Gene Symbol: SLC25A5
Description: solute carrier family 25 member 5
Alias: 2F1, AAC2, ANT2, ADP/ATP translocase 2, ADP,ATP carrier protein, fibroblast isoform, adenine nucleotide translocator 2 (fibroblast), solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Species: human
Products:     SLC25A5

Top Publications

  1. Houldsworth J, Attardi G. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. Proc Natl Acad Sci U S A. 1988;85:377-81 pubmed
    ..The pattern of hybridization and the sizes of these mRNAs suggest a greater complexity of organization and expression of the ADP/ATP translocase genes in human cells than indicated by the analysis of the cDNA clones. ..
  2. Ahuja N, Schwer B, Carobbio S, Waltregny D, North B, Castronovo V, et al. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007;282:33583-92 pubmed
    ..proteins that coimmunoprecipitate with SIRT4 identified insulindegrading enzyme and the ADP/ATP carrier proteins, ANT2 and ANT3...
  3. Jang J, Choi Y, Jeon Y, Kim C. Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. Breast Cancer Res. 2008;10:R11 pubmed publisher
    Adenine nucleotide translocator (ANT) 2 is highly expressed in proliferative cells, and ANT2 induction in cancer cells is known to be directly associated with glycolytic metabolisms and carcinogenesis...
  4. Chevrollier A, Loiseau D, Gautier F, Malthiery Y, Stepien G. ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells. Mol Carcinog. 2005;42:1-8 pubmed
    ..e., proliferation or quiescence. Our study links the constitutive glycolytic activity and ANT2 expression levels of transformed cells with the loss of cell-cycle control after oxygen deprivation...
  5. Doerner A, Pauschinger M, Badorff A, Noutsias M, Giessen S, Schulze K, et al. Tissue-specific transcription pattern of the adenine nucleotide translocase isoforms in humans. FEBS Lett. 1997;414:258-62 pubmed
    Three adenine nucleotide translocase isoforms (ANT1, ANT2 and ANT3) are coded by different genes. The relative amounts of the three ANT isoform mRNAs were determined in detail in various human tissues...
  6. Jang J, Jeon Y, Choi Y, Kim C. Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression. Mol Cancer. 2010;9:262 pubmed publisher
    ..We previously reported that the suppression of adenine nucleotide translocase-2 (ANT2) by short-hairpin RNA (shRNA) induces apoptosis of breast cancer cells, which frequently express high levels of ..
  7. Luciakova K, Barath P, Poliakova D, Persson A, Nelson B. Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1. J Biol Chem. 2003;278:30624-33 pubmed
    Adenine nucleotide translocase-2 (ANT2) catalyzes the exchange of ATP for ADP across the mitochondrial membrane, thus playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth...
  8. Chevrollier A, Loiseau D, Reynier P, Stepien G. Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism. Biochim Biophys Acta. 2011;1807:562-7 pubmed publisher
    ..Thus, ANT1 is specific to muscle and brain tissues; ANT2 occurs mainly in proliferative, undifferentiated cells; ANT3 is ubiquitous; and ANT4 is found in germ cells...
  9. Boraldi F, Lofaro F, Romano O, Grilli A, Losi L, Moscarelli P, et al. Exome sequencing and bioinformatic approaches reveals rare sequence variants involved in cell signalling and elastic fibre homeostasis: new evidence in the development of ectopic calcification. Cell Signal. 2019;59:131-140 pubmed publisher
    ..Eventually, the presence of multiple rare sequence variants in the Solute Carrier Family 25 Member 5 (SLC25A5) gene is suggestive of the role of this gene as a key factor linking mitochondria metabolism, ADP/ATP ratio and ..

More Information


  1. Jang J, Jeon Y, Kim C. Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells. BMC Cancer. 2010;10:391 pubmed publisher
    ..In this study, we examined the question of whether or not adenine nucleotide translocase 2 (ANT2) short hairpin RNA (shRNA)-mediated down-regulation of HER2/neu and inhibitory effects on the PI3K/Akt signaling ..
  2. Li L, Carratt S, Hartog M, Kovalchik N, Jia K, Wang Y, et al. Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice. Environ Health Perspect. 2017;125:067004 pubmed publisher
    ..were determined for lung and nasal olfactory mucosa (OM) from Cyp2abfgs-null, CYP2A13-humanized, and CYP2A13/2F1-humanized mice...
  3. Lee C, Kim M, Lee H, Paeng J, Park Y, Oh S, et al. Adenine Nucleotide Translocase 2 as an Enzyme Related to [18F] FDG Accumulation in Various Cancers. Mol Imaging Biol. 2018;: pubmed publisher
    ..We investigated the involvement of adenine nucleotide translocase 2 (ANT2), which catalyzes ADP/ATP exchange at the mitochondrial inner membrane, in [18F] FDG accumulation...
  4. Mrazkova B, Dzijak R, Imrichova T, Kyjacova L, Barath P, Dzubak P, et al. Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Aging (Albany NY). 2018;10:434-462 pubmed publisher
    ..lack of L1CAM induction in RAS-induced senescence); and 4) induced upon downregulation of growth-associated gene ANT2, growth in low-glucose medium or inhibition of the mevalonate pathway...
  5. Lundberg K, Fritz Y, Johnston A, Foster A, Baliwag J, Gudjonsson J, et al. Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans. Mol Cell Proteomics. 2015;14:109-19 pubmed publisher
    ..0 including: stefin A1 (average fold change of 342.4 and an average p = 0.0082; cystatin A, human ortholog); slc25a5 (average fold change of 46.2 and an average p = 0.0318); serpinb3b (average fold change of 35...
  6. Zhao J, Mu L, Qi Y, Hu Y, Liu H, Dai S. A phase-transfer assisted solvo-thermal strategy for low-temperature synthesis of Na3(VO1-xPO4)2F1+2x cathodes for sodium-ion batteries. Chem Commun (Camb). 2015;51:7160-3 pubmed publisher
    ..that a series of high-performance cathode materials, sodium vanadium polyanionic compounds, Na3(VO1-xPO4)2F1+2x (x = 0, 0...
  7. Liu Y, Wang X, Chen X. Misfolding of mutant adenine nucleotide translocase in yeast supports a novel mechanism of Ant1-induced muscle diseases. Mol Biol Cell. 2015;26:1985-94 pubmed publisher
    ..Here we show that equivalent mutations in the yeast Aac2 protein cause protein misfolding...
  8. Hubackova S, Davidova E, Rohlenova K, Stursa J, Werner L, Andera L, et al. Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2. Cell Death Differ. 2019;26:276-290 pubmed publisher
    ..of senescent cells to MitoTam is linked to a very low expression level of adenine nucleotide translocase-2 (ANT2), inherent to the senescent phenotype...
  9. Liu Z, Li L, Wu H, Hu J, Ma J, Zhang Q, et al. Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. Drug Metab Dispos. 2015;43:208-16 pubmed publisher was to further characterize the expression and function of human CYP2B6 in a recently generated CYP2A13/2B6/2F1-transgenic (TG) mouse model, in which CYP2B6 is expressed selectively in the liver...
  10. Todisco S, Di Noia M, Onofrio A, Parisi G, Punzi G, Redavid G, et al. Identification of new highly selective inhibitors of the human ADP/ATP carriers by molecular docking and in vitro transport assays. Biochem Pharmacol. 2016;100:112-32 pubmed publisher
    ..and poisoning at physiological level, we estimated here for the first time their affinity for the human recombinant AAC2 by in vitro transport assays. We found that the inhibition constants of CATR and BKA are 4 nM and 2...
  11. Kriegel A, Terhune S, Greene A, Noon K, Pereckas M, Liang M. Isomer-specific effect of microRNA miR-29b on nuclear morphology. J Biol Chem. 2018;293:14080-14088 pubmed publisher
    ..One of these proteins, ADP/ATP translocase 2 (ANT2), known to be involved in mitotic spindle formation, colocalized with miR-29b in perinuclear clusters independently ..
  12. da Silva R, Gomes A, Franco P, Pereira A, Milian I, Ribeiro M, et al. Enrofloxacin and Toltrazuril Are Able to Reduce Toxoplasma gondii Growth in Human BeWo Trophoblastic Cells and Villous Explants from Human Third Trimester Pregnancy. Front Cell Infect Microbiol. 2017;7:340 pubmed publisher
    ..Next, BeWo cells were infected by T. gondii (2F1 clone or the ME49 strain), whereas villous samples were only infected by the 2F1 clone...
  13. Crichton P, Lee Y, Ruprecht J, Cerson E, Thangaratnarajah C, King M, et al. Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers. J Biol Chem. 2015;290:8206-17 pubmed publisher
    ..Trends in the thermostability of yeast ADP/ATP carrier AAC2 and ovine uncoupling protein UCP1 allow optimal conditions for stability in detergents to be established but also ..
  14. Blakley B, Garcia C, da Sliva S, Florêncio V, Nagy J. Elevated auditory brainstem response thresholds in mice with Connexin36 gene ablation. Acta Otolaryngol. 2015;135:814-8 pubmed publisher
    ..DPOAEs were delivered for seven frequency pairs to assess cochlear function. The magnitudes of the 2f1-f2 distortion products were not different between Cx36 knockout and wild-type mice, suggesting similar cochlear ..
  15. Mora E, Cobo Cuan A, Macías Escrivá F, Kössl M. Unexpected dynamic up-tuning of auditory organs in day-flying moths. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015;201:657-66 pubmed publisher
    ..The level of the dominant distortion product (i.e. 2f1-f2) varied as a function of time by as much as 45 dB during ongoing acoustic stimulation, showing a systematic ..
  16. Wen H, Bowling T, Meaud J. Investigation of the 2f1-f2 and 2f2-f1 distortion product otoacoustic emissions using a computational model of the gerbil ear. Hear Res. 2018;365:127-140 pubmed publisher
    ..As in experiments in the gerbil, the group delay of the reflection component of the DPOAE is between 1× and 2× the forward group delay, which is consistent with the propagation of DP towards the stapes as slow reverse waves. ..
  17. Anderson S, Sherman E, Weiss D, Rather P. Aminoglycoside Heteroresistance in Acinetobacter baumannii AB5075. mSphere. 2018;3: pubmed publisher
    ..baumannii We define the mechanistic basis for heteroresistance, where the aadB(ant2″)Ia gene encoding an aminoglycoside adenylyltransferase becomes highly amplified in a RecA-dependent manner...
  18. Pan S, Xue D, Li Z, Zhou Z, He Z, Yang Y, et al. Computational Identification of the Paralogs and Orthologs of Human Cytochrome P450 Superfamily and the Implication in Drug Discovery. Int J Mol Sci. 2016;17: pubmed publisher
    ..For example, the paralogs of CYP2A6 include CYP2A7, 2A13, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 2F1, 2J2, 2R1, 2S1, 2U1, and 2W1; CYP11A1 has 6 paralogs including CYP11B1, 11B2, 24A1, 27A1, 27B1, and 27C1; CYP51A1 ..
  19. Indo H, Tomiyoshi T, Suenaga S, Tomita K, Suzuki H, Masuda D, et al. MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1. J Clin Biochem Nutr. 2015;57:98-104 pubmed publisher
    ..expression of proapoptotic APAF1 and downregulation of proapoptotic CYTC, VDAC2, VDAC3, CASP8, AIF, ANT1, and ANT2, as well as an increase in expression of antiapoptotic BCL2. There was also a decrease in MnSOD expression with 0...
  20. Li L, Zhang Q, Ding X. A CYP2B6-humanized mouse model and its potential applications. Drug Metab Pharmacokinet. 2018;33:2-8 pubmed publisher
    ..A CYP2B6-humanized mouse model (CYP2A13/2B6/2F1-transgenic/Cyp2abfgs-null), which expresses human CYP2B6 in the liver, and human CYP2A13 and CYP2F1 in the ..
  21. Li Y, Rao X, MATTOX W, Amos C, Liu B. RNA-Seq Analysis of Differential Splice Junction Usage and Intron Retentions by DEXSeq. PLoS ONE. 2015;10:e0136653 pubmed publisher
    ..The analysis confirmed previous findings on the alternative splicing of the trol and Ant2 (sesB) genes in the CG8144 (ps)-depletion experiment and identified some new alternative splicing events in other ..
  22. Watanabe M, Iizumi Y, Sukeno M, Iizuka Ohashi M, Sowa Y, Sakai T. The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2. Oncogenesis. 2017;6:e311 pubmed publisher
    ..As a consequence, we found that adenine nucleotide translocase 2 (ANT2), the inner mitochondrial membrane protein, directly bound to sesaminol...
  23. Pietropaolo A, Pierri C, Palmieri F, Klingenberg M. The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes. Biochim Biophys Acta. 2016;1857:772-81 pubmed publisher
    ..Upon binding AMP and guanine nucleotides a deeper free-energy level stabilized the intermediate-state of the AAC2 hampering the transition to the m-state...
  24. Gerenton G, Giraudet F, Djennaoui I, Pavier Y, Gilain L, Mom T, et al. Abnormal fast fluctuations of electrocochleography and otoacoustic emissions in Menière's disease. Hear Res. 2015;327:199-208 pubmed publisher
    ..The phase of the 2f1-f2 DPOAEs was monitored during body tilt, with stimuli f1 = 1 kHz and f2 = 1...
  25. Kokoszka J, Waymire K, Flierl A, Sweeney K, Angelin A, MacGregor G, et al. Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. Biochim Biophys Acta. 2016;1857:1203-1212 pubmed publisher
    ..The predominant isoform is the heart-muscle-brain ANT-isoform gene 1 (Ant1) while the other is the systemic Ant2 gene...
  26. Cho J, Seo J, Lim C, Yang L, Shiratsuchi T, Lee M, et al. Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell Death Differ. 2015;22:1437-50 pubmed publisher
    ..Mice have three ANT paralogs, Ant1 (Slc25a4), Ant2 (Slc25a5) and Ant4 (Slc25a31), which are expressed in a tissue-dependent manner...
  27. Martin G, Stagner B, Dong W, Lonsbury Martin B. Comparing Distortion Product Otoacoustic Emissions to Intracochlear Distortion Products Inferred from a Noninvasive Assay. J Assoc Res Otolaryngol. 2016;17:271-87 pubmed publisher
    ..This approach was used in alert rabbits and anesthetized gerbils to compare ear-canal 2f1-f2 and 2f2-f1 DPOAE f2/f1 ratio functions, level/phase (L/P) maps, and interference-response areas (IRAs) to their ..
  28. Oue Y, Murakami S, Isshiki K, Tsuji A, Yuasa K. Intracellular localization and binding partners of death associated protein kinase-related apoptosis-inducing protein kinase 1. Biochem Biophys Res Commun. 2018;496:1222-1228 pubmed publisher
    ..These findings suggest that DRAK1 translocates in response to stimuli and induces apoptosis through its interaction with specific binding partners, p53 and/or ANT2.
  29. Gavaldà Navarro A, Mampel T, Viñas O. Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status. Open Biol. 2016;6:150108 pubmed publisher
    ..Thus, cancer cells require both hANT2 and hANT3, depending on their proliferation status: hANT2 when proliferation rates are high, and hANT3 when proliferation slows. ..
  30. Schiebel K, Mertz A, Winkelmann M, Nagaraja R, Rappold G. Localization of the adenine nucleotide translocase gene ANT2 to chromosome Xq24-q25 with tight linkage to DXS425. Genomics. 1994;24:605-6 pubmed
  31. Bottero V, Rossi F, Samson M, Mari M, Hofman P, Peyron J. Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator. J Biol Chem. 2001;276:21317-24 pubmed
    ..NF-kappaB appeared to be released from mitochondria upon the induction of apoptosis by engagement of the Fas receptor. These data suggest that the mitochondrial IkappaB-alpha.NF-kappaB pool participates in the regulation of apoptosis. ..
  32. Eroshenko G, Nosov N, Krasnov Y, Oglodin Y, Kukleva L, Guseva N, et al. Yersinia pestis strains of ancient phylogenetic branch 0.ANT are widely spread in the high-mountain plague foci of Kyrgyzstan. PLoS ONE. 2017;12:e0187230 pubmed publisher
    ..It was found that forty two strains belong to 0.ANT2, 0.ANT3 and 0.ANT5 phylogenetic branches. From these, strains of 0.ANT2 and 0...
  33. Chen S, Chang C, Huebner K, Ku D, McFarland M, DeRiel J, et al. A human ADP/ATP translocase gene has seven pseudogenes and localizes to chromosome X. Somat Cell Mol Genet. 1990;16:143-9 pubmed
    ..Therefore, the human ADP/ATP translocase genes are members of a multigene family that includes pseudogenes and has been dispersed to at least two chromosomes. ..
  34. Martin I, Kim J, Lee B, Kang H, Xu J, Jia H, et al. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell. 2014;157:472-485 pubmed publisher
    ..These results reveal a novel mechanism of PD pathogenesis linked to elevated LRRK2 kinase activity and aberrant protein synthesis in vivo. ..
  35. Lu A, Lv B, Qiu F, Wang X, Cao X. Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma. Oncol Rep. 2017;37:2071-2078 pubmed publisher
    ..In the present study, we found that adenine nucleotide translocator 2 (ANT2) was upregulated in sorafenib?resistant HCC Huh7 cells (Huh7-R) and its overexpression promoted sorafenib ..
  36. Mahendrarajah N, Borisova M, Reichardt S, Godmann M, Sellmer A, Mahboobi S, et al. HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3. Cell Signal. 2017;39:9-17 pubmed publisher
    ..In addition to these molecular insights, our data offer a pharmacological strategy to control the ACK1-STAT signalling axis. ..
  37. Davison E, Pennington K, Hung C, Peng J, Rafiq R, Ostareck Lederer A, et al. Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function. Proteomics. 2009;9:4284-97 pubmed publisher
    ..purification/MS revealed 14 potential interactants of Parkin; CKB, DBT, HSPD1, HSPA9, LRPPRC, NDUFS2, PRDX6, SLC25A5, TPI1, UCHL1, UQCRC1, VCL, YWHAZ, YWHAE...
  38. Palmieri F. The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch. 2004;447:689-709 pubmed
    ..It is likely that further extension and functional characterization of the SLC25 gene family will elucidate other diseases caused by MC deficiency. ..
  39. Schlattner U, Dolder M, Wallimann T, Tokarska Schlattner M. Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium. J Biol Chem. 2001;276:48027-30 pubmed
    ..No interaction of MtCK with reconstituted adenine nucleotide translocator was detectable in our experimental setup. The relevance of these findings for structure and function of mitochondrial contact sites is discussed. ..
  40. Smith S, Ichiba K, Velenovsky D, Cone B. Efferent modulation of pre-neural and neural distortion products. Hear Res. 2017;356:25-34 pubmed publisher
    ..DPOAE fine structure peak inhibition and inhibition of DPFFR components representing neural phase locking to f2 and 2f1-f2, but not f1...
  41. Kuramori C, Azuma M, Kume K, Kaneko Y, Inoue A, Yamaguchi Y, et al. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. Biochem Biophys Res Commun. 2009;379:519-25 pubmed publisher
    ..This work will serve as an important foundation for further understanding of anticancer activity of capsaicin. ..
  42. Kashiwaya K, Hosokawa M, Eguchi H, Ohigashi H, Ishikawa O, Shinomura Y, et al. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. Cancer Sci. 2009;100:457-64 pubmed publisher
    ..showed that C2orf18 was localized in the mitochondria and it could interact with adenine nucleotide translocase 2 (ANT2), which is involved in maintenance of the mitochondrial membrane potential and energy homeostasis, and was ..
  43. Baik S, Lee J, Lee Y, Jang J, Kim C. ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells. Exp Mol Med. 2016;48:e222 pubmed publisher
    ..We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by short hairpin RNA (shRNA) inhibits hepatocellular carcinoma (HCC) development by rescuing miR-636 expression...
  44. Ito S, Tan L, Andoh D, Narita T, Seki M, Hirano Y, et al. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Mol Cell. 2010;39:632-40 pubmed publisher
    ..Instead, it included FAM96B (now designated MIP18), Ciao1, and ANT2. MMS19, MIP18, and XPD localized to the mitotic spindle during mitosis...
  45. Piwko W, Olma M, Held M, Bianco J, Pedrioli P, Hofmann K, et al. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. EMBO J. 2010;29:4210-22 pubmed publisher
    ..Together, our results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. ..
  46. Cui J, Yu M, Niu J, Yue Z, Xu Z. Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system. Biosci Rep. 2011;31:429-37 pubmed publisher
    ..Thus, our study provides the rational for clinical trials using creatine to treat PD and supports the notion of exploiting LRRK2 as a drug target for PD. ..
  47. Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh Hain J, et al. Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med. 2012;4:952-63 pubmed publisher
    ..Instead, CKI? was found to interact with several mitochondrial proteins including adenine nucleotide translocase 2 (ANT2)...
  48. van Wietmarschen N, Moradian A, Morin G, Lansdorp P, Uringa E. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. J Biol Chem. 2012;287:43351-8 pubmed publisher
    ..Furthermore, we show that ADP/ATP translocase 2 (ANT2) interacts with Fe-S apoproteins and MMS19 in the CIA complex but not with the individual proteins...
  49. Hubackova S, Kucerová A, Michlits G, Kyjacova L, Reinis M, Korolov O, et al. IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2. Oncogene. 2016;35:1236-49 pubmed publisher
    ..Furthermore, the expression of adenine nucleotide translocase 2 (ANT2) was suppressed by IFNγ contributing to elevation of ROS and DNA damage...
  50. Jang J, Jeon Y, Lee C, Kim C. ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression. Int J Oncol. 2013;42:574-82 pubmed publisher
    ..Here, we examined the influence of adenine nucleotide translocase 2 (ANT2) suppression by short-hairpin RNA (shRNA) on SOCS1 expression and its downstream effect in HCC...
  51. Chen C, Su Y, Baybayan P, Siruno A, Nagaraja R, Mazzarella R, et al. Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. Nucleic Acids Res. 1996;24:4034-41 pubmed
    ..The sequence of 135 038 nt contains the entire ANT2 cDNA as well as four other candidates suggested by computer-assisted analyses...
  52. Giraud S, Bonod Bidaud C, Wesolowski Louvel M, Stepien G. Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria. J Mol Biol. 1998;281:409-18 pubmed
    ..The ANT gene expression was examined in several human cells. The gene encoding the ANT2 isoform was found specifically induced in Simian virus 40 (SV40)-transformed, tumoral and mtDNA lacking rho degrees ..
  53. Jacotot E, Ravagnan L, Loeffler M, Ferri K, Vieira H, Zamzami N, et al. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med. 2000;191:33-46 pubmed
    ..Hence, Vpr induces apoptosis via a direct effect on the mitochondrial PTPC. ..
  54. Jang J, Kim Y, Nam S, Keam B, Kim T, Jeon Y, et al. Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2016;15:1387-96 pubmed publisher
    ..Adenine nucleotide translocase-2 (ANT2) is an oncogenic mitochondrial membrane-associated protein...
  55. Ho L, Titus A, Banerjee K, George S, Lin W, Deota S, et al. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013;5:835-49 pubmed
    ..We find that Sirt4 affects mitochondrial uncoupling via the adenine nucleotide translocator 2 (ANT2)...
  56. Vandewalle J, Bauters M, Van Esch H, Belet S, Verbeeck J, Fieremans N, et al. The mitochondrial solute carrier SLC25A5 at Xq24 is a novel candidate gene for non-syndromic intellectual disability. Hum Genet. 2013;132:1177-85 pubmed publisher
    ..of overlap, confirmed by junction sequencing, harbors two members of the mitochondrial solute carrier family 25, SLC25A5 and SLC25A43...
  57. Oishi M, Iizumi Y, Taniguchi T, Goi W, Miki T, Sakai T. Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2. PLoS ONE. 2013;8:e55922 pubmed publisher
    ..Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced apoptosis by upregulation of DR5...
  58. Jang J, Lee Y, Jeon Y, Lee K, Jang J, Kim C. ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma. Exp Mol Med. 2013;45:e3 pubmed publisher
    ..We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin RNA (shRNA) approach has an antitumor effect in several cancer cells...
  59. Nishimura M, Naito S, Yokoi T. Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies. Drug Metab Pharmacokinet. 2004;19:135-49 pubmed
    ..NR1A1, 1A2, 1B1, 1B2, 1B3, 1C1, 1C2, 1C3, 1D1, 1D2, 1F1, 1F2, 1F3, 1H2, 1H3, 1I1, 1I2, 2B1, 2B2, 2B3, 2C1, 2C2, 2F1, 2F2, 3A2, 3B1, 3C1, 3C2, 3C4, 4A1, 4A2, 4A3, and 6A1) was successfully detected in all of the tissues by this ..
  60. Zhu B, Zhai J, Zhu H, Kyprianou N. Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling. Prostate. 2010;70:17-26 pubmed publisher
    ..These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF-beta via Smad-dependent pathway (apoptosis) and MAPK intracellular signaling (survival). ..
  61. Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson S, Florens L, et al. Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle. Proc Natl Acad Sci U S A. 2007;104:11778-83 pubmed publisher
  62. Luciakova K, Kollarovic G, Barath P, Nelson B. Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. Biochem J. 2008;412:123-30 pubmed publisher
    NF1 (nuclear factor 1) binds to two upstream elements of the human ANT2 (adenine nucleotide translocator-2) promoter and actively represses expression of the gene in growth-arrested diploid skin fibroblasts [Luciakova, Barath, Poliakova, ..
  63. Battini R, Ferrari S, Kaczmarek L, Calabretta B, Chen S, Baserga R. Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated. J Biol Chem. 1987;262:4355-9 pubmed
    ..RNA levels of the ADP/ATP carrier decrease instead when growing HL-60 cells are induced to differentiate by either phorbol esters or retinoic acid. ..
  64. Dallabona C, Baruffini E, Goffrini P, Lodi T. Dominance of yeast aac2R96H and aac2R252G mutations, equivalent to pathological mutations in ant1, is due to gain of function. Biochem Biophys Res Commun. 2017;493:909-913 pubmed publisher
    ..or to a gain of function, the two mutations have been introduced in the equivalent positions of the AAC2 gene, the yeast orthologue of human ANT1, and their dominant effect has been studied in heteroallelic strains, ..
  65. Cho J, Zhang Y, Park S, Joseph A, Han C, Park H, et al. Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. Nat Commun. 2017;8:14477 pubmed publisher
    ..Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed in the liver...
  66. Lenhausen A, Wilkinson A, Lewis E, Dailey K, Scott A, Khan S, et al. Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis. Biochemistry. 2016;55:3285-302 pubmed publisher
    ..Overall this study identifies an AIF/PGAM5/XIAP axis that can regulate PGAM5 activities related to the antioxidant response and mitophagy. ..
  67. Kretova M, Sabova L, Hodny Z, Bartek J, Kollarovic G, Nelson B, et al. TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence. Cell Signal. 2014;26:2903-11 pubmed publisher
    ..Here, we report that adenine nucleotide translocase-2 (ANT2) is consistently down-regulated in all three major forms of cellular senescence: replicative, oncogene-induced and ..
  68. Deniaud A, Brenner C, Kroemer G. Mitochondrial membrane permeabilization by HIV-1 Vpr. Mitochondrion. 2004;4:223-33 pubmed
    ..Accordingly, Vpr modulates MMP through direct structural and functional interactions with PTPC proteins. ..
  69. Wu R, Tan Q, Niu K, Zhu Y, Wei D, Zhao Y, et al. MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage. Biochem Cell Biol. 2017;: pubmed publisher
    ..Immunoprecipitation-mass spectrometry analysis identified that MMS19 interacts with ANT2, a mitochondrial ATP metabolism-associated protein...
  70. Maldonado E, Dehart D, Patnaik J, Klatt S, Gooz M, Lemasters J. ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem. 2016;291:19642-50 pubmed publisher
    ..However in cancer cells, BA, CAT, and knockdown of the major ANT isoforms, ANT2 and ANT3, did not collapse ?? after respiratory inhibition...
  71. Liu Y, Pu Q, Wu M, Yu C. Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes. Xenobiotica. 2016;46:940-7 pubmed publisher
    ..Among those, protein levels of hepatic drug transporters (MRP2, ABCD3, OAT2, SLC25A12, SCL38A3, SLC2A2 and SLC25A5) and metabolizing enzymes (CYP2B3, CYP2C7, CYP2C11, CYP2C13, CYP4A2 and UGT2B) were markedly reduced, but the ..
  72. De Marcos Lousa C, Trezeguet V, Dianoux A, Brandolin G, Lauquin G. The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae. Biochemistry. 2002;41:14412-20 pubmed
    ..These results point to the importance of the N-terminal region of HAnc1p for its biogenesis and transport activity in yeast mitochondria. ..
  73. Ku D, Kagan J, Chen S, Chang C, Baserga R, Wurzel J. The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. J Biol Chem. 1990;265:16060-3 pubmed
    ..Differences among the sequence motifs of the 5'-flanking region of the three human translocase genes could account for differences in their cell type-specific and proliferation-associated expression. ..