Gene Symbol: SLC22A23
Description: solute carrier family 22 member 23
Alias: C6orf85, solute carrier family 22 member 23, ion transporter protein
Species: human
Products:     SLC22A23

Top Publications

  1. Jacobsson J, Haitina T, Lindblom J, Fredriksson R. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics. 2007;90:595-609 pubmed
    ..Five of these belong to the SLC22 family, SLC22A20, SLC22A23, SLC22A24, SLC22A25, and SPNS3, and the sixth gene, SVOPL, is a paralog to the synaptic vesicle protein SVOP...
  2. Ekizoglu S, Seven D, Ulutin T, Guliyev J, Buyru N. Investigation of the SLC22A23 gene in laryngeal squamous cell carcinoma. BMC Cancer. 2018;18:477 pubmed publisher
    ..One of the differentially expressed genes was the SLC22A23 (solute carrier family 22, member 23) gene...
  3. Duga B, Czakó M, Komlósi K, Hadzsiev K, Sümegi K, Kisfali P, et al. [Attention deficit hyperactivity disorder analyzed with array comparative genome hybridization method. Case report]. Orv Hetil. 2014;155:1598-601 pubmed publisher
    ..Both duplications affect genes (6p25.2: SLC22A23; 15q13.3: CHRNA7) which may play a role in the development of attention deficit hyperactivity disorder...
  4. Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, et al. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015;21:820-6 pubmed publisher
    ..that IL18 interacts with the Na-Cl co-transporter (NCC; also known as SLC12A3), a 12-transmembrane-domain ion transporter protein preferentially expressed in the kidney...
  5. Singh N, Raghav M, Narula S, Tandon S, Goel G. Profiling of Virulence Determinants in Cronobacter sakazakii Isolates from Different Plant and Environmental Commodities. Curr Microbiol. 2017;74:560-565 pubmed publisher
    ..genes were detected at a level of 60% for both cpa (cronobacter plasminogen activator) and eitA (Ferric ion transporter protein) gene, respectively. Furthermore, the isolate C. sakazakii N81 showed cytotoxicity for Caco-2 cells...
  6. Reyer H, Shirali M, Ponsuksili S, Murani E, Varley P, Jensen J, et al. Exploring the genetics of feed efficiency and feeding behaviour traits in a pig line highly selected for performance characteristics. Mol Genet Genomics. 2017;292:1001-1011 pubmed publisher
    ..The positional and functional candidate genes identified are involved in transport processes like AQP4, SLC22A23, and SLC6A14 as well as energy sensing, generation, and utilization as exemplified by PPP3CA, IQGAP3, ECI2, and ..
  7. Shen Y, Nicoletti P, Floratos A, Pirmohamed M, Molokhia M, Geppetti P, et al. Genome-wide association study of serious blistering skin rash caused by drugs. Pharmacogenomics J. 2012;12:96-104 pubmed publisher
    ..Our GWAS did not find common, highly penetrant genetic risk factors responsible for SJS/TEN events in the cases selected. ..
  8. Oz T, Guvenek A, Yildiz S, Karaboga E, Tamer Y, Mumcuyan N, et al. Strength of selection pressure is an important parameter contributing to the complexity of antibiotic resistance evolution. Mol Biol Evol. 2014;31:2387-401 pubmed publisher
    ..other drug classes compared with their wild-type ancestor as a result of a point mutation on TrkH, an ion transporter protein. Our findings suggest that selection strength is an important parameter contributing to the complexity of ..
  9. Cleynen I, Mahachie John J, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K, et al. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. PLoS ONE. 2010;5:e12952 pubmed publisher
    ..The used technique can be applied to other common complex diseases as well, and will help to complete patient characterization, in order to evolve towards personalized medicine. ..

More Information


  1. Aberg K, Adkins D, Liu Y, McClay J, Bukszár J, Jia P, et al. Genome-wide association study of antipsychotic-induced QTc interval prolongation. Pharmacogenomics J. 2012;12:165-72 pubmed publisher
    ..10 (P-value=1.54 × 10(-7), Q-value=0.07), located in SLC22A23, mediated the effects of quetiapine on prolongation...
  2. Anderson C, Massey D, Barrett J, Prescott N, Tremelling M, Fisher S, et al. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology. 2009;136:523-9.e3 pubmed publisher
    ..ECM1 variation was not associated with CD. Collectively, these data help define the genetic relationship between CD and UC and characterize common, as well as disease-specific mechanisms of pathogenesis. ..
  3. Weersma R, Stokkers P, Cleynen I, Wolfkamp S, Henckaerts L, Schreiber S, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009;104:630-8 pubmed publisher
    ..We show that a genetic risk profile can be constructed that is clinically useful and that can aid in making treatment decisions. ..
  4. Serrano León A, Amir Shaghaghi M, Yurkova N, Bernstein C, El Gabalawy H, Eck P. Single-nucleotide polymorphisms in SLC22A23 are associated with ulcerative colitis in a Canadian white cohort. Am J Clin Nutr. 2014;100:289-94 pubmed publisher
    b>SLC22A23 is an orphan gene in the SLC22 family of organic membrane transporters, and its single-nucleotide polymorphism rs17309827-T was recently nominally associated with intestinal inflammation in a genome-wide association study...