SLC23A1

Summary

Gene Symbol: SLC23A1
Description: solute carrier family 23 member 1
Alias: SLC23A2, SVCT1, YSPL3, solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, hSVCT1, sodium-dependent vitamin C transporter-1, solute carrier family 23 (ascorbic acid transporter), member 1, solute carrier family 23 (nucleobase transporters), member 1, solute carrier family 23 (nucleobase transporters), member 2, yolk sac permease-like molecule 3
Species: human
Products:     SLC23A1

Top Publications

  1. Timpson N, Forouhi N, Brion M, Harbord R, Cook D, Johnson P, et al. Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr. 2010;92:375-82 pubmed publisher
    ..We aimed to confirm the existence of an association between common variation at the SLC23A1 gene locus and circulating concentrations of L-ascorbic acid...
  2. Subramanian V, Sabui S, Marchant J, Said H. MicroRNA-103a regulates sodium-dependent vitamin C transporter-1 expression in intestinal epithelial cells. J Nutr Biochem. 2019;65:46-53 pubmed publisher
    ..Many studies have shown that hSVCT1 (product of the SLC23A1 gene) is expressed on the apical membrane of polarized enterocytes where it mediates AA absorption...
  3. Ravindran R, Sundaresan P, Krishnan T, Vashist P, Maraini G, Saravanan V, et al. Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract. Br J Ophthalmol. 2018;: pubmed publisher
    ..Genetic variants in vitamin C transporter proteins (SLC23A1), especially rs33972313, may provide evidence on a causal association of vitamin C with cataract...
  4. Dutta U, Rao S, Pidugu V, V S V, Bhattacherjee A, Bhowmik A, et al. Breakpoint mapping of a novel de novo translocation t(X;20)(q11.1;p13) by positional cloning and long read sequencing. Genomics. 2018;: pubmed publisher
    ..1 and on 20p13 between RASSF2 and SLC23A2 genes...
  5. Søgaard D, Lindblad M, Paidi M, Hasselholt S, Lykkesfeldt J, Tveden Nyborg P. In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain. Nutr Res. 2014;34:639-45 pubmed publisher
    ..and largely depends on the sodium-dependent vitC-specific transporters, sodium-dependent vitamin C transporter 1 (SVCT1) and sodium-dependent vitamin C transporter 2 (SVCT2)...
  6. Szarka A, Balogh T. In silico aided thoughts on mitochondrial vitamin C transport. J Theor Biol. 2015;365:181-9 pubmed publisher
    ..l-ascorbic acid, is imported by an active mechanism requiring two sodium-dependent vitamin C transporters (SVCT1 and SVCT2). The oxidized form, dehydroascorbate is taken up by different members of the GLUT family...
  7. Jeckelmann J, Harder D, Ucurum Z, Fotiadis D. 2D and 3D crystallization of a bacterial homologue of human vitamin C membrane transport proteins. J Struct Biol. 2014;188:87-91 pubmed publisher
    ..protein (UraDp) with 29% of amino acid sequence identity to the human sodium-dependent vitamin C transporter 1 (SVCT1)...
  8. Zheleznyakova G, Nilsson E, Kiselev A, Maretina M, Tishchenko L, Fredriksson R, et al. Methylation levels of SLC23A2 and NCOR2 genes correlate with spinal muscular atrophy severity. PLoS ONE. 2015;10:e0121964 pubmed publisher
    ..designed as "targets", as well as the nearest CpG sites in regulatory regions of ARHGAP22, CDK2AP1, CHML, NCOR2, SLC23A2 and RPL9 in three groups of SMA patients...
  9. Kobylecki C, Afzal S, Davey Smith G, Nordestgaard B. Genetically high plasma vitamin C, intake of fruit and vegetables, and risk of ischemic heart disease and all-cause mortality: a Mendelian randomization study. Am J Clin Nutr. 2015;101:1135-43 pubmed publisher
    ..We used a Mendelian randomization approach and genotyped for solute carrier family 23 member 1 (SLC23A1) rs33972313 in the sodium-dependent vitamin C transporter 1 in 97,203 white individuals of ..

More Information

Publications63

  1. Maldonado M, Inostroza E, Peña E, Moncada N, Mardones L, Medina J, et al. Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy. Free Radic Biol Med. 2017;108:655-667 pubmed publisher
    ..organism, they also acquire AA from extracellular sources through the sodium-coupled ascorbic acid transporter-1 (SVCT1)...
  2. Silva Alvarez C, Salazar K, Cisternas P, Martinez F, Liour S, Jara N, et al. Apical Polarization of SVCT2 in Apical Radial Glial Cells and Progenitors During Brain Development. Mol Neurobiol. 2017;54:5449-5467 pubmed publisher
    ..transport the reduced form of vitamin C, ascorbic acid (AA), using sodium-dependent ascorbic acid cotransporters (SVCT1 or SVCT2)...
  3. Pinazo Duran M, Shoaie Nia K, Sanz González S, Raga Cervera J, Garcia Medina J, López Gálvez M, et al. Identification of new candidate genes for retinopathy in type 2 diabetics. Valencia Study on Diabetic Retinopathy (VSDR). Report number 3. Arch Soc Esp Oftalmol. 2018;93:211-219 pubmed publisher
    ..examination, and blood collection (to analyse the DNA for determining the gene expression (TP53, MMP9, and SLC23A2) in the study groups. Statistical analyses were performed using the SPSS v22.0 program...
  4. Casabonne D, Gracia E, Espinosa A, Bustamante M, Benavente Y, Robles C, et al. Fruit and vegetable intake and vitamin C transporter gene (SLC23A2) polymorphisms in chronic lymphocytic leukaemia. Eur J Nutr. 2017;56:1123-1133 pubmed publisher
    ..that variations in vitamin C dietary intake as well as in genetic variability in vitamin C transporter gene SLC23A2 could explain some inconsistencies in the literature...
  5. Subramanian V, Srinivasan P, Said H. Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure. Am J Physiol Cell Physiol. 2016;311:C129-35 pubmed publisher
    ..We also observed significant epigenetic changes (histone modifications) in the Slc23a2 gene (reduction in H3K4me3 level and an increase in H3K27me3 level) in the alcohol-exposed 266-6 cells...
  6. Forman K, Martinez F, Cifuentes M, Bertinat R, Salazar K, Nualart F. Aging Selectively Modulates Vitamin C Transporter Expression Patterns in the Kidney. J Cell Physiol. 2017;232:2418-2426 pubmed publisher
    ..the kidney, vitamin C is reabsorbed from the glomerular ultrafiltrate by sodium-vitamin C cotransporter isoform 1 (SVCT1) located in the brush border membrane of the proximal tubules...
  7. Saitoh Y, Nakawa A, Tanabe T, Akiyama T. The influence of cellular senescence on intracellular vitamin C transport, accumulation, and function. Mol Cell Biochem. 2018;446:209-219 pubmed publisher
    ..the molecules related to VC accumulation, the mRNA and protein expressions of sodium-dependent VC transporter 2 (SLC23A2) were increased in senescent cells...
  8. Liang W, Johnson D, Jarvis S. Vitamin C transport systems of mammalian cells. Mol Membr Biol. 2001;18:87-95 pubmed
    ..L-ascorbic acid enters cells via Na+-dependent systems, and two isoforms of these transporters (SVCT1 and SVCT2) have recently been cloned from humans and rats...
  9. Tsukaguchi H, Tokui T, Mackenzie B, Berger U, Chen X, Wang Y, et al. A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999;399:70-5 pubmed
    ..Here we describe the isolation of two L-ascorbic acid transporters, SVCT1 and SVCT2, from rat complementary DNA libraries, as the first step in investigating the importance of L-ascorbic ..
  10. Mardones L, Zuniga F, Villagrán M, Sotomayor K, Mendoza P, Escobar D, et al. Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells. Free Radic Biol Med. 2012;52:1874-87 pubmed publisher
    ..Rat hepatocytes expressed the Na(+)-coupled ascorbic acid transporter-1 (SVCT1), while hepatoma cells expressed the transporters SVCT1 and SVCT2...
  11. Varma S, Campbell C, Kuo S. Functional role of conserved transmembrane segment 1 residues in human sodium-dependent vitamin C transporters. Biochemistry. 2008;47:2952-60 pubmed publisher
    ..Mutating any of the four conserved histidine residues (His51, 147, 210, or 354) in hSVCT1 to alanine did not affect the apical membrane localization in polarized MDCK cells...
  12. Steiling H, Longet K, Moodycliffe A, Mansourian R, Bertschy E, Smola H, et al. Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress. Free Radic Biol Med. 2007;43:752-62 pubmed
    Two sodium-dependent vitamin C transporter isoforms (SVCT1 and SVCT2) were identified as ascorbic acid transporters, but their roles in skin have, as yet, not been elucidated...
  13. Boyer J, Campbell C, Sigurdson W, Kuo S. Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. Biochem Biophys Res Commun. 2005;334:150-6 pubmed
    Messenger RNA of homologous sodium-vitamin C cotransporters, SVCT1 and SVCT2, were found in the intestine. Studies using cultured intestinal cells suggested an apical presence of SVCT1 but the function of SVCT2 was unknown...
  14. MacDonald L, Thumser A, Sharp P. Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line. Br J Nutr. 2002;87:97-100 pubmed
    ..b>SVCT1 is thought to be the predominant transporter in the intestine...
  15. Kang J, Kim H, Jung D, Kim J, Mun G, Kim Y, et al. Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane. J Invest Dermatol. 2007;127:698-706 pubmed
    ..Taken together, vitamin C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production. ..
  16. Macias R, Hierro C, de Juan S, Jimenez F, González San Martín F, Marin J. Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases. Br J Nutr. 2011;106:1814-25 pubmed publisher
    ..Expression of Na-dependent vitamin C transporters (SVCT; SLC23A1 and SLC23A2) during long-term oxidative stress occurring in several chronic liver diseases may determine the antioxidant ..
  17. Luo S, Wang Z, Kansara V, Pal D, Mitra A. Activity of a sodium-dependent vitamin C transporter (SVCT) in MDCK-MDR1 cells and mechanism of ascorbate uptake. Int J Pharm. 2008;358:168-76 pubmed publisher
    ..Uptake of AA was found to be saturable with a K(m) of 83.2muM and V(max) of 94.2pmol/min/mg protein for SVCT1. The process was pH, sodium, temperature, and energy-dependent...
  18. Faaland C, Race J, Ricken G, Warner F, Williams W, Holtzman E. Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters. Biochim Biophys Acta. 1998;1442:353-60 pubmed
    ..The human and pig homologs are 95% similar. YSPL3 encodes a 598-residue protein with a 3 kb transcript that is expressed only in kidney and liver...
  19. Hogue D, Ling V. A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. Genomics. 1999;59:18-23 pubmed
    ..Fluorescence in situ hybridization localized the gene (HGMW-approved symbol SLC23A1) to human chromosome 20p13...
  20. Wade K, Forouhi N, Cook D, Johnson P, McConnachie A, Morris R, et al. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. Am J Clin Nutr. 2015;101:202-9 pubmed publisher
    ..L-ascorbic acid and 10 cardiometabolic traits by using a single nucleotide polymorphism in the solute carrier family 23 member 1 (SLC23A1) gene (rs33972313) associated with circulating L-ascorbic acid concentrations...
  21. Muñoz A, Villagrán M, Guzmán P, Solíz C, Gatica M, Aylwin C, et al. Cis-regulatory elements involved in species-specific transcriptional regulation of the SVCT1 gene in rat and human hepatoma cells. Free Radic Biol Med. 2015;85:183-96 pubmed publisher
    ..stress in cells from species that differ in their capacity to synthesize vitamin C, with a marked decrease in SVCT1 mRNA and protein levels in rat hepatoma cells that was not observed in human hepatoma cells...
  22. Varma S, Sobey K, Campbell C, Kuo S. Hierarchal contribution of N- and C-terminal sequences to the differential localization of homologous sodium-dependent vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. Biochemistry. 2009;48:2969-80 pubmed publisher
    ..Domain swaps, deletions, insertions, and point mutations were performed on EGFP-tagged hSVCT1 and hSVCT2 plasmids...
  23. Velho A, Jarvis S. Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting. Exp Cell Res. 2009;315:2312-21 pubmed publisher
    The Na(+)-dependent transporters, hSVCT1 and hSVCT2, were assessed in COS-1 cells for their membrane topology...
  24. Subramanian V, Subramanya S, Ghosal A, Marchant J, Harada A, Said H. Modulation of function of sodium-dependent vitamin C transporter 1 (SVCT1) by Rab8a in intestinal epithelial cells: studies utilizing Caco-2 cells and Rab8a knockout mice. Dig Dis Sci. 2013;58:641-9 pubmed publisher
    ..expresses two sodium-dependent vitamin C transporters (hSVCT-1 and -2) that mediate cellular AA transport, with hSVCT1 targeting to the apical membrane of polarized epithelia...
  25. Reidling J, Rubin S. Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regulation in liver epithelial cells. J Nutr Biochem. 2011;22:344-50 pubmed publisher
    ..Therefore, we characterized the minimal promoter regions of hSVCT1 and 2 in cultured human liver epithelial cells (HepG2) and examined the effects of ascorbic acid deprivation and ..
  26. de Jong T, Jochens A, Jockel Schneider Y, Harks I, Dommisch H, Graetz C, et al. SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis. J Clin Periodontol. 2014;41:531-40 pubmed publisher
    Identification of variants within genes SLC23A1 and SLC23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (CP). Employment of three independent case-control samples of AgP (I...
  27. Flach C, Qadri F, Bhuiyan T, Alam N, Jennische E, Holmgren J, et al. Differential expression of intestinal membrane transporters in cholera patients. FEBS Lett. 2007;581:3183-8 pubmed
    ..Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively...
  28. Michels A, Hagen T. Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1. Am J Physiol Cell Physiol. 2009;297:C1220-7 pubmed publisher
    ..Despite the importance of this protein, little is known about regulation of the gene encoding SVCT1, Slc23a1. In this study, we present the first investigation of the transcriptional regulation of human Slc23a1, ..
  29. Reidling J, Subramanian V, Dahhan T, Sadat M, Said H. Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008;295:G1217-27 pubmed publisher
    Humans use two sodium-ascorbate cotransporters (hSVCT1 and hSVCT2) for transporting the dietary essential micronutrient ascorbic acid, the reduced and active form of vitamin C...
  30. Nualart F, Castro T, Low M, Henriquez J, Oyarce K, Cisternas P, et al. Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development. Histochem Cell Biol. 2013;139:233-47 pubmed publisher
    Isoform 1 of the sodium-vitamin C co-transporter (SVCT1) is expressed in the apical membrane of proximal tubule epithelial cells in adult human and mouse kidneys...
  31. Senthilkumari S, Talwar B, Dharmalingam K, Ravindran R, Jayanthi R, Sundaresan P, et al. Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting. Exp Eye Res. 2014;124:24-30 pubmed publisher
    ..are influenced by Single Nucleotide Polymorphisms (SNPs) in sodium-dependent vitamin C transporter genes (SLC23A1 and SLC23A2)...
  32. Maulén N, Henríquez E, Kempe S, Carcamo J, Schmid Kotsas A, Bachem M, et al. Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells. J Biol Chem. 2003;278:9035-41 pubmed
    ..and reverse transcriptase-PCR analysis indicated that CaCo-2 cells express the sodium-ascorbate co-transporters SVCT1 and SVCT2, the dehydroascorbic acid transporters GLUT1 and GLUT3, and a third dehydroascorbic acid transporter ..
  33. Subramanian V, Srinivasan P, Wildman A, Marchant J, Said H. Molecular mechanism(s) involved in differential expression of vitamin C transporters along the intestinal tract. Am J Physiol Gastrointest Liver Physiol. 2017;312:G340-G347 pubmed publisher
    ..of expression of hepatocyte nuclear factor 1α and specificity protein 1, which drive transcription of the Slc23a1 and Slc23a2 promoters, respectively, and found them to be markedly lower in the colon...
  34. Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton C, Hediger M. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochem Biophys Res Commun. 2000;267:488-94 pubmed
    ..We have mapped the SLC23A2 gene (coding for SVCT1) to human chromosome 5 in band 5q31.2-31...
  35. Daruwala R, Song J, Koh W, Rumsey S, Levine M. Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. FEBS Lett. 1999;460:480-4 pubmed
    Two sodium-dependent vitamin C transporters, hSVCT1 and hSVCT2, were cloned from a human kidney cDNA library. hSVCT1 had a 1797 bp open reading frame encoding a 598 amino acid polypeptide...
  36. Hirai T, Fukui Y, Motojima K. PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine. Biol Pharm Bull. 2007;30:2185-90 pubmed
    ..levels of seven nutrient/drug transporters (Abcd3, Octn2/Slc22a5, FATP2/Slc27a2, Slc22a21, Mct13/Slc16a13, Slc23a1 and Bcrp/Abcg2) in the intestine were up-regulated and the expression level of one (Mrp1/Abcc1) was down-..
  37. Subramanian V, Nabokina S, Patton J, Marchant J, Moradi H, Said H. Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis. Am J Physiol Gastrointest Liver Physiol. 2013;304:G1079-86 pubmed publisher
    The human sodium-dependent vitamin C transporter 1 (hSVCT1) contributes to cellular uptake of ascorbic acid (AA)...
  38. Johnston L, Laverty G. Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture. Comp Biochem Physiol A Mol Integr Physiol. 2007;146:327-34 pubmed
    ..Chicken-specific primers to an EST homolog of the human vitamin C transporter SVCT1 (SLC23A1) were designed and used to probe transporter expression in these cells...
  39. Erichsen H, Peters U, Eck P, Welch R, Schoen R, Yeager M, et al. Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer. 2008;60:652-9 pubmed publisher
    ..Vitamin C transport is facilitated by membrane bound sodium-dependent transporters, SVCT1 (encoded by SLC23A1) and SVCT2 (encoded by SLC23A2)...
  40. Erichsen H, Engel S, Eck P, Welch R, Yeager M, Levine M, et al. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. Am J Epidemiol. 2006;163:245-54 pubmed
    ..There are two sodium-dependent membrane transporters encoded by SLC23A1 and SLC23A2, which have key roles in human vitamin C metabolism and which control dietary uptake, reabsorption, ..
  41. Subramanian V, Sabui S, Moradi H, Marchant J, Said H. Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms. Biochim Biophys Acta Biomembr. 2018;1860:556-565 pubmed publisher
    ..Inhibition of SVCT-1 and SVCT-2 occurred at least in part at the transcriptional level as promoter activity of SLC23A1 and SLC23A2 was attenuated following LPS treatment...
  42. Erichsen H, Eck P, Levine M, Chanock S. Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2). J Nutr. 2001;131:2623-7 pubmed
    ..In this paper, we report the complete sequencing and gene structure of SLC23A2, the gene encoding SVCT1...
  43. Mackenzie B, Illing A, Hediger M. Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1. Am J Physiol Cell Physiol. 2008;294:C451-9 pubmed
    ..and renal reabsorption of the vitamin is mediated by the epithelial apical L-ascorbic acid cotransporter SVCT1 (SLC23A1)...
  44. Subramanian V, Marchant J, Boulware M, Said H. A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia. J Biol Chem. 2004;279:27719-28 pubmed
    The human sodium-dependent vitamin C transporter (hSVCT1) mediates sodium-dependent cellular uptake of the essential micronutrient l-ascorbic acid (vitamin C)...
  45. Kuo S, Wang L, Yu S, Campbell C, Valiyaparambil S, Rance M, et al. The N-terminal basolateral targeting signal unlikely acts alone in the differential trafficking of membrane transporters in MDCK cells. Biochemistry. 2013;52:5103-5116 pubmed publisher
    ..and transport assays, that the N-terminus of sodium-dependent vitamin C transporter 2 (SVCT2) can redirect apical SVCT1 to the basolateral membrane...
  46. Cahill L, El Sohemy A. Vitamin C transporter gene polymorphisms, dietary vitamin C and serum ascorbic acid. J Nutrigenet Nutrigenomics. 2009;2:292-301 pubmed publisher
    Vitamin C transporter proteins SVCT1 and SVCT2 are required for the absorption and transport of vitamin C in humans...
  47. Hediger M. New view at C. Nat Med. 2002;8:445-6 pubmed
  48. Amir Shaghaghi M, Bernstein C, Serrano León A, El Gabalawy H, Eck P. Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease. Am J Clin Nutr. 2014;99:378-83 pubmed publisher
    ..The role of ascorbate transporters in IBD remains to be determined. SLC23A1 is a major ascorbate transporter in the intestinal tract, and some of its genetic variants have been associated ..
  49. Rajan D, Huang W, Dutta B, Devoe L, Leibach F, Ganapathy V, et al. Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. Biochem Biophys Res Commun. 1999;262:762-8 pubmed
    ..Northern blot analysis shows that SVCT2-specific transcripts are present in heart, brain, placenta, and liver and is absent in lung and skeletal muscle. The size of the principal transcript is approximately 7.5 kb. ..
  50. Liang W, Johnson D, Ma L, Jarvis S, Wei Jun L. Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected]. Am J Physiol Cell Physiol. 2002;283:C1696-704 pubmed
    Protein kinase C (PKC) regulation of l-ascorbic acid transport mediated by the Na+/ascorbic acid transporters, hSVCT1 and hSVCT2, expressed in COS-1 cells was studied using recombinant carboxyl-terminal V5 epitope-tagged forms of the ..
  51. Saitoh Y, Morishita A, Mito S, Tsujiya T, Miwa N. Senescence-induced increases in intracellular oxidative stress and enhancement of the need for ascorbic acid in human fibroblasts. Mol Cell Biochem. 2013;380:129-41 pubmed publisher
    ..Therefore, our results also indicate that AsA could play an important role in regulating the intracellular ROS levels in senescent cells and that the need for AsA is enhanced by cellular senescence. ..
  52. Wang H, Dutta B, Huang W, Devoe L, Leibach F, Ganapathy V, et al. Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant. Biochim Biophys Acta. 1999;1461:1-9 pubmed
    We report here on the cloning and functional characterization of human Na(+)-dependent vitamin C transporter 1 (SVCT1)...
  53. Subramanian V, Marchant J, Reidling J, Said H. N-Glycosylation is required for Na+-dependent vitamin C transporter functionality. Biochem Biophys Res Commun. 2008;374:123-7 pubmed publisher
    The human sodium-dependent vitamin C transporters (hSVCT1 and hSVCT2) mediate cellular uptake of ascorbic acid...
  54. Wright M, Andreotti G, Lissowska J, Yeager M, Zatonski W, Chanock S, et al. Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland. Eur J Cancer. 2009;45:1824-30 pubmed publisher
    ..We investigated whether single nucleotide polymorphisms (SNPs) in SLC23A1 and SLC23A2--genes that encode key ascorbic acid transport proteins--affect gastric cancer risk in 279 incident cases and 414 ..