SLC2A3

Summary

Gene Symbol: SLC2A3
Description: solute carrier family 2 member 3
Alias: GLUT3, solute carrier family 2, facilitated glucose transporter member 3, GLUT-3, glucose transporter type 3, brain, solute carrier family 2 (facilitated glucose transporter), member 3
Species: human
Products:     SLC2A3

Top Publications

  1. Fu Y, Maianu L, Melbert B, Garvey W. Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation. Blood Cells Mol Dis. 2004;32:182-90 pubmed
    ..Lymphocytes expressed GLUT 1 and GLUT 3 proteins, and cellular levels of both isoforms were augmented 3...
  2. Mobasheri A, Richardson S, Mobasheri R, Shakibaei M, Hoyland J. Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes. Histol Histopathol. 2005;20:1327-38 pubmed publisher
    ..alpha (HIF-1alpha) as an oxygen sensor and the hypoxia responsive facilitative glucose transporters, GLUT1 and GLUT3 as putative components of the glucose sensing apparatus in chondrocytes...
  3. Tsukioka M, Matsumoto Y, Noriyuki M, Yoshida C, Nobeyama H, Yoshida H, et al. Expression of glucose transporters in epithelial ovarian carcinoma: correlation with clinical characteristics and tumor angiogenesis. Oncol Rep. 2007;18:361-7 pubmed
    We immunohistochemically examined the expression of the glucose transporters (GLUT)1, GLUT3 and GLUT4, in 154 tumor samples of epithelial ovarian carcinoma...
  4. Krzeslak A, Wójcik Krowiranda K, Forma E, Jóźwiak P, Romanowicz H, Bienkiewicz A, et al. Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers. Pathol Oncol Res. 2012;18:721-8 pubmed publisher
    ..In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in ..
  5. Ha T, Her N, Lee M, Ryu B, Lee J, Han J, et al. Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription. Cancer Res. 2012;72:4097-109 pubmed publisher
    ..Consistently, CAV1 was shown to stimulate GLUT3 transcription via an HMGA1-binding site within the GLUT3 promoter...
  6. Novakovic B, Gordon L, Robinson W, Desoye G, Saffery R. Glucose as a fetal nutrient: dynamic regulation of several glucose transporter genes by DNA methylation in the human placenta across gestation. J Nutr Biochem. 2013;24:282-8 pubmed publisher
    ..family, and the expression of several of these has been shown in human placenta; however, aside from GLUT1 and GLUT3, little is known about the role of these proteins in placental function, fetal development and disease...
  7. Veal C, Reekie K, Lorentzen J, Gregersen P, Padyukov L, Brookes A. A 129-kb deletion on chromosome 12 confers substantial protection against rheumatoid arthritis, implicating the gene SLC2A3. Hum Mutat. 2014;35:248-56 pubmed publisher
    ..497 (P < 0.0002). The deletion variant lacks 129-kb of DNA containing SLC2A3, NANOGP1, and SLC2A14...
  8. Meneses A, Medina R, Kato S, Pinto M, Jaque M, Lizama I, et al. Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75. J Cell Physiol. 2008;214:110-6 pubmed
    ..Facilitative glucose transporter-1 (GLUT1) and -3 (GLUT3) have been previously shown to be present and regulated in breast cancer cells and are associated with poor ..
  9. Ayala F, Rocha R, Carvalho K, Carvalho A, da Cunha I, Lourenço S, et al. GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma. Molecules. 2010;15:2374-87 pubmed publisher
    ..A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. IHC results were evaluated according to the staining pattern and number of positive cells...

More Information

Publications120 found, 100 shown here

  1. Watanabe M, Naraba H, Sakyo T, Kitagawa T. DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells. Mol Cancer Res. 2010;8:1547-57 pubmed publisher
    ..Here, we report that DNA-damaging anticancer agents such as Adriamycin and etoposide suppressed the expression of GLUT3, but not GLUT1, in HeLa cells and a tumorigenic HeLa cell hybrid...
  2. Fei X, Qi M, Wu B, Song Y, Wang Y, Li T. MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression. FEBS Lett. 2012;586:392-7 pubmed publisher
    It has been reported that expression of glucose transporter member 3 (GLUT3) is up-regulated in bladder cancers. However, the regulating mechanism remains unknown...
  3. Ma Y, Batistel F, Xu T, Han L, Bucktrout R, Liang Y, et al. Phosphorylation of AKT serine/threonine kinase and abundance of milk protein synthesis gene networks in mammary tissue in response to supply of methionine in periparturient Holstein cows. J Dairy Sci. 2019;102:4264-4274 pubmed publisher
    ..glucose transport solute carrier family 2 member 3 (SLC2A1); glucose transport solute carrier family 2 member 3 (SLC2A3); and casein α-s1 (CSN1S1)...
  4. Cai M, Wang H, Li J, Zhang Y, Xin L, Li F, et al. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain Behav Immun. 2016;57:347-359 pubmed publisher
    ..obesity caused hyperglycemia and hyperlipidemia, and significantly promoted hippocampal glucose transporter 3 (GLUT3) and fatty acid transport protein 1 (FATP1) protein expression...
  5. Tyszka Czochara M, Bukowska Strakova K, Kocemba Pilarczyk K, Majka M. Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines. Nutrients. 2018;10: pubmed publisher
    ..the proteins involved in the &ldquo;Warburg effect&rdquo;, such as glucose transporters (GLUT1, GLUT3) and regulatory enzymes of glycolytic pathway Hexokinase 2 (HK2), 6-Phosphofructo-2-Kinase/Fructose-2,6-..
  6. Batistel F, Alharthi A, Wang L, Parys C, Pan Y, Cardoso F, et al. Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight. J Nutr. 2017;147:1640-1647 pubmed publisher
    ..members SLC3A2, SLC7A5, SLC38A1, and SLC38A10], glucose transport [SLC2A1, SLC2A3, and SLC2A4], and the mTOR pathway [mechanistic target of rapamycin and ribosomal protein S6 kinase B1] ..
  7. Liu Z, Patil I, Jiang T, Sancheti H, Walsh J, Stiles B, et al. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS ONE. 2015;10:e0128274 pubmed publisher
    ..b) a decreased expression and plasma membrane localization of the insulin-sensitive neuronal glucose transporters GLUT3/GLUT4; (c) a suppression of the ERK/CREB pathway, and (d) a substantial decrease in long-term potentiation in the ..
  8. Xu S, Wang G, Peng W, Xu Y, Zhang Y, Ge Y, et al. Corosolic acid isolated from Eriobotrya japonica leaves reduces glucose level in human hepatocellular carcinoma cells, zebrafish and rats. Sci Rep. 2019;9:4388 pubmed publisher
    ..and increased glucose consumption by regulating some key enzymes in carbon metabolism including GLUT1, GLUT2, GLUT3, LDHA, LDHB, GP, G6Pase, GYS1, and PFKFB3...
  9. Ibrahim B, Briski K. Role of dorsal vagal complex A2 noradrenergic neurons in hindbrain glucoprivic inhibition of the luteinizing hormone surge in the steroid-primed ovariectomized female rat: effects of 5-thioglucose on A2 functional biomarker and AMPK activity. Neuroscience. 2014;269:199-214 pubmed publisher
    ..Intriguingly, A2 AMPK activity was decreased in 5TG-treated rats, despite down-regulation of GLUT3 and no change in MCT2 protein expression...
  10. Liu W, Zhuo P, Li L, Jin H, Lin B, Zhang Y, et al. Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture. Free Radic Biol Med. 2017;112:174-190 pubmed publisher
    ..metabolism occurred in neurons or non-neuronal cells of the cortex and hippocampus in terms of the co-location of GLUT3/NeuN and GLUT1/GFAP...
  11. Liu C, Hu J, Tsai C, Yue M, Melrose H, Kanekiyo T, et al. Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. J Neurosci. 2015;35:5851-9 pubmed publisher
    ..LRP1 deficiency in neurons leads to impaired insulin signaling as well as reduced levels of glucose transporters GLUT3 and GLUT4. Consequently, glucose uptake is reduced...
  12. França M, Mesquita F, Lopes E, Pugliesi G, Van Hoeck V, Chiaratti M, et al. Modulation of periovulatory endocrine profiles in beef cows: consequences for endometrial glucose transporters and uterine fluid glucose levels. Domest Anim Endocrinol. 2015;50:83-90 pubmed publisher
    ..No differences (P > 0.05) were detected in gene expression patterns of SLC2A1, SLC2A3, SLC2A4, SLC2A5, SLC5A1, ATP1A2, ATP1B2, and SLC37A4...
  13. Joshi D, Sarkar D, Singh S. Decreased expression of orexin 1 receptor in adult mice testes during alloxan-induced diabetes mellitus perturbs testicular steroidogenesis and glucose homeostasis. Biochem Biophys Res Commun. 2017;490:1346-1354 pubmed publisher
    ..testicular steroidogenic enzymes, and expressions of various steroidogenic markers, OX1R, glucose transporter 3 (GLUT3) and Wilms' tumor gene (WT1) were downregulated in treated mice...
  14. Sarkar D, Singh S. Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring. Toxicology. 2017;386:103-119 pubmed publisher
    ..Testicular glucose and lactate concentrations were markedly reduced in these pups with down-regulation in GLUT3 and GLUT8 expressions and decreased LDH activity...
  15. Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa E, Almada L, Mahurkar Joshi S, et al. Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Gut. 2018;: pubmed publisher
    ..Further analysis of this phenomenon identified the glucose transporter SLC2A3 as a mediator of KMT2D-induced changes in cellular, metabolic and proliferative rates...
  16. Maynard D, Heijnen H, Gahl W, Gunay Aygun M. The α-granule proteome: novel proteins in normal and ghost granules in gray platelet syndrome. J Thromb Haemost. 2010;8:1786-96 pubmed publisher
    ..membrane-bound α-granule proteins were similar in normal platelets and GPS platelets, although P-selectin and Glut3 were slightly decreased, consistent with immunoelectron microscopy findings in resting platelets...
  17. Martins A, Moreira A, Sá R, Monteiro M, Sousa M, Carvalho R, et al. Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility?. Biochim Biophys Acta. 2015;1852:1824-32 pubmed publisher
    ..Leptin receptor was identified by qPCR and Western blot. Protein levels of glucose transporters (GLUT1, GLUT2 and GLUT3), phosphofructokinase, lactate dehydrogenase (LDH) and monocarboxylate transporter 4 (MCT4) were determined by ..
  18. Shrestha P, Briski K. Hindbrain lactate regulates preoptic gonadotropin-releasing hormone (GnRH) neuron GnRH-I protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat. Neuroscience. 2015;298:467-74 pubmed publisher
    ..Fos, estrogen receptor-beta (ER-β), phosphoAMPK (pAMPK)] and inhibition (dopamine-beta-hydroxylase, GLUT3, MCT2) of protein expression in these cells, responses that were normalized by insulin plus lactate treatment...
  19. Suh S, Kim Y, Goh T, Jeong D, Lee C, Jang J, et al. mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas. Yonsei Med J. 2018;59:746-753 pubmed publisher
    ..In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC without BRAF mutations...
  20. Fullston T, Shehadeh H, Sandeman L, Kang W, Wu L, Robker R, et al. Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cells. J Assist Reprod Genet. 2015;32:725-35 pubmed publisher
    ..embryos with delayed development and impaired quality, displayed increases in ovarian expression of Glut1, Glut3 and Glut4, and an increase in cumulus cell expression of Glut4...
  21. Zhao P, Xiao L, Peng J, Qian Y, Huang C. Exosomes derived from bone marrow mesenchymal stem cells improve osteoporosis through promoting osteoblast proliferation via MAPK pathway. Eur Rev Med Pharmacol Sci. 2018;22:3962-3970 pubmed publisher
    ..19 cells. Moreover, mRNA and protein expressions of GLUT3 in cells were increased, and the cell cycle was also promoted...
  22. Jeckel K, Boyarko A, Bouma G, Winger Q, Anthony R. Chorionic somatomammotropin impacts early fetal growth and placental gene expression. J Endocrinol. 2018;237:301-310 pubmed publisher
    ..reductions in IGF1 and IGF2 mRNA concentrations, along with reductions in SLC2A1 and SLC2A3 mRNA...
  23. Kwan S, King J, Yan J, Wang Z, Jiang X, Hutzler J, et al. Maternal Choline Supplementation Modulates Placental Nutrient Transport and Metabolism in Late Gestation of Mouse Pregnancy. J Nutr. 2017;147:2083-2092 pubmed publisher
    ..05). At E18.5, MCS upregulated GLUT3 protein abundance (+55%, P = 0...
  24. González Menéndez P, Hevia D, Mayo J, Sainz R. The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas?. Int J Cancer. 2017;: pubmed publisher
    ..In prostate cancer (PCa), androgens increase glucose uptake, upregulate GLUT transporters such as GLUT1 and GLUT3 and stimulate AMPK pathway, suggesting a possible connection between glycolytic and androgenic signaling...
  25. Saleh A, El Magd M. Beneficial effects of dietary silver nanoparticles and silver nitrate on broiler nutrition. Environ Sci Pollut Res Int. 2018;25:27031-27038 pubmed publisher
    ..in the following mRNA levels in muscle tissue: insulin-like growth factor-1 (IGF1), glucose transporters (Glut1, Glut3), citrate synthase (CS), and glutathione peroxidase (GPx), whereas the atrogin-1, fatty acid synthase (FAS), ..
  26. Zhang C, Skamagki M, Liu Z, Ananthanarayanan A, Zhao R, Li H, et al. Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells. Cell Rep. 2017;21:2058-2065 pubmed publisher
    ..young donors (Y-iPSCs), A-iPSCs show poor expression of the pluripotent stem cell-specific glucose transporter 3 (GLUT3) and impaired glucose uptake, making them unable to support the high glucose demands of glycolysis...
  27. Xie Y, Hu J, Wu H, Huang Z, Yan H, Shi Z. Bone marrow stem cells derived exosomes improve osteoporosis by promoting osteoblast proliferation and inhibiting cell apoptosis. Eur Rev Med Pharmacol Sci. 2019;23:1214-1220 pubmed publisher
    ..19 cells, and significantly increase the expression level of GLUT3. In addition, MSCs-derived exosomes remarkably downregulated apoptosis-related genes and decreased apoptosis in ..
  28. Kong L, Zhao Y, Zhou W, Yu H, Teng S, Guo Q, et al. Direct Neuronal Glucose Uptake Is Required for Contextual Fear Acquisition in the Dorsal Hippocampus. Front Mol Neurosci. 2017;10:388 pubmed publisher
    ..Furthermore, knockdown of GLUT3 by a lentivirus in the DH impaired the acquisition of CFC...
  29. Li R, Shen L, Yu X, Ma C, Huang Y. Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain. Life Sci. 2016;157:25-31 pubmed publisher
    ..The expression of sodium dependent vitamin C transporter 2 (SVCT2) and glucose transporter 3 (GLUT3) in dorsal root ganglion (DRG) were detected by quantitative real-time PCR, Western blot and immunohistochemistry...
  30. Proszkowiec Weglarz M, Dupont J, Rideau N, Gespach C, Simon J, Porter T. Insulin immuno-neutralization decreases food intake in chickens without altering hypothalamic transcripts involved in food intake and metabolism. Poult Sci. 2017;: pubmed publisher
    ..In addition, 5 h fasting increased levels of NPY, TAS1R1, DIO2, LEPR, GLUT1, GLUT3, GLUT8, and GCK mRNA. In contrast, AI had no impact on the levels of any selected mRNA...
  31. Oshima N, Onimaru H, Matsubara H, Uchida T, Watanabe A, Imakiire T, et al. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. 2017;344:74-88 pubmed publisher
    ..Low-level glucose-depolarized RVLM neurons exhibited the presence of glucose transporter 3 (GLUT3)...
  32. Wei M, Lu L, Sui W, Liu Y, Shi X, Lv L. Inhibition of GLUTs by WZB117 mediates apoptosis in blood-stage Plasmodium parasites by breaking redox balance. Biochem Biophys Res Commun. 2018;503:1154-1159 pubmed publisher
    ..site and inhibits the insulin-sensitive GLUT4 with greater potency than its inhibition of either GLUT1 or GLUT3. In our study, WZB117 effectively inhibit the growth of blood-stage parasites...
  33. Sanders E, Diehl S. Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma. Oncoscience. 2015;2:151-86 pubmed
    ..Genes that are highly over-expressed include ENO2, HK2, PFKP, SLC2A3, PDK1, and SLC16A1...
  34. Briffa J, Hosseini S, Tran M, Moritz K, Cuffe J, Wlodek M. Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters. Placenta. 2017;59:30-38 pubmed publisher
    ..Maternal stress decreased the expression of Slc2a1, Igf2, Slc38a2, Nr3c1, Slc2a3, Slc2a4, Nr3c2, Hsd11b2, Crhr1 and Ogt...
  35. Chang C, Chen Y, Chou S, Han C, Chen Y, Yang C, et al. Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and chemosensitivity. Cancer Res. 2014;74:6291-305 pubmed publisher
    ..Further, ROS(Low) cells frequently coexpressed CIC surface markers such as memGrp78 and Glut3. Exploiting flow cytometry to sort cells on the basis of their ROS level, we found that isolated ROS(Low) cells ..
  36. Bai S, Pan S, Zhang K, Ding X, Wang J, Zeng Q, et al. Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens. Environ Toxicol Pharmacol. 2017;54:191-198 pubmed publisher
    ..05) mRNA expression of glucose transporter (GLUT) 3 and GLUT9 in liver, and GLUT1, GLUT3, GLUT8, and GLUT9 in pectoralis major, but decreased (p<0...
  37. Alves M, Martins A, Moreira P, Carvalho R, Sousa M, Barros A, et al. Metabolic fingerprints in testicular biopsies from type 1 diabetic patients. Cell Tissue Res. 2015;362:431-40 pubmed publisher
    ..transporter 1 (GLUT1) and phosphofructokinase 1 (PFK1) were decreased in testes from diabetic men but only GLUT3 presented decreased mRNA and protein levels...
  38. Warzych E, Pawlak P, Pszczola M, Cieslak A, Madeja Z, Lechniak D. Interactions of bovine oocytes with follicular elements with respect to lipid metabolism. Anim Sci J. 2017;88:1491-1497 pubmed publisher
    ..staining), mRNA expression of seven genes in cumulus and granulosa cells (SCD, FADS2, ELOVL2, ELOVL5, GLUT1, GLUT3, GLUT8; real time polymerase chain reaction) and fatty acid (FA) composition in FF (gas chromatography)...
  39. Mobasheri A, Neama G, Bell S, Richardson S, Carter S. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Cell Biol Int. 2002;26:297-300 pubmed
    ..Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes...
  40. Cavin J, Couvelard A, Lebtahi R, Ducroc R, Arapis K, Voitellier E, et al. Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology. 2016;150:454-64.e9 pubmed publisher
    ..histologic analyses and measured levels of messenger RNAs encoding the sugar transporters SGLT1, GLUT1, GLUT2, GLUT3, GLUT4, and GLUT5. Glucose transport and consumption were assayed using ex vivo jejunal loops...
  41. Xu K, Guo S, Zhao T, Zhu H, Jiao H, Shi Q, et al. Transcriptome Analysis of HepG2 Cells Expressing ORF3 from Swine Hepatitis E Virus to Determine the Effects of ORF3 on Host Cells. Biomed Res Int. 2016;2016:1648030 pubmed publisher
    ..of CLDN6, YLPM1, APOC3, NLRP1, SCARA3, FGA, FGG, FGB, and FREM1 were upregulated, whereas the mRNA levels of SLC2A3, DKK1, BPIFB2, and PTGR1 were downregulated...
  42. Xing M, Chen X, Li X, Yang Y, Wang X, Cao X, et al. Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. Cell Biol Int. 2017;: pubmed publisher
    ..proliferation and induced GCs apoptosis by upregulating expression of BAX, meanwhile, downregulating expression of GLUT3, GLUT8, BCL-XL...
  43. De Zutter J, Levine K, Deng D, Carruthers A. Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis. J Biol Chem. 2013;288:20734-44 pubmed publisher
    ..GLUT1 and the neuronal glucose transporter GLUT3 do not form heterocomplexes in human embryonic kidney 293 (HEK293) cells as judged by co-immunoprecipitation ..
  44. Covarrubias Pinto A, Moll P, Solís Maldonado M, Acuña A, Riveros A, Miró M, et al. Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease. Free Radic Biol Med. 2015;89:1085-96 pubmed publisher
    ..Here, we observe a decreased expression of GLUT3 in STHdhQ111 cells (HD cells) and R6/2 mice (HD mice)...
  45. Lesch K, Selch S, Renner T, Jacob C, Nguyen T, Hahn T, et al. Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry. 2011;16:491-503 pubmed publisher
    ..2 (NDUFAF2), the brain-specific phosphodiesterase 4D isoform 6 (PDE4D6) and the neuronal glucose transporter 3 (SLC2A3). The gene encoding neuropeptide Y (NPY) was included in a ?3?Mb duplication on chromosome 7p15.2-15...
  46. Bergstrom U, Lindfors C, Svedberg M, Johansen J, Häggkvist J, Schalling M, et al. Reduced metabolism in the hypothalamus of the anorectic anx/anx mouse. J Endocrinol. 2017;233:15-24 pubmed publisher
    ..05) and GLUT4 (~60%; P?<?0.01) protein contents, whereas GLUT1 and GLUT3 were similar to that of wt hypothalamus...
  47. Agrawal S, Łuc M, Ziółkowski P, Agrawal A, Pielka E, Walaszek K, et al. Insulin-induced enhancement of MCF-7 breast cancer cell response to 5-fluorouracil and cyclophosphamide. Tumour Biol. 2017;39:1010428317702901 pubmed publisher
    ..We propose a model for insulin-induced sensitization process. Insulin acts as a sensitizer of cancer cells to cytotoxic therapy through various mechanisms opening a possibility for metronomic insulin-based treatments. ..
  48. Jansch C, Günther K, Waider J, Ziegler G, Forero A, Kollert S, et al. Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3. Stem Cell Res. 2018;28:136-140 pubmed publisher
    ..diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3)...
  49. Mlynarski E, Sheridan M, Xie M, Guo T, Racedo S, McDonald McGinn D, et al. Copy-Number Variation of the Glucose Transporter Gene SLC2A3 and Congenital Heart Defects in the 22q11.2 Deletion Syndrome. Am J Hum Genet. 2015;96:753-64 pubmed publisher
    ..Our analysis revealed that a duplication of SLC2A3 was the most frequent CNV identified in the first cohort...
  50. Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, et al. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015;526:391-6 pubmed publisher
    ..Using lipidic cubic phase crystallization and microfocus X-ray diffraction, we determined the structure of human GLUT3 in complex with D-glucose at 1.5 Ã… resolution in an outward-occluded conformation...
  51. Codreanu S, Hoeksema M, Slebos R, Zimmerman L, Rahman S, Li M, et al. Identification of Proteomic Features To Distinguish Benign Pulmonary Nodules from Lung Adenocarcinoma. J Proteome Res. 2017;16:3266-3276 pubmed publisher
    ..abundance of 10 proteins including ALOX5, ALOX5AP, CCL19, CILP1, COL5A2, ITGB2, ITGAX, PTPRE, S100A12, and SLC2A3 and significant ADC-specific abundance of CEACAM6, CRABP2, LAD1, PLOD2, and TMEM110-MUSTN1...
  52. Fidler T, Campbell R, Funari T, Dunne N, Balderas Angeles E, Middleton E, et al. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 2017;20:881-894 pubmed publisher
    ..Simultaneous deletion of glucose transporter (GLUT) 1 and GLUT3 (double knockout [DKO]) specifically in platelets completely abolished glucose uptake...
  53. Lloyd K, Ojelabi O, De Zutter J, Carruthers A. Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters. J Biol Chem. 2017;292:21035-21046 pubmed publisher
    ..lost in an oligomerization-deficient GLUT1 variant in which we substituted membrane helix 9 with the equivalent GLUT3 sequence. Moreover, Q282A eliminated cis-allostery in the oligomerization variant...
  54. Roeske D, Ludwig K, Neuhoff N, Becker J, Bartling J, Bruder J, et al. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. Mol Psychiatry. 2011;16:97-107 pubmed publisher
    ..devoid of any protein-coding genes; however, they both show significant association with mRNA-expression levels of SLC2A3 on chromosome 12, the predominant facilitative glucose transporter in neurons...
  55. Vaz C, Marques R, Alves M, Oliveira P, Cavaco J, Maia C, et al. Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes. J Cancer Res Clin Oncol. 2016;142:5-16 pubmed publisher
    ..of glucose and lactate were determined spectrophotometrically, and the expression of glucose transporters (GLUT1/GLUT3), phosphofructokinase 1, lactate dehydrogenase (LDH) and monocarboxylate transporter (MCT4) was analyzed by real-..
  56. Xu J, Lu C, Wang J, Zhang R, Qian X, Zhu H. Regulation of Human Trophoblast GLUT3 Glucose Transporter by Mammalian Target of Rapamycin Signaling. Int J Mol Sci. 2015;16:13815-28 pubmed publisher
    Glucose transporter isoform-3 (GLUT3), one of the primary placental facilitative glucose transporters responsible for basal glucose transport, has a crucial role in glucose transport and fetal growth during early pregnancy...
  57. Garcia M, Elsasser T, Qu Y, Zhu X, Moyes K. Glucose supplementation has minimal effects on blood neutrophil function and gene expression in vitro. J Dairy Sci. 2015;98:6139-50 pubmed publisher
    ..encoding for nuclear factor kappa B (NFKB1), IL-10 (IL10), IL1B, IL6, IL8, TNF-α (TNFA), glucose transporter 3 (SLC2A3), and the concentration of TNF-α in medium (147.3 vs. 72...
  58. Xu Q, Xiao F, Sun H, Shi X, Wang H, Yang Y, et al. Ptpmt1 induced by HIF-2α regulates the proliferation and glucose metabolism in erythroleukemia cells. Biochem Biophys Res Commun. 2016;471:459-65 pubmed publisher
    ..Furthermore, we demonstrated that Ptpmt1 inhibition reduces the Glut1 and Glut3 expression and decreases the glucose consumption in TF-1 cells...
  59. Dakal T, Kumar R, Ramotar D. Structural modeling of human organic cation transporters. Comput Biol Chem. 2017;68:153-163 pubmed publisher
    ..The modeled 3D structure of all hOCTs closely resemble to human SLC2A3 (GLUT3) transporter (PDB ID: 5c65) and displayed an outward-open confirmation and putative cyclic C1 protein ..
  60. Sperling S, Aung T, Martin S, Rohde V, Ninkovic M. Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells. Oncotarget. 2017;8:96697-96709 pubmed publisher
    ..riluzole on these cells were associated with an inhibition of a poor prognostic indicator: glucose transporter 3 (GLUT3). A decrease in GLUT3 is associated with a decrease in the p-Akt/HIF1? pathway...
  61. McCulloch L, van de Bunt M, Braun M, Frayn K, Clark A, Gloyn A. GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol Genet Metab. 2011;104:648-53 pubmed publisher
    ..the predominant glucose transporter (expression >10 fold higher that Slc2a1) in mouse islets whilst SLC2A1 and SLC2A3 predominate in both human islets and beta-cells (expression 2.8 and 2.7 fold higher than SLC2A2 respectively)...
  62. Whyard T, Waltzer W, Waltzer D, Romanov V. Metabolic alterations in bladder cancer: applications for cancer imaging. Exp Cell Res. 2016;341:77-83 pubmed publisher
    ..This effect might be partly explained by increased expression of glucose transporters GLUT1 and GLUT3 in transformed cells as compared to normal urothelium...
  63. Pliszka M, Oleszczak B, Szablewski L. Leptin at gender-specific concentrations does not affect glucose transport, expression of glucose transporters and leptin receptors in human lymphocytes. Endocrine. 2015;49:97-105 pubmed publisher
    ..Further studies are necessary to address the relationship between leptin, glucose transport and the lymphocytes' function in obesity. ..
  64. Niu L, Han D, Xu R, Han B, Zhou X, Wu H, et al. A High-sugar High-fat Diet Induced Metabolic Syndrome Shows some Symptoms of Alzheimer's Disease in Rats. J Nutr Health Aging. 2016;20:509-13 pubmed publisher
    ..Proteins associated with the insulin resistance signal pathway (JNK, PI-3K, AKT, GSK-3?, GLUT3) were evaluated using western blotting method...
  65. Chai Y, Yi J, Oh S, Kim Y, Yi K, Kim J, et al. Upregulation of SLC2 (GLUT) family genes is related to poor survival outcomes in papillary thyroid carcinoma: Analysis of data from The Cancer Genome Atlas. Surgery. 2017;161:188-194 pubmed publisher
    ..associated with age ≥45 years, extrathyroidal extension, higher TNM stage, and increased expression of SLC2A1, SLC2A3, and SLC2A14 mRNA...
  66. Villar P, Delgado R, Vergara C, Reyes J, Bacigalupo J. Energy Requirements of Odor Transduction in the Chemosensory Cilia of Olfactory Sensory Neurons Rely on Oxidative Phosphorylation and Glycolytic Processing of Extracellular Glucose. J Neurosci. 2017;37:5736-5743 pubmed publisher
    ..We measured millimolar glucose in rat mucus; we detected glucose transporter GLUT3 in rat and toad (Caudiverbera caudiverbera) OSN cilia, SC microvilli, and glycolytic enzymes in rat cilia...
  67. Brown K, Heller D, Zamudio S, Illsley N. Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation. Placenta. 2011;32:1041-9 pubmed publisher
    Conflicting information regarding expression of GLUT3 protein in the human placenta has been reported and the localization and pattern of expression of GLUT3 protein across gestation has not been clearly defined...
  68. Baumann M, Zamudio S, Illsley N. Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2007;293:C477-85 pubmed
    ..Reductions in oxygen tension resulted in dose-dependent increases in GLUT1 and GLUT3 expression...
  69. Coppieters K, Wiberg A, Amirian N, Kay T, Von Herrath M. Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals. Diabetes Metab Res Rev. 2011;27:746-54 pubmed publisher
    ..It remains questionable, however, whether these surviving cells can physiologically sense and respond to glucose stimuli...
  70. Shepherd P, Gould G, Colville C, McCoid S, Gibbs E, Kahn B. Distribution of GLUT3 glucose transporter protein in human tissues. Biochem Biophys Res Commun. 1992;188:149-54 pubmed
    To investigate the tissue distribution of the GLUT3 glucose transporter isoform in human tissue we produced affinity purified antibodies to the COOH terminus of the human GLUT3...
  71. Korgun E, Demir R, Sedlmayr P, Desoye G, Arikan G, Puerstner P, et al. Sustained hypoglycemia affects glucose transporter expression of human blood leukocytes. Blood Cells Mol Dis. 2002;28:152-9 pubmed
    ..05) under hypoglycemic conditions, which was paralleled by a reduction in GLUT1 and a rise in GLUT3. In monocytes, GLUT3 was elevated by 134% (P < 0...
  72. Cherian A, Briski K. Effects of adrenalectomy on neuronal substrate fuel transporter and energy transducer gene expression in hypothalamic and hindbrain metabolic monitoring sites. Neuroendocrinology. 2010;91:56-63 pubmed publisher
    ..Hagedorn insulin or vehicle injection, and evaluated by quantitative real-time RT-PCR for neuronal glucose (GLUT3, GLUT4), monocarboxylate (MCT2) transporter, GCK, and sulfonylurea receptor-1 (SUR1) mRNA content...
  73. Gao L, Lv C, Xu C, Li Y, Cui X, Gu H, et al. Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts. Endocrinology. 2012;153:1464-71 pubmed publisher
    ..GLUT1 and GLUT3 expressions in placenta were determined, and effects of CRH on GLUT1 and GLUT3 were examined...
  74. Flavahan W, Wu Q, Hitomi M, Rahim N, Kim Y, Sloan A, et al. Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat Neurosci. 2013;16:1373-82 pubmed publisher
    ..BTICs outcompete for glucose uptake by co-opting the high affinity neuronal glucose transporter, type 3 (Glut3, SLC2A3). BTICs preferentially express Glut3, and targeting Glut3 inhibits BTIC growth and tumorigenic potential...
  75. Fidler T, Middleton E, Rowley J, Boudreau L, Campbell R, Souvenir R, et al. Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol. 2017;37:1628-1639 pubmed publisher
    ..Here we evaluate the contribution of GLUT3 (glucose transporter 3) to platelet function to better understand glucose metabolism in platelets...
  76. Wang X, Hybiske K, Stephens R. Orchestration of the mammalian host cell glucose transporter proteins-1 and 3 by Chlamydia contributes to intracellular growth and infectivity. Pathog Dis. 2017;75: pubmed publisher
    ..that the expression of mammalian cell glucose transporter proteins 1 (GLUT1) and glucose transporter proteins 3 (GLUT3) were up-regulated during chlamydial infection...
  77. Fonteyne P, Casneuf V, Pauwels P, Van Damme N, Peeters M, Dierckx R, et al. Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. Histol Histopathol. 2009;24:971-7 pubmed publisher
    ..7; sd3.3) and GLUT1 (micro 5.5; sd: 5.3) were significantly higher than Hscores of GLUT9 (micro 2.2; sd 1.5) and GLUT3 (micro 3.2, sd: 2.5). Hscores of hexokinase I (micro : 8.3; sd: 4.3), II (micro 5.5, sd: 4.0) and III (I 1...
  78. Liu Y, Li Y, Tian R, Liu W, Fei Z, Long Q, et al. The expression and significance of HIF-1alpha and GLUT-3 in glioma. Brain Res. 2009;1304:149-54 pubmed publisher
    ..In conclusion, the expression of HIF-1alpha and GLUT-3 in glioma was correlated significantly with tumors' pathological grade, which can be taken as a pair of useful markers for predicting the biological behavior of glioma. ..
  79. Li L, Liu B, Håversen L, Lu E, Magnusson L, Ståhlman M, et al. The importance of GLUT3 for de novo lipogenesis in hypoxia-induced lipid loading of human macrophages. PLoS ONE. 2012;7:e42360 pubmed publisher
    ..Importantly, triglyceride synthesis from glucose was increased in hypoxic macrophages. GLUT3 was highly expressed in macrophage-rich and hypoxic regions of human carotid atherosclerotic plaques and in ..
  80. Vavaiya K, Briski K. Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol. J Mol Neurosci. 2008;34:121-9 pubmed
    ..Neuronal glucose (GLUT3, GLUT4) and monocarboxylate (MCT2) transporter genes are expressed in both sites, suggesting that glucose and ..
  81. Dimitriadis G, Maratou E, Boutati E, Kollias A, Tsegka K, Alevizaki M, et al. IGF-I increases the recruitment of GLUT4 and GLUT3 glucose transporters on cell surface in hyperthyroidism. Eur J Endocrinol. 2008;158:361-6 pubmed publisher
    ..GLUT isoforms were determined after staining the cells with specific antisera to GLUT3 and GLUT4...
  82. Liu Y, Liu F, Grundke Iqbal I, Iqbal K, Gong C. Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease. J Neurochem. 2009;111:242-9 pubmed publisher
    ..These results suggest that T2DM may contribute to the increased risk for AD by impairing brain glucose uptake/metabolism and, consequently, down-regulation of O-GlcNAcylation, which facilitates abnormal hyperphosphorylation of tau. ..
  83. Christensen D, Calder P, Houghton F. GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells. Sci Rep. 2015;5:17500 pubmed publisher
    ..In contrast to the glucose transporter GLUT1, GLUT3 was regulated by environmental oxygen and localised to hESC membranes...
  84. Schlößer H, Drebber U, Urbanski A, Haase S, Baltin C, Berlth F, et al. Glucose transporters 1, 3, 6, and 10 are expressed in gastric cancer and glucose transporter 3 is associated with UICC stage and survival. Gastric Cancer. 2017;20:83-91 pubmed publisher
    ..Glut-3 was associated with higher UICC stage and inferior prognosis. These findings are relevant to therapeutic approaches that target glucose metabolism as well as to imaging using radioactively labeled glucose. ..
  85. Hresko R, Kraft T, Quigley A, Carpenter E, Hruz P. Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids. J Biol Chem. 2016;291:17271-82 pubmed publisher
    ..effects of physiologically relevant phospholipids on glucose transport in liposomes containing purified GLUT4 and GLUT3. The anionic phospholipids, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, and phosphatidylinositol, ..
  86. Diógenes M, Guimarães A, Leme L, Maurício M, Dode M. Effect of prematuration and maturation with fibroblast growth factor 10 (FGF10) on in vitro development of bovine oocytes. Theriogenology. 2017;102:190-198 pubmed publisher
    ..At those time points, CCs were used for expression analysis of PTGS2, TNFAIP6, PTX3, HAS2, CASP8, CASP3, SLC2A1, SLC2A3 and FGFR2 genes...
  87. Crippa S, Ancey P, Vazquez J, Angelino P, Rougemont A, Guettier C, et al. Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma. EMBO Mol Med. 2017;9:1589-1604 pubmed publisher
    ..First, we demonstrated that glucose transporter GLUT3 is a direct TCF4/β-catenin target gene...
  88. Parente P, Coli A, Massi G, Mangoni A, Fabrizi M, Bigotti G. Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions. J Exp Clin Cancer Res. 2008;27:34 pubmed publisher
  89. Briski K, Cherian A, Genabai N, Vavaiya K. In situ coexpression of glucose and monocarboxylate transporter mRNAs in metabolic-sensitive caudal dorsal vagal complex catecholaminergic neurons: transcriptional reactivity to insulin-induced hypoglycemia and caudal hindbrain glucose or lactate rep. Neuroscience. 2009;164:1152-60 pubmed publisher
    ..The data show that IIH decreased MCT2, but elevated GLUT3, GLUT4, GCK, and SUR-1 transcripts in A2 neurons...
  90. Janzen C, Lei M, Cho J, Sullivan P, Shin B, Devaskar S. Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction. Placenta. 2013;34:1072-8 pubmed publisher
    ..To investigate placental expression of GLUT1, GLUT3 and GLUT4 and possible mechanisms of GLUT regulation in idiopathic IUGR...
  91. Warzych E, Pawlak P, Pszczola M, Cieslak A, Lechniak D. Prepubertal heifers versus cows-The differences in the follicular environment. Theriogenology. 2017;87:36-47 pubmed publisher
    ..involved in energy metabolism (fatty acids [FAs] metabolism-ELOVL2, ELOVL5, SCD, FADS2, glucose transport-GLUT1, GLUT3, GLUT8) in CC and GC as well as FA composition and glucose concentration in FF...
  92. Cheng H, Chang W, Hu Y, Hsieh B, Huang T, Chong I, et al. Arecoline Increases Glycolysis and Modulates pH Regulator Expression in HA22T/VGH Hepatoma Cells, Leading to Increase of Intracellular Ca2+, Reactive Oxygen Species, and Anoikis. J Cancer. 2017;8:3173-3182 pubmed publisher
    ..increased lactate and ATP production through induction of glycolytic genes, including glucose transporter 3 (Glut3), hexokinase 1 (HK1), hexokinase 2 (HK2), and pyruvate kinase (PK)...