SLC22A3

Summary

Gene Symbol: SLC22A3
Description: solute carrier family 22 member 3
Alias: EMT, EMTH, OCT3, solute carrier family 22 member 3, EMT organic cation transporter 3, extraneuronal monoamine transporter, organic cation transporter 3, solute carrier family 22 (extraneuronal monoamine transporter), member 3, solute carrier family 22 (organic cation transporter), member 3
Species: human
Products:     SLC22A3

Top Publications

  1. Kekuda R, Prasad P, Wu X, Wang H, Fei Y, Leibach F, et al. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998;273:15971-9 pubmed
    ..This potential-sensitive organic cation transporter, designated as OCT3, represents a new member of the OCT gene family.
  2. Lazar A, Walitza S, Jetter A, Gerlach M, Warnke A, Herpertz Dahlmann B, et al. Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2008;11:35-48 pubmed
    ..The extraneuronal monoamine transporter, EMT (SLC22A3), is implicated in non-neuronal termination of noradrenergic signalling in the ..
  3. Eeles R, Kote Jarai Z, Giles G, Olama A, Guy M, Jugurnauth S, et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet. 2008;40:316-21 pubmed publisher
    ..7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3. ..
  4. Tregouet D, Konig I, Erdmann J, Munteanu A, Braund P, Hall A, et al. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet. 2009;41:283-5 pubmed publisher
    We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study...
  5. Cui R, Okada Y, Jang S, Ku J, Park J, Kamatani Y, et al. Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population. Gut. 2011;60:799-805 pubmed publisher
    ..We identified a novel locus on 6q26-q27 region (rs7758229 in SLC22A3, p = 7.92 × 10??, OR of 1.28) that was significantly associated with distal colon cancer...
  6. Shaw S, Cheng S, Cupples L, Larson M, McCabe E, Ngwa J, et al. Genetic and clinical correlates of early-outgrowth colony-forming units. Circ Cardiovasc Genet. 2011;4:296-304 pubmed publisher
    ..3 × 10(-7)) and at the SLC22A3-LPAL2-LPA locus (P = 4.9 × 10(-7)), a previously replicated susceptibility locus for myocardial infarction...
  7. Mazzio E, Lewis C, Soliman K. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death. Cancer Genomics Proteomics. 2017;14:409-425 pubmed
    ..which, heretofore, lack functional pathway mapping, but are capable of driving epithelial-mesenchymal transition (EMT), cell survival, proliferation, metastasis and drug resistance...
  8. Cai H, Su S, Li Y, Zeng H, Zhu Z, Guo J, et al. Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways. J Ethnopharmacol. 2018;212:153-165 pubmed publisher
    ..Furthermore, SM extracts prevent epithelial-mesenchymal transition (EMT) of human renal tubular epithelial (HK-2) cell by inhibiting NADPH oxidase/ROS/ERK and TGF-?/Smad signaling ..
  9. Yi P, Niu H, Gao Q, Wang F, Jia W, Chen Z, et al. [Pathologic features on gonadal changes of sexual developmental disorders in children]. Zhonghua Bing Li Xue Za Zhi. 2018;47:531-535 pubmed publisher
    ..SALL4 and OCT3/4 were positive in 3 cases. Inhibin highlighted interstitial Leydig cells in 2 cases...

More Information

Publications145 found, 100 shown here

  1. Lin C, Liu L, Ou L, Pan S, Lin C, Wei Y. Role of mitochondrial function in the invasiveness of human colon cancer cells. Oncol Rep. 2018;39:316-330 pubmed publisher
    ..on energy metabolism, reactive oxygen species, protein expression levels of epithelial-mesenchymal transition (EMT) markers and invasive activity of CRC cells...
  2. Shi C, Yang X, Bu X, Hou N, Chen P. Alpha B-crystallin promotes the invasion and metastasis of colorectal cancer via epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2017;489:369-374 pubmed publisher
    ..IHC) was employed to examine CRYAB protein expression and the markers of epithelial-mesenchymal transition (EMT), such as E-cadherin, fibronectin, vimentin, and slug, in tumor tissues from nude mice and clinical invasive CRC ..
  3. Vallejo Díez S, Fleischer A, Martín Fernández J, Sanchez Gilabert A, Bachiller D. Generation of two induced pluripotent stem cells lines from a Mucopolysaccharydosis IIIB (MPSIIIB) patient. Stem Cell Res. 2018;33:180-184 pubmed publisher
    ..Cells were reprogrammed with OriP/EBNA1-based episomal plasmids containing: OCT3/4, SOX2, KLF4, L-MYC, LIN28, BCL-xL and shp53...
  4. Cai H, Su S, Qian D, Guo S, Tao W, Cong X, et al. Renal protective effect and action mechanism of Huangkui capsule and its main five flavonoids. J Ethnopharmacol. 2017;206:152-159 pubmed publisher
    ..renal failure (CRF) rats and its mechanism against high glucose-induced epithelial to mesenchymal transition (EMT) in renal tubular epithelial cells (HK-2) of its bioactive components...
  5. Afrin S, Giampieri F, Gasparrini M, Forbes Hernández T, Cianciosi D, Reboredo Rodriguez P, et al. The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability. Food Funct. 2018;9:2158-2170 pubmed publisher
    ..Dose-dependently, MH reduced the migration and invasion (MMP-2 and MMP-9) ability, and concurrently regulated EMT-related markers (E cadherin, N cadherin, and β-catenin) in both cell types...
  6. Tajbakhsh A, Pasdar A, Rezaee M, Fazeli M, Soleimanpour S, Hassanian S, et al. The current status and perspectives regarding the clinical implication of intracellular calcium in breast cancer. J Cell Physiol. 2017;: pubmed publisher
    ..protein kinase II (CaMKII), mitogen-activated protein kinase (MAPK), epithelial-mesenchymal transition (EMT), vascular endothelial growth factor (VEGF), poly (ADP-Ribose) polymerase-1 (PARP1), estrogen, and estrogen ..
  7. Slowikowska Hilczer J, Szarras Czapnik M, Wolski J, Oszukowska E, Hilczer M, Jakubowski L, et al. The risk of neoplasm associated with dysgenetic testes in prepubertal and pubertal/adult patients. Folia Histochem Cytobiol. 2015;53:218-26 pubmed publisher
    ..4%. All gonadal tissues were subjected to immunohistochemical evaluation with antibodies against PLAP and OCT3/4 (markers of malignant germ cells, but also foetal multipotent germ cells), while gonads of prepubertal patients ..
  8. Janaki Ramaiah M, Lavanya A, Honarpisheh M, Zarea M, Bhadra U, Bhadra M. MiR-15/16 complex targets p70S6 kinase 1 and controls cell proliferation in MDA-MB-231 breast cancer cells. Gene. 2014;552:255-64 pubmed publisher
    ..Further, these microRNAs also inhibit epithelial to mesenchymal transition (EMT) by targeting key proteins such as Twist1 and EZH2 clearly demonstrating its crucial role in controlling cell ..
  9. Ebbing E, Steins A, Fessler E, Stathi P, Lesterhuis W, Krishnadath K, et al. Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition. Gastroenterology. 2017;153:63-76.e14 pubmed publisher
    ..Cells were analyzed for markers of the epithelial to mesenchymal transition (EMT) using flow cytometry, immunofluorescence, and quantitative reverse transcription polymerase chain reaction...
  10. D Almeida O, Mothar O, Bondzie E, Lieumo Y, Tagne L, Gupta S, et al. Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells. BMC Cancer. 2019;19:136 pubmed publisher
    ..The expression of encapsulated miR-200c contributes to the inhibition/activation of Kras, EMT, Hippo, regulatory pathways and blockers of metastasis...
  11. Li Y, Gong Y, Ning X, Peng D, Liu L, He S, et al. Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis. J Exp Clin Cancer Res. 2018;37:276 pubmed publisher
    ..that CLDN7 had negative effects in cancer-associated signaling pathways and (epithelial-mesenchymal transition) EMT-related pathways. These results were validated by qRT-PCR, Western blot and immunostaining...
  12. Gouignard N, Maccarana M, Strate I, von Stedingk K, Malmstrom A, Pera E. Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin. Dis Model Mech. 2016;9:607-20 pubmed publisher
    ..it impairs the correct activation of transcription factors involved in the epithelial-mesenchymal transition (EMT) and reduces the extent of NC cell migration, which leads to a decrease in NC-derived craniofacial skeleton, ..
  13. Lou K, Li Z, Wang P, Liu Z, Chen Y, Wang X, et al. Long non-coding RNA BANCR indicates poor prognosis for breast cancer and promotes cell proliferation and invasion. Eur Rev Med Pharmacol Sci. 2018;22:1358-1365 pubmed publisher
    ..was used to detect the changes in expressions of apoptosis-related proteins, epithelial-mesenchymal transition (EMT)-related proteins and matrix metalloproteinases (MMPs) after knockdown of BANCR...
  14. St John M. Inflammatory mediators drive metastasis and drug resistance in head and neck squamous cell carcinoma. Laryngoscope. 2015;125 Suppl 3:S1-11 pubmed publisher
    ..in epithelial intercellular adhesion; its downregulation is a hallmark of the epithelial-to-mesenchymal transition (EMT) (an essential process during tumor progression); and it is associated with invasion, metastasis, and decreased ..
  15. Csak T, Bala S, Lippai D, Kodys K, Catalano D, Iracheta Vellve A, et al. MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. PLoS ONE. 2015;10:e0129251 pubmed publisher
    ..transduction and vimentin, a mesenchymal marker and indirect indicator of epithelial-to-mesenchymal transition (EMT) in miR-155 KO mice...
  16. Demirkan B. The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment. J Clin Med. 2013;2:264-82 pubmed publisher
    ..Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) effectors play critical roles during embryonic development, postnatal ..
  17. Lee J, Kim J, Kim J, Chang J, Kim S, Park J, et al. AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition. Am J Physiol Renal Physiol. 2013;304:F686-97 pubmed publisher
    The epithelial-mesenchymal transition (EMT) is a novel mechanism that promotes renal fibrosis...
  18. Franke F, Muller J, Abal M, Medina E, Nitsche U, Weidmann H, et al. The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Cell Mol Gastroenterol Hepatol. 2019;7:33-53 pubmed publisher
    ..Epithelial-mesenchymal transition (EMT) was analyzed by quantitative reverse-transcription polymerase chain reaction, immunoblotting, immunofluorescence ..
  19. Saito A, Ooki A, Nakamura T, Onodera S, Hayashi K, Hasegawa D, et al. Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model. Stem Cell Res Ther. 2018;9:12 pubmed publisher
    ..cases of CCD patient-derived induced pluripotent stem cells (CCD-iPSCs) were generated using retroviral vectors (OCT3/4, SOX2, KLF4, and c-MYC) or a Sendai virus SeVdp vector (KOSM302L)...
  20. Han M, Zhao Y, Tan C, Xiong Y, Wang W, Wu F, et al. Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells. Acta Pharmacol Sin. 2016;37:1606-1622 pubmed publisher
    ..The expression of EMT-associated transcription factors was measured with Western blotting or q-PCR...
  21. Shen X, Cheng S, Peng Y, Song H, Li H. Attenuation of early liver fibrosis by herbal compound "Diwu Yanggan" through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. BMC Complement Altern Med. 2014;14:418 pubmed publisher
    ..of the degree of fibrosis, DWYG treatment provoked the reversal of epithelial-to-mesenchymal transition (EMT) to mesenchymal-to-epithelial transition (MET) in the fibrotic liver tissues, which was characterized with the up-..
  22. Chiu S, Chiu T, Huang S, Chang S, Chen S, Pang C, et al. Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells. BMC Complement Altern Med. 2017;17:523 pubmed publisher
    ..BP also suppressed the migration and invasion of these cells, probably by modulating EMT-related genes...
  23. Zeng H, Wang Y, Gu Y, Wang J, Zhang H, Gao H, et al. Polydatin attenuates reactive oxygen species-induced airway remodeling by promoting Nrf2-mediated antioxidant signaling in asthma mouse model. Life Sci. 2019;218:25-30 pubmed publisher
    Reactive oxygen species (ROS) and epithelial-mesenchymal transition (EMT) play a critical role in transforming growth factor (TGF)-β1-mediated fibrotic airway remodeling in asthma...
  24. Khan P, Manna A, Saha S, Mohanty S, Mukherjee S, Mazumdar M, et al. Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug. BMC Cancer. 2016;16:39 pubmed publisher
    ..It has been acknowledged that aberrant activation of epithelial-to-mesenchymal transition (EMT) program, endows cancer cells with metastatic competence for which E-cadherin switch is a well-established hallmark...
  25. Li C, Li Q, Cai Y, He Y, Lan X, Wang W, et al. Overexpression of angiopoietin 2 promotes the formation of oral squamous cell carcinoma by increasing epithelial-mesenchymal transition-induced angiogenesis. Cancer Gene Ther. 2016;23:295-302 pubmed publisher
    ..The initial step in the metastasis and transition of tumors is epithelial-mesenchymal transition (EMT)-induced angiogenesis, which can be mediated by angiopoietin 2 (ANG2), a key regulatory factor in angiogenesis...
  26. Zac Varghese S, Trapp S, Richards P, Sayers S, Sun G, Bloom S, et al. The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. Dis Model Mech. 2014;7:1275-86 pubmed publisher
    ..mice suggested that a subpopulation of proglucagon-expressing cells undergo epithelial-mesenchymal transition (EMT) to become smooth-muscle-like cells...
  27. Gunasekaran V, Nishi K, Sivakumar D, Sivaraman T, Mathan G. Identification of 2,4-dihydroxy-5-pyrimidinyl imidothiocarbomate as a novel inhibitor to Y box binding protein-1 (YB-1) and its therapeutic actions against breast cancer. Eur J Pharm Sci. 2018;116:2-14 pubmed publisher
    ..of various proteins involved in cancer progression, apoptosis, cell cycle, epithelial to mesenchymal transition (EMT) and drug resistance...
  28. Li J, Yang Y, Liu Q, Zhou Z, Pan S, He Z, et al. The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells. Drug Des Devel Ther. 2015;9:1027-62 pubmed publisher
    ..to investigate the effects of Danu on the growth, apoptosis, autophagy, and epithelial-to-mesenchymal transition (EMT) and the molecular mechanisms in human breast cancer MCF7 and MDA-MB-231 cells...
  29. Baek S, Ko J, Lee J, Kim C, Lee H, Nam D, et al. Ginkgolic Acid Inhibits Invasion and Migration and TGF-?-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation. J Cell Physiol. 2017;232:346-354 pubmed publisher
    Epithelial-to-mesenchymal transition (EMT) is a critical cellular phenomenon regulating tumor metastases...
  30. Jagadish N, Gupta N, Agarwal S, Parashar D, Sharma A, Fatima R, et al. Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. Tumour Biol. 2016;37:13101-13110 pubmed
    ..understand the role of SPAG9 at molecular level in apoptosis, cell cycle, and epithelial-to-mesenchymal transition (EMT) signaling...
  31. Mahmood M, Reid D, Ward C, Muller H, Knight D, Sohal S, et al. Transforming growth factor (TGF) ?1 and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis. Respirology. 2017;22:133-140 pubmed publisher
    ..been implicated in the pathogenesis of COPD, and in particular a process called epithelial mesenchymal transition (EMT), which may well be an intermediatory between smoking and both airway fibrosis and lung cancer...
  32. Sannino G, Armbruster N, Bodenhöfer M, Haerle U, Behrens D, Buchholz M, et al. Role of BCL9L in transforming growth factor-β (TGF-β)-induced epithelial-to-mesenchymal-transition (EMT) and metastasis of pancreatic cancer. Oncotarget. 2016;7:73725-73738 pubmed publisher
    ..A growing number of studies indicate that epithelial to mesenchymal transition (EMT), triggered by WNT-, TGF-β- and other signaling pathways is crucial for the initiation of the metastatic process ..
  33. Chen C, Chan C, Chen C, Tsai Y, Tsai T, Wu Lee Y, et al. Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016;25:2905-2922 pubmed
    ..The size of the epiblast marked by Oct3/4 is dramatically reduced in embryonic day 6.5 (E6.5) Ddx3x-/Y embryos...
  34. Liu H, Zhen Q, Fan Y. LncRNA GHET1 promotes esophageal squamous cell carcinoma cells proliferation and invasion via induction of EMT. Int J Biol Markers. 2017;32:e403-e408 pubmed publisher
    ..However, the role of GHET1 in esophageal squamous cell carcinoma (ESCC) remains unclear...
  35. Strowitzki M, Ritter A, Radhakrishnan P, Harnoss J, Opitz V, Biller M, et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep. 2017;7:13151 pubmed publisher
    ..impaired recruitment and activation of peritoneal fibroblasts, mitigated epithelial-mesenchymal-transition (EMT), as well as enhanced fibrinolysis and impaired angiogenesis...
  36. Hooker S, Hernandez W, Chen H, Robbins C, Torres J, Ahaghotu C, et al. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. Prostate. 2010;70:270-5 pubmed publisher
    ..This finding further supports the need to perform GWAS and additional fine mapping in AAs to locate additional susceptibility loci. ..
  37. Mayer S, Hirschfeld M, Jaeger M, Pies S, Iborra S, Erbes T, et al. RON alternative splicing regulation in primary ovarian cancer. Oncol Rep. 2015;34:423-30 pubmed publisher
    ..processes, such as cell motility, adhesion, proliferation, apoptosis and epithelial-to-mesenchymal transition (EMT)...
  38. Ingthorsson S, Briem E, Bergthorsson J, Gudjonsson T. Epithelial Plasticity During Human Breast Morphogenesis and Cancer Progression. J Mammary Gland Biol Neoplasia. 2016;21:139-148 pubmed
    ..e. epithelial plasticity and epithelial to mesenchymal transition (EMT), we will also discuss aspects relevant to cancer progression...
  39. Ping H, Guo L, Xi J, Wang D. Angiotensin II type 2 receptor-interacting protein 3a inhibits ovarian carcinoma metastasis via the extracellular HMGA2-mediated ERK/EMT pathway. Tumour Biol. 2017;39:1010428317713389 pubmed publisher
  40. Huang W, Zhang C, Cui M, Niu J, Ding W. Inhibition of Bevacizumab-induced Epithelial-Mesenchymal Transition by BATF2 Overexpression Involves the Suppression of Wnt/?-Catenin Signaling in Glioblastoma Cells. Anticancer Res. 2017;37:4285-4294 pubmed
    ..However, it also induces epithelial-mesenchymal transition (EMT) in glioblastoma cells, which compromises its efficacy...
  41. Moro M, Bertolini G, Caserini R, Borzi C, Boeri M, Fabbri A, et al. Establishment of patient derived xenografts as functional testing of lung cancer aggressiveness. Sci Rep. 2017;7:6689 pubmed publisher
    ..mirrored parental tumour characteristics although a selective pressure for solid patterns, vimentin expression and EMT was observed in several models...
  42. Wang H, Tao T, Yan W, Feng Y, Wang Y, Cai J, et al. Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma. Sci Rep. 2015;5:13072 pubmed publisher
    ..0031). We also confirmed that NF-κB-targeting genes and the EMT (epithelial-mesenchymal transition) pathway were inversely correlated with miR-181 family expression and that the ..
  43. Chen H, Li H, Chen Q. INPP4B reverses docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer. Biochem Biophys Res Commun. 2016;477:467-72 pubmed publisher
    ..We also found that IGF-1, the inhibitor of PI3K/Akt, markedly blocked the change in EMT markers induced by overexpression of INPP4B, and reversed the resistance of PC3-DR and DU-145-DR cells to docetaxel,..
  44. He Y, Song X, Zhao Z, Zhao H. HOXA13 upregulation in gastric cancer is associated with enhanced cancer cell invasion and epithelial-to-mesenchymal transition. Eur Rev Med Pharmacol Sci. 2017;21:258-265 pubmed
    ..We also explored the functional role of HOXA13 in invasion and epithelial-to-mesenchymal transition (EMT) of gastric cancer cells and the possible signaling pathway it might involve in...
  45. Wang T, Wang M, Fang S, Wang Q, Fang R, Chen J. Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/?-catenin signaling pathway. Oncotarget. 2017;8:18991-19012 pubmed publisher
    ..the role of fibulin-4 in the Wnt/?-catenin pathway and the relationship with epithelial to mesenchymal transition (EMT)...
  46. Kenda Suster N, Smrkolj S, Virant Klun I. Putative stem cells and epithelial-mesenchymal transition revealed in sections of ovarian tumor in patients with serous ovarian carcinoma using immunohistochemistry for vimentin and pluripotency-related markers. J Ovarian Res. 2017;10:11 pubmed publisher
    ..that ovarian carcinogenesis and progression of disease is associated with epithelial-mesenchymal transition (EMT)...
  47. Li Y, Zhang X, Wang X, Wang G, Chuai M, Munsterberg A, et al. Robo signaling regulates the production of cranial neural crest cells. Exp Cell Res. 2017;361:73-84 pubmed publisher
    ..In addition, we found that the transcription factor slug is responsible for the aberrant delamination/EMT of cranial neural crest cells induced by Robo1 KD, which also led to elevated expression of E- and N-Cadherin...
  48. Geng C, Zhang C, Zhang J, Gao P, He M, Li Y. Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma. J Cell Biochem. 2017;: pubmed publisher
    ..develop, special its deacetylase activity plays a key function, but whether SIRT6 plays a role in mediating tumor EMT and metastasis in colon cancer has not been explored...
  49. Sitole B, Mavri Damelin D. Peroxidasin is regulated by the epithelial-mesenchymal transition master transcription factor Snai1. Gene. 2018;646:195-202 pubmed publisher
    ..PXDN is also involved in processes where epithelial-mesenchymal transition (EMT) takes place, namely fibrosis, development and cancer...
  50. Ji C, Wang Y, Xiang D, Liu Q, Zhou Z, Qian F, et al. Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling. Cancer Res. 2018;78:3041-3053 pubmed publisher
    ..1 markedly reduced the invasive and metastatic capabilities as well as the epithelial-mesenchymal transition (EMT) of gastric cancer cells. The promalignant nature of Kir2...
  51. Daman Z, Montazeri H, Azizi M, Rezaie F, Ostad S, Amini M, et al. Polymeric Micelles of PEG-PLA Copolymer as a Carrier for Salinomycin Against Gemcitabine-Resistant Pancreatic Cancer. Pharm Res. 2015;32:3756-67 pubmed publisher
    ..Alterations in CSC phenotype, invasion strength, and mRNA expression of epithelial mesenchymal transition (EMT) markers were also determined in the treated cells...
  52. Cantelli G, Orgaz J, Rodriguez Hernandez I, Karagiannis P, Maiques O, Matias Guiu X, et al. TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination. Curr Biol. 2015;25:2899-914 pubmed publisher
    ..Transforming growth factor β (TGF-β) is well known to promote epithelial-to-mesenchymal transition (EMT) and contribute to metastasis, but melanocytes are neural crest derivatives that have undergone EMT during ..
  53. Ghuwalewala S, Ghatak D, Das P, Dey S, Sarkar S, Alam N, et al. CD44(high)CD24(low) molecular signature determines the Cancer Stem Cell and EMT phenotype in Oral Squamous Cell Carcinoma. Stem Cell Res. 2016;16:405-17 pubmed publisher
    ..cancer cell lines, not only express stem cell related genes but also exhibit Epithelial-to-Mesenchymal transition (EMT) characteristics. This CD44(high)CD24(low) population gives rise to all other cell types upon differentiation...
  54. Li C, Cai M, Jiang L, Mai S, Chen J, Wang F, et al. CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma. Carcinogenesis. 2016;37:557-566 pubmed publisher
    ..EZH2-silenced HCC cells motility and invasive capacities and supported cell epithelial-mesenchymal transition (EMT)...
  55. Hamilton D, Griner L, Keller J, Hu X, Southall N, Marugan J, et al. Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer. Clin Cancer Res. 2016;22:6204-6216 pubmed
    ..an epithelial to a mesenchymal-like phenotype, via a process designated as the epithelial-mesenchymal transition (EMT), is known to mediate tumor resistance to a variety of cell death inducers, including cytotoxic effector immune ..
  56. Kee J, Han Y, Kim D, Mun J, Park J, Jeong M, et al. Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability. Phytomedicine. 2016;23:1680-1690 pubmed publisher
    ..mitogen-activated protein kinases (MAPKs) activation, migration, invasion, epithelial-mesenchymal transition (EMT) and lung metastasis were investigated...
  57. Lu L, Wang J, Wu Y, Wan P, Yang G. Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling. Cancer Med. 2016;5:3544-3554 pubmed publisher
    ..kinase (MAPK) and Notch pathways, leading to the enhanced expression of several epithelial-mesenchymal transition (EMT) markers such as slug, zeb1, vimentin, fibronectin, and MMP9...
  58. Shao L, Li H, Chen J, Song H, Zhang Y, Wu F, et al. Irisin suppresses the migration, proliferation, and invasion of lung cancer cells via inhibition of epithelial-to-mesenchymal transition. Biochem Biophys Res Commun. 2017;485:598-605 pubmed publisher
    ..The expression levels of epithelial-to-mesenchymal transition (EMT) markers and the related signaling pathways were detected by western blot analysis...
  59. Tamaoki M, Komatsuzaki R, Komatsu M, Minashi K, Aoyagi K, Nishimura T, et al. Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications. Cancer Sci. 2018;109:1121-1134 pubmed publisher
    ..Together, SIM2 increases CRT sensitivity through tumor differentiation by cooperation with ARNT. ..
  60. Moheimani F, Roth H, Cross J, Reid A, Shaheen F, Warner S, et al. Disruption of β-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair. Int J Biochem Cell Biol. 2015;68:59-69 pubmed publisher
    ..proliferation, compromised wound healing and an enhanced capacity to undergo epithelial-mesenchymal transition (EMT)...
  61. Su Y, Pogash T, Nguyen T, Russo J. Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities. Cancer Med. 2016;5:558-73 pubmed publisher
    ..The bsMCF, XtMCF, and LmMCF cells have undergone epithelial-mesenchymal transition (EMT), exhibiting a mesenchymal-like feature...
  62. Abouhashem N, Ibrahim D, Mohamed A. Prognostic implications of epithelial to mesenchymal transition related proteins (E-cadherin, Snail) and hypoxia inducible factor 1? in endometrioid endometrial carcinoma. Ann Diagn Pathol. 2016;22:1-11 pubmed publisher
    The epithelial-mesenchymal transition (EMT) is an important step in the invasion and metastasis of cancer...
  63. Prasad C, Chaurasiya S, Guilmain W, Andersson T. WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition. J Exp Clin Cancer Res. 2016;35:144 pubmed publisher
    ..epithelial cell migration/invasion has often but not always been linked to the epithelial-mesenchymal transition (EMT)...
  64. Qin C, Ma D, Ren Z, Zhu X, Wang C, Wang Y, et al. Astragaloside IV inhibits metastasis in hepatoma cells through the suppression of epithelial-mesenchymal transition via the Akt/GSK-3?/?-catenin pathway. Oncol Rep. 2017;37:1725-1735 pubmed publisher
    ..the growth and invasion of hepatocellular carcinoma (HCC) cells, and altered epithelial?mesenchymal transition (EMT) markers in oxaliplatin?treated HCC tissues and cell lines...
  65. Sirohi D, Smith S, Ohe C, Colombo P, Divatia M, Dragoescu E, et al. Renal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinoma. Hum Pathol. 2017;67:134-145 pubmed publisher
    ..All tumors showed PAX8 nuclear positivity and SMARCB1 loss, with OCT3/4 expression in 4 of 5 cases...
  66. Kong X, Liu F, Gao J. MiR-155 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells through the activation of PI3K/SGK3/β-catenin signaling pathways. Oncotarget. 2016;7:66051-66060 pubmed publisher
    ..In this report, we found that SGK3 promotes epithelial-mesenchymal transition (EMT) and reduces phosphorylation-dependent degradation of β-catenin in HCC cells...
  67. Shih Y, Radeke M, Radeke C, Coffey P. Restoration of Mesenchymal RPE by Transcription Factor-Mediated Reprogramming. Invest Ophthalmol Vis Sci. 2017;58:430-441 pubmed publisher
    Transforming growth factor ?-mediated epithelial-to-mesenchymal transition (EMT) is a major component of the wound healing response and a negative determinant of retinal pigment epithelium (RPE) differentiation...
  68. Dong X, Jia Y, Ge L, Jiang B, Jiang J, Shen J, et al. Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Toxicology. 2017;389:31-41 pubmed publisher
    ..growth factor (TGF)-?1-induced epithelial proliferation and epithelial-mesenchymal transition (EMT) in vitro by monitoring changes in pulmonary function, inflammatory response, fibrotic remodeling, and signaling ..
  69. Chen Q, Yang D, Zong H, Zhu L, Wang L, Wang X, et al. Growth-induced stress enhances epithelial-mesenchymal transition induced by IL-6 in clear cell renal cell carcinoma via the Akt/GSK-3?/?-catenin signaling pathway. Oncogenesis. 2017;6:e375 pubmed publisher
    ..critical diver that induces ?-SMA (+) cells in ccRCC tissues via promotion of epithelial to mesenchymal transition (EMT) and stimulates migration and invasion in ccRCC...
  70. Gaianigo N, Melisi D, Carbone C. EMT and Treatment Resistance in Pancreatic Cancer. Cancers (Basel). 2017;9: pubmed publisher
    ..in PC and is mainly attributed to an evolutionary biological process called epithelial-to-mesenchymal transition (EMT)...
  71. Busch E, Don P, Chu H, Richardson D, Keku T, Eberhard D, et al. Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors. BMC Cancer. 2018;18:82 pubmed publisher
    Metastases play a role in about 90% of cancer deaths. Markers of epithelial-mesenchymal transition (EMT) measured in primary tumor cancer cells might provide diagnostic information about the likelihood that cancer cells have detached ..
  72. Wan X, Cheng C, Shao Q, Lin Z, Lu S, Chen Y. CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment. Tumour Biol. 2016;37:6073-84 pubmed publisher
    ..Further, the epithelial-mesenchymal transition (EMT) and Notch1 signaling activations mediated by CD24 were elucidated as potential mechanisms of HCC promotion in ..
  73. Jiang S, He X, Xia Y, Hu W, Luo J, Zhang J, et al. MicroRNA-145-5p inhibits gastric cancer invasiveness through targeting N-cadherin and ZEB2 to suppress epithelial-mesenchymal transition. Onco Targets Ther. 2016;9:2305-15 pubmed publisher
    ..Epithelial-mesenchymal transition (EMT) is an important process in cancer invasion and migration...
  74. Basilicata M, Frank M, Solter D, Brabletz T, Stemmler M. Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation. Sci Rep. 2016;6:26562 pubmed publisher
    ..switching from E-cadherin (E-cad) to N-cadherin (N-cad) is a key step of the epithelial-mesenchymal transition (EMT) processes that occurs during gastrulation and cancer progression...
  75. Dinglin X, Ding L, Li Q, Liu Y, Zhang J, Yao H. RYBP Inhibits Progression and Metastasis of Lung Cancer by Suppressing EGFR Signaling and Epithelial-Mesenchymal Transition. Transl Oncol. 2017;10:280-287 pubmed publisher
    ..nude mice, and the expressions of genes in EGFR-related signaling pathways and epithelial-mesenchymal transition (EMT) were detected...
  76. Shao J, Gao Z, Huang W, Lu Z. The mechanism of epithelial-mesenchymal transition induced by TGF-?1 in neuroblastoma cells. Int J Oncol. 2017;50:1623-1633 pubmed publisher
    ..The epithelial-mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis...
  77. Tam K, Hui D, Lee W, Dong M, Tombe T, Jiao I, et al. Semaphorin 3 C drives epithelial-to-mesenchymal transition, invasiveness, and stem-like characteristics in prostate cells. Sci Rep. 2017;7:11501 pubmed publisher
    ..and its augmented expression in PCa, we hypothesized that SEMA3C promotes epithelial-to-mesenchymal transition (EMT) and stem-like phenotypes in prostate cells...
  78. Bai Z, Wang J, Wang T, Li Y, Zhao X, Wu G, et al. The MiR-495/Annexin A3/P53 Axis Inhibits the Invasion and EMT of Colorectal Cancer Cells. Cell Physiol Biochem. 2017;44:1882-1895 pubmed publisher
    ..A miR-495 mimic and inhibitor were transfected into CRC cells, and the effects of miR-495 on the invasion and EMT were explored by qRT-PCR as well as transwell and Western blot assays...
  79. Cai S, Zhang P, Dong S, Li L, Cai J, Xu M. Downregulation of SPINK13 Promotes Metastasis by Regulating uPA in Ovarian Cancer Cells. Cell Physiol Biochem. 2018;45:1061-1071 pubmed publisher
    ..Moreover, SPINK13 inhibited cell migration and epithelial to mesenchymal transition (EMT)...
  80. Efazat G, Novak M, Kaminskyy V, De Petris L, Kanter L, Juntti T, et al. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer. Oncotarget. 2016;7:60332-60347 pubmed publisher
    ..We also found the EMT marker E-cadherin expression to be maintained or increased upon Ephrin B3 blockade in NSCLC cells...
  81. Schiffmacher A, Xie V, Taneyhill L. Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation. J Cell Biol. 2016;215:735-747 pubmed
    ..crest cells reduce Cadherin-6B (Cad6B) levels through several mechanisms, including proteolysis, to permit their EMT and migration...
  82. Lam M, Roszik J, Kanikarla Marie P, Davis J, Morris J, Kopetz S, et al. The potential role of platelets in the consensus molecular subtypes of colorectal cancer. Cancer Metastasis Rev. 2017;36:273-288 pubmed publisher
    ..features including complement activation, matrix remodeling, angiogenesis, epithelial-mesechymal transition (EMT), integrin upregulation and stromal infiltration...
  83. Liu L, Xiao W. Notch1 signaling induces epithelial-mesenchymal transition in lens epithelium cells during hypoxia. BMC Ophthalmol. 2017;17:135 pubmed publisher
    ..Epithelial-Mesenchymal Transition (EMT) of lens epithelium cells (LEC) is the pathological basis of PCO...
  84. Xiao X, Fischbach S, Zhang T, Chen C, Sheng Q, Zimmerman R, et al. SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes. Diabetes. 2017;66:2646-2658 pubmed publisher
    ..Loss of β-cell mass was then found to result from TGFβ1-triggered epithelial-mesenchymal transition (EMT) by β-cells, rather than resulting directly from β-cell apoptosis...
  85. Nishio K, Kimura K, Amano R, Nakata B, Yamazoe S, Ohira G, et al. Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma. World J Gastroenterol. 2017;23:5764-5772 pubmed publisher
    ..for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition (EMT) marker expression, and cancer stem cell (CSC) marker expression...
  86. Wu Y, Tang L. Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals. Curr Pharm Des. 2016;22:4700-4704 pubmed
    ..signal plays a major role in many cellular processes, such as apoptosis and epithelial to mesenchymal transition (EMT). The role of Ca2+ in apoptotic signaling has been investigated deeply over the past few decades...
  87. Raghavan C, Nagaraj R. AGE-RAGE interaction in the TGF?2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016;33:631-43 pubmed publisher
    ..reported that AGEs in the human lens capsule (BM) promote the TGF?2-mediated epithelial-to-mesenchymal transition (EMT) of lens epithelial cells, which we proposed as a mechanism for posterior capsule opacification (PCO) or secondary ..
  88. Zhang S, Hong Z, Chai Y, Liu Z, Du Y, Li Q, et al. CSN5 promotes renal cell carcinoma metastasis and EMT by inhibiting ZEB1 degradation. Biochem Biophys Res Commun. 2017;488:101-108 pubmed publisher
    ..Additionally, CSN5 contributes to the metastasis and EMT (epithelial-mesenchymal transition) of RCC cells...
  89. Kurdin A, Caines A, Boone D, Furey A. TEAM: A Low-Cost Alternative to ATLS for Providing Trauma Care Teaching in Haiti. J Surg Educ. 2018;75:377-382 pubmed publisher
    ..Response was obtained from 69 participants, which comprised of 32 physicians, 10 Emergency Medical Technicians (EMT), 22 nurses, and 5 medical trainees...
  90. Maruyama J, Inami K, Michishita F, Jiang X, Iwasa H, Nakagawa K, et al. Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth. Mol Cancer Res. 2018;16:197-211 pubmed publisher
    ..and YAP1 gene amplification lead to the activation of YAP1, which induces epithelial-mesenchymal transition (EMT) and drug resistance. YAP1 inhibitors are expected to be useful in cancer therapy...
  91. Wang J, Tian L, Khan M, Zhang L, Chen Q, Zhao Y, et al. Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness. Cancer Lett. 2018;415:73-85 pubmed publisher
    ..Hypoxia caused alterations in epithelial-mesenchymal transition (EMT), which were detected by cellular morphology and EMT protein markers, and in stemness analyzed by spheroid ..
  92. Yu J, Li J, Chen Y, Cao W, Lu Y, Yang J, et al. Snail Enhances Glycolysis in the Epithelial-Mesenchymal Transition Process by Targeting FBP1 in Gastric Cancer. Cell Physiol Biochem. 2017;43:31-38 pubmed publisher
    Snail is a key regulator of epithelial-mesenchymal transition (EMT) in cancer. However, the regulatory role and underlying mechanisms of Snail in gastric cancer metabolism are unknown...