SLC1A5

Summary

Gene Symbol: SLC1A5
Description: solute carrier family 1 member 5
Alias: AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC, neutral amino acid transporter B(0), ATB(0), RD114 virus receptor, RD114/simian type D retrovirus receptor, baboon M7 virus receptor, neutral amino acid transporter B, sodium-dependent neutral amino acid transporter type 2, solute carrier family 1 (neutral amino acid transporter), member 5
Species: human
Products:     SLC1A5

Top Publications

  1. Lavillette D, Marin M, Ruggieri A, Mallet F, Cosset F, Kabat D. The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. J Virol. 2002;76:6442-52 pubmed
    ..formation by interacting with the human sodium-dependent neutral amino acid transporter type 2 (hASCT2; gene name, SLC1A5) (J.-L. Blond, D. Lavillette, V. Cheynet, O. Bouton, G. Oriol, S. Chapel-Fernandez, B. Mandrand, F. Mallet, and F...
  2. Tailor C, Nouri A, Zhao Y, Takeuchi Y, Kabat D. A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses. J Virol. 1999;73:4470-4 pubmed
    ..The human Bo transporter gene has been previously mapped to 19q13.3, which is closely linked to the gene locus of the RD114 receptor...
  3. Rasko J, Battini J, Gottschalk R, Mazo I, Miller A. The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. Proc Natl Acad Sci U S A. 1999;96:2129-34 pubmed
    ..The cloned cDNA, denoted RDR, is an allele of the previously cloned neutral amino acid transporter ATB0 (SLC1A5). Both RDR and ATB0 serve as retrovirus receptors and both show specific transport of neutral amino acids...
  4. Cheynet V, Oriol G, Mallet F. Identification of the hASCT2-binding domain of the Env ERVWE1/syncytin-1 fusogenic glycoprotein. Retrovirology. 2006;3:41 pubmed
  5. Salama A, Duque M, Wang L, Shahzad K, Olivera M, Loor J. Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat-stressed bovine mammary epithelial cells in vitro. J Dairy Sci. 2019;102:2469-2480 pubmed publisher
    ..transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67)...
  6. Lin M, Zhang B, Yu C, Li J, Zhang L, Sun H, et al. L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. PLoS ONE. 2014;9:e111950 pubmed publisher
    ..CaR), metabotropic glutamate receptor 1 (mGluR1) and metabotropic glutamate receptor 4 (mGluR4), and neutral amino acid transporter B(0)-like (SLC1A5) in the jejunal mucosa...
  7. Holm L, Krogvold L, Hasselby J, Kaur S, Claessens L, Russell M, et al. Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia. 2018;61:1650-1661 pubmed publisher
    ..Next, we discovered eight gene polymorphisms (ORMDL3, SPHK2, B4GALNT1, SLC1A5, GALC, PPARD, PPARG and B4GALT1) involved in sphingolipid metabolism that contribute to the genetic predisposition ..
  8. Tavakoli S, Downs K, Short J, Nguyen H, Lai Y, Jerabek P, et al. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2017;37:1840-1848 pubmed publisher
    ..the enhanced glutamine accumulation, which was associated with increased expression of a glutamine transporter, Slc1a5...
  9. Xu X, Li J, Sun X, Guo Y, Chu D, Wei L, et al. Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. Oncotarget. 2015;6:26161-76 pubmed publisher
    ..the catalytic enzymes involved in glutaminolysis revealed that glutamine transporter ASC amino-acid transporter 2 (ASCT2) and glutaminase 1 (GLS1) was also significantly suppressed by NDRG2...

More Information

Publications127 found, 100 shown here

  1. Yang X, Wang G, Gong X, Huang C, Mao Q, Zeng L, et al. Effects of chronic stress on intestinal amino acid pathways. Physiol Behav. 2019;204:199-209 pubmed publisher
    ..blot analysis revealed that CUMS rats exhibited a reduction in the expression levels of amino acid transporters ASCT2 and B0AT1, as well as an increase in LAT1 expression...
  2. Andersson M, Ersson L, Brandt I, Bergstrom U. Potential transfer of neurotoxic amino acid ?-N-methylamino-alanine (BMAA) from mother to infant during breast-feeding: Predictions from human cell lines. Toxicol Appl Pharmacol. 2017;320:40-50 pubmed publisher
    ..In competition experiments with various amino acids, the ASCT2 specific inhibitor benzylserine was the most effective inhibitor of [14C]l-BMAA uptake tested here...
  3. Chen Z, Wang Y, Warden C, Chen S. Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells. J Steroid Biochem Mol Biol. 2015;149:118-27 pubmed publisher
    ..ER down-regulator fulvestrant inhibited MYC, SLC1A5, glutaminase (GLS) and glutamine consumption in AI resistant breast cancer cells...
  4. Frese S, Ruebner M, Suhr F, Konou T, Tappe K, Toigo M, et al. Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo. PLoS ONE. 2015;10:e0132099 pubmed publisher
    ..Cellular receptors SLC1A4 and SLC1A5 of Syncytin-1 showed significant decrease of expression in post-competitive muscles compared with the pre-..
  5. Zhang G, Ducatelle R, De Bruyne E, Joosten M, Bosschem I, Smet A, et al. Role of γ-glutamyltranspeptidase in the pathogenesis of Helicobacter suis and Helicobacter pylori infections. Vet Res. 2015;46:31 pubmed publisher
    ..suis. Interestingly, H. suis GGT was shown to affect the glutamine metabolism of gastric epithelium through downregulation of the glutamine transporter ASCT2.
  6. Pidoux G, Gerbaud P, Guibourdenche J, Thérond P, Ferreira F, Simasotchi C, et al. Formaldehyde Crosses the Human Placenta and Affects Human Trophoblast Differentiation and Hormonal Functions. PLoS ONE. 2015;10:e0133506 pubmed publisher
    ..human trophoblast fusion by upregulating syncitin-1 receptor expression (ASC-type amino-acid transporter 2: ASCT2)...
  7. Liu P, Ge M, Hu J, Li X, Che L, Sun K, et al. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis. Hepatology. 2017;66:167-181 pubmed publisher
    ..analysis revealed up-regulation of multiple amino acid transporters, including solute carrier family 1 member A5 (SLC1A5) and SLC7A6, leading to robust uptake of amino acids, including glutamine, into c-Myc tumor cells...
  8. Pathria G, Scott D, Feng Y, Sang Lee J, Fujita Y, Zhang G, et al. Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival. EMBO J. 2018;37: pubmed publisher
    ..This includes the upregulation of glutamine transporter SLC1A5 and glutamine uptake, with concomitant build-up of essential amino acids, and mTORC1 activation, to ameliorate the ..
  9. Lam H, Baglini C, Lope A, Parkhitko A, Liu H, Alesi N, et al. p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer Res. 2017;77:3255-3267 pubmed publisher
    ..p62 positively regulated the glutamine transporter Slc1a5 and increased glutamine uptake in Tsc2-null cells...
  10. Wang Y, Liu J, Wu H, Fang X, Chen H, Zhang C. Amino acids regulate mTOR pathway and milk protein synthesis in a mouse mammary epithelial cell line is partly mediated by T1R1/T1R3. Eur J Nutr. 2017;56:2467-2474 pubmed publisher
    ..T1R1 knockdown increased the mRNAs coding three important amino acid transporters (SLC1A5 and SLC3A2/SLC7A5)...
  11. Venmar K, Kimmel D, Cliffel D, Fingleton B. IL4 receptor α mediates enhanced glucose and glutamine metabolism to support breast cancer growth. Biochim Biophys Acta. 2015;1853:1219-28 pubmed publisher
    ..metabolism in MDA-MB-231 human breast cancer cells, it increased expression of the main glutamine transporter, ASCT2, and enhanced glutamine consumption in both MDA-MB-231 and 4T1 cells...
  12. Huang W, Chang J, Wang P, Liu C, Yin Q, Song A, et al. Effect of Compound Probiotics and Mycotoxin Degradation Enzymes on Alleviating Cytotoxicity of Swine Jejunal Epithelial Cells Induced by Aflatoxin B₁ and Zearalenone. Toxins (Basel). 2019;11: pubmed publisher
    ..and ZO-1 genes were significantly upregulated, while Bax, caspase-3, GLUT2, ASCT2, PepT1, and IL6 genes were significantly downregulated by CFSCP + MDE addition, compared to the ..
  13. Díaz Carballo D, Klein J, Acikelli A, Wilk C, Saka S, Jastrow H, et al. Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells. Oncotarget. 2017;8:95945-95964 pubmed publisher
    ..In addition, mitochondrial preparations also contained the corresponding receptors, i.e. ASCT2 and MFSD2...
  14. Labenski V, Suerth J, Barczak E, Heckl D, Levy C, Bernadin O, et al. Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Biomaterials. 2016;97:97-109 pubmed publisher
    ..we established a stable, human alpharetroviral packaging cell line in which we deleted the entry receptor (SLC1A5) for RD114/TR-pseudotyped ARVs to prevent superinfection and enhance genomic integrity of the packaging cell line ..
  15. Walaszczyk E, Luijten M, Spijkerman A, Bonder M, Lutgers H, Snieder H, et al. DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1c levels: a systematic review and replication in a case-control sample of the Lifelines study. Diabetologia. 2018;61:354-368 pubmed publisher
    ..05). The results for five CpGs (in ABCG1, LOXL2, TXNIP, SLC1A5 and SREBF1) remained significant after a stringent multiple-testing correction (changes in methylation from -3% up ..
  16. Richard M, Huan T, Ligthart S, Gondalia R, Jhun M, Brody J, et al. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. Am J Hum Genet. 2017;101:888-902 pubmed publisher
    ..influences BP, while BP influences methylation at cg00533891 (ZMIZ1), cg00574958 (CPT1A), and cg02711608 (SLC1A5)...
  17. Xia W, Osorio J, Yang Y, Liu D, Jiang M. Short communication: Characterization of gene expression profiles related to yak milk protein synthesis during the lactation cycle. J Dairy Sci. 2018;101:11150-11158 pubmed publisher
    ..Specifically, there was an increased expression of mTOR-related amino acid transporters (SLC1A5, SLC7A5, and SLC36A1), glucose transporters (SLC2A1, SLC2A3, and SLC2A8), Jak2-Stat5 pathway (ELF5), and insulin ..
  18. Alenina N, Bader M. ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models. Neurochem Res. 2018;: pubmed publisher
    ..to ACE and the C-terminus is homologous to collectrin and responsible for the trafficking of the neutral amino acid transporter B(0)AT1 to the plasma membrane of gut epithelial cells...
  19. Shen L, Chen Y, Yang A, Chen C, Liao L, Li S, et al. Redox Proteomic Profiling of Specifically Carbonylated Proteins in the Serum of Triple Transgenic Alzheimer's Disease Mice. Int J Mol Sci. 2016;17:469 pubmed publisher
    ..IGH-3), Ig lambda-2 chain C region (IGLC2), Ig kappa chain C region (IGKC), and Ig kappa chain V-V region HP R16.7 were identified as significantly oxidized proteins compared with the control...
  20. Xu Y, Hu Z, Wang C, Zhang X, Li J, Yue B. Characterization of perfect microsatellite based on genome-wide and chromosome level in Rhesus monkey (Macaca mulatta). Gene. 2016;592:269-75 pubmed publisher
    ..The predominant repeat types in male Rhesus monkey genome and chromosome Y were basically A, AC, AG, AAT, AAC, AAAT, AAAC, AAAG, AAACA and AAACAA...
  21. Liu J, Wang Y, Li D, Wang Y, Li M, Chen C, et al. Milk protein synthesis is regulated by T1R1/T1R3, a G protein-coupled taste receptor, through the mTOR pathway in the mouse mammary gland. Mol Nutr Food Res. 2017;61: pubmed publisher
    ..also increased the protein abundance of the AA transporter SLC3A2 and mRNA expression of SLC7A5/SLC3A2 and SLC1A5. Activation of the mTOR pathway was repressed by inhibition of T1R3 or T1R1 knockout in mammary gland explants...
  22. Sontakke P, Koczula K, Jaques J, Wierenga A, Brouwers Vos A, Pruis M, et al. Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation. PLoS ONE. 2016;11:e0153226 pubmed publisher
    ..Expression of the glutamine importer SLC1A5 was increased in BCR-ABL+ cells, coinciding with an increased susceptibility to the glutaminase inhibitor BPTES...
  23. Gruenwald K, Holland J, Stromberg V, Ahmad A, Watcharakichkorn D, Okumoto S. Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors. PLoS ONE. 2012;7:e38591 pubmed publisher
    ..Using cos7 cells expressing the human glutamine transporter ASCT2 as a model, we demonstrate that the properties of the glutamine transporter can easily be analyzed with these ..
  24. Vastrad C, Vastrad B. Bioinformatics analysis of gene expression profiles to diagnose crucial and novel genes in glioblastoma multiform. Pathol Res Pract. 2018;214:1395-1461 pubmed publisher
    ..genes regulatory network with higher degrees as hub genes, which included MYC, TERF2IP, CDK1, EEF1G, TXNIP, SLC1A5, RGS4 and IER5L Survival suggested that low expressed NR4A2, SLC7 A5, CYR61 and ID1 in patients with GBM was ..
  25. Li S, Loor J, Liu H, Liu L, Hosseini A, Zhao W, et al. Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants. J Dairy Sci. 2017;100:6676-6688 pubmed publisher
    ..In MAC-T cells, the OPAA upregulated the mRNA expression of SLC1A5 and SLC7A5 but downregulated the expression of IRS1, AKT3, EEF1A1, and EEF2 compared with the control...
  26. Wasala N, Shin J, Lai Y, Yue Y, Montanaro F, Duan D. Cardiac specific expression of ∆H2-R15 mini-dystrophin normalized all ECG abnormalities and the end-diastolic volume in a 23-m-old mouse model of Duchenne dilated cardiomyopathy. Hum Gene Ther. 2018;: pubmed publisher
    ..to the ∆H2-R19 minigene, the ∆H2-R15 minigene carries dystrophin spectrin-like repeats 16 to 19 (R16-19), a region that has been suggested to protect the heart in clinical studies...
  27. Noh H, Woo J, Lee S, Jang Y. Metabolic engineering of Clostridium acetobutylicum for the production of butyl butyrate. Appl Microbiol Biotechnol. 2018;102:8319-8327 pubmed publisher
    ..8% of total esters produced. Also, the engineered C. acetobutylicum strain CaAAAT expressing the apple AAAT gene produced 40.60 mg/L of butyl butyrate with a selectivity of 87.4%...
  28. Zhuang X, Li J, Brost B, Xia X, Chen H, Wang C, et al. Decreased expression and altered methylation of syncytin-1 gene in human placentas associated with preeclampsia. Curr Pharm Des. 2014;20:1796-802 pubmed
    ..The mRNA levels of ASCT2, the syncytin-1 receptor involved in cell fusion process, and GCMa, a transcriptional factor known to regulate ..
  29. Tripuraneni N, Azam M. Pharmacophore modeling, 3D-QSAR, and docking study of pyrozolo[1,5-a]pyridine/4,4-dimethylpyrazolone analogues as PDE4 selective inhibitors. J Mol Model. 2015;21:289 pubmed publisher
    ..The pharmacophoric features R15 and R16 exhibited π-π stacking with His234, Phe414, and Phe446 residues...
  30. Dimitroula H, Syranidou E, Manousaki E, Nikolaidis N, Karatzas G, Kalogerakis N. Mitigation measures for chromium-VI contaminated groundwater - The role of endophytic bacteria in rhizofiltration. J Hazard Mater. 2015;281:114-20 pubmed publisher
    ..The endophytic bacteria Pseudomonas sp. strain R16 and Ochrobactrum sp. strain R24 were chosen for Cr(VI) reduction assays...
  31. Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, et al. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017;16:81 pubmed publisher
    ..Correlating GWIS results with in vitro transcriptomic profiles identified one common gene, SLC1A5, which is involved in synaptic function, neuronal development, and excitotoxicity...
  32. Yi D, Hou Y, Wang L, Ouyang W, Long M, Zhao D, et al. L-Glutamine enhances enterocyte growth via activation of the mTOR signaling pathway independently of AMPK. Amino Acids. 2015;47:65-78 pubmed publisher
    ..Gln also increased mRNA levels for Bcl-2, mTOR, p70S6 kinase, 4E-BP1, COX7C, ASCT2, ODC, SGLT-1, CFTR, Na(+)/K(+)-ATPase, HSP70, and ZO-1...
  33. Alesaeidi S, Karami J, Mahmoudi M, Akbarian M, Poursani S, Amirzadeh A, et al. Methyl-CpG-Binding Protein 2 (MECP2) Polymorphism in Iranian Patients with Systemic Lupus Erythematosus. Inflammation. 2015;38:2185-90 pubmed publisher
    ..012), and a significant AAAT haplotype frequency was observed in the control group (p = 0.0003)...
  34. Leke R, Schousboe A. The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle. Adv Neurobiol. 2016;13:223-257 pubmed
    ..b>ASCT2 is a Na+-dependent antiporter, the participation of which in the GGC also remains to be better ..
  35. Barton S, Mosquera M, Cleal J, Fuller A, Crozier S, Cooper C, et al. Relation of FTO gene variants to fetal growth trajectories: Findings from the Southampton Women's survey. Placenta. 2016;38:100-6 pubmed publisher
    ..but higher placental FTO expression was independently associated with larger fetal size and higher placental ASCT2, EAAT2 and y + LAT2 amino acid transporter expression...
  36. Jiang S, Yan W, Wang S, Baltimore D. Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients. Cell Metab. 2018;27:393-403.e4 pubmed publisher
    ..glucose and glutamine, through directly targeting hexokinase 2 (Hk2) and by repressing a glutamine transporter Slc1a5 and a key degradation enzyme, glutaminase (Gls), a mechanism mediated by regulation of c-Myc...
  37. Pérez Escuredo J, Dadhich R, Dhup S, Cacace A, Van Hée V, De Saedeleer C, et al. Lactate promotes glutamine uptake and metabolism in oxidative cancer cells. Cell Cycle. 2016;15:72-83 pubmed publisher
    ..Consequently, lactate-induced c-Myc activation triggers the expression of glutamine transporter ASCT2 and of glutaminase 1 (GLS1), resulting in improved glutamine uptake and catabolism...
  38. Ziółkowska Suchanek I, Mosor M, Gabryel P, Grabicki M, Żurawek M, Fichna M, et al. Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases. Sci Rep. 2015;5:13502 pubmed publisher
    ..002, OR < 0.405). Haplotype-based tests identified an association of the IREB2 AAAT haplotype with LC (P = 0.0021, OR = 1...
  39. Hu J, Shi Y, Wang C, Wan H, Wu D, Wang H, et al. Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury. Sci Rep. 2018;8:3201 pubmed publisher
    ..ITF enhanced autophagy, reduces endoplasmic reticulum stress (ERS), and alleviates the impaired PDI, ASCT2, and B0AT1 in IECs and BBMVs after burn injury likely through AMPK activation...
  40. Torborg A, Ryan L, Kantor G, Biccard B. The pharmacoeconomics of routine postoperative troponin surveillance to prevent and treat myocardial infarction after non-cardiac surgery. S Afr Med J. 2014;104:619-23 pubmed publisher
    ..surveillance with initiation of aspirin and statin therapy was cost-effective, with an incremental cost of -R16,724 per event avoided...
  41. Liu Y, Kong X, Li F, Tan B, Li Y, Duan Y, et al. Co-dependence of genotype and dietary protein intake to affect expression on amino acid/peptide transporters in porcine skeletal muscle. Amino Acids. 2016;48:75-90 pubmed publisher
    ..05) the mRNA levels for PAT1, PAT2, and ASCT2, which transport neutral AAs into muscles. Bama mini-pigs had higher (P < 0...
  42. Lodi A, Saha A, Lu X, Wang B, Sentandreu E, Collins M, et al. Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism. NPJ Precis Oncol. 2017;1: pubmed publisher
    ..In addition, ASCT2 levels and STAT3, mTORC1 and AMPK activity were modulated to a greater extent by the combinations compared to the ..
  43. Nagashima H, Lilly Thankamony A, Trebosc J, Pourpoint F, Lafon O, Amoureux J. ?-Independent through-space hetero-nuclear correlation between spin-1/2 and quadrupolar nuclei in solids. Solid State Nucl Magn Reson. 2017;84:216-226 pubmed publisher
    ..These experiments indicate that R1635 recoupling produces the highest signal-to-noise ratio in heteronuclear correlation 2D ..
  44. Deng X, Sagata N, Takeuchi N, Tanaka M, Ninomiya H, Iwata N, et al. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. BMC Psychiatry. 2008;8:58 pubmed publisher
    ..We report here association studies of schizophrenia with SLC1A4, SLC1A5 encoding neutral amino acid transporters ASCT1, ASCT2, and SLC6A5, SLC6A9 encoding glycine transporters GLYT2, ..
  45. Sadeq M, Abouqal R, ElMarnissi A. Secular trends in consultations for asthma in early childhood, the 16 administrative regions of Morocco, 2004-2012. BMC Public Health. 2015;15:905 pubmed publisher
    ..increase in prevalence rates was shown in both urban and rural Morocco, particularly in urban areas of R10, R14, R16 and R5, and in rural areas of R14 and R16...
  46. Cormerais Y, Massard P, Vucetic M, Giuliano S, Tambutte E, Durivault J, et al. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018;293:2877-2887 pubmed publisher
    The transporters for glutamine and essential amino acids, ASCT2 (solute carrier family 1 member 5, SLC1A5) and LAT1 (solute carrier family 7 member 5, SLC7A5), respectively, are overexpressed in aggressive cancers and have been identified ..
  47. Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, et al. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ. 2018;25:1457-1472 pubmed publisher
    ..Here we show that miR-137 negatively regulates ferroptosis by directly targeting glutamine transporter SLC1A5 in melanoma cells...
  48. Johnson S, Cummins I, Lim F, Slabas A, Knight M. Transcriptomic analysis comparing stay-green and senescent Sorghum bicolor lines identifies a role for proline biosynthesis in the stay-green trait. J Exp Bot. 2015;66:7061-73 pubmed publisher
    ..Here, a transcriptomic approach was used to compare gene expression between stay-green (B35) and senescent (R16) sorghum varieties...
  49. Yu M, Mu C, Yang Y, Zhang C, Su Y, Huang Z, et al. Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets. Amino Acids. 2017;49:1587-1599 pubmed publisher
    ..Antibiotics upregulated (P < 0.05) the mRNA expression levels for jejunal AAs transporters (CAT1, EAAC1, ASCT2, y+LAT1), peptide transporters (PepT1), and Na+-K+-ATPase (ATP1A1), and ileal AA ..
  50. Passera A, Venturini G, Battelli G, Casati P, Penaca F, Quaglino F, et al. Competition assays revealed Paenibacillus pasadenensis strain R16 as a novel antifungal agent. Microbiol Res. 2017;198:16-26 pubmed publisher
    ..growth promoting potential and antifungal effect exerted by a novel, putative candidate biocontrol agent, strain R16, identified as Paenibacillus pasadenensis by sequence analysis of 16S rRNA and rpoB genes, against three important ..
  51. Ye J, Huang Q, Xu J, Huang J, Wang J, Zhong W, et al. Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth. J Cancer Res Clin Oncol. 2018;144:821-833 pubmed publisher
    ..Expression of Gln transporter ASCT2 and glutamine synthetase (GS) in the parental and molecularly engineered GC cells or in human GC specimens was ..
  52. Passera A, Marcolungo L, Casati P, Brasca M, Quaglino F, Cantaloni C, et al. Hybrid genome assembly and annotation of Paenibacillus pasadenensis strain R16 reveals insights on endophytic life style and antifungal activity. PLoS ONE. 2018;13:e0189993 pubmed publisher
    ..In this study, we have characterized the genome of Paenibacillus pasadenensis, strain R16, recently investigated for its antifungal activities and plant-associated features...
  53. Ono M, Oka S, Okudaira H, Nakanishi T, Mizokami A, Kobayashi M, et al. [(14)C]Fluciclovine (alias anti-[(14)C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells. Nucl Med Biol. 2015;42:887-92 pubmed publisher
    ..Our previous study showed that ASCT2 (Na(+)-dependent amino acid transporter (AAT)) mediates fluciclovine uptake in androgen-dependent PCa cells; its ..
  54. Lee N, Kim Y, Ryu H, Kang Y. The alteration of serine transporter activity in a cell line model of amyotrophic lateral sclerosis (ALS). Biochem Biophys Res Commun. 2017;483:135-141 pubmed publisher
    ..As a result of small interfering RNA experiments, we found that ASCT2 (SLC1A5) and ASCT1 (SLC1A4) are involved in [3H]d-serine and [3H]l-serine uptake in NSC-34/hSOD1..
  55. Yamada N, Honda Y, Takemoto H, Nomoto T, Matsui M, Tomoda K, et al. Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism. Sci Rep. 2017;7:6077 pubmed publisher
    ..polymer to achieve a selective high affinity to tumour cells overexpressing glutaminolysis-related transporter ASCT2. In in vitro study, our developed polymer exhibited faster and higher cellular uptake in tumour cells than that in ..
  56. Wich C, Kausler S, Dotsch J, Rascher W, Knerr I. Syncytin-1 and glial cells missing a: hypoxia-induced deregulated gene expression along with disordered cell fusion in primary term human trophoblasts. Gynecol Obstet Invest. 2009;68:9-18 pubmed publisher
    ..levels of hypoxia alter the expression of syncytin-1, glial cells missing a (GCMa) and syncytin-1 receptor ASCT2 and affect syncytialization in primary term human trophoblasts...
  57. Kekuda R, Prasad P, Fei Y, Torres Zamorano V, Sinha S, Yang Feng T, et al. Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. J Biol Chem. 1996;271:18657-61 pubmed
    ..Chromosomal assignment studies with somatic cell hybrid analysis and fluorescent in situ hybridization have located the ATBo gene to human chromosome 19q13.3.
  58. Morgun A, Kuvacheva N, Khilazheva E, Taranushenko T, Salmina A. Expression of Glutamate and Glutamine Transporter Proteins in Neurovascular Unit Cells In Vitro. Bull Exp Biol Med. 2015;159:614-6 pubmed publisher
    Glutamine transporter protein SLC1A5 and glutamate transporter protein EAAT2 responsible for cell-cell communication and energetic coupling were studied using in vitro model of multicellular neurovascular unit consisting of astrocytes, ..
  59. Soygur B, Sati L, Demir R. Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta. Histol Histopathol. 2016;31:1037-47 pubmed publisher
    Syncytins belong to the Human Endogenous Retrovirus family. The syncytin-1 receptor, SLC1A5, and syncytin-2 receptor, MFSD2, interact with their respective syncytin proteins to induce syncytiotrophoblast formation...
  60. Timosenko E, Ghadbane H, Silk J, Shepherd D, Gileadi U, Howson L, et al. Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells. Cancer Res. 2016;76:6193-6204 pubmed
    ..2,3-dioxygenase (TDO) resulted in ATF4-dependent upregulation of several amino acid transporters, including SLC1A5 and its truncated isoforms, which in turn enhanced tryptophan and glutamine uptake...
  61. Sanchez E, Carroll P, Thalhofer A, Lagunoff M. Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival. PLoS Pathog. 2015;11:e1005052 pubmed publisher
    ..KSHV infection of endothelial cells induces protein expression of the glutamine transporter, SLC1A5. Chemical inhibition of SLC1A5, or knockdown by siRNA, leads to similar cell death rates as glutamine deprivation ..
  62. Irving B, Wood G, Bennotti P, Babu E, Deshpande A, Lent M, et al. Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery. Nutrients. 2016;8: pubmed
    ..625, p < 0.0001), asct2 (r = -0.320, p = 0.039), lat1 (r = -0.304, p = 0.05)...
  63. Chiu M, Sabino C, Taurino G, Bianchi M, Andreoli R, Giuliani N, et al. GPNA inhibits the sodium-independent transport system L for neutral amino acids. Amino Acids. 2017;49:1365-1372 pubmed publisher
    L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine transporter ASCT2, although it is known that it also inhibits other sodium-dependent amino acid transporters...
  64. Suzuki M, Toki H, Furuya A, Ando H. Establishment of monoclonal antibodies against cell surface domains of ASCT2/SLC1A5 and their inhibition of glutamine-dependent tumor cell growth. Biochem Biophys Res Commun. 2017;482:651-657 pubmed publisher
    Human alanine-serine-cysteine transporter 2 (ASCT2; SLC1A5) is a major transporter of the amino acid glutamine that is known to be overexpressed in certain malignant tumors...
  65. Bröer A, Rahimi F, Broer S. Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. J Biol Chem. 2016;291:13194-205 pubmed publisher
    ..transporters are essential for cancer growth and are potential targets for cancer chemotherapy with ASCT2 (SLC1A5) being investigated most intensively...
  66. Kudryavtseva A, Osetrova M, Livinyuk V, Manukhov I, Zavilgelsky G. [The importance of C-terminal aspartic acid residue (D141) to the antirestriction activity of the ArdB (R64) protein]. Mol Biol (Mosk). 2017;51:831-835 pubmed publisher
    ..of the amino acid sequences of ArdB homologues demonstrated the presence of four groups of conserved residues ((1) R16, E32, and W51; (2) Y46 and G48; (3) S81, D83 and E132, and (4) N77, L(I)140, and D141) on the surface of the ..
  67. Kim S, Kim D, Jung W, Koo J. Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. Endocr Relat Cancer. 2013;20:339-48 pubmed publisher
    ..including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular ..
  68. Kaira K, Sunose Y, Arakawa K, Sunaga N, Shimizu K, Tominaga H, et al. Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma. Histopathology. 2015;66:234-43 pubmed publisher
    ASC amino acid transporter-2 (ASCT2) is highly expressed in cancer cells. However, the clinicopathological significance of ASCT2 expression in pancreatic cancer remains unclear...
  69. Console L, Scalise M, Tarmakova Z, Coe I, Indiveri C. N-linked glycosylation of human SLC1A5 (ASCT2) transporter is critical for trafficking to membrane. Biochim Biophys Acta. 2015;1853:1636-45 pubmed publisher
    The human amino acid transporter SLC1A5 (ASCT2) contains two N-glycosylation sites (N163 and N212) located in the large extracellular loop. In the homology structural model of ASCT2 these Asn residues are extracellularly exposed...
  70. Malicorne S, Vernochet C, Cornelis G, Mulot B, Delsuc F, Heidmann O, et al. Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor. J Virol. 2016;90:8132-49 pubmed publisher
    ..The sodium-dependent neutral amino acid transporter ASCT2 is the common receptor of the large RD114 retrovirus interference group, whose members display frequent env ..
  71. Lou D, Wang Y, Tan J, Zhu L, Ji S, Wang B. Functional contribution of coenzyme specificity-determining sites of 7α-hydroxysteroid dehydrogenase from Clostridium absonum. Comput Biol Chem. 2017;70:89-95 pubmed publisher
    ..short-chain dehydrogenase/reductase superfamily (SDRs), possesses positively charged CSDSs that mainly contain T15, R16, R38, and R194, forming complicated polar interactions with the adenosine ribose C2 phosphate group of NADP(H)...
  72. Glyakina A, Likhachev I, Balabaev N, Galzitskaya O. Comparative mechanical unfolding studies of spectrin domains R15, R16 and R17. J Struct Biol. 2018;201:162-170 pubmed publisher
    ..we have studied the structural and mechanical properties of three repeats of chicken brain α-spectrin (R15, R16 and R17) at the atomic level under stretching at constant velocities (0.01, 0.05 and 0...
  73. Bröer A, Wagner C, Lang F, Broer S. Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance. Biochem J. 2000;346 Pt 3:705-10 pubmed
    The neutral amino acid transporter ASCT2 mediates electroneutral obligatory antiport but at the same time requires Na(+) for its function...
  74. Huang F, Zhao Y, Zhao J, Wu S, Jiang Y, Ma H, et al. Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer. Int J Clin Exp Pathol. 2014;7:6006-14 pubmed
    ..b>SLC1A5 is an important transporter of glutamine various cancer cells...
  75. Jeon Y, Khelifa S, Ratnikov B, Scott D, Feng Y, Parisi F, et al. Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. Cancer Cell. 2015;27:354-69 pubmed publisher
    ..We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the ubiquitin ligase RNF5...
  76. Singh K, Tanui R, Gameiro A, Eisenberg G, Colas C, Schlessinger A, et al. Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2. Bioorg Med Chem Lett. 2017;27:398-402 pubmed publisher
    The glutamine transporter ASCT2 has been identified as a promising target to inhibit rapid growth of cancer cells. However, ASCT2 pharmacology is not well established...
  77. Bjersand K, Seidal T, Sundström Poromaa I, Akerud H, Skirnisdottir I. The clinical and prognostic correlation of HRNPM and SLC1A5 in pathogenesis and prognosis in epithelial ovarian cancer. PLoS ONE. 2017;12:e0179363 pubmed publisher
    ..the prognostic effect of the Heterogeneous nuclear ribonucleoprotein type M (HNRPM) and Solute carrier 1A5 (SLC1A5) in FIGO-stages I-II epithelial ovarian cancer...
  78. Lu J, Chen M, Tao Z, Gao S, Li Y, Cao Y, et al. Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo. Oncotarget. 2017;8:76458-76467 pubmed publisher
    To investigate the oncogenic effects of SLC1A5 on gastric cancer development in vitro and in vivo.
  79. Barel M, Meibom K, Dubail I, Botella J, Charbit A. Francisella tularensis regulates the expression of the amino acid transporter SLC1A5 in infected THP-1 human monocytes. Cell Microbiol. 2012;14:1769-83 pubmed publisher
    ..b>SLC1A5 is a neutral amino acid transporter expressed by human cells, which serves, along with SLC7A5 to equilibrate ..
  80. Tailor C, Marin M, Nouri A, Kavanaugh M, Kabat D. Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. J Biol Chem. 2001;276:27221-30 pubmed
    The sodium-dependent neutral amino acid transporter type 2 (ASCT2) was recently identified as a cell surface receptor for endogenously inherited retroviruses of cats, baboons, and humans as well as for horizontally transmitted type-D ..
  81. Larriba S, Sumoy L, Ramos M, Gimenez J, Estivill X, Casals T, et al. ATB(0)/SLC1A5 gene. Fine localisation and exclusion of association with the intestinal phenotype of cystic fibrosis. Eur J Hum Genet. 2001;9:860-6 pubmed
  82. Knerr I, Weigel C, Linnemann K, Dotsch J, Meissner U, Fusch C, et al. Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons. Am J Obstet Gynecol. 2003;189:583-8 pubmed
    ..play a role in altered placentogenesis; we investigated the influence of hypoxia on syncytin and its receptor ASCT2 gene expression in BeWo cells and in ex vivo perfused human cotyledons...
  83. Renga B, Mencarelli A, Cipriani S, D Amore C, Zampella A, Monti M, et al. The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate. Biochim Biophys Acta. 2011;1812:1522-31 pubmed publisher
    ..In conclusion, FXR activation regulates glutamine and glutamate metabolism and FXR ligands might have utility in the treatment of hyperammonemia states. ..
  84. van Geldermalsen M, Wang Q, Nagarajah R, Marshall A, Thoeng A, Gao D, et al. ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene. 2016;35:3201-8 pubmed publisher
    Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells...
  85. Roy A, Sharma N, Chakraborty A, Upadhyay A. Measurement of atmospheric carbon dioxide and water vapor in built-up urban areas in the Gandhinagar-Ahmedabad region in India using a portable tunable diode laser spectroscopy system. Appl Opt. 2017;56:H57-H66 pubmed publisher
    ..67 ppm. A 1 mW, 2004-nm vertical cavity surface-emitting laser is used to selectively interrogate the R16 transition of carbon dioxide at 2003.5 nm (4991.2585 cm-1)...
  86. Sugimoto J, Sugimoto M, BERNSTEIN H, Jinno Y, Schust D. A novel human endogenous retroviral protein inhibits cell-cell fusion. Sci Rep. 2013;3:1462 pubmed publisher
    ..cell-cell fusion in trophoblast cells and cell-associated and secreted suppressyn binds to the syn1 receptor, ASCT2. Identification of the first host cell-encoded inhibitor of mammalian cell fusion may encourage improved ..
  87. Wang Q, Hardie R, Hoy A, van Geldermalsen M, Gao D, Fazli L, et al. Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development. J Pathol. 2015;236:278-89 pubmed publisher
    ..In this study, we demonstrated that the glutamine transporter ASCT2 (SLC1A5) is highly expressed in prostate cancer patient samples...
  88. Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, et al. Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma. Pathol Oncol Res. 2015;21:1175-81 pubmed publisher
    ..Tumor sections were stained by immunohistochemistry for LAT1, 4F2hc, system ASC amino acid transporter-2 (ASCT2), cell proliferation by Ki-67, microvessel density (MVD) determined by CD34 and p53...
  89. Bernhardt S, Bayerlová M, Vetter M, Wachter A, Mitra D, Hanf V, et al. Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors. Breast Cancer Res. 2017;19:112 pubmed publisher
    ..demonstrated the central role of serine hydroxymethyltransferase 2 (SHMT2) and amino acid transporter ASCT2 (SLC1A5) as independent prognostic factors in breast cancer patients...
  90. Brauers E, Vester U, Zerres K, Eggermann T. Search for mutations in SLC1A5 (19q13) in cystinuria patients. J Inherit Metab Dis. 2005;28:1169-71 pubmed
    To elucidate whether SLC1A5 is involved in the aetiology of cystinuria, we screened two non-type I cystinuria families without detectable mutations inSLC7A9 (and SLC3A1) but compatible with linkage to 19q13 for genomic variants in SLC1A5...
  91. Lu H, Li X, Lu Y, Qiu S, Fan Z. ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer Lett. 2016;381:23-30 pubmed publisher
    Therapeutic targeting of ASCT2, a glutamine transporter that plays a major role in glutamine uptake in cancer cells, is challenging because ASCT2 also has a biological role in normal tissues...
  92. Tao X, Lu Y, Qiu S, Wang Y, Qin J, Fan Z. AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis. Cancer Lett. 2017;408:33-42 pubmed publisher
    In this study, we expanded our recent work showing that ASCT2, a Na+-dependent neutral amino acid transporter that plays a major role in glutamine uptake in cancer cells, is physically associated with EGFR in human head and ..