SLC30A10

Summary

Gene Symbol: SLC30A10
Description: solute carrier family 30, member 10
Alias: HMDPC, ZNT10, ZNT8, ZRC1, ZnT-10, zinc transporter 10, zinc transporter 8
Species: human

Top Publications

  1. doi Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: impli
    J De Grijse
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Diabetologia 53:517-24. 2010
  2. pmc Saccharomyces cerevisiae vacuole in zinc storage and intracellular zinc distribution
    Claudia Simm
    Department of Nutritional Sciences, 1415 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    Eukaryot Cell 6:1166-77. 2007
  3. doi Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes
    E Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Diabetologia 51:2299-302. 2008
  4. doi Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    P Achenbach
    Diabetes Research Institute of Forschergruppe Diabetes e V, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Diabetologia 52:1881-8. 2009
  5. ncbi Emergence of anti-islet autoantibodies in Japanese patients with type 1 diabetes
    Ichiro Horie
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Endocr J 57:623-8. 2010
  6. doi Three DNA methylation epigenotypes in human colorectal cancer
    Koichi Yagi
    Genome Science Division, Department of Gastrointestinal Surgery, Research Center for Advanced Science and Technology, Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 16:21-33. 2010
  7. doi Clinical applications of diabetes antibody testing
    Polly J Bingley
    Department of Clinical Science at North Bristol, Medical School Unit, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 95:25-33. 2010
  8. pmc Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae
    Wei Qiao
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Microbiol 72:320-34. 2009
  9. doi ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset
    Fariba Vaziri-Sani
    Department of Clinical Sciences, University Hospital MAS, Lund University, Malmo, Sweden
    Autoimmunity 43:598-606. 2010
  10. doi Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice
    Motoyuki Tamaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    Islets 1:124-8. 2009

Research Grants

Scientific Experts

Detail Information

Publications126 found, 100 shown here

  1. doi Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: impli
    J De Grijse
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Diabetologia 53:517-24. 2010
    ..for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-..
  2. pmc Saccharomyces cerevisiae vacuole in zinc storage and intracellular zinc distribution
    Claudia Simm
    Department of Nutritional Sciences, 1415 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    Eukaryot Cell 6:1166-77. 2007
    ..While the Zrc1 and Cot1 zinc transporters are essential for zinc uptake into the vacuole under steady-state growth conditions, ..
  3. doi Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes
    E Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Diabetologia 51:2299-302. 2008
    We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein.
  4. doi Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    P Achenbach
    Diabetes Research Institute of Forschergruppe Diabetes e V, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Diabetologia 52:1881-8. 2009
    Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk.
  5. ncbi Emergence of anti-islet autoantibodies in Japanese patients with type 1 diabetes
    Ichiro Horie
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Endocr J 57:623-8. 2010
    ..With stored sera we retrospectively followed her anti-islet autoantibodies. GAD65Ab, zinc transporter 8 autoantibodies (ZnT8Ab) and insulin autoantibodies (IAA) were found to be positive at age 25...
  6. doi Three DNA methylation epigenotypes in human colorectal cancer
    Koichi Yagi
    Genome Science Division, Department of Gastrointestinal Surgery, Research Center for Advanced Science and Technology, Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 16:21-33. 2010
    ..Our aim is to clarify DNA methylation epigenotypes of colorectal cancer more comprehensively...
  7. doi Clinical applications of diabetes antibody testing
    Polly J Bingley
    Department of Clinical Science at North Bristol, Medical School Unit, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 95:25-33. 2010
    ..Autoantibody assays are increasingly available to clinicians. This article reviews the prognostic significance of autoantibodies and considers the utility of diabetes antibody testing in routine clinical practice...
  8. pmc Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae
    Wei Qiao
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Microbiol 72:320-34. 2009
    ..We also assessed which zinc transporters are responsible for supplying zinc to Pho8. We found that the Zrc1 and Cot1 vacuolar zinc transporters play the major role while the Msc2/Zrg17 zinc transporter complex active in the ..
  9. doi ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset
    Fariba Vaziri-Sani
    Department of Clinical Sciences, University Hospital MAS, Lund University, Malmo, Sweden
    Autoimmunity 43:598-606. 2010
    Autoantibodies to the islet-specific zinc transporter isoform 8 (ZnT8) are detected in the majority of type 1 diabetes patients prior to and at clinical diagnosis. The presence of ZnT8Ab after diagnosis has not been investigated...
  10. doi Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice
    Motoyuki Tamaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    Islets 1:124-8. 2009
    b>Zinc transporter 8 (ZnT8) has been identified as a β-cell-specific Zinc transporter expressed in insulin-secretory granules...
  11. pmc Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
    K Lemaire
    Gene Expression Unit, Department Molecular Cell Biology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:14872-7. 2009
    ..In this study we assessed the role of the zinc transporter ZnT8 using ZnT8-knockout (ZnT8(-/-)) mice...
  12. pmc Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
    Yi Fu
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 4:e5679. 2009
    The SLC30A8 gene codes for a pancreatic beta-cell-expressed zinc transporter, ZnT8. A polymorphism in the SLC30A8 gene is associated with susceptibility to type 2 diabetes, although the molecular mechanism through which this phenotype is ..
  13. doi Think zinc: New roles for zinc in the control of insulin secretion
    Guy A Rutter
    Department of Cell Biology, Imperial College London, UK
    Islets 2:49-50. 2010
    Genome wide association studies have identified the islet-restricted zinc transporter ZnT8 (SLC30A8) as a likely player in the control of insulin secretion and the risk of developing type 2 diabetes...
  14. pmc The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese
    Lin Yang
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China
    Diabetes Metab Res Rev 26:579-84. 2010
    Zinc transporter-8 (ZnT8) was recently identified as a novel autoantigen in human type 1 diabetes (T1D)...
  15. ncbi Novel antigens in type 1 diabetes: the importance of ZnT8
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, 1775 North Ursula Court, Aurora, CO 80045, USA
    Curr Diab Rep 9:105-12. 2009
    ..b>ZnT8 was recently defined as a candidate autoantigen based on a -bioinformatics analysis focused on discovery of beta-..
  16. doi Identification of a major humoral epitope in Slc30A8 (ZnT8)
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:252-5. 2008
    The human zinc transporter Slc30A8 (ZnT8) is a major target of humoral autoimmunity in human type 1A diabetes. However, despite extensive conservation, the majority of human autoimmune sera fail to recognize the murine ortholog...
  17. doi SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:256-9. 2008
    ..The highest ranking candidate was Slc30A8 (zinc transporter 8; ZnT8), which was screened by radioimmunoprecipitation assays against new-onset T1D and prediabetic sera...
  18. ncbi The Arabidopsis metal tolerance protein AtMTP3 maintains metal homeostasis by mediating Zn exclusion from the shoot under Fe deficiency and Zn oversupply
    Stéphanie Arrivault
    Max Planck Institute of Molecular Plant Physiology, D 14424 Potsdam, Germany
    Plant J 46:861-79. 2006
    ..Heterologous expression of a previously uncharacterized Arabidopsis thaliana metal tolerance protein, MTP3, in the zrc1 cot1 mutant of budding yeast restores tolerance to, and cellular accumulation of, zinc and cobalt...
  19. ncbi Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity
    L Li
    Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 273:22181-7. 1998
    ..Multiple copies of transition metal transporter resistance genes, such as COT1 or ZRC1, do not reduce the metal sensitivity of fet3 mutations...
  20. pmc AtHMA3, a P1B-ATPase allowing Cd/Zn/Co/Pb vacuolar storage in Arabidopsis
    Melanie Morel
    l Energie Atomique, DSV, IBEB, Lab Echanges Membran and Signalisation, Saint Paul lez Durance F 13108, France
    Plant Physiol 149:894-904. 2009
    ..complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1. In this study, we demonstrate that AtHMA3 in planta is located in the vacuolar membrane, with a high expression ..
  21. pmc A combined zinc/cadmium sensor and zinc/cadmium export regulator in a heavy metal pump
    Lone Baekgaard
    Department of Plant Biology and Biotechnology, Centre for Membrane Pumps in Cells and Disease, PUMPKIN, Danish National Research Foundation, University of Copenhagen, Thorvaldsensvej 40, DK 1871 Frederiksberg C, Denmark
    J Biol Chem 285:31243-52. 2010
    ..When AtHMA4 is expressed in a Zn(2+)-sensitive zrc1 cot1 yeast strain, sequential removal of the histidine stretch and the cysteine pairs confers a gradual increase in ..
  22. doi New antigenic targets in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 15:315-20. 2008
    ..We examine the hypothesis that the cell specificity and cellular localization of this granule membrane protein are significant factors in its contribution to the pathogenesis of these diseases...
  23. ncbi Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance
    Elizabeth Bilsland
    Department of Cell and Molecular Biology, Lundberg Laboratory, Goteborg University, PO Box 462, SE 405 30 Goteborg, Sweden
    Mol Microbiol 53:1743-56. 2004
    ..We identify the transcription factor Yap2 as a putative target for Rck1, and the Zn2+ transporter Zrc1 as a target for Rck2...
  24. ncbi Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock
    Colin W MacDiarmid
    Departments of Nutritional Sciences and Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 278:15065-72. 2003
    ..For this reason, intracellular zinc levels are tightly controlled. In the yeast Saccharomyces cerevisiae, the Zrc1 and Cot1 proteins have been implicated in the storage and detoxification of excess zinc in the vacuole...
  25. doi Role of zinc in the regulation of autophagy during ethanol exposure in human hepatoma cells
    J P Liuzzi
    Department of Dietetics and Nutrition, Florida International University, Miami, USA
    Biol Trace Elem Res 156:350-6. 2013
    ..In addition, labile zinc and mRNA expression of metallothionein and the zinc transporters SLC39A8, SLC39A14, and SLC30A10 were evaluated in cells exposed to ethanol and the autophagy inhibitor 3-methyladenine...
  26. ncbi Distribution of zinc and zinc transporters in the mouse ovarian follicles and corpus luteum
    Man Li Zhong
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, and Department of Pathophysiology, China Medical University, Shenyang, P R China
    Histol Histopathol 28:1517-27. 2013
    ..ZnT1-9 mRNA was variously expressed, whereas ZnT10 mRNA was almost undetectable in the ovary...
  27. pmc Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 36:2266-70. 2013
    ..We evaluated a novel electrochemiluminescent assay for insulin/proinsulin autoantibodies (ECL-IAA) as a new marker of the onset of islet autoimmunity and as a predictor of type 1 diabetes...
  28. pmc iPSC-derived β cells model diabetes due to glucokinase deficiency
    Haiqing Hua
    The New York Stem Cell Foundation Laboratory, New York, New York, USA
    J Clin Invest 123:3146-53. 2013
    ..comparable to that of controls and expressed markers of mature β cells, including urocortin-3 and zinc transporter 8, upon transplantation into mice...
  29. ncbi Biochemical properties of vacuolar zinc transport systems of Saccharomyces cerevisiae
    Colin W MacDiarmid
    Departments of Nutritional Sciences and Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 277:39187-94. 2002
    ..One system we identified was dependent on the ZRC1 gene, which encodes a member of the cation diffusion facilitator family of metal transporters...
  30. doi The role of autoantibodies to zinc transporter 8 in prediction of type 1 diabetes in relatives: lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) cohort
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK
    J Clin Endocrinol Metab 97:632-7. 2012
    Antibodies to islet autoantigens are detectable many years before clinical onset of type 1 diabetes and can be used to identify individuals at increased risk of diabetes. Zinc transporter 8 is a recently identified islet autoantigen.
  31. doi Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes
    Marie Louise M Andersen
    Department of Paediatrics, Herlev University Hospital, Herlev, Denmark
    Pediatr Diabetes 13:454-62. 2012
    The zinc transporter 8 (ZnT8) was recently identified as a common autoantigen in type 1 diabetes (T1D) and inclusion of ZnT8 autoantibodies (ZnT8Ab) was found to increase the diagnostic specificity of T1D.
  32. pmc Novel autoantigens in type 1 diabetes
    Shuhong Han
    Department of Medicine, University of Florida College of Medicine Gainesville, Florida 32610, USA
    Am J Transl Res 5:379-92. 2013
    ..Since many excellent reviews have covered the previously identified T1DM-associated AAgs exhaustedly, here we only focus on several recently discovered T1DM-AAgs (PDX1, ZnT8, CHGA, and IAAP).
  33. pmc Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man
    Karin Tuschl
    Clinical and Molecular Genetics Unit, University College London Institute of Child Health, UK
    Am J Hum Genet 90:457-66. 2012
    ..Whole-genome mapping of two consanguineous families identified SLC30A10 as the affected gene in this inherited type of hypermanganesemia...
  34. pmc Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
    Joshua C Randall
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 9:e1003500. 2013
    ..significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were ..
  35. doi Zinc transporter 8 autoantibody (ZnT8A) could help differentiate latent autoimmune diabetes in adults (LADA) from phenotypic type 2 diabetes mellitus
    Gan Huang
    Diabetes Center, Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China
    Diabetes Metab Res Rev 29:363-8. 2013
    ..We investigated the distribution and clinical features of ZnT8A positive latent autoimmune diabetes in adult (LADA) patients to explore the potential diagnostic application...
  36. pmc Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations
    Margaret R Dewitt
    Vanderbilt Center for Molecular Toxicology, Department of Pediatrics, Nashville, TN 37232 8552, USA
    Biochem Biophys Res Commun 432:1-4. 2013
    ..A recently discovered mutation in SLC30A10 identified its gene product as putatively involved in Mn efflux...
  37. doi Identification of novel HLA-A 0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8
    Shufa Li
    Endocrinology Division, Linyi People s Hospital, Linyi 276000, China
    Vaccine 31:1610-5. 2013
    ..b>Zinc Transporter 8 (ZnT8) has emerged in recent years as a target of disease-associated autoreactive T cells in human T1D...
  38. pmc HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients
    Eric Mbunwe
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Diabetes 62:1345-50. 2013
    ..002). In conclusion, HLA-A*24 independently predicts rapid progression to T1D in Ab(+) relatives and complements IA-2A, ZnT8A, and HLA-DQ2/DQ8 for identifying participants in immunointervention trials...
  39. pmc Extrapancreatic autoantibody profiles in type I diabetes
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, and National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e45216. 2012
    ..heterogeneity in autoantibody responses against islet cell autoantigens including two polymorphic variants of ZnT8. A subset of T1D subjects exhibited autoantibodies against several organ-specific targets including gastric ATPase (..
  40. doi Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus
    J Dereke
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabet Med 29:e436-9. 2012
    ..A recently identified autoantigen in Type 1 diabetes is zinc transporter 8. Some reports suggest that the frequency of zinc transporter 8 antibodies is as high as glutamic acid ..
  41. pmc Identification of the human zinc transcriptional regulatory element (ZTRE): a palindromic protein-binding DNA sequence responsible for zinc-induced transcriptional repression
    Lisa J Coneyworth
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4NN, United Kingdom
    J Biol Chem 287:36567-81. 2012
    ..search) the CBWD genes and (through targeted analysis) in multiple members of the SLC30 family, including SLC30A10, which is repressed by zinc...
  42. pmc Zinc transporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis study
    Ahmed J Delli
    Department of Clinical Sciences, Diabetes and Celiac Diseases, Lund University, Malmo, Sweden
    Diabetes 61:2556-64. 2012
    We examined whether zinc transporter 8 autoantibodies (ZnT8A; arginine ZnT8-RA, tryptophan ZnT8-WA, and glutamine ZnT8-QA variants) differed between immigrant and Swedish patients due to different polymorphisms of SLC30A8, HLA-DQ, or both...
  43. doi Widespread expression of zinc transporter ZnT (SLC30) family members in mouse endocrine cells
    Man Li Zhong
    Department of Pathophysiology, China Medical University, Shenyang 110001, People s Republic of China
    Histochem Cell Biol 138:605-16. 2012
    ..In general, ZnT1-10 mRNA was expressed to various degrees in the detected endocrine organs, with no detectable ZnT10 mRNA in the pancreas...
  44. doi Dietary fiber intake increases the risk of zinc deficiency in healthy and diabetic women
    Meika Foster
    Discipline of Nutrition and Metabolism, School of Molecular Bioscience G08, University of Sydney, Sydney, NSW, 2006, Australia
    Biol Trace Elem Res 149:135-42. 2012
    ..Plasma zinc concentrations and zinc transporter (ZnT1, ZnT8, and Zip1) gene expression in mononuclear cells were measured...
  45. doi Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc
    Judith Jansen
    Institute of Immunology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    J Nutr Biochem 23:1458-66. 2012
    ..and 75 nondiabetic sex-/age-matched control subjects in order to analyze differences concerning human zinc transporter 8 (hZnT-8) expression, single nucleotide polymorphisms (SNPs) in the genes of hZnT-8 as well as ..
  46. doi Autoantibodies to CCL3 are of low sensitivity and specificity for the diagnosis of type 1 diabetes
    Gan Huang
    Diabetes Center, 2nd Xiangya Hospital, Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan, China
    Acta Diabetol 49:395-9. 2012
    ..9633 and 0.4095 vs. 0.0873, P = 0.012 and P = 0.034, respectively). We conclude that autoantibodies to CCL3 are of low sensitivity and specificity for T1D and cannot be used in the diagnosis of T1D...
  47. pmc The genetics of dystonia: new twists in an old tale
    Gavin Charlesworth
    Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Brain 136:2017-37. 2013
    ..and GNAL), PRRT2 has been identified as the cause of paroxysmal kinesigenic dystonia and other genes, such as SLC30A10 and ATP1A3, have been linked to more complicated forms of dystonia or new phenotypes...
  48. doi Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands
    C Murgia
    INRAN, National Research Institute on Food and Nutrition, Via Ardeatina 546, Roma 00178, Italy
    Nutr Metab Cardiovasc Dis 19:431-9. 2009
    ..b>ZnT8 is a member of the SLC30A family of zinc transporters whose overexpression in cultured pancreatic beta cells leads ..
  49. ncbi The Zrc1 is involved in zinc transport system between vacuole and cytosol in Saccharomyces cerevisiae
    S Miyabe
    Research Institute for Food Science, Kyoto University, Uji, Kyoto, 611 0011, Japan
    Biochem Biophys Res Commun 282:79-83. 2001
    The ZRC1 gene encodes a multicopy suppressor of zinc toxicity in Saccharomyces cerevisiae; however, previously we found that the expression of ZRC1 was induced when the intracellular zinc level was decreased...
  50. pmc ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes
    Emmanuelle Enée
    INSERM, Unité 1013, Paris, France
    Diabetes 61:1779-84. 2012
    ..1) to develop a CD8(+) T-cell interferon-γ ELISpot assay for pediatric patients and 2) to determine whether zinc transporter 8 (ZnT8), a recently described target of autoantibodies in a majority of patients, is also recognized by ..
  51. pmc Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells
    Nikolay Patrushev
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 7:e33211. 2012
    ..II-induced senescence is a zinc-dependent pathway mediated by the downregulation of the zinc transporters ZnT3 and ZnT10, which work to reduce cytosolic zinc...
  52. pmc Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado, USA
    Diabetes Care 35:1213-8. 2012
    ....
  53. pmc Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients
    M Scotto
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Diabetologia 55:2026-31. 2012
    Anti-zinc transporter (ZnT)8 autoantibodies are commonly detected in type 1 diabetic patients. We hypothesised that ZnT8 is also recognised by CD8(+) T cells and aimed to identify HLA-A2 (A*02:01)-restricted epitope targets.
  54. pmc Genetic variants on chromosome 1q41 influence ocular axial length and high myopia
    Qiao Fan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
    PLoS Genet 8:e1002753. 2012
    ..84, P(meta) =4.38 × 10(-7)) in 1,118 highly myopic cases and 5,433 controls. ZC3H11B and two neighboring genes SLC30A10 and LYPLAL1 were expressed in the human neural retina, retinal pigment epithelium, and sclera...
  55. doi SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population
    J Xu
    Endocrinology Department of Southwest Hospital, Third Military Medical University, Chongqing, China
    Genet Mol Res 11:1592-8. 2012
    ..The A-C-A haplotype appears to be a risk factor and the A-C-G haplotype may be a protective factor against type 2 diabetes in Chinese Han...
  56. pmc Etiopathogenesis of insulin autoimmunity
    Norio Kanatsuna
    Department of Clinical Sciences, Skåne University Hospital SUS, Lund University, CRC Ing 72 Building 91 10, 205 02 Malmo, Sweden
    Anat Res Int 2012:457546. 2012
    ..In contrast to autoantibodies against other islet autoantigens such as GAD65, IA-2, and ZnT8 transporters, it has not been possible yet to standardize the insulin autoantibody test...
  57. doi The effect of type 2 diabetes risk loci on insulin requirements in type 1 diabetes
    Mandana Moosavi
    Departments of Paediatrics and Human Genetics, McGill University Health Centre, Montreal, Que, Canada
    Horm Res Paediatr 77:305-8. 2012
    ..To analyze the correlation between insulin requirements of type 1 diabetic (T1D) patients and genotype at type 2 diabetes (T2D) risk loci, obtained in our genome-wide association study...
  58. doi Regulation and functional effects of ZNT8 in human pancreatic islets
    Bruno Lefebvre
    Univ Lille Nord de France, F 59000 Lille, France
    J Endocrinol 214:225-32. 2012
    ..Both zinc depletion and lipotoxicity (but not glucotoxicity) downregulated ZNT8 (SLC30A8) expression and altered the glucose-stimulated insulin secretion index (GSIS)...
  59. doi Regulator of complement activation (RCA) group 2 gene cluster in zebrafish: identification, expression, and evolution
    Jie Wu
    Laboratory for Evolution and Development, Institute of Evolution and Marine Biodiversity, Qingdao 266003, China
    Funct Integr Genomics 12:367-77. 2012
    ..Here we identified two closely linked RCA group 2 genes in zebrafish, ZRC1 and ZRC2, which had all the features characteristic of known RCA group 2 genes...
  60. pmc Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease
    Marialuisa Quadri
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Am J Hum Genet 90:467-77. 2012
    ..We localized the genetic defect by homozygosity mapping and then identified two different homozygous frameshift SLC30A10 mutations, segregating with disease...
  61. pmc Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8
    A B Hardy
    Department of Physiology, University of Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 302:E1084-96. 2012
    Genomewide association studies have linked a polymorphism in the zinc transporter 8 (Znt8) gene to higher risk of developing type 2 diabetes...
  62. pmc Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 61:683-6. 2012
    ..Autoantibodies to insulin (IAA), GAD (GADA), islet antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A) were measured by radioimmunoassay in sera collected from children and young adults with newly ..
  63. doi Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays
    Xiangmei Wu
    Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Autoimmunity 45:176-85. 2012
    ..Zinc transporter-8 (ZnT8) has emerged in recent years as a novel, major, human autoantigen...
  64. doi Detection and characterization of ZnT8 autoantibodies could help to screen latent autoimmune diabetes in adult-onset patients with type 2 phenotype
    Aldana Trabucchi
    Chair of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires UBA, Buenos Aires, Argentina
    Autoimmunity 45:137-42. 2012
    Autoantibodies to zinc transporter 8 (ZnT8A) constitute an additional marker of autoimmune diabetes, complementing those already used in diagnosis support. ZnT8A could also be found in latent autoimmune diabetes of adults (LADA)...
  65. doi Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, and Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Diabetes Metab Res Rev 27:895-8. 2011
    The aim of this study was to determine the prevalence and role of autoantibodies to zinc transporter 8 (ZnT8A) in three forms (fulminant, acute-onset, and slow-onset) of Japanese patients with type 1 diabetes.
  66. pmc TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
    Gabriela Da Silva Xavier
    Section of Cell Biology, Division of Medicine, Faculty of Medicine, Imperial College, London, UK
    Diabetes 58:894-905. 2009
    ..However, the mechanisms by which TCF7L2 affect insulin secretion are still unclear. We define the effects of TCF7L2 expression level on mature beta-cell function and suggest a potential mechanism for its actions...
  67. pmc A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity
    Huilan Lin
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 283:33865-73. 2008
    ..We identified a mutation (N44I) in the vacuolar zinc transporter ZRC1 that changed the substrate specificity of the transporter from zinc to iron...
  68. pmc COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae
    D S Conklin
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Mol Cell Biol 12:3678-88. 1992
    ..The COT1 protein shares 60% identity with the ZRC1 gene product, which confers resistance to zinc and cadmium ions...
  69. pmc Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes
    Jeesuk Yu
    University of Colorado Health Sciences Center, Aurora, Colorado, USA
    J Clin Endocrinol Metab 94:504-10. 2009
    ..There is controversy as to whether type 2 diabetes genetic susceptibility contributes to type 1 diabetes, and it is not known what proportion of islet autoantibody-negative new onset subjects have type 2 diabetes risk alleles...
  70. pmc Tracing the Pathogenesis of Type 1 Diabetes: A Report on the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD)
    Liang Hao Guo
    Diabetes Research Institute, Munich, Germany
    Rev Diabet Stud 5:171-4. 2008
    ..This report highlights some of the recent studies on diabetes biomarkers, with a particular focus on zinc transporter ZnT8, presented at the EASD meeting in September 2008 in Rome, Italy.
  71. pmc Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity
    Miki Kawachi
    Laboratory of Cell Dynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Biol Chem 283:8374-83. 2008
    ..expression system in the yeast Saccharomyces cerevisiae, which lacked genes for vacuolar membrane zinc transporters ZRC1 and COT1. The yeast mutant expressing AtMTP1 heterologously was tolerant to 10 mm ZnCl(2)...
  72. ncbi Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae
    A Kamizono
    Biosciences Laboratory, Mitsubishi Kasei Corporation, Yokohama, Japan
    Mol Gen Genet 219:161-7. 1989
    ..Therefore, we termed it the ZRC1 (zinc resistance conferring) gene...
  73. ncbi Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae
    D S Conklin
    Laboratory of Molecular Biology, University of Wisconsin Madison 53706
    Mol Gen Genet 244:303-11. 1994
    The COT1 and ZRC1 genes of Saccharomyces cerevisiae are structurally related dosage-dependent suppressors of metal toxicity...
  74. ncbi Expression of ZRC1 coding for suppressor of zinc toxicity is induced by zinc-starvation stress in Zap1-dependent fashion in Saccharomyces cerevisiae
    S Miyabe
    Research Institute for Food Science, Kyoto, 611 0011, Japan
    Biochem Biophys Res Commun 276:879-84. 2000
    The ZRC1 gene was cloned as a multicopy suppressor of zinc toxicity in Saccharomyces cerevisiae. Zrc1 belongs to CDF (cation diffusion facilitator) family...
  75. ncbi Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells
    Taiho Kambe
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 277:19049-55. 2002
    ..We have identified a novel mammalian zinc transporter, zinc transporter 5 (ZnT-5), by virtue of its similarity to ZRC1, a zinc transporter of Saccharomyces cerevisiae, a member of the cation diffusion facilitator family...
  76. pmc In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression
    Michel Seve
    DRFMC SCIB LAN, CEA Grenoble, Grenoble, France
    BMC Genomics 5:32. 2004
    ..ZnT proteins are members of the cation diffusion facilitator (CDF) family of metal ion transporters...
  77. pmc Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function
    Charissa D Ellis
    Department of Biochemistry, University of Missouri, Columbia 65211, USA
    J Cell Biol 166:325-35. 2004
    ..We also show that the vacuolar CDF proteins Zrc1 and Cot1 are other pathways of ER zinc acquisition...
  78. ncbi In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
    Fabrice Chimienti
    DRFMC SCIB LAN, UMR E3 CEA UJF, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    J Cell Sci 119:4199-206. 2006
    ..e. >10 mM glucose. Altogether, these data strongly suggest that the zinc transporter ZnT-8 is a key protein for both zinc accumulation and regulation of insulin secretion in pancreatic beta cells...
  79. pmc Efficient gene delivery and silencing of mouse and human pancreatic islets
    Bruno Lefebvre
    Univ Lille Nord de France, F 59000 Lille, France
    BMC Biotechnol 10:28. 2010
    ..One promising approach toward this goal involves the modification of gene expression profile of beta cells...
  80. doi Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells
    Armen V Gyulkhandanyan
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Biol Chem 283:10184-97. 2008
    ..We observed that Zip1, Zip10, and Zip14 were the most abundantly expressed Zips and ZnT4, ZnT5, and ZnT8 the dominant ZnTs...
  81. doi Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors
    Kar Wah Leung
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:1221-31. 2008
    ..The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to these cells were examined...
  82. pmc SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset
    Henning Gohlke
    Institute of Epidemiology, Helmholtz Zentrum, Neuherberg, Germany
    Rev Diabet Stud 5:25-7. 2008
    It was recently shown that the major allele of the SLC30A8 (zinc transporter 8, ZnT8) single nucleotide polymorphism (SNP) rs13266634 was associated with type 2 diabetes and with reduced insulin secretion in non-diabetic relatives...
  83. pmc A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2693-7. 2008
    ..The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes.
  84. pmc Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse
    Kirstine Juhl
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2755-61. 2008
    ..A further objective was to identify endocrine cell biomarkers, targets of diabetic autoimmunity, and regulatory pathways underlying islet responses to physiological and pathological stimuli...
  85. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    ..A high-ranking candidate, the zinc transporter ZnT8 (Slc30A8), was targeted by autoantibodies in 60-80% of new-onset T1D compared with <2% of controls and <3% ..
  86. doi Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese
    Jie Xiang
    Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 93:4107-12. 2008
    ....
  87. doi Multiple antigens versus single major antigen in type 1 diabetes: arguing for multiple antigens
    Teresa P DiLorenzo
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Diabetes Metab Res Rev 27:778-83. 2011
    ..The recent discovery of novel beta-cell antigens, e.g. ZnT8 and chromogranin A, has taught us that we still have much to learn about the targets of the autoimmune response in ..
  88. pmc Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening
    C Tiberti
    Department of Clinical Sciences, University of Rome Sapienza, Rome, Italy
    Clin Exp Immunol 166:317-24. 2011
    ..decarboxylase (GAD) and tyrosine phosphatase (IA)-2, insulin and islet beta-cell zinc cation efflux transporter (ZnT8) autoantibodies...
  89. pmc Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients
    Speranza Masala
    Sezione di Microbiologia e Virologia, Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, Sassari, Italy
    PLoS ONE 6:e26931. 2011
    ..against one of these proteins, namely MAP3865c, which displays a sequence homology with the β-cell protein zinc transporter 8 (ZnT8) could be cross-reactive with ZnT8 epitopes...
  90. pmc Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
    Lynley D Pound
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Biochem J 421:371-6. 2009
    ..In summary, Slc30a8 gene deletion is accompanied by a modest impairment in insulin secretion without major alterations in glucose metabolism...
  91. ncbi Trajectories of anti-islet autoantibodies before development of type 1 diabetes in interferon-treated hepatitis C patients. Case reports and a literature review
    Kan Nakamura
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki, Japan
    Endocr J 57:947-51. 2010
    ..These clinical courses suggest that IFN-α therapy provoked acute islet autoimmunity and onset of type 1 diabetes. Therefore, during IFN-α therapy, patients should be closely monitored for the occurrence of type 1 diabetes...
  92. pmc Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells
    Kuan Y Chang
    Division of Immunology, Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Int Immunol 21:705-13. 2009
    ..We then examined experimentally the response of NOD.DQ8 mice immunized with peptides derived from the Zinc transporter 8 protein...
  93. pmc Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects
    J M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 95:4712-9. 2010
    b>Zinc transporter 8 (ZnT8) is a newly discovered islet autoantigen in human type 1A diabetes (T1D).
  94. doi Zinc and redox signaling: perturbations associated with cardiovascular disease and diabetes mellitus
    Meika Foster
    Discipline of Nutrition and Metabolism, School of Molecular Bioscience, University of Sydney, Sydney, NSW, Australia
    Antioxid Redox Signal 13:1549-73. 2010
    ..In humans, mutations in the MT-1A and ZnT8 genes, both of which are involved in the maintenance of zinc homeostasis, have been linked with DM development...
  95. pmc Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function
    Malek El Muayed
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 15 755, Chicago, Illinois 60611, USA
    J Endocrinol 206:159-69. 2010
    Genetic studies suggest that Zn transporters such as ZnT8 play a role in insulin secretion by pancreatic beta-cells; however, little is known about the dynamic roles of Zn trafficking pathways on beta-cell physiology...
  96. doi Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity
    Huilan Lin
    Department of Pathology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Biochem J 422:273-83. 2009
    ..Previously we showed that a single amino acid mutation in the yeast vacuolar zinc transporter Zrc1 changed its substrate specificity from Zn2+ to Fe2+ and Mn2+ [Lin, Kumanovics, Nelson, Warner, Ward and Kaplan (..
  97. doi Zinc, zinc transporters and diabetes
    J Rungby
    Department of Endocrinology, Aarhus University Hospital, Tage Hansensgade, DK 8000 Aarhus C, Denmark
    Diabetologia 53:1549-51. 2010
    ..role of zinc in islet function has recently achieved new attention as a consequence of the identification of zinc transporter 8 (ZNT8) in islets, and the association of mutations in the gene for this zinc transporter with glucose ..
  98. doi Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
    N Wijesekara
    Department of Physiology, University of Toronto, 1 King s College Circle Room 3352, Toronto, ON, Canada M5S 1A8
    Diabetologia 53:1656-68. 2010
    ..Zinc transport family member 8 (ZnT8) is a zinc efflux transporter that is highly abundant in beta cells...
  99. doi A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion
    I Kim
    Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea
    Pharmacogenomics J 11:191-8. 2011
    ..These data suggest that the ZnT-8 W325 variant is protective against CsA-induced suppression of insulin secretion. Tolerance of ZnT-8 W325 to calcineurin activity may account for its protective effect in PTDM...
  100. pmc Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    Tamara J Nicolson
    Section of Cell Biology, Division of Medicine, Imperial College London, London, U K
    Diabetes 58:2070-83. 2009
    ..single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes...
  101. doi Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets
    Stephane Cauchi
    CNRS UMR 8090, Institute of Biology, Genomics and Molecular Physiology of Metabolic Diseases, Lille, France
    Mol Genet Metab 100:77-82. 2010
    The C-allele of rs13266634 located in SLC30A8 (ZNT8) has been strongly associated with decreased insulin release and with type 2 diabetes (T2D) susceptibility in some but not all studies...

Research Grants10

  1. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2003
    ..f) characterize the Zn(II)-induced molecular switch in the Zap1 zinc-responsive domain, g) define the role of the Zrc1, Cot1, and Zrt3 transporters in vacuolar zinc storage and detoxification, and h) characterize new transporters ..
  2. Enhancement of Biomarkers for Type 1 Diabetes
    MASSIMO T PIETROPAOLO; Fiscal Year: 2010
    ..of novel biomarkers detecting antibodies directed to IA-2, GAD65 specific epitopes and the newly discovered antigen ZnT8 will further enhance sensitivity and the predictive value of T1DM progression as compared to conventional islet ..
  3. Role of Dietary Zinc Transporter ZIP4 in Pancreatic Cancer
    Min Li; Fiscal Year: 2010
    ..Our preliminary data support that hypothesis that ZIP4 might be a therapeutic target for pancreatic cancer, and this study will lead to meaningful advances for understanding this horrible disease. ..
  4. International Congress of the Immunology of Diabetes Soc
    George Eisenbarth; Fiscal Year: 2002
    ..Travel grants for young investigators will be chosen by numerical rating of submitted abstracts and additional travel funding will be applied to plenary lectures chosen by the international organizing committee. ..