proteins (CTR1 importer, ATP7A efflux pump and metallo-chaperones) include the modulation of endothelial migration and vascular ..
  49. Wachsmann J, Peng F. Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma. World J Gastroenterol. 2016;22:221-31 pubmed publisher
    ..In addition to copper modulation therapy with copper chelators, short-interference RNA specific for human copper transporter 1 (hCtr1) may be used to suppress growth of HCC by blocking increased copper uptake mediated by hCtr1...
  50. Vittorio O, Brandl M, Cirillo G, Kimpton K, Hinde E, Gaus K, et al. Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth. Oncotarget. 2016;7:47479-47493 pubmed publisher
    ..b>Copper transporter 1 (CTR1) is the main transporter of copper in mammalian cells and it is upregulated in neuroblastoma...
  51. Nilse L, Avci D, Heisterkamp P, Serang O, Lemberg M, Schilling O. Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1. Biochim Biophys Acta. 2016;1864:1363-71 pubmed publisher
    ..As an exemplary application, we show the identification of the copper transporter Ctr1 as a putative substrate of the ER-intramembrane protease Ypf1 by yeast membrane proteomics using d3-leucine ..
  52. Comstra H, McArthy J, Rudin Rush S, Hartwig C, Gokhale A, Zlatic S, et al. The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors. elife. 2017;6: pubmed publisher
    ..COG null cells possess altered content and subcellular localization of ATP7A and CTR1 (SLC31A1), the transporter required for copper uptake, as well as decreased total cellular copper, and impaired copper-..
  53. Jiang L, Song D, Chen H, Zhang A, Wang H, Cheng Z. Pilot Study of 64CuCl₂ for PET Imaging of Inflammation. Molecules. 2018;23: pubmed publisher
    Copper(II) ion (Cu2+) is the essential element for numerous pathophysiological processes in vivo. Copper transporter 1 (CTR1) is mainly responsible for maintaining Cu2+ accumulation in cells, which has been found to ..
  54. Pourvali K, Matak P, Latunde Dada G, Solomou S, Mastrogiannaki M, Peyssonnaux C, et al. Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2?. FEBS Lett. 2012;586:2423-7 pubmed publisher
    ..Here we investigated whether the intestinal copper importer Ctr1 was also regulated by hypoxia...
  55. Bulcke F, Dringen R. Handling of Copper and Copper Oxide Nanoparticles by Astrocytes. Neurochem Res. 2016;41:33-43 pubmed publisher
    ..Cultured astrocytes efficiently take up copper ions predominantly by the copper transporter Ctr1 and the divalent metal transporter DMT1...
  56. Alos E, Martinez Fuentes A, Reig C, Mesejo C, Rodrigo M, Agusti M, et al. Ethylene biosynthesis and perception during ripening of loquat fruit (Eriobotrya japonica Lindl.). J Plant Physiol. 2017;210:64-71 pubmed publisher
    ..biosynthesis (ACS1, ACO1 and ACO2), two ethylene receptors (ERS1a and ERS1b), one signal transduction component (CTR1) and one transcription factor (EIL1) in peel and pulp of loquat fruit during natural ripening and also in fruits ..
  57. Li T, Peng J, Zeng F, Zhang K, Liu J, Li X, et al. Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer. Int J Clin Pharmacol Ther. 2017;55:774-780 pubmed publisher
    The copper transporters <italic>CTR1</italic>, <italic>CTR2</italic>, <italic>ATP7A</italic>, and <italic>ATP7B</italic> regulate intracellular concentration of platinum by mediating its ..
  58. Yu L, Chen M, Gu C, Li Y, Wen J, Fu J, et al. [Cisplatin induces drug resistance in human esophageal squamous carcinoma cell line EC109 by decreasing CTR1 protein expression]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:801-4 pubmed
    ..Western blotting was used to investigate the protein expression of full length PARP, cleaved PARP, and copper transporter 1 (CTR1)...
  59. Przybyłkowski A, Gromadzka G, Wawer A, Grygorowicz T, Cybulska A, Członkowska A. Intestinal expression of metal transporters in Wilson's disease. Biometals. 2013;26:925-34 pubmed publisher
    ..It has been proposed that copper transporter 1 (CTR1) and the divalent metal transporter 1 (DMT1) translocate copper across the human intestinal ..
  60. Hsu K, Shen M, Huang Y, Cheng Y, Lin S, Chow N, et al. Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer. Br J Cancer. 2015;113:414-24 pubmed publisher
    ..Testing for a combination of elevated IMP3 and Lin28B levels could further facilitate the identification of a patient subgroup with the worst prognosis. ..
  61. Wu X, Yuan S, Wang E, Tong Y, Ma G, Wei K, et al. Platinum transfer from hCTR1 to Atox1 is dependent on the type of platinum complex. Metallomics. 2017;9:546-555 pubmed publisher
    ..The different reactivity is consistent with the hypothesis that hCTR1 is more significant in the transport of cisplatin than that of oxaliplatin. ..
  62. Chang C, Hu Y, Hogan S, Mercke N, Gomez M, O Bryant C, et al. Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin. Int J Mol Sci. 2017;18: pubmed publisher
    ..of cisplatin in renal tubule cells due to: (1) uptake by organic cation transporter 2 (OCT2) and copper transporter 1 (CTR1); (2) metabolism by glutathione S-transferases (GSTs) and γ-glutamyltransferase 1 (GGT1); and (3) ..
  63. Xu X, Ren H, Zhou B, Zhao Y, Yuan R, Ma R, et al. Prediction of copper transport protein 1 (CTR1) genotype on severe cisplatin induced toxicity in non-small cell lung cancer (NSCLC) patients. Lung Cancer. 2012;77:438-42 pubmed publisher
    ..Genetic variances of core genes also affect cisplatin toxicity. It has been identified that CTR1, copper transporter protein 1, plays an essential role in cisplatin uptake...
  64. Dong Z, Wang Y, Wang C, Xu H, Guan L, Li Z, et al. Self-Assembly of the Second Transmembrane Domain of hCtr1 in Micelles and Interaction with Silver Ion. J Phys Chem B. 2015;119:8302-12 pubmed publisher
    Human copper transporter 1 (hCtr1) transports copper and silver by a homotrimer. The protein contains three transmembrane domains in which the second transmembrane domain (TMD2) is a key component lining the central pore of the trimer...
  65. Ma G, Wu Q, Wu X, Arnesano F, Natile G, Sletten E, et al. The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex. J Inorg Biochem. 2015;153:239-246 pubmed publisher
    ..In this work, we investigated the reaction between platinated adducts of a methionine-rich motif of yeast CTR1 (Mets7) and N-acetyl-cysteine (AcCys) or N-acetyl-histidine (AcHis), mimicking metal-binding residues downstream ..
  66. Ratzon E, Najajreh Y, Salem R, Khamaisie H, Ruthardt M, Mahajna J. Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study. BMC Cancer. 2016;16:140 pubmed publisher
    ..The uptake of Cisplatin was reduced by 30% in A2780 in which the copper transporter-1 (Ctr1) was silenced...
  67. Saito Y, Okamoto K, Kobayashi M, Narumi K, Furugen A, Yamada T, et al. Magnesium co-administration decreases cisplatin-induced nephrotoxicity in the multiple cisplatin administration. Life Sci. 2017;189:18-22 pubmed publisher
    ..However, the expression of copper transporter 1 (rCtr1) was significantly downregulated after Mg co-administration...
  68. Lee S, Howell S, Opella S. NMR and mutagenesis of human copper transporter 1 (hCtr1) show that Cys-189 is required for correct folding and dimerization. Biochim Biophys Acta. 2007;1768:3127-34 pubmed
  69. Jiang P, Chen A, Wu X, Zhou M, Haq I, Mariyam Z, et al. NEAT1 acts as an inducer of cancer stem cell-like phenotypes in NSCLC by inhibiting EGCG-upregulated CTR1. J Cell Physiol. 2017;: pubmed publisher
    ..The copper transporter 1 (CTR1) has been the focus of many recent studies because of its correlation with cisplatin (CDDP) ..
  70. Guo Y, Smith K, Petris M. Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter: requirement for the extracellular methionine-rich clusters. J Biol Chem. 2004;279:46393-9 pubmed
    ..These studies provide the first evidence for a direct interaction between cisplatin and the hCtr1 protein and establish that cisplatin and copper have distinct biochemical consequences on this transporter...
  71. Haydon M, Mielczarek O, Frank A, Roman A, Webb A. Sucrose and Ethylene Signaling Interact to Modulate the Circadian Clock. Plant Physiol. 2017;175:947-958 pubmed publisher
    ..GI protein, dependent on the F-box protein ZEITLUPE, and implicate CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a negative regulator of ethylene signaling...
  72. Sankova T, Orlov I, Saveliev A, Kirilenko D, Babich P, Brunkov P, et al. The Extracellular Domain of Human High Affinity Copper Transporter (hNdCTR1), Synthesized by E. coli Cells, Chelates Silver and Copper Ions In Vivo. Biomolecules. 2017;7: pubmed publisher
    ..glutathione-S-transferase (GST) and the N-terminal domain (ectodomain) of human high affinity copper transporter CTR1 (hNdCTR1), which has three metal-bound motifs...
  73. Klomp A, Juijn J, van der Gun L, van den Berg I, Berger R, Klomp L. The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. Biochem J. 2003;370:881-9 pubmed
    ..studies and glycosylation-site insertion and deletion mapping to characterize the topology of human copper transporter 1 (hCTR1), the putative human high-affinity copper-import protein...
  74. Petris M, Smith K, Lee J, Thiele D. Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. J Biol Chem. 2003;278:9639-46 pubmed
    ..Our findings suggest that hCtr1-mediated copper uptake into mammalian cells is regulated by a post-translational mechanism involving copper-stimulated endocytosis and degradation of the transporter. ..
  75. Lanvers Kaminsky C, Sprowl J, Malath I, Deuster D, Eveslage M, Schlatter E, et al. Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity. Pharmacogenomics. 2015;16:323-32 pubmed publisher
    Assuming that genetic variants of the SLC22A2 and SLC31A1 transporter affect patients' susceptibility to cisplatin-induced ototoxicity, we compared the distribution of 11 SLC22A2 variants and the SLC31A1 variant rs10981694 between ..
  76. Kurokawa T, He G, Siddik Z. Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner. Cancer Chemother Pharmacol. 2010;65:427-36 pubmed publisher
    ..Knockdown of hCtr1 (the human copper transporter 1) by siRNA abrogated this inhibition in cisplatin uptake...
  77. Du X, Wang X, Li H, Sun H. Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCTR1). Metallomics. 2012;4:679-85 pubmed publisher
    b>Copper transporter 1 (CTR1) is a transmembrane protein that imports copper(i) into yeast and mammalian cells. Surprisingly, the protein also mediates the uptake of platinum anticancer drugs, e.g. cisplatin and carboplatin...
  78. Kidane T, Farhad R, Lee K, Santos A, Russo E, Linder M. Uptake of copper from plasma proteins in cells where expression of CTR1 has been modulated. Biometals. 2012;25:697-709 pubmed publisher
    ..studies on the mechanisms by which albumin and transcuprein deliver copper and the potential involvement of CTR1, rates of uptake from these proteins and Cu-histidine were compared in cells with/without CTR1 knockdown or ..
  79. Ogane N, Yasuda M, Kameda Y, Yokose T, Kato H, Itoh A, et al. Prognostic value of organic anion transporting polypeptide 1B3 and copper transporter 1 expression in endometrial cancer patients treated with paclitaxel and carboplatin. Biomed Res. 2013;34:143-51 pubmed
    ..Organic anion transporting polypeptide 1B3 (OATP1B3) and copper transporter 1 (CTR1) are critical for the uptake of paclitaxel and carboplatin, respectively...
  80. Zimnicka A, Tang H, Guo Q, Kuhr F, Oh M, Wan J, et al. Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS ONE. 2014;9:e90544 pubmed publisher
    ..In this study, we show that the Cu-uptake transporter 1, CTR1, and the Cu-efflux pump, ATP7A, were both upregulated in the lung tissues and pulmonary arteries of mice with ..
  81. Sørensen B, Dam C, Sturup S, Lambert I. Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells. J Inorg Biochem. 2016;160:287-95 pubmed publisher
    ..ovarian cancer cells (A2780) correlates with a reduced expression of LRRC8A and copper transporter receptor 1 (CTR1), as well as a concomitant increased expression of copper-transporting P-type ATPases (ATP7A/ATP7B)...
  82. Levy A, Yarmiayev V, Moskovitz Y, Ruthstein S. Probing the structural flexibility of the human copper metallochaperone Atox1 dimer and its interaction with the CTR1 c-terminal domain. J Phys Chem B. 2014;118:5832-42 pubmed publisher
    ..the interaction between the human copper chaperone Atox1 and the c-terminal domain of the copper transporter, CTR1, using electron paramagnetic resonance (EPR) spectroscopy and circular dichroism (CD)...
  83. Tsai C, Liebig J, Tsigelny I, Howell S. The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2). Metallomics. 2015;7:1477-87 pubmed publisher
    Mammalian cells have two influx Cu transporters that form trimers in membranes. CTR1 is the high affinity transporter that resides largely in the plasma membrane, and CTR2 is the low affinity transporter that is primarily associated with ..
  84. Clifford R, Maryon E, Kaplan J. Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu⁺ uptake system. J Cell Sci. 2016;129:1711-21 pubmed publisher
    Cu ion (Cu) entry into human cells is mediated by CTR1 (also known as SLC31A1), the high-affinity Cu transporter...
  85. Schneider V, Chaib S, Spanier C, Knapp M, Moscvin V, Scordovillo L, et al. Transporter-Mediated Interaction Between Platinum Drugs and Sorafenib at the Cellular Level. AAPS J. 2017;20:9 pubmed publisher
    ..In A2780 cells, the kinase inhibitor also decreased the expression of copper transporter 1 (CTR1)...
  86. Yuan S, Chen S, Xi Z, Liu Y. Copper-finger protein of Sp1: the molecular basis of copper sensing. Metallomics. 2017;9:1169-1175 pubmed publisher
    ..This result indicates that, in addition to apo-to-holo alteration, metal substitution can also lead to transcriptional switch in metal sensing. This work provides insight into the copper sensing mechanism of Sp1 at the molecular level. ..
  87. Baker Z, Jett K, Boulet A, Hossain A, Cobine P, Kim B, et al. The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Hum Mol Genet. 2017;26:4617-4628 pubmed publisher
    ..Interestingly, the reduction in copper content of Sco1stm/stm cardiomyocytes was due to the mislocalisation of CTR1, the high affinity transporter that imports copper into the cell...
  88. Aller S, Unger V. Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. Proc Natl Acad Sci U S A. 2006;103:3627-32 pubmed
    Human CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms...
  89. Narayanan G, R B, Vuyyuru H, Muthuvel B, Konerirajapuram Natrajan S. CTR1 silencing inhibits angiogenesis by limiting copper entry into endothelial cells. PLoS ONE. 2013;8:e71982 pubmed publisher
    ..b>Copper transporter 1 (CTR1) is a copper importer present in the cell membrane and plays a major role in copper transport...
  90. Chen S, Kuo C, Pan H, Tsou T, Yeh S, Chang J. Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo. Oncotarget. 2016;7:49310-49321 pubmed publisher
    ..Decrement of human copper transporter 1 (hCtr1) and transferrin receptor 1 (TfR1) expression involved in the development of platinum resistance in ..
  91. Groba S, Guttmann S, Niemietz C, Bernick F, Sauer V, Hachmöller O, et al. Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure. Metallomics. 2017;9:1279-1287 pubmed publisher
    ..Intracellular copper levels and the expression of MT1 and HSP70 were increased, whereas the expression of CTR1 was reduced. However, the values normalized after weaning...
  92. Freestone D, Cater M, Ackland M, Paterson D, Howard D, de Jonge M, et al. Copper and lactational hormones influence the CTR1 copper transporter in PMC42-LA mammary epithelial cell culture models. J Nutr Biochem. 2014;25:377-87 pubmed publisher
    ..lactating and suckled mammary epithelia were used to investigate the regulation of the copper uptake protein, CTR1. Both the degree of mammary epithelial differentiation (functionality) and extracellular copper concentration ..