Gene Symbol: SLC30A1
Description: solute carrier family 30 member 1
Alias: ZNT1, ZRC1, zinc transporter 1, solute carrier family 30 (zinc transporter), member 1, znT-1
Species: human
Products:     SLC30A1

Top Publications

  1. Khan I, Rono J, Zhang B, Liu X, Wang M, Wang L, et al. Identification of novel rice (Oryza sativa) HPP and HIPP genes tolerant to heavy metal toxicity. Ecotoxicol Environ Saf. 2019;175:8-18 pubmed publisher
    ..and OsHIPP60 were randomly selected to express in yeast (Saccharomyces cerevisiae) mutants pmrl, cup2, ycf1 and zrc1, exhibiting sensitivity to Mn, Cu, Cd and Zn toxicity, respectively...
  2. Cuillel M, Chevallet M, Charbonnier P, Fauquant C, Pignot Paintrand I, Arnaud J, et al. Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions. Nanoscale. 2014;6:1707-15 pubmed publisher
    ..1, glutamate cysteine ligase modifier subunit, metal responsive element-binding transcription factor 1 and zinc transporter 1 was analyzed by qRT-PCR...
  3. McNeill R, Mason A, Hodson M, Catto J, Southgate J. Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
    ..Expression of the zinc transporter-1 (SLC30A1) gene was also assessed...
  4. Graham Reynolds R, Niemiller M, Revell L. Toward a Tree-of-Life for the boas and pythons: multilocus species-level phylogeny with unprecedented taxon sampling. Mol Phylogenet Evol. 2014;71:201-13 pubmed publisher
    ..the mitochondrial genes CYTB, 12S, and 16S, and the nuclear genes bdnf, bmp2, c-mos, gpr35, rag1, ntf3, odc, and slc30a1, totaling up to 7561 base pairs per taxon...
  5. Thokala S, Bodiga V, Kudle M, Bodiga S. Comparative Response of Cardiomyocyte ZIPs and ZnTs to Extracellular Zinc and TPEN. Biol Trace Elem Res. 2019;: pubmed publisher
    ..TPEN downregulated ZnT1, ZnT2, and ZIP11 mRNAs but upregulated ZnT5, ZIP2, ZIP7, ZIP10, ZIP13, and ZIP14 mRNAs...
  6. Liu Y, Liu T, Jin H, Yin L, Yu H, Bi J. MiR-411 suppresses the development of bladder cancer by regulating ZnT1. Onco Targets Ther. 2018;11:8695-8704 pubmed publisher
    ..The expressions of miR-411 and zinc transporter 1 (ZnT1) in bladder cancer were determined by western blot and real-time PCR...
  7. Wahono N, Ford D, Wakeling L, Valentine R. The presence and response to Zn of ZnT family mRNAs in human dental pulp. Metallomics. 2019;11:613-620 pubmed publisher
    ..b>ZnT1, ZnT5 and ZnT9 mRNAs were detected by RT-PCR in both the secretory odontoblast cells and human dental pulp...
  8. Wilson D. Candida albicans. Trends Microbiol. 2019;27:188-189 pubmed publisher
    ..If present in excess, zinc is detoxified via a Zrc1-dependent mechanism. In C. albicans Zrc1 plays an important role in the generation of zincosomes. C...
  9. Meacham K, Cortés M, Wiggins E, Maass A, Latorre M, Ralle M, et al. Altered zinc balance in the Atp7b-/- mouse reveals a mechanism of copper toxicity in Wilson disease. Metallomics. 2018;10:1595-1606 pubmed publisher
    ..Altered gene expression of Zip5 and ZnT1 zinc transporters indicated a transcriptional homeostatic response, while increased copper/zinc ratios associated ..

More Information


  1. Ronis M, Miousse I, Mason A, Sharma N, Blackburn M, Badger T. Trace element status and zinc homeostasis differ in breast and formula-fed piglets. Exp Biol Med (Maywood). 2015;240:58-66 pubmed publisher
    ..05). Transporter Znt1 mRNA was greater in small intestine of both formula-fed groups and in liver of the milk compared to the breastfed ..
  2. Foster M, Chu A, Petocz P, Samman S. Zinc transporter gene expression and glycemic control in post-menopausal women with Type 2 diabetes mellitus. J Trace Elem Med Biol. 2014;28:448-52 pubmed publisher
    ..of supplementation with zinc (40mg/d) and flaxseed oil (FSO; 2g/d) on the gene expression of zinc transporters (ZnT1, ZnT5, ZnT6, ZnT7, ZnT8, Zip1, Zip3, Zip7, and Zip10) and metallothionein (MT-1A, and MT-2A), and markers of ..
  3. Li L, Li Y, Zhao D, Jin M, Ni H. Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex. Epilepsy Res. 2018;146:103-111 pubmed publisher
    ..expression parameters affected by neonatal seizures, including seizure-induced up-regulated zinc transporter ZnT1/ZIP7, lipid membrane injury-related cPLA2, autophagy marker beclin-1/bcl2, LC3II/LC3I, and its execution molecule ..
  4. Botella H, Peyron P, Levillain F, Poincloux R, Poquet Y, Brandli I, et al. Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages. Cell Host Microbe. 2011;10:248-59 pubmed publisher
    ..encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metallothioneins and zinc exporter ZnT1, were induced during infection...
  5. Giacconi R, Malavolta M, Chiodi L, Boccoli G, Costarelli L, Bonfigli A, et al. ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes. Diabetes Res Clin Pract. 2018;144:102-110 pubmed publisher
    ..from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7...
  6. Li Y, He X, Yang X, Huang K, Luo Y, Zhu L, et al. Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells. Sci Rep. 2015;5:14277 pubmed publisher
    ..addition increased the intracellular zinc concentration and influenced the expression of zinc transporters (Slc30a1 and Slc39a1) in a time-dependent manner...
  7. Kaneko M, Noguchi T, Ikegami S, Sakurai T, Kakita A, Toyoshima Y, et al. Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis. J Neurosci Res. 2015;93:370-9 pubmed publisher
    ..The mRNA expression of ZnT1, -3, -4, -5, -6, -7, and -10 was assessed in the spinal cords of human control subjects...
  8. Chen G, Luo Z, Wei C, Li D, Pan Y. Six indicator genes for zinc (Zn) homeostasis in freshwater teleost yellow catfish Pelteobagrus fulvidraco: molecular characterization, mRNA tissue expression and transcriptional changes to Zn exposure. Biometals. 2018;31:527-537 pubmed publisher
    ..This study cloned and characterized the full-length cDNA sequences of six Zn transport-relevant genes (ZnT1, ZnT5, ZnT7, ZIP4, ZIP5 and MTF-1) from yellow catfish Pelteobagrus fulvidraco...
  9. Florea D, Molina López J, Hogstrand C, Lengyel I, de la Cruz A, Rodríguez Elvira M, et al. Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS). J Trace Elem Med Biol. 2018;49:202-209 pubmed publisher
    ..Expression of 11 out of 24 zinc transporters was analysed, and ZnT1, ZnT4, ZnT5 and ZIP4, which were downregulated by more than 3-fold in whole blood of patients...
  10. Lu Y, Liu Y, Lin M, Chen Y, Lin L. Coordinative modulation of human zinc transporter 2 gene expression through active and suppressive regulators. J Nutr Biochem. 2015;26:351-9 pubmed publisher
    ..However, expressions of MTF-1 target genes such as human ZnT1 and metallothionein IIA were not affected...
  11. Tanimura N, Liao R, Wilson G, Dent M, Cao M, Burstyn J, et al. GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism. Dev Cell. 2018;46:581-594.e4 pubmed publisher
    ..ubiquitination components, and proteins not implicated in erythrocyte biology, including the zinc exporter Slc30a1. Though GATA-1 induced expression of Slc30a1 and the zinc importer Slc39a8, Slc39a8 dominantly increased ..
  12. Su S, Miska K, Fetterer R, Jenkins M, Wong E. Expression of digestive enzymes and nutrient transporters in Eimeria-challenged broilers. Exp Parasitol. 2015;150:13-21 pubmed publisher
    ..CAT2, EAAT3, LAT1, y(+)LAT1 and y(+)LAT2), sugar transporters (GLUT1, GLUT2, GLUT5 and SGLT1), zinc transporter (ZnT1) and an antimicrobial peptide (LEAP2). Duodenum, jejunum, ileum and ceca were collected 7 days post challenge. E...
  13. Mellone M, Pelucchi S, Alberti L, Genazzani A, Di Luca M, Gardoni F. Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density. J Neurochem. 2015;132:159-68 pubmed publisher
    ..Modulation of ZNT-1 expression in hippocampal neurons determined a shrinkage of dendritic spines and a reduction of GluN2A surface levels supporting the involvement of ZNT-1 in the dynamics of the excitatory synapse. ..
  14. Xie C, Oganov A, Li D, Debela T, Liu N, Dong D, et al. Effects of carbon vacancies on the structures, mechanical properties, and chemical bonding of zirconium carbides: a first-principles study. Phys Chem Chem Phys. 2016;18:12299-306 pubmed publisher
    ..using first-principles, we have calculated the properties of a number of stable and metastable zirconium carbides ZrC1-x (x = 0 and 1/n, n = 2-8) which were predicted by the evolutionary algorithm USPEX...
  15. Liu C, Guo H, Cheng X, Shao M, Wu C, Wang S, et al. Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells. Oncotarget. 2015;6:29428-39 pubmed publisher
    ..In silico and biochemical analyses suggested SLC30A1, SERPINB2 and AKR1C1, among the upregulated genes, as target for miR-182 and miR-185, respectively...
  16. Lv M, Fu X, Hu L, Yue X, Han X. The Expression of Zinc Transporters Changed in the Intestine of Weaned Pigs Exposed to Zinc Chitosan Chelate. Biol Trace Elem Res. 2016;174:328-334 pubmed
    ..Zinc concentration in the liver and kidney did not differ between treatments. The mRNA expressions of ZnT1, ZIP4, and ZIP5 in CS-Zn treatment were all upregulated (p < 0...
  17. Maxel T, Svendsen P, Smidt K, Lauridsen J, Brock B, Pedersen S, et al. Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome. Front Endocrinol (Lausanne). 2017;8:38 pubmed publisher
    ..levels of zinc transporter ZIP9, a recently identified androgen receptor, and zinc efflux transporter ZNT1 were investigated, alongside lipid profile and markers of glucose metabolism [insulin degrading enzyme, retinol-..
  18. Kitayama T, Morita K, Motoyama N, Dohi T. Down-regulation of zinc transporter-1 in astrocytes induces neuropathic pain via the brain-derived neurotrophic factor - K+-Cl- co-transporter-2 signaling pathway in the mouse spinal cord. Neurochem Int. 2016;101:120-131 pubmed publisher
    ..previously demonstrated, using a DNA microarray analysis, the down-regulated expression of the slc30a1 gene (zinc transporter 1, ZnT1) in a neuropathic pain model induced by partial sciatic nerve ligation (PSNL)...
  19. Hennigar S, Kelley A, McClung J. Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review. Adv Nutr. 2016;7:735-46 pubmed publisher
    ..ZIP6 (SLC39A6), ZIP7 (SLC39A7), ZIP8 (SLC39A8), ZIP10 (SLC39A10), ZIP14 (SLC39A14), zinc transporter (ZnT)1 (SLC30A1), ZnT2 (SLC30A2), ZnT4 (SLC30A4), ZnT5 (SLC30A5), ZnT6 (SLC30A6), ZnT7 (SLC30A7), ZnT9 (SLC30A9), and/or ..
  20. Cho M, Hu G, Caza M, Horianopoulos L, Kronstad J, Jung W. Vacuolar zinc transporter Zrc1 is required for detoxification of excess intracellular zinc in the human fungal pathogen Cryptococcus neoformans. J Microbiol. 2018;56:65-71 pubmed publisher
    ..In the model fungus Saccharomyces cerevisiae, a vacuolar zinc transporter, Zrc1, plays important roles in the storage and detoxification of excess intracellular zinc to protect the cell...
  21. Zong N, Ma S, Wang Z. Localization of zinc transporters in the spinal cord of cynomolgus monkey. J Chem Neuroanat. 2017;82:56-59 pubmed publisher
    ..In the present study, we examined the distribution of ZnT1-10 proteins in the spinal cord of cynomolgus monkey...
  22. Meng J, Zhang L, Li L, Li C, Wang T, Zhang G. Transcription factor CgMTF-1 regulates CgZnT1 and CgMT expression in Pacific oyster (Crassostrea gigas) under zinc stress. Aquat Toxicol. 2015;165:179-88 pubmed publisher
    ..we cloned MTF-1 in oysters and examined its regulation mechanism for its classic target genes, including MTs and ZnT1 under zinc exposure conditions...
  23. Ogawa Y, Kinoshita M, Shimada S, Kawamura T. Zinc and Skin Disorders. Nutrients. 2018;10: pubmed publisher
    ..Zn transporter (ZnT)2 in the secretory vesicles of mammary glands), and epidermodysplasia verruciformis (ZnT1 in the epidermal keratinocytes)...
  24. Huang D, Zhuo Z, Fang S, Yue M, Feng J. Different Zinc Sources Have Diverse Impacts on Gene Expression of Zinc Absorption Related Transporters in Intestinal Porcine Epithelial Cells. Biol Trace Elem Res. 2016;173:325-32 pubmed publisher
    ..Different zinc sources improved the expression of metallothionein1 (MT1) and zinc transporter SLC30A1 (ZnT1) messenger RNA (mRNA) compared with the control (P < 0.05), while ZIP4 decreased (P < 0...
  25. Huang D, Hu Q, Fang S, Feng J. Dosage Effect of Zinc Glycine Chelate on Zinc Metabolism and Gene Expression of Zinc Transporter in Intestinal Segments on Rat. Biol Trace Elem Res. 2016;171:363-370 pubmed publisher
    ..In the jejunum, Zip5 mRNA expression in 60 mg Zn/kg was higher compared with other groups (P < 0.05). ZnT1 mRNA in duodenum was numerically increased with the rising levels of zinc content and was significantly higher (PÂ..
  26. Chevallet M, Gallet B, Fuchs A, Jouneau P, Um K, Mintz E, et al. Metal homeostasis disruption and mitochondrial dysfunction in hepatocytes exposed to sub-toxic doses of zinc oxide nanoparticles. Nanoscale. 2016;8:18495-18506 pubmed
    ..Gene expression analysis highlighted zinc homeostasis disruptions as shown by metallothionein 1X and zinc transporter 1 and 2 (ZnT1, ZnT2) over-expression...
  27. Gehrke S, Poncio da Silva P, Calvo Guirado J, Delgado Ruiz R, Dedavid B, Aline Nagasawa M, et al. Mechanical behavior of zirconia and titanium abutments before and after cyclic load application. J Prosthet Dent. 2016;116:529-535 pubmed publisher
    ..The longitudinal and transverse axes of 4 experimental groups (Tic1, Tic2, Zrc1, and Zrc2) were analyzed (vertical/horizontal adjustment) using a scanning electron microscope at ×1000 ..
  28. Cai Y, Kirschke C, Huang L. SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the ?-cells. J Mol Histol. 2018;49:133-145 pubmed publisher
    ..expression and cellular localization in the pancreatic ?-cells between humans and mice, we examined all members (ZNT1-10) of the ZNT family in pancreatic islets and in ?-cell lines derived from both species using immunohistochemistry ..
  29. Callegaro G, Forcella M, Melchioretto P, Frattini A, Gribaldo L, Fusi P, et al. Toxicogenomics applied to in vitro Cell Transformation Assay reveals mechanisms of early response to cadmium. Toxicol In Vitro. 2018;48:232-243 pubmed publisher
    ..Metallothioneins represent the earliest cell response, together with Slc30a1 encoding for a ZnT-1 zinc exporter...
  30. Xia J, Guo Z, Yang Z, Zhu X, Kang S, Yang X, et al. Proteomics-based identification of midgut proteins correlated with Cry1Ac resistance in Plutella xylostella (L.). Pestic Biochem Physiol. 2016;132:108-17 pubmed publisher
    ..actin, glycosylphosphatidylinositol anchor attachment 1 protein (GAA1) and solute carrier family 30 member 1 (SLC30A1)...
  31. Kozela E, Juknat A, Gao F, Kaushansky N, Coppola G, Vogel Z. Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. J Neuroinflammation. 2016;13:136 pubmed publisher
    ..oxidative stress modulators with potent anti-inflammatory activity that are controlled by Nfe2l2/Nrf2 (Mt1, Mt2a, Slc30a1, Hmox1)...
  32. Zetzsche A, Schunter N, Zentek J, Pieper R. Accumulation of copper in the kidney of pigs fed high dietary zinc is due to metallothionein expression with minor effects on genes involved in copper metabolism. J Trace Elem Med Biol. 2016;35:1-6 pubmed publisher
    ..Kidney mRNA expression of Zn transporter ZnT1 and ZIP4, genes involved in Cu metabolism (Ctr1, Atox1, SOD1, ATP7A, CCS, CP) and divalent metal ion transport (..
  33. Holland T, Killilea D, Shenvi S, King J. Acute changes in cellular zinc alters zinc uptake rates prior to zinc transporter gene expression in Jurkat cells. Biometals. 2015;28:987-96 pubmed publisher
    ..After 120 min, the expression of metallothionein (positive control) increased, as well as the zinc exporter, ZnT1; however, the expression of zinc importers did not change during this time period...
  34. Ishida T, Yamaguchi T, Takechi S. 3-Hydro-2,2,5,6-tetramethylpyrazine: A novel inducer of zinc transporter-1 in HepG2 human hepatocellular carcinoma cells. Arch Biochem Biophys. 2015;580:57-63 pubmed publisher
    ..These results suggest that DHP-3 is a novel ZnT-1 inducer and acts via activation of the MTF-1 signaling pathway. Additionally, the activation of MTF-1 by this compound likely occurs through oxidative stress. ..
  35. Zogzas C, Mukhopadhyay S. Putative metal binding site in the transmembrane domain of the manganese transporter SLC30A10 is different from that of related zinc transporters. Metallomics. 2018;10:1053-1064 pubmed publisher
    ..Site A of zinc-transporting CDFs, such as SLC30A1/ZnT1, have a HXXXD motif, but manganese transporters, such as SLC30A10, harbor a NXXXD motif...
  36. Wang B, Zhang J, Chen C, Xu G, Qin X, Hong Y, et al. The size of zinc oxide nanoparticles controls its toxicity through impairing autophagic flux in A549 lung epithelial cells. Toxicol Lett. 2018;285:51-59 pubmed publisher
    ..flux (the increase of p62 expression), the release of intracellular zinc ions (the increase of FluoZin-3 signal and ZnT1 mRNA expression), mitochondrial damage (the decrease of TMRE signal), lysosomal dysfunction (the aberrant ..
  37. Wang H, Wang Y, Bo Q, Ji Y, Liu L, Hu Y, et al. Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice. Reprod Toxicol. 2016;63:174-82 pubmed publisher
    ..Conversely, embryonic Zn concentration was reduced. Moreover, placental Znt1 and Znt2, two zinc transporters, were down-regulated in Cd-exposed mice...
  38. Yin H, Sumners L, Dalloul R, Miska K, Fetterer R, Jenkins M, et al. Changes in expression of an antimicrobial peptide, digestive enzymes, and nutrient transporters in the intestine of E. praecox-infected chickens. Poult Sci. 2015;94:1521-6 pubmed publisher
    ..anionic (EAAT3), and L-type (LAT1) amino acid transporters, the peptide transporter PepT1 and the zinc transporter ZnT1. Other transporters were downregulated either at d3 or d6...
  39. Rafalo A, Zadrozna M, Nowak B, Kotarska K, Wiatrowska K, Pochwat B, et al. The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2017;72:36-48 pubmed publisher
    ..Messenger RNA and proteins of ZnT1, ZnT3, ZnT4, ZnT5, ZnT6 and MT1/2 were measured in the prefrontal cortex (PFC) and hippocampus (Hp) of rats ..
  40. Giacconi R, Costarelli L, Malavolta M, Cardelli M, Galeazzi R, Piacenza F, et al. Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation. Biofactors. 2015;41:414-23 pubmed publisher
    ..associated with decreased free cytosolic zinc in PBMCs and an upregulation of zinc transporters ZIP2, ZIP8, and Znt1. Moreover, Leu- subjects displayed significant decrement of inflammatory mediators such as MCP-1, TNF-α, and ..
  41. Ben Mimouna S, Boughammoura S, Chemek M, Haouas Z, Banni M, Messaoudi I. Disruption of the zinc metabolism in rat fœtal brain after prenatal exposure to cadmium. Chem Biol Interact. 2018;286:88-95 pubmed publisher
    ..with inhibition of that encoding the transporters involved in the output of the Zn into the extracellular medium (ZnT1 and ZnT3)...
  42. Hennigar S, McClung J. Hepcidin Attenuates Zinc Efflux in Caco-2 Cells. J Nutr. 2016;146:2167-2173 pubmed
    ..and the zinc transporters zrt-/irt-like protein (ZIP)4 (SLC39A4), ZIP5 (SLC39A5), ZIP14 (SLC39A14), and zinc transporter 1 (ZnT1) (SLC30A1) was determined...
  43. Nemmiche S, Guiraud P. Cadmium-induced oxidative damages in the human BJAB cells correlate with changes in intracellular trace elements levels and zinc transporters expression. Toxicol In Vitro. 2016;37:169-177 pubmed publisher
    ..Cd exposure increased the expression of DMT1 and caused an up-regulation of ZnT1. However, the T calcium channel alpha1G subunit could not be detected...
  44. Hardyman J, Tyson J, Jackson K, Aldridge C, Cockell S, Wakeling L, et al. Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc. Metallomics. 2016;8:337-43 pubmed publisher
    ..Exceptions were the zinc effluxer ZnT1 and a suite of metallothionein genes, suggesting that responses of other genes to zinc are usually buffered by ..
  45. Levy S, Beharier O, Etzion Y, Mor M, Buzaglo L, Shaltiel L, et al. Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels. J Biol Chem. 2009;284:32434-43 pubmed publisher
  46. Zhang L, Wang X, Stoltenberg M, Danscher G, Huang L, Wang Z. Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. Brain Res Bull. 2008;77:55-60 pubmed publisher
    ..We found that all the ZNTs tested (ZNT1, 3, 4, 5, 6, 7) were extensively present in the Abeta-positive plaques in the cortex of human AD brains, and the ..
  47. Quesada I, Bustos M, Blay M, Pujadas G, Ardevol A, Salvadó M, et al. Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem. 2011;22:153-63 pubmed publisher
    ..chain reaction, of zinc-binding metallothioneins and of plasma membrane zinc exporter ZnT1 (SLC30A1), while enhancing the expression of cellular zinc importers ZIP1 (SLC39A1) and ZIP4 (SLC39A4)...
  48. Bodiga V, Thokala S, Kovur S, Bodiga S. Zinc Dyshomeostasis in Cardiomyocytes after Acute Hypoxia/Reoxygenation. Biol Trace Elem Res. 2017;179:117-129 pubmed publisher
    ..Immunoblotting analysis revealed that hypoxia increased the expression of ZnT1, but reoxygenation significantly increased the expression of ZnTs 2 and 5...
  49. Cousins R. Gastrointestinal factors influencing zinc absorption and homeostasis. Int J Vitam Nutr Res. 2010;80:243-8 pubmed publisher
    ..Metallothionein, an intracellular metal buffer, and the transporter ZnT1 at the basolateral membrane, regulate the amount of zinc released to the portal circulation for systemic ..
  50. Meng J, Zhang X, Tan S, Zhao K, Yang Z. Genome-wide identification of Cd-responsive NRAMP transporter genes and analyzing expression of NRAMP 1 mediated by miR167 in Brassica napus. Biometals. 2017;30:917-931 pubmed publisher
    ..define whether BnNRAMP1b was specific for Cd transport, a yeast (wild-type, BY4741) system with its mutants (ycf1, zrc1, and smf1) defective in transport activity of Cd, Zn and Mn, respectively were tested...
  51. Chen G, Hogstrand C, Luo Z, Zhang D, Ling S, Wu K. Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr. 2017;118:570-579 pubmed publisher
    ..In the fore-intestine, dietary Zn up-regulated mRNA levels of ZnT1, ZnT5, ZnT7, metallothionein (MT) and metal response element-binding transcription factor-1 (MTF-1), but down-..
  52. Lyubartseva G, Smith J, Markesbery W, Lovell M. Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. Brain Pathol. 2010;20:343-50 pubmed publisher
    ..Overall, our results suggest that alterations in Zn transport proteins may contribute to the pathology observed in PCAD subjects before onset of clinical symptoms. ..
  53. Beharier O, Etzion Y, Levi S, Mor M, Mor M, Dror S, et al. The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected]. Ann N Y Acad Sci. 2010;1188:87-95 pubmed publisher
    ..Finally, in a pilot study, ZnT-1 expression was found to be augmented in the atria of AF patients. These findings position ZnT-1 as a probable missing link in the mechanism underlying atrial tachycardia remodeling. ..
  54. Lovell M, Smith J, Xiong S, Markesbery W. Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease. Neurotox Res. 2005;7:265-71 pubmed
  55. Ling S, Luo Z, Chen G, Zhang D, Liu X. Waterborne Zn influenced Zn uptake and lipid metabolism in two intestinal regions of juvenile goby Synechogobius hasta. Ecotoxicol Environ Saf. 2018;148:578-584 pubmed publisher
    ..18mg Zn/l group, in parallel with the highest expressions of ZnT1, ZIP4, ZIP5, 6PGD, FAS, ICDH, PPAR?, PPAR?, ZNF202, KLF4 and KLF7, and with the highest FAS, 6PGD and G6PD ..
  56. Golan Y, Berman B, Assaraf Y. Heterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementation. J Biol Chem. 2015;290:9050-63 pubmed publisher
    ..We show that ZnT1, -2, -3, and -4 form stable heterodimers at distinct intracellular compartments, some of which are completely ..
  57. Wang Y, Li K, Mao L, Hu X, Zhao W, Hu A, et al. Effects of exogenous zinc on cell cycle, apoptosis and viability of MDAMB231, HepG2 and 293 T cells. Biol Trace Elem Res. 2013;154:418-26 pubmed publisher
    ..Additionally, the mRNA expression levels of ZnT and ZIP families in the three cell lines, when treated with high concentration of ZnSO4, increased and decreased corresponding to their functions, respectively. ..
  58. Malavolta M, Costarelli L, Giacconi R, Basso A, Piacenza F, Pierpaoli E, et al. Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. Exp Gerontol. 2017;99:35-45 pubmed publisher
    ..relocation of labile Zn and altered expression of genes involved in the response to Zn toxicity, including SLC30A1, SLC39A6, SLC30A5, SLC30A10 and metallothioneins, indicating that senescent cells have altered zinc homeostasis...
  59. Rafalo Ulinska A, Piotrowska J, Kryczyk A, Opoka W, Sowa Kucma M, Misztak P, et al. Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims. J Psychiatr Res. 2016;83:220-229 pubmed publisher
    ..Protein levels of ZnT1, ZnT3, ZnT4, ZnT5 and ZnT6 were measured in postmortem brain tissue from two different cohorts...
  60. Devergnas S, Chimienti F, Naud N, Pennequin A, Coquerel Y, Chantegrel J, et al. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Biochem Pharmacol. 2004;68:699-709 pubmed
  61. Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I. A role for ZnT-1 in regulating cellular cation influx. Biochem Biophys Res Commun. 2004;323:1145-50 pubmed
    ..Furthermore, ZnT-1 may play a role in cellular ion homeostasis and thereby confer protection against pathophysiological events linked to cellular Ca(2+) or Zn(2+) permeation and cell death. ..
  62. Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed
  63. Zhang L, Wang X, Sun D, Liu X, Hu X, Kong F. Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. Mol Biol Rep. 2008;35:595-600 pubmed
    ..LIV-1 mRNA expression of SDG group increases compared with BD group. In FS group, it significantly increases nearly 9 times than that in BD group (P < 0. 005). ..
  64. Etzion Y, Ganiel A, Beharier O, Shalev A, Novack V, Volvich L, et al. Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study. J Cardiovasc Electrophysiol. 2008;19:157-64 pubmed
    ..62, 0.31; P = 0.002, P = 0.04, respectively). This pilot study provides evidence for increased ZnT-1 expression in the atria of patients with atrial fibrillation. ..
  65. Lazarczyk M, Pons C, Mendoza J, Cassonnet P, Jacob Y, Favre M. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J Exp Med. 2008;205:35-42 pubmed
    ..We report that EVER1 and EVER2 proteins form a complex and interact with the zinc transporter 1 (ZnT-1), as shown by yeast two-hybrid screening, GST pull-down, and immunoprecipitation experiments...
  66. Mentewab A, Matheson K, Adebiyi M, Robinson S, Elston B. RNA-seq analysis of the effect of kanamycin and the ABC transporter AtWBC19 on Arabidopsis thaliana seedlings reveals changes in metal content. PLoS ONE. 2014;9:e109310 pubmed publisher
    ..Most notably the expression of several zinc ion binding proteins, including ZINC TRANSPORTER 1 PRECURSOR (ZIP1) was increased, suggesting abnormal zinc uptake...
  67. Shusterman E, Beharier O, Shiri L, Zarivach R, Etzion Y, Campbell C, et al. ZnT-1 extrudes zinc from mammalian cells functioning as a Zn(2+)/H(+) exchanger. Metallomics. 2014;6:1656-63 pubmed publisher
    ..Our results demonstrate that ZnT-1 extrudes zinc from mammalian cells by functioning as a Zn(2+)/H(+) exchanger. ..
  68. Mor M, Beharier O, Levy S, Kahn J, Dror S, Blumenthal D, et al. ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling. Am J Physiol Cell Physiol. 2012;303:C192-203 pubmed publisher
    ..1 and CaV3.2 through activation of Ras-ERK signaling. The augmentation of CaV3.1 currents by Ras-ERK activation is associated with enhanced trafficking of the channel to the plasma membrane. ..
  69. Noh H, Paik H, Kim J, Chung J. The alteration of zinc transporter gene expression is associated with inflammatory markers in obese women. Biol Trace Elem Res. 2014;158:1-8 pubmed publisher
    ..b>ZnT1 and Zip1 were the most abundantly expressed zinc transporters in leukocytes...
  70. Dos Santos Rocha P, de Castro Amorim A, de Sousa A, do Monte S, da Mata Sousa L, do Nascimento Nogueira N, et al. Expression of the zinc transporters genes and metallothionein in obese women. Biol Trace Elem Res. 2011;143:603-11 pubmed publisher
    ..01). The study shows that there are alterations in the biochemical parameters of zinc in obese patients assessed, as well as higher expression of the codifying gene metallothionein, when compared to the investigated zinc transporters. ..
  71. Zemann N, Zemann A, Klein P, Elmadfa I, Huettinger M. Differentiation- and polarization-dependent zinc tolerance in Caco-2 cells. Eur J Nutr. 2011;50:379-86 pubmed publisher
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    ..zinc on growth performance, serum zinc (Zn) content and messenger RNA (mRNA) expression of Zn transporters (ZnT1/ZnT2/ZnT5/ZIP4/DMT1) of young growing pigs...
  73. Iguchi K, Otsuka T, Usui S, Ishii K, Onishi T, Sugimura Y, et al. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. J Androl. 2004;25:154-61 pubmed
    ..AIDL cells exhibited a lower expression of zinc transporter 1 (ZnT1) and higher expression of ZnT3 than LNCaP cells...
  74. Mónica A, Lautaro B, Fernando P, Miguel A. Calcium and zinc decrease intracellular iron by decreasing transport during iron repletion in an in vitro model. Eur J Nutr. 2018;57:2693-2700 pubmed publisher
    ..on iron uptake and transport, intracellular Fe and Zn levels and mRNA expression of DMT1, ferroportin, Zip4 and ZnT1 in an in vitro model...
  75. Urani C, Melchioretto P, Gribaldo L. Regulation of metallothioneins and ZnT-1 transporter expression in human hepatoma cells HepG2 exposed to zinc and cadmium. Toxicol In Vitro. 2010;24:370-4 pubmed publisher
    ..Immunofluorescence technique provided evidence that high levels of ZnT-1 measured by biochemical techniques, are related to an increased localization of the transporter at the plasma membrane. ..
  76. Beyer N, Coulson D, Heggarty S, Ravid R, Hellemans J, Irvine G, et al. Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. J Alzheimers Dis. 2012;29:863-73 pubmed publisher
    ..Altered protein levels of the membrane Zn2+ transporters ZnT1, ZnT4, and ZnT6 have been reported in AD postmortem brain tissue...
  77. Overbeck S, Uciechowski P, Ackland M, Ford D, Rink L. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol. 2008;83:368-80 pubmed
    ..These data provide insight into the regulation of intracellular zinc homeostasis in cells of the immune system and may explain the variable effects of zinc deficiency on different leukocyte subsets. ..
  78. Mimouna S, Chemek M, Boughammoura S, Banni M, Messaoudi I. Early-Life Exposure to Cadmium Triggers Distinct Zn-Dependent Protein Expression Patterns and Impairs Brain Development. Biol Trace Elem Res. 2018;184:409-421 pubmed publisher
    ..No significant changes on the expression of genes encoding other Zn-dependent proteins and factors such as ZnT1, ZIP12, NF-κB, and Zif268...
  79. Farthing E, Menguer P, Fett J, Williams L. OsMTP11 is localised at the Golgi and contributes to Mn tolerance. Sci Rep. 2017;7:15258 pubmed publisher
    ..rescues the Mn-hypersensitivity of the pmr1 yeast mutant but only slightly alleviates the Zn sensitivity of the zrc1 cot1 yeast mutant...
  80. Zhu Q, Guo S, Yuan S, Lv Z, Zheng J, Xia H. Heat indicators of oxidative stress, inflammation and metal transport show dependence of cadmium pollution history in the liver of female zebrafish. Aquat Toxicol. 2017;191:1-9 pubmed publisher
    ..mRNA levels of IL-6, IL-1?, TNF-?, iNOS and NF-?B), 8 molecular indicators of metal transport (mRNA levels of, ZnT1, ZnT5, ZIP8, ZIP10, ATP7A, ATP7B and CTR1)...