Gene Symbol: SLC30A5
Description: solute carrier family 30 member 5
Alias: ZNT5, ZNTL1, ZTL1, ZnT-5, zinc transporter 5, solute carrier family 30 (zinc transporter), member 5, zinc transporter ZTL1, znT-like transporter 1
Species: human
Products:     SLC30A5

Top Publications

  1. Cragg R, Christie G, Phillips S, Russi R, Kury S, Mathers J, et al. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. J Biol Chem. 2002;277:22789-97 pubmed
    ..Unusually, the predicted topology comprises 12 rather than 6 transmembrane domains. ZTL1 mRNA was detected by reverse transcription-PCR in a range of mouse tissues...
  2. Fukunaka A, Suzuki T, Kurokawa Y, Yamazaki T, Fujiwara N, Ishihara K, et al. Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway. J Biol Chem. 2009;284:30798-806 pubmed publisher
    The majority of CDF/ZnT zinc transporters form homo-oligomers. However, ZnT5, ZnT6, and their orthologues form hetero-oligomers in the early secretory pathway where they load zinc onto zinc-requiring enzymes and maintain secretory pathway ..
  3. Kambe T, Narita H, Yamaguchi Iwai Y, Hirose J, Amano T, Sugiura N, et al. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem. 2002;277:19049-55 pubmed
    ..We have identified a novel mammalian zinc transporter, zinc transporter 5 (ZnT-5), by virtue of its similarity to ZRC1, a zinc transporter of Saccharomyces cerevisiae, a member of ..
  4. Thokala S, Bodiga V, Kudle M, Bodiga S. Comparative Response of Cardiomyocyte ZIPs and ZnTs to Extracellular Zinc and TPEN. Biol Trace Elem Res. 2019;: pubmed publisher
    ..TPEN downregulated ZnT1, ZnT2, and ZIP11 mRNAs but upregulated ZnT5, ZIP2, ZIP7, ZIP10, ZIP13, and ZIP14 mRNAs...
  5. Wang C, Si L, Guo S, Zheng J. Negative effects of acute cadmium on stress defense, immunity, and metal homeostasis in liver of zebrafish: The protective role of environmental zinc dpre-exposure. Chemosphere. 2019;222:91-97 pubmed publisher
    ..of il-6 and inos, and decreasing Cu/Zn-SOD and HSP70 levels, and mRNA levels of sod1, cat, hsp70, p65, mtf-1, znt5, zip7, atp7a, and atp7b...
  6. Wahono N, Ford D, Wakeling L, Valentine R. The presence and response to Zn of ZnT family mRNAs in human dental pulp. Metallomics. 2019;11:613-620 pubmed publisher
    ..ZnT1, ZnT5 and ZnT9 mRNAs were detected by RT-PCR in both the secretory odontoblast cells and human dental pulp...
  7. Nygaard S, Larsen A, Knuhtsen A, Rungby J, Smidt K. Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells. BMC Res Notes. 2014;7:84 pubmed publisher
    ..These results indicate that the β-cell-like function and survival of INS-1E cells are dependent on the surrounding zinc concentrations. Our results suggest that regulation of zinc homeostasis could represent a pharmacological target. ..
  8. Foster M, Chu A, Petocz P, Samman S. Zinc transporter gene expression and glycemic control in post-menopausal women with Type 2 diabetes mellitus. J Trace Elem Med Biol. 2014;28:448-52 pubmed publisher
    ..supplementation with zinc (40mg/d) and flaxseed oil (FSO; 2g/d) on the gene expression of zinc transporters (ZnT1, ZnT5, ZnT6, ZnT7, ZnT8, Zip1, Zip3, Zip7, and Zip10) and metallothionein (MT-1A, and MT-2A), and markers of glycemic ..
  9. Ogo O, Tyson J, Cockell S, Howard A, Valentine R, Ford D. The zinc finger protein ZNF658 regulates the transcription of genes involved in zinc homeostasis and affects ribosome biogenesis through the zinc transcriptional regulatory element. Mol Cell Biol. 2015;35:977-87 pubmed publisher
    ..Small interfering RNA (siRNA) targeted to ZNF658 abrogated the zinc-induced, ZTRE-dependent reduction in SLC30A5 (ZnT5 gene), SLC30A10 (ZnT10 gene), and CBWD transcripts in human Caco-2 cells and the ability of zinc to repress ..

More Information


  1. Petkovic V, Miletta M, Eblé A, Flück C, Mullis P. Alteration of ZnT5-mediated zinc import into the early secretory pathway affects the secretion of growth hormone from rat pituitary cells. Horm Res Paediatr. 2014;82:245-51 pubmed publisher
    ..b>Slc30a5 (ZnT5) was reported to have the highest gene expression among all zinc transporters in primary mouse pituitary ..
  2. Chen G, Luo Z, Wei C, Li D, Pan Y. Six indicator genes for zinc (Zn) homeostasis in freshwater teleost yellow catfish Pelteobagrus fulvidraco: molecular characterization, mRNA tissue expression and transcriptional changes to Zn exposure. Biometals. 2018;31:527-537 pubmed publisher
    ..This study cloned and characterized the full-length cDNA sequences of six Zn transport-relevant genes (ZnT1, ZnT5, ZnT7, ZIP4, ZIP5 and MTF-1) from yellow catfish Pelteobagrus fulvidraco...
  3. Barat A, Sahoo P, Kumar R, Pande V. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comp Biochem Physiol B Biochem Mol Biol. 2016;200:54-61 pubmed publisher
    ..The slc15a2, slc25a47, slc33a1 and slc38a2 were highly expressed in brain and slc30a5 was over-expressed in gill...
  4. Rafalo A, Zadrozna M, Nowak B, Kotarska K, Wiatrowska K, Pochwat B, et al. The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2017;72:36-48 pubmed publisher
    ..Messenger RNA and proteins of ZnT1, ZnT3, ZnT4, ZnT5, ZnT6 and MT1/2 were measured in the prefrontal cortex (PFC) and hippocampus (Hp) of rats subjected to olfactory ..
  5. Florea D, Molina López J, Hogstrand C, Lengyel I, de la Cruz A, Rodríguez Elvira M, et al. Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS). J Trace Elem Med Biol. 2018;49:202-209 pubmed publisher
    ..Expression of 11 out of 24 zinc transporters was analysed, and ZnT1, ZnT4, ZnT5 and ZIP4, which were downregulated by more than 3-fold in whole blood of patients...
  6. Tsuji T, Kurokawa Y, Chiche J, Pouysségur J, Sato H, Fukuzawa H, et al. Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters. J Biol Chem. 2017;292:2159-2173 pubmed publisher
    ..alkaline phosphatase (TNAP), which is elaborately activated by means of a two-step mechanism by zinc transporter 5 (ZNT5)-ZNT6 heterodimers and ZNT7 homodimers, through protein stabilization followed by enzyme activation ..
  7. Maares M, Keil C, Thomsen S, Gunzel D, Wiesner B, Haase H. Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport. J Trace Elem Med Biol. 2018;49:296-304 pubmed publisher
    ..However, FRET-measurements confirmed that these differences in expression levels have no effect on fractional zinc-saturation of the probe. ..
  8. Hennigar S, Kelley A, McClung J. Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review. Adv Nutr. 2016;7:735-46 pubmed publisher
    ..ZIP10 (SLC39A10), ZIP14 (SLC39A14), zinc transporter (ZnT)1 (SLC30A1), ZnT2 (SLC30A2), ZnT4 (SLC30A4), ZnT5 (SLC30A5), ZnT6 (SLC30A6), ZnT7 (SLC30A7), ZnT9 (SLC30A9), and/or metallothionein in various blood cells isolated from ..
  9. Ni H, Zhang L, Ren S, Sun B. Long-term expression of zinc transporters in hippocampus following penicillin-induced developmental seizures and its regulation by E-64d. Exp Ther Med. 2016;12:208-214 pubmed
    ..Thus, E-64d may offer a novel strategy for the development of therapeutic interventions for developmental seizure-induced brain damage. ..
  10. Hardyman J, Tyson J, Jackson K, Aldridge C, Cockell S, Wakeling L, et al. Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc. Metallomics. 2016;8:337-43 pubmed publisher
    ..model by overexpressing metallothionein and observing the predicted curtailment in response of the zinc-repressed SLC30A5 (ZnT5) promoter. The model provides the framework for an integrated understanding of cellular zinc homeostasis...
  11. Thornton J, Taylor K, Ford D, Valentine R. Differential subcellular localization of the splice variants of the zinc transporter ZnT5 is dictated by the different C-terminal regions. PLoS ONE. 2011;6:e23878 pubmed publisher
    ..Two splice variants of the human SLC30A5 Zn transporter gene (ZnT5) have been reported in the literature...
  12. Inoue K, Matsuda K, Itoh M, Kawaguchi H, Tomoike H, Aoyagi T, et al. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Hum Mol Genet. 2002;11:1775-84 pubmed
    ..It was identical to a gene encoding a zinc transporter, ZNT5, reported very recently by others...
  13. Chen G, Hogstrand C, Luo Z, Zhang D, Ling S, Wu K. Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr. 2017;118:570-579 pubmed publisher
    ..In the fore-intestine, dietary Zn up-regulated mRNA levels of ZnT1, ZnT5, ZnT7, metallothionein (MT) and metal response element-binding transcription factor-1 (MTF-1), but down-regulated ..
  14. Fujimoto S, Tsuji T, Fujiwara T, Takeda T, Merriman C, Fukunaka A, et al. The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation. Biochem J. 2016;473:2611-21 pubmed publisher
    ..through a two-step mechanism, via protein stabilization and subsequent enzyme activation through metalation, by ZnT5-ZnT6 heterodimers or ZnT7 homodimers...
  15. Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed
  16. Rafalo Ulinska A, Piotrowska J, Kryczyk A, Opoka W, Sowa Kucma M, Misztak P, et al. Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims. J Psychiatr Res. 2016;83:220-229 pubmed publisher
    ..Protein levels of ZnT1, ZnT3, ZnT4, ZnT5 and ZnT6 were measured in postmortem brain tissue from two different cohorts...
  17. Overbeck S, Uciechowski P, Ackland M, Ford D, Rink L. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol. 2008;83:368-80 pubmed
    ..These data provide insight into the regulation of intracellular zinc homeostasis in cells of the immune system and may explain the variable effects of zinc deficiency on different leukocyte subsets. ..
  18. Boughammoura S, Chemek M, Mimouna S, Banni M, Messaoudi I. Involvement of Zn Depletion in Cd-Induced Toxicity on Prenatal Bone Formation in Rat. Biol Trace Elem Res. 2017;180:70-80 pubmed publisher
    ..molecular level, Cd caused upregulation of MT-1 and ZIP2 genes and significantly depressed the expression of the ZnT5, col?1, osteocalcin, and ALP genes in the femur...
  19. Deng B, Zhou X, Wu J, Long C, Yao Y, Peng H, et al. Effects of dietary supplementation with tribasic zinc sulfate or zinc sulfate on growth performance, zinc content and expression of zinc transporters in young pigs. Anim Sci J. 2017;88:1556-1560 pubmed publisher
    ..on growth performance, serum zinc (Zn) content and messenger RNA (mRNA) expression of Zn transporters (ZnT1/ZnT2/ZnT5/ZIP4/DMT1) of young growing pigs...
  20. Zhang X, Liang D, Guo B, Deng W, Chi Z, Cai Y, et al. Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. Cell Signal. 2013;25:999-1010 pubmed publisher
    ..While many zinc transporters were constitutively expressed, ZnT5 mRNA and ZnT7 mRNA were strongly induced by HG...
  21. Zhu Q, Guo S, Yuan S, Lv Z, Zheng J, Xia H. Heat indicators of oxidative stress, inflammation and metal transport show dependence of cadmium pollution history in the liver of female zebrafish. Aquat Toxicol. 2017;191:1-9 pubmed publisher
    ..levels of IL-6, IL-1?, TNF-?, iNOS and NF-?B), 8 molecular indicators of metal transport (mRNA levels of, ZnT1, ZnT5, ZIP8, ZIP10, ATP7A, ATP7B and CTR1)...
  22. Malavolta M, Costarelli L, Giacconi R, Basso A, Piacenza F, Pierpaoli E, et al. Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. Exp Gerontol. 2017;99:35-45 pubmed publisher
    ..of labile Zn and altered expression of genes involved in the response to Zn toxicity, including SLC30A1, SLC39A6, SLC30A5, SLC30A10 and metallothioneins, indicating that senescent cells have altered zinc homeostasis...
  23. Hoch E, Lin W, Chai J, Hershfinkel M, Fu D, Sekler I. Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity. Proc Natl Acad Sci U S A. 2012;109:7202-7 pubmed publisher
  24. Fukunaka A, Kurokawa Y, Teranishi F, Sekler I, Oda K, Ackland M, et al. Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway. J Biol Chem. 2011;286:16363-73 pubmed publisher
    ..We have previously shown that two zinc transport complexes, ZnT5/ZnT6 heterodimers and ZnT7 homo-oligomers, are required for the activation of alkaline phosphatases, by converting ..
  25. Zhang L, Wang X, Stoltenberg M, Danscher G, Huang L, Wang Z. Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. Brain Res Bull. 2008;77:55-60 pubmed publisher
    ..In conclusion, our data provided significant morphological evidence of zinc ions and ZNTs being actively involved in the pathological processes that lead to plaque formation. ..
  26. Devergnas S, Chimienti F, Naud N, Pennequin A, Coquerel Y, Chantegrel J, et al. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Biochem Pharmacol. 2004;68:699-709 pubmed
  27. Lacourse K, Swanberg L, Gillespie P, Rehfeld J, Saunders T, Samuelson L. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol. 1999;276:G1302-9 pubmed
    ..Altered somatostatin concentrations in brain and duodenum of CCK-deficient mice suggest that other regulatory pathways are modified to compensate for the CCK deficiency. ..