SLC2A9

Summary

Gene Symbol: SLC2A9
Description: solute carrier family 2 member 9
Alias: GLUT9, GLUTX, UAQTL2, URATv1, solute carrier family 2, facilitated glucose transporter member 9, GLUT-9, glucose transporter type 9, human glucose transporter-like protein-9, solute carrier family 2 (facilitated glucose transporter), member 9, urate voltage-driven efflux transporter 1
Species: human
Products:     SLC2A9

Top Publications

  1. Phay J, Hussain H, Moley J. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). Genomics. 2000;66:217-20 pubmed
    ..to a novel member of the glucose transporter family (GLUT1-5) was identified (GLUT9; HGMW-approved symbol SLC2A9), and it encodes a putative transporter of 540 amino acids...
  2. Shima Y, Nozu K, Nozu Y, Togawa H, Kaito H, Matsuo M, et al. Recurrent EIARF and PRES with severe renal hypouricemia by compound heterozygous SLC2A9 mutation. Pediatrics. 2011;127:e1621-5 pubmed publisher
    ..any mutations in the URAT1 gene were recently found to have a mutation in the glucose transporter 9 (GLUT9) gene (SLC2A9 [solute carrier family 2, member 9])...
  3. Brandstätter A, Kiechl S, Kollerits B, Hunt S, Heid I, Coassin S, et al. Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI. Diabetes Care. 2008;31:1662-7 pubmed publisher
    ..Recently, the putative fructose transporter SLC2A9 was reported to influence uric acid levels...
  4. Dalbeth N, House M, Gamble G, Horne A, Pool B, Purvis L, et al. Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load. Ann Rheum Dis. 2013;72:1868-73 pubmed publisher
    b>SLC2A9 is a strong genetic risk factor for hyperuricaemia and gout. SLC2A9 (GLUT9) is a high capacity urate transporter and reportedly transports glucose and fructose...
  5. Brandstätter A, Lamina C, Kiechl S, Hunt S, Coassin S, Paulweber B, et al. Sex and age interaction with genetic association of atherogenic uric acid concentrations. Atherosclerosis. 2010;210:474-8 pubmed publisher
    High serum uric acid levels are associated with gout, atherosclerosis and cardiovascular disease. Three genes (SLC2A9, ABCG2, and SLC17A3) were reported to be involved in the regulation of uric acid levels.
  6. Tu H, Chen C, Tovosia S, Ko A, Lee C, Ou T, et al. Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders. Ann Rheum Dis. 2010;69:887-90 pubmed publisher
    To study the associations of gout, tophi and uric acid levels with the gout-related SLC2A9 (solute carrier family 2, member 9) single nucleotide polymorphisms (SNPs) between two different racial groups.
  7. Anzai N, Ichida K, Jutabha P, Kimura T, Babu E, Jin C, et al. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem. 2008;283:26834-8 pubmed publisher
    ..model of transcellular urate transport in the kidney; urate [corrected] is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter 1).
  8. Doring A, Gieger C, Mehta D, Gohlke H, Prokisch H, Coassin S, et al. SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet. 2008;40:430-6 pubmed publisher
    ..n = 1,644), the most significant SNPs associated with uric acid concentrations mapped within introns 4 and 6 of SLC2A9, a gene encoding a putative hexose transporter (effects: -0.23 to -0.36 mg/dl per copy of the minor allele)...
  9. Merriman T, Dalbeth N. The genetic basis of hyperuricaemia and gout. Joint Bone Spine. 2011;78:35-40 pubmed publisher
    ..serum urate concentrations have identified two major regulators of hyperuricaemia- the renal urate transporters SLC2A9 and ABCG2...

More Information

Publications65

  1. Bibee K, Illsley N, Moley K. Asymmetric syncytial expression of GLUT9 splice variants in human term placenta and alterations in diabetic pregnancies. Reprod Sci. 2011;18:20-7 pubmed publisher
    ..Human GLUT9, existing as 2 isoforms, is a novel member of the transporter family...
  2. Karns R, Zhang G, Sun G, Rao Indugula S, Cheng H, Havas Augustin D, et al. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. Ann Hum Genet. 2012;76:121-7 pubmed publisher
    ..Our study replicated four previously reported SUA loci (SLC2A9, ABCG2, RREB1, and SLC22A12). The strongest association was found with a SNP in SLC2A9 (rs13129697, P=2...
  3. Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, et al. Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am J Hum Genet. 2008;83:744-51 pubmed publisher
    ..hypouricemic patients without URAT1 mutations, as well as genome-wide association studies between urate and SLC2A9 (also called GLUT9), imply that GLUT9 could be another causative gene of renal hypouricemia...
  4. Richardson S, Neama G, Phillips T, Bell S, Carter S, Moley K, et al. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage. 2003;11:92-101 pubmed
    ..Expression of GLUT1, GLUT3 and GLUT9 proteins in normal human articular cartilage was confirmed by immunohistochemistry...
  5. Stiburkova B, Taylor J, Marinaki A, Sebesta I. Acute kidney injury in two children caused by renal hypouricaemia type 2. Pediatr Nephrol. 2012;27:1411-5 pubmed publisher
    ..Type 1 is caused by a loss-of-function mutation in the SLC22A12 gene (OMIM #220150), while type 2 is caused by defects in the SLC2A9 gene (OMIM #612076).
  6. Yang Q, Kottgen A, Dehghan A, Smith A, Glazer N, Chen M, et al. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet. 2010;3:523-30 pubmed publisher
    ..with serum urate levels (P=4×10(-8) to 2×10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Only 2 loci (SLC2A9, ABCG2) showed genome-wide significant association with gout...
  7. Kimura T, Takahashi M, Yan K, Sakurai H. Expression of SLC2A9 isoforms in the kidney and their localization in polarized epithelial cells. PLoS ONE. 2014;9:e84996 pubmed publisher
    ..k.a. URATv1), as one of the most influential genes for serum urate levels...
  8. Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, et al. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. PLoS ONE. 2009;4:e7729 pubmed publisher
    ..In the second study, the same genetic polymorphisms were analyzed for association with CAD...
  9. Witkowska K, Smith K, Yao S, Ng A, O Neill D, Karpinski E, et al. Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses. Am J Physiol Renal Physiol. 2012;303:F527-39 pubmed publisher
    Human SLC2A9 (GLUT9) is a novel high-capacity urate transporter belonging to the facilitated glucose transporter family...
  10. Li C, Han L, Levin A, Song H, Yan S, Wang Y, et al. Multiple single nucleotide polymorphisms in the human urate transporter 1 (hURAT1) gene are associated with hyperuricaemia in Han Chinese. J Med Genet. 2010;47:204-10 pubmed publisher
    ..In conjunction with other studies, our results suggest that there are multiple genetic variants within or near hURAT1 that are associated with susceptibility to HUA in Han Chinese, including a novel SNP located in intron 3. ..
  11. Manolescu A, Augustin R, Moley K, Cheeseman C. A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. Mol Membr Biol. 2007;24:455-63 pubmed
    ..Finally, the possibility that the translocation binding site may not be the sole determinant of substrate specificity for these proteins is examined. ..
  12. Guan M, Zhou D, Ma W, Chen Y, Zhang J, Zou H. Association of an intronic SNP of SLC2A9 gene with serum uric acid levels in the Chinese male Han population by high-resolution melting method. Clin Rheumatol. 2011;30:29-35 pubmed publisher
    b>SLC2A9 is a novel identified urate transporter influencing uric acid metabolism. It has been suggested that the single-nucleotide polymorphisms in SLC2A9 may affect the serum UA levels...
  13. Rule A, de Andrade M, Matsumoto M, Mosley T, Kardia S, Turner S. Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families. Rheumatology (Oxford). 2011;50:871-8 pubmed publisher
    b>SLC2A9 gene variants associate with serum uric acid in white populations, but little is known about African American populations...
  14. Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, et al. Association of four genetic loci with uric acid levels and reduced renal function: the J-SHIPP Suita study. Am J Nephrol. 2010;32:279-86 pubmed publisher
    ..We also identified a common nonsense mutation, W258X, responsible for renal hypouricemia. Here, we investigated clinical implications of these genetic variants by cross-sectional and longitudinal genetic epidemiological analysis...
  15. Hollis Moffatt J, Xu X, Dalbeth N, Merriman M, Topless R, Waddell C, et al. Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand M?ori, Pacific Island, and Caucasian case-control sample sets. Arthritis Rheum. 2009;60:3485-92 pubmed publisher
    To examine the role of genetic variation in the renal urate transporter SLC2A9 in gout in New Zealand sample sets of M?ori, Pacific Island, and Caucasian ancestry and to determine if the M?ori and Pacific Island samples could be useful ..
  16. Cheeseman C. Solute carrier family 2, member 9 and uric acid homeostasis. Curr Opin Nephrol Hypertens. 2009;18:428-32 pubmed publisher
    ..of the recently identified urate transporter, solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9), in the renal handling of urate...
  17. Dinour D, Gray N, Ganon L, Knox A, Shalev H, Sela B, et al. Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2. Nephrol Dial Transplant. 2012;27:1035-41 pubmed publisher
    ..We have recently shown that loss-of-function homozygous mutations of another UA transporter, GLUT9, cause a severe type of hereditary renal hypouricemia with similar complications (RHUC2).
  18. Stark K, Reinhard W, Neureuther K, Wiedmann S, Sedlacek K, Baessler A, et al. Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS ONE. 2008;3:e1948 pubmed publisher
    Serum uric acid (UA) levels have recently been shown to be genetically influenced by common polymorphisms in the GLUT9 gene in two genome-wide association analyses of Italian and British populations...
  19. Li S, Sanna S, Maschio A, Busonero F, Usala G, Mulas A, et al. The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet. 2007;3:e194 pubmed
    ..They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney...
  20. Liu W, Hung C, Chen S, Lin M, Chen L, Hwang D, et al. The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese. Exp Diabetes Res. 2011;2011:527520 pubmed publisher
    The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion...
  21. Sulem P, Gudbjartsson D, Walters G, Helgadottir H, Helgason A, Gudjonsson S, et al. Identification of low-frequency variants associated with gout and serum uric acid levels. Nat Genet. 2011;43:1127-30 pubmed publisher
    ..This variant is close to a common variant previously associated with serum uric acid levels. This work illustrates how whole-genome sequencing data allow the detection of associations between low-frequency variants and complex traits. ..
  22. Dehghan A, Kottgen A, Yang Q, Hwang S, Kao W, Rivadeneira F, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372:1953-61 pubmed publisher
    ..Top SNPs in each locus were: missense rs16890979 in SLC2A9 (p=7.0 x 10(-168) and 2...
  23. McArdle P, Parsa A, Chang Y, Weir M, O Connell J, Mitchell B, et al. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. Arthritis Rheum. 2008;58:2874-81 pubmed publisher
    ..Followup genotyping revealed that a nonsynonymous coding SNP (Val253Ile; rs16890979) in GLUT9 was most strongly associated with uric acid levels, with each copy of the minor allele associated with a decrease ..
  24. Jeannin G, Chiarelli N, Gaggiotti M, Ritelli M, Maiorca P, Quinzani S, et al. Recurrent exercise-induced acute renal failure in a young Pakistani man with severe renal hypouricemia and SLC2A9 compound heterozygosity. BMC Med Genet. 2014;15:3 pubmed publisher
    ..cause renal hypouricemia type 1 (RHUC1), whereas renal hypouricemia type 2 (RHUC2) is caused by mutations in the SLC2A9 gene...
  25. Facheris M, Hicks A, Minelli C, Hagenah J, Kostic V, Campbell S, et al. Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson's disease. J Mol Neurosci. 2011;43:246-50 pubmed publisher
    ..b>SLC2A9 has been indicated as the most effective of all uric acid transporters, and SLC2A9 variants have been shown to ..
  26. Urano W, Taniguchi A, Anzai N, Inoue E, Sekita C, Endou H, et al. Association between GLUT9 and gout in Japanese men. Ann Rheum Dis. 2010;69:932-3 pubmed publisher
  27. Dinour D, Gray N, Campbell S, Shu X, Sawyer L, Richardson W, et al. Homozygous SLC2A9 mutations cause severe renal hypouricemia. J Am Soc Nephrol. 2010;21:64-72 pubmed publisher
    ..We performed a genome-wide homozygosity screen and linkage analysis and identified the candidate gene SLC2A9, which encodes the glucose transporter 9 (GLUT9)...
  28. Sun X, Jiang F, Zhang R, Tang S, Chen M, Peng D, et al. Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population. Acta Pharmacol Sin. 2014;35:1421-7 pubmed publisher
    ..Fourteen single nucleotide polymorphisms (SNPs) mapped in or near 11 loci (PDZK1, GCKR, LRP2, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC17A3, SLC22A11, SLC22A12 and SF1) were genotyped in 2329 Chinese subjects in Shanghai...
  29. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009;5:e1000504 pubmed publisher
    ..Overall, the common variants associated with serum uric acid levels fall in the following nine regions: SLC2A9 (p = 5.2x10(-201)), ABCG2 (p = 3.1x10(-26)), SLC17A1 (p = 3.0x10(-14)), SLC22A11 (p = 6...
  30. Wallace C, Newhouse S, Braund P, Zhang F, Tobin M, Falchi M, et al. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet. 2008;82:139-49 pubmed publisher
    ..We discovered association between serum urate and SLC2A9, a glucose transporter (p = 2 x 10(-15)) and confirmed this in two independent cohorts, GRAPHIC study (p = 9 x 10(-..
  31. Polasek O, Gunjaca G, Kolcic I, Zgaga L, Dzijan S, Smolic R, et al. Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. Croat Med J. 2010;51:48-53 pubmed
    ..and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9...
  32. Evans S, Doblado M, Chi M, Corbett J, Moley K. Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells. Endocrinology. 2009;150:5302-10 pubmed publisher
    Facilitative glucose transporters (GLUTs) including GLUT9, accelerate the facilitative diffusion of glucose across the plasma membrane...
  33. Stiburkova B, Ichida K, Sebesta I. Novel homozygous insertion in SLC2A9 gene caused renal hypouricemia. Mol Genet Metab. 2011;102:430-5 pubmed publisher
    ..patients with renal hypouricemia caused by heterozygous defects and two families with homozygous mutations in the SLC2A9 gene have been recently described (OMIM #612076)...
  34. Zemunik T, Boban M, Lauc G, Jankovic S, Rotim K, Vatavuk Z, et al. Genome-wide association study of biochemical traits in Korcula Island, Croatia. Croat Med J. 2009;50:23-33 pubmed
    ..00 x 10(-5). Nine of SNPs implicated the role of SLC2A9 in uric acid regulation (P=4.10 x 10(-6)-2.58 x 10(-12)), as previously found in other populations...
  35. Vitart V, Rudan I, Hayward C, Gray N, Floyd J, Palmer C, et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet. 2008;40:437-42 pubmed publisher
    ..We have identified genetic variants within a transporter gene, SLC2A9, that explain 1.7-5...
  36. Caulfield M, Munroe P, O Neill D, Witkowska K, Charchar F, Doblado M, et al. SLC2A9 is a high-capacity urate transporter in humans. PLoS Med. 2008;5:e197 pubmed publisher
    ..Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout...
  37. Mobasheri A, Neama G, Bell S, Richardson S, Carter S. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Cell Biol Int. 2002;26:297-300 pubmed
    ..Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes...
  38. Augustin R, Carayannopoulos M, Dowd L, Phay J, Moley J, Moley K. Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. J Biol Chem. 2004;279:16229-36 pubmed
    The recently cloned human GLUT9 gene, which maps to chromosome 4p15.3-p16, consists of 12 exons coding for a 540-amino acid protein...
  39. Kawamura Y, Matsuo H, Chiba T, Nagamori S, Nakayama A, Inoue H, et al. Pathogenic GLUT9 mutations causing renal hypouricemia type 2 (RHUC2). Nucleosides Nucleotides Nucleic Acids. 2011;30:1105-11 pubmed publisher
    ..database of the Japan Maritime Self-Defense Force, we found two missense mutations (R198C and R380W) of GLUT9/SLC2A9 in hypouricemia patients...
  40. Yang B, Mo Z, Wu C, Yang H, Yang X, He Y, et al. A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population. BMC Med Genomics. 2014;7:10 pubmed publisher
    ..Current genome-wide association studies (GWASs) have identified a variety of genetic determinants of UA in Europeans; however, such studies in Asians, especially in Chinese populations remain limited...
  41. Cummings N, Dyer T, Kotea N, Kowlessur S, Chitson P, Zimmet P, et al. Genome-wide scan identifies a quantitative trait locus at 4p15.3 for serum urate. Eur J Hum Genet. 2010;18:1243-7 pubmed publisher
    ..We assessed associations between serum urate levels and 97 SNPs in a positional candidate gene, SLC2A9. A genome-wide scan identified a new region with evidence for linkage for serum urate at 4p15.3...
  42. Hollis Moffatt J, Gow P, Harrison A, Highton J, Jones P, Stamp L, et al. The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity. Arthritis Res Ther. 2011;13:R85 pubmed publisher
    The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9 confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a stronger role in tophaceous gout...
  43. Gunjaca G, Boban M, Pehlic M, Zemunik T, Budimir D, Kolcic I, et al. Predictive value of 8 genetic loci for serum uric acid concentration. Croat Med J. 2010;51:23-31 pubmed
    ..acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP)..
  44. Kimura T, Amonpatumrat S, Tsukada A, Fukutomi T, Jutabha P, Thammapratip T, et al. Increased expression of SLC2A9 decreases urate excretion from the kidney. Nucleosides Nucleotides Nucleic Acids. 2011;30:1295-301 pubmed publisher
    ..a urate-anion exchanger, URAT1, localized at the apical side and a voltage-driven urate efflux transporter, URATv1, expressed at the basolateral side of the renal proximal tubules...
  45. Li C, Chu N, Wang B, Wang J, Luan J, Han L, et al. Polymorphisms in the presumptive promoter region of the SLC2A9 gene are associated with gout in a Chinese male population. PLoS ONE. 2012;7:e24561 pubmed publisher
    ..several recent genome-wide association studies (GWAS) and follow-up studies have identified genetic variants of SLC2A9 associated with urate concentrations and susceptibility to gout...
  46. Doblado M, Moley K. Facilitative glucose transporter 9, a unique hexose and urate transporter. Am J Physiol Endocrinol Metab. 2009;297:E831-5 pubmed publisher
    b>GLUT9 is a novel, facilitative glucose transporter isoform that exists as two alternative splice variants encoding two proteins that differ in their NH(2)-terminal sequence (GLUT9a and GLUT9b)...
  47. Charles B, Shriner D, Doumatey A, Chen G, Zhou J, Huang H, et al. A genome-wide association study of serum uric acid in African Americans. BMC Med Genomics. 2011;4:17 pubmed publisher
    ..Four variants in the gene SLC2A9 achieved genome-wide significance for association with SUAL (p-values ranging from 8.88 × 10(-9) to 1...
  48. Bibee K, Augustin R, Gazit V, Moley K. The apical sorting signal for human GLUT9b resides in the N-terminus. Mol Cell Biochem. 2013;376:163-73 pubmed publisher
    ..We therefore believe the apical signal exists as an interplay between the final ten amino acids of the N-terminus and another motif within the protein such as the intracellular loop or other motifs within the N-terminus. ..
  49. Doege H, Bocianski A, Joost H, Schurmann A. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. Biochem J. 2000;350 Pt 3:771-6 pubmed
    The GLUT9 gene encodes a cDNA which exhibits significant sequence similarity with members of the glucose transporter (GLUT) family. The gene is located on chromosome 9q34 and consists of 10 exons separated by short introns...
  50. Tomioka N, Tamura Y, Takada T, Shibata S, Suzuki H, Uchida S, et al. Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain. Fluids Barriers CNS. 2016;13:22 pubmed
    ..and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1, ABCG2, and URAT1. Immunostaining for GLUT9 was observed in ependymal cells, neurons, and brain capillaries...
  51. Voruganti V, Franceschini N, Haack K, Laston S, Maccluer J, Umans J, et al. Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. Eur J Hum Genet. 2014;22:938-43 pubmed publisher
    ..The solute carrier protein 2 family, member 9 (SLC2A9) gene encodes a transporter that mediates urate flux across the renal proximal tubule...
  52. Xing S, Wang X, Miao Z, Zhang X, Zheng J, Yuan Y. Association of an Exon SNP of SLC2A9 Gene with Hyperuricemia Complicated with Type 2 Diabetes Mellitus in the Chinese Male Han Population. Cell Biochem Biophys. 2015;71:1335-9 pubmed publisher
    Several recent genome-wide association studies and following studies have identified that genetic variants of SLC2A9 are associated with hyperuricemia (HUA) and diabetes mellitus (DM)...
  53. Pyla R, Poulose N, Jun J, Segar L. Expression of conventional and novel glucose transporters, GLUT1, -9, -10, and -12, in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2013;304:C574-89 pubmed publisher
    ..In the proliferative phenotype, the relative abundance of key GLUT mRNAs was GLUT1 (?43%)>GLUT10 (?26%)>GLUT9 (?13%)>GLUT12 (?4%), whereas in the differentiated phenotype the relative abundance was GLUT10 (?28%)>GLUT1 (..
  54. Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, et al. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Mol Psychiatry. 2012;17:1316-27 pubmed publisher
    ..85 × 10(-7); 'AD+PvControls' P=1.11 × 10(-4)). SNPs upstream of SLC2A9 (rs6834555, P=3.0 × 10(-7)) and within VSNL1 (rs4038131, P=5...
  55. Itahana Y, Han R, Barbier S, Lei Z, Rozen S, Itahana K. The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. Oncogene. 2015;34:1799-810 pubmed publisher
    ..Here, we reported a first beneficial link between p53 and uric acid. We identified the uric acid transporter SLC2A9 (also known as GLUT9) as a direct p53 target gene and a key downstream effector in the reduction of reactive ..
  56. Takanaga H, Chaudhuri B, Frommer W. GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor. Biochim Biophys Acta. 2008;1778:1091-9 pubmed publisher
    ..inhibition of GLUT family members and show that GLUT1 is the major glucose transporter in HepG2 cells and that GLUT9 contributes as well, however to a lower extent...