Gene Symbol: SLC29A1
Description: solute carrier family 29 member 1 (Augustine blood group)
Alias: ENT1, equilibrative nucleoside transporter 1, equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter, nucleoside transporter, es-type, solute carrier family 29 (equilibrative nucleoside transporter), member 1, solute carrier family 29 (nucleoside transporters), member 1
Species: human
Products:     SLC29A1

Top Publications

  1. Lum P, Ngo L, Bakken A, Unadkat J. Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles. Cancer Chemother Pharmacol. 2000;45:273-8 pubmed
    ..Collectively, these findings suggest that the es transporter does not appear to be functionally variant in the human placenta, small intestine or erythrocytes. ..
  2. Sundaram M, Yao S, Ingram J, Berry Z, Abidi F, Cass C, et al. Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs. J Biol Chem. 2001;276:45270-5 pubmed
    ..Sequence analyses suggest that this membrane topology is common to all mammalian, insect, nematode, protozoan, yeast, and plant members of the ENT protein family. ..
  3. Sengupta D, Lum P, Lai Y, Shubochkina E, Bakken A, Schneider G, et al. A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine. Biochemistry. 2002;41:1512-9 pubmed
    ..This is the first identification and characterization of a critical amino acid residue of hENT1 that is important in both nucleoside transporter function and sensitivity to inhibition by NBMPR. ..
  4. Galmarini C, Thomas X, Calvo F, Rousselot P, El Jafaari A, Cros E, et al. Potential mechanisms of resistance to cytarabine in AML patients. Leuk Res. 2002;26:621-9 pubmed
    To determine whether the human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (dCK), cytoplasmic 5'-nucleotidase (5NT), cytidine deaminase (CDD), topoisomerase I (TOPO I) and topoisomerase II alpha (TOPO II) are ..
  5. Chow L, Lai R, Dabbagh L, Belch A, Young J, Cass C, et al. Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry. Mod Pathol. 2005;18:558-64 pubmed
    The human equilibrative nucleoside transporter 1 (hENT1) is a member of the equilibrative nucleoside transporter family that mediates cellular entry of gemcitabine, cytarabine, and fludarabine...
  6. Damaraju V, Elwi A, Hunter C, Carpenter P, Santos C, Barron G, et al. Localization of broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney. Am J Physiol Renal Physiol. 2007;293:F200-11 pubmed
  7. Santini D, Perrone G, Vincenzi B, Lai R, Cass C, Alloni R, et al. Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer. Ann Oncol. 2008;19:724-8 pubmed publisher
    ..The human equilibrative nucleoside transporter 1 (hENT1) is a ubiquitous protein and is the major means by which gemcitabine enters human cells...
  8. Marechal R, Bachet J, Mackey J, Dalban C, Demetter P, Graham K, et al. Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma. Gastroenterology. 2012;143:664-674.e6 pubmed publisher
    ..Key determinants of gemcitabine cytotoxicity include the activities of the human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (dCK), and ribonucleotide reductase subunit 1 (RRM1)...
  9. Eto K, Kawakami H, Kuwatani M, Kudo T, Abe Y, Kawahata S, et al. Human equilibrative nucleoside transporter 1 and Notch3 can predict gemcitabine effects in patients with unresectable pancreatic cancer. Br J Cancer. 2013;108:1488-94 pubmed publisher
    ..The expressions of human equilibrative nucleoside transporter 1 (hENT1), deoxycitidine kinase, ribonucleoside reductase 1, ribonucleoside reductase 2 and Notch3 ..

More Information

Publications118 found, 100 shown here

  1. Marechal R, Mackey J, Lai R, Demetter P, Peeters M, Polus M, et al. Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma. Clin Cancer Res. 2009;15:2913-9 pubmed publisher
    ..Human equilibrative nucleoside transporter 1 (hENT1) and human concentrative nucleoside transporter (hCNT) 1 and 3 are the major transporters ..
  2. Kim R, Tan A, Lai K, Jiang J, Wang Y, Rybicki L, et al. Prognostic roles of human equilibrative transporter 1 (hENT-1) and ribonucleoside reductase subunit M1 (RRM1) in resected pancreatic cancer. Cancer. 2011;117:3126-34 pubmed publisher
    ..Previous studies have suggested that in pancreatic cancer, human equilibrative nucleoside transporter 1 (hENT-1) and ribonucleoside reductase subunit M1 (RRM1) expression may have prognostic value as ..
  3. Murata Y, Hamada T, Kishiwada M, Ohsawa I, Mizuno S, Usui M, et al. Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy. J Hepatobiliary Pancreat Sci. 2012;19:413-25 pubmed publisher
    ..This biomarker could become a useful predictor of therapeutic effect for gemcitabine-based therapy in pancreatic cancer patients. ..
  4. Vieira C, Ferreirinha F, Magalhães Cardoso M, Silva I, Marques P, Correia de Sá P. Post-inflammatory Ileitis Induces Non-neuronal Purinergic Signaling Adjustments of Cholinergic Neurotransmission in the Myenteric Plexus. Front Pharmacol. 2017;8:811 pubmed publisher
    ..of Cav3 (T-type) channels existing in ICCs with mibefradil (3 ?M) or inhibition of the equilibrative nucleoside transporter 1 with dipyridamole (0.5 ?M), both decreased extracellular adenosine...
  5. Chen Y, Tian Y. Influence of miR-26b on hepatic cirrhosis and portal pressure in rats with cirrhotic portal hypertension by targeting hENT1 depending on RhoA/ROCK-1 pathway. Eur Rev Med Pharmacol Sci. 2019;23:1668-1673 pubmed publisher
    ..Western blotting was utilized to detect the protein levels of human equilibrative nucleoside transporter 1 (hENT1), ras homolog gene family, member A (RhoA) and Rho-associated coiled-coil-containing kinase ..
  6. Ruby C, O Connor K, Ayers Ringler J, Choi D. Adenosine and glutamate in neuroglial interaction: implications for circadian disorders and alcoholism. Adv Neurobiol. 2014;11:103-19 pubmed publisher
    ..Studies using mice lacking the equilibrative nucleoside transporter 1 have illuminated how adenosine functions through neuroglial interactions involving glutamate ..
  7. Fleck O, Fahnøe U, Løvschal K, Gasasira M, Marinova I, Kragelund B, et al. Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication. Genes (Basel). 2017;8: pubmed publisher
    ..salvage pathway in fission yeast by expressing the human nucleoside transporter human equilibrative nucleoside transporter 1 (hENT1) and the Drosophila deoxynucleoside kinase...
  8. Winstel V, Missiakas D, Schneewind O. Staphylococcus aureus targets the purine salvage pathway to kill phagocytes. Proc Natl Acad Sci U S A. 2018;115:6846-6851 pubmed publisher
    ..CRISPR-Cas9 mutagenesis to show that phagocyte intoxication involves uptake of dAdo via the human equilibrative nucleoside transporter 1, dAdo conversion to dAMP by deoxycytidine kinase and adenosine kinase, and signaling via ..
  9. Yoon K, Woo S, Hong E, Jung M, Park W, Bae K, et al. Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer. Oncology. 2015;89:345-50 pubmed publisher
    ..biomarkers for gemcitabine response include the activities of cytidine deaminase (CDA), human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (DCK), and ribonucleotide reductase M1 (RRM1)...
  10. Chen X, Yang Y, Berger I, Khalid U, Patel A, Cai J, et al. Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging. Oncotarget. 2017;8:24213-24223 pubmed publisher
    ..pathway activity, assessed by 3H-thymidine assays, thymidine kinase 1 (TK1) expression, and equilibrative nucleoside transporter 1 (ENT1) mobilization to the cell membrane, that peaked at 2hrs...
  11. Matyash M, Zabiegalov O, Wendt S, Matyash V, Kettenmann H. The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain. PLoS ONE. 2017;12:e0175012 pubmed publisher
    ..indicate that under normal physiological conditions, CD39 and CD73 nucleotidases together with equilibrative nucleoside transporter 1 (ENT1) control the fate of extracellular adenosine and thereby the ramification of microglial ..
  12. Gao Y, Yang F. [MiR-26b regulates invasion and migration of lung cancer cells through targeting hENT1 depending on RhoA/ROCK-1 pathway]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017;42:755-761 pubmed publisher
    ..b>equilibrative nucleoside transporter 1,hENT1)的相互作用;Transwell侵袭试验检测miR-26b的表达对肺癌细胞侵袭能力的..
  13. Phua L, Goh S, Tai D, Leow W, Alkaff S, Chan C, et al. Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. Cancer Chemother Pharmacol. 2018;81:277-289 pubmed publisher
    ..Particularly, tissue levels of lactic acid complemented transcript expression levels of human equilibrative nucleoside transporter 1 in distinguishing patients according to their overall survival...
  14. Reiner M, Akhmedov A, Stivala S, Keller S, Gaul D, Bonetti N, et al. Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Cardiovasc Res. 2017;113:61-69 pubmed publisher
    ..proteasomal degradation and TF activity, independently of the P2Y12 receptor and the equilibrative nucleoside transporter 1 (ENT1), an additional target of ticagrelor...
  15. Chen S, Wang Y, Zhang W, Dong M, Zhang J. Sclareolide enhances gemcitabine?induced cell death through mediating the NICD and Gli1 pathways in gemcitabine?resistant human pancreatic cancer. Mol Med Rep. 2017;15:1461-1470 pubmed publisher
    ..Epithelial to mesenchymal transition (EMT), human equilibrative nucleoside transporter 1 (hENT1) and ribonucleoside diphosphate reductase 1 (RRM1) were detected in the HPCCs and GR?HPCCs, ..
  16. Song A, Zhang Y, Han L, Yegutkin G, Liu H, Sun K, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8:14108 pubmed publisher
    ..Erythrocyte equilibrative nucleoside transporter 1 (eENT1) levels are reduced in humans at high altitude and in mice under hypoxia...
  17. Oba A, Ban D, Kirimura S, Akahoshi K, Mitsunori Y, Matsumura S, et al. Clinical application of the biomarkers for the selection of adjuvant chemotherapy in pancreatic ductal adenocarcinoma. J Hepatobiliary Pancreat Sci. 2016;23:480-8 pubmed publisher
    ..between treatment outcomes and the expressions of intratumoral human antigen R (HuR), human equilibrative nucleoside transporter 1 (hENT1), thymidylate synthetase (TS) and dihydropyrimidine dehydrogenase (DPD)...
  18. Guo Z, Hong S, Wang J, Rehan S, Liu W, Peng H, et al. Rapamycin-inspired macrocycles with new target specificity. Nat Chem. 2019;11:254-263 pubmed publisher
    ..Rapadocin is a potent, isoform-specific and FKBP-dependent inhibitor of the equilibrative nucleoside transporter 1 and is efficacious in an animal model of kidney ischaemia reperfusion injury...
  19. Moon S, Kim J, Sung J, Kang M, Kim S, Chang H, et al. p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines. Cancer Res Treat. 2015;47:501-8 pubmed publisher indicate gemcitabine sensitivity showed higher expression of PAK4 and lower expression of human equilibrative nucleoside transporter 1 (hENT1), a well-known predictive marker for gemcitabine activity, in the resistant cell lines...
  20. Ortega Paz L, Brugaletta S, Ariotti S, Akkerhuis K, Karagiannis A, Windecker S, et al. Adenosine and Ticagrelor Plasma Levels in Patients With and Without Ticagrelor-Related Dyspnea. Circulation. 2018;: pubmed publisher
  21. Shimakata T, Kamoshida S, Kawamura J, Ogane N, Kameda Y, Yanagita E, et al. Immunohistochemical expression profiles of solute carrier transporters in alpha-fetoprotein-producing gastric cancer. Histopathology. 2016;69:812-821 pubmed publisher
    ..SLC transporters examined were human equilibrative nucleoside transporter 1 (hENT1), organic anion transporter 2 (OAT2), organic cation transporter (OCT) 2, OCT6 and organic ..
  22. Klein D, Harding M, Crowther M, Cherrington N. Localization of nucleoside transporters in rat epididymis. J Biochem Mol Toxicol. 2017;31: pubmed publisher
    ..Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the ..
  23. Yan T, Li H, Wu J, Niu Q, Duan W, Han Q, et al. Astaxanthin inhibits gemcitabine-resistant human pancreatic cancer progression through EMT inhibition and gemcitabine resensitization. Oncol Lett. 2017;14:5400-5408 pubmed publisher
    ..ASX was identified to upregulate human equilibrative nucleoside transporter 1 (hENT1) and downregulate ribonucleoside diphosphate reductase (RRM) 1 and 2 to enhance gemcitabine-..
  24. Zhao X, Wang X, Sun W, Cheng K, Qin H, Han X, et al. Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment. Biomaterials. 2018;158:44-55 pubmed publisher
    ..This unique design of nanomedicine not only provides a universal platform to enhance chemosensitivity but also contributes to the precision design and personalized treatment in nanomedicine. ..
  25. Teng R. Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An Update. Clin Pharmacokinet. 2015;54:1125-38 pubmed publisher
    ..CYP2C19 and ABCB1 genotypes do not appear to influence ticagrelor pharmacodynamics. A summary of drug interactions is also presented. ..
  26. Kawamoto M, Umebayashi M, Tanaka H, Koya N, Nakagawa S, Kawabe K, et al. Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma. Anticancer Res. 2018;38:2739-2748 pubmed inducing mesenchymal-epithelial transition and enhancing chemosensitivity by increasing ENT1 (equilibrative nucleoside transporter 1) and reducing RRM1 (ribonucleotide reductase M1)...
  27. Nylander S, Schulz R. Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridines. Br J Pharmacol. 2016;173:1163-78 pubmed publisher
    ..ticagrelor is unique in having the only well-documented additional target of inhibition, the equilibrative nucleoside transporter 1. The current review will address the effects of P2Y12 receptor antagonists beyond platelets and ..
  28. Sumaya W, Storey R. Ticagrelor: Effects Beyond the P2Y12 Receptor. Interv Cardiol Clin. 2017;6:49-55 pubmed publisher
    ..This review considers the pleiotropic effects of ticagrelor and some of the possible mechanisms related to these effects. ..
  29. Alarcón S, Garrido W, Cappelli C, Suárez R, Oyarzun C, Quezada C, et al. Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy. Sci Rep. 2017;7:9439 pubmed publisher
    ..In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine...
  30. Silva I, Costa A, Moreira S, Ferreirinha F, Magalhães Cardoso M, Calejo I, et al. Inhibition of cholinergic neurotransmission by ?3-adrenoceptors depends on adenosine release and A1-receptor activation in human and rat urinary bladders. Am J Physiol Renal Physiol. 2017;313:F388-F403 pubmed publisher
    ..prevented isoprenaline-induced adenosine outflow from the rat detrusor, and this effect was mimicked by the ENT1 inhibitor, S-(4-nitrobenzyl)-6-thioinosine (NBTI, 30 µM)...
  31. Boß M, Newbatt Y, Gupta S, Collins I, Brüne B, Namgaladze D. AMPK-independent inhibition of human macrophage ER stress response by AICAR. Sci Rep. 2016;6:32111 pubmed publisher
    ..monophosphate (ZMP) while requiring intracellular uptake via the equilibrative nucleoside transporter (ENT) ENT1 or the concentrative nucleoside transporter (CNT) CNT3...
  32. Ma Z, Yang X, Jiang T, Bai M, Zheng C, Zeng S, et al. Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017;45:269-278 pubmed publisher
    ..Therefore, ETV uptake from maternal circulation to trophoblast cells was possibly transported by CNT2/3, ENT1/2, and OCTN2, whereas ETV efflux from trophoblast cells to fetal circulation was mediated by OCT3, and efflux from ..
  33. Kitao H, Morodomi Y, Niimi S, Kiniwa M, Shigeno K, Matsuoka K, et al. The antibodies against 5-bromo-2'-deoxyuridine specifically recognize trifluridine incorporated into DNA. Sci Rep. 2016;6:25286 pubmed publisher
    ..surrounding matrices, which consisted of fibroblasts with marginal expression of the nucleoside transporter genes SLC29A1 and SLC29A2...
  34. Miura T, Tachikawa M, Ohtsuka H, Fukase K, Nakayama S, Sakata N, et al. Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration. J Pharm Sci. 2017;106:2499-2508 pubmed publisher
    ..and cyp8b1, and drug transporters breast cancer resistance protein, multidrug resistance-associated protein 6, ent1, and oatp2b1; and (2) increases in glutathione biosynthetic enzymes and drug-metabolizing enzyme cyp3a11...
  35. Oliveros A, Cho C, Cui A, Choi S, Lindberg D, Hinton D, et al. Adenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation. Transl Psychiatry. 2017;7:e1095 pubmed publisher
    ..expression, and reduced ERK1 and ERK2 phosphorylation in the dHip of equilibrative nucleoside transporter type 1 (ENT1-/-) null mice, which displayed exacerbated impulsivity...
  36. Reiman T, Clarke M, Dabbagh L, Vsianska M, Coupland R, Belch A, et al. Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease. Leuk Lymphoma. 2002;43:1435-40 pubmed
    ..The most abundant and widely distributed transporter in human cells is human equilibrative nucleoside transporter 1 (hENT1)...
  37. Fukuchi Y, Furihata T, Hashizume M, Iikura M, Chiba K. Characterization of ribavirin uptake systems in human hepatocytes. J Hepatol. 2010;52:486-92 pubmed publisher
    ..b>Equilibrative nucleoside transporter 1 (ENT1)-mediated uptake was exclusively involved in ribavirin uptake in HH268 and HH283 and was ..
  38. Kim J, Karpyak V, Biernacka J, Nam H, Lee M, Preuss U, et al. Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. PLoS ONE. 2011;6:e16331 pubmed publisher
    ..In cultured cell and animal studies, type 1 equilibrative nucleoside transporter (ENT1, slc29a1), which regulates adenosine levels, is known to regulate ethanol sensitivity and preference...
  39. Plotnik D, Asher C, Chu S, Miyaoka R, Garwin G, Johnson B, et al. Levels of human equilibrative nucleoside transporter-1 are higher in proliferating regions of A549 tumor cells grown as tumor xenografts in vivo. Nucl Med Biol. 2012;39:1161-6 pubmed publisher
    ..identification of tumor chemosensitivity that is mediated by the human equilibrative nucleoside transporter-1 (ENT1)...
  40. Tavano F, Fontana A, Pellegrini F, Burbaci F, Rappa F, Cappello F, et al. Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients. J Transl Med. 2014;12:248 pubmed publisher
    ..hENT1, CHOP, MRP1 and DCK appear correlated to PDAC, and this interaction might influence disease behavior. ..
  41. Senyavina N, Gerasimenko T, Fomicheva K, Tonevitskaya S, Kaprin A. Localization and Expression of Nucleoside Transporters ENT1 and ENT2 in Polar Cells of Intestinal Epithelium. Bull Exp Biol Med. 2016;160:771-4 pubmed publisher
    ..Immunocytochemical staining revealed apical localization of ENT1 and integral expression of ENT2 in Caco-2 cells...
  42. Rosenbrier Ribeiro L, Ian Storer R. A semi-quantitative translational pharmacology analysis to understand the relationship between in vitro ENT1 inhibition and the clinical incidence of dyspnoea and bronchospasm. Toxicol Appl Pharmacol. 2017;317:41-50 pubmed publisher
    ..The equilibrative nucleoside transporter 1 (ENT1) terminates the action of adenosine by removal from the extracellular environment...
  43. Cusato J, Boglione L, De Nicolò A, Cardellino C, Carcieri C, Cariti G, et al. Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia. Pharmacogenomics. 2017;18:607-611 pubmed publisher
    ..We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. SNPs were evaluated through real-time PCR...
  44. Yabushita Y, Mori R, Taniguchi K, Matsuyama R, Kumamoto T, Sakamaki K, et al. Combined Analyses of hENT1, TS, and DPD Predict Outcomes of Borderline-resectable Pancreatic Cancer. Anticancer Res. 2017;37:2465-2476 pubmed
    ..The present study aimed to examine the relationship between intratumoral expression of human equilibrative nucleoside transporter 1 (hENT1), thymidylate synthase (TS), and dihydropyrimidine dehydrogenase (DPD) and the outcomes of ..
  45. Chen F, Szymanski E, Olivier K, Liu X, Tettelin H, Holland S, et al. Whole-Exome Sequencing Identifies the 6q12-q16 Linkage Region and a Candidate Gene, TTK, for Pulmonary Nontuberculous Mycobacterial Disease. Am J Respir Crit Care Med. 2017;196:1599-1604 pubmed publisher
    ..38). In addition, the genes MAP2K4, RCOR3, KRT83, IFNLR1, and SLC29A1 were associated with PNTM in our gene-level association analysis...
  46. Takagaki K, Katsuma S, Kaminishi Y, Horio T, Nakagawa S, Tanaka T, et al. Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells. J Biochem. 2004;136:733-40 pubmed
    ..The adenosine deaminase (ADA) gene was highly up-regulated in Ara-C-resistant cells, while equilibrative nucleoside transporter 1 (ENT1) and several cell-cycle-related genes were down-regulated...
  47. Zhao L, Zhao Y, Schwarz B, Mysliwietz J, Hartig R, Camaj P, et al. Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells. Int J Oncol. 2016;49:99-110 pubmed publisher
    ..In an orthotopic pancreatic cancer mouse model, both low and high dose verapamil was shown to substantially reduce L3.6plGres-SP cell tumor growth and metastasis, enhance tumor apoptosis, and reduce microvascular density. ..
  48. Peng M, Li Y, Zhang J, Wu Y, Yang X, Lei Y, et al. Vector-independent transmembrane transport of oligodeoxyribonucleotides involves p38 mitogen activated protein kinase phosphorylation. Sci Rep. 2017;7:13571 pubmed publisher
    ..44 µmol/L), distinguishing it from ENT1-4 and CNTs...
  49. Elwi A, Damaraju V, Kuzma M, Mowles D, Baldwin S, Young J, et al. Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3. Am J Physiol Renal Physiol. 2009;296:F1439-51 pubmed publisher
  50. Gilchrist S, Alcorn J. Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids. Fundam Clin Pharmacol. 2010;24:205-14 pubmed publisher
    ..increase in early lactation, which may remain elevated or decline with advancing lactation (Octn1, Cnt2, Cnt3, Ent1, Pept1, Pept2); (iii) constant but decreasing later in lactation (Octn3, Dmt1); (iv) increasing until mid-to-late ..
  51. Lane J, Martin T, McGuigan C, Mason M, Jiang W. The differential expression of hCNT1 and hENT1 i n breast cancer and the possible impact on breast cancer therapy. J Exp Ther Oncol. 2010;8:203-10 pubmed
    ..The level of expression of CNT1 was closely linked to the cell's responsiveness to chemotherapeutic treatments. ..
  52. Brito R, Pereira Figueiredo D, Socodato R, Paes de Carvalho R, Calaza K. Caffeine exposure alters adenosine system and neurochemical markers during retinal development. J Neurochem. 2016;138:557-70 pubmed publisher
    ..ENT1, Equilibrative nucleoside transporter 1.
  53. Takagi A, Nishimura T, Akashi T, Tomi M, Nakashima E. Contribution of equilibrative nucleoside transporter (ENT) 2 to fluorouracil transport in rat placental trophoblast cells. Drug Metab Pharmacokinet. 2017;32:151-156 pubmed publisher
    ..but 100 ?M NBMPR almost completely inhibited the saturable component, suggesting involvement of ENT2, rather than ENT1 in the transport...
  54. Ghoneim R, Kojovic D, Piquette Miller M. Impact of endotoxin on the expression of drug transporters in the placenta of HIV-1 transgenic (HIV-Tg) rats. Eur J Pharm Sci. 2017;102:94-102 pubmed publisher
    ..a pronounced downregulation in the hepatic expression of Abcb1a, Abcc2, Abcc4, Abcg2, Slco1a1, Slco1b2 and Slc29a1 in both HIV-Tg and WT rats; however, Abcb1b expression was increased in HIV but not WT rats...
  55. Farias M, San Martín R, Puebla C, Pearson J, Casado J, Pastor Anglada M, et al. Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol. 2006;208:451-60 pubmed
    ..We examined whether gestational diabetes-reduced adenosine transport results from lower hENT1 gene (SLC29A1) expression...
  56. Kim T, Ramesh V, Dworak M, Choi D, McCarley R, Kalinchuk A, et al. Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice. Neuroscience. 2015;303:211-9 pubmed publisher
    The type 1 equilibrative nucleoside transporter (ENT1) is implicated in regulating levels of extracellular adenosine ([AD]ex)...
  57. Ghoneim R, Piquette Miller M. Endotoxin-Mediated Downregulation of Hepatic Drug Transporters in HIV-1 Transgenic Rats. Drug Metab Dispos. 2016;44:709-19 pubmed publisher
    ..A significantly greater endotoxin- mediated downregulation of Ent1/Slc29a1 was seen in female HIV-Tg rats...
  58. Mangravite L, Xiao G, Giacomini K. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am J Physiol Renal Physiol. 2003;284:F902-10 pubmed
    ..These data suggest that hENT1 and hENT2 on the basolateral membrane function with concentrative nucleoside transporters on the apical membrane to mediate active reabsorption of nucleosides within the kidney. ..
  59. O Brien W, Ling H, Zhao Z, Lee C. New insights on the regulation of the adenine nucleotide pool of erythrocytes in mouse models. PLoS ONE. 2017;12:e0180948 pubmed publisher
    ..further evidence for the direct uptake of AMP by erythrocytes that is insensitive to dipyridamole, a blocker for ENT1. The uptake of AMP by the erythrocytes remained linear at the highest concentration tested, 10mM...
  60. Szkotak A, Ng A, Man S, Baldwin S, Cass C, Young J, et al. Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. J Membr Biol. 2003;192:169-79 pubmed
  61. Waidmann O, Pleli T, Dvorak K, Baehr C, Mondorf U, Plotz G, et al. Inhibition of the equilibrative nucleoside transporter 1 and activation of A2A adenosine receptors by 8-(4-chlorophenylthio)-modified cAMP analogs and their hydrolytic products. J Biol Chem. 2009;284:32256-63 pubmed publisher
    ..and 8-(4-chlorophenylthio)-2'-O-methyl-adenosine (8-pCPT-2'-O-methyl-ado)) inhibit the equilibrative nucleoside transporter 1 (ENT1)...
  62. Griffiths M, Beaumont N, Yao S, Sundaram M, Boumah C, Davies A, et al. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat Med. 1997;3:89-93 pubmed
  63. Zimmerman E, Huang M, Leisewitz A, Wang Y, Yang J, Graves L. Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells. FEBS Lett. 2009;583:425-9 pubmed publisher
    ..DNA sequencing revealed that these cells expressed an equilibrative nucleoside transporter 1 (ENT1) with a single missense mutation resulting in glycine to arginine replacement (G24R)...
  64. Oguri T, Achiwa H, Muramatsu H, Ozasa H, Sato S, Shimizu S, et al. The absence of human equilibrative nucleoside transporter 1 expression predicts nonresponse to gemcitabine-containing chemotherapy in non-small cell lung cancer. Cancer Lett. 2007;256:112-9 pubmed
    We report here the development of a polyclonal antibody for human equilibrative nucleoside transporter 1 (hENT1) and assess the expression of hENT1 in non-small cell lung cancer (NSCLC) patients who were treated with gemcitabine-..
  65. Oikonomopoulos G, Syrigos K, Saif M. Prognostic factors in pancreatic cancer. JOP. 2013;14:322-4 pubmed publisher
  66. Furihata T, Mizuguchi M, Suzuki Y, Matsumoto S, Kobayashi K, Chiba K. Identification of primary equilibrative nucleoside transporter 1 mRNA isoforms resulting from alternative promoter usage in human hepatocytes. Drug Metab Pharmacokinet. 2014;29:325-32 pubmed
    Human equilibrative nucleoside transporter 1 (hENT1) transports various nucleoside analogues into cells...
  67. Cusato J, Allegra S, De Nicolò A, Boglione L, Fatiguso G, Cariti G, et al. ABCB11 and ABCB1 gene polymorphisms impact on telaprevir pharmacokinetic at one month of therapy. Biomed Pharmacother. 2015;69:63-9 pubmed publisher
    ..was the evaluation of the influence of some single nucleotide polymorphisms (SNPs) of genes (ABCB1, SLC28A2/3, SLC29A1) involved in TLV and RBV transport and their correlation with plasma TLV drug exposure at 1 month of therapy...
  68. Panigrahi R, Dash S. ENT1 and treatment of viral diseases. Oncotarget. 2015;6:32281-2 pubmed publisher
  69. Bicket A, Mehrabi P, Naydenova Z, Wong V, Donaldson L, Stagljar I, et al. Novel regulation of equlibrative nucleoside transporter 1 (ENT1) by receptor-stimulated Ca2+-dependent calmodulin binding. Am J Physiol Cell Physiol. 2016;310:C808-20 pubmed publisher
    ..Here we report the identification of the calcium signaling transducer calmodulin (CaM) as an ENT1-interacting protein, via a conserved classic 1-5-10 motif in ENT1...
  70. Arora A, Deniskin R, Sosa Y, Nishtala S, Henrich P, Kumar T, et al. Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1. Mol Pharmacol. 2016;89:678-85 pubmed publisher
    ..They import purines via equilibrative nucleoside transporter 1 (ENT1) homologs...
  71. Ii H, Warraich S, Tenn N, Quinonez D, Holdsworth D, Hammond J, et al. Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis. Bone. 2016;90:37-49 pubmed publisher
    b>Equilibrative nucleoside transporter 1 (ENT1) mediates passage of adenosine across the plasma membrane...
  72. Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jirásková L, Greenwood S, et al. Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine. Placenta. 2017;60:86-92 pubmed publisher
    ..that the mechanisms of their transplacental passage might include equilibrative nucleoside transporters, ENT1 and/or ENT2...
  73. Sankar N, Machado J, Abdulla P, Hilliker A, Coe I. Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity. Nucleic Acids Res. 2002;30:4339-50 pubmed
    ..These data demonstrate that comparative sequence analyses should be combined with other approaches (such as genomic and proteomic analyses) to fully understand structure, function and evolution of protein families. ..
  74. Visser F, Baldwin S, Isaac R, Young J, Cass C. Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters. J Biol Chem. 2005;280:11025-34 pubmed
    ..This study demonstrated that the corresponding residues in TMs 1 and 11 of hENT1, hENT2, and CeENT1 are important for dipyridamole interactions and nucleoside transport. ..
  75. Galmarini C. Correlation of hENT1 expression and function with gemcitabine cytotoxicity in mantle cell lymphoma lines and clinical samples. Haematologica. 2006;91:866B pubmed
  76. Abdulla P, Coe I. Characterization and functional analysis of the promoter for the human equilibrative nucleoside transporter gene, hENT1. Nucleosides Nucleotides Nucleic Acids. 2007;26:99-110 pubmed
    ..Limited sequence similarity exists between the hENT1 and mouse ENT1 (mENT1) promoters suggesting conservation of ENT1 transcriptional regulators in mammals...
  77. Guallar J, Cano Soldado P, Aymerich I, Domingo J, Alegre M, Domingo P, et al. Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. Antivir Ther. 2007;12:853-63 pubmed
    ..Nucleoside transporter proteins (NTs) encoded by members of the SLC28 and SLC29 gene families contribute to nucleoside and nucleobase recycling but also modulate extracellular adenosine levels and thus adenosine-regulated metabolic targets...
  78. Carroll S, Stimpson H, Weinberg J, Toret C, Sun Y, Drubin D. Analysis of yeast endocytic site formation and maturation through a regulatory transition point. Mol Biol Cell. 2012;23:657-68 pubmed publisher
    ..The early-arriving proteins, as well as the later-arriving proteins Sla2p and Ent1/2p (homologues of Hip1R and epsins), were found to have longer lifetimes in CLC1-knockout yeast, which indicates ..
  79. Morote Garcia J, Kohler D, Roth J, Mirakaj V, Eldh T, Eltzschig H, et al. Repression of the equilibrative nucleoside transporters dampens inflammatory lung injury. Am J Respir Cell Mol Biol. 2013;49:296-305 pubmed publisher
    ..After inflammatory in vitro experiments, we observed a repression of ENT1 and ENT2 that was associated with an attenuation of extracellular adenosine uptake...
  80. Català A, Pastor Anglada M, Caviedes Cárdenas L, Malatesta R, Rives S, Vega García N, et al. FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016;7:49786-49799 pubmed publisher
    ..Cytarabine is transported into cells by Human Equilibrative Nucleoside Transporter-1 (hENT1, SLC29A1), but the mechanisms that regulate hENT1 in acute leukemia have been scarcely studied...
  81. Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I. Contribution of Equilibrative Nucleoside Transporter(s) to Intestinal Basolateral and Apical Transports of Anticancer Trifluridine. Biopharm Drug Dispos. 2017;: pubmed publisher
    ..An immunocytochemical analysis revealed that ENT1 was expressed at the basolateral and apical membranes of HIECs...
  82. Griffiths M, Yao S, Abidi F, Phillips S, Cass C, Young J, et al. Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem J. 1997;328 ( Pt 3):739-43 pubmed
    ..reported the isolation of a cDNA clone encoding a prototypic es-type transporter, hENT1 (human equilibrative nucleoside transporter 1), from human placenta...
  83. Casanello P, Torres A, Sanhueza F, Gonzalez M, Farias M, Gallardo V, et al. Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium. Circ Res. 2005;97:16-24 pubmed
    ..These results could be important in diseases where the fetus is exposed to intrauterine environments poor in oxygen, such as intrauterine growth restriction, or where adenosine transport is altered, such as gestational diabetes. ..
  84. Kost S, Sun C, Xiong W, Graham K, Cass C, Young J, et al. Behavioral effects of elevated expression of human equilibrative nucleoside transporter 1 in mice. Behav Brain Res. 2011;224:44-9 pubmed publisher
    ..Transgenic mice with neuronal expression of human equilibrative nucleoside transporter 1 (hENT1) have been generated (Parkinson et al., 2009 [7])...
  85. Wan H, Zhu J, Chen F, Xiao F, Huang H, Han X, et al. SLC29A1 single nucleotide polymorphisms as independent prognostic predictors for survival of patients with acute myeloid leukemia: an in vitro study. J Exp Clin Cancer Res. 2014;33:90 pubmed publisher
    ..Genotypes of rs9394992 and rs324148 for SLC29A1 in remission patients were significantly different from those in relapsed ones...
  86. Abraham A, Varatharajan S, Karathedath S, Philip C, Lakshmi K, Jayavelu A, et al. RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia. Pharmacogenomics. 2015;16:877-90 pubmed publisher
    ..RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA) was significantly ..
  87. Elebro J, Ben Dror L, Heby M, Nodin B, Jirström K, Eberhard J. Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer. Acta Oncol. 2016;55:286-96 pubmed publisher
    ..The most studied biomarker is human equilibrative nucleoside transporter 1 (hENT1), and the activating enzyme deoxycytidine kinase (dCK) has also been linked to treatment ..
  88. Yamada R, Mizuno S, Uchida K, Yoneda M, Kanayama K, Inoue H, et al. Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoin. Pancreas. 2016;45:761-71 pubmed publisher
    ..The assessment of hENT1 expression using EUS-FNAB samples before Gem-CRT provides important information on patients with PDAC who can benefit from curative-intent resection. ..
  89. Bicket A, Coe I. N-linked glycosylation of N48 is required for equilibrative nucleoside transporter 1 (ENT1) function. Biosci Rep. 2016;36: pubmed publisher
    Human equilibrative nucleoside transporter 1 (hENT1) transports nucleosides and nucleoside analogue drugs across cellular membranes and is necessary for the uptake of many anti-cancer, anti-parasitic and anti-viral drugs...
  90. Liu Y, Zuo T, Zhu X, Ahuja N, Fu T. Differential expression of hENT1 and hENT2 in colon cancer cell lines. Genet Mol Res. 2017;16: pubmed publisher
    Human equilibrative nucleoside transporters (hENT) 1 and 2, encoded by SLC29A1 and SLC29A2, permit the bidirectional passage of nucleoside analogues into cells and may correlate with clinical responses to chemotherapy in patients with ..
  91. Baloch K, Chen L, Memon A, Dexter L, Irving W, Ilyas M, et al. Equilibrative nucleoside transporter 1 expression in primary human hepatocytes is highly variable and determines uptake of ribavirin. Antivir Chem Chemother. 2017;25:2-10 pubmed publisher
    ..In vitro expression levels of equilibrative nucleoside transporter 1 (ENT1) has been shown to be a predictor of treatment response in patients receiving nucleoside-..
  92. Boswell Casteel R, Johnson J, Roe Zurz Z, Duggan K, Schmitz H, Hays F. Expression and purification of human and Saccharomyces cerevisiae equilibrative nucleoside transporters. Protein Expr Purif. 2018;142:68-74 pubmed publisher
    ..This article focuses on the expression and purification of human ENT1, human ENT2, and Saccharomyces cerevisiae ScENT1 using novel expression and purification strategies to isolate ..