Gene Symbol: SLC25A6
Description: solute carrier family 25 member 6
Alias: AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y, ADP/ATP translocase 3, ADP,ATP carrier protein, ADP,ATP carrier protein 3, ADP,ATP carrier protein, liver, ADP/ATP translocator of liver, adenine nucleotide translocator 3, solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Species: human
Products:     SLC25A6

Top Publications

  1. Jang J, Lee C. Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways. Cell Immunol. 2003;226:11-9 pubmed
    ..We have observed that IL-4 and IFN-gamma each up-regulates ANT3 in T cells both at mRNA and protein levels, while cotreatment of IL-4 and IFN-gamma counter-regulates ANT3 ..
  2. Chanturiya A, Basanez G, Schubert U, Henklein P, Yewdell J, Zimmerberg J. PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes. J Virol. 2004;78:6304-12 pubmed
  3. Jacotot E, Ravagnan L, Loeffler M, Ferri K, Vieira H, Zamzami N, et al. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med. 2000;191:33-46 pubmed
    ..membranes containing the purified PTPC or defined PTPC components such as the adenine nucleotide translocator (ANT) combined with Bax. Again, this effect is prevented by addition of recombinant Bcl-2...
  4. Romero Gavilan F, Araújo Gomes N, Cerqueira A, García Arnáez I, Martínez Ramos C, Azkargorta M, et al. Proteomic analysis of calcium-enriched sol-gel biomaterials. J Biol Inorg Chem. 2019;: pubmed publisher
    ..The attachment of pro- and anti-clotting proteins, such as THRB, ANT3, and PROC, increased significantly on the Ca-materials...
  5. Liu R, Jiang W, Walkey C, Chan W, Cohen Y. Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties. Nanoscale. 2015;7:9664-75 pubmed publisher
    ..850) with 11 PCFs. Considering the initial pool of 148 descriptors, the APOB, A1AT, ANT3, and PLMN serum proteins along with NP zeta potential were identified as most significant to correlating NP-cell ..
  6. Basei F, Meirelles G, Righetto G, Dos Santos Migueleti D, Smetana J, Kobarg J. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Proteome Sci. 2015;13:11 pubmed publisher
    ..Among the interacting partners, we found important proteins such as ANT3, Whirlin, PCNA, 14-3-3ε, SRSF1, SRSF2, SRPK1 and hNRNPs proteins...
  7. Winkler Moser J, Bakota E, Hwang H. Stability and Antioxidant Activity of Annatto (Bixa orellana L.) Tocotrienols During Frying and in Fried Tortilla Chips. J Food Sci. 2018;83:266-274 pubmed publisher
    Annatto tocotrienols (AnT3), which contain approximately 90% ?-tocotrienol (?-T3), were added to mid-oleic sunflower oil used for frying tortilla chips over 3 d...
  8. Mihasan M, Brandsch R. A predicted T4 secretion system and conserved DNA-repeats identified in a subset of related Arthrobacter plasmids. Microbiol Res. 2016;191:32-7 pubmed publisher
    ..The sequences end with 5'ATG.AAC3' which results in the amino terminal sequence methionine (M) and asparagine (N) for all predicted DprA, DUF4192 and ..
  9. Zhai Y, He Z, Kang Y, Yu H, Wang J, Du P, et al. Complete nucleotide sequence of pH11, an IncHI2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical Klebsiella pneumoniae isolate. Plasmid. 2016;86:26-31 pubmed publisher
    ..genes, including catA2, aac(6')-Ib, strB, strA, dfrA19, blaTEM-1, blaSHV-12, sul1, qacE delta 1, ereA, arr2, and aac3. The aac(6')-Ib is carried by a class I integron...

More Information


  1. Silva Marrero J, Sáez A, Caballero Solares A, Viegas I, Almajano M, Fernández F, et al. A transcriptomic approach to study the effect of long-term starvation and diet composition on the expression of mitochondrial oxidative phosphorylation genes in gilthead sea bream (Sparus aurata). BMC Genomics. 2017;18:768 pubmed publisher
    ..of coenzyme Q-binding protein (COQ10), cytochrome c oxidase subunit 6A2 (COX6A2) and ADP/ATP translocase 3 (SLC25A6) in the liver, and cytochrome c oxidase subunit 5B isoform 1 (COX5B1) in the liver and the skeletal muscle, are ..
  2. Lin C, Gu J, Wang H, Zhou J, Li J, Wang S, et al. Caspase-Dependent Apoptosis Induction via Viral Protein ORF4 of Porcine Circovirus 2 Binding to Mitochondrial Adenine Nucleotide Translocase 3. J Virol. 2018;92: pubmed publisher
    ..Subsequently, ORF4 protein colocalization with adenine nucleotide translocase 3 (ANT3) was observed using structured illumination microscopy...
  3. Lam H, Chan K, Ip M, Leung K, Lo N, Wong R, et al. Rapid Identification of Bacterial Antibiotic Resistance by qPCR in Infants with Gram-Negative Septicaemia: A Proof-of-Concept Study. Neonatology. 2017;111:145-152 pubmed publisher
    ..9, 96.4, 92.6 and 95.5%, respectively, for AAC3-2 [aac(3')-IIa/aacC3/aacC2, aac(3')-IIc/aacC2] to detect gentamicin resistance, and 59.3, 99.3, 94.1 and 92...
  4. Zhu Y, Lei Q, Li D, Zhang Y, Jiang X, Hu Z, et al. Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation. J Proteome Res. 2018;17:1509-1520 pubmed publisher
    ..Experiments using a model UFBP1-interacting protein ANT3 demonstrate that UFBP1 enhances the interaction between ANT3 and its E3 ligase and thus promotes its ubiquitination ..
  5. Funke S, Perumal N, Beck S, Gabel Scheurich S, Schmelter C, Teister J, et al. Glaucoma related Proteomic Alterations in Human Retina Samples. Sci Rep. 2016;6:29759 pubmed publisher
    ..Increase of stress related proteins and decrease of new glaucoma related candidates, ADP/ATP translocase 3 (ANT3), PC4 and SRFS1-interacting protein 1 (DFS70) and methyl-CpG-binding protein 2 (MeCp2) could be documented by MS...
  6. Schiebel K, Weiss B, Wohrle D, Rappold G. A human pseudoautosomal gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue on Xq is subject to X-inactivation. Nat Genet. 1993;3:82-7 pubmed
    ..This gene, ANT3, is located approximately 1,300 kilobases from the telomere, proximal to the pseudoautosomal gene CSF2RA, and ..
  7. Zamarin D, Garcia Sastre A, Xiao X, Wang R, Palese P. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog. 2005;1:e4 pubmed
    ..protein and showed that the viral protein uniquely interacts with the inner mitochondrial membrane adenine nucleotide translocator 3 and the outer mitochondrial membrane voltage-dependent anion channel 1, both of which are implicated ..
  8. Houldsworth J, Attardi G. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. Proc Natl Acad Sci U S A. 1988;85:377-81 pubmed
    ..The pattern of hybridization and the sizes of these mRNAs suggest a greater complexity of organization and expression of the ADP/ATP translocase genes in human cells than indicated by the analysis of the cDNA clones. ..
  9. Cui J, Yu M, Niu J, Yue Z, Xu Z. Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system. Biosci Rep. 2011;31:429-37 pubmed publisher
    ..showed that LRRK2 can interact with three components of the PTPC (permeability transition pore complex) including ANT (adenine nucleotide translocator), VDAC (voltage-dependent anion channel) and uMtCK [ubiquitous MtCK (mitochondrial ..
  10. Neckelmann N, Li K, Wade R, Shuster R, Wallace D. cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes. Proc Natl Acad Sci U S A. 1987;84:7580-4 pubmed
    ..This suggests that the mitochondrial DNA genes are highly prone to deleterious mutations. ..
  11. Jiao Y, Chen Y, Ma C, Qin J, Nguyen T, Liu D, et al. Phenylalanine as a nitrogen source induces root growth and nitrogen-use efficiency in Populus × canescens. Tree Physiol. 2017;:1-17 pubmed publisher
    ..Moreover, the transcript levels of putative Phe transporters ANT1 and ANT3 were upregulated, and the mRNA levels of NR, glutamine synthetase 2 (GS2), NADH-dependent glutamate synthase (NADH-..
  12. Eroshenko G, Nosov N, Krasnov Y, Oglodin Y, Kukleva L, Guseva N, et al. Yersinia pestis strains of ancient phylogenetic branch 0.ANT are widely spread in the high-mountain plague foci of Kyrgyzstan. PLoS ONE. 2017;12:e0187230 pubmed publisher
    ..It was found that forty two strains belong to 0.ANT2, 0.ANT3 and 0.ANT5 phylogenetic branches. From these, strains of 0.ANT2 and 0...
  13. Gavaldà Navarro A, Mampel T, Viñas O. Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status. Open Biol. 2016;6:150108 pubmed publisher
    ..Thus, cancer cells require both hANT2 and hANT3, depending on their proliferation status: hANT2 when proliferation rates are high, and hANT3 when proliferation slows. ..
  14. Martin I, Kim J, Lee B, Kang H, Xu J, Jia H, et al. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell. 2014;157:472-485 pubmed publisher
    ..These results reveal a novel mechanism of PD pathogenesis linked to elevated LRRK2 kinase activity and aberrant protein synthesis in vivo. ..
  15. Hu Z, Guo X, Yu Q, Qiu L, Li J, Ying K, et al. Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells. FEBS Lett. 2009;583:383-8 pubmed publisher
    ..We showed that CPT-induced apoptosis in QGY7703 cells and down-regulated the expression of ANT3. Using ANT3 knock-out and overexpression experiments, we provide further evidence that ANT3 plays a contributive ..
  16. Slim R, Levilliers J, Ludecke H, Claussen U, Nguyen V, Gough N, et al. A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation. Genomics. 1993;16:26-33 pubmed
    We report that the human ANT3 ADP/ATP translocase gene is a pseudoautosomal gene located proximal to the GM-CSF receptor alpha chain gene (CSF2RA). An ANT3-homologous locus, likely corresponding to a pseudogene, maps to chromosome 9...
  17. Zamora M, Granell M, Mampel T, Viñas O. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. FEBS Lett. 2004;563:155-60 pubmed
    ..Nothing is known, however, about the apoptotic activity of ANT3. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of ..
  18. Danishuddin M, Khan S, Khan A. Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. J Mol Model. 2010;16:535-41 pubmed publisher
    ..e. VDAC1 (outer membrane) and ANT3 (inner membrane)...
  19. Yang Z, Cheng W, Hong L, Chen W, Wang Y, Lin S, et al. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. Mol Biol Cell. 2007;18:4681-9 pubmed MCF-7 human breast cancer cells using retrovirus insertion-mediated random mutagenesis, we discovered that the ANT3 gene is involved in TNF-alpha-induced cell death in MCF-7 cells...
  20. Jang J, Lee C. IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. Cell Immunol. 2006;241:14-25 pubmed
    ..The IL-4-induced ANT3 expression is dependent on tyrosine kinase, NF-kappaB, PI3K/Akt, and Erk pathways...
  21. Kaukonen J, Juselius J, Tiranti V, Kyttälä A, Zeviani M, Comi G, et al. Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science. 2000;289:782-5 pubmed
    ..The analogous mutation in yeast caused a respiratory defect. These results indicate that ANT has a role in mtDNA maintenance and that a mitochondrial disease can be caused by a dominant mechanism.
  22. Verrier F, Mignotte B, Jan G, Brenner C. Study of PTPC composition during apoptosis for identification of viral protein target. Ann N Y Acad Sci. 2003;1010:126-42 pubmed
    ..anion channel (VDAC), PRAX-1, peripheral benzodiazepine receptor (PBR), adenine nucleotide translocator (ANT)], from cytosol (e.g., hexokinase II, glycerol kinase), from matrix [e.g...
  23. Majima E, Takeda M, Miki S, Shinohara Y, Terada H. Close location of the first loop to the third loop of the mitochondrial ADP/ATP carrier deduced from cross-linking catalyzed by copper-o-phenanthroline of the solubilized carrier with Triton X-100. J Biochem. 2002;131:461-8 pubmed
    ..It is suggested that the protruding first loop is located close to the third loop, which could be exposed to a certain degree. ..
  24. Komaki H, Fukazawa T, Houzen H, Yoshida K, Nonaka I, Goto Y. A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions. Ann Neurol. 2002;51:645-8 pubmed
    ..These findings support the pathogenesis of the adenine nucleotide translocator 1 gene mutation in human disease. ..
  25. Zenati K, Sahli F, Garcia V, Bakour S, Belhadi D, Rolain J, et al. Occurrence and clonal diversity of multidrug-resistant Klebsiella pneumoniae recovered from inanimate surfaces in Algerian hospital environment: First report of armA, qnrB and aac(6')-Ib-cr genes. J Glob Antimicrob Resist. 2017;10:148-153 pubmed publisher
    ..aac(6')-Ib), aminoglycoside nucleotidyl-transferase (aadA2) and aminoglycoside, phosphoryl-transferase (ant3″Ih-aac(6')-IId)...
  26. Cozens A, Runswick M, Walker J. DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol. 1989;206:261-80 pubmed
    ..The two DNA sequence also contain many short interspersed repetitive sequences including 11 Alu repeats, and a novel element about 236 base-pairs in length, which is repeated in a six-fold tandem array in intron B of the T2 gene. ..
  27. Napoli L, Bordoni A, Zeviani M, Hadjigeorgiou G, Sciacco M, Tiranti V, et al. A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family. Neurology. 2001;57:2295-8 pubmed
    ..The resulting leucine to proline substitution likely modifies the secondary structure of the ANT1 protein. ANT1 gene mutations may account for adPEO in families with different ethnic backgrounds...
  28. Mühlenbein N, Hofmann S, Rothbauer U, Bauer M. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. J Biol Chem. 2004;279:13540-6 pubmed
    ..During import, the small Tim complexes directly interact with human adenine nucleotide translocator (ANT) in transit in a metal-dependent manner...
  29. Maldonado E, Dehart D, Patnaik J, Klatt S, Gooz M, Lemasters J. ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem. 2016;291:19642-50 pubmed publisher
    ..However in cancer cells, BA, CAT, and knockdown of the major ANT isoforms, ANT2 and ANT3, did not collapse ?? after respiratory inhibition...
  30. Guo X, Huang Y, Qi Y, Liu Z, Ma Y, Shao Y, et al. Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells. Arch Virol. 2015;160:2483-90 pubmed publisher
    ..that a cellular gene, solute carrier family 25, member 6 (SLC25A6), which is also designated adenine nucleotide translocator 3 (ANT3), was identified as a candidate target of hcmv-miR-UL36-5p by hybrid PCR...
  31. Ahuja N, Schwer B, Carobbio S, Waltregny D, North B, Castronovo V, et al. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007;282:33583-92 pubmed
    ..that coimmunoprecipitate with SIRT4 identified insulindegrading enzyme and the ADP/ATP carrier proteins, ANT2 and ANT3. SIRT4 exhibits no histone deacetylase activity but functions as an efficient ADP-ribosyltransferase on histones ..
  32. De Marcos Lousa C, Trezeguet V, Dianoux A, Brandolin G, Lauquin G. The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae. Biochemistry. 2002;41:14412-20 pubmed
    ..These results point to the importance of the N-terminal region of HAnc1p for its biogenesis and transport activity in yeast mitochondria. ..
  33. Zamora M, Ortega J, Alaña L, Viñas O, Mampel T. Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid. Exp Cell Res. 2006;312:1813-9 pubmed
    ..Our results revealed that ANT1 and ANT3 over-expressing HeLa cells increased their atRA sensitivity...
  34. Deniaud A, Brenner C, Kroemer G. Mitochondrial membrane permeabilization by HIV-1 Vpr. Mitochondrion. 2004;4:223-33 pubmed
    ..Vpr cooperates with the adenine nucleotide translocator (ANT) to form large conductance channels and to trigger all the hallmarks of mitochondrial membrane permeabilization (..