SLC25A18

Summary

Gene Symbol: SLC25A18
Description: solute carrier family 25 (glutamate carrier), member 18
Alias: GC2, GC-2, glutamate/H(+) symporter 2, mitochondrial glutamate carrier 2, solute carrier family 25 (mitochondrial carrier), member 18, solute carrier family 25 member 18
Species: human

Top Publications

  1. pmc Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation
    Padmaja Tummala
    Eye Research Institute, Oakland University, Rochester, MI 48309 4401, USA
    Mol Vis 16:252-71. 2010
  2. pmc Gitelman syndrome
    Nine V A M Knoers
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Orphanet J Rare Dis 3:22. 2008
  3. doi Cationic and neutral amino acid transporter transcript abundances are differentially expressed in the equine intestinal tract
    A D Woodward
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Anim Sci 88:1028-33. 2010
  4. ncbi The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, University Hospital, 8091, Zurich, Switzerland
    Handb Exp Pharmacol 201:205-59. 2011
  5. ncbi Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women
    A L Lauridsen
    Department of Clinical Biochemistry, NBG, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 77:15-22. 2005
  6. ncbi cDNAs from Onchocerca sp. encoding members of the MRS3/MRS4 class of mitochondrial solute carriers
    J Catmull
    Department of Biochemistry and Molecular Biology, James Cook University of North Queensland, Townsville, Australia
    Biochim Biophys Acta 1282:179-81. 1996
  7. doi Interaction of anion exchanger 1 and glycophorin A in human erythroleukaemic K562 cells
    Allison J Pang
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Medical Sciences Building, Toronto, Canada, M5S 1A8
    Biochem J 421:345-56. 2009
  8. doi Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population
    Rong Lin
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, and Ruijin Hospital, Shanghai, China
    Pharmacogenet Genomics 19:310-8. 2009
  9. ncbi Phenotypes of SLC26A4 gene mutations: Pendred syndrome and hypoacusis with enlarged vestibular aqueduct
    Katarzyna Maciaszczyk
    Department of Otolaryngology, Medical University of Lodz, University Hospital No 1, Lodz, Poland
    Neuro Endocrinol Lett 29:29-36. 2008
  10. pmc Xenobiotic, bile acid, and cholesterol transporters: function and regulation
    Curtis D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Pharmacol Rev 62:1-96. 2010

Research Grants

  1. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2010
  2. Defining Antigenic Targets of Autoimmune Sensorineural Hearing Loss
    Thomas E Carey; Fiscal Year: 2010
  3. PHARMACOGENETICS OF MEMBRANE TRANSPORTERS
    Kathleen Giacomini; Fiscal Year: 2007
  4. PHARMACOGENETICS OF MEMBRANE TRANSPORTERS
    Kathleen Giacomini; Fiscal Year: 2007
  5. Structural Biology of the Apical Bile Acid Transporter.
    Peter Swaan; Fiscal Year: 2009
  6. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2010
  7. Studies of Erythrocyte Membrane Structure
    Philip Stewart Low; Fiscal Year: 2010
  8. Studies of Erythrocyte Membrane Structure
    Philip Low; Fiscal Year: 2009
  9. A Mouse Model of Acrodermatitis Enteropathica
    Glen Andrews; Fiscal Year: 2009
  10. A Mouse Model of Acrodermatitis Enteropathica
    Glen K Andrews; Fiscal Year: 2010

Detail Information

Publications138 found, 100 shown here

  1. pmc Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation
    Padmaja Tummala
    Eye Research Institute, Oakland University, Rochester, MI 48309 4401, USA
    Mol Vis 16:252-71. 2010
    ..Some of these elusive gene activation events can be detected by mapping changes in RNA polymerase-II (Pol-II) association around transcription start sites...
  2. pmc Gitelman syndrome
    Nine V A M Knoers
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Orphanet J Rare Dis 3:22. 2008
    ..Cardiac work-up should be offered to screen for risk factors of cardiac arrhythmias. All GS patients are encouraged to maintain a high-sodium and high potassium diet. In general, the long-term prognosis of GS is excellent...
  3. doi Cationic and neutral amino acid transporter transcript abundances are differentially expressed in the equine intestinal tract
    A D Woodward
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Anim Sci 88:1028-33. 2010
    ..Results indicate that the large intestine might contribute to both cationic and neutral AA uptake and absorption predominantly via transporters LAT-3 and b(0,+)AT...
  4. ncbi The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, University Hospital, 8091, Zurich, Switzerland
    Handb Exp Pharmacol 201:205-59. 2011
    ..It is, however, subject to inhibition by endogenous metabolites or by drugs. A sustained inhibition will lead to acquired cholestasis, which can end in liver injury...
  5. ncbi Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women
    A L Lauridsen
    Department of Clinical Biochemistry, NBG, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 77:15-22. 2005
    ..between women with different Gc phenotype, being highest in Gc1-1, intermediate in Gc1-2, and lowest in Gc2-2...
  6. ncbi cDNAs from Onchocerca sp. encoding members of the MRS3/MRS4 class of mitochondrial solute carriers
    J Catmull
    Department of Biochemistry and Molecular Biology, James Cook University of North Queensland, Townsville, Australia
    Biochim Biophys Acta 1282:179-81. 1996
    ..elegans, but levels of identity between these and the Onchocerca proteins were considerably lower. Consideration of cysteine content and overall charge implies that the natural substrates of the nematode proteins are small ions...
  7. doi Interaction of anion exchanger 1 and glycophorin A in human erythroleukaemic K562 cells
    Allison J Pang
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Medical Sciences Building, Toronto, Canada, M5S 1A8
    Biochem J 421:345-56. 2009
    ..The results indicate that AE1 and GPA form a complex in the ER of human K562 cells, but that both proteins can also traffic to the cell surface independently of each other...
  8. doi Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population
    Rong Lin
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, and Ruijin Hospital, Shanghai, China
    Pharmacogenet Genomics 19:310-8. 2009
    ....
  9. ncbi Phenotypes of SLC26A4 gene mutations: Pendred syndrome and hypoacusis with enlarged vestibular aqueduct
    Katarzyna Maciaszczyk
    Department of Otolaryngology, Medical University of Lodz, University Hospital No 1, Lodz, Poland
    Neuro Endocrinol Lett 29:29-36. 2008
    ..e., IVS8+1G-A, in a total of 55% of the patients with recognised mutation of SLC26A4 gene; the remaining 45% of changes of this gene are unique mutations...
  10. pmc Xenobiotic, bile acid, and cholesterol transporters: function and regulation
    Curtis D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Pharmacol Rev 62:1-96. 2010
    ..Transporters are important transmembrane proteins that mediate the cellular entry and exit of a wide range of substrates throughout the body and thereby play important roles in human physiology, pharmacology, pathology, and toxicology...
  11. ncbi SLC45A2 variations in Indian oculocutaneous albinism patients
    Mainak Sengupta
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Kolkata, West Bengal, India
    Mol Vis 13:1406-11. 2007
    ..Interestingly, in almost 31% of the cases, the second mutation has never been found. The purpose of this study was to investigate the molecular basis of OCA among Indians using SLC45A2 as the candidate gene...
  12. doi Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids
    Samuel E Gilchrist
    University of British Columbia, Vancouver, Canada
    Fundam Clin Pharmacol 24:205-14. 2010
    ....
  13. doi Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 395:261-75. 2010
    ..This study focused on these tumors and analyzed the association of gene expression profiles to clinical outcome...
  14. pmc Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail
    Ulrika Gunnarsson
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75124 Uppsala, Sweden
    Genetics 175:867-77. 2007
    ..It is an enigma why recessive null mutations at this locus cause an almost complete absence of both eumelanin and pheomelanin whereas some missense mutations are dominant and cause a specific inhibition of pheomelanin production...
  15. doi Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations
    Rong Lin
    Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Hum Mutat 30:609-15. 2009
    ..Finally, we observed that significant differences of TBIL levels existed among the three populations; however, this could not be completely explained by the differences at the (TA)n repeat polymorphism and SNP rs4148323:G>A...
  16. ncbi Cytidine-5'-diphosphocholine (citicoline) improves retinal and cortical responses in patients with glaucoma
    V Parisi
    Cattedra di Clinica Oculistica, Universita di Roma Tor Vergata, Rome, Italy
    Ophthalmology 106:1126-34. 1999
    ..To evaluate the effects of cytidine-5'-diphosphocholine (citicoline) on retinal function and on cortical responses in patients with glaucoma...
  17. pmc Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract
    Takeshi Uemura
    The Arizona Cancer Center, University of Arizona, Tucson, USA
    Am J Physiol Gastrointest Liver Physiol 299:G517-22. 2010
    ....
  18. doi Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig populations
    A I Sironen
    Agrifood Research Finland, MTT, Biotechnology and Food Research, Genomics, FI 36100 Jokioinen, Finland
    J Anim Sci 88:821-7. 2010
    ..These results support the suitability of the candidate gene approach for identification of markers to improve the reproductive performance of sows and to provide potential markers for marker-assisted selection...
  19. ncbi Rod outer segment membrane guanylate cyclase type 1-linked stimulatory and inhibitory calcium signaling systems in the pineal gland: biochemical, molecular, and immunohistochemical evidence
    V Venkataraman
    The Unit of Regulatory and Molecular Biology, Departments of Cell Biology and Ophthalmology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
    Biochemistry 39:6042-52. 2000
    ..The presence of ROS-GC2 was not detected in the pineal gland...
  20. pmc Subtype-specific regulation of equilibrative nucleoside transporters by protein kinase CK2
    Meaghan Stolk
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochem J 386:281-9. 2005
    ....
  21. ncbi Variations in equid SLC11A1 (NRAMP1) genes and associations with Rhodococcus equi pneumonia in horses
    Natalie D Halbert
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station 77843 4475, USA
    J Vet Intern Med 20:974-9. 2006
    ..equi foal pneumonia and other intracellular bacterial diseases affecting equids...
  22. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
    ..Haplotypes of the DBP SNPs correspond to protein variations referred to as Gc1s (haplotype 1), Gc2 (haplotype 2), and Gc1f (haplotype3)...
  23. pmc Analysis and update of the human solute carrier (SLC) gene superfamily
    Lei He
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA 02114, USA
    Hum Genomics 3:195-206. 2009
    ..Understanding and characterising the functions of these transporters is relevant to medicine, genetics, developmental biology, pharmacology and cancer chemotherapy...
  24. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
    ..Most studies addressed these genes individually, often with different populations providing conflicting results...
  25. ncbi Functional insights into the creatine transporter
    David L Christie
    Molecular, Cell and Developmental Biology Section, School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Subcell Biochem 46:99-118. 2007
    ..Development of suitable mouse models may allow improved understanding of the importance of the CRT for normal brain function and how the transporter is regulated in vivo...
  26. ncbi The C-terminus of prestin influences nonlinear capacitance and plasma membrane targeting
    Jing Zheng
    Auditory Physiology Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208 USA
    J Cell Sci 118:2987-96. 2005
    ..Together, these data suggest that certain specific sequences and individual amino acids in the C-terminus are necessary for correct cellular distribution and function...
  27. pmc Cloning and functional expression of the first eukaryotic Na+-tryptophan symporter, AgNAT6
    Ella A Meleshkevitch
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Exp Biol 212:1559-67. 2009
    ....
  28. pmc A perchlorate sensitive iodide transporter in frogs
    Deborah L Carr
    Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Gen Comp Endocrinol 156:9-14. 2008
    ..We conclude that the amphibian sequence encodes a protein that is indeed a functional Na(+)/iodide symporter in X. laevis, as well as R. catesbeiana...
  29. ncbi Solute carrier family 11 member A1 gene polymorphisms in reactive arthritis
    Yi Jing Chen
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Clin Immunol 27:46-52. 2007
    ..The SLC 11A1 274T 823C 1703G 1729+55 del 4 TGTG+ haplotype is associated with the development of reactive arthritis in Taiwan. In contrast, the SLC 11A1 274C 823T 1703G 1729+55 del 4 TGTG+ haplotype may be a protective factor...
  30. pmc Human solute carrier SLC6A14 is the beta-alanine carrier
    Catriona M H Anderson
    Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    J Physiol 586:4061-7. 2008
    ....
  31. doi Efficacy of in-feed probiotics against Aeromonas bestiarum and Ichthyophthirius multifiliis skin infections in rainbow trout (Oncorhynchus mykiss, Walbaum)
    N Pieters
    School of Life Sciences, Heriot Watt University, Edinburgh, UK
    J Appl Microbiol 105:723-32. 2008
    ..The aim of this study was to assess the efficacy of in-feed probiotics as a preventive measure against skin infections caused by Aeromonas bestiarum and Ichthyophthirius multifiliis (Ich) in rainbow trout...
  32. ncbi Female premenopausal fracture risk is associated with gc phenotype
    Anna Lis Lauridsen
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, Aarhus C, Denmark
    J Bone Miner Res 19:875-81. 2004
    ..This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years)...
  33. doi Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine
    Volodymyr Shnitsar
    Abteilung Vegetative Physiologie und Pathophysiologie, Georg August Universitat, Gottingen, Germany
    Cancer Res 69:1494-501. 2009
    ..Thus, our data support the hypothesis that the sensitivity of tumor cells to chemotherapeutic treatment depends on the expression of transporter proteins mediating specific drug accumulation into target cells...
  34. pmc Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative
    Zhou Zhang
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 Northwest 10th Avenue, Miami, Florida 33136, USA
    Biochemistry 46:3872-80. 2007
    ..The implications of these results for the mechanisms of transmembrane transport of alanine are discussed. The new caged alanine derivative will provide a useful tool for future, more detailed studies of neutral amino acid transport...
  35. ncbi Expression level and activity profile of membrane bound guanylate cyclase type 2 in rod outer segments
    Andreas Helten
    Biochemistry Group, Institute of Biology and Environmental Sciences, Faculty V, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
    J Neurochem 103:1439-46. 2007
    ..two types of a membrane bound guanylate cyclase (GC), rod outer segment guanylate cyclase type 1 (ROS-GC1) and ROS-GC2. Both enzymes are regulated by small Ca(2+)-binding proteins named GC-activating proteins that operate as Ca2+ ..
  36. pmc Rescue from oculocutaneous albinism type 4 using medaka slc45a2 cDNA driven by its own promoter
    Shoji Fukamachi
    Department of Integrated Biosciences, University of Tokyo, Chiba, Japan
    Genetics 178:761-9. 2008
    ..Further studies of the 0.9-kb promoter identified in this study should provide insights into the cis/trans-regulatory mechanisms underlying the ocular and cutaneous expression of slc45a2...
  37. doi Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters
    Xin Ming
    Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, 3309 Kerr Hall, CB 7360, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    Drug Metab Dispos 37:424-30. 2009
    ..These transporters may play important roles in the disposition of aromatic diamidines in humans, as well as resultant drug-drug interactions and toxicity involving diamidine drugs...
  38. doi Comprehensive two-dimensional gas chromatography combustion isotope ratio mass spectrometry
    Herbert J Tobias
    Division of Nutritional Sciences, Cornell University, Savage Hall, Ithaca, New York 14853, USA
    Anal Chem 80:8613-21. 2008
    ..interface to preserve <300 ms full width at half-maximum (fwhm) fast GC peaks generated on the second GC column (GC2)...
  39. ncbi Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival
    Sotiria Sotiriou
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 8:514-7. 2002
    ..Deficiency of the transporter is lethal in newborn mice, thereby revealing a previously unrecognized requirement for ascorbic acid in the perinatal period...
  40. ncbi Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types
    A Braun
    Institut für Anthropologie und Humangenetik Universität, Munchen, Federal Republic of Germany
    Hum Genet 89:401-6. 1992
    ..The GC2 and GC1F phenotypes have an aspartic acid residue at amino acid position 416, whereas the GC1S phenotype has a ..
  41. doi Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders
    Hung Pin Tu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Ann Rheum Dis 69:887-90. 2010
    ..To study the associations of gout, tophi and uric acid levels with the gout-related SLC2A9 (solute carrier family 2, member 9) single nucleotide polymorphisms (SNPs) between two different racial groups...
  42. ncbi Function and mechanism of action of Dictyostelium Nramp1 (Slc11a1) in bacterial infection
    Barbara Peracino
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    Traffic 7:22-38. 2006
    ..pneumophila infection. Evidence is provided that Nramp1 transports metal cations out of the phagolysosome in an ATP-dependent process and that L. pneumophila and M. avium use different mechanisms to neutralize Nramp1 activity...
  43. doi Complex profiles of hydrophobic paralytic shellfish poisoning compounds in Gymnodinium catenatum identified by liquid chromatography with fluorescence detection and mass spectrometry
    Paulo Vale
    Instituto Nacional dos Recursos Biologicos IPIMAR, Avenida de Brasília s n, 1449 006 Lisbon, Portugal
    J Chromatogr A 1195:85-93. 2008
    ..fractions by LC-MS demonstrated the second sub-group was constituted by analogues of the 11-hydroxysulfated GC1/GC2, while the third sub-group was constituted by analogues of GC3, which lack the 11-hydroxysulfate...
  44. ncbi Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata
    Patricia W Stewart
    Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, 1800 Denison Ave, Kansas State University, Manhattan, Kansas 66506, USA
    Comp Med 53:70-4. 2003
    ..obvelata. These data justify further comprehensive analyses of the immune components that are involved in pinworm resistance...
  45. doi Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression
    Kerstin Klein
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 296:G936-47. 2009
    ..Supporting the physiological relevance and species conservation of this effect, ileal Cnt1 mRNA expression was decreased upon bile acid feeding and increased upon bile duct ligation in mice...
  46. doi Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells
    Masahiro Tsuda
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 329:185-91. 2009
    ..These results suggest that apical hMATE1 is involved in drug interactions between cimetidine and cationic compounds in the proximal tubular epithelial cells...
  47. pmc Functionally important amino acids in the Arabidopsis thylakoid phosphate transporter: homology modeling and site-directed mutagenesis
    Lorena Ruiz-Pavón
    Division of Molecular Genetics, Department of Physics, Chemistry, and Biology, Linkoping University, Linkoping, Sweden
    Biochemistry 49:6430-9. 2010
    ..Functional characterization of ANTR1 should provide useful insights into the function of other plant and mammalian SLC17 homologous transporters...
  48. doi Clinical implications of pharmacogenetic variation on the effects of statins
    Simran D S Maggo
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Drug Saf 34:1-19. 2011
    ....
  49. doi Complex multifactorial nature of significant hyperbilirubinemia in neonates
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 124:e868-77. 2009
    ....
  50. doi The solute carrier 44A1 is a mitochondrial protein and mediates choline transport
    Vera Michel
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
    FASEB J 23:2749-58. 2009
    ..SLC44A1 mRNA and protein expression were down-regulated during choline deficiency. These data clearly establish SLC44A1 as an important mediator of choline transport across both the plasma membrane and the mitochondrial membrane...
  51. pmc The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors
    Wolfgang Baehr
    Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 282:8837-47. 2007
    Retinal guanylate cyclases 1 and 2 (GC1 and GC2) are responsible for synthesis of cyclic GMP in rods and cones, but their individual contributions to phototransduction are unknown...
  52. ncbi Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance
    Maria Pia Sperandeo
    Dept of Pediatrics, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
    Am J Physiol Cell Physiol 293:C191-8. 2007
    ..This mouse model offers new insights into the pathophysiology of LPI and into mechanisms linking CAA metabolic pathways and growth control...
  53. pmc Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice
    Diana L Shuster
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 41:332-42. 2013
    ..This study demonstrates important gestational age-dependent expression of metabolic enzyme and transporter genes, which may have mechanistic relevance to drug disposition in human pregnancy...
  54. ncbi Regional distribution of solute carrier mRNA expression along the human intestinal tract
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Drug Metab Dispos 35:590-4. 2007
    ..Furthermore, changes in transporter expression that occur in pathological states, such as inflammatory bowel disease, can now be defined more precisely by comparison with the expression levels measured in healthy individuals...
  55. pmc Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibody
    Lauren M Hook
    Infectious Disease Division, Department of Medicine, 502 Johnson Pavilion, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6073, USA
    J Virol 80:4038-46. 2006
    ..Differences in complement interacting domains exist between gC of HSV-1 (gC1) and HSV-2 (gC2), since the amino terminus of gC1 blocks complement C5 from binding to C3b, while gC2 fails to interfere with this ..
  56. ncbi Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians
    Emmanuelle Durand
    CNRS UMR8090, Institut Pasteur de Lille, 1 rue du Pr Calmette, BP 447 59021 Lille, France
    Diabetes 53:2483-6. 2004
    ..003 < P < 0.06). In conclusion, these data confirm an association of the SLC6A14 gene locus with obesity...
  57. pmc Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways
    Wei Wu
    Departments of Pediatrics H C L, K T B, S K N, Medicine, Division of Nephrology and Hypertension W W, S A E, S K N, Cellular and Molecular Medicine S K N, and Bioengineering N J, B O P, S K N, University of California, San Diego, La Jolla, California
    Drug Metab Dispos 41:1825-34. 2013
    ..The data seemingly consistent with the Remote Sensing and Signaling Hypothesis (Ahn and Nigam, 2009; Wu et al., 2011), also suggests that Oat3 is essential for the handling of dietary flavonoids and antioxidants. ..
  58. doi Solute carrier family 2, member 9 and uric acid homeostasis
    Chris Cheeseman
    Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Curr Opin Nephrol Hypertens 18:428-32. 2009
    ..The goal of this article is to review the possible physiological roles of the recently identified urate transporter, solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9), in the renal handling of urate...
  59. doi Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response
    G Einecke
    Department of Nephrology, Hannover Medical School, Hanover, Germany
    Am J Transplant 10:2241-51. 2010
    ..001). Thus the loss of epithelial transcripts in rejection is not a unique consequence of T cell-mediated rejection but an active injury-repair response of epithelium, triggered by rejection but also by other injury mechanisms...
  60. pmc SLC22A5/OCTN2 expression in breast cancer is induced by estrogen via a novel intronic estrogen-response element (ERE)
    Chunyu Wang
    Department of Clinical Cancer Prevention, M D Anderson Cancer Center, Houston, TX 77030, USA
    Breast Cancer Res Treat 134:101-15. 2012
    ..Since SLC22A5 is a critical regulator of carnitine homeostasis, lipid metabolism, and cell proliferation, SLC22A5 may serve as a potential therapeutic target for breast cancer in the future...
  61. doi Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates
    Jana Mandíková
    Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic
    Toxicology 311:135-46. 2013
    ..This transporter may also play an important role in the mechanism of their potential cytotoxic effects. These facts are in good accordance with previous findings in the clinically used ANPs. ..
  62. pmc A novel eukaryotic Na+ methionine selective symporter is essential for mosquito development
    Ella A Meleshkevitch
    Department of Physiology and Biophysics, Rosalind Franklin University, Chicago Medical School, North Chicago, IL 60064, USA
    Insect Biochem Mol Biol 43:755-67. 2013
    ..We demonstrated specific patterns of alimentary and neuronal transcription of AeNAT5 in mosquito larvae that is collateral with the indispensable function of this transporter in mosquito development...
  63. doi Expanding role of pharmacogenomics in the management of cardiovascular disorders
    Vincent Lai Ming Yip
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Am J Cardiovasc Drugs 13:151-62. 2013
    ....
  64. doi In vitro expression of the SLC11A1 gene in goat monocyte-derived macrophages challenged with Mycobacterium avium subsp paratuberculosis
    S Taka
    Department of Anatomy and Physiology of Farm Animals, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, 75 Iera Odos St, 11855 Athens, Greece
    Infect Genet Evol 17:8-15. 2013
    ....
  65. doi The urea transporter family (SLC14): physiological, pathological and structural aspects
    Chairat Shayakul
    Renal Unit, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Mol Aspects Med 34:313-22. 2013
    ..This review provides an update of these advances and their implications for our current understanding of the SLC14 UTs...
  66. ncbi Computational models for predicting interactions with membrane transporters
    Y Xu
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, China
    Curr Med Chem 20:2118-36. 2013
    ..In the third part, the challenges of developing computational methods to get reliable prediction, as well as the potential future directions in transporter related modeling are discussed...
  67. doi Microarray-assisted fine-mapping of quantitative trait loci for cold tolerance in rice
    Fengxia Liu
    State Key Laboratory of Plant Physiology and Biochemistry, National Center for Evaluation of Agricultural Wild Plants Rice, Department of Plant Genetics and Breeding, China Agricultural University, Beijing 100193, China
    Mol Plant 6:757-67. 2013
    ..All the early seedlings of IL112 survived normally for 9 d at 4-5°C, while Guichao2 (GC2), an indica cultivar, died after 4 d under the same conditions...
  68. pmc A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport
    Isabel Jaenecke
    Department of Pharmacology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
    J Biol Chem 287:30853-60. 2012
    ..Expression analysis showed strong expression of SLC7A14 mRNA in these cells. Taken together, these data strongly suggest that SLC7A14 is a lysosomal transporter for cationic amino acids...
  69. doi Expression of the Slc12a1 gene in pancreatic β-cells: molecular characterization and in silico analysis
    Saeed Alshahrani
    Department of Pharmacology and Toxicology, Wright State University, School of Medicine, Dayton, OH 45435, USA
    Cell Physiol Biochem 30:95-112. 2012
    ..Therefore, our results provide for the first time evidence of NKCC2A expression in pancreatic β-cells where it may play a role in insulin secretion...
  70. pmc Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder
    Yanli Zhang-James
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Dev Neurosci 34:218-27. 2012
    ..Our results suggest that abnormalities in SLC9A9-mediated signaling pathways could contribute to the ADHD phenotype of two rat models (WKY/NCrl and SHR/NCrl), and that the perturbation of the SLC9A9 network is age-dependent...
  71. doi The expression of ferritin, lactoferrin, transferrin receptor and solute carrier family 11A1 in the host response to BCG-vaccination and Mycobacterium tuberculosis challenge
    R E Thom
    Microbiological Services, HPA Porton Down, Salisbury SP4 0JG, UK
    Vaccine 30:3159-68. 2012
    ..tuberculosis infection and that BCG-vaccination enhances the ability of the host to mount an iron-restriction response which may in turn help to combat invasion by mycobacteria...
  72. ncbi Identification and characterization of a novel monoamine transporter in the human brain
    Karen Engel
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:50042-9. 2004
    ..These studies demonstrate that PMAT may be a novel low affinity transporter for biogenic amines, which, under certain conditions, might supplement the role of the high affinity transporters in the brain...
  73. ncbi Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains
    Hannes Lohi
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland
    Am J Physiol Cell Physiol 284:C769-79. 2003
    ..Our results support the general concept of microdomain organization for ion transport and suggest a mechanism for cystic fibrosis transmembrane regulator (CFTR)-mediated SLC26A6 upregulation in pancreatic duct cells...
  74. doi 25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease
    Masahiko Suzuki
    Department of Neurology, Jikei University School of Medicine, Tokyo, Japan
    Mov Disord 27:264-71. 2012
    ..rs11568820), ApaI (rs7976091), and TaqI (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross-sectional study. Mean ± standard deviation levels of 25-hydroxyvitamin D were 21.1 ± 9...
  75. pmc Molecular cloning of a peroxisomal Ca2+-dependent member of the mitochondrial carrier superfamily
    F E Weber
    Klinik für Gesichts und Kieferchirurgie, Universitatsspital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 94:8509-14. 1997
    ..Immunoelectron microscopy localized the transporter in the peroxisome, although a minor fraction was found in the mitochondria. The Ca2+ binding N-terminal half of the transporter faces the cytosol...
  76. pmc Enhanced survival in vitro of human corneal endothelial cells using mouse embryonic stem cell conditioned medium
    Xiaoyan Lu
    State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, PR China
    Mol Vis 16:611-22. 2010
    ..To determine whether mouse embryonic stem cell conditioned medium (ESC-CM) increases the proliferative capacity of human corneal endothelial cells (HCECs) in vitro...
  77. doi Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine
    Takuji Suzuki
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Biochem J 435:43-53. 2011
    ....
  78. pmc The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes
    Zhou Zhang
    College of Life and Environment Sciences, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234, China
    Biochem J 434:287-96. 2011
    ..However, the C-terminus appears not to be involved in the regulation of membrane expression...
  79. doi Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1
    Yukio Kato
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, 920 1192, Japan
    Pharm Res 27:832-40. 2010
    ..Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the physiologically important substrate of which is still unidentified. The aim of the present study was to examine physiological roles of OCTN1...
  80. doi Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia
    Elisabeth Kemter
    Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU Munich, Munich, Germany
    Am J Physiol Renal Physiol 298:F1405-15. 2010
    ..In conclusion, this novel viable mouse line with a missense Slc12a1 mutation exhibits most of the features of type I Bartter syndrome and may represent a new model for the study of this human disease...
  81. ncbi Calcium modulated signaling site in type 2 rod outer segment membrane guanylate cyclase (ROS-GC2)
    R M Goraczniak
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey, Stratford 08084, USA
    Biochem Biophys Res Commun 245:447-53. 1998
    The ROS-GC subfamily of membrane guanylate cyclases is at present represented by two members: ROS-GC1 and ROS-GC2. A unique functional feature of this subfamily is that it is intracellularly modulated in low Ca2+ concentration by ..
  82. doi Identification of single nucleotide polymorphisms in the bovine solute carrier family 11 member 1 (SLC11A1) gene and their association with infection by Mycobacterium avium subspecies paratuberculosis
    O Ruiz-Larrañaga
    Genetics, Physical Anthropology, and Animal Physiology Department, University of the Basque Country, Sarriena s n, 48940 Leioa, Bizkaia, Spain
    J Dairy Sci 93:1713-21. 2010
    ..Our results suggest that SNP c.1067C>G may be a potential causal variant, although functional studies are needed to assure this point...
  83. ncbi Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27
    S Verhaagh
    Department of Molecular Genetics H5, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands
    Genomics 55:209-18. 1999
    ..SLC22A1 and SLC22A2 localized to the same locus, demonstrating the conservation of the close physical linkage of these three organic cation transporter genes in mouse and human...
  84. pmc Identification of inhibitor concentrations to efficiently screen and measure inhibition Ki values against solute carrier transporters
    Xiaowan Zheng
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
    Eur J Pharm Sci 41:43-52. 2010
    ..This approach is advantageous in that minimal compound is needed to perform studies and accommodates compounds with low aqueous solubility...
  85. doi SLC6 neurotransmitter transporters: structure, function, and regulation
    Anders S Kristensen
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    Pharmacol Rev 63:585-640. 2011
    ..This review provides an update of these advances and their implications for the current understanding of the SLC6 NTTs...
  86. pmc The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species
    Pär J Höglund
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 28:1531-41. 2011
    ..The results provide foundation for overall classification of SLC genes and are valuable for annotation and prediction of substrates for the many SLCs that have not been tested in experimental transport assays...
  87. ncbi Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins
    R Zarrilli
    Section on Cell Regulation, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892
    Mol Endocrinol 3:1498-505. 1989
    ..The gene represented by the hML-7 cDNA has been assigned to human chromosome 10...
  88. pmc Role of an extracellular loop in determining the stoichiometry of Na+-HCO₃⁻ cotransporters
    Li Ming Chen
    Department of Biological Science, Key Laboratory of Molecular Biophysics of Ministry of Education, Huazhong University of Science and Technology School of Life Science and Technology, 1037 Luoyu Road, Wuhan, Hubei Province 430074, P R China
    J Physiol 589:877-90. 2011
    ..We hypothesize that putative EL4 either contributes to the substrate-binding vestibule or indirectly influences substrate binding by interacting with one or more transmembrane segments, thereby controlling the nature of transport...
  89. pmc Recruitment of SWI/SNF complex is required for transcriptional activation of the SLC11A1 gene during macrophage differentiation of HL-60 cells
    Yong Zhong Xu
    Division of Experimental Medicine, Department of Medicine, Montreal General Hospital Research Institute, McGill University, Montreal, Quebec H3G 1A4, Canada
    J Biol Chem 286:12839-49. 2011
    ..Our results demonstrated that recruitment of the SWI/SNF complex initiated Z-DNA formation and subsequently helped to transactivate the SLC11A1 gene...
  90. doi Distribution of Diego blood group alleles and identification of four novel mutations on exon 19 of SLC4A1 gene in the Chinese Han population by polymerase chain reaction sequence-based typing
    X G Xu
    Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China
    Vox Sang 100:317-21. 2011
    ..Here, we set up a polymerase chain reaction sequence-based typing (PCR-SBT) method for genotyping of Diego blood group alleles...
  91. pmc IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway
    Dongki Yang
    The Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 121:956-65. 2011
    ..They also have implications for WNK/SPAK kinase-regulated processes involved in systemic fluid homeostasis, hypertension, and cystic fibrosis...
  92. pmc The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death
    Eliana S Di Cairano
    Department of Molecular Science Applied to Biosystems, Universita degli Studi di Milano, 20134 Milan, Italy
    J Biol Chem 286:14007-18. 2011
    ....
  93. pmc Adenosine transport by plasma membrane monoamine transporter: reinvestigation and comparison with organic cations
    Mingyan Zhou
    University of Washington, Health Sciences Building, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 38:1798-805. 2010
    ..Functionally, PMAT should be viewed as a polyspecific organic cation transporter rather than an archetypical nucleoside transporter...
  94. pmc The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport
    David T Thwaites
    Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Br J Pharmacol 164:1802-16. 2011
    ....
  95. doi Glial solute carrier transporters in Drosophila and mice
    David E Featherstone
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Glia 59:1351-63. 2011
    ..This article lists and discusses SLC transporter family members that are expressed in both mouse and Drosophila glia, in an effort to provide a foundation for studies of glial SLC transporters using Drosophila as a model...
  96. ncbi Functional analysis of novel mutations in y(+)LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI)
    J Mykkänen
    Department of Medical Genetics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Hum Mol Genet 9:431-8. 2000
    ..This finding, together with the strong degree of conservation among all members of this family of amino acid transporters, indicates that residues L334 and G54 play a crucial role in the function of the y(+)LAT-1 transporter...
  97. pmc Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere
    T K Footz
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Genome Res 11:1053-70. 2001
    ....
  98. ncbi Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach
    A Fodor
    The Institute of Endocrinology, Diabetes and Metabolism, Rambam Medical Center, P O Box 9602, Haifa, 31096, Israel
    Diabetologia 50:121-30. 2007
    ..We examined a clinical model of ex vivo transdifferentiation of primary adult hepatocytes to insulin-secreting cells for the treatment of type 1 diabetes...
  99. ncbi Characteristics of L-carnitine import into heart cells
    Caroline Rigault
    Inserm U 866, LBMN, Dijon, Universite de Bourgogne, Faculté Gabriel, Dijon, France
    Biochimie 90:542-6. 2008
    ....
  100. ncbi [A difficult and complicated case study: neonatal intrahepatic cholestasis caused by citrin deficiency]
    Yuan Zong Song
    Department of Pediatrics, First Affiliated Hospital, Jinan University, Guangzhou 510632, China
    Zhongguo Dang Dai Er Ke Za Zhi 8:125-8. 2006
    ..SLC25A13 gene mutation analysis for the patient revealed a compound heterozygote of mutation 851del4 and 1638ins23 and therefore NICCD was definitely diagnosed...
  101. ncbi The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships
    J Geyer
    Institut fur Pharmakologie und Toxikologie, Justus Liebig Universitat Giessen, Frankfurter Strasse 107, 35392, Giessen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 372:413-31. 2006
    ....

Research Grants73

  1. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2010
    ..In GC1/GC2 double knockout rods, PDE6 failed to transport whereas transducin (T) and opsin kinase (GRK1) were unaffected...
  2. Defining Antigenic Targets of Autoimmune Sensorineural Hearing Loss
    Thomas E Carey; Fiscal Year: 2010
    ..It will lead to better diagnostic tests, better treatment through novel strategies based on knowledge, better surveillance of affected individuals and control of a process that destroys a person's ability to communicate. ..
  3. PHARMACOGENETICS OF MEMBRANE TRANSPORTERS
    Kathleen Giacomini; Fiscal Year: 2007
    ..These hypothesis generating studies will provide a framework for understanding the role of genetic variation in membrane transporters on clnical drug response. ..
  4. PHARMACOGENETICS OF MEMBRANE TRANSPORTERS
    Kathleen Giacomini; Fiscal Year: 2007
    ..These hypothesis generating studies will provide a framework for understanding the role of genetic variation in membrane transporters on clnical drug response. ..
  5. Structural Biology of the Apical Bile Acid Transporter.
    Peter Swaan; Fiscal Year: 2009
    ....
  6. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2010
    ....
  7. Studies of Erythrocyte Membrane Structure
    Philip Stewart Low; Fiscal Year: 2010
    ..Our research seeks to understand the molecular basis of each of these important functions, and where possible, to define clinical interventions that might enable treatment of conditions where the above processes malfunction. ..
  8. Studies of Erythrocyte Membrane Structure
    Philip Low; Fiscal Year: 2009
    ..Our research seeks to understand the molecular basis of each of these important functions, and where possible, to define clinical interventions that might enable treatment of conditions where the above processes malfunction. ..
  9. A Mouse Model of Acrodermatitis Enteropathica
    Glen Andrews; Fiscal Year: 2009
    ..In a global sense, these studies will contribute to our basic understanding of the molecular mechanisms governing the homeostasis of the essential metal zinc in mammals. ..
  10. A Mouse Model of Acrodermatitis Enteropathica
    Glen K Andrews; Fiscal Year: 2010
    ..In a global sense, these studies will contribute to our basic understanding of the molecular mechanisms governing the homeostasis of the essential metal zinc in mammals. ..
  11. Pathophysiology of thiamine-responsive anemia syndrome
    Ellis Neufeld; Fiscal Year: 2006
    ....
  12. TRANSPORT GENE EXPRESSION AND DRUG ACCUMULATION IN MILK
    Patrick McNamara; Fiscal Year: 2004
    ..The identification of the mammary epithelial carrier proteins, their genes, and factors that control their regulation are the ultimate, long-term goals of this research program. ..
  13. Mammalian Phototransduction: Role of cGMP and Calcium
    Wolfgang Baehr; Fiscal Year: 2007
    Photoreceptor guanylate cyclases (GC1 and GC2) produce cGMP, the internal messenger of phototransduction. Cations, mediated by Ca2+-binding proteins termed guanylate cyclase activating proteins (GCAPs), regulate their activities...
  14. Functional analysis of thyroidal iodide transporters
    MARY GILLAM; Fiscal Year: 2007
    ..Together, these studies will provide fundamental insights into the (patho)physiology of these two apical thyroid transporters and deepen our understanding of iodide transport in the thyroid. ..
  15. Substrate requirements of the bile acid transporter
    JAMES POLLI; Fiscal Year: 2007
    ..This systematic and progressive approach will serve as a prototypical method to elucidate the substrate requirements of other solute carrier (SLC) proteins. ..
  16. Substrate requirements of the bile acid transporter
    JAMES POLLI; Fiscal Year: 2009
    ..This systematic and progressive approach will serve as a prototypical method to elucidate the substrate requirements of other solute carrier (SLC) proteins. ..
  17. Frascati: mitochondrial transporter and erythropoiesis
    Barry Paw; Fiscal Year: 2007
    ..Insight into the function of the frascati gene will be directly relevant to our understanding of human disorders of iron deficiency anemia and iron-overload. ..
  18. Frascati: mitochondrial transporter and erythropoiesis
    Barry H Paw; Fiscal Year: 2010
    ..Insight into the function of the frascati gene will be directly relevant to our understanding of human disorders of iron deficiency anemia and iron-overload. ..
  19. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2009
    ....
  20. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2007
    ....
  21. Mouse Models of Vitamin Transport Defects
    Judith Fleming; Fiscal Year: 2004
    ..abstract_text> ..
  22. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  23. Mammalian metal transporters & Salmonella infection
    BOBBY CHERAYIL; Fiscal Year: 2006
    ..These studies will identify new aspects of the Salmonella-host cell interaction, shed light on the role of mammalian metal transporters in Salmonella infection, and suggest novel approaches to treating salmonellosis. ..
  24. Role of the Solute Carrier Gene Family in Hypertension
    Alanna C Morrison; Fiscal Year: 2010
    ....
  25. Mammalian Phototransduction: Role of cGMP and Calcium
    Wolfgang Baehr; Fiscal Year: 2006
    ..Additional questions concern the roles of GCAP2 and GC2 in phototransduction...
  26. Mammalian Phototransduction: Role of cGMP and Calcium
    Wolfgang Baehr; Fiscal Year: 2003
    ..Additional questions concern the roles of GCAP2 and GC2 in phototransduction...
  27. Adrenergic Receptor Linked ROS-GC Neurosensory Signaling
    Rameshwar Sharma; Fiscal Year: 2006
    ..ROS-GC exists in three forms: ROS-GC1, ROS-GC2 and ONE-GC...
  28. VIRUS & IMMUNE INJURY TO VESSEL WALL CELLS
    Harvey Friedman; Fiscal Year: 1993
    ..Purified gCl and gC2 bind C3b, and protect cell free virus from C'-mediated neutralization...
  29. GUANYLATE CYCLASE TRANSDUCTION SYSTEMS IN RETINA
    Rameshwar Sharma; Fiscal Year: 2002
    ..CRM2 to S100beta and CRM3 to GCAP2. A second form of ROS-GC, ROS-GC2, has been cloned from the retina, and is also Ca/2+ modulated, suggesting its linkage to phototransduction...
  30. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2007
    ..These studies will provide fundamental insights into the (patho)physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
  31. Frascati-mediated Iron Metabolism in Erythroblasts
    Barry Paw; Fiscal Year: 2007
    ..Specific Aim 2: A comparative transcriptome analysis of zebrafish embryos and mouse cells deficient for the frascati transporter will be conducted. ..
  32. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2003
    ..These studies will provide fundamental insights into the (patho) physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..