SLC30A3

Summary

Gene Symbol: SLC30A3
Description: solute carrier family 30 member 3
Alias: ZNT3, zinc transporter 3, solute carrier family 30 (zinc transporter), member 3, zinc transporter ZnT-3, znT-3
Species: human
Products:     SLC30A3

Top Publications

  1. Salazar G, Love R, Werner E, Doucette M, Cheng S, Levey A, et al. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. Mol Biol Cell. 2004;15:575-87 pubmed
    ..We explored this hypothesis by analyzing the targeting of ZnT3 and synaptophysin both to PC12 synaptic-like microvesicles (SLMV) as well as SV isolated from wild-type and AP-3-..
  2. Palmiter R, Cole T, Quaife C, Findley S. ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A. 1996;93:14934-9 pubmed
    The murine ZnT3 gene was cloned by virtue of its homology to the ZnT2 gene, which encodes a membrane protein that facilitates sequestration of zinc in endosomal vesicles...
  3. Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed
    ..A survey of the expression and localization of zinc transporter (ZnT) family members identified ZnT2, ZnT3, and ZnT4 as likely mediators of vesicular zinc accumulation in M1 cells...
  4. Yang N, Li Y, Xiong T, Chen L, Zhai Y, Liang J, et al. Dexamethasone ameliorates the damage of hippocampal filamentous actin cytoskeleton but is not sufficient to cease epileptogenesis in pilocarpine induced epileptic mice. Epilepsy Res. 2019;154:26-33 pubmed publisher
    ..However, the number of ZNT3 positive particles in the molecular layer in the hippocampus of pilocarpine epileptic mice was not altered after ..
  5. Whitfield D, Francis P, Ballard C, Williams G. Associations between ZnT3, tau pathology, agitation, and delusions in dementia. Int J Geriatr Psychiatry. 2018;33:1146-1152 pubmed publisher
    ..between measurements of agitation, delusions, amyloid, tau and α-synuclein pathology, and synaptic proteins (ZnT3, PSD95, synaptophysin, and β-III-tubulin) across multiple brain regions in post-mortem tissue from a cohort of 130 ..
  6. Chacon J, Rosas L, Cuajungco M. ZnT3 expression levels are down-regulated in the brain of Mcoln1 knockout mice. Mol Brain. 2019;12:24 pubmed publisher
    ..Within certain subsets of glutamatergic neurons, ZnT3 (encoded by the Slc30a3 gene) facilitates the transport and storage of zinc in synaptic vesicles...
  7. Petersen A, Smidt K, Magnusson N, Moore F, Egefjord L, Rungby J. siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells. APMIS. 2011;119:93-102 pubmed publisher
    ..The aim of this study was to examine the effect of the zinc transporters ZnT3 and ZnT8 on insulin metabolism and apoptosis...
  8. Helgager J, Huang Y, McNamara J. Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo. J Comp Neurol. 2014;522:3885-99 pubmed publisher
    ..Unexpectedly, pY816 immunoreactivity was increased in axons but not synaptic boutons of mossy fibers in ZnT3 knockout mice that lack vesicular zinc...
  9. Fukue K, Itsumura N, Tsuji N, Nishino K, Nagao M, Narita H, et al. Evaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants. Sci Rep. 2018;8:14084 pubmed publisher
    ..Furthermore, we determined the role of the N-terminus by characterizing ZNT2 and ZNT3 domain-swapped and deletion mutants...

More Information

Publications63

  1. Flinn J, Bozzelli P, Adlard P, Railey A. Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels. Front Aging Neurosci. 2014;6:174 pubmed publisher
    ..Levels of the zinc transporter 3, ZnT3, were negatively correlated with soluble Aβ (p < 0.01)...
  2. Wu X, Gao L, Zhou K, Li X, Lin X, Wan D, et al. Deposition and transport of trace mineral elements were affected by stocking density in fattening pigs. J Trace Elem Med Biol. 2018;50:566-571 pubmed publisher
    ..05). mRNA expression of ATP7A, ATP7B, FRRS1, and SLC30A3 transporters was significantly upregulated in the liver of the medium-density group, and FRRS1 and SLC1A2 ..
  3. Adlard P, Parncutt J, Lal V, James S, Hare D, Doble P, et al. Metal chaperones prevent zinc-mediated cognitive decline. Neurobiol Dis. 2015;81:196-202 pubmed publisher
    Zinc transporter-3 (ZnT3) protein is responsible for loading zinc into presynaptic vesicles and consequently controls the availability of zinc at the glutamatergic synapse...
  4. Perez Rosello T, Anderson C, Ling C, Lippard S, Tzounopoulos T. Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission. Neurobiol Dis. 2015;81:14-9 pubmed publisher
    ..observed zinc-mediated inhibition in spontaneous firing is present in mice lacking the vesicular zinc transporter (ZnT3), indicating that non-vesicular zinc inhibits spontaneous firing...
  5. Seong E, Wainer B, Hughes E, Saunders T, Burmeister M, Faundez V. Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain. Mol Biol Cell. 2005;16:128-40 pubmed
    ..stores assessed by Timm's staining and the synaptic vesicle targeting of membrane proteins involved in zinc uptake (ZnT3 and ClC-3)...
  6. Tian T, Ni H, Sun B. Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals. Biol Trace Elem Res. 2015;167:251-8 pubmed publisher
    ..cognitive deficits, as well as if KD has any influence in the activity of zinc/lipid transporters such as zinc transporter 3 (ZnT-3), MT-3, ApoE, ApoJ (clusterin), and ACAT-1 activities in neonatal rats submitted to flurothyl-induced ..
  7. Salazar G. NADPH Oxidases and Mitochondria in Vascular Senescence. Int J Mol Sci. 2018;19: pubmed publisher
    ..the inflammatory gene nuclear factor &kappa;B (NF-&kappa;B), zinc, the zinc transporters (ZnTs) ZnT3 and ZnT10, and angiotensin II (Ang II) in mitochondrial function, and their role in telomere stability, which ..
  8. Ni H, Chen S, Li L, Jin M. Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin. Biol Trace Elem Res. 2019;187:100-106 pubmed publisher
    b>Zinc transporter 3 (ZnT3)-dependent "zincergic" vesicular zinc accounts for approximately 20% of the total zinc content of the mammalian telencephalon...
  9. da Rocha T, Korb C, Schuch J, Bamberg D, De Andrade F, Fiegenbaum M. SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults. Nutr Res. 2014;34:742-8 pubmed publisher
    ..The objective of this study was to determine the effects of solute carrier family 30 member 3 (SLC30A3) and 15-kd selenoprotein (SEP15) polymorphisms on zinc and selenium concentrations, respectively, in the serum...
  10. Tejeda Guzmán C, Rosas Arellano A, Kroll T, Webb S, Barajas Aceves M, Osorio B, et al. Biogenesis of zinc storage granules in Drosophila melanogaster. J Exp Biol. 2018;221: pubmed publisher
    ..of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C (ZnT2/ZnT3/ZnT8-like) transporters is required for zinc storage granule biogenesis...
  11. Suh S, Won S, Hamby A, Yoo B, Fan Y, Sheline C, et al. Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J Cereb Blood Flow Metab. 2009;29:1579-88 pubmed publisher
    ..Finally, the role of vesicular zinc on neurogenesis was further assessed in zinc transporter 3 (ZnT3) gene deleted mice...
  12. Ishihara Y, Fukuda T. Immunohistochemical investigation of the internal structure of the mouse subiculum. Neuroscience. 2016;337:242-266 pubmed publisher
    ..The border between the CA1 region and subiculum was determined by both cytoarchitecture and zinc transporter 3 (ZnT3)-immunoreactivity (IR), whereas the border between the subiculum and presubiculum (PreS) was partially ..
  13. Wojtkiewicz J, Rytel L, Makowska K, Gonkowski S. Co-localization of zinc transporter 3 (ZnT3) with sensory neuromediators and/or neuromodulators in the enteric nervous system of the porcine esophagus. Biometals. 2017;30:393-403 pubmed publisher
    b>Zinc transporter 3 (ZnT3) is one of the zinc transporters family. It is closely connected to the nervous system, where enables the transport of zinc ions from the cytoplasm to synaptic vesicles...
  14. Sopian N, Ajat M, Shafie N, Noor M, Ebrahimi M, Rajion M, et al. Does Short-Term Dietary Omega-3 Fatty Acid Supplementation Influence Brain Hippocampus Gene Expression of Zinc Transporter-3?. Int J Mol Sci. 2015;16:15800-10 pubmed publisher
    ..In addition, dietary omega-3 fatty acid deficiency increased the level of ZnT3 gene and subsequently reduced cognitive performance in mice...
  15. Yoo M, Kim T, Yoon Y, Koh J. Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation. Sci Rep. 2016;6:28548 pubmed publisher
    To investigate the role of synaptic zinc in the ASD pathogenesis, we examined zinc transporter 3 (ZnT3) null mice. At 4-5 weeks of age, male but not female ZnT3 null mice exhibited autistic-like behaviors...
  16. Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert H, et al. Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration. Proc Natl Acad Sci U S A. 2017;114:E209-E218 pubmed publisher
    ..accumulation in amacrine cell processes involves the Zn2+ transporter protein ZnT-3, and deletion of slc30a3, the gene encoding ZnT-3, promotes RGC survival and axon regeneration...
  17. Kho A, Kim O, Jeong J, Yu J, Kim H, Choi B, et al. Administration of placenta-derived mesenchymal stem cells counteracts a delayed anergic state following a transient induction of endogenous neurogenesis activity after global cerebral ischemia. Brain Res. 2018;1689:63-74 pubmed publisher
    ..The counts of BrdU-, Ki67- and DCX-positive cells and the intensity of zinc translocator 3 (ZnT3) were all significantly higher in the MSC-treated group than those in the control group at 3 weeks after GCI...
  18. Cai Y, Kirschke C, Huang L. SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the ?-cells. J Mol Histol. 2018;49:133-145 pubmed publisher
    ..differences in the expression of nine ZNT proteins in the human and mouse islets and ?-cells with exception of ZNT3, which was only detected in human ?-cells, but not in mouse ?-cells...
  19. Arru G, Caggiu E, Paulus K, Sechi G, Mameli G, Sechi L. Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease?. J Neuroimmunol. 2016;293:86-90 pubmed publisher
    ..The humoral response toward MAP3865c peptides, ZnT3 and ZnT10 was evaluated...
  20. Ben Mimouna S, Boughammoura S, Chemek M, Haouas Z, Banni M, Messaoudi I. Disruption of the zinc metabolism in rat fœtal brain after prenatal exposure to cadmium. Chem Biol Interact. 2018;286:88-95 pubmed publisher
    ..of that encoding the transporters involved in the output of the Zn into the extracellular medium (ZnT1 and ZnT3)...
  21. Rafalo A, Zadrozna M, Nowak B, Kotarska K, Wiatrowska K, Pochwat B, et al. The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2017;72:36-48 pubmed publisher
    ..Messenger RNA and proteins of ZnT1, ZnT3, ZnT4, ZnT5, ZnT6 and MT1/2 were measured in the prefrontal cortex (PFC) and hippocampus (Hp) of rats subjected to ..
  22. Kessels J, Wessels I, Haase H, Rink L, Uciechowski P. Influence of DNA-methylation on zinc homeostasis in myeloid cells: Regulation of zinc transporters and zinc binding proteins. J Trace Elem Med Biol. 2016;37:125-133 pubmed publisher
    ..The mRNA expression of ZIP14 was decreased, whereas zinc exporter ZnT3 mRNA was also significantly increased; which might be a cellular reaction to compensate elevated zinc levels...
  23. Ni H, Chen S, Li L, Jin M. Leptin treatment prevents long-term abnormalities in cognition, seizure threshold, hippocampal mossy fiber sprouting and ZnT3/CB-D28k expression in a rat developmental "twist" seizure model. Epilepsy Res. 2018;139:164-170 pubmed publisher
    ..threshold and hippocampal mossy fiber sprouting, as well if leptin had any influence on the expression of zinc transporter 3 (ZnT3) and calcium homeostasis-related CB-D28k in the hippocampus...
  24. Salazar G, Huang J, Feresin R, Zhao Y, Griendling K. Zinc regulates Nox1 expression through a NF-?B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells. Free Radic Biol Med. 2017;108:225-235 pubmed publisher
    ..protein expression, which was inhibited by chelation of zinc with TPEN and by overexpression of the zinc exporters ZnT3 and ZnT10...
  25. Choi B, Kim I, Kim J, Kho A, Lee S, Lee B, et al. Zinc transporter 3 (ZnT3) gene deletion reduces spinal cord white matter damage and motor deficits in a murine MOG-induced multiple sclerosis model. Neurobiol Dis. 2016;94:205-12 pubmed publisher
    The present study aimed to evaluate the role of zinc transporter 3 (ZnT3) on multiple sclerosis (MS) pathogenesis...
  26. Wojtkiewicz J, Makowska K, Bejer Olenska E, Gonkowski S. Zinc Transporter 3 (Znt3) as an Active Substance in the Enteric Nervous System of the Porcine Esophagus. J Mol Neurosci. 2017;61:315-324 pubmed publisher
    b>Zinc transporter 3 (ZnT3), a member of the SLC 30 zinc transporter family, is involved in the transport of zinc ions from the cytoplasm into synaptic vesicles or intracellular organelles...
  27. Medvedeva Y, Ji S, Yin H, Weiss J. Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria. J Neurosci. 2017;37:726-737 pubmed publisher
    ..However, using knock-out animals (of MT-III and vesicular Zn2+ transporter, ZnT3) and channel blockers revealed substantial differences in relevant Zn2+ sources, with critical ..
  28. Gonkowski S, Równiak M, Wojtkiewicz J. Zinc Transporter 3 (ZnT3) in the Enteric Nervous System of the Porcine Ileum in Physiological Conditions and during Experimental Inflammation. Int J Mol Sci. 2017;18: pubmed publisher
    b>Zinc transporter 3 (ZnT3) is a member of the solute-linked carrier 30 (SLC 30) zinc transporter family...
  29. Wang Y, Guan P, Yu X, Guo Y, Zhang Y, Wang Z, et al. COX-2 metabolic products, the prostaglandin I2 and F2?, mediate the effects of TNF-? and Zn2+ in stimulating the phosphorylation of Tau. Oncotarget. 2017;8:99296-99311 pubmed publisher
    ..high level of Zn2+ upregulates the expression of COX-2 via stimulating the activity of TNF-? in a zinc transporter 3 (ZnT3)-dependent mechanism...
  30. Patrick Wu H, Dyck R. Signaling by Synaptic Zinc is Required for Whisker-Mediated, Fine Texture Discrimination. Neuroscience. 2018;369:242-247 pubmed publisher
    ..b>Zinc transporter 3 (ZnT3) knockout (KO) mice lack synaptic zinc and provide us with a good model to examine the contribution of ..
  31. Perez Becerril C, Morris A, Mortimer A, McKenna P, de Belleroche J. Allelic variants in the zinc transporter-3 gene, SLC30A3, a candidate gene identified from gene expression studies, show gender-specific association with schizophrenia. Eur Psychiatry. 2014;29:172-8 pubmed publisher
    ..One of these genes validated in both cohorts, SLC30A3, which encodes the Zinc Transporter 3 (ZNT3), is localised to synaptic vesicles in glutamate synapses and known ..
  32. Whitfield D, Vallortigara J, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, et al. Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment. Neurobiol Aging. 2014;35:2836-2844 pubmed publisher
    The loss of zinc transporter 3 (ZnT3) has been implicated in age-related cognitive decline in mice, and the protein has been associated with plaques...
  33. Whitfield D, Vallortigara J, Alghamdi A, Hortobagyi T, Ballard C, Thomas A, et al. Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia. Am J Geriatr Psychiatry. 2015;23:141-8 pubmed publisher
    ..We investigated the relationship between synaptic zinc regulation (for which zinc transporter 3 [ZnT3] is responsible) and depression in a large clinicopathologic study...
  34. Hardt S, Heidler J, Albuquerque B, Valek L, Altmann C, Wilken Schmitz A, et al. Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2727-2745 pubmed publisher
    ..deficiency was associated with a deficiency of nuclear and synaptic zinc transporters (ZnT9/Slc30a9; ZnT3/Slc30a3) with low plasma zinc...
  35. Rafalo Ulinska A, Piotrowska J, Kryczyk A, Opoka W, Sowa Kucma M, Misztak P, et al. Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims. J Psychiatr Res. 2016;83:220-229 pubmed publisher
    ..Protein levels of ZnT1, ZnT3, ZnT4, ZnT5 and ZnT6 were measured in postmortem brain tissue from two different cohorts...
  36. Thackray S, McAllister B, Dyck R. Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice. Behav Brain Res. 2017;321:36-49 pubmed publisher
    ..In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function...
  37. Lee B, Choi B, Hong D, Kim J, Lee S, Kho A, et al. The cancer chemotherapeutic agent paclitaxel (Taxol) reduces hippocampal neurogenesis via down-regulation of vesicular zinc. Sci Rep. 2017;7:11667 pubmed publisher
    ..We found that vesicular zinc levels and expression of zinc transporter 3 (ZnT3) were reduced in Px-treated mice, compared to vehicle-treated mice...
  38. Zhang L, Wang X, Stoltenberg M, Danscher G, Huang L, Wang Z. Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. Brain Res Bull. 2008;77:55-60 pubmed publisher
    ..Moreover, we found an abundant expression of ZNT3 and autometallographic grains in the amyloid angiopathic vessels...
  39. Choi B, Hong D, Suh S. ZnT3 Gene Deletion Reduces Colchicine-Induced Dentate Granule Cell Degeneration. Int J Mol Sci. 2017;18: pubmed publisher
    ..Zinc is concentrated in the synaptic vesicles via zinc transporter 3 (ZnT3), which facilitates zinc transport from the cytosol into the synaptic vesicles...
  40. Seve M, Chimienti F, Devergnas S, Favier A. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. BMC Genomics. 2004;5:32 pubmed
    ..The method presented herein provides a useful tool to complete gene families from sequencing programs and to produce preliminary expression data to select the proper biological samples for laboratory experimentation. ..
  41. Overbeck S, Uciechowski P, Ackland M, Ford D, Rink L. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol. 2008;83:368-80 pubmed
    ..These data provide insight into the regulation of intracellular zinc homeostasis in cells of the immune system and may explain the variable effects of zinc deficiency on different leukocyte subsets. ..
  42. Fujihara J, Yasuda T, Kimura Kataoka K, Takinami Y, Nagao M, Takeshita H. Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans. Leg Med (Tokyo). 2018;30:28-33 pubmed publisher
    ..Among the 20 SNPs examined, 3 SNPs (SLC30A3 rs11126936, SLC39A8 rs233804, and SLC39A14 rs4872479) were significantly associated with blood zinc concentration...
  43. Perez Becerril C, Morris A, Mortimer A, McKenna P, de Belleroche J. Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples. Psychiatry Res. 2016;246:335-340 pubmed publisher
    Previously, we found a significant gender-specific association of schizophrenia, in a UK case/control study, with SLC30A3, a candidate that is consistently down-regulated in schizophrenia in two independent cohorts...
  44. Kurita H, Okuda R, Yokoo K, Inden M, Hozumi I. Protective roles of SLC30A3 against endoplasmic reticulum stress via ERK1/2 activation. Biochem Biophys Res Commun. 2016;479:853-859 pubmed publisher
    ..The previous studies have shown that SLC30A3 level is decreased in prefrontal cortex of AD patients...
  45. Smidt K, Larsen A, Brønden A, Sørensen K, Nielsen J, Praetorius J, et al. The zinc transporter ZNT3 co-localizes with insulin in INS-1E pancreatic beta cells and influences cell survival, insulin secretion capacity, and ZNT8 expression. Biometals. 2016;29:287-98 pubmed publisher
    ..into insulin granules and is critical for a correct insulin crystallization and storage in the granules whereas ZNT3 knockout negatively affects beta cell function and survival...
  46. Hildebrand M, Phillips A, Mullen S, Adlard P, Hardies K, Damiano J, et al. Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015;5:17816 pubmed publisher
    ..Synaptic Zn(2+) is co-released with glutamate and modulates neuronal excitability. SLC30A3 encodes the zinc transporter 3 (ZNT3), which is primarily responsible for moving Zn(2+) into synaptic vesicles...
  47. Mimouna S, Chemek M, Boughammoura S, Banni M, Messaoudi I. Early-Life Exposure to Cadmium Triggers Distinct Zn-Dependent Protein Expression Patterns and Impairs Brain Development. Biol Trace Elem Res. 2018;184:409-421 pubmed publisher
    ..Zrt-,Irt-related protein 6 (ZIP6) gene and a significant downregulation of the expression of the Zn transporter 3 (ZnT3) and brain-derived neurotrophic factor (BDNF) genes in the brain...
  48. Choi B, Jung J, Suh S. The Emerging Role of Zinc in the Pathogenesis of Multiple Sclerosis. Int J Mol Sci. 2017;18: pubmed publisher
    ..To confirm our previous study, we employed zinc transporter 3 (ZnT3) knockout mice to test whether vesicular zinc depletion shows protective effects on multiple ..
  49. Golan Y, Berman B, Assaraf Y. Heterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementation. J Biol Chem. 2015;290:9050-63 pubmed publisher
    ..Specifically, unlike the plasma membrane (PM) localization of ZnT1 homodimers, ZnT1-ZnT3 heterodimers localized at intracellular vesicles...
  50. Iguchi K, Otsuka T, Usui S, Ishii K, Onishi T, Sugimura Y, et al. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. J Androl. 2004;25:154-61 pubmed
    ..AIDL cells exhibited a lower expression of zinc transporter 1 (ZnT1) and higher expression of ZnT3 than LNCaP cells...
  51. McAllister B, Dyck R. Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function. Neurosci Biobehav Rev. 2017;80:329-350 pubmed publisher
    b>Zinc transporter 3 (ZnT3) is the sole mechanism responsible for concentrating zinc ions within synaptic vesicles in a subset of the brain's glutamatergic neurons...
  52. Zhao Y, Feresin R, Falcon Perez J, Salazar G. Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity. Traffic. 2016;17:267-88 pubmed publisher
    ..We reported that formation of tyrosine dimers is required for ZnT3 (zinc transporter 3) zinc transport activity and targeting to synaptic-like microvesicles (SLMVs) in PC12 cells and the ..
  53. Kaneko M, Noguchi T, Ikegami S, Sakurai T, Kakita A, Toyoshima Y, et al. Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis. J Neurosci Res. 2015;93:370-9 pubmed publisher
    ..b>ZnT3 and ZnT6 protein levels were significantly diminished in the spinal cords of sporadic ALS patients compared with ..
  54. Salazar G, Falcon Perez J, Harrison R, Faundez V. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. PLoS ONE. 2009;4:e5896 pubmed publisher
    ..Here, we described a novel oligomerization mechanism affecting solute carrier family 30 member 3/zinc transporter 3 (SLC30A3/ZnT3). Oligomerization was mediated by intermolecular covalent dityrosine bonds...